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hydrocortisone cypionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 1390 | 508-99-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.23 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK | 16 | |||
| kinase-selectivity-class | EIF2AK3,GRK2 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 2.037 | Moderate | 0.67 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| rat-kpuu-brain | Rat brain Kpuu | 0.048 | % | Moderate | 0.67 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 10, 1955 | FDA | PHARMACIA AND UPJOHN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
| CHEBI has role | CHEBI:49167 | anti-asthmatic drugs |
| CHEBI has role | CHEBI:50857 | anti-allergic drugs |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:88188 | allergenic drug |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.94 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017944 | VUID |
| N0000179568 | NUI |
| D00976 | KEGG_DRUG |
| 4017941 | VANDF |
| 4017944 | VANDF |
| C0612688 | UMLSCUI |
| CHEBI:5783 | CHEBI |
| CHEMBL1549 | ChEMBL_ID |
| DB14541 | DRUGBANK_ID |
| C029109 | MESH_SUPPLEMENTAL_RECORD_UI |
| 4XDY25L70B | UNII |
| 223253 | PUBCHEM_CID |
| DB00741 | DRUGBANK_ID |
| 163524 | RXNORM |
| 2500 | MMSL |
| 4837 | MMSL |
| 4841 | MMSL |
| d00254 | MMSL |
| 002147 | NDDF |
| 002150 | NDDF |
| 109063008 | SNOMEDCT_US |
| 16602005 | SNOMEDCT_US |
| 396458002 | SNOMEDCT_US |
| 56423005 | SNOMEDCT_US |
| C0020268 | UMLSCUI |
| 5754 | PUBCHEM_CID |
| 38 | INN_ID |
| D006854 | MESH_DESCRIPTOR_UI |
| CHEBI:17650 | CHEBI |
| 4XDY25L70B | INXIGHT DRUGS |
Pharmaceutical products:
None