hydrocortamate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 1387 76-47-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydrocortamate
  • ethamicort
  • magnacort
  • hydrocortamate hydrochloride
  • hydrocortamate HCl
  • Molecular weight: 475.63
  • Formula: C27H41NO6
  • CLOGP: 3.50
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 104.14
  • ALOGS: -3.75
  • ROTB: 8

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.23 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

DateAgencyCompanyOrphan
Oct. 15, 1956 FDA PFIZER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:49167 anti-asthmatic drugs
CHEBI has role CHEBI:50857 anti-allergic drugs
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:88188 allergenic drug
CHEBI has role CHEBI:35705 immunosuppressive agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.94 acidic
pKa2 8.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
125-03-1 SECONDARY_CAS_RN
4017941 VANDF
C0544368 UMLSCUI
CHEBI:50851 CHEBI
CHEBI:17650 CHEBI
CHEMBL1201263 ChEMBL_ID
DB00769 DRUGBANK_ID
686 INN_ID
Y3N00BK5WK UNII
84088 PUBCHEM_CID
DB00741 DRUGBANK_ID
5492 RXNORM
2500 MMSL
4837 MMSL
d00254 MMSL
002147 NDDF
002187 NDDF
004860 NDDF
116600001 SNOMEDCT_US
16602005 SNOMEDCT_US
35531004 SNOMEDCT_US
396458002 SNOMEDCT_US
412205004 SNOMEDCT_US
C0020268 UMLSCUI
CHEMBL1200635 ChEMBL_ID
38 INN_ID
5754 PUBCHEM_CID
D006854 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None