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hydrocortamate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| corticosteroids, except prednisolone derivatives | 1387 | 76-47-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.23 mg/mL | Bocci G, Oprea TI, Benet LZ |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,NTRK2,PDK1,PDK2,PRKDC,TEK | 14 | |||
| kinase-selectivity-class | EIF2AK3,GRK2 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 9.727 | Moderate | 0.68 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| rat-kpuu-brain | Rat brain Kpuu | 0.016 | % | Moderate | 0.68 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 15, 1956 | FDA | PFIZER |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drug |
| CHEBI has role | CHEBI:35705 | immunosuppressive agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.94 | acidic |
| pKa2 | 8.0 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017941 | VANDF |
| C0544368 | UMLSCUI |
| CHEBI:50851 | CHEBI |
| CHEMBL1201263 | ChEMBL_ID |
| CHEMBL1200635 | ChEMBL_ID |
| DB00769 | DRUGBANK_ID |
| 686 | INN_ID |
| 125-03-1 | SECONDARY_CAS_RN |
| Y3N00BK5WK | UNII |
| 84088 | PUBCHEM_CID |
| DB00741 | DRUGBANK_ID |
| 5492 | RXNORM |
| 2500 | MMSL |
| 4837 | MMSL |
| d00254 | MMSL |
| 002147 | NDDF |
| 002187 | NDDF |
| 004860 | NDDF |
| 116600001 | SNOMEDCT_US |
| 16602005 | SNOMEDCT_US |
| 35531004 | SNOMEDCT_US |
| 396458002 | SNOMEDCT_US |
| 412205004 | SNOMEDCT_US |
| 56423005 | SNOMEDCT_US |
| C0020268 | UMLSCUI |
| 5754 | PUBCHEM_CID |
| 38 | INN_ID |
| D006854 | MESH_DESCRIPTOR_UI |
| CHEBI:17650 | CHEBI |
| Y3N00BK5WK | INXIGHT DRUGS |
Pharmaceutical products:
None