hexylcaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	1373	532-77-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hexylcaine
osmocaine
cyclain
hexylcaine hydrochloride
hexylcaine HCl

Molecular weight: 261.37
Formula: C16H23NO2
CLOGP: 3.94
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 38.33
ALOGS: -4.43
ROTB: 6

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA	MERCK

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Local anesthesia	indication	386761002
Conduction disorder of the heart	contraindication	44808001
Decreased respiratory function	contraindication	80954004
Open wound	contraindication	125643001
Seizure disorder	contraindication	128613002
Denuded skin	contraindication	418242004

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.06	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN	BLOCKER	IC50	5.15		CHEMBL	CHEMBL

External reference:

ID	Source
532-76-3	SECONDARY_CAS_RN
C0062686	UMLSCUI
CHEBI:34791	CHEBI
CHEMBL1197	ChEMBL_ID
D02454	KEGG_DRUG
DB00473	DRUGBANK_ID
C004954	MESH_SUPPLEMENTAL_RECORD_UI
10770	PUBCHEM_CID
7196	IUPHAR_LIGAND_ID
274	INN_ID
511IU0826Z	UNII
1546032	RXNORM
001354	NDDF
004568	NDDF
16392005	SNOMEDCT_US
CHEMBL1200715	ChEMBL_ID

Pharmaceutical products:

None