hexestrol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
estrogens	1368	84-16-2

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

dihydrodiethylstilbestrol
hexestrol
cycloestrol
erythrohexestrol
hexanoestrol
hexestrofen
hexoestrol
hormoestrol
mesohexestrol

A synthetic estrogen that has been used as a hormonal antineoplastic agent.

Molecular weight: 270.37
Formula: C18H22O2
CLOGP: 5.11
LIPINSKI: 1
HAC: 2
HDO: 2
TPSA: 40.46
ALOGS: -4.29
ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018931	Antineoplastic Agents, Hormonal
MeSH PA	D004967	Estrogens
MeSH PA	D004968	Estrogens, Non-Steroidal
MeSH PA	D006728	Hormones

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.8	acidic
pKa2	11.4	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN	ANTAGONIST	Ki	10.30		IUPHAR

External reference:

ID	Source
D01641	KEGG_DRUG
C0019467	UMLSCUI
CHEBI:31669	CHEBI
HXS	PDB_CHEM_ID
CHEMBL6615	ChEMBL_ID
CHEMBL9225	ChEMBL_ID
DB07931	DRUGBANK_ID
D006589	MESH_DESCRIPTOR_UI
3606	PUBCHEM_CID
2823	IUPHAR_LIGAND_ID
2074	INN_ID
10BI795R7D	UNII
001282	NDDF
126069000	SNOMEDCT_US
26303005	SNOMEDCT_US

Pharmaceutical products:

None