guanadrel 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antihypertensives, guanidine derivatives | 1339 | 40580-59-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 18.48 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 85 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 29, 1982 | FDA | PHARMACIA AND UPJOHN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| CHEBI has role | CHEBI:37887 | adrenergic blockers |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Hypertensive disorder | indication | 38341003 | DOID:10763 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.82 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Transporter | SUBSTRATE | DRUGBANK | CHEMBL | |||||
| Alpha-1A adrenergic receptor | GPCR | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| 4019769 | VUID |
| N0000179147 | NUI |
| D00607 | KEGG_DRUG |
| 22195-34-2 | SECONDARY_CAS_RN |
| 4018079 | VANDF |
| 4019769 | VANDF |
| C0061938 | UMLSCUI |
| CHEBI:5555 | CHEBI |
| CHEMBL1037 | ChEMBL_ID |
| DB00226 | DRUGBANK_ID |
| CHEMBL3184143 | ChEMBL_ID |
| 38521 | PUBCHEM_CID |
| C004945 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7193 | IUPHAR_LIGAND_ID |
| 2590 | INN_ID |
| 765C9332T4 | UNII |
| 217653 | RXNORM |
| 1821 | MMSL |
| 4807 | MMSL |
| d00725 | MMSL |
| 000641 | NDDF |
| 004494 | NDDF |
| 14013006 | SNOMEDCT_US |
| 372820001 | SNOMEDCT_US |
| 69204002 | SNOMEDCT_US |
Pharmaceutical products:
None