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gestrinone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids, progestogens | 1292 | 16320-04-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A non-estrogenic contraceptive which is a weak progestin with strong anti-progesterone properties. It is effective if used once a week orally or can also be used in intravaginal devices.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.70 | mg | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 | 37 | |||
| kinase-selectivity-class | GRK2,MAP2K6,MAP3K14,STK33 | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | G03XA02 | GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM OTHER SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM Antigonadotropins and similar agents |
| MeSH PA | D000080066 | Contraceptive Agents, Hormonal |
| MeSH PA | D003271 | Contraceptive Agents, Female |
| MeSH PA | D003278 | Contraceptives, Oral, Hormonal |
| MeSH PA | D006728 | Hormones |
| MeSH PA | D011372 | Progestins |
| MeSH PA | D012102 | Reproductive Control Agents |
Related Drugs by ATC class:
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.35 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sex hormone-binding globulin | Secreted | Kd | 8.11 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000167403 | NUI |
| D04317 | KEGG_DRUG |
| C0017507 | UMLSCUI |
| CHEBI:89642 | CHEBI |
| CHEMBL1868702 | ChEMBL_ID |
| DB11619 | DRUGBANK_ID |
| D005867 | MESH_DESCRIPTOR_UI |
| 27812 | PUBCHEM_CID |
| 4285 | INN_ID |
| 1421533RCM | UNII |
| 4792 | RXNORM |
| 003973 | NDDF |
| 387589005 | SNOMEDCT_US |
| 96380003 | SNOMEDCT_US |
| 1421533RCM | INXIGHT DRUGS |
Pharmaceutical products:
None