etoposide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1112 33419-42-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • etoposide
  • etosid
  • fytosid
  • toposar
  • zuyeyidal
  • VP-16
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
  • Molecular weight: 588.56
  • Formula: C29H32O13
  • CLOGP: 0.59
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 3
  • TPSA: 160.83
  • ALOGS: -2.78
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.11 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 38 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.30 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 52 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 10, 1983 FDA
March 26, 2019 PMDA BRISTOL-MYERS SQUIBB K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3122.49 17.28 1717 57632 116732 63312941
Neutropenia 1309.99 17.28 1173 58176 173832 63255841
Mucosal inflammation 1103.46 17.28 633 58716 46295 63383378
Pancytopenia 935.79 17.28 753 58596 96180 63333493
Disease progression 843.04 17.28 785 58564 121973 63307700
Bone marrow failure 819.04 17.28 443 58906 28847 63400826
Thrombocytopenia 804.55 17.28 841 58508 150316 63279357
Acute myeloid leukaemia 660.87 17.28 322 59027 16825 63412848
Haematotoxicity 556.98 17.28 238 59111 9138 63420535
Product use in unapproved indication 548.06 17.28 752 58597 178328 63251345
Off label use 545.74 17.28 1618 57731 672844 62756829
Myelodysplastic syndrome 540.77 17.28 279 59070 16475 63413198
Myelosuppression 420.25 17.28 267 59082 23436 63406237
Ovarian failure 404.16 17.28 114 59235 1196 63428477
Sepsis 394.73 17.28 593 58756 152530 63277143
Haemophagocytic lymphohistiocytosis 360.36 17.28 183 59166 10444 63419229
Neutropenic sepsis 349.60 17.28 208 59141 16230 63413443
Second primary malignancy 344.84 17.28 162 59187 7791 63421882
Pain 340.92 17.28 134 59215 740494 62689179
Venoocclusive liver disease 335.05 17.28 137 59212 4698 63424975
Febrile bone marrow aplasia 329.33 17.28 153 59196 7172 63422501
Malignant neoplasm progression 318.24 17.28 388 58961 81733 63347940
Septic shock 311.98 17.28 347 59002 66282 63363391
Multiple organ dysfunction syndrome 301.53 17.28 316 59033 56436 63373237
Neutrophil count decreased 285.35 17.28 306 59043 56100 63373573
Tumour lysis syndrome 285.11 17.28 148 59201 8842 63420831
Arthralgia 280.66 17.28 92 59257 569618 62860055
Joint swelling 277.47 17.28 6 59343 327660 63102013
Anaemia 253.74 17.28 723 58626 292707 63136966
Posterior reversible encephalopathy syndrome 243.55 17.28 169 59180 17176 63412497
Aplasia 239.40 17.28 104 59245 4155 63425518
Diffuse large B-cell lymphoma recurrent 225.39 17.28 84 59265 2236 63427437
Renal salt-wasting syndrome 223.33 17.28 54 59295 288 63429385
Diffuse large B-cell lymphoma refractory 222.93 17.28 71 59278 1159 63428514
Abdominal discomfort 215.99 17.28 24 59325 320861 63108812
Nasopharyngitis 206.45 17.28 7 59342 254250 63175423
Disease recurrence 204.96 17.28 186 59163 27844 63401829
Pyrexia 200.03 17.28 919 58430 469559 62960114
Encephalopathy 199.66 17.28 212 59137 38408 63391265
Platelet count decreased 197.80 17.28 374 58975 115748 63313925
Cytopenia 186.66 17.28 123 59226 11478 63418195
Contraindicated product administered 184.08 17.28 4 59345 217644 63212029
Systemic lupus erythematosus 180.08 17.28 3 59346 208915 63220758
Arthropathy 175.92 17.28 11 59338 234781 63194892
Drug resistance 175.21 17.28 156 59193 22777 63406896
Leukopenia 174.64 17.28 282 59067 77008 63352665
Drug hypersensitivity 173.66 17.28 39 59310 310648 63119025
Product dose omission issue 169.68 17.28 13 59336 234300 63195373
Hepatitis B reactivation 167.86 17.28 74 59275 3063 63426610
Ototoxicity 164.80 17.28 58 59291 1304 63428369
Cardiotoxicity 161.95 17.28 100 59249 8338 63421335
Stem cell transplant 159.01 17.28 61 59288 1761 63427912
Maternal exposure before pregnancy 158.49 17.28 95 59254 7508 63422165
Peripheral swelling 157.70 17.28 29 59320 265913 63163760
Neoplasm progression 155.61 17.28 181 59168 36247 63393426
Pruritus 150.58 17.28 75 59274 361378 63068295
Fall 149.56 17.28 91 59258 392243 63037430
Swelling 147.13 17.28 38 59311 275340 63154333
Bacteraemia 146.60 17.28 125 59224 17223 63412450
Neutropenic colitis 146.46 17.28 67 59282 3028 63426645
Headache 145.63 17.28 230 59119 633011 62796662
Cytomegalovirus infection 145.31 17.28 135 59214 20817 63408856
Venoocclusive disease 144.92 17.28 59 59290 1999 63427674
Rash 143.41 17.28 189 59160 560682 62868991
Musculoskeletal stiffness 143.38 17.28 7 59342 184611 63245062
Glossodynia 141.47 17.28 6 59343 178870 63250803
Aspergillus infection 138.01 17.28 89 59260 8004 63421669
Malignant transformation 136.43 17.28 38 59311 379 63429294
Weight increased 133.66 17.28 39 59310 260753 63168920
Drug intolerance 131.63 17.28 62 59287 308599 63121074
Therapy partial responder 131.51 17.28 96 59253 10562 63419111
Teratoma 129.95 17.28 30 59319 126 63429547
Malaise 127.19 17.28 121 59228 415833 63013840
Candida infection 122.98 17.28 142 59207 28209 63401464
Therapeutic product effect decreased 121.31 17.28 18 59331 193169 63236504
Ovarian germ cell teratoma 121.01 17.28 25 59324 53 63429620
Hypersensitivity 119.94 17.28 62 59287 292623 63137050
Hepatosplenic T-cell lymphoma 118.39 17.28 37 59312 566 63429107
Fatigue 116.65 17.28 433 58916 887595 62542078
Insomnia 114.37 17.28 30 59319 215222 63214451
Pulmonary haemorrhage 112.76 17.28 75 59274 7106 63422567
Human herpesvirus 6 infection 112.27 17.28 55 59294 2902 63426771
Bronchopulmonary aspergillosis 111.61 17.28 80 59269 8555 63421118
Thrombotic microangiopathy 110.08 17.28 86 59263 10475 63419198
Discomfort 108.84 17.28 14 59335 167360 63262313
Colitis 108.12 17.28 176 59173 48352 63381321
Oesophagitis 106.58 17.28 98 59251 14910 63414763
Acute graft versus host disease 104.60 17.28 60 59289 4368 63425305
Graft versus host disease 99.89 17.28 68 59281 6695 63422978
Asthma 98.49 17.28 5 59344 127556 63302117
Urticaria 98.40 17.28 18 59331 165784 63263889
Enterococcal infection 97.53 17.28 71 59278 7777 63421896
Injection site pain 97.41 17.28 6 59343 129794 63299879
Neurotoxicity 96.28 17.28 98 59251 16892 63412781
Clostridium difficile colitis 95.96 17.28 107 59242 20462 63409211
Primary hypogonadism 95.35 17.28 24 59325 155 63429518
Dizziness 94.10 17.28 161 59188 429764 62999909
Pain in extremity 93.79 17.28 103 59246 331383 63098290
Respiratory failure 93.62 17.28 257 59092 101601 63328072
Hypokalaemia 91.55 17.28 258 59091 103546 63326127
Alveolar soft part sarcoma 91.39 17.28 21 59328 86 63429587
Premature menopause 89.44 17.28 33 59316 853 63428820
Anxiety 89.19 17.28 46 59303 217495 63212178
Aplastic anaemia 85.06 17.28 71 59278 9498 63420175
Cystitis haemorrhagic 84.59 17.28 51 59298 4072 63425601
Leukoencephalopathy 83.92 17.28 52 59297 4361 63425312
Klebsiella infection 83.37 17.28 67 59282 8499 63421174
Pericarditis 83.18 17.28 12 59337 131567 63298106
White blood cell count decreased 82.76 17.28 302 59047 138802 63290871
Muscle spasms 82.47 17.28 22 59327 156128 63273545
Osteosarcoma 80.86 17.28 20 59329 119 63429554
Feeling abnormal 78.19 17.28 21 59328 148371 63281302
Lymphopenia 78.14 17.28 91 59258 18236 63411437
Acute respiratory distress syndrome 78.06 17.28 103 59246 23431 63406242
Contusion 77.62 17.28 22 59327 150022 63279651
Enterobacter infection 74.46 17.28 38 59311 2189 63427484
Hepatic enzyme increased 74.12 17.28 49 59300 202279 63227394
Hypomagnesaemia 73.41 17.28 111 59238 28626 63401047
Disseminated intravascular coagulation 72.05 17.28 89 59260 18962 63410711
Fungaemia 71.73 17.28 38 59311 2365 63427308
Sinusitis 71.44 17.28 64 59285 226589 63203084
Teratoma benign 71.39 17.28 16 59333 57 63429616
Bronchitis 71.09 17.28 15 59334 124920 63304753
Impaired healing 70.60 17.28 7 59342 102535 63327138
Cervix disorder 70.21 17.28 25 59324 582 63429091
Skin candida 69.54 17.28 33 59316 1622 63428051
Nephropathy toxic 69.46 17.28 63 59286 9416 63420257
Psoriasis 68.44 17.28 3 59346 86954 63342719
Complications of bone marrow transplant 68.43 17.28 23 59326 448 63429225
Neuropathy peripheral 67.78 17.28 247 59102 113420 63316253
Cytomegalovirus viraemia 67.70 17.28 50 59299 5599 63424074
Human bocavirus infection 67.33 17.28 22 59327 391 63429282
Klebsiella sepsis 67.29 17.28 31 59318 1424 63428249
Blood cholesterol increased 65.85 17.28 6 59343 94026 63335647
Blister 65.38 17.28 20 59329 129794 63299879
Graft versus host disease in skin 64.99 17.28 38 59311 2867 63426806
Myeloid leukaemia 64.28 17.28 21 59328 373 63429300
Ascites 64.14 17.28 127 59222 40601 63389072
Migraine 63.99 17.28 10 59339 103336 63326337
Cytomegalovirus infection reactivation 63.70 17.28 42 59307 3921 63425752
Loss of personal independence in daily activities 63.56 17.28 8 59341 97282 63332391
Capillary leak syndrome 63.45 17.28 34 59315 2166 63427507
Acute promyelocytic leukaemia 63.31 17.28 26 59323 901 63428772
Gene mutation 63.30 17.28 31 59318 1634 63428039
BK virus infection 63.27 17.28 39 59310 3240 63426433
Overdose 63.09 17.28 15 59334 115063 63314610
JC virus infection 62.83 17.28 33 59316 2018 63427655
Acute lymphocytic leukaemia recurrent 62.46 17.28 34 59315 2235 63427438
Arthritis 61.83 17.28 16 59333 115905 63313768
Inappropriate schedule of product administration 60.15 17.28 12 59337 103953 63325720
Lymphoma 59.61 17.28 65 59284 12122 63417551
Post transplant lymphoproliferative disorder 59.10 17.28 44 59305 4987 63424686
Blood pressure increased 58.33 17.28 40 59309 162022 63267651
Epstein-Barr virus infection 58.00 17.28 53 59296 7997 63421676
Injection site erythema 56.42 17.28 6 59343 83168 63346505
Systemic candida 56.10 17.28 36 59313 3209 63426464
Superior vena cava syndrome 56.02 17.28 22 59327 677 63428996
Staphylococcal infection 54.84 17.28 120 59229 41136 63388537
Large intestinal ulcer perforation 54.63 17.28 13 59336 64 63429609
Renal tubular disorder 54.57 17.28 33 59316 2649 63427024
Cytokine release syndrome 54.33 17.28 67 59282 14247 63415426
Secondary immunodeficiency 53.33 17.28 26 59323 1357 63428316
Hospitalisation 53.20 17.28 8 59341 85073 63344600
Pulmonary alveolar haemorrhage 53.00 17.28 40 59309 4628 63425045
Progressive multifocal leukoencephalopathy 52.96 17.28 63 59286 12908 63416765
Herpes simplex 52.96 17.28 51 59298 8220 63421453
Mucormycosis 52.50 17.28 33 59316 2838 63426835
Peripheral sensory neuropathy 51.63 17.28 48 59301 7403 63422270
Folliculitis 50.57 17.28 4 59345 70313 63359360
Injury 50.42 17.28 5 59344 73242 63356431
Neoplasm recurrence 49.95 17.28 31 59318 2607 63427066
Staphylococcal sepsis 49.95 17.28 49 59300 8079 63421594
Pneumatosis intestinalis 49.90 17.28 30 59319 2383 63427290
Cytomegalovirus chorioretinitis 49.73 17.28 27 59322 1766 63427907
Varicella zoster virus infection 49.40 17.28 31 59318 2658 63427015
Acute myeloid leukaemia recurrent 49.40 17.28 26 59323 1597 63428076
Acute graft versus host disease in skin 49.30 17.28 34 59315 3418 63426255
Mobility decreased 49.06 17.28 26 59323 121133 63308540
Deafness 48.20 17.28 71 59278 17886 63411787
Encephalitis viral 47.81 17.28 26 59323 1706 63427967
Pleural effusion 47.71 17.28 193 59156 93017 63336656
Leukaemia 47.65 17.28 36 59313 4172 63425501
Adverse drug reaction 46.53 17.28 9 59340 79705 63349968
Suicidal ideation 46.47 17.28 3 59346 62418 63367255
Refractory anaemia with an excess of blasts 46.42 17.28 17 59332 430 63429243
Gait disturbance 46.35 17.28 62 59287 183116 63246557
Adenovirus infection 45.95 17.28 33 59316 3538 63426135
Memory impairment 45.84 17.28 20 59329 104238 63325435
Hypothyroidism 45.72 17.28 114 59235 42518 63387155
Pneumonia fungal 45.45 17.28 39 59310 5416 63424257
Stress 45.16 17.28 5 59344 67162 63362511
Staphylococcal bacteraemia 44.99 17.28 39 59310 5491 63424182
Infusion related reaction 44.93 17.28 102 59247 245419 63184254
Influenza like illness 44.87 17.28 5 59344 66819 63362854
Pneumothorax 44.67 17.28 65 59284 16196 63413477
Fungal oesophagitis 44.54 17.28 19 59330 725 63428948
Condition aggravated 44.50 17.28 209 59140 402008 63027665
Streptococcal bacteraemia 44.45 17.28 25 59324 1752 63427921
Incorrect dose administered 44.30 17.28 3 59346 59965 63369708
Diffuse large B-cell lymphoma 44.14 17.28 42 59307 6670 63423003
Acute lymphocytic leukaemia 43.71 17.28 28 59321 2488 63427185
Amenorrhoea 43.56 17.28 50 59299 9864 63419809
Respiratory distress 43.14 17.28 97 59252 33854 63395819
Palpitations 43.07 17.28 26 59323 112744 63316929
Dry mouth 42.97 17.28 10 59339 77853 63351820
Epstein-Barr virus associated lymphoproliferative disorder 42.97 17.28 25 59324 1869 63427804
Metastases to central nervous system 42.90 17.28 57 59292 13048 63416625
Cardiomyopathy acute 42.84 17.28 14 59335 249 63429424
Gastrointestinal fungal infection 42.71 17.28 15 59334 335 63429338
Abdominal pain upper 42.64 17.28 80 59269 206364 63223309
Nasal abscess 42.40 17.28 13 59336 186 63429487
Leukaemia recurrent 42.34 17.28 22 59327 1316 63428357
Weight decreased 42.23 17.28 126 59223 276672 63153001
Lower respiratory tract infection 42.09 17.28 37 59312 132270 63297403
Mesenteric abscess 41.99 17.28 11 59338 85 63429588
Blood culture positive 41.81 17.28 35 59314 4700 63424973
Musculoskeletal pain 41.69 17.28 17 59332 92260 63337413
Enterococcal sepsis 41.13 17.28 22 59327 1396 63428277
Splenomegaly 40.39 17.28 51 59298 11106 63418567
Klebsiella bacteraemia 40.34 17.28 23 59326 1655 63428018
Sweat gland tumour 40.21 17.28 11 59338 102 63429571
Clostridium colitis 40.10 17.28 24 59325 1890 63427783
Pseudomonal sepsis 39.94 17.28 26 59323 2375 63427298
Chloroma 39.84 17.28 13 59336 230 63429443
Bacterial infection 39.78 17.28 68 59281 19431 63410242
Medulloblastoma recurrent 39.67 17.28 10 59339 65 63429608
Unmasking of previously unidentified disease 39.60 17.28 19 59330 957 63428716
Oedema peripheral 39.53 17.28 73 59276 189438 63240235
Congestive cardiomyopathy 39.36 17.28 38 59311 6144 63423529
Alopecia 39.34 17.28 172 59177 337364 63092309
Recurrent cancer 39.27 17.28 24 59325 1963 63427710
Encephalitis cytomegalovirus 39.22 17.28 16 59333 545 63429128
Escherichia bacteraemia 39.13 17.28 31 59318 3852 63425821
Cutaneous calcification 39.02 17.28 11 59338 115 63429558
Rhinovirus infection 39.00 17.28 33 59316 4496 63425177
Therapy non-responder 38.71 17.28 157 59192 75744 63353929
Fanconi syndrome 38.71 17.28 21 59328 1371 63428302
Nail pigmentation 38.61 17.28 12 59337 180 63429493
Bacterial sepsis 38.60 17.28 31 59318 3927 63425746
Blood glucose increased 38.54 17.28 15 59334 83741 63345932
Abdominal compartment syndrome 38.36 17.28 16 59333 577 63429096
Clostridium bacteraemia 37.78 17.28 12 59337 194 63429479
Peripheral motor neuropathy 37.64 17.28 22 59327 1659 63428014
Pneumocystis jirovecii pneumonia 37.19 17.28 61 59288 16853 63412820
Nasal congestion 37.10 17.28 8 59341 65652 63364021
Viraemia 37.00 17.28 20 59329 1296 63428377
Sinus polyp 36.93 17.28 14 59335 391 63429282
Venous thrombosis 36.74 17.28 33 59316 4869 63424804
Gastrooesophageal reflux disease 36.60 17.28 22 59327 95617 63334056
Acquired gene mutation 36.47 17.28 18 59331 965 63428708
T-cell lymphoma 36.34 17.28 16 59333 660 63429013
Leukoerythroblastosis 36.03 17.28 12 59337 227 63429446
T-cell lymphoma refractory 35.91 17.28 9 59340 57 63429616
Gastroenteritis norovirus 35.89 17.28 23 59326 2045 63427628
Basal ganglion degeneration 35.55 17.28 14 59335 434 63429239
Injection site reaction 35.47 17.28 6 59343 58518 63371155
Cardiomyopathy 35.44 17.28 61 59288 17523 63412150
Vision blurred 35.38 17.28 21 59328 91903 63337770
Acute kidney injury 35.29 17.28 389 58960 263026 63166647
Mucocutaneous ulceration 35.27 17.28 11 59338 167 63429506
Strongyloidiasis 35.19 17.28 19 59330 1229 63428444
Listeria sepsis 35.06 17.28 16 59333 719 63428954
Pericardial effusion 35.02 17.28 83 59266 29975 63399698
Radiation oesophagitis 35.02 17.28 13 59336 342 63429331
Hepatic failure 34.77 17.28 92 59257 35564 63394109
Hypogammaglobulinaemia 34.71 17.28 38 59311 7117 63422556
Necrotising gastritis 34.65 17.28 9 59340 67 63429606
Gastrointestinal toxicity 33.94 17.28 39 59310 7702 63421971
Blood lactate dehydrogenase increased 33.91 17.28 70 59279 23046 63406627
Cardiac failure 33.89 17.28 169 59180 88973 63340700
Wheezing 33.85 17.28 24 59325 95571 63334102
Sleep disorder 33.76 17.28 17 59332 81549 63348124
Metastases to lung 33.63 17.28 50 59299 12700 63416973
Enteritis 33.42 17.28 40 59309 8246 63421427
Device related infection 33.33 17.28 70 59279 23322 63406351
Neutrophil count abnormal 33.32 17.28 25 59324 2867 63426806
Hyperhidrosis 33.29 17.28 31 59318 107805 63321868
Hepatitis B 33.29 17.28 28 59321 3784 63425889
Metastasis 33.19 17.28 32 59317 5165 63424508
Myeloproliferative neoplasm 33.00 17.28 14 59335 527 63429146
Myocardial infarction 32.91 17.28 27 59322 99866 63329807
Hair follicle tumour benign 32.57 17.28 13 59336 418 63429255
Renal impairment 32.53 17.28 166 59183 88189 63341484
Cerebellar haemangioma 32.47 17.28 9 59340 88 63429585
Epstein Barr virus positive mucocutaneous ulcer 32.11 17.28 13 59336 434 63429239
Renal failure 32.09 17.28 204 59145 117448 63312225
Bone marrow transplant 31.80 17.28 15 59334 727 63428946
Pneumonitis 31.46 17.28 88 59261 35134 63394539
Tumour hyperprogression 31.43 17.28 9 59340 100 63429573
Subdural hygroma 31.31 17.28 11 59338 246 63429427
Plasma cell leukaemia 31.29 17.28 17 59332 1113 63428560
Delayed puberty 31.27 17.28 9 59340 102 63429571
Injection site pruritus 31.26 17.28 3 59346 45113 63384560
Gastroenteritis adenovirus 31.22 17.28 11 59338 248 63429425
Tonsillar haemorrhage 31.14 17.28 11 59338 250 63429423
T-cell type acute leukaemia 31.10 17.28 8 59341 57 63429616
Mouth ulceration 31.04 17.28 84 59265 32900 63396773
Hepatosplenomegaly 31.01 17.28 23 59326 2591 63427082
Ill-defined disorder 31.01 17.28 19 59330 81736 63347937
Tissue infiltration 30.97 17.28 14 59335 615 63429058
Neck pain 30.94 17.28 13 59336 69305 63360368
Oesophageal candidiasis 30.88 17.28 32 59317 5631 63424042
Ejection fraction decreased 30.86 17.28 66 59283 22266 63407407
Back pain 30.52 17.28 135 59214 264010 63165663
Tumour necrosis 30.40 17.28 15 59334 804 63428869
Serum ferritin increased 30.28 17.28 33 59316 6149 63423524
Metastases to diaphragm 30.21 17.28 7 59342 30 63429643
Left ventricular dysfunction 30.18 17.28 46 59303 11942 63417731
Myalgia 30.05 17.28 57 59292 146472 63283201
White blood cell count abnormal 30.02 17.28 33 59316 6209 63423464
Burning sensation 29.99 17.28 7 59342 54400 63375273
Chronic graft versus host disease 29.63 17.28 24 59325 3078 63426595
Depression 29.55 17.28 90 59259 196402 63233271
Pneumococcal sepsis 29.54 17.28 14 59335 686 63428987
Liver injury 29.26 17.28 10 59339 60510 63369163
Stenotrophomonas infection 29.03 17.28 20 59329 2007 63427666
Drug abuse 28.71 17.28 16 59333 72502 63357171
Type 2 diabetes mellitus 28.47 17.28 12 59337 63856 63365817
Confusional state 28.41 17.28 119 59230 236261 63193412
Femur fracture 28.35 17.28 3 59346 41753 63387920
Exposure during pregnancy 28.13 17.28 65 59284 155482 63274191
Cerebral toxoplasmosis 27.88 17.28 15 59334 963 63428710
Urinary tract infection 27.80 17.28 140 59209 264544 63165129
Small cell lung cancer 27.78 17.28 18 59331 1631 63428042
International normalised ratio increased 27.61 17.28 5 59344 46420 63383253
Bacterial tracheitis 27.56 17.28 6 59343 18 63429655
Epiphyses premature fusion 27.08 17.28 7 59342 51 63429622
Enterocolitis 27.00 17.28 35 59314 7823 63421850
Clostridial sepsis 26.94 17.28 12 59337 509 63429164
Synovial sarcoma 26.84 17.28 7 59342 53 63429620
Alpha haemolytic streptococcal infection 26.84 17.28 16 59333 1251 63428422
Parainfluenzae virus infection 26.55 17.28 20 59329 2307 63427366
Cardiopulmonary failure 26.45 17.28 24 59325 3588 63426085
Sinoatrial block 26.39 17.28 14 59335 874 63428799
Acute myelomonocytic leukaemia 26.37 17.28 9 59340 184 63429489
Trichosporon infection 26.28 17.28 10 59339 282 63429391
Suicide attempt 26.28 17.28 12 59337 60906 63368767
Febrile infection 26.24 17.28 17 59332 1540 63428133
B-cell lymphoma recurrent 26.23 17.28 11 59338 402 63429271
Ocular vascular disorder 26.18 17.28 11 59338 404 63429269
Eosinophilic cystitis 26.08 17.28 7 59342 60 63429613
Somnolence 26.05 17.28 83 59266 178602 63251071
Metastases to lymph nodes 25.97 17.28 35 59314 8123 63421550
Thymus enlargement 25.93 17.28 8 59341 117 63429556
Unevaluable event 25.71 17.28 8 59341 51378 63378295
Agranulocytosis 25.68 17.28 66 59283 25068 63404605
Vertigo 25.52 17.28 12 59337 59875 63369798
Rash pruritic 25.45 17.28 12 59337 59787 63369886
Drug clearance increased 25.44 17.28 8 59341 125 63429548
Pseudomonas infection 25.41 17.28 41 59308 11172 63418501
Nervous system disorder 25.40 17.28 55 59294 18711 63410962
Schistocytosis 25.30 17.28 6 59343 29 63429644
Toxic encephalopathy 25.30 17.28 31 59318 6548 63423125
Vomiting 25.25 17.28 693 58656 558924 62870749
Adverse event 25.21 17.28 16 59333 67543 63362130
Acute hepatic failure 25.14 17.28 54 59295 18273 63411400
Dry eye 25.10 17.28 4 59345 40757 63388916
Metastases to bone marrow 25.05 17.28 11 59338 451 63429222
Spinal cord paralysis 24.97 17.28 6 59343 31 63429642
Hypoaesthesia 24.70 17.28 78 59271 168315 63261358
Depressed mood 24.62 17.28 4 59345 40187 63389486
Urinary tract infection bacterial 24.50 17.28 27 59322 5095 63424578
Fungal infection 24.43 17.28 83 59266 36791 63392882
Blood pressure systolic increased 24.40 17.28 7 59342 47390 63382283
Paraneoplastic neurological syndrome 24.40 17.28 5 59344 10 63429663
Wrong technique in product usage process 24.33 17.28 14 59335 62326 63367347
Retinoblastoma 24.27 17.28 7 59342 80 63429593
Uterine enlargement 24.26 17.28 15 59334 1253 63428420
Listeriosis 24.15 17.28 16 59333 1505 63428168
Hypoglycaemia 24.14 17.28 13 59336 60052 63369621
Haematochezia 23.96 17.28 10 59339 53534 63376139
Amnesia 23.90 17.28 11 59338 55574 63374099
Cytogenetic abnormality 23.82 17.28 11 59338 508 63429165
Immune-mediated enterocolitis 23.77 17.28 18 59331 2093 63427580
Retinal pigment epitheliopathy 23.65 17.28 9 59340 254 63429419
Radiation pneumonitis 23.57 17.28 16 59333 1567 63428106
Pulmonary toxicity 23.40 17.28 36 59313 9419 63420254
Loss of consciousness 23.31 17.28 47 59302 118074 63311599
Vena cava thrombosis 23.20 17.28 18 59331 2169 63427504
Metastatic lymphoma 23.15 17.28 8 59341 170 63429503
Atypical haemolytic uraemic syndrome 23.01 17.28 12 59337 723 63428950
Streptococcal sepsis 22.81 17.28 17 59332 1929 63427744
Skin toxicity 22.80 17.28 25 59324 4689 63424984
Haemodynamic instability 22.76 17.28 35 59314 9155 63420518
Toxic neuropathy 22.59 17.28 10 59339 418 63429255
Dysphagia 22.56 17.28 151 59198 88434 63341239
Fluid retention 22.45 17.28 14 59335 59672 63370001
Anaesthesia 22.43 17.28 10 59339 425 63429248
Hepatomegaly 22.35 17.28 40 59309 11849 63417824
Hypertension 22.34 17.28 161 59188 279142 63150531
Drug clearance decreased 22.10 17.28 15 59334 1469 63428204
Cytomegalovirus colitis 21.91 17.28 18 59331 2354 63427319
Genotoxicity 21.85 17.28 5 59344 20 63429653
Prescribed overdose 21.84 17.28 3 59346 34150 63395523
Mucosal erosion 21.81 17.28 15 59334 1501 63428172
Hypoxia 21.77 17.28 112 59237 59680 63369993
Paranasal sinus mucosal hypertrophy 21.66 17.28 5 59344 21 63429652
Follicular thyroid cancer 21.62 17.28 6 59343 59 63429614
Haemoglobinaemia 21.53 17.28 6 59343 60 63429613
Cytokine storm 21.51 17.28 9 59340 327 63429346
Vulvovaginitis 21.49 17.28 9 59340 328 63429345
Respiratory tract infection fungal 21.41 17.28 10 59339 474 63429199
Cerebral salt-wasting syndrome 21.18 17.28 6 59343 64 63429609
Myelopathy 21.13 17.28 19 59330 2807 63426866
Viral haemorrhagic cystitis 21.13 17.28 12 59337 857 63428816
Primary mediastinal large B-cell lymphoma recurrent 21.09 17.28 6 59343 65 63429608
Hyperadrenocorticism 21.08 17.28 9 59340 344 63429329
Surgery 21.07 17.28 4 59345 35908 63393765
Engraftment syndrome 20.95 17.28 10 59339 498 63429175
Plasma cell myeloma refractory 20.94 17.28 9 59340 350 63429323
Ganglioneuroma 20.89 17.28 7 59342 135 63429538
Osteoporosis 20.82 17.28 14 59335 57324 63372349
Neutropenic infection 20.79 17.28 14 59335 1353 63428320
Graft versus host disease in gastrointestinal tract 20.78 17.28 20 59329 3221 63426452
Lymphadenopathy 20.77 17.28 81 59268 38377 63391296
Odynophagia 20.67 17.28 30 59319 7456 63422217
Respiratory syncytial virus infection 20.67 17.28 29 59320 6989 63422684
Neurological decompensation 20.25 17.28 18 59331 2620 63427053
Respiratory symptom 20.23 17.28 20 59329 3327 63426346
Hypovolaemic shock 20.21 17.28 27 59322 6214 63423459
Blood stem cell transplant failure 20.16 17.28 7 59342 151 63429522
Listeria encephalitis 20.08 17.28 8 59341 256 63429417
Rhinorrhoea 20.06 17.28 19 59330 65558 63364115
VIth nerve paresis 20.03 17.28 6 59343 79 63429594
Polyneuropathy 20.03 17.28 43 59306 14546 63415127
Pulmonary vascular disorder 19.94 17.28 9 59340 394 63429279
Appendicitis 19.90 17.28 31 59318 8198 63421475
Iris atrophy 19.89 17.28 6 59343 81 63429592
Peritoneal gliomatosis 19.87 17.28 4 59345 7 63429666
Metastases to spleen 19.82 17.28 7 59342 159 63429514
Oral fungal infection 19.68 17.28 19 59330 3072 63426601
Hypophosphataemia 19.66 17.28 37 59312 11389 63418284
Gastrointestinal mucosal disorder 19.58 17.28 11 59338 769 63428904
Dyspnoea 19.57 17.28 470 58879 660843 62768830
Drug ineffective for unapproved indication 19.42 17.28 73 59276 33990 63395683
Cataract 19.32 17.28 15 59334 57038 63372635
Fungal sepsis 19.30 17.28 13 59336 1257 63428416
Hot flush 19.24 17.28 12 59337 51147 63378526
Rhabdomyosarcoma recurrent 19.16 17.28 5 59344 38 63429635
Granulocytopenia 19.08 17.28 25 59324 5647 63424026
Chest pain 19.00 17.28 121 59228 215838 63213835
Hepatic lesion 18.98 17.28 23 59326 4802 63424871
Gliosis 18.91 17.28 8 59341 299 63429374
Tachycardia 18.89 17.28 181 59168 117975 63311698
Metastases to breast 18.89 17.28 8 59341 300 63429373
Vulvovaginal inflammation 18.84 17.28 11 59338 828 63428845
Retroperitoneal abscess 18.83 17.28 7 59342 185 63429488
Mesenteric haemorrhage 18.82 17.28 5 59344 41 63429632
Pneumonia pneumococcal 18.79 17.28 16 59333 2199 63427474
Skin discolouration 18.73 17.28 6 59343 37822 63391851
Choriocarcinoma 18.72 17.28 5 59344 42 63429631
Plasmacytoma 18.62 17.28 17 59332 2562 63427111
Graft versus host disease in liver 18.52 17.28 10 59339 647 63429026
Adrenocortical carcinoma 18.51 17.28 5 59344 44 63429629
Rectal fissure 18.33 17.28 10 59339 660 63429013
Paraesthesia 18.24 17.28 80 59269 156886 63272787
Dyspepsia 18.23 17.28 43 59306 102153 63327520
Lymphocyte count decreased 18.22 17.28 66 59283 30191 63399482
Limb discomfort 18.11 17.28 3 59346 29713 63399960
Embolism 18.04 17.28 29 59320 7877 63421796
Hypoglossal nerve paresis 18.04 17.28 6 59343 113 63429560
Lung infiltration 18.01 17.28 41 59308 14422 63415251
Ewing's sarcoma 17.93 17.28 3 59346 0 63429673
Transdifferentiation of neoplasm 17.90 17.28 4 59345 14 63429659
Abortion spontaneous 17.85 17.28 11 59338 47184 63382489
Electrolyte imbalance 17.77 17.28 50 59299 20026 63409647
Retinopathy 17.68 17.28 18 59331 3101 63426572
Cystitis bacterial 17.42 17.28 7 59342 229 63429444
Feeling hot 17.35 17.28 13 59336 50341 63379332
Ear infection 17.32 17.28 7 59342 38206 63391467
Acute monocytic leukaemia 17.30 17.28 6 59343 129 63429544
Intra-abdominal haemorrhage 17.29 17.28 16 59333 2453 63427220
Hypocalcaemia 17.29 17.28 67 59282 31646 63398027

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 3196.52 14.45 2598 79084 134251 34740998
Neutropenia 1015.96 14.45 1519 80163 155259 34719990
Mucosal inflammation 793.80 14.45 684 80998 37938 34837311
Disease progression 774.14 14.45 1099 80583 106978 34768271
Pancytopenia 747.81 14.45 1012 80670 94145 34781104
Myelosuppression 730.85 14.45 492 81190 18773 34856476
Bone marrow failure 689.76 14.45 561 81121 28692 34846557
Off label use 678.91 14.45 2330 79352 417194 34458055
Acute myeloid leukaemia 623.09 14.45 437 81245 17833 34857416
Thrombocytopenia 588.92 14.45 1193 80489 155054 34720195
Product use in unapproved indication 580.85 14.45 1008 80674 116491 34758758
Myelodysplastic syndrome 531.61 14.45 405 81277 18803 34856446
Haematotoxicity 440.34 14.45 261 81421 7933 34867316
Venoocclusive liver disease 369.67 14.45 231 81451 7735 34867514
Therapy partial responder 358.33 14.45 243 81439 9373 34865876
Malignant neoplasm progression 357.03 14.45 694 80988 87352 34787897
Tumour lysis syndrome 331.72 14.45 293 81389 16766 34858483
Second primary malignancy 319.65 14.45 210 81472 7676 34867573
Neutrophil count decreased 306.60 14.45 479 81203 50625 34824624
Septic shock 295.70 14.45 570 81112 71264 34803985
Sepsis 292.50 14.45 954 80728 165607 34709642
Diffuse large B-cell lymphoma recurrent 270.77 14.45 138 81544 3090 34872159
Neutropenic sepsis 270.73 14.45 238 81444 13529 34861720
Neoplasm progression 261.68 14.45 297 81385 23003 34852246
Febrile bone marrow aplasia 253.64 14.45 185 81497 8024 34867225
Fall 250.90 14.45 81 81601 202804 34672445
Renal salt-wasting syndrome 243.32 14.45 70 81612 275 34874974
Cytopenia 238.34 14.45 214 81468 12509 34862740
Product dose omission issue 215.54 14.45 17 81665 119694 34755555
Haemophagocytic lymphohistiocytosis 205.95 14.45 199 81483 12774 34862475
Leukopenia 177.13 14.45 428 81254 62428 34812821
Diffuse large B-cell lymphoma refractory 167.23 14.45 74 81608 1192 34874057
Cystitis haemorrhagic 164.23 14.45 123 81559 5556 34869693
Malignant transformation 163.67 14.45 65 81617 786 34874463
Dizziness 161.09 14.45 164 81518 218357 34656892
Arthralgia 159.91 14.45 100 81582 169941 34705308
Aplasia 159.23 14.45 111 81571 4477 34870772
Posterior reversible encephalopathy syndrome 158.58 14.45 153 81529 9801 34865448
Cardiotoxicity 155.96 14.45 119 81563 5529 34869720
Venoocclusive disease 155.77 14.45 92 81590 2775 34872474
Pyrexia 152.24 14.45 1310 80372 331703 34543546
Bacteraemia 150.25 14.45 207 81475 19510 34855739
Neutropenic colitis 147.93 14.45 92 81590 3052 34872197
Fatigue 146.28 14.45 416 81266 370237 34505012
Overdose 143.37 14.45 21 81661 91038 34784211
Fungal infection 136.28 14.45 177 81505 15758 34859491
Stomatitis 135.61 14.45 304 81378 42210 34833039
Insomnia 134.58 14.45 38 81644 103869 34771380
Anaemia 131.69 14.45 964 80718 232371 34642878
Depression 130.49 14.45 33 81649 97065 34778184
Bronchopulmonary aspergillosis 127.20 14.45 164 81518 14495 34860754
Blood pressure increased 126.27 14.45 26 81656 88076 34787173
Malaise 124.21 14.45 151 81531 185674 34689575
Aspergillus infection 123.83 14.45 148 81534 12106 34863143
Disease recurrence 121.26 14.45 196 81486 21294 34853955
Anxiety 120.44 14.45 41 81641 99387 34775862
Pain 119.99 14.45 183 81499 204492 34670757
Blood lactate dehydrogenase increased 119.40 14.45 202 81480 22788 34852461
Respiratory failure 118.36 14.45 535 81147 108037 34767212
Encephalopathy 117.65 14.45 257 81425 35062 34840187
Tremor 117.06 14.45 25 81657 82562 34792687
Drug interaction 116.84 14.45 219 81463 225727 34649522
Rash 115.09 14.45 216 81466 222536 34652713
Stem cell transplant 114.53 14.45 68 81614 2071 34873178
Joint swelling 112.08 14.45 7 81675 59883 34815366
Platelet count decreased 111.01 14.45 563 81119 119154 34756095
Peripheral swelling 110.90 14.45 22 81660 76519 34798730
Neoplasm recurrence 108.83 14.45 67 81615 2182 34873067
Hypogammaglobulinaemia 106.73 14.45 110 81572 7630 34867619
Inappropriate schedule of product administration 103.73 14.45 12 81670 62284 34812965
Progressive multifocal leukoencephalopathy 97.14 14.45 117 81565 9647 34865602
Acute graft versus host disease 96.20 14.45 96 81586 6407 34868842
Hepatitis B reactivation 94.49 14.45 76 81606 3815 34871434
BK virus infection 92.90 14.45 89 81593 5649 34869600
Somnolence 90.48 14.45 76 81606 111040 34764209
Pruritus 88.99 14.45 121 81561 141860 34733389
White blood cell count decreased 87.13 14.45 447 81235 94998 34780251
Clostridium difficile colitis 85.39 14.45 141 81541 15589 34859660
Lymphadenopathy 84.62 14.45 198 81484 28265 34846984
Drug resistance 84.45 14.45 187 81495 25740 34849509
Nasopharyngitis 84.45 14.45 29 81653 69939 34805310
Neuropathy peripheral 83.11 14.45 400 81282 82863 34792386
Cardiac failure congestive 80.94 14.45 47 81635 83223 34792026
Musculoskeletal stiffness 80.24 14.45 8 81674 46672 34828577
Headache 79.75 14.45 224 81458 200411 34674838
Colitis 78.76 14.45 230 81452 37520 34837729
Nephropathy toxic 78.19 14.45 120 81562 12468 34862781
Anaplastic lymphoma kinase gene mutation 77.54 14.45 23 81659 103 34875146
Feeling abnormal 76.67 14.45 26 81656 63209 34812040
Weight increased 76.50 14.45 63 81619 92970 34782279
Cytomegalovirus infection 75.73 14.45 180 81502 25955 34849294
Neurotoxicity 74.06 14.45 143 81539 17867 34857382
Coronary artery disease 74.04 14.45 12 81670 48293 34826956
Lymphopenia 73.77 14.45 135 81547 16200 34859049
Therapy non-responder 73.66 14.45 230 81452 38916 34836333
Epstein-Barr virus infection 73.59 14.45 90 81592 7538 34867711
Pulmonary toxicity 73.50 14.45 81 81601 6066 34869183
Hospitalisation 73.28 14.45 21 81661 56881 34818368
Drug ineffective 73.20 14.45 1483 80199 455268 34419981
Enterococcal bacteraemia 73.18 14.45 49 81633 1848 34873401
Sweat gland tumour 72.30 14.45 30 81652 409 34874840
Muscle spasms 71.94 14.45 43 81639 74958 34800291
B-cell lymphoma recurrent 69.25 14.45 35 81647 769 34874480
Asthma 69.08 14.45 9 81673 42647 34832602
Aggression 68.77 14.45 6 81676 38958 34836291
Blood glucose increased 68.70 14.45 35 81647 66683 34808566
Myocardial infarction 68.25 14.45 111 81571 120974 34754275
Incorrect dose administered 66.95 14.45 8 81674 40507 34834742
Agranulocytosis 66.80 14.45 162 81520 23659 34851590
Hepatitis B 66.68 14.45 76 81606 5907 34869342
Myalgia 66.66 14.45 59 81623 84051 34791198
Osteosarcoma 65.63 14.45 25 81657 268 34874981
Enterococcal infection 65.39 14.45 94 81588 9212 34866037
Candida infection 64.86 14.45 134 81548 17581 34857668
Staphylococcal bacteraemia 64.77 14.45 89 81593 8363 34866886
Cytomegalovirus chorioretinitis 64.51 14.45 59 81623 3530 34871719
Weight decreased 64.15 14.45 205 81477 176096 34699153
Systemic mycosis 64.00 14.45 42 81640 1531 34873718
Engraftment syndrome 62.17 14.45 35 81647 962 34874287
Multiple organ dysfunction syndrome 61.95 14.45 347 81335 76219 34799030
Chest pain 60.98 14.45 128 81554 126634 34748615
Abdominal discomfort 60.70 14.45 32 81650 59803 34815446
Diffuse large B-cell lymphoma 60.12 14.45 80 81602 7290 34867959
Rhabdomyolysis 60.05 14.45 43 81639 68120 34807129
Death 58.83 14.45 621 81061 397428 34477821
Acute promyelocytic leukaemia 58.70 14.45 27 81655 478 34874771
Renal tubular disorder 58.69 14.45 63 81619 4580 34870669
Thrombotic microangiopathy 58.66 14.45 96 81586 10534 34864715
Drug hypersensitivity 57.43 14.45 62 81620 80467 34794782
Adenovirus infection 57.27 14.45 66 81616 5191 34870058
Klebsiella infection 56.78 14.45 84 81598 8447 34866802
Cerebrovascular accident 56.48 14.45 69 81613 84742 34790507
Pneumonitis 56.47 14.45 191 81491 33687 34841562
Sleep disorder 55.60 14.45 5 81677 31683 34843566
Gastrointestinal toxicity 55.43 14.45 48 81634 2671 34872578
Chronic graft versus host disease 54.68 14.45 59 81623 4314 34870935
Bacterial infection 54.36 14.45 122 81560 16941 34858308
Retinal haemorrhage 53.95 14.45 63 81619 5026 34870223
Lymphoma 53.51 14.45 101 81581 12406 34862843
Gait disturbance 52.85 14.45 73 81609 85067 34790182
Influenza like illness 52.39 14.45 3 81679 27631 34847618
Balance disorder 52.35 14.45 15 81667 40639 34834610
Hyperhidrosis 52.09 14.45 60 81622 75632 34799617
Pneumocystis jirovecii pneumonia 52.04 14.45 131 81551 19579 34855670
Pain in extremity 51.88 14.45 139 81543 126374 34748875
Bradycardia 51.66 14.45 60 81622 75358 34799891
Hallucination 51.56 14.45 28 81654 51470 34823779
Chloroma 51.55 14.45 25 81657 501 34874748
Rheumatoid arthritis 51.33 14.45 13 81669 38225 34837024
Graft versus host disease 51.11 14.45 90 81592 10479 34864770
Hyperkalaemia 51.08 14.45 52 81630 69337 34805912
Heart rate decreased 50.68 14.45 7 81675 31738 34843511
Acute myeloid leukaemia recurrent 49.77 14.45 41 81641 2129 34873120
Acute graft versus host disease in skin 49.58 14.45 61 81621 5140 34870109
Diabetes mellitus 49.14 14.45 24 81658 46849 34828400
Epstein-Barr virus associated lymphoproliferative disorder 49.05 14.45 39 81643 1925 34873324
Refractory cancer 48.58 14.45 17 81665 140 34875109
Urticaria 47.93 14.45 45 81637 62332 34812917
Nephrolithiasis 47.70 14.45 7 81675 30326 34844923
Bacterial sepsis 47.53 14.45 60 81622 5190 34870059
Blood stem cell transplant failure 47.30 14.45 22 81660 400 34874849
Ameloblastoma 47.09 14.45 15 81667 89 34875160
Azoospermia 46.38 14.45 22 81660 419 34874830
Dyspnoea 46.30 14.45 612 81070 376170 34499079
Vision blurred 46.00 14.45 25 81657 45938 34829311
Vena cava thrombosis 45.79 14.45 31 81651 1191 34874058
Pneumonia klebsiella 45.67 14.45 47 81635 3253 34871996
Loss of personal independence in daily activities 45.08 14.45 11 81671 33168 34842081
Pulmonary vascular disorder 45.01 14.45 25 81657 669 34874580
Drug dependence 44.79 14.45 3 81679 24214 34851035
Drug reaction with eosinophilia and systemic symptoms 44.74 14.45 11 81671 33001 34842248
Acute respiratory distress syndrome 44.68 14.45 148 81534 25821 34849428
Thymus hypoplasia 44.41 14.45 21 81661 397 34874852
Lymphoid tissue hypoplasia 44.41 14.45 21 81661 397 34874852
Chronic obstructive pulmonary disease 44.22 14.45 30 81652 48888 34826361
Diaphragm muscle weakness 44.09 14.45 16 81666 148 34875101
Neoplasm 44.06 14.45 59 81623 5408 34869841
Unevaluable event 43.89 14.45 11 81671 32579 34842670
Oedema peripheral 43.76 14.45 139 81543 119673 34755576
Prostate cancer 43.58 14.45 19 81663 39630 34835619
Escherichia infection 43.53 14.45 73 81609 8172 34867077
Salivary gland cancer 43.22 14.45 19 81663 301 34874948
Papillary thyroid cancer 43.12 14.45 24 81658 645 34874604
Urinary tract infection 42.90 14.45 82 81600 83999 34791250
Electrocardiogram QT prolonged 42.88 14.45 21 81661 40931 34834318
Loss of consciousness 42.72 14.45 80 81602 82587 34792662
Memory impairment 42.71 14.45 24 81658 43294 34831955
Back pain 42.61 14.45 144 81538 121645 34753604
Psoriasis 42.02 14.45 19 81663 38793 34836456
Central nervous system fungal infection 41.59 14.45 19 81663 331 34874918
Haematochezia 41.45 14.45 29 81653 46505 34828744
Arthritis 41.41 14.45 11 81671 31335 34843914
Pulmonary arteriopathy 40.97 14.45 13 81669 76 34875173
Angioedema 40.93 14.45 18 81664 37356 34837893
Cytomegalovirus viraemia 40.86 14.45 67 81615 7363 34867886
Wheezing 40.73 14.45 23 81659 41379 34833870
Recurrent cancer 40.01 14.45 30 81652 1357 34873892
Blood creatine phosphokinase increased 39.89 14.45 28 81654 44829 34830420
Acute lymphocytic leukaemia 39.88 14.45 42 81640 2987 34872262
Klebsiella sepsis 39.60 14.45 35 81647 2002 34873247
Cardiac disorder 39.58 14.45 26 81656 43100 34832149
Pulmonary veno-occlusive disease 39.50 14.45 21 81661 514 34874735
Hypoglycaemia 39.02 14.45 42 81640 54598 34820651
Epstein-Barr virus infection reactivation 38.98 14.45 27 81655 1077 34874172
Metastases to central nervous system 38.55 14.45 69 81613 8136 34867113
Metastasis 38.53 14.45 48 81634 4096 34871153
Fusarium infection 37.78 14.45 27 81655 1133 34874116
Contusion 37.54 14.45 19 81663 36345 34838904
Mucormycosis 37.40 14.45 57 81625 5885 34869364
Ototoxicity 37.39 14.45 33 81649 1884 34873365
Viral haemorrhagic cystitis 37.36 14.45 27 81655 1153 34874096
Aortic thrombosis 37.19 14.45 23 81659 755 34874494
Swelling 36.95 14.45 27 81655 42339 34832910
Blood pressure systolic increased 36.78 14.45 5 81677 22947 34852302
Metastases to meninges 36.59 14.45 29 81653 1425 34873824
Spinal column injury 36.48 14.45 21 81661 603 34874646
Osteonecrosis 36.25 14.45 96 81586 14794 34860455
Abdominal pain upper 36.22 14.45 70 81612 71420 34803829
Gastrooesophageal reflux disease 35.99 14.45 22 81660 37902 34837347
Leukaemia recurrent 35.97 14.45 30 81652 1585 34873664
Toxicity to various agents 35.73 14.45 298 81384 200064 34675185
Teratoma 35.38 14.45 9 81673 19 34875230
Serotonin syndrome 35.36 14.45 3 81679 19930 34855319
Medulloblastoma recurrent 35.15 14.45 11 81671 61 34875188
Metastases to lung 34.70 14.45 71 81611 9249 34866000
Lactic acidosis 34.67 14.45 19 81663 34753 34840496
Systemic candida 34.39 14.45 43 81639 3683 34871566
Injury 34.38 14.45 4 81678 20683 34854566
Pneumonia adenoviral 34.20 14.45 17 81665 360 34874889
Graft versus host disease in skin 34.18 14.45 44 81638 3881 34871368
Escherichia bacteraemia 33.76 14.45 40 81642 3240 34872009
Juvenile melanoma benign 33.75 14.45 11 81671 71 34875178
Adenoviral hepatitis 33.66 14.45 19 81663 525 34874724
Pseudomonas infection 33.42 14.45 83 81599 12299 34862950
Graft versus host disease in gastrointestinal tract 33.19 14.45 42 81640 3641 34871608
Eosinophilia 33.16 14.45 10 81672 26212 34849037
Graft versus host disease in liver 33.15 14.45 26 81656 1258 34873991
Ganglioneuroblastoma 33.14 14.45 9 81673 27 34875222
Retinopathy proliferative 33.11 14.45 11 81671 76 34875173
Drug ineffective for unapproved indication 32.95 14.45 126 81556 23589 34851660
Sedation 32.68 14.45 5 81677 21001 34854248
Disturbance in attention 32.62 14.45 10 81672 25935 34849314
Wrong technique in product usage process 32.61 14.45 22 81660 35964 34839285
Bronchitis 32.55 14.45 30 81652 41933 34833316
Influenza 32.43 14.45 41 81641 49625 34825624
Fanconi syndrome 32.33 14.45 29 81653 1691 34873558
Dry mouth 32.29 14.45 15 81667 30150 34845099
Mobility decreased 32.23 14.45 15 81667 30113 34845136
Hepatotoxicity 32.22 14.45 117 81565 21368 34853881
Carotid artery thrombosis 32.18 14.45 16 81666 339 34874910
Metastases to liver 32.16 14.45 87 81595 13576 34861673
Disseminated aspergillosis 32.15 14.45 21 81661 759 34874490
Cytomegalovirus infection reactivation 32.07 14.45 49 81633 5069 34870180
Erectile dysfunction 31.90 14.45 5 81677 20632 34854617
Blood cholesterol increased 31.70 14.45 5 81677 20538 34854711
Paraneoplastic neurological syndrome 31.15 14.45 9 81673 36 34875213
Cellulitis gangrenous 31.15 14.45 13 81669 180 34875069
Pulmonary haemorrhage 30.96 14.45 72 81610 10232 34865017
Adverse drug reaction 30.78 14.45 15 81667 29327 34845922
Rhabdomyosarcoma recurrent 30.48 14.45 11 81671 100 34875149
Neuroblastoma 30.45 14.45 13 81669 191 34875058
Neuroblastoma recurrent 30.15 14.45 12 81670 146 34875103
Mantle cell lymphoma recurrent 30.14 14.45 20 81662 743 34874506
Treatment noncompliance 30.04 14.45 14 81668 28086 34847163
Migraine 30.02 14.45 3 81679 17475 34857774
Extravasation 30.00 14.45 29 81653 1861 34873388
Cytogenetic abnormality 29.54 14.45 21 81661 874 34874375
Dyskinesia 29.35 14.45 8 81674 22405 34852844
Delayed puberty 29.12 14.45 13 81669 214 34875035
Enteritis 29.11 14.45 61 81621 8081 34867168
Herpes simplex 29.05 14.45 49 81633 5510 34869739
Minimal residual disease 29.05 14.45 16 81666 421 34874828
Abnormal behaviour 29.00 14.45 11 81671 24958 34850291
Cardio-respiratory arrest 28.98 14.45 53 81629 55220 34820029
Therapy cessation 28.92 14.45 3 81679 16970 34858279
T-cell type acute leukaemia 28.87 14.45 11 81671 118 34875131
Skin toxicity 28.86 14.45 45 81637 4739 34870510
Accidental overdose 28.71 14.45 6 81676 20134 34855115
Hepatic candidiasis 28.60 14.45 9 81673 51 34875198
Dry skin 28.52 14.45 19 81663 31268 34843981
Radiation pneumonitis 28.52 14.45 33 81649 2607 34872642
Heart rate increased 28.48 14.45 40 81642 46303 34828946
Toxic encephalopathy 28.41 14.45 47 81635 5202 34870047
Pseudomonal bacteraemia 28.37 14.45 25 81657 1424 34873825
Body height below normal 28.32 14.45 13 81669 229 34875020
Myelopathy 28.30 14.45 32 81650 2465 34872784
Metastases to muscle 28.17 14.45 13 81669 232 34875017
Dehydration 28.09 14.45 183 81499 129786 34745463
Aspiration bone marrow abnormal 28.00 14.45 11 81671 129 34875120
Metastases to spleen 27.99 14.45 16 81666 453 34874796
Disseminated intravascular coagulation 27.95 14.45 113 81569 21703 34853546
Infection 27.87 14.45 330 81352 90585 34784664
Peripheral T-cell lymphoma unspecified 27.84 14.45 16 81666 458 34874791
Transient ischaemic attack 27.65 14.45 15 81667 27598 34847651
Human herpesvirus 6 infection 27.65 14.45 29 81653 2052 34873197
Metastases to retroperitoneum 27.62 14.45 13 81669 243 34875006
Hepatic infection fungal 27.47 14.45 12 81670 187 34875062
Skin exfoliation 27.33 14.45 15 81667 27417 34847832
Stenotrophomonas infection 27.32 14.45 29 81653 2081 34873168
Embolism 27.23 14.45 58 81624 7771 34867478
Hypoalbuminaemia 27.15 14.45 76 81606 12098 34863151
Refractory anaemia with an excess of blasts 26.99 14.45 15 81667 402 34874847
Liver function test abnormal 26.84 14.45 20 81662 31054 34844195
Encephalitis enteroviral 26.78 14.45 11 81671 146 34875103
Head injury 26.75 14.45 5 81677 18155 34857094
Hyperbilirubinaemia 26.35 14.45 93 81589 16750 34858499
Amnesia 25.78 14.45 15 81667 26548 34848701
Abdominal distension 25.70 14.45 62 81620 58430 34816819
Flagellate dermatitis 25.63 14.45 9 81673 75 34875174
Medication error 25.44 14.45 14 81668 25551 34849698
Flatulence 25.19 14.45 9 81673 21189 34854060
Device related infection 25.12 14.45 93 81589 17144 34858105
Agitation 25.09 14.45 61 81621 57338 34817911
Aplastic anaemia 25.04 14.45 64 81618 9652 34865597
Intestinal atresia 25.02 14.45 9 81673 81 34875168
Candida sepsis 24.91 14.45 22 81660 1257 34873992
Streptococcal bacteraemia 24.87 14.45 27 81655 1988 34873261
Acute lymphocytic leukaemia recurrent 24.76 14.45 33 81649 3011 34872238
Diverticulitis 24.63 14.45 8 81674 19996 34855253
Peripheral sensory neuropathy 24.58 14.45 51 81631 6709 34868540
Therapeutic product effect decreased 24.48 14.45 27 81655 34716 34840533
Diabetic ketoacidosis 24.45 14.45 6 81676 18026 34857223
Paraesthesia 24.44 14.45 73 81609 64099 34811150
Faeces discoloured 24.42 14.45 3 81679 14875 34860374
Cytokine release syndrome 24.32 14.45 112 81570 22765 34852484
International normalised ratio increased 24.26 14.45 46 81636 47281 34827968
Short stature 24.18 14.45 9 81673 90 34875159
Myeloid leukaemia 24.10 14.45 14 81668 409 34874840
Vertigo 23.97 14.45 15 81667 25521 34849728
Blood electrolytes abnormal 23.70 14.45 19 81663 949 34874300
Varicella zoster virus infection 23.70 14.45 25 81657 1781 34873468
Chromaturia 23.66 14.45 3 81679 14517 34860732
Confusional state 23.64 14.45 219 81463 143941 34731308
Benign prostatic hyperplasia 23.60 14.45 3 81679 14492 34860757
Arterial thrombosis 23.58 14.45 23 81659 1492 34873757
Rectal haemorrhage 23.50 14.45 36 81646 40213 34835036
Basal cell naevus syndrome 23.48 14.45 7 81675 32 34875217
Nervous system disorder 23.35 14.45 81 81601 14462 34860787
Road traffic accident 23.28 14.45 6 81676 17444 34857805
Intussusception 23.28 14.45 16 81666 630 34874619
Condition aggravated 23.21 14.45 313 81369 191883 34683366
Traumatic lung injury 23.21 14.45 21 81661 1239 34874010
Leukoencephalopathy 23.16 14.45 38 81644 4177 34871072
Hypertensive hydrocephalus 23.06 14.45 8 81674 64 34875185
Papilloedema 22.98 14.45 30 81652 2683 34872566
Adenovirus reactivation 22.93 14.45 11 81671 215 34875034
Speech disorder 22.88 14.45 16 81666 25670 34849579
Pneumonia fungal 22.87 14.45 51 81631 7049 34868200
Syncope 22.80 14.45 123 81559 91328 34783921
Gastrointestinal mucosal disorder 22.78 14.45 13 81669 367 34874882
Central nervous system lymphoma 22.70 14.45 19 81663 1009 34874240
Psoriatic arthropathy 22.54 14.45 9 81673 19789 34855460
Metastases to lymph nodes 22.52 14.45 40 81642 4688 34870561
Meningitis tuberculous 22.44 14.45 16 81666 669 34874580
Emotional distress 22.43 14.45 4 81678 15022 34860227
Nasal congestion 22.40 14.45 13 81669 23044 34852205
Capillary leak syndrome 22.36 14.45 27 81655 2231 34873018
Post-acute COVID-19 syndrome 22.22 14.45 10 81672 168 34875081
Pneumothorax 22.20 14.45 96 81586 18996 34856253
Pneumonia aspiration 22.13 14.45 40 81642 41863 34833386
Brain sarcoma 22.09 14.45 6 81676 18 34875231
Carbamoyl phosphate synthetase deficiency 22.09 14.45 6 81676 18 34875231
Laboratory test abnormal 22.04 14.45 10 81672 20381 34854868
B-cell lymphoma refractory 21.95 14.45 10 81672 173 34875076
Ill-defined disorder 21.93 14.45 77 81605 13832 34861417
Arrhythmia 21.91 14.45 31 81651 35777 34839472
Therapy interrupted 21.91 14.45 3 81679 13694 34861555
Cardiogenic shock 21.89 14.45 18 81664 26600 34848649
Geotrichum infection 21.84 14.45 14 81668 490 34874759
Myoclonus 21.81 14.45 4 81678 14721 34860528
Eczema 21.62 14.45 8 81674 18428 34856821
Klebsiella bacteraemia 21.47 14.45 21 81661 1367 34873882
Trichosporon infection 21.45 14.45 16 81666 718 34874531
Dyspnoea exertional 21.38 14.45 43 81639 43236 34832013
Hypertransaminasaemia 21.22 14.45 43 81639 5563 34869686
Gait inability 21.19 14.45 11 81671 20747 34854502
Hepatic cirrhosis 21.18 14.45 7 81675 17307 34857942
Streptococcal infection 21.14 14.45 40 81642 4921 34870328
Product administration error 21.09 14.45 6 81676 16338 34858911
Stomatitis necrotising 21.07 14.45 8 81674 85 34875164
Cerebral venous thrombosis 21.06 14.45 16 81666 738 34874511
Clostridium colitis 21.01 14.45 20 81662 1259 34873990
Small cell lung cancer 20.89 14.45 24 81658 1881 34873368
Hepatosplenomegaly 20.80 14.45 36 81646 4133 34871116
Transformation to acute myeloid leukaemia 20.69 14.45 16 81666 758 34874491
Autoimmune neutropenia 20.66 14.45 11 81671 270 34874979
Ventricular tachycardia 20.61 14.45 19 81663 26560 34848689
Osteonecrosis of jaw 20.58 14.45 8 81674 17881 34857368
Palpitations 20.38 14.45 39 81643 39947 34835302
Electrolyte imbalance 20.37 14.45 77 81605 14335 34860914
Escherichia sepsis 20.13 14.45 38 81644 4666 34870583
Disorder of orbit 20.12 14.45 8 81674 97 34875152
Blood pressure decreased 20.05 14.45 58 81624 51457 34823792
Adrenocortical carcinoma 20.03 14.45 6 81676 28 34875221
Lung infiltration 19.97 14.45 71 81611 12834 34862415
Granulocyte count decreased 19.96 14.45 16 81666 799 34874450
Cardiac arrest 19.96 14.45 137 81545 96022 34779227
Gallbladder empyema 19.86 14.45 7 81675 59 34875190
Hepatic steatosis 19.86 14.45 9 81673 18353 34856896
Inflammatory pseudotumour 19.86 14.45 6 81676 29 34875220
Platelet count abnormal 19.77 14.45 29 81653 2893 34872356
Intestinal perforation 19.65 14.45 56 81626 9004 34866245
Bicytopenia 19.63 14.45 26 81656 2358 34872891
Swollen tongue 19.53 14.45 5 81677 14600 34860649
Testicular malignant teratoma 19.52 14.45 5 81677 11 34875238
Neutrophil count abnormal 19.26 14.45 23 81659 1879 34873370
Paternal exposure timing unspecified 19.22 14.45 6 81676 33 34875216
Nightmare 19.10 14.45 5 81677 14386 34860863
Superior vena cava syndrome 18.99 14.45 14 81668 617 34874632
Therapy responder 18.85 14.45 9 81673 174 34875075
Enterocolitis 18.78 14.45 51 81631 7975 34867274
Type 2 diabetes mellitus 18.73 14.45 7 81675 16025 34859224
Chronic myelomonocytic leukaemia 18.54 14.45 14 81668 640 34874609
Burning sensation 18.41 14.45 10 81672 18384 34856865
Small intestinal perforation 18.38 14.45 24 81658 2147 34873102
Heart rate irregular 18.30 14.45 7 81675 15800 34859449
Acute myelomonocytic leukaemia 18.30 14.45 8 81674 125 34875124
Asthenia 18.27 14.45 435 81247 244816 34630433
Arteriosclerosis 18.27 14.45 3 81679 11965 34863284
Flushing 18.20 14.45 134 81548 32286 34842963
Hip fracture 18.18 14.45 3 81679 11922 34863327
Spindle cell sarcoma 18.18 14.45 8 81674 127 34875122
Polyneuropathy 18.17 14.45 76 81606 14820 34860429
Hypokalaemia 18.14 14.45 212 81470 58002 34817247
Neurological decompensation 18.03 14.45 28 81654 2938 34872311
Obesity 18.02 14.45 4 81678 12874 34862375
Dystrophic calcification 18.01 14.45 4 81678 3 34875246
Hypoaesthesia 18.01 14.45 78 81604 61366 34813883
Premature ageing 17.98 14.45 7 81675 80 34875169
Reticulocytosis 17.92 14.45 10 81672 270 34874979
Chronic myeloid leukaemia 17.92 14.45 24 81658 2200 34873049
Plasma cell leukaemia 17.91 14.45 16 81666 928 34874321
Refractory cytopenia with multilineage dysplasia 17.90 14.45 8 81674 132 34875117
Blood fibrinogen decreased 17.90 14.45 18 81664 1212 34874037
Underdose 17.89 14.45 5 81677 13775 34861474
Post transplant lymphoproliferative disorder 17.87 14.45 44 81638 6484 34868765
Accidental exposure to product 17.87 14.45 4 81678 12798 34862451
Pulmonary alveolar haemorrhage 17.85 14.45 48 81634 7464 34867785
Adverse event 17.84 14.45 11 81671 18866 34856383
Fluid retention 17.75 14.45 22 81660 26865 34848384
5q minus syndrome 17.53 14.45 8 81674 139 34875110
Mucoepidermoid carcinoma 17.51 14.45 5 81677 19 34875230
Peripheral sensorimotor neuropathy 17.47 14.45 20 81662 1562 34873687
Pneumonia cytomegaloviral 17.42 14.45 28 81654 3026 34872223
Treatment failure 17.29 14.45 176 81506 46521 34828728
Hypertension 17.26 14.45 220 81462 136223 34739026
Pneumocystis jirovecii infection 17.26 14.45 21 81661 1749 34873500
Pancreatitis 17.26 14.45 41 81641 38850 34836399
Blindness cortical 17.23 14.45 11 81671 382 34874867
Myelitis transverse 17.17 14.45 17 81665 1123 34874126
Gout 17.14 14.45 12 81670 19241 34856008
Abdominal neoplasm 17.03 14.45 11 81671 390 34874859
Lower respiratory tract infection fungal 17.01 14.45 13 81669 605 34874644
Epstein-Barr viraemia 16.93 14.45 18 81664 1294 34873955
Retinal pigment epitheliopathy 16.90 14.45 9 81673 221 34875028
Drug level increased 16.89 14.45 16 81666 22080 34853169
Adenomatous polyposis coli 16.88 14.45 8 81674 152 34875097
Scedosporium infection 16.84 14.45 15 81667 867 34874382
Chemotherapy 16.81 14.45 13 81669 616 34874633
Terminal ileitis 16.79 14.45 9 81673 224 34875025
Thrombosis 16.72 14.45 61 81621 50397 34824852
Hepatic enzyme increased 16.71 14.45 42 81640 39038 34836211
Guillain-Barre syndrome 16.63 14.45 41 81641 6046 34869203
Discomfort 16.60 14.45 12 81670 18926 34856323
Acanthamoeba infection 16.59 14.45 11 81671 408 34874841
Sopor 16.53 14.45 4 81678 12132 34863117
Wound 16.52 14.45 7 81675 14857 34860392
Angina pectoris 16.50 14.45 30 81652 31333 34843916
Atrial fibrillation 16.36 14.45 195 81487 122198 34753051
Metastases to bone marrow 16.33 14.45 12 81670 526 34874723
Embolism arterial 16.31 14.45 13 81669 644 34874605
Septal panniculitis 16.30 14.45 6 81676 58 34875191
Peritoneal lesion 16.27 14.45 7 81675 105 34875144
Renal infarct 16.22 14.45 18 81664 1358 34873891
Atypical teratoid/rhabdoid tumour of CNS 16.22 14.45 4 81678 7 34875242
Burns first degree 16.22 14.45 4 81678 7 34875242
Cardiomyopathy 16.20 14.45 80 81602 16728 34858521
Prostatic specific antigen increased 16.18 14.45 7 81675 14673 34860576
Toxic epidermal necrolysis 16.17 14.45 16 81666 21630 34853619
Psychotic disorder 16.15 14.45 20 81662 24432 34850817
Metastases to bone 16.13 14.45 63 81619 11907 34863342
Splenic infarction 16.12 14.45 22 81660 2053 34873196
Testicular germ cell cancer metastatic 16.12 14.45 6 81676 60 34875189
Chest discomfort 16.12 14.45 69 81613 54461 34820788
Stevens-Johnson syndrome 16.09 14.45 12 81670 18627 34856622
Neuroendocrine tumour of the lung metastatic 16.09 14.45 7 81675 108 34875141
Colony stimulating factor therapy 16.07 14.45 8 81674 170 34875079
Delirium 16.06 14.45 51 81631 43940 34831309
Pneumatosis intestinalis 15.94 14.45 31 81651 3892 34871357
Rhinorrhoea 15.92 14.45 22 81660 25646 34849603
Carnitine deficiency 15.92 14.45 7 81675 111 34875138
Hyperlipidaemia 15.90 14.45 7 81675 14522 34860727
Choriocarcinoma 15.87 14.45 4 81678 8 34875241
Cerebellar tumour 15.86 14.45 6 81676 63 34875186
Mucosal toxicity 15.84 14.45 9 81673 252 34874997
Poikiloderma 15.82 14.45 8 81674 176 34875073
Haemorrhage 15.80 14.45 64 81618 51306 34823943
Delayed engraftment 15.80 14.45 7 81675 113 34875136
Congenital hepatobiliary anomaly 15.79 14.45 5 81677 29 34875220
Deafness 15.77 14.45 60 81622 11205 34864044
Bacillus bacteraemia 15.70 14.45 6 81676 65 34875184
Primitive neuroectodermal tumour 15.70 14.45 6 81676 65 34875184
Recall phenomenon 15.69 14.45 12 81670 559 34874690
Hypomagnesaemia 15.68 14.45 96 81586 21755 34853494
Medulloblastoma 15.61 14.45 6 81676 66 34875183
Localised infection 15.60 14.45 11 81671 17576 34857673
Acute monocytic leukaemia 15.57 14.45 10 81672 351 34874898
Diabetes mellitus inadequate control 15.52 14.45 6 81676 13458 34861791
Clostridium difficile infection 15.49 14.45 86 81596 18812 34856437
Tooth hypoplasia 15.48 14.45 7 81675 119 34875130
Coronary artery thrombosis 15.45 14.45 22 81660 2137 34873112
Hepatic necrosis 15.44 14.45 30 81652 3764 34871485
Skin laceration 15.40 14.45 5 81677 12504 34862745
Hirsutism 15.38 14.45 8 81674 187 34875062
Cholelithiasis 15.38 14.45 16 81666 21132 34854117
Peripheral artery thrombosis 15.36 14.45 23 81659 2337 34872912
Pneumomediastinum 15.31 14.45 23 81659 2344 34872905
Fanconi syndrome acquired 15.30 14.45 21 81661 1970 34873279
Bone sarcoma 15.30 14.45 6 81676 70 34875179
Autoimmune haemolytic anaemia 15.28 14.45 33 81649 4463 34870786
Ewing's sarcoma recurrent 15.26 14.45 4 81678 10 34875239
Subdural haemorrhage 15.20 14.45 27 81655 3164 34872085
Li-Fraumeni syndrome 15.18 14.45 3 81679 0 34875249
Erythema ab igne 15.18 14.45 3 81679 0 34875249
Salivary gland cancer stage IV 15.12 14.45 5 81677 34 34875215
Blood glucose decreased 15.09 14.45 6 81676 13231 34862018
Primary hypogonadism 15.07 14.45 6 81676 73 34875176
Blastic plasmacytoid dendritic cell neoplasia 15.07 14.45 6 81676 73 34875176
JC virus infection 15.07 14.45 22 81660 2186 34873063
CNS ventriculitis 15.01 14.45 9 81673 279 34874970
Blood culture positive 15.01 14.45 34 81648 4749 34870500
Metastatic lymphoma 15.00 14.45 8 81674 197 34875052
Epidural haemorrhage 15 14.45 6 81676 74 34875175
Staphylococcal infection 14.89 14.45 129 81553 32631 34842618
Iron deficiency anaemia 14.88 14.45 3 81679 10326 34864923
Cardiomyopathy acute 14.87 14.45 5 81677 36 34875213
Lethargy 14.79 14.45 48 81634 41074 34834175
Food protein-induced enterocolitis syndrome 14.75 14.45 5 81677 37 34875212
Subcutaneous emphysema 14.74 14.45 16 81666 1178 34874071
Alpha haemolytic streptococcal infection 14.74 14.45 16 81666 1178 34874071
Mediastinum neoplasm 14.73 14.45 4 81678 12 34875237
Platelet transfusion 14.71 14.45 18 81664 1508 34873741
Immune effector cell-associated neurotoxicity syndrome 14.67 14.45 29 81653 3684 34871565
Cerebral artery occlusion 14.66 14.45 13 81669 747 34874502
Nocturia 14.64 14.45 3 81679 10207 34865042
Paranoia 14.55 14.45 5 81677 12063 34863186
Vascular device infection 14.55 14.45 31 81651 4154 34871095
Cerebral toxoplasmosis 14.53 14.45 19 81663 1702 34873547
Pulmonary congestion 14.49 14.45 7 81675 13758 34861491
Dementia 14.46 14.45 7 81675 13741 34861508

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 5815.59 14.56 3961 125001 227038 79388388
Neutropenia 2065.51 14.56 2429 126533 285281 79330145
Pancytopenia 1660.87 14.56 1670 127292 164075 79451351
Mucosal inflammation 1638.05 14.56 1187 127775 74393 79541033
Bone marrow failure 1404.15 14.56 929 128033 50178 79565248
Thrombocytopenia 1281.89 14.56 1844 127118 263415 79352011
Disease progression 1277.92 14.56 1531 127431 182831 79432595
Acute myeloid leukaemia 1128.78 14.56 673 128289 30212 79585214
Off label use 1073.84 14.56 3553 125409 903662 78711764
Product use in unapproved indication 1046.71 14.56 1627 127335 248732 79366694
Myelosuppression 1026.25 14.56 699 128263 39597 79575829
Myelodysplastic syndrome 975.87 14.56 609 128353 29692 79585734
Haematotoxicity 843.07 14.56 439 128523 15080 79600346
Venoocclusive liver disease 777.20 14.56 380 128582 11391 79604035
Malignant neoplasm progression 729.18 14.56 995 127967 134995 79480431
Sepsis 661.76 14.56 1390 127572 268038 79347388
Second primary malignancy 650.65 14.56 360 128602 13990 79601436
Tumour lysis syndrome 601.56 14.56 412 128550 23527 79591899
Septic shock 570.15 14.56 839 128123 121962 79493464
Neutrophil count decreased 556.43 14.56 722 128240 93237 79522189
Febrile bone marrow aplasia 529.00 14.56 304 128658 12716 79602710
Neutropenic sepsis 498.52 14.56 386 128576 26678 79588748
Pain 474.05 14.56 276 128686 703526 78911900
Arthralgia 467.31 14.56 171 128791 571632 79043794
Renal salt-wasting syndrome 447.42 14.56 122 128840 594 79614832
Haemophagocytic lymphohistiocytosis 440.90 14.56 329 128633 21508 79593918
Therapy partial responder 438.46 14.56 300 128662 17097 79598329
Joint swelling 415.38 14.56 11 128951 288635 79326791
Fall 411.71 14.56 138 128824 487491 79127935
Diffuse large B-cell lymphoma recurrent 403.45 14.56 176 128786 4031 79611395
Anaemia 367.76 14.56 1558 127404 443457 79171969
Aplasia 367.74 14.56 201 128761 7619 79607807
Posterior reversible encephalopathy syndrome 366.79 14.56 319 128643 25962 79589464
Stem cell transplant 342.38 14.56 151 128811 3553 79611873
Cytopenia 331.00 14.56 270 128692 20113 79595313
Leukopenia 329.34 14.56 638 128324 115875 79499551
Multiple organ dysfunction syndrome 321.22 14.56 643 128319 119603 79495823
Pyrexia 310.61 14.56 2016 126946 676693 78938733
Platelet count decreased 306.22 14.56 846 128116 193818 79421608
Neoplasm progression 302.43 14.56 395 128567 51287 79564139
Product dose omission issue 301.05 14.56 27 128935 247510 79367916
Encephalopathy 291.86 14.56 446 128516 66951 79548475
Cardiotoxicity 291.82 14.56 204 128758 12035 79603391
Nasopharyngitis 289.95 14.56 35 128927 253846 79361580
Peripheral swelling 287.16 14.56 46 128916 269571 79345855
Malignant transformation 286.90 14.56 98 128864 1120 79614306
Aspergillus infection 282.45 14.56 240 128722 18921 79596505
Bacteraemia 279.86 14.56 304 128658 32520 79582906
Rheumatoid arthritis 279.00 14.56 14 128948 208456 79406970
Neutropenic colitis 274.76 14.56 149 128813 5558 79609868
Abdominal discomfort 266.50 14.56 43 128919 250684 79364742
Headache 265.31 14.56 405 128557 653367 78962059
Bronchopulmonary aspergillosis 260.70 14.56 245 128717 22049 79593377
Malaise 259.68 14.56 246 128716 489623 79125803
Venoocclusive disease 258.76 14.56 133 128829 4440 79610986
Drug hypersensitivity 253.02 14.56 84 128878 298832 79316594
Arthropathy 250.10 14.56 8 128954 177103 79438323
Dizziness 243.84 14.56 296 128666 526145 79089281
Fatigue 241.22 14.56 740 128222 928987 78686439
Pruritus 240.23 14.56 173 128789 394475 79220951
Respiratory failure 238.17 14.56 738 128224 180173 79435253
Cystitis haemorrhagic 235.45 14.56 160 128802 9012 79606414
Musculoskeletal stiffness 233.38 14.56 12 128950 174996 79440430
Cytomegalovirus infection 223.61 14.56 309 128653 42335 79573091
Acute graft versus host disease 220.58 14.56 160 128802 10007 79605419
Rash 219.73 14.56 374 128588 577984 79037442
Disease recurrence 218.48 14.56 311 128651 43798 79571628
Insomnia 218.03 14.56 63 128899 245107 79370319
Weight increased 212.92 14.56 91 128871 277295 79338131
Drug abuse 211.25 14.56 13 128949 162678 79452748
Swelling 203.45 14.56 50 128912 216661 79398765
Overdose 201.62 14.56 29 128933 184177 79431249
Diffuse large B-cell lymphoma refractory 198.50 14.56 78 128884 1357 79614069
Drug resistance 197.93 14.56 290 128672 41923 79573503
Clostridium difficile colitis 195.49 14.56 251 128711 32032 79583394
Secondary immunodeficiency 194.46 14.56 98 128864 3136 79612290
Cytogenetic abnormality 191.00 14.56 71 128891 1054 79614372
Injection site pain 190.30 14.56 4 128958 129834 79485592
Bacterial infection 189.09 14.56 243 128719 31037 79584389
Human herpesvirus 6 infection 188.24 14.56 114 128848 5256 79610170
Anxiety 185.23 14.56 85 128877 248427 79366999
Blood pressure increased 179.47 14.56 59 128903 211301 79404125
Colitis 177.96 14.56 377 128585 72930 79542496
BK virus infection 171.80 14.56 130 128832 8674 79606752
Contraindicated product administered 169.63 14.56 26 128936 157512 79457914
Neuropathy peripheral 166.41 14.56 555 128407 140750 79474676
Asthma 166.17 14.56 14 128948 135081 79480345
Cytomegalovirus chorioretinitis 165.78 14.56 106 128856 5384 79610042
White blood cell count decreased 162.60 14.56 669 128293 187619 79427807
Wound 161.35 14.56 6 128956 116173 79499253
Candida infection 159.93 14.56 249 128713 37965 79577461
Neurotoxicity 159.15 14.56 228 128734 32290 79583136
Ototoxicity 159.06 14.56 86 128876 3188 79612238
Pain in extremity 154.20 14.56 219 128743 364319 79251107
Fungal infection 154.19 14.56 257 128705 41491 79573935
Lymphopenia 153.60 14.56 217 128745 30340 79585086
Therapeutic product effect decreased 149.56 14.56 40 128922 163823 79451603
Nephropathy toxic 146.61 14.56 173 128789 20246 79595180
Inappropriate schedule of product administration 146.29 14.56 21 128941 133607 79481819
Enterococcal infection 145.78 14.56 152 128810 15508 79599918
Contusion 144.21 14.56 32 128930 148744 79466682
Urticaria 143.26 14.56 60 128902 185141 79430285
Feeling abnormal 143.16 14.56 40 128922 159159 79456267
Cytomegalovirus viraemia 142.47 14.56 137 128825 12684 79602742
Graft versus host disease 141.95 14.56 147 128815 14879 79600547
Thrombotic microangiopathy 140.06 14.56 168 128794 20001 79595425
Muscle spasms 137.76 14.56 55 128907 174675 79440751
Hepatitis B reactivation 136.79 14.56 98 128864 6010 79609416
Teratoma 135.32 14.56 35 128927 133 79615293
Discomfort 134.62 14.56 21 128941 125596 79489830
Neoplasm recurrence 133.82 14.56 84 128878 4130 79611296
Pneumocystis jirovecii pneumonia 132.12 14.56 209 128753 32299 79583127
Klebsiella infection 126.03 14.56 141 128821 15579 79599847
Staphylococcal bacteraemia 123.55 14.56 124 128838 12094 79603332
Progressive multifocal leukoencephalopathy 122.88 14.56 159 128803 20441 79594985
Epstein-Barr virus infection 121.96 14.56 133 128829 14283 79601143
Thymus hypoplasia 117.64 14.56 48 128914 925 79614501
Hypersensitivity 116.42 14.56 152 128810 262087 79353339
Renal tubular disorder 116.12 14.56 91 128871 6395 79609031
Arthritis 114.84 14.56 23 128939 114857 79500569
Sweat gland tumour 114.73 14.56 40 128922 488 79614938
Stress 114.53 14.56 3 128959 79609 79535817
Drug intolerance 113.28 14.56 157 128805 263962 79351464
Mycobacterium chelonae infection 112.36 14.56 62 128900 2394 79613032
Glossodynia 111.35 14.56 17 128945 103320 79512106
Bronchitis 109.93 14.56 37 128925 130607 79484819
Somnolence 109.73 14.56 135 128827 238846 79376580
Lymphoid tissue hypoplasia 109.45 14.56 45 128917 885 79614541
Primary hypogonadism 108.22 14.56 30 128932 157 79615269
Depression 107.62 14.56 115 128847 216675 79398751
Ovarian germ cell teratoma 107.36 14.56 25 128937 53 79615373
Parainfluenzae virus infection 106.69 14.56 82 128880 5600 79609826
Blood lactate dehydrogenase increased 106.32 14.56 211 128751 38959 79576467
Loss of personal independence in daily activities 105.80 14.56 19 128943 102561 79512865
Suicidal ideation 105.79 14.56 4 128958 76336 79539090
Acute respiratory distress syndrome 105.04 14.56 225 128737 43842 79571584
Acute promyelocytic leukaemia 104.01 14.56 50 128912 1441 79613985
Blood cholesterol increased 102.06 14.56 9 128953 83711 79531715
Psoriatic arthropathy 101.92 14.56 6 128956 77993 79537433
Pseudomonal sepsis 100.67 14.56 82 128880 6092 79609334
Hepatic enzyme increased 99.73 14.56 89 128873 182521 79432905
Pulmonary haemorrhage 99.59 14.56 121 128841 14596 79600830
Injury 98.19 14.56 7 128955 77489 79537937
Migraine 97.52 14.56 13 128949 87480 79527946
Injection site erythema 96.43 14.56 8 128954 78189 79537237
Klebsiella sepsis 96.24 14.56 62 128900 3190 79612236
Blood pressure fluctuation 94.86 14.56 3 128959 67142 79548284
Osteosarcoma 94.45 14.56 32 128930 356 79615070
Human bocavirus infection 94.36 14.56 38 128924 707 79614719
Chronic graft versus host disease 93.96 14.56 82 128880 6699 79608727
Duodenal ulcer perforation 93.39 14.56 3 128959 66208 79549218
Gait disturbance 93.39 14.56 119 128843 207387 79408039
Chloroma 93.14 14.56 38 128924 732 79614694
Agranulocytosis 92.84 14.56 217 128745 44813 79570613
Aplastic anaemia 92.73 14.56 129 128833 17776 79597650
Myalgia 91.55 14.56 99 128863 185542 79429884
Suicide attempt 90.84 14.56 13 128949 82919 79532507
Tremor 90.38 14.56 85 128877 169998 79445428
Lymphadenopathy 90.16 14.56 238 128724 53009 79562417
Pneumatosis intestinalis 89.94 14.56 78 128884 6319 79609107
Influenza like illness 89.36 14.56 7 128955 71700 79543726
Mobility decreased 89.10 14.56 43 128919 122132 79493294
Hepatitis B 88.76 14.56 87 128875 8245 79607181
Anaplastic lymphoma kinase gene mutation 87.65 14.56 24 128938 119 79615307
Psoriasis 87.34 14.56 19 128943 89568 79525858
Abdominal pain upper 87.28 14.56 142 128820 223677 79391749
Incorrect dose administered 86.34 14.56 11 128951 76619 79538807
Pneumonitis 86.28 14.56 255 128707 60605 79554821
Enterobacter infection 86.01 14.56 66 128896 4496 79610930
Condition aggravated 85.90 14.56 468 128494 500656 79114770
Blister 85.69 14.56 43 128919 119433 79495993
Wheezing 85.17 14.56 41 128921 116623 79498803
Peripheral sensory neuropathy 84.71 14.56 105 128857 12928 79602498
Acute myeloid leukaemia recurrent 84.42 14.56 58 128904 3325 79612101
Adenovirus infection 84.07 14.56 85 128877 8362 79607064
Diffuse large B-cell lymphoma 84.03 14.56 101 128861 12048 79603378
Sinusitis 84.01 14.56 116 128846 195385 79420041
Urinary tract infection 83.90 14.56 201 128761 274311 79341115
Hypogammaglobulinaemia 83.63 14.56 104 128858 12847 79602579
Acute graft versus host disease in skin 83.52 14.56 81 128881 7577 79607849
Engraftment syndrome 82.68 14.56 42 128920 1367 79614059
Pulmonary toxicity 82.27 14.56 103 128859 12811 79602615
Disseminated intravascular coagulation 81.99 14.56 180 128782 35662 79579764
Sleep disorder 81.86 14.56 19 128943 85658 79529768
Metastases to central nervous system 81.86 14.56 116 128846 16259 79599167
Enteritis 81.47 14.56 109 128853 14474 79600952
Drug interaction 81.30 14.56 370 128592 414813 79200613
Weight decreased 81.15 14.56 298 128664 354900 79260526
Oesophagitis 81.10 14.56 143 128819 24146 79591280
Teratoma benign 80.70 14.56 20 128942 61 79615365
Hospitalisation 80.48 14.56 26 128936 94210 79521216
B-cell lymphoma recurrent 80.44 14.56 37 128925 963 79614463
Blood glucose increased 80.06 14.56 43 128919 114932 79500494
Therapy non-responder 79.61 14.56 328 128634 91977 79523449
Leukoencephalopathy 79.31 14.56 80 128882 7849 79607577
Metastasis 79.26 14.56 75 128887 6805 79608621
Impaired healing 78.82 14.56 22 128940 87633 79527793
Cytomegalovirus infection reactivation 78.27 14.56 83 128879 8633 79606793
Myeloid leukaemia 77.96 14.56 33 128929 700 79614726
Epstein-Barr virus associated lymphoproliferative disorder 77.56 14.56 56 128906 3476 79611950
Memory impairment 77.49 14.56 42 128920 111692 79503734
Dry mouth 77.48 14.56 23 128939 87996 79527430
Pneumothorax 77.38 14.56 153 128809 28170 79587256
Alveolar soft part sarcoma 76.52 14.56 20 128942 80 79615346
Oesophageal candidiasis 76.16 14.56 84 128878 9134 79606292
Viraemia 75.90 14.56 51 128911 2818 79612608
Bacterial sepsis 75.28 14.56 79 128883 8119 79607307
Systemic candida 75.15 14.56 72 128890 6634 79608792
Leukaemia recurrent 75.05 14.56 50 128912 2724 79612702
Mucormycosis 74.91 14.56 80 128882 8389 79607037
Stomatitis 74.77 14.56 449 128513 146308 79469118
Blood pressure systolic increased 74.54 14.56 10 128952 66976 79548450
Hyperhidrosis 74.45 14.56 81 128881 151411 79464015
Gene mutation 74.08 14.56 49 128913 2637 79612789
Chest pain 73.97 14.56 223 128739 282081 79333345
Recurrent cancer 73.97 14.56 49 128913 2644 79612782
Ovarian failure 73.79 14.56 31 128931 645 79614781
Palpitations 73.68 14.56 58 128904 126552 79488874
Back pain 73.61 14.56 249 128713 303931 79311495
Graft versus host disease in skin 73.41 14.56 68 128894 6005 79609421
Lymphoma 73.36 14.56 114 128848 17346 79598080
Enterococcal bacteraemia 72.81 14.56 51 128911 3017 79612409
Gastrointestinal toxicity 72.43 14.56 77 128885 8032 79607394
Post transplant lymphoproliferative disorder 72.34 14.56 91 128871 11373 79604053
Vision blurred 71.71 14.56 41 128921 105857 79509569
Nasal congestion 71.13 14.56 18 128944 76534 79538892
Acute lymphocytic leukaemia 70.69 14.56 61 128901 4908 79610518
Cytokine release syndrome 70.44 14.56 170 128792 35828 79579598
Fungaemia 68.66 14.56 58 128904 4533 79610893
Oedema peripheral 68.48 14.56 196 128766 252092 79363334
Dyspnoea 68 14.56 977 127985 856048 78759378
Capillary leak syndrome 67.97 14.56 54 128908 3871 79611555
Herpes simplex 67.94 14.56 91 128871 12096 79603330
Metastases to lung 67.30 14.56 112 128850 18051 79597375
Gastrooesophageal reflux disease 66.90 14.56 43 128919 104203 79511223
Superior vena cava syndrome 66.86 14.56 35 128927 1214 79614212
Hypokalaemia 66.68 14.56 430 128532 143610 79471816
Pulmonary vascular disorder 66.23 14.56 33 128929 1030 79614396
Varicella zoster virus infection 66.20 14.56 56 128906 4385 79611041
Staphylococcal infection 65.94 14.56 226 128736 58069 79557357
Myocardial infarction 65.26 14.56 124 128838 184005 79431421
Acute lymphocytic leukaemia recurrent 65.20 14.56 57 128905 4667 79610759
Complications of bone marrow transplant 65.13 14.56 28 128934 618 79614808
Refractory anaemia with an excess of blasts 65.08 14.56 31 128931 875 79614551
Hypoglycaemia 65.07 14.56 42 128920 101552 79513874
Systemic mycosis 64.86 14.56 45 128917 2621 79612805
Streptococcal bacteraemia 63.28 14.56 50 128912 3556 79611870
Pericarditis 62.89 14.56 46 128916 104190 79511236
Viral haemorrhagic cystitis 62.74 14.56 40 128922 2021 79613405
Depressed mood 62.52 14.56 4 128958 48476 79566950
Hypomagnesaemia 62.20 14.56 192 128770 46719 79568707
Nephrolithiasis 61.63 14.56 7 128955 53284 79562142
Metastases to lymph nodes 61.62 14.56 80 128882 10317 79605109
Coronary artery disease 61.60 14.56 15 128947 65459 79549967
Retinal haemorrhage 61.28 14.56 71 128891 8146 79607280
Heart rate decreased 60.75 14.56 19 128943 70297 79545129
Loss of consciousness 60.48 14.56 112 128850 167831 79447595
Salivary gland cancer 60.12 14.56 24 128938 436 79614990
Klebsiella bacteraemia 59.96 14.56 45 128917 2965 79612461
Hepatosplenic T-cell lymphoma 59.91 14.56 29 128933 849 79614577
Pneumonia fungal 59.90 14.56 82 128880 11128 79604298
Fanconi syndrome 59.80 14.56 44 128918 2812 79612614
Cardiomyopathy 59.68 14.56 139 128823 28635 79586791
Cystitis bacterial 59.41 14.56 27 128935 683 79614743
Drug ineffective 58.31 14.56 2215 126747 1078698 78536728
Pleural effusion 57.34 14.56 417 128545 144845 79470581
Adverse drug reaction 57.25 14.56 18 128944 66374 79549052
Product prescribing error 56.90 14.56 4 128958 44809 79570617
Fusarium infection 56.87 14.56 36 128926 1796 79613630
Angioedema 56.60 14.56 26 128936 76009 79539417
Haematochezia 56.45 14.56 36 128926 87609 79527817
Premature menopause 56.33 14.56 25 128937 597 79614829
Pulmonary arteriopathy 56.02 14.56 16 128946 95 79615331
Injection site pruritus 56.02 14.56 3 128959 42280 79573146
Cardiac failure congestive 55.81 14.56 90 128872 142312 79473114
Clostridium colitis 55.57 14.56 42 128920 2797 79612629
Folliculitis 55.52 14.56 11 128951 55369 79560057
Rhabdomyolysis 55.41 14.56 51 128911 103080 79512346
Balance disorder 55.38 14.56 47 128915 98810 79516616
Lower respiratory tract infection 55.16 14.56 77 128885 129143 79486283
Road traffic accident 55.15 14.56 4 128958 43660 79571766
Norovirus test positive 54.84 14.56 25 128937 637 79614789
Electrocardiogram QT prolonged 54.38 14.56 40 128922 90346 79525080
Aortic thrombosis 54.36 14.56 34 128928 1661 79613765
Myelopathy 54.31 14.56 51 128911 4582 79610844
Skin toxicity 54.06 14.56 67 128895 8247 79607179
Device related infection 53.75 14.56 149 128813 34145 79581281
Hypoaesthesia 53.44 14.56 133 128829 179219 79436207
Blood stem cell transplant failure 53.31 14.56 23 128939 512 79614914
Disseminated aspergillosis 53.29 14.56 29 128933 1089 79614337
Paraneoplastic neurological syndrome 53.17 14.56 14 128948 58 79615368
Paraesthesia 53.13 14.56 130 128832 176193 79439233
Small cell lung cancer 52.84 14.56 41 128921 2839 79612587
Osteonecrosis 52.64 14.56 139 128823 30956 79584470
Ameloblastoma 52.53 14.56 15 128947 89 79615337
Pneumonia klebsiella 52.40 14.56 52 128910 5002 79610424
Vertigo 52.40 14.56 23 128939 69059 79546367
Burning sensation 52.19 14.56 15 128947 58617 79556809
Renal failure 51.93 14.56 525 128437 200443 79414983
Refractory cancer 51.75 14.56 18 128944 218 79615208
T-cell type acute leukaemia 51.45 14.56 17 128945 174 79615252
Escherichia bacteraemia 51.13 14.56 58 128904 6504 79608922
Hyperkalaemia 51.03 14.56 66 128896 114332 79501094
Deafness 50.80 14.56 108 128854 20929 79594497
Sedation 50.59 14.56 11 128951 51884 79563542
Pseudomonas infection 50.12 14.56 107 128855 20796 79594630
Medulloblastoma recurrent 49.92 14.56 15 128947 109 79615317
Pulmonary alveolar haemorrhage 49.81 14.56 76 128886 11381 79604045
Cardiomyopathy acute 49.81 14.56 19 128943 304 79615122
Rash pruritic 49.55 14.56 27 128935 71602 79543824
Wrong technique in product usage process 49.44 14.56 29 128933 73846 79541580
Lactic acidosis 49.43 14.56 26 128936 70333 79545093
Radiation pneumonitis 49.41 14.56 45 128917 3888 79611538
Metastases to spleen 49.23 14.56 23 128939 621 79614805
Stenotrophomonas infection 49.04 14.56 44 128918 3729 79611697
Embolism 48.86 14.56 84 128878 13898 79601528
Exposure during pregnancy 48.66 14.56 55 128907 101077 79514349
Nervous system disorder 48.50 14.56 123 128839 26733 79588693
Type 2 diabetes mellitus 48.35 14.56 16 128946 57106 79558320
Hepatosplenomegaly 47.90 14.56 54 128908 6015 79609411
Radiation oesophagitis 47.68 14.56 23 128939 668 79614758
Trichosporon infection 47.64 14.56 26 128936 982 79614444
Large intestinal ulcer perforation 47.55 14.56 13 128949 64 79615362
Delayed puberty 47.39 14.56 16 128946 176 79615250
Gastrointestinal fungal infection 47.34 14.56 21 128941 501 79614925
Aggression 47.31 14.56 12 128950 50946 79564480
Diaphragm muscle weakness 47.30 14.56 16 128946 177 79615249
Cerebrovascular accident 46.39 14.56 115 128847 155177 79460249
Ejection fraction decreased 46.28 14.56 142 128820 34435 79580991
Amnesia 46.26 14.56 22 128940 63035 79552391
Swollen tongue 45.86 14.56 7 128955 42563 79572863
Heart rate increased 45.72 14.56 78 128884 120646 79494780
Musculoskeletal pain 45.71 14.56 59 128903 102295 79513131
Hallucination 45.35 14.56 43 128919 85702 79529724
Dyspepsia 45.17 14.56 66 128896 108621 79506805
Hyperbilirubinaemia 45.02 14.56 113 128849 24405 79591021
Rhabdomyosarcoma recurrent 44.89 14.56 14 128948 117 79615309
Hypertension 44.38 14.56 333 128629 330659 79284767
Pseudomonal bacteraemia 44.18 14.56 38 128924 3044 79612382
JC virus infection 44.12 14.56 42 128920 3839 79611587
Metastases to bone marrow 43.90 14.56 23 128939 799 79614627
Leukaemia 43.86 14.56 51 128911 5874 79609552
Abscess bacterial 43.59 14.56 23 128939 811 79614615
Confusional state 43.56 14.56 318 128644 317679 79297747
Skin candida 43.36 14.56 32 128930 2055 79613371
Drug ineffective for unapproved indication 43.32 14.56 181 128781 51057 79564369
Maternal exposure during pregnancy 43.26 14.56 98 128864 136440 79478986
Hypoalbuminaemia 43.20 14.56 102 128860 21195 79594231
Medication error 43.11 14.56 29 128933 68613 79546813
Serotonin syndrome 42.98 14.56 10 128952 45017 79570409
Mesenteric abscess 42.75 14.56 14 128948 139 79615287
Influenza 42.73 14.56 91 128871 129515 79485911
Hepatotoxicity 42.32 14.56 180 128782 51172 79564254
Red blood cell sedimentation rate increased 42.30 14.56 11 128951 45931 79569495
Nail pigmentation 42.28 14.56 17 128945 315 79615111
Staphylococcal sepsis 41.98 14.56 81 128881 14645 79600781
Fluid retention 41.85 14.56 31 128931 69778 79545648
Subdural hygroma 41.47 14.56 19 128943 490 79614936
Metastases to liver 41.42 14.56 120 128842 28194 79587232
Surgery 41.38 14.56 3 128959 32763 79582663
Blood culture positive 41.08 14.56 59 128903 8370 79607056
Drug dependence 41.07 14.56 8 128954 40761 79574665
Plasma cell leukaemia 40.78 14.56 29 128933 1757 79613669
Toxic encephalopathy 40.34 14.56 69 128893 11371 79604055
Respiratory distress 40.24 14.56 194 128768 58145 79557281
Gastroenteritis adenovirus 40.01 14.56 17 128945 364 79615062
Fungal oesophagitis 39.94 14.56 23 128939 965 79614461
International normalised ratio increased 39.76 14.56 47 128915 84674 79530752
Eosinophilia 39.63 14.56 12 128950 45333 79570093
Hypertransaminasaemia 39.54 14.56 70 128892 11854 79603572
Encephalitis 39.43 14.56 79 128883 14681 79600745
Chronic obstructive pulmonary disease 39.43 14.56 48 128914 85371 79530055
Graft versus host disease in gastrointestinal tract 39.38 14.56 50 128912 6306 79609120
Acquired gene mutation 39.26 14.56 31 128931 2202 79613224
Encephalitis cytomegalovirus 39.24 14.56 24 128938 1126 79614300
Drug reaction with eosinophilia and systemic symptoms 39.20 14.56 28 128934 64216 79551210
Ear infection 38.64 14.56 5 128957 34427 79580999
Pneumonia 38.59 14.56 1366 127596 658880 78956546
Adverse event 38.41 14.56 25 128937 60189 79555237
Diabetes mellitus 38.40 14.56 42 128920 78348 79537078
Flagellate dermatitis 38.33 14.56 15 128947 258 79615168
Bicytopenia 37.62 14.56 42 128920 4628 79610798
Traumatic lung injury 37.40 14.56 31 128931 2360 79613066
Myelitis 37.40 14.56 31 128931 2360 79613066
Encephalitis viral 37.38 14.56 32 128930 2547 79612879
Accidental overdose 37.37 14.56 9 128953 39572 79575854
Lung infiltration 37.35 14.56 101 128861 22811 79592615
Hepatic cirrhosis 37.01 14.56 6 128956 34900 79580526
Abdominal distension 37.00 14.56 87 128875 119563 79495863
Unevaluable event 36.94 14.56 22 128940 55563 79559863
Gait inability 36.85 14.56 25 128937 58892 79556534
Osteonecrosis of jaw 36.77 14.56 12 128950 43214 79572212
Underdose 36.76 14.56 5 128957 33146 79582280
Chronic myeloid leukaemia 36.70 14.56 37 128925 3627 79611799
Graft versus host disease in liver 36.68 14.56 27 128935 1727 79613699
Therapy cessation 36.54 14.56 8 128954 37554 79577872
Therapy interrupted 36.54 14.56 4 128958 31337 79584089
Rhinovirus infection 36.34 14.56 54 128908 7899 79607527
Neck pain 36.29 14.56 41 128921 75376 79540050
Escherichia infection 36.23 14.56 86 128876 17931 79597495
Femur fracture 36.08 14.56 9 128953 38643 79576783
Neuroblastoma 36.03 14.56 14 128948 236 79615190
Peripheral T-cell lymphoma unspecified 35.98 14.56 19 128943 671 79614755
Injection site reaction 35.97 14.56 22 128940 54763 79560663
Ganglioneuroblastoma 35.94 14.56 9 128953 29 79615397
Faeces discoloured 35.85 14.56 3 128959 29124 79586302
Acute myelomonocytic leukaemia 35.84 14.56 15 128947 309 79615117
Nasal abscess 35.79 14.56 13 128949 180 79615246
Peripheral motor neuropathy 35.57 14.56 35 128927 3332 79612094
Metastases to meninges 35.41 14.56 36 128926 3565 79611861
Mantle cell lymphoma recurrent 35.40 14.56 18 128944 587 79614839
Disturbance in attention 35.35 14.56 19 128943 50782 79564644
Electrolyte imbalance 35.16 14.56 120 128842 30761 79584665
Venous thrombosis 34.96 14.56 50 128912 7066 79608360
Hepatic failure 34.88 14.56 193 128769 61019 79554407
Epstein-Barr virus infection reactivation 34.86 14.56 27 128935 1865 79613561
Focal nodular hyperplasia 34.68 14.56 19 128943 723 79614703
Joint range of motion decreased 34.67 14.56 6 128956 33276 79582150
Extravasation 34.19 14.56 36 128926 3714 79611712
Lower respiratory tract infection fungal 34.11 14.56 20 128942 868 79614558
Blood creatine phosphokinase increased 33.96 14.56 34 128928 66056 79549370
Injection site haemorrhage 33.95 14.56 3 128959 27867 79587559
Frequent bowel movements 33.86 14.56 4 128958 29535 79585891
Adrenocortical carcinoma 33.73 14.56 10 128952 69 79615357
Diffuse alveolar damage 33.57 14.56 35 128927 3569 79611857
Eczema 33.56 14.56 12 128950 40806 79574620
Streptococcal infection 33.45 14.56 55 128907 8775 79606651
Necrotising gastritis 33.13 14.56 10 128952 74 79615352
Acne 32.92 14.56 3 128959 27187 79588239
Hepatic candidiasis 32.89 14.56 10 128952 76 79615350
Dry skin 32.68 14.56 37 128925 67958 79547468
Epstein Barr virus positive mucocutaneous ulcer 32.59 14.56 19 128943 816 79614610
Retinopathy proliferative 32.50 14.56 11 128951 122 79615304
Blood pressure diastolic decreased 32.47 14.56 5 128957 30211 79585215
Sciatica 32.47 14.56 7 128955 33215 79582211
Vena cava thrombosis 32.28 14.56 31 128931 2864 79612562
Drug clearance decreased 32.24 14.56 33 128929 3294 79612132
Enterocolitis 32.19 14.56 72 128890 14440 79600986
Sopor 32.17 14.56 7 128955 33003 79582423
Throat irritation 32.07 14.56 13 128949 40933 79574493
Neurological decompensation 32.04 14.56 41 128921 5212 79610214
Bone marrow transplant 31.89 14.56 23 128939 1425 79614001
Accidental exposure to product 31.86 14.56 6 128956 31316 79584110
T-cell lymphoma 31.71 14.56 22 128940 1281 79614145
Cutaneous calcification 31.64 14.56 11 128951 133 79615293
Infusion related reaction 31.62 14.56 230 128732 230007 79385419
Alpha haemolytic streptococcal infection 31.62 14.56 28 128934 2332 79613094
Flatulence 31.19 14.56 15 128947 42709 79572717
Choriocarcinoma 31.02 14.56 9 128953 57 79615369
T-cell lymphoma refractory 31.02 14.56 9 128953 57 79615369
Encephalitis enteroviral 30.99 14.56 11 128951 142 79615284
Alopecia 30.87 14.56 233 128729 231122 79384304
Cerebellar tumour 30.83 14.56 10 128952 96 79615330
Transient ischaemic attack 30.82 14.56 24 128938 52671 79562755
Head injury 30.70 14.56 11 128951 37358 79578068
Tooth malformation 30.64 14.56 11 128951 147 79615279
Intestinal perforation 30.62 14.56 79 128883 17347 79598079
Toxicity to various agents 30.39 14.56 489 128473 421051 79194375
Central nervous system lymphoma 30.35 14.56 27 128935 2262 79613164
Fanconi syndrome acquired 30.33 14.56 29 128933 2665 79612761
Treatment noncompliance 30.33 14.56 24 128938 52244 79563182
Device issue 30.27 14.56 4 128958 27104 79588322
Azoospermia 30.18 14.56 11 128951 154 79615272
Blood electrolytes abnormal 30.09 14.56 25 128937 1909 79613517
Pregnancy 29.89 14.56 4 128958 26847 79588579
Hypothyroidism 29.73 14.56 165 128797 52227 79563199
Retinopathy 29.65 14.56 34 128928 3857 79611569
Escherichia sepsis 29.58 14.56 51 128911 8457 79606969
Recall phenomenon 29.57 14.56 20 128942 1117 79614309
Plasmacytoma 29.46 14.56 36 128926 4367 79611059
Chest discomfort 29.42 14.56 119 128843 137925 79477501
Diverticulitis 29.39 14.56 19 128943 45917 79569509
Localised infection 29.31 14.56 12 128950 37563 79577863
Prescribed underdose 29.29 14.56 6 128956 29508 79585918
Abortion spontaneous 29.28 14.56 6 128956 29501 79585925
Pneumonia adenoviral 29.28 14.56 15 128947 497 79614929
Upper respiratory tract infection 29.23 14.56 65 128897 91103 79524323
Hip fracture 29.03 14.56 7 128955 30754 79584672
Rhinorrhoea 28.94 14.56 49 128913 76025 79539401
Neutrophil count abnormal 28.90 14.56 32 128930 3494 79611932
Immune effector cell-associated neurotoxicity syndrome 28.60 14.56 41 128921 5807 79609619
Brain sarcoma 28.58 14.56 7 128955 20 79615406
Acute monocytic leukaemia 28.55 14.56 15 128947 524 79614902
Metastases to diaphragm 28.53 14.56 8 128954 44 79615382
Splenomegaly 28.49 14.56 86 128876 20668 79594758
Cerebral salt-wasting syndrome 28.39 14.56 10 128952 126 79615300
Enterococcal sepsis 28.17 14.56 28 128934 2698 79612728
Respiratory arrest 28.00 14.56 31 128931 57519 79557907
Metastases to muscle 27.96 14.56 13 128949 347 79615079
Central nervous system fungal infection 27.83 14.56 14 128948 446 79614980
Cellulitis gangrenous 27.66 14.56 12 128950 271 79615155
Cerebellar haemangioma 27.60 14.56 9 128953 88 79615338
Cataract 27.53 14.56 36 128926 62084 79553342
Peripheral artery thrombosis 27.50 14.56 31 128931 3452 79611974
Retinal pigment epitheliopathy 27.44 14.56 14 128948 460 79614966
Geotrichum infection 27.31 14.56 18 128944 963 79614463
Odynophagia 27.17 14.56 58 128904 11269 79604157
Fungal sepsis 27.12 14.56 23 128939 1807 79613619
Neoplasm 27.04 14.56 51 128911 9065 79606361
Adenovirus reactivation 27.00 14.56 13 128949 376 79615050
Renal impairment 26.97 14.56 381 128581 157402 79458024
Infection 26.78 14.56 544 128418 241168 79374258
Gliosis 26.78 14.56 14 128948 484 79614942
Arterial thrombosis 26.78 14.56 27 128935 2647 79612779
Blood glucose decreased 26.74 14.56 5 128957 26229 79589197
Dyskinesia 26.69 14.56 20 128942 44753 79570673
Iris atrophy 26.68 14.56 10 128952 152 79615274
Leukoerythroblastosis 26.53 14.56 12 128950 300 79615126
Metastases to retroperitoneum 26.53 14.56 13 128949 391 79615035
Osteoporosis 26.49 14.56 29 128933 54083 79561343
Li-Fraumeni syndrome 26.34 14.56 6 128956 11 79615415
Strongyloidiasis 26.29 14.56 32 128930 3866 79611560
Cardiac disorder 26.28 14.56 41 128921 65716 79549710
Abnormal behaviour 26.27 14.56 13 128949 36408 79579018
Cerebral venous thrombosis 26.12 14.56 27 128935 2726 79612700
Viral infection 26.11 14.56 138 128824 42878 79572548
Cardio-respiratory arrest 26.09 14.56 89 128873 108421 79507005
Listeria sepsis 26.06 14.56 16 128946 756 79614670
Cholelithiasis 26.03 14.56 28 128934 52636 79562790
Basal cell naevus syndrome 26.03 14.56 7 128955 32 79615394
Breast cancer 26.01 14.56 11 128951 33770 79581656
Intestinal atresia 25.96 14.56 8 128954 64 79615362
Respiratory syncytial virus infection 25.93 14.56 51 128911 9351 79606075
Myelitis transverse 25.89 14.56 23 128939 1924 79613502
Peripheral sensorimotor neuropathy 25.86 14.56 28 128934 2982 79612444
Pericardial effusion 25.82 14.56 145 128817 46092 79569334
Adenoviral hepatitis 25.78 14.56 17 128945 910 79614516
Sinus polyp 25.77 14.56 14 128948 524 79614902
Bradycardia 25.76 14.56 122 128840 135435 79479991
Papillary thyroid cancer 25.69 14.56 26 128936 2560 79612866
Genotoxicity 25.68 14.56 7 128955 34 79615392
Multiple sclerosis 25.58 14.56 3 128959 22279 79593147
Blood fibrinogen decreased 25.56 14.56 23 128939 1956 79613470
CNS ventriculitis 25.54 14.56 13 128949 425 79615001
Dry eye 25.42 14.56 14 128948 36917 79578509
Granulocyte count decreased 25.32 14.56 22 128940 1786 79613640
Agitation 25.21 14.56 80 128882 99635 79515791
Hot flush 25.15 14.56 31 128931 54846 79560580
Therapy responder 25.12 14.56 13 128949 440 79614986
Hypodontia 25.08 14.56 6 128956 15 79615411
Pulmonary veno-occlusive disease 25.02 14.56 21 128941 1627 79613799
Autoimmune haemolytic anaemia 25.01 14.56 47 128915 8333 79607093
Grip strength decreased 24.97 14.56 3 128959 21866 79593560
Emotional distress 24.94 14.56 17 128945 39952 79575474
Streptococcal sepsis 24.90 14.56 27 128935 2880 79612546
Dysstasia 24.87 14.56 7 128955 27739 79587687
Dyspnoea exertional 24.82 14.56 66 128896 87007 79528419
Disorder of orbit 24.76 14.56 9 128953 125 79615301
Hair follicle tumour benign 24.67 14.56 13 128949 457 79614969
Ewing's sarcoma recurrent 24.54 14.56 6 128956 17 79615409
Procedural pain 24.40 14.56 4 128958 23080 79592346
Tumour hyperprogression 24.35 14.56 10 128952 196 79615230
Carbamoyl phosphate synthetase deficiency 24.28 14.56 6 128956 18 79615408
Tumour necrosis 24.16 14.56 22 128940 1900 79613526
Chromaturia 24.02 14.56 6 128956 25740 79589686
Enterobacter bacteraemia 23.94 14.56 16 128946 876 79614550
Neuroblastoma recurrent 23.94 14.56 10 128952 205 79615221
Respiratory tract infection fungal 23.86 14.56 18 128944 1195 79614231
Clostridial infection 23.57 14.56 37 128925 5677 79609749
Coronavirus infection 23.57 14.56 43 128919 7454 79607972
Post-acute COVID-19 syndrome 23.56 14.56 13 128949 502 79614924
Osteosarcoma metastatic 23.52 14.56 7 128955 49 79615377
Hypoxia 23.50 14.56 263 128699 102980 79512446
Sleep apnoea syndrome 23.46 14.56 15 128947 36463 79578963
Diabetic ketoacidosis 23.40 14.56 13 128949 34109 79581317
Carcinoid crisis 23.37 14.56 13 128949 510 79614916
B-cell lymphoma refractory 23.37 14.56 9 128953 148 79615278
Ascites 23.29 14.56 205 128757 75357 79540069
Liver function test abnormal 23.20 14.56 43 128919 64432 79550994
Serum ferritin increased 23.14 14.56 50 128912 9797 79605629
Human polyomavirus infection 23.07 14.56 17 128945 1089 79614337
Heart rate irregular 23.06 14.56 12 128950 32667 79582759
Platelet disorder 23.01 14.56 26 128936 2903 79612523
Full blood count abnormal 22.96 14.56 19 128943 40455 79574971
Hepatic infection fungal 22.96 14.56 10 128952 228 79615198
Small cell carcinoma 22.88 14.56 11 128951 317 79615109
Amenorrhoea 22.78 14.56 43 128919 7649 79607777
Transdifferentiation of neoplasm 22.77 14.56 8 128954 100 79615326
Depressed level of consciousness 22.75 14.56 80 128882 96572 79518854
Candida sepsis 22.69 14.56 24 128938 2489 79612937
Acute lymphocytic leukaemia refractory 22.67 14.56 9 128953 161 79615265
Product substitution issue 22.59 14.56 3 128959 20253 79595173
Large intestine perforation 22.54 14.56 63 128899 14504 79600922
Sputum discoloured 22.47 14.56 4 128958 21739 79593687
Myeloproliferative neoplasm 22.45 14.56 16 128946 973 79614453
Basal ganglion degeneration 22.41 14.56 12 128950 436 79614990
Pain in jaw 22.30 14.56 25 128937 46126 79569300
Feeling hot 22.24 14.56 39 128923 59695 79555731
Paraparesis 22.13 14.56 29 128933 3774 79611652
Hepatomegaly 22.06 14.56 74 128888 18800 79596626
Iron deficiency anaemia 22.06 14.56 7 128955 25665 79589761
Metastases to bone 22.00 14.56 88 128874 24339 79591087
Withdrawal syndrome 21.90 14.56 8 128954 26846 79588580
Visual impairment 21.85 14.56 76 128886 92055 79523371
Hydrocephalus 21.84 14.56 46 128916 8854 79606572
Hepatic function abnormal 21.84 14.56 197 128765 72910 79542516
Blood urine present 21.83 14.56 4 128958 21293 79594133
Sneezing 21.75 14.56 3 128959 19680 79595746
Arteriosclerotic retinopathy 21.71 14.56 6 128956 31 79615395
Primitive neuroectodermal tumour 21.71 14.56 6 128956 31 79615395
Hypertensive hydrocephalus 21.67 14.56 5 128957 10 79615416
Guillain-Barre syndrome 21.62 14.56 46 128916 8919 79606507
Human herpesvirus 8 infection 21.59 14.56 17 128945 1203 79614223
Inappropriate antidiuretic hormone secretion 21.50 14.56 92 128870 26221 79589205
Skin laceration 21.40 14.56 10 128952 28952 79586474
Testicular malignant teratoma 21.35 14.56 5 128957 11 79615415
Terminal ileitis 21.19 14.56 15 128947 902 79614524
Tooth disorder 21.08 14.56 8 128954 26225 79589201
Meningitis bacterial 21.04 14.56 24 128938 2708 79612718
Hyperlipidaemia 20.90 14.56 8 128954 26085 79589341
Clostridium bacteraemia 20.87 14.56 11 128951 387 79615039
Mucosal infection 20.76 14.56 12 128950 507 79614919
Scedosporium infection 20.73 14.56 18 128944 1460 79613966
Primary mediastinal large B-cell lymphoma recurrent 20.73 14.56 7 128955 77 79615349
Clostridial sepsis 20.72 14.56 15 128947 935 79614491
Hiatus hernia 20.68 14.56 6 128956 23306 79592120
Mucocutaneous ulceration 20.64 14.56 11 128951 396 79615030
Hypophosphataemia 20.62 14.56 75 128887 19838 79595588
Hypoacusis 20.60 14.56 100 128862 30050 79585376
Nightmare 20.60 14.56 8 128954 25853 79589573
Haematopoietic stem cell mobilisation 20.59 14.56 9 128953 207 79615219
Kidney infection 20.56 14.56 5 128957 21846 79593580
Obesity 20.54 14.56 16 128946 35109 79580317
Cerebral toxoplasmosis 20.34 14.56 22 128940 2340 79613086
Toxic neuropathy 20.30 14.56 15 128947 965 79614461
Synovial sarcoma 20.18 14.56 7 128955 84 79615342
Diabetes mellitus inadequate control 20.18 14.56 7 128955 24257 79591169
Polyneuropathy 20.16 14.56 85 128877 24066 79591360
Ileus 20.16 14.56 90 128872 26121 79589305
Flushing 20.16 14.56 225 128737 88043 79527383
Speech disorder developmental 20.14 14.56 13 128949 671 79614755
Colitis ulcerative 20.09 14.56 16 128946 34726 79580700
Premature ageing 20.03 14.56 7 128955 86 79615340
Medulloblastoma 20.03 14.56 7 128955 86 79615340
Musculoskeletal disorder 20.01 14.56 5 128957 21443 79593983
Delirium 19.94 14.56 70 128892 84557 79530869
Adenocarcinoma gastric 19.91 14.56 19 128943 1742 79613684
Pneumomediastinum 19.86 14.56 27 128935 3640 79611786
Gastrointestinal disorder 19.85 14.56 116 128846 122089 79493337
Musculoskeletal discomfort 19.75 14.56 4 128958 19831 79595595
Engraft failure 19.65 14.56 13 128949 700 79614726
Meningitis tuberculous 19.64 14.56 16 128946 1189 79614237
Chronic myelomonocytic leukaemia 19.63 14.56 14 128948 852 79614574
Body temperature decreased 19.62 14.56 14 128948 32131 79583295
Arteriosclerosis 19.62 14.56 3 128959 18224 79597202
Lacrimation increased 19.55 14.56 6 128956 22471 79592955
Limbic encephalitis 19.50 14.56 14 128948 861 79614565
Schistocytosis 19.36 14.56 6 128956 49 79615377
Gallbladder empyema 19.27 14.56 7 128955 97 79615329
Metastatic lymphoma 19.18 14.56 10 128952 344 79615082
Mucosal toxicity 19.15 14.56 12 128950 588 79614838
Autoimmune neutropenia 19.13 14.56 12 128950 589 79614837
Hyperadrenocorticism 19.10 14.56 10 128952 347 79615079
Hypertensive crisis 19.07 14.56 5 128957 20765 79594661
Small intestinal perforation 18.96 14.56 25 128937 3272 79612154
Hypovolaemic shock 18.90 14.56 53 128909 12223 79603203
Pneumonia cytomegaloviral 18.89 14.56 31 128931 4938 79610488
Eosinophilic cystitis 18.89 14.56 7 128955 103 79615323
Platelet transfusion 18.76 14.56 21 128941 2321 79613105
Plasma cell myeloma recurrent 18.74 14.56 31 128931 4970 79610456
Drug clearance increased 18.67 14.56 9 128953 261 79615165
Papilloedema 18.65 14.56 35 128927 6198 79609228
Fracture 18.63 14.56 6 128956 21795 79593631
Atypical teratoid/rhabdoid tumour of CNS 18.57 14.56 5 128957 23 79615403
Renal cell carcinoma 18.53 14.56 36 128926 6542 79608884
Epiphyses premature fusion 18.52 14.56 7 128955 109 79615317
Neuroendocrine tumour of the lung metastatic 18.52 14.56 7 128955 109 79615317
Acanthamoeba infection 18.42 14.56 11 128951 494 79614932
Ewing's sarcoma 18.39 14.56 5 128957 24 79615402
Minimal residual disease 18.38 14.56 11 128951 496 79614930
Testicular germ cell cancer metastatic 18.37 14.56 6 128956 59 79615367
Fusobacterium infection 18.35 14.56 7 128955 112 79615314
Pneumocystis jirovecii infection 18.30 14.56 23 128939 2871 79612555
Clostridium difficile infection 18.26 14.56 125 128837 42560 79572866
Blood stem cell harvest failure 18.24 14.56 7 128955 114 79615312
Immune-mediated enterocolitis 18.18 14.56 30 128932 4800 79610626
Pneumonia aspiration 18.16 14.56 52 128910 66915 79548511
Cold sweat 18.15 14.56 4 128958 18695 79596731
Spinal column injury 18.11 14.56 20 128942 2178 79613248
Epstein-Barr viraemia 18.05 14.56 20 128942 2185 79613241
Ocular vascular disorder 18.05 14.56 11 128951 513 79614913
Inflammatory pseudotumour 18.02 14.56 6 128956 63 79615363
Bacterial tracheitis 18.02 14.56 6 128956 63 79615363
Blindness cortical 18.00 14.56 14 128948 973 79614453
Intracardiac thrombus 17.99 14.56 28 128934 4265 79611161
Opportunistic infection 17.95 14.56 23 128939 2927 79612499
Product intolerance 17.75 14.56 5 128957 28 79615398
Photosensitivity reaction 17.73 14.56 6 128956 21121 79594305
Peritoneal gliomatosis 17.68 14.56 4 128958 7 79615419
Radiation injury 17.68 14.56 13 128949 830 79614596
Lymphocyte count decreased 17.65 14.56 134 128828 47155 79568271
Product administered to patient of inappropriate age 17.65 14.56 32 128930 5521 79609905
Left ventricular dysfunction 17.63 14.56 70 128892 19291 79596135
Psychomotor hyperactivity 17.63 14.56 3 128959 16846 79598580
Vulvovaginal inflammation 17.63 14.56 11 128951 535 79614891
Vulvovaginitis 17.63 14.56 9 128953 296 79615130
Abdominal compartment syndrome 17.62 14.56 17 128945 1580 79613846
Muscle twitching 17.62 14.56 9 128953 24755 79590671
Stomatitis necrotising 17.62 14.56 8 128954 202 79615224
Tissue infiltration 17.60 14.56 12 128950 679 79614747
Ocular hyperaemia 17.60 14.56 12 128950 28194 79587232
Mania 17.54 14.56 4 128958 18256 79597170
Viral hepatitis carrier 17.46 14.56 5 128957 30 79615396
Atypical haemolytic uraemic syndrome 17.45 14.56 14 128948 1018 79614408
Retinal toxicity 17.44 14.56 16 128946 1395 79614031
Glioblastoma multiforme 17.32 14.56 15 128947 1213 79614213
Angina pectoris 17.31 14.56 36 128926 51696 79563730
Subdural haemorrhage 17.30 14.56 33 128929 5915 79609511
Acute kidney injury 17.02 14.56 1014 127948 518390 79097036
Cerebral fungal infection 16.99 14.56 10 128952 437 79614989
Skin discolouration 16.96 14.56 25 128937 41009 79574417
Lymphoma transformation 16.96 14.56 9 128953 321 79615105
Crying 16.96 14.56 8 128954 23035 79592391
Ventricular tachycardia 16.90 14.56 26 128936 41909 79573517
Follicular thyroid cancer 16.86 14.56 6 128956 78 79615348
Uterine enlargement 16.82 14.56 13 128949 895 79614531
Pharyngeal oedema 16.80 14.56 3 128959 16269 79599157
Spindle cell sarcoma 16.79 14.56 8 128954 226 79615200
Bone marrow infiltration 16.77 14.56 12 128950 734 79614692
Rectal haemorrhage 16.74 14.56 65 128897 76235 79539191
Ganglioneuroma 16.73 14.56 7 128955 144 79615282
Hepatorenal failure 16.73 14.56 15 128947 1270 79614156
Administration related reaction 16.56 14.56 8 128954 233 79615193
Food protein-induced enterocolitis syndrome 16.56 14.56 5 128957 37 79615389
Ill-defined disorder 16.54 14.56 53 128909 65822 79549604
Extrapyramidal disorder 16.50 14.56 8 128954 22671 79592755
Hemianopia 16.49 14.56 17 128945 1711 79613715
Renal infarct 16.41 14.56 21 128941 2670 79612756
Blastic plasmacytoid dendritic cell neoplasia 16.40 14.56 6 128956 85 79615341
Renal tubular dysfunction 16.34 14.56 12 128950 765 79614661
Granulocytopenia 16.29 14.56 48 128914 11383 79604043
Adenomatous polyposis coli 16.29 14.56 8 128954 242 79615184
Pyomyositis 16.27 14.56 11 128951 614 79614812
Mental disorder 16.20 14.56 16 128946 31286 79584140
Chromosome analysis abnormal 16.19 14.56 8 128954 245 79615181
Hypocalcaemia 16.19 14.56 137 128825 49787 79565639
Retinal ischaemia 16.18 14.56 12 128950 776 79614650
Prostate cancer 16.10 14.56 18 128944 33250 79582176
Mood swings 16.08 14.56 6 128956 19874 79595552
Liver injury 16.07 14.56 43 128919 56571 79558855
Swelling face 16.06 14.56 60 128902 71152 79544274
Cardiac dysfunction 16.05 14.56 26 128936 4098 79611328
Subcutaneous emphysema 15.96 14.56 17 128945 1777 79613649
Haemodynamic instability 15.96 14.56 63 128899 17319 79598107
Intussusception 15.91 14.56 14 128948 1156 79614270
Gastrointestinal injury 15.91 14.56 13 128949 970 79614456
Blood pressure decreased 15.84 14.56 95 128867 99371 79516055
Impaired work ability 15.82 14.56 6 128956 19675 79595751
Aspiration bone marrow abnormal 15.82 14.56 7 128955 166 79615260
Hydronephrosis 15.81 14.56 63 128899 17391 79598035
Bone sarcoma 15.79 14.56 6 128956 95 79615331
Transformation to acute myeloid leukaemia 15.75 14.56 13 128949 984 79614442
Product quality issue 15.74 14.56 19 128943 33921 79581505
Deep vein thrombosis 15.73 14.56 279 128683 120640 79494786
Autologous bone marrow transplantation therapy 15.72 14.56 4 128958 14 79615412
Cognitive disorder 15.71 14.56 59 128903 69867 79545559
Joint dislocation 15.70 14.56 4 128958 16935 79598491
Appendicitis 15.69 14.56 71 128891 20723 79594703
Oedema 15.67 14.56 121 128841 119459 79495967
Product administration error 15.66 14.56 17 128945 31829 79583597
Peripheral T-cell lymphoma unspecified recurrent 15.61 14.56 5 128957 46 79615380
Plasma cell myeloma refractory 15.55 14.56 11 128951 661 79614765
Colony stimulating factor therapy 15.53 14.56 10 128952 514 79614912
Skin exfoliation 15.53 14.56 42 128920 55058 79560368
Coronary artery thrombosis 15.52 14.56 22 128940 3084 79612342
Urinary bladder haematoma 15.51 14.56 4 128958 15 79615411
Splenic infarction 15.50 14.56 24 128938 3640 79611786
Paranoia 15.49 14.56 6 128956 19426 79596000
Scrotal abscess 15.39 14.56 10 128952 522 79614904
Spinal fracture 15.38 14.56 5 128957 18049 79597377
Mucosal ulceration 15.35 14.56 17 128945 1856 79613570
Noctiphobia 15.30 14.56 4 128958 16 79615410
Injection site rash 15.24 14.56 5 128957 17949 79597477
Paraesthesia oral 15.23 14.56 7 128955 20464 79594962
Metastases to breast 15.19 14.56 8 128954 281 79615145
B-cell lymphoma 15.11 14.56 32 128930 6183 79609243
Stevens-Johnson syndrome 15.10 14.56 25 128937 39141 79576285
Central nervous system necrosis 15.09 14.56 8 128954 285 79615141
Infection reactivation 15.06 14.56 20 128942 2637 79612789
Tonsillar haemorrhage 14.96 14.56 8 128954 290 79615136
Splenic infection fungal 14.93 14.56 6 128956 111 79615315
Amoebic colitis 14.93 14.56 6 128956 111 79615315
Neutropenic infection 14.89 14.56 19 128943 2408 79613018
Small intestinal obstruction 14.88 14.56 85 128877 27187 79588239
B precursor type acute leukaemia 14.78 14.56 9 128953 419 79615007
Liver function test increased 14.78 14.56 26 128936 39747 79575679
Cerebral artery occlusion 14.76 14.56 16 128946 1706 79613720
Growth hormone deficiency 14.72 14.56 9 128953 422 79615004
Dementia 14.71 14.56 11 128951 24648 79590778
Listeria encephalitis 14.69 14.56 8 128954 301 79615125
Toothache 14.60 14.56 7 128955 19963 79595463

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Podophyllotoxin derivatives
FDA MoA N0000000176 Topoisomerase Inhibitors
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:59517 DNA synthesis inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
FDA EPC N0000175609 Topoisomerase Inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Small cell carcinoma of lung indication 254632001 DOID:5409
Malignant tumor of testis indication 363449006 DOID:2998
Treatment prior to tumor-specific T-cell infusion therapy indication
Allogeneic bone marrow transplantation off-label use 58390007
Ewing's sarcoma off-label use 76909002 DOID:3369
Acute myeloid leukemia, disease off-label use 91861009
Kaposi's sarcoma off-label use 109385007
Diffuse non-Hodgkin's lymphoma, large cell off-label use 109969005
Multiple myeloma off-label use 109989006 DOID:9538
Hodgkin's disease off-label use 118599009
Burkitt's lymphoma off-label use 118617000
Non-small cell lung cancer off-label use 254637007 DOID:3908
Osteosarcoma of bone off-label use 307576001 DOID:3376
Malignant tumor of ovary off-label use 363443007 DOID:2394
Neuroblastoma off-label use 432328008 DOID:769
Ovarian Germ Cell Tumor Carcinoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Progressive Diffuse Large B-Cell Lymphoma off-label use
Testicular Germ Cell Tumor off-label use
Acute hemorrhage contraindication 8573003
Fibrosis of lung contraindication 51615001 DOID:3770
Metabolic acidosis contraindication 59455009
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Leukopenia contraindication 84828003 DOID:615
Hypoalbuminemia contraindication 119247004
Impaired renal function disorder contraindication 197663003
Drug-induced hepatitis contraindication 235876009
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 13.08 acidic
pKa3 13.86 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 7.30 IUPHAR CHEMBL
Canalicular multispecific organic anion transporter 1 Transporter Km 3.21 WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 2 Transporter WOMBAT-PK
DNA topoisomerase 2-beta Enzyme IC50 7.16 CHEMBL
Multidrug resistance protein 1 Transporter Ki 3.28 WOMBAT-PK
Arachidonate 15-lipoxygenase Enzyme IC50 5.50 DRUG MATRIX

External reference:

IDSource
4018141 VUID
N0000146478 NUI
D00125 KEGG_DRUG
4018141 VANDF
C0015133 UMLSCUI
CHEBI:4911 CHEBI
EVP PDB_CHEM_ID
CHEMBL44657 ChEMBL_ID
D005047 MESH_DESCRIPTOR_UI
DB00773 DRUGBANK_ID
6815 IUPHAR_LIGAND_ID
3835 INN_ID
6PLQ3CP4P3 UNII
36462 PUBCHEM_CID
220347 RXNORM
4209 MMSL
4709 MMSL
6665 MMSL
d00230 MMSL
002674 NDDF
387316009 SNOMEDCT_US
56928005 SNOMEDCT_US
CHEMBL1200645 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9376 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9510 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9511 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9512 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0378-3266 CAPSULE 50 mg ORAL ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5653 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5653 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5656 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5656 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5657 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5657 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 16729-114 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 63323-104 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 14 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 63323-104 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 14 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 68001-265 INJECTION 20 mg INTRAVENOUS ANDA 22 sections