etoposide ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1112 33419-42-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • etoposide
  • etosid
  • fytosid
  • toposar
  • zuyeyidal
  • VP-16
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
  • Molecular weight: 588.56
  • Formula: C29H32O13
  • CLOGP: 0.59
  • LIPINSKI: 2
  • HAC: 13
  • HDO: 3
  • TPSA: 160.83
  • ALOGS: -2.78
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.22 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 38 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.30 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 52 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.12 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.70 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 10, 1983 FDA
March 26, 2019 PMDA BRISTOL-MYERS SQUIBB K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2525.89 15.76 1427 48779 96240 50458678
Neutropenia 1074.75 15.76 1001 49205 146964 50407954
Mucosal inflammation 858.18 15.76 520 49686 39622 50515296
Bone marrow failure 744.40 15.76 416 49790 27208 50527710
Pancytopenia 726.45 15.76 628 49578 83402 50471516
Thrombocytopenia 619.76 15.76 696 49510 126977 50427941
Acute myeloid leukaemia 597.42 15.76 294 49912 14780 50540138
Product use in unapproved indication 539.15 15.76 618 49588 115201 50439717
Myelodysplastic syndrome 517.17 15.76 267 49939 14865 50540053
Haematotoxicity 414.47 15.76 187 50019 7708 50547210
Ovarian failure 392.97 15.76 109 50097 1002 50553916
Haemophagocytic lymphohistiocytosis 343.82 15.76 169 50037 8464 50546454
Off label use 342.75 15.76 1139 49067 473287 50081631
Disease progression 341.09 15.76 447 49759 95419 50459499
Sepsis 328.19 15.76 521 49685 132404 50422514
Myelosuppression 311.58 15.76 184 50022 13333 50541585
Second primary malignancy 307.52 15.76 146 50060 6768 50548150
Neutropenic sepsis 303.82 15.76 184 50022 13963 50540955
Febrile bone marrow aplasia 279.87 15.76 133 50073 6178 50548740
Multiple organ dysfunction syndrome 272.41 15.76 291 49915 50046 50504872
Pain 265.39 15.76 122 50084 578781 49976137
Venoocclusive liver disease 256.08 15.76 111 50095 4150 50550768
Septic shock 250.34 15.76 296 49910 56879 50498039
Tumour lysis syndrome 245.03 15.76 128 50078 7293 50547625
Posterior reversible encephalopathy syndrome 233.42 15.76 159 50047 14769 50540149
Malignant neoplasm progression 233.42 15.76 312 49894 67812 50487106
Neutrophil count decreased 231.42 15.76 256 49950 45770 50509148
Aplasia 221.56 15.76 97 50109 3716 50551202
Arthralgia 219.30 15.76 81 50125 438621 50116297
Joint swelling 215.70 15.76 6 50200 245280 50309638
Diffuse large B-cell lymphoma refractory 200.87 15.76 64 50142 982 50553936
Pyrexia 197.50 15.76 822 49384 379381 50175537
Encephalopathy 182.51 15.76 195 50011 33516 50521402
Anaemia 178.51 15.76 603 49603 251853 50303065
Maternal exposure before pregnancy 177.56 15.76 94 50112 5503 50549415
Peripheral swelling 167.59 15.76 9 50197 205927 50348991
Platelet count decreased 162.29 15.76 328 49878 100398 50454520
Nasopharyngitis 161.59 15.76 7 50199 192920 50361998
Stem cell transplant 160.73 15.76 61 50145 1607 50553311
Leukopenia 153.19 15.76 255 49951 67273 50487645
Abdominal discomfort 152.02 15.76 24 50182 231617 50323301
Drug resistance 149.83 15.76 135 50071 18854 50536064
Diffuse large B-cell lymphoma recurrent 148.91 15.76 57 50149 1538 50553380
Ototoxicity 148.80 15.76 52 50154 1075 50553843
Disease recurrence 147.21 15.76 137 50069 19944 50534974
Venoocclusive disease 146.21 15.76 59 50147 1837 50553081
Drug hypersensitivity 145.81 15.76 35 50171 250975 50303943
Product dose omission issue 138.02 15.76 12 50194 183826 50371092
Fall 133.39 15.76 84 50122 334848 50220070
Teratoma 132.05 15.76 30 50176 107 50554811
Cytomegalovirus infection 130.62 15.76 122 50084 17840 50537078
Contraindicated product administered 129.55 15.76 4 50202 148954 50405964
Neutropenic colitis 129.21 15.76 58 50148 2359 50552559
Systemic lupus erythematosus 125.18 15.76 3 50203 140619 50414299
Pruritus 123.04 15.76 64 50142 283504 50271414
Bacteraemia 122.61 15.76 107 50099 14326 50540592
Aspergillus infection 121.95 15.76 79 50127 6742 50548176
Ovarian germ cell teratoma 119.53 15.76 25 50181 53 50554865
Weight increased 117.50 15.76 28 50178 201863 50353055
Hepatosplenic T-cell lymphoma 117.14 15.76 37 50169 551 50554367
Arthropathy 116.65 15.76 11 50195 157895 50397023
Rash 115.11 15.76 160 50046 437311 50117607
Headache 111.04 15.76 209 49997 506326 50048592
Cardiotoxicity 110.19 15.76 75 50131 6952 50547966
Fatigue 109.66 15.76 350 49856 707251 49847667
Malignant transformation 108.08 15.76 31 50175 325 50554593
Pulmonary haemorrhage 105.88 15.76 71 50135 6421 50548497
Insomnia 104.24 15.76 23 50183 174842 50380076
Musculoskeletal stiffness 103.28 15.76 6 50200 128475 50426443
Oesophagitis 101.37 15.76 93 50113 13290 50541628
Neoplasm progression 100.47 15.76 134 50072 29023 50525895
Swelling 100.25 15.76 37 50169 200835 50354083
Pain in extremity 99.83 15.76 75 50131 272790 50282128
Malaise 97.20 15.76 114 50092 335418 50219500
Cytopenia 95.26 15.76 75 50131 8700 50546218
Graft versus host disease 94.76 15.76 65 50141 6101 50548817
Drug intolerance 94.18 15.76 50 50156 219054 50335864
Candida infection 91.83 15.76 115 50091 23408 50531510
Glossodynia 91.07 15.76 6 50200 115563 50439355
Primary hypogonadism 90.23 15.76 23 50183 147 50554771
Alveolar soft part sarcoma 90.15 15.76 21 50185 86 50554832
Bronchopulmonary aspergillosis 89.19 15.76 68 50138 7524 50547394
Injection site pain 86.80 15.76 6 50200 111018 50443900
Acute graft versus host disease 86.29 15.76 52 50154 3906 50551012
Enterococcal infection 85.95 15.76 64 50142 6834 50548084
Hypokalaemia 85.23 15.76 235 49971 87757 50467161
Neurotoxicity 84.61 15.76 88 50118 14652 50540266
Premature menopause 83.80 15.76 31 50175 759 50554159
Dizziness 82.94 15.76 135 50071 346234 50208684
Therapeutic product effect decreased 82.89 15.76 17 50189 136033 50418885
Colitis 81.37 15.76 141 50065 38388 50516530
Osteosarcoma 81.16 15.76 20 50186 109 50554809
Cystitis haemorrhagic 79.06 15.76 48 50158 3654 50551264
Hypersensitivity 78.83 15.76 59 50147 215102 50339816
Clostridium difficile colitis 77.80 15.76 92 50114 17650 50537268
Fungaemia 75.97 15.76 38 50168 1974 50552944
Anxiety 75.61 15.76 41 50165 177565 50377353
Urticaria 75.28 15.76 18 50188 129543 50425375
Human herpesvirus 6 infection 74.91 15.76 41 50165 2565 50552353
Hepatitis B reactivation 74.66 15.76 38 50168 2049 50552869
Cervix disorder 74.60 15.76 25 50181 453 50554465
Discomfort 73.87 15.76 10 50196 108370 50446548
Asthma 72.31 15.76 4 50202 89333 50465585
Leukoencephalopathy 71.95 15.76 46 50160 3837 50551081
Nephropathy toxic 71.17 15.76 61 50145 7968 50546950
Cytomegalovirus viraemia 70.85 15.76 49 50157 4660 50550258
Teratoma benign 70.44 15.76 16 50190 57 50554861
Thrombotic microangiopathy 70.32 15.76 63 50143 8728 50546190
Muscle spasms 69.95 15.76 19 50187 125534 50429384
Enterobacter infection 69.36 15.76 35 50171 1853 50553065
Respiratory failure 68.84 15.76 223 49983 90958 50463960
Complications of bone marrow transplant 67.33 15.76 23 50183 443 50554475
Disseminated intravascular coagulation 67.24 15.76 84 50122 17051 50537867
White blood cell count decreased 67.11 15.76 261 49945 116461 50438457
Feeling abnormal 66.23 15.76 21 50185 125471 50429447
Acute lymphocytic leukaemia recurrent 65.00 15.76 34 50172 1941 50552977
Renal salt-wasting syndrome 62.88 15.76 19 50187 242 50554676
Capillary leak syndrome 60.67 15.76 32 50174 1858 50553060
Lymphopenia 60.38 15.76 76 50130 15545 50539373
Hypomagnesaemia 60.06 15.76 93 50113 23063 50531855
Human bocavirus infection 60.01 15.76 20 50186 356 50554562
Acute promyelocytic leukaemia 59.64 15.76 25 50181 859 50554059
Overdose 59.63 15.76 13 50193 99714 50455204
Bronchitis 59.47 15.76 15 50191 104144 50450774
Klebsiella infection 58.43 15.76 52 50154 7142 50547776
BK virus infection 58.07 15.76 36 50170 2845 50552073
Sinusitis 57.19 15.76 51 50155 170507 50384411
Gene mutation 56.99 15.76 27 50179 1244 50553674
Graft versus host disease in skin 56.80 15.76 34 50172 2522 50552396
Systemic candida 56.58 15.76 35 50171 2755 50552163
JC virus infection 56.20 15.76 30 50176 1785 50553133
Skin candida 55.91 15.76 27 50179 1299 50553619
Contusion 55.36 15.76 21 50185 112162 50442756
Hospitalisation 55.11 15.76 3 50203 67934 50486984
Large intestinal ulcer perforation 53.86 15.76 13 50193 64 50554854
Injection site erythema 53.29 15.76 6 50200 74930 50479988
Post transplant lymphoproliferative disorder 52.37 15.76 39 50167 4165 50550753
Acute respiratory distress syndrome 52.31 15.76 83 50123 21016 50533902
Therapy partial responder 52.26 15.76 47 50159 6544 50548374
Epstein-Barr virus infection 51.77 15.76 48 50158 6949 50547969
Acute myeloid leukaemia recurrent 51.74 15.76 26 50180 1364 50553554
Progressive multifocal leukoencephalopathy 51.21 15.76 60 50146 11397 50543521
Deafness 50.83 15.76 70 50136 15621 50539297
Herpes simplex 50.82 15.76 48 50158 7114 50547804
Blood pressure increased 50.69 15.76 35 50171 133097 50421821
Myeloid leukaemia 50.58 15.76 17 50189 311 50554607
Mucormycosis 49.98 15.76 31 50175 2452 50552466
Neuropathy peripheral 49.73 15.76 209 49997 96548 50458370
Aplastic anaemia 49.71 15.76 49 50157 7654 50547264
Secondary immunodeficiency 49.51 15.76 24 50182 1164 50553754
Migraine 48.86 15.76 8 50198 75272 50479646
Impaired healing 48.60 15.76 6 50200 69780 50485138
Pleural effusion 48.32 15.76 184 50022 81270 50473648
Staphylococcal bacteraemia 47.24 15.76 39 50167 4838 50550080
Superior vena cava syndrome 47.10 15.76 19 50187 591 50554327
Loss of personal independence in daily activities 46.47 15.76 7 50199 70043 50484875
Ascites 46.45 15.76 107 50099 35754 50519164
Peripheral sensory neuropathy 46.44 15.76 44 50162 6547 50548371
Klebsiella sepsis 46.43 15.76 23 50183 1170 50553748
Neoplasm recurrence 46.23 15.76 29 50177 2340 50552578
Hepatic enzyme increased 46.14 15.76 41 50165 137339 50417579
Pericarditis 45.56 15.76 11 50195 78678 50476240
Encephalitis viral 45.56 15.76 25 50181 1572 50553346
Arthritis 44.89 15.76 15 50191 86706 50468212
Leukaemia 44.79 15.76 33 50173 3466 50551452
Staphylococcal infection 44.74 15.76 105 50101 35511 50519407
Acute graft versus host disease in skin 44.46 15.76 31 50175 2987 50551931
Epstein-Barr virus associated lymphoproliferative disorder 44.25 15.76 25 50181 1664 50553254
Memory impairment 44.20 15.76 12 50194 79348 50475570
Amenorrhoea 44.00 15.76 48 50158 8436 50546482
Suicidal ideation 43.25 15.76 3 50203 55382 50499536
Refractory anaemia with an excess of blasts 43.20 15.76 16 50190 393 50554525
Renal tubular disorder 43.01 15.76 28 50178 2409 50552509
Blood culture positive 42.88 15.76 35 50171 4273 50550645
Pneumonia fungal 42.80 15.76 35 50171 4285 50550633
Acute lymphocytic leukaemia 42.64 15.76 27 50179 2214 50552704
Unmasking of previously unidentified disease 42.64 15.76 19 50187 759 50554159
Influenza like illness 42.41 15.76 4 50202 57455 50497463
Streptococcal bacteraemia 42.08 15.76 23 50183 1435 50553483
Mesenteric abscess 41.68 15.76 11 50195 82 50554836
Inappropriate schedule of product administration 41.66 15.76 10 50196 71821 50483097
Cutaneous calcification 41.11 15.76 11 50195 87 50554831
Congestive cardiomyopathy 41.11 15.76 38 50168 5480 50549438
Adenovirus infection 40.83 15.76 30 50176 3138 50551780
Bacterial infection 40.29 15.76 64 50142 16217 50538701
Diffuse large B-cell lymphoma 40.27 15.76 38 50168 5624 50549294
Gait disturbance 40.17 15.76 54 50152 149951 50404967
Varicella zoster virus infection 40.06 15.76 27 50179 2462 50552456
Sweat gland tumour 40.05 15.76 11 50195 97 50554821
Leukaemia recurrent 39.60 15.76 21 50185 1233 50553685
Medulloblastoma recurrent 39.49 15.76 10 50196 62 50554856
Encephalitis cytomegalovirus 38.83 15.76 16 50190 526 50554392
Abdominal compartment syndrome 38.71 15.76 16 50190 530 50554388
Pneumothorax 38.70 15.76 58 50148 13976 50540942
Respiratory distress 38.42 15.76 90 50116 30399 50524519
Oedema peripheral 38.25 15.76 61 50145 157900 50397018
Nail pigmentation 38.16 15.76 12 50194 176 50554742
Recurrent cancer 38.08 15.76 23 50183 1734 50553184
Clostridium bacteraemia 37.97 15.76 12 50194 179 50554739
Weight decreased 37.95 15.76 104 50102 221141 50333777
Gastrointestinal fungal infection 37.83 15.76 13 50193 255 50554663
Fungal oesophagitis 37.73 15.76 16 50190 566 50554352
Blister 37.38 15.76 19 50187 85399 50469519
Abdominal pain upper 37.20 15.76 63 50143 159246 50395672
Listeria sepsis 37.13 15.76 16 50190 589 50554329
Incorrect dose administered 36.73 15.76 3 50203 48411 50506507
Pneumatosis intestinalis 36.71 15.76 24 50182 2079 50552839
Nasal abscess 36.70 15.76 11 50195 136 50554782
Stress 36.55 15.76 5 50201 53788 50501130
Pulmonary alveolar haemorrhage 36.52 15.76 31 50175 3996 50550922
Enterococcal sepsis 36.48 15.76 20 50186 1255 50553663
Musculoskeletal pain 36.46 15.76 13 50193 72164 50482754
T-cell lymphoma 36.41 15.76 16 50190 618 50554300
Alopecia 35.77 15.76 124 50082 244923 50309995
Blood cholesterol increased 35.53 15.76 6 50200 55209 50499709
Mucocutaneous ulceration 35.38 15.76 11 50195 155 50554763
Leukoerythroblastosis 35.38 15.76 12 50194 226 50554692
Acquired gene mutation 35.27 15.76 17 50189 814 50554104
Therapy non-responder 35.12 15.76 121 50085 50901 50504017
Staphylococcal sepsis 35.09 15.76 39 50167 6997 50547921
Condition aggravated 34.76 15.76 164 50042 296894 50258024
Escherichia bacteraemia 34.61 15.76 27 50179 3089 50551829
Palpitations 34.46 15.76 26 50180 94480 50460438
Gastrointestinal toxicity 34.44 15.76 32 50174 4645 50550273
Splenomegaly 34.19 15.76 45 50161 9615 50545303
Necrotising gastritis 34.12 15.76 9 50197 67 50554851
Venous thrombosis 33.75 15.76 31 50175 4435 50550483
Klebsiella bacteraemia 33.72 15.76 19 50187 1258 50553660
Adverse drug reaction 33.41 15.76 7 50199 55215 50499703
Cardiomyopathy acute 33.31 15.76 11 50195 190 50554728
Hair follicle tumour benign 33.17 15.76 13 50193 374 50554544
Bacterial sepsis 33.15 15.76 28 50178 3584 50551334
Gastroenteritis norovirus 33.12 15.76 21 50185 1726 50553192
Epstein Barr virus positive mucocutaneous ulcer 32.92 15.76 13 50193 382 50554536
Chloroma 32.79 15.76 11 50195 200 50554718
Bone marrow transplant 32.76 15.76 15 50191 639 50554279
Hypogammaglobulinaemia 32.66 15.76 34 50172 5665 50549253
Oesophageal candidiasis 32.66 15.76 32 50174 4962 50549956
Blood glucose increased 32.52 15.76 15 50191 71309 50483609
Basal ganglion degeneration 32.51 15.76 13 50193 395 50554523
Hepatosplenomegaly 32.32 15.76 23 50183 2289 50552629
Dry mouth 32.23 15.76 8 50198 56170 50498748
Injury 32.19 15.76 5 50201 48920 50505998
Hepatitis B 32.09 15.76 27 50179 3439 50551479
Tumour hyperprogression 32.03 15.76 9 50197 87 50554831
Sinus polyp 31.98 15.76 12 50194 306 50554612
T-cell type acute leukaemia 31.96 15.76 8 50198 47 50554871
Peripheral motor neuropathy 31.71 15.76 19 50187 1412 50553506
Tumour necrosis 31.11 15.76 15 50191 719 50554199
Tonsillar haemorrhage 31.09 15.76 11 50195 236 50554682
Subdural hygroma 31.05 15.76 11 50195 237 50554681
Injection site reaction 30.98 15.76 6 50200 50026 50504892
Ill-defined disorder 30.94 15.76 8 50198 54646 50500272
Myocardial infarction 30.57 15.76 26 50180 89001 50465917
White blood cell count abnormal 30.36 15.76 32 50174 5408 50549510
Cytokine release syndrome 30.22 15.76 40 50166 8594 50546324
Metastases to diaphragm 29.79 15.76 7 50199 30 50554888
Rhinovirus infection 29.60 15.76 26 50180 3508 50551410
Pseudomonal sepsis 29.55 15.76 21 50185 2086 50552832
Renal failure 29.51 15.76 194 50012 106439 50448479
Vision blurred 29.50 15.76 21 50185 78626 50476292
Injection site pruritus 29.33 15.76 3 50203 40408 50514510
Tissue infiltration 28.70 15.76 13 50193 540 50554378
Urinary tract infection 28.40 15.76 120 50086 223900 50331018
Cytomegalovirus chorioretinitis 28.29 15.76 18 50188 1489 50553429
Depression 28.17 15.76 78 50128 165345 50389573
Epiphyses premature fusion 28.13 15.76 7 50199 40 50554878
Device related infection 28.10 15.76 63 50143 20672 50534246
Nasal congestion 27.96 15.76 8 50198 51112 50503806
Chronic graft versus host disease 27.92 15.76 23 50183 2844 50552074
Gastrooesophageal reflux disease 27.89 15.76 21 50185 76407 50478511
Drug clearance increased 27.88 15.76 8 50198 84 50554834
Ocular vascular disorder 27.80 15.76 11 50195 325 50554593
Sinoatrial block 27.40 15.76 14 50192 761 50554157
Thymus enlargement 27.22 15.76 8 50198 92 50554826
Trichosporon infection 27.22 15.76 10 50196 240 50554678
Bacterial tracheitis 27.20 15.76 6 50200 18 50554900
International normalised ratio increased 27.09 15.76 5 50201 43147 50511771
Parainfluenzae virus infection 27.01 15.76 19 50187 1856 50553062
Fungal infection 26.99 15.76 78 50128 29887 50525031
Delayed puberty 26.99 15.76 8 50198 95 50554823
Enteritis 26.98 15.76 34 50172 6961 50547957
Femur fracture 26.63 15.76 3 50203 37461 50517457
Acute myelomonocytic leukaemia 26.56 15.76 9 50197 169 50554749
Cardiomyopathy 26.54 15.76 52 50154 15534 50539384
Toxic encephalopathy 26.53 15.76 30 50176 5485 50549433
Plasma cell leukaemia 26.53 15.76 15 50191 1000 50553918
Retinal pigment epitheliopathy 26.36 15.76 9 50197 173 50554745
Vomiting 26.35 15.76 620 49586 460138 50094780
Hyperhidrosis 26.23 15.76 30 50176 89396 50465522
Acute kidney injury 26.10 15.76 343 49863 227715 50327203
Metastases to central nervous system 26.08 15.76 43 50163 11239 50543679
Neck pain 26.02 15.76 12 50194 57055 50497863
Urinary tract infection bacterial 25.99 15.76 26 50180 4133 50550785
Ejection fraction decreased 25.92 15.76 57 50149 18463 50536455
Folliculitis 25.83 15.76 4 50202 39221 50515697
Clostridium colitis 25.82 15.76 18 50188 1734 50553184
Lower respiratory tract infection 25.75 15.76 34 50172 95167 50459751
Paraneoplastic neurological syndrome 25.65 15.76 5 50201 6 50554912
Atypical haemolytic uraemic syndrome 25.49 15.76 12 50194 545 50554373
Metastases to lung 25.47 15.76 42 50164 10978 50543940
Enterocolitis 25.45 15.76 32 50174 6535 50548383
Metastases to lymph nodes 25.29 15.76 33 50173 6991 50547927
Vertigo 25.07 15.76 10 50196 51822 50503096
Burning sensation 25.06 15.76 7 50199 45439 50509479
Respiratory syncytial virus infection 24.96 15.76 28 50178 5074 50549844
Respiratory symptom 24.85 15.76 20 50186 2394 50552524
Listeriosis 24.83 15.76 16 50190 1352 50553566
Back pain 24.83 15.76 123 50083 219907 50335011
Pseudomonas infection 24.63 15.76 38 50168 9392 50545526
Spinal cord paralysis 24.62 15.76 6 50200 31 50554887
Cardiac failure 24.58 15.76 144 50062 75896 50479022
Cerebellar haemangioma 24.52 15.76 7 50199 72 50554846
Hypothyroidism 24.42 15.76 82 50124 34043 50520875
Mobility decreased 24.35 15.76 26 50180 79922 50474996
Myeloproliferative neoplasm 24.33 15.76 11 50195 455 50554463
Cytomegalovirus colitis 24.28 15.76 18 50188 1909 50553009
Somnolence 24.27 15.76 76 50130 154909 50400009
Myalgia 23.97 15.76 55 50151 124264 50430654
Retinoblastoma 23.94 15.76 7 50199 79 50554839
Cytogenetic abnormality 23.82 15.76 11 50195 478 50554440
Unevaluable event 23.78 15.76 8 50198 46058 50508860
Drug abuse 23.76 15.76 15 50191 59831 50495087
Vena cava thrombosis 23.51 15.76 18 50188 2003 50552915
Depressed mood 23.50 15.76 3 50203 34020 50520898
Pericardial effusion 23.42 15.76 67 50139 25522 50529396
Mouth ulceration 23.39 15.76 71 50135 27953 50526965
Wrong technique in product usage process 23.32 15.76 13 50193 55497 50499421
Uterine enlargement 23.22 15.76 14 50192 1052 50553866
Chronic obstructive pulmonary disease 23.20 15.76 12 50194 53423 50501495
Toxic neuropathy 23.11 15.76 10 50196 372 50554546
Pulmonary toxicity 23 15.76 28 50178 5534 50549384
Hypoxia 22.89 15.76 106 50100 51017 50503901
Radiation pneumonitis 22.73 15.76 15 50191 1320 50553598
Tachycardia 22.64 15.76 173 50033 99590 50455328
Respiratory tract infection fungal 22.62 15.76 10 50196 392 50554526
Dyspnoea 22.60 15.76 395 49811 547213 50007705
B-cell lymphoma recurrent 22.59 15.76 10 50196 393 50554525
Hepatic failure 22.59 15.76 77 50129 32206 50522712
Cytokine storm 22.58 15.76 9 50197 271 50554647
Metastases to bone marrow 22.46 15.76 9 50197 275 50554643
Neutrophil count abnormal 22.44 15.76 19 50187 2440 50552478
Hypophosphataemia 22.10 15.76 34 50172 8380 50546538
Abortion spontaneous 22.01 15.76 7 50199 41765 50513153
Stenotrophomonas infection 21.95 15.76 16 50190 1653 50553265
Suicide attempt 21.90 15.76 12 50194 51720 50503198
Hypoglycaemia 21.87 15.76 13 50193 53568 50501350
Iris atrophy 21.74 15.76 6 50200 54 50554864
Vulvovaginal inflammation 21.65 15.76 11 50195 591 50554327
Streptococcal sepsis 21.63 15.76 16 50190 1691 50553227
Vulvovaginitis 21.56 15.76 9 50197 306 50554612
Genotoxicity 21.56 15.76 5 50201 20 50554898
Follicular thyroid cancer 21.54 15.76 6 50200 56 50554862
Paranasal sinus mucosal hypertrophy 21.36 15.76 5 50201 21 50554897
Hepatic lesion 21.35 15.76 23 50183 3985 50550933
Serum ferritin increased 21.21 15.76 26 50180 5176 50549742
Metastases to spleen 21.19 15.76 7 50199 121 50554797
Renal impairment 21.13 15.76 138 50068 75523 50479395
Retroperitoneal abscess 20.83 15.76 7 50199 128 50554790
Primary mediastinal large B-cell lymphoma recurrent 20.82 15.76 6 50200 64 50554854
Schistocytosis 20.82 15.76 5 50201 24 50554894
Exposure during pregnancy 20.64 15.76 57 50149 120958 50433960
Acute monocytic leukaemia 20.58 15.76 6 50200 67 50554851
Sleep disorder 20.57 15.76 16 50190 57267 50497651
Pulmonary vascular disorder 20.52 15.76 9 50197 346 50554572
Ganglioneuroma 20.48 15.76 7 50199 135 50554783
Neutropenic infection 20.44 15.76 13 50193 1074 50553844
Blood pressure systolic increased 20.43 15.76 5 50201 35444 50519474
Anaesthesia 20.40 15.76 9 50197 351 50554567
Gliosis 20.26 15.76 8 50198 235 50554683
Loss of consciousness 20.25 15.76 46 50160 104307 50450611
Viral haemorrhagic cystitis 20.19 15.76 11 50195 682 50554236
Gastrointestinal mucosal disorder 20.13 15.76 11 50195 686 50554232
Alpha haemolytic streptococcal infection 20.11 15.76 12 50194 885 50554033
Enterobacter bacteraemia 20.10 15.76 8 50198 240 50554678
Surgery 20.07 15.76 3 50203 30202 50524716
Rectal fissure 20.05 15.76 10 50196 516 50554402
Diabetes mellitus 19.86 15.76 12 50194 49021 50505897
Myelopathy 19.79 15.76 18 50188 2543 50552375
Blood stem cell transplant failure 19.75 15.76 7 50199 151 50554767
Fungal sepsis 19.73 15.76 13 50193 1141 50553777
Metastasis 19.70 15.76 23 50183 4352 50550566
VIth nerve paresis 19.67 15.76 6 50200 79 50554839
Neurological decompensation 19.62 15.76 17 50189 2253 50552665
Listeria encephalitis 19.62 15.76 8 50198 256 50554662
Infusion related reaction 19.57 15.76 94 50112 169463 50385455
Dry eye 19.55 15.76 4 50202 32091 50522827
Nervous system disorder 19.47 15.76 47 50159 16176 50538742
Odynophagia 19.46 15.76 28 50178 6504 50548414
Radiation oesophagitis 19.39 15.76 8 50198 264 50554654
Cytomegalovirus infection reactivation 19.37 15.76 18 50188 2613 50552305
Pneumocystis jirovecii pneumonia 19.25 15.76 44 50162 14619 50540299
Wheezing 19.09 15.76 20 50186 62027 50492891
Amnesia 19.09 15.76 9 50197 42251 50512667
Metastases to breast 19.08 15.76 8 50198 275 50554643
Rash pruritic 18.98 15.76 12 50194 47834 50507084
Confusional state 18.71 15.76 108 50098 185820 50369098
Adrenocortical carcinoma 18.64 15.76 5 50201 40 50554878
Cerebral salt-wasting syndrome 18.53 15.76 5 50201 41 50554877
Mesenteric haemorrhage 18.53 15.76 5 50201 41 50554877
Lung infiltration 18.49 15.76 41 50165 13352 50541566
Mucosal erosion 18.45 15.76 13 50193 1274 50553644
Choriocarcinoma 18.42 15.76 5 50201 42 50554876
Fluid retention 18.37 15.76 14 50192 50635 50504283
Stomatitis 18.32 15.76 167 50039 101177 50453741
Drug ineffective 18.26 15.76 648 49558 818685 49736233
Oral fungal infection 18.23 15.76 17 50189 2478 50552440
Embolism 18.08 15.76 28 50178 6940 50547978
Pneumonia respiratory syncytial viral 18.06 15.76 10 50196 640 50554278
Hypoglossal nerve paresis 18.05 15.76 6 50200 106 50554812
Intra-abdominal haemorrhage 17.93 15.76 16 50190 2204 50552714
Left ventricular dysfunction 17.83 15.76 35 50171 10471 50544447
Ewing's sarcoma 17.75 15.76 3 50203 0 50554918
Transdifferentiation of neoplasm 17.66 15.76 4 50202 14 50554904
Hot flush 17.63 15.76 11 50195 44158 50510760
Agranulocytosis 17.62 15.76 54 50152 21367 50533551
Product administered to patient of inappropriate age 17.47 15.76 17 50189 2613 50552305
Vascular compression 17.45 15.76 6 50200 118 50554800
Cardiopulmonary failure 17.34 15.76 19 50187 3354 50551564
Haematochezia 17.25 15.76 9 50197 39873 50515045
Carcinoid crisis 17.16 15.76 7 50199 224 50554694
Angiocentric lymphoma 16.68 15.76 9 50197 547 50554371
Aortic thrombosis 16.57 15.76 11 50195 978 50553940
Hyperkalaemia 16.56 15.76 14 50192 48075 50506843
Human chorionic gonadotropin increased 16.47 15.76 12 50194 1239 50553679
Growth hormone deficiency 16.41 15.76 6 50200 142 50554776
Skin discolouration 16.37 15.76 6 50200 32751 50522167
Osteosarcoma metastatic 16.20 15.76 4 50202 22 50554896
Osteonecrosis of jaw 16.18 15.76 6 50200 32520 50522398
Meningoencephalitis bacterial 16.18 15.76 5 50201 69 50554849
B precursor type acute leukaemia 16.06 15.76 6 50200 151 50554767
Rhabdomyosarcoma recurrent 15.91 15.76 4 50202 24 50554894
Acute graft versus host disease in liver 15.90 15.76 9 50197 601 50554317
Low cardiac output syndrome 15.89 15.76 7 50199 272 50554646
Immune-mediated enterocolitis 15.88 15.76 11 50195 1049 50553869
Pharyngeal inflammation 15.87 15.76 9 50197 603 50554315

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 2877.07 14.68 2243 66348 109997 29395939
Neutropenia 950.15 14.68 1337 67254 130374 29375562
Mucosal inflammation 692.97 14.68 579 68012 31016 29474920
Bone marrow failure 662.74 14.68 532 68059 26917 29479019
Pancytopenia 588.89 14.68 838 67753 82330 29423606
Acute myeloid leukaemia 575.33 14.68 399 68192 16114 29489822
Product use in unapproved indication 569.49 14.68 844 67747 86031 29419905
Myelodysplastic syndrome 534.88 14.68 393 68198 17401 29488535
Thrombocytopenia 509.53 14.68 1026 67565 133797 29372139
Myelosuppression 482.05 14.68 319 68272 11908 29494028
Off label use 450.47 14.68 1622 66969 299178 29206758
Haematotoxicity 347.43 14.68 208 68383 6491 29499445
Venoocclusive liver disease 346.41 14.68 210 68381 6707 29499229
Second primary malignancy 308.87 14.68 193 68398 6512 29499424
Malignant neoplasm progression 290.15 14.68 572 68019 73287 29432649
Disease progression 265.19 14.68 586 68005 81330 29424606
Sepsis 261.36 14.68 825 67766 141857 29364079
Tumour lysis syndrome 250.76 14.68 228 68363 13656 29492280
Septic shock 246.22 14.68 485 68106 62075 29443861
Febrile bone marrow aplasia 245.10 14.68 173 68418 7178 29498758
Neutrophil count decreased 226.30 14.68 381 68210 43186 29462750
Neutropenic sepsis 214.56 14.68 194 68397 11533 29494403
Fall 210.89 14.68 74 68517 177104 29328832
Diffuse large B-cell lymphoma recurrent 209.84 14.68 108 68483 2489 29503447
Neoplasm progression 189.89 14.68 225 68366 18387 29487549
Haemophagocytic lymphohistiocytosis 186.74 14.68 171 68420 10333 29495603
Leukopenia 184.25 14.68 400 68191 54803 29451133
Cytopenia 180.16 14.68 163 68428 9696 29496240
Product dose omission issue 171.07 14.68 14 68577 96369 29409567
Malignant transformation 161.91 14.68 64 68527 770 29505166
Therapy partial responder 158.75 14.68 116 68475 5083 29500853
Posterior reversible encephalopathy syndrome 147.74 14.68 140 68451 8836 29497100
Pyrexia 141.27 14.68 1143 67448 286479 29219457
Dizziness 140.29 14.68 140 68451 189544 29316392
Cardiotoxicity 136.20 14.68 102 68489 4642 29501294
Diffuse large B-cell lymphoma refractory 135.59 14.68 58 68533 864 29505072
Fatigue 134.70 14.68 339 68252 316482 29189454
Venoocclusive disease 132.05 14.68 79 68512 2460 29503476
Stomatitis 130.76 14.68 275 68316 36838 29469098
Bronchopulmonary aspergillosis 130.50 14.68 152 68439 12192 29493744
Cystitis haemorrhagic 129.95 14.68 100 68491 4742 29501194
Aplasia 129.39 14.68 93 68498 3970 29501966
Overdose 123.07 14.68 19 68572 79800 29426136
Aspergillus infection 121.51 14.68 136 68455 10445 29495491
Stem cell transplant 119.67 14.68 68 68523 1919 29504017
Bacteraemia 115.88 14.68 165 68426 16158 29489778
Arthralgia 113.93 14.68 94 68497 139523 29366413
Insomnia 112.67 14.68 33 68558 88728 29417208
Depression 109.28 14.68 31 68560 85116 29420820
Neoplasm recurrence 106.69 14.68 63 68528 1914 29504022
Encephalopathy 104.69 14.68 226 68365 30817 29475119
Fungal infection 104.09 14.68 143 68448 13542 29492394
Neutropenic colitis 102.53 14.68 66 68525 2345 29503591
Drug interaction 102.12 14.68 189 68402 197196 29308740
Joint swelling 101.26 14.68 3 68588 49627 29456309
Anaemia 100.76 14.68 803 67788 200148 29305788
Malaise 100.41 14.68 134 68457 159468 29346468
Tremor 99.65 14.68 24 68567 73514 29432422
Peripheral swelling 98.64 14.68 15 68576 63724 29442212
Blood pressure increased 98.23 14.68 25 68566 73778 29432158
Acute graft versus host disease 98.06 14.68 92 68499 5732 29500204
Pain 97.02 14.68 155 68436 171277 29334659
Respiratory failure 94.80 14.68 461 68130 96670 29409266
Anxiety 94.19 14.68 40 68551 85325 29420611
Rash 92.74 14.68 188 68403 189631 29316305
Disease recurrence 90.40 14.68 145 68446 15769 29490167
Multiple organ dysfunction syndrome 81.64 14.68 326 68265 62790 29443146
Drug resistance 81 14.68 164 68427 21376 29484560
Hepatitis B reactivation 80.82 14.68 64 68527 3165 29502771
Cytomegalovirus infection 78.25 14.68 169 68422 23046 29482890
Death 77.55 14.68 471 68120 341613 29164323
Anaplastic lymphoma kinase gene mutation 74.79 14.68 22 68569 96 29505840
Sweat gland tumour 74.36 14.68 30 68561 382 29505554
Progressive multifocal leukoencephalopathy 73.79 14.68 96 68495 8623 29497313
Enterococcal bacteraemia 72.79 14.68 45 68546 1488 29504448
White blood cell count decreased 71.05 14.68 381 68210 82981 29422955
Renal salt-wasting syndrome 69.88 14.68 23 68568 155 29505781
Inappropriate schedule of product administration 69.87 14.68 10 68581 44462 29461474
Cardiac failure congestive 69.59 14.68 46 68545 76535 29429401
Neurotoxicity 68.21 14.68 122 68469 14491 29491445
Musculoskeletal stiffness 67.65 14.68 5 68586 37453 29468483
Colitis 67.64 14.68 192 68399 31056 29474880
Nasopharyngitis 67.35 14.68 27 68564 59638 29446298
Weight increased 67.08 14.68 48 68543 76619 29429317
Coronary artery disease 67.00 14.68 11 68580 44179 29461757
Nephropathy toxic 66.63 14.68 102 68489 10654 29495282
Somnolence 66.33 14.68 72 68519 93883 29412053
Systemic mycosis 65.84 14.68 40 68551 1281 29504655
Pruritus 65.70 14.68 106 68485 116743 29389193
Clostridium difficile colitis 65.16 14.68 113 68478 13099 29492837
Pulmonary toxicity 65.16 14.68 68 68523 4822 29501114
Lymphopenia 64.48 14.68 114 68477 13419 29492517
Aggression 63.46 14.68 5 68586 35536 29470400
Candida infection 62.16 14.68 120 68471 15105 29490831
Cytomegalovirus chorioretinitis 62.04 14.68 55 68536 3183 29502753
Muscle spasms 62.02 14.68 37 68554 65045 29440891
Hepatitis B 61.99 14.68 70 68521 5427 29500509
Weight decreased 61.92 14.68 164 68427 150741 29355195
Acute promyelocytic leukaemia 61.54 14.68 27 68564 429 29505507
Adenovirus infection 61.34 14.68 63 68528 4384 29501552
Platelet count decreased 61.17 14.68 434 68157 104238 29401698
Oedema peripheral 61.02 14.68 91 68500 103466 29402470
Feeling abnormal 60.86 14.68 25 68566 54420 29451516
Epstein-Barr virus infection 60.85 14.68 76 68515 6553 29499383
Chest pain 60.70 14.68 104 68487 111869 29394067
BK virus infection 60.13 14.68 64 68527 4643 29501293
Blood glucose increased 59.86 14.68 31 68560 58953 29446983
Enterococcal infection 59.29 14.68 84 68507 8184 29497752
Osteosarcoma 59.23 14.68 21 68570 182 29505754
Renal tubular disorder 58.85 14.68 61 68530 4291 29501645
Myocardial infarction 58.37 14.68 104 68487 110192 29395744
Headache 57.98 14.68 208 68383 173799 29332137
Myalgia 56.48 14.68 53 68538 73966 29431970
Chronic graft versus host disease 55.43 14.68 57 68534 3972 29501964
Staphylococcal bacteraemia 55.38 14.68 75 68516 7004 29498932
Lymphadenopathy 55.27 14.68 155 68436 24894 29481042
Neuropathy peripheral 54.75 14.68 316 68275 70711 29435225
Asthma 54.62 14.68 7 68584 33842 29472094
Pneumonitis 53.72 14.68 165 68426 27879 29478057
Chloroma 53.61 14.68 25 68566 461 29505475
Rhabdomyolysis 53.27 14.68 38 68553 60770 29445166
Hospitalisation 53.24 14.68 20 68571 45968 29459968
Cerebrovascular accident 53.11 14.68 60 68531 76851 29429085
Hypogammaglobulinaemia 53.07 14.68 67 68524 5840 29500096
Pneumonia klebsiella 52.84 14.68 46 68545 2598 29503338
Thrombotic microangiopathy 51.92 14.68 81 68510 8600 29497336
Pneumocystis jirovecii pneumonia 51.86 14.68 118 68473 16661 29489275
Vena cava thrombosis 51.19 14.68 31 68560 987 29504949
Incorrect dose administered 50.47 14.68 8 68583 32976 29472960
Acute graft versus host disease in skin 50.23 14.68 58 68533 4606 29501330
Drug hypersensitivity 49.86 14.68 51 68540 68355 29437581
Bacterial sepsis 49.84 14.68 58 68533 4645 29501291
Pulmonary vascular disorder 49.53 14.68 25 68566 552 29505384
Hyperkalaemia 49.18 14.68 42 68549 61350 29444586
Epstein-Barr virus associated lymphoproliferative disorder 49.07 14.68 37 68554 1701 29504235
Ameloblastoma 48.69 14.68 15 68576 79 29505857
Retinal haemorrhage 48.49 14.68 56 68535 4448 29501488
Diffuse large B-cell lymphoma 48.35 14.68 66 68525 6210 29499726
Azoospermia 48.32 14.68 22 68569 383 29505553
Blood stem cell transplant failure 47.66 14.68 22 68569 396 29505540
Pain in extremity 47.60 14.68 117 68474 110316 29395620
Papillary thyroid cancer 46.43 14.68 24 68567 558 29505378
Klebsiella sepsis 45.67 14.68 35 68556 1649 29504287
Influenza like illness 44.95 14.68 3 68588 24467 29481469
B-cell lymphoma recurrent 44.89 14.68 24 68567 599 29505337
Gait disturbance 44.62 14.68 63 68528 73286 29432650
Agranulocytosis 44.03 14.68 125 68466 20215 29485721
Arthritis 43.35 14.68 4 68587 25015 29480921
Refractory cancer 43.14 14.68 15 68576 122 29505814
Escherichia infection 43.10 14.68 65 68526 6699 29499237
Balance disorder 43.10 14.68 15 68576 36155 29469781
Salivary gland cancer 43.08 14.68 18 68573 252 29505684
Chronic obstructive pulmonary disease 42.33 14.68 21 68570 40934 29465002
Acute respiratory distress syndrome 42.13 14.68 133 68458 22802 29483134
Blood creatine phosphokinase increased 41.77 14.68 21 68570 40623 29465313
Fusarium infection 41.67 14.68 27 68564 970 29504966
Acute lymphocytic leukaemia 41.32 14.68 40 68551 2591 29503345
Bradycardia 41.29 14.68 55 68536 65574 29440362
Pulmonary arteriopathy 41.06 14.68 13 68578 76 29505860
Bacterial infection 41.06 14.68 92 68499 12856 29493080
Vision blurred 40.93 14.68 21 68570 40155 29465781
Graft versus host disease 40.67 14.68 77 68514 9551 29496385
Hallucination 40.41 14.68 27 68564 44685 29461251
Hypoglycaemia 40.05 14.68 32 68559 48314 29457622
Sleep disorder 39.45 14.68 5 68586 24381 29481555
Abdominal discomfort 39.32 14.68 32 68559 47871 29458065
Loss of personal independence in daily activities 39.31 14.68 6 68585 25434 29480502
Nephrolithiasis 39.09 14.68 6 68585 25328 29480608
Central nervous system fungal infection 39.04 14.68 18 68573 323 29505613
Rheumatoid arthritis 38.89 14.68 13 68578 32139 29473797
Diaphragm muscle weakness 38.54 14.68 14 68577 131 29505805
Urinary tract infection 38.46 14.68 68 68523 72286 29433650
Unevaluable event 38.02 14.68 11 68580 29840 29476096
Recurrent cancer 37.86 14.68 27 68564 1138 29504798
Hyperhidrosis 37.72 14.68 57 68534 64483 29441453
Psoriasis 37.32 14.68 14 68577 32213 29473723
Ototoxicity 37.00 14.68 30 68561 1535 29504401
Drug reaction with eosinophilia and systemic symptoms 36.24 14.68 10 68581 27982 29477954
Diabetes mellitus 36.06 14.68 24 68567 39807 29466129
Heart rate decreased 36.02 14.68 7 68584 24905 29481031
Systemic candida 35.86 14.68 38 68553 2742 29503194
Metastasis 35.86 14.68 42 68549 3387 29502549
Medulloblastoma recurrent 35.54 14.68 11 68580 59 29505877
Loss of consciousness 35.52 14.68 74 68517 73982 29431954
Teratoma 35.45 14.68 9 68582 19 29505917
Osteonecrosis 35.23 14.68 89 68502 13430 29492506
Urticaria 35.21 14.68 45 68546 54615 29451321
Escherichia bacteraemia 34.99 14.68 38 68553 2820 29503116
Metastases to meninges 34.79 14.68 26 68565 1179 29504757
Pseudomonas infection 34.29 14.68 77 68514 10775 29495161
Leukaemia recurrent 34.26 14.68 28 68563 1449 29504487
Back pain 34.19 14.68 122 68469 102162 29403774
Klebsiella infection 33.84 14.68 61 68530 7288 29498648
Juvenile melanoma benign 33.83 14.68 11 68580 71 29505865
Electrocardiogram QT prolonged 33.78 14.68 21 68570 36116 29469820
Angioedema 33.54 14.68 16 68575 31899 29474037
Dyspnoea 33.48 14.68 545 68046 326187 29179749
Viral haemorrhagic cystitis 33.37 14.68 23 68568 917 29505019
Retinopathy proliferative 33.31 14.68 11 68580 75 29505861
Extravasation 33.23 14.68 29 68562 1643 29504293
Therapy non-responder 33.22 14.68 151 68440 30760 29475176
Ganglioneuroblastoma 33.21 14.68 9 68582 27 29505909
Metastases to liver 32.95 14.68 80 68511 11776 29494160
Aortic thrombosis 32.36 14.68 20 68571 661 29505275
Fanconi syndrome 32.33 14.68 28 68563 1570 29504366
Neuroblastoma 31.81 14.68 12 68579 126 29505810
Memory impairment 31.66 14.68 23 68568 36447 29469489
Pulmonary veno-occlusive disease 31.48 14.68 17 68574 433 29505503
Cellulitis gangrenous 31.24 14.68 13 68578 180 29505756
Delayed puberty 30.92 14.68 13 68578 185 29505751
Gastrointestinal toxicity 30.87 14.68 31 68560 2100 29503836
Pneumonia aspiration 30.82 14.68 24 68567 36713 29469223
Stenotrophomonas infection 30.60 14.68 28 68563 1689 29504247
Injury 30.58 14.68 4 68587 19042 29486894
Cardiac disorder 30.44 14.68 25 68566 37238 29468698
Toxic encephalopathy 30.36 14.68 45 68546 4567 29501369
Aspiration bone marrow abnormal 30.18 14.68 11 68580 104 29505832
Haematochezia 29.98 14.68 25 68566 36958 29468978
Carotid artery thrombosis 29.85 14.68 15 68576 328 29505608
Minimal residual disease 29.85 14.68 15 68576 328 29505608
Serotonin syndrome 29.81 14.68 3 68588 17509 29488427
Metastases to muscle 29.55 14.68 13 68578 208 29505728
Flagellate dermatitis 29.52 14.68 8 68583 24 29505912
Mucormycosis 29.28 14.68 47 68544 5111 29500825
Peripheral T-cell lymphoma unspecified 29.23 14.68 16 68575 419 29505517
Metastases to retroperitoneum 29.21 14.68 13 68578 214 29505722
Abdominal pain upper 29.20 14.68 61 68530 60932 29445004
Device related infection 29.01 14.68 91 68500 15545 29490391
Cytogenetic abnormality 28.99 14.68 20 68571 799 29505137
Wheezing 28.81 14.68 21 68570 33219 29472717
Streptococcal bacteraemia 28.75 14.68 27 68564 1684 29504252
Hepatic candidiasis 28.66 14.68 9 68582 51 29505885
Human herpesvirus 6 infection 28.65 14.68 28 68563 1835 29504101
Body height below normal 28.62 14.68 13 68578 225 29505711
Metastases to lung 28.56 14.68 59 68532 7796 29498140
Gastrooesophageal reflux disease 28.48 14.68 19 68572 31477 29474459
Engraftment syndrome 28.46 14.68 20 68571 823 29505113
Disseminated intravascular coagulation 28.08 14.68 106 68485 19874 29486062
Rhabdomyosarcoma recurrent 28.07 14.68 10 68581 88 29505848
Paraneoplastic neurological syndrome 27.95 14.68 8 68583 31 29505905
Contusion 27.80 14.68 19 68572 31076 29474860
Refractory anaemia with an excess of blasts 27.78 14.68 15 68576 382 29505554
Pulmonary haemorrhage 27.33 14.68 64 68527 9206 29496730
Cytomegalovirus viraemia 27.26 14.68 51 68540 6269 29499667
Enteritis 27.07 14.68 53 68538 6738 29499198
Hepatotoxicity 26.96 14.68 97 68494 17770 29488166
Encephalitis enteroviral 26.86 14.68 11 68580 146 29505790
Diabetic ketoacidosis 26.73 14.68 3 68588 16070 29489866
Cardio-respiratory arrest 26.48 14.68 48 68543 50553 29455383
Influenza 26.44 14.68 35 68556 41846 29464090
Capillary leak syndrome 26.37 14.68 27 68564 1872 29504064
Lactic acidosis 26.35 14.68 19 68572 30228 29475708
Intussusception 26.24 14.68 16 68575 516 29505420
Erectile dysfunction 26.16 14.68 5 68586 18004 29487932
Swelling 26.04 14.68 26 68565 35257 29470679
Intestinal atresia 26.01 14.68 9 68582 72 29505864
Hypoalbuminaemia 25.98 14.68 67 68524 10238 29495698
Wrong technique in product usage process 25.78 14.68 21 68570 31407 29474529
Blood cholesterol increased 25.71 14.68 3 68588 15592 29490344
Herpes simplex 25.66 14.68 43 68548 4847 29501089
Mobility decreased 25.48 14.68 14 68577 25766 29480170
Candida sepsis 25.44 14.68 21 68570 1102 29504834
Cytomegalovirus infection reactivation 25.34 14.68 35 68556 3329 29502607
Embolism 25.31 14.68 52 68539 6844 29499092
Adverse drug reaction 25.30 14.68 12 68579 24008 29481928
Metastases to central nervous system 25.27 14.68 53 68538 7078 29498858
Abnormal behaviour 25.22 14.68 11 68580 23116 29482820
Bronchitis 25.17 14.68 29 68562 36839 29469097
Eosinophilia 25.04 14.68 10 68581 22151 29483785
Prostate cancer 25.03 14.68 14 68577 25513 29480423
Hepatic infection fungal 25.00 14.68 11 68580 176 29505760
Acute lymphocytic leukaemia recurrent 24.96 14.68 30 68561 2486 29503450
Blood lactate dehydrogenase increased 24.62 14.68 99 68492 19110 29486826
Toxicity to various agents 24.51 14.68 271 68320 173390 29332546
Dyskinesia 24.45 14.68 8 68583 20053 29485883
Streptococcal infection 24.26 14.68 40 68551 4448 29501488
Treatment noncompliance 24.17 14.68 13 68578 24214 29481722
Liver function test abnormal 24.12 14.68 19 68572 28899 29477037
Gastrointestinal mucosal disorder 23.90 14.68 13 68578 336 29505600
Blood pressure systolic increased 23.80 14.68 5 68586 16840 29489096
Therapeutic product effect decreased 23.76 14.68 20 68571 29431 29476505
Neoplasm 23.74 14.68 38 68553 4123 29501813
Myelopathy 23.74 14.68 26 68565 1948 29503988
Myeloid leukaemia 23.73 14.68 13 68578 341 29505595
Short stature 23.69 14.68 8 68583 59 29505877
Disturbance in attention 23.67 14.68 10 68581 21414 29484522
Flatulence 23.54 14.68 6 68585 17703 29488233
Geotrichum infection 23.54 14.68 14 68577 431 29505505
Trichosporon infection 23.53 14.68 16 68575 624 29505312
Hyperbilirubinaemia 23.32 14.68 82 68509 14852 29491084
Accidental overdose 23.31 14.68 6 68585 17587 29488349
Graft versus host disease in gastrointestinal tract 23.21 14.68 33 68558 3225 29502711
Epstein-Barr virus infection reactivation 23.20 14.68 15 68576 537 29505399
Arrhythmia 23.20 14.68 23 68568 31290 29474646
Hypertensive hydrocephalus 23.12 14.68 8 68583 64 29505872
Blood electrolytes abnormal 22.92 14.68 18 68573 879 29505057
Nervous system disorder 22.81 14.68 73 68518 12601 29493335
Hypophosphataemia 22.59 14.68 54 68537 7870 29498066
Transformation to acute myeloid leukaemia 22.34 14.68 16 68575 679 29505257
Neuroblastoma recurrent 22.30 14.68 8 68583 72 29505864
Graft versus host disease in skin 22.29 14.68 33 68558 3346 29502590
Head injury 22.26 14.68 5 68586 16076 29489860
Syncope 22.21 14.68 105 68486 81266 29424670
Carbamoyl phosphate synthetase deficiency 22.14 14.68 6 68585 18 29505918
Mantle cell lymphoma recurrent 22.09 14.68 14 68577 484 29505452
Papilloedema 21.94 14.68 27 68564 2293 29503643
Graft versus host disease in liver 21.91 14.68 19 68572 1067 29504869
Neutrophil count abnormal 21.87 14.68 22 68569 1493 29504443
Bicytopenia 21.86 14.68 24 68567 1803 29504133
Dehydration 21.85 14.68 166 68425 114582 29391354
Cardiac arrest 21.33 14.68 114 68477 85477 29420459
T-cell type acute leukaemia 21.29 14.68 8 68583 83 29505853
Aplastic anaemia 21.22 14.68 51 68540 7459 29498477
Radiation pneumonitis 21.17 14.68 26 68565 2203 29503733
Stomatitis necrotising 21.12 14.68 8 68583 85 29505851
Transient ischaemic attack 21.09 14.68 14 68577 23256 29482680
Escherichia sepsis 21.09 14.68 35 68556 3914 29502022
Flushing 21.03 14.68 127 68464 28865 29477071
Faeces discoloured 20.97 14.68 3 68588 13348 29492588
Autoimmune neutropenia 20.96 14.68 11 68580 264 29505672
Peripheral sensory neuropathy 20.88 14.68 44 68547 5895 29500041
Rectal haemorrhage 20.67 14.68 30 68561 34519 29471417
Nasal congestion 20.56 14.68 9 68582 18870 29487066
Traumatic lung injury 20.56 14.68 19 68572 1161 29504775
Gallbladder empyema 20.23 14.68 7 68584 56 29505880
Metastases to spleen 20.22 14.68 12 68579 368 29505568
Visceral oedema 20.22 14.68 5 68586 9 29505927
Adrenocortical carcinoma 20.07 14.68 6 68585 28 29505908
Skin exfoliation 20.02 14.68 14 68577 22631 29483305
Diverticulitis 19.98 14.68 8 68583 17696 29488240
Pneumonia adenoviral 19.96 14.68 9 68582 153 29505783
Hepatosplenomegaly 19.92 14.68 33 68558 3684 29502252
Inflammatory pseudotumour 19.90 14.68 6 68585 29 29505907
International normalised ratio increased 19.89 14.68 46 68545 44326 29461610
Emotional distress 19.89 14.68 4 68587 13891 29492045
Dry mouth 19.89 14.68 13 68578 21771 29484165
Dry skin 19.84 14.68 15 68576 23292 29482644
Chromaturia 19.82 14.68 3 68588 12799 29493137
Intestinal perforation 19.79 14.68 52 68539 8034 29497902
Basal cell naevus syndrome 19.73 14.68 6 68585 30 29505906
Enterocolitis 19.62 14.68 46 68545 6620 29499316
Leukoencephalopathy 19.60 14.68 33 68558 3734 29502202
Testicular malignant teratoma 19.55 14.68 5 68586 11 29505925
Lung infiltration 19.55 14.68 66 68525 11713 29494223
Heart rate increased 19.43 14.68 38 68553 38900 29467036
Osteonecrosis of jaw 19.40 14.68 7 68584 16503 29489433
Pneumonia fungal 19.39 14.68 42 68549 5735 29500201
Road traffic accident 19.33 14.68 6 68585 15555 29490381
Laboratory test abnormal 19.28 14.68 9 68582 18176 29487760
Staphylococcal infection 19.28 14.68 125 68466 29115 29476821
Arterial thrombosis 19.28 14.68 20 68571 1408 29504528
Paternal exposure timing unspecified 19.26 14.68 6 68585 33 29505903
Small cell lung cancer 19.22 14.68 22 68569 1730 29504206
Meningitis tuberculous 19.20 14.68 14 68577 611 29505325
Confusional state 19.06 14.68 197 68394 127680 29378256
Therapy responder 19.06 14.68 9 68582 171 29505765
Pneumocystis jirovecii infection 19.05 14.68 20 68571 1428 29504508
Migraine 19.05 14.68 3 68588 12427 29493509
Acute myelomonocytic leukaemia 19.02 14.68 8 68583 114 29505822
Speech disorder 18.93 14.68 16 68575 23500 29482436
Amnesia 18.73 14.68 15 68576 22628 29483308
Myoclonus 18.70 14.68 4 68587 13305 29492631
Chronic myeloid leukaemia 18.52 14.68 23 68568 1971 29503965
Scedosporium infection 18.46 14.68 15 68576 770 29505166
Diabetes mellitus inadequate control 18.43 14.68 3 68588 12131 29493805
Splenic infarction 18.36 14.68 22 68569 1817 29504119
Spindle cell sarcoma 18.24 14.68 8 68583 127 29505809
Reticulocytosis 18.23 14.68 10 68581 263 29505673
Metastases to lymph nodes 18.06 14.68 33 68558 3984 29501952
Dystrophic calcification 18.04 14.68 4 68587 3 29505933
Premature ageing 18.03 14.68 7 68584 80 29505856
Refractory cytopenia with multilineage dysplasia 17.96 14.68 8 68583 132 29505804
Asthenia 17.91 14.68 372 68219 214878 29291058
Autoimmune haemolytic anaemia 17.79 14.68 32 68559 3816 29502120
B-cell lymphoma refractory 17.74 14.68 8 68583 136 29505800
Subdural haemorrhage 17.72 14.68 27 68564 2808 29503128
Myelitis transverse 17.71 14.68 16 68575 949 29504987
Cerebral toxoplasmosis 17.64 14.68 19 68572 1397 29504539
Medication error 17.61 14.68 14 68577 21197 29484739
Metastases to bone marrow 17.60 14.68 12 68579 470 29505466
5q minus syndrome 17.59 14.68 8 68583 139 29505797
Retinal pigment epitheliopathy 17.58 14.68 9 68582 205 29505731
Benign prostatic hyperplasia 17.55 14.68 3 68588 11707 29494229
Mucoepidermoid carcinoma 17.55 14.68 5 68586 19 29505917
Pneumomediastinum 17.52 14.68 21 68570 1735 29504201
Musculoskeletal pain 17.46 14.68 25 68566 28928 29477008
Psychotic disorder 17.45 14.68 13 68578 20341 29485595
Vertigo 17.44 14.68 15 68576 21846 29484090
Disorder of orbit 17.43 14.68 7 68584 88 29505848
Pneumonia cytomegaloviral 17.41 14.68 26 68565 2656 29503280
Acute myeloid leukaemia recurrent 17.29 14.68 21 68570 1759 29504177
Agitation 17.26 14.68 61 68530 51243 29454693
Hyperlipidaemia 17.25 14.68 4 68587 12586 29493350
Guillain-Barre syndrome 17.24 14.68 37 68554 5021 29500915
Cardiomyopathy 17.22 14.68 74 68517 14713 29491223
Prostatic specific antigen increased 17.20 14.68 4 68587 12560 29493376
Hepatic cirrhosis 17.19 14.68 6 68585 14438 29491498
Varicella zoster virus infection 17.07 14.68 19 68572 1449 29504487
Renal infarct 17.07 14.68 17 68574 1140 29504796
Alpha haemolytic streptococcal infection 17.05 14.68 15 68576 859 29505077
Granulocyte count decreased 16.99 14.68 13 68578 611 29505325
Adenomatous polyposis coli 16.99 14.68 8 68583 151 29505785
Product administration error 16.93 14.68 6 68585 14304 29491632
Coronary artery thrombosis 16.84 14.68 22 68569 1983 29503953
CNS ventriculitis 16.82 14.68 9 68582 225 29505711
Paraesthesia 16.82 14.68 66 68525 53779 29452157
Lethargy 16.81 14.68 39 68552 37541 29468395
Cerebral venous thrombosis 16.73 14.68 13 68578 625 29505311
Gait inability 16.73 14.68 11 68580 18364 29487572
Pneumothorax 16.73 14.68 77 68514 15765 29490171
Fanconi syndrome acquired 16.72 14.68 21 68570 1821 29504115
Acanthamoeba infection 16.69 14.68 11 68580 407 29505529
Recall phenomenon 16.47 14.68 12 68579 523 29505413
Poikiloderma 16.43 14.68 8 68583 163 29505773
Hypoaesthesia 16.41 14.68 66 68525 53401 29452535
Superior vena cava syndrome 16.35 14.68 12 68579 529 29505407
Renal disorder 16.28 14.68 17 68574 22578 29483358
Burns first degree 16.25 14.68 4 68587 7 29505929
Atypical teratoid/rhabdoid tumour of CNS 16.25 14.68 4 68587 7 29505929
Skin laceration 16.22 14.68 3 68588 11059 29494877
Dyspnoea exertional 16.22 14.68 38 68553 36452 29469484
Blood glucose decreased 16.21 14.68 4 68587 12065 29493871
Blood culture positive 16.20 14.68 34 68557 4543 29501393
Testicular germ cell cancer metastatic 16.17 14.68 6 68585 60 29505876
Neuroendocrine tumour of the lung metastatic 16.14 14.68 7 68584 108 29505828
Pancreatitis 16.11 14.68 35 68556 34479 29471457
Chemotherapy 16.10 14.68 12 68579 542 29505394
Expanded disability status scale score increased 16.09 14.68 9 68582 246 29505690
Terminal ileitis 16.08 14.68 7 68584 109 29505827
Blindness cortical 16.06 14.68 10 68581 335 29505601
Blood pressure decreased 16.02 14.68 53 68538 45424 29460512
Bacillus bacteraemia 15.99 14.68 6 68585 62 29505874
Delayed engraftment 15.97 14.68 7 68584 111 29505825
Chronic myelomonocytic leukaemia 15.96 14.68 12 68579 549 29505387
Pulmonary fibrosis 15.91 14.68 75 68516 15507 29490429
Clostridium test positive 15.91 14.68 22 68569 2095 29503841
Procalcitonin decreased 15.90 14.68 4 68587 8 29505928
Choriocarcinoma 15.90 14.68 4 68587 8 29505928
Pleuritic pain 15.85 14.68 26 68565 2879 29503057
Congenital hepatobiliary anomaly 15.83 14.68 5 68586 29 29505907
Blastic plasmacytoid dendritic cell neoplasia 15.82 14.68 6 68585 64 29505872
Hypokalaemia 15.76 14.68 182 68409 50021 29455915
Platelet transfusion 15.76 14.68 16 68575 1098 29504838
Hirsutism 15.75 14.68 8 68583 179 29505757
Primitive neuroectodermal tumour 15.74 14.68 6 68585 65 29505871
Cerebral artery occlusion 15.70 14.68 13 68578 685 29505251
Lower respiratory tract infection fungal 15.63 14.68 12 68579 567 29505369
Pulmonary alveolar haemorrhage 15.59 14.68 41 68550 6339 29499597
Mediastinum neoplasm 15.58 14.68 4 68587 9 29505927
Gout 15.56 14.68 10 68581 16901 29489035
Adverse event 15.56 14.68 8 68583 15283 29490653
Cytokine release syndrome 15.54 14.68 66 68525 13053 29492883
Tooth hypoplasia 15.53 14.68 7 68584 119 29505817
Human herpesvirus 8 infection 15.46 14.68 14 68577 833 29505103
Subcutaneous emphysema 15.42 14.68 15 68576 977 29504959
Bone sarcoma 15.34 14.68 6 68585 70 29505866
Ewing's sarcoma recurrent 15.29 14.68 4 68587 10 29505926
Mucosal toxicity 15.28 14.68 8 68583 191 29505745
Clostridium difficile infection 15.26 14.68 76 68515 16065 29489871
Ischaemic cerebral infarction 15.26 14.68 15 68576 990 29504946
Platelet count abnormal 15.24 14.68 23 68568 2371 29503565
Erythema ab igne 15.21 14.68 3 68588 0 29505936
Li-Fraumeni syndrome 15.21 14.68 3 68588 0 29505936
Abdominal distension 15.17 14.68 55 68536 45856 29460080
Salivary gland cancer stage IV 15.15 14.68 5 68586 34 29505902
Clostridium colitis 15.14 14.68 16 68575 1151 29504785
Primary hypogonadism 15.12 14.68 6 68585 73 29505863
Hip fracture 15.06 14.68 3 68588 10489 29495447
Hepatitis D 15.03 14.68 5 68586 35 29505901
Fibrinous bronchitis 15.01 14.68 4 68587 11 29505925
Staphylococcal sepsis 15.01 14.68 50 68541 8812 29497124
Infected neoplasm 14.97 14.68 6 68585 75 29505861
Sudden death 14.93 14.68 7 68584 14103 29491833
Oesophagitis 14.92 14.68 61 68530 11862 29494074
Pleural effusion 14.91 14.68 242 68349 71666 29434270
Respiratory arrest 14.90 14.68 23 68568 25810 29480126
Iris atrophy 14.90 14.68 6 68585 76 29505860
Stevens-Johnson syndrome 14.85 14.68 10 68581 16487 29489449
Cerebral artery stenosis 14.85 14.68 9 68582 287 29505649
Ill-defined disorder 14.82 14.68 60 68531 11618 29494318
Gene mutation 14.82 14.68 15 68576 1026 29504910
Pelvic mass 14.81 14.68 8 68583 204 29505732
Thyroid cancer 14.77 14.68 17 68574 1345 29504591
Swollen tongue 14.76 14.68 5 68586 12261 29493675
JC virus infection 14.69 14.68 20 68571 1877 29504059

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 4869.79 14.05 3325 104887 184332 64206188
Neutropenia 1745.56 14.05 2075 106137 237549 64152971
Mucosal inflammation 1299.57 14.05 972 107240 61612 64328908
Pancytopenia 1299.02 14.05 1392 106820 141917 64248603
Bone marrow failure 1296.63 14.05 875 107337 47077 64343443
Acute myeloid leukaemia 1026.25 14.05 615 107597 26848 64363672
Product use in unapproved indication 1001.71 14.05 1352 106860 175266 64215254
Thrombocytopenia 999.64 14.05 1529 106683 222272 64168248
Myelodysplastic syndrome 941.74 14.05 583 107629 26996 64363524
Off label use 706.39 14.05 2493 105719 630313 63760207
Venoocclusive liver disease 687.79 14.05 336 107876 9679 64380841
Myelosuppression 680.14 14.05 450 107762 23380 64367140
Haematotoxicity 665.96 14.05 357 107855 12539 64377981
Second primary malignancy 602.16 14.05 329 107883 12008 64378512
Malignant neoplasm progression 561.28 14.05 812 107400 112059 64278461
Sepsis 542.38 14.05 1194 107018 229147 64161373
Disease progression 525.98 14.05 891 107321 140789 64249731
Febrile bone marrow aplasia 467.42 14.05 270 107942 10985 64379535
Tumour lysis syndrome 462.12 14.05 328 107884 19112 64371408
Septic shock 446.56 14.05 704 107508 104733 64285787
Neutropenic sepsis 433.14 14.05 339 107873 22933 64367587
Neutrophil count decreased 420.01 14.05 580 107632 76616 64313904
Haemophagocytic lymphohistiocytosis 402.22 14.05 290 107922 17319 64373201
Pain 359.37 14.05 245 107967 553266 63837254
Fall 358.91 14.05 126 108086 416700 63973820
Arthralgia 347.45 14.05 154 108058 442106 63948414
Posterior reversible encephalopathy syndrome 346.58 14.05 296 107916 22650 64367870
Stem cell transplant 346.07 14.05 151 108061 3330 64387190
Aplasia 329.82 14.05 182 108030 6771 64383749
Joint swelling 327.33 14.05 7 108205 215375 64175145
Multiple organ dysfunction syndrome 322.13 14.05 596 107616 100817 64289703
Leukopenia 301.69 14.05 579 107633 100663 64289857
Diffuse large B-cell lymphoma recurrent 301.51 14.05 133 108079 3013 64387507
Pyrexia 290.05 14.05 1761 106451 556883 63833637
Peripheral swelling 274.12 14.05 20 108192 209133 64181387
Aspergillus infection 265.29 14.05 220 107992 16159 64374361
Malignant transformation 258.49 14.05 90 108122 1051 64389469
Encephalopathy 254.73 14.05 397 107815 58422 64332098
Anaemia 247.55 14.05 1271 106941 377409 64013111
Product dose omission issue 243.13 14.05 23 108189 194724 64195796
Bronchopulmonary aspergillosis 240.05 14.05 222 107990 18863 64371657
Venoocclusive disease 233.25 14.05 120 108092 3865 64386655
Cytopenia 226.34 14.05 196 108016 15275 64375245
Fatigue 224.67 14.05 587 107625 748143 63642377
Cardiotoxicity 222.80 14.05 164 108048 10110 64380410
Nasopharyngitis 220.48 14.05 33 108179 196040 64194480
Rheumatoid arthritis 220.24 14.05 14 108198 164280 64226240
Bacteraemia 218.09 14.05 247 107965 26664 64363856
Dizziness 211.99 14.05 246 107966 429917 63960603
Neoplasm progression 211.07 14.05 300 107912 40664 64349856
Cytomegalovirus infection 210.49 14.05 285 107927 36914 64353606
Drug hypersensitivity 204.20 14.05 72 108140 237743 64152777
Acute graft versus host disease 203.76 14.05 148 108064 8936 64381584
Platelet count decreased 201.26 14.05 679 107533 167032 64223488
Neutropenic colitis 201.18 14.05 114 108098 4467 64386053
Malaise 199.12 14.05 223 107989 396024 63994496
Headache 196.39 14.05 369 107843 529098 63861422
Cystitis haemorrhagic 190.79 14.05 135 108077 7821 64382699
Cytogenetic abnormality 189.28 14.05 70 108142 984 64389536
Pruritus 188.37 14.05 149 108063 312251 64078269
Therapy partial responder 187.87 14.05 148 108064 10100 64380420
Insomnia 185.76 14.05 51 108161 197785 64192735
Weight increased 180.75 14.05 66 108146 213282 64177238
Abdominal discomfort 178.84 14.05 43 108169 182279 64208241
Overdose 176.76 14.05 28 108184 159538 64230982
Respiratory failure 176.39 14.05 633 107579 160550 64229970
Drug abuse 175.28 14.05 12 108200 132362 64258158
Musculoskeletal stiffness 172.88 14.05 8 108204 123198 64267322
Secondary immunodeficiency 170.99 14.05 86 108126 2638 64387882
Rash 170.45 14.05 319 107893 458230 63932290
Arthropathy 169.26 14.05 8 108204 120959 64269561
Bacterial infection 169.06 14.05 209 108003 24741 64365779
Injection site pain 167.69 14.05 4 108208 111404 64279116
Drug resistance 167.61 14.05 248 107964 34854 64355666
Diffuse large B-cell lymphoma refractory 167.01 14.05 65 108147 1059 64389461
Disease recurrence 153.88 14.05 225 107987 31285 64359235
Neurotoxicity 152.05 14.05 208 108004 27196 64363324
Pain in extremity 151.67 14.05 171 108041 302914 64087606
Ototoxicity 150.77 14.05 79 108133 2644 64387876
Anxiety 148.96 14.05 77 108135 202572 64187948
Blood pressure increased 145.08 14.05 54 108158 172498 64218022
Clostridium difficile colitis 141.15 14.05 200 108012 27023 64363497
Cytomegalovirus chorioretinitis 140.66 14.05 93 108119 4819 64385701
Human herpesvirus 6 infection 140.31 14.05 91 108121 4563 64385957
Colitis 139.69 14.05 306 107906 58368 64332152
Swelling 138.34 14.05 48 108164 160170 64230350
Teratoma 137.75 14.05 35 108177 116 64390404
Nephropathy toxic 137.24 14.05 158 108054 17356 64373164
Fungal infection 136.98 14.05 223 107989 34028 64356492
Graft versus host disease 133.24 14.05 139 108073 13674 64376846
Neoplasm recurrence 132.51 14.05 81 108131 3658 64386862
White blood cell count decreased 131.45 14.05 569 107643 157268 64233252
Candida infection 130.34 14.05 208 108004 31211 64359309
Renal salt-wasting syndrome 126.29 14.05 42 108170 422 64390098
Enterococcal infection 125.70 14.05 135 108077 13731 64376789
BK virus infection 125.12 14.05 102 108110 7310 64383210
Cytomegalovirus viraemia 122.88 14.05 119 108093 10709 64379811
Lymphopenia 120.66 14.05 180 108032 25477 64365043
Hepatitis B reactivation 119.65 14.05 84 108128 4805 64385715
Asthma 119.43 14.05 11 108201 95214 64295306
Feeling abnormal 117.11 14.05 39 108173 133563 64256957
Neuropathy peripheral 116.32 14.05 447 107765 117078 64273442
Muscle spasms 115.43 14.05 46 108166 140977 64249543
Sweat gland tumour 114.73 14.05 40 108172 469 64390051
Pneumocystis jirovecii pneumonia 111.97 14.05 181 108031 27453 64363067
Staphylococcal bacteraemia 110.43 14.05 110 108102 10245 64380275
Mycobacterium chelonae infection 109.84 14.05 59 108153 2078 64388442
Contraindicated product administered 106.54 14.05 25 108187 107804 64282716
Ovarian germ cell teratoma 106.45 14.05 25 108187 53 64390467
Renal tubular disorder 104.47 14.05 84 108128 5903 64384617
Primary hypogonadism 104.16 14.05 29 108183 148 64390372
Wound 104.00 14.05 6 108206 76471 64314049
Contusion 103.92 14.05 31 108181 113934 64276586
Epstein-Barr virus infection 103.51 14.05 116 108096 12372 64378148
Acute promyelocytic leukaemia 102.62 14.05 49 108163 1339 64389181
Urticaria 102.38 14.05 60 108152 147257 64243263
Thrombotic microangiopathy 100.94 14.05 132 108080 16523 64373997
Inappropriate schedule of product administration 100.36 14.05 17 108195 92269 64298251
Progressive multifocal leukoencephalopathy 96.07 14.05 135 108077 18097 64372423
Pseudomonal sepsis 95.46 14.05 75 108137 5097 64385423
Parainfluenzae virus infection 94.56 14.05 72 108140 4671 64385849
Suicidal ideation 94.38 14.05 4 108208 66538 64323982
Stomatitis 93.41 14.05 398 107814 109207 64281313
Depression 93.15 14.05 102 108110 183189 64207331
Chronic graft versus host disease 92.78 14.05 80 108132 6196 64384324
Therapeutic product effect decreased 92.17 14.05 39 108173 115312 64275208
Arthritis 92.12 14.05 15 108197 83799 64306721
Somnolence 91.19 14.05 125 108087 203520 64187000
Injection site erythema 89.26 14.05 8 108204 70792 64319728
Pulmonary haemorrhage 89.10 14.05 110 108102 12999 64377521
Osteosarcoma 88.50 14.05 29 108183 277 64390243
Bronchitis 88.12 14.05 36 108176 108707 64281813
Stress 88.04 14.05 3 108209 60531 64329989
Klebsiella sepsis 85.63 14.05 54 108158 2578 64387942
Discomfort 85.55 14.05 16 108196 80862 64309658
Chloroma 84.75 14.05 35 108177 670 64389850
Oedema peripheral 84.58 14.05 139 108073 210178 64180342
Hepatitis B 83.93 14.05 83 108129 7662 64382858
Psoriasis 83.04 14.05 11 108201 71692 64318828
Drug interaction 82.75 14.05 320 107892 361763 64028757
Tremor 82.73 14.05 76 108136 148154 64242366
Acute respiratory distress syndrome 81.49 14.05 193 108019 38742 64351778
Oesophagitis 81.33 14.05 137 108075 21493 64369027
Adenovirus infection 80.95 14.05 79 108133 7176 64383344
Myalgia 80.88 14.05 88 108124 158529 64231991
Anaplastic lymphoma kinase gene mutation 80.75 14.05 22 108190 102 64390418
Pulmonary toxicity 80.52 14.05 85 108127 8476 64382044
Influenza like illness 80.48 14.05 6 108206 61696 64328824
Teratoma benign 79.97 14.05 20 108192 61 64390459
Urinary tract infection 79.92 14.05 168 108044 231428 64159092
Gait disturbance 79.79 14.05 103 108109 172052 64218468
Epstein-Barr virus associated lymphoproliferative disorder 79.63 14.05 55 108157 3064 64387456
Loss of personal independence in daily activities 79.55 14.05 13 108199 72441 64318079
Suicide attempt 77.39 14.05 13 108199 70994 64319526
Acute graft versus host disease in skin 77.15 14.05 75 108137 6780 64383740
Peripheral sensory neuropathy 76.57 14.05 95 108117 11283 64379237
Disseminated intravascular coagulation 76.17 14.05 168 108044 32180 64358340
Oesophageal candidiasis 76.11 14.05 80 108132 7937 64382583
Drug intolerance 75.81 14.05 124 108088 187868 64202652
Alveolar soft part sarcoma 75.79 14.05 20 108192 80 64390440
Klebsiella infection 75.47 14.05 102 108110 13179 64377341
Diffuse large B-cell lymphoma 75.40 14.05 90 108122 10271 64380249
Weight decreased 75.01 14.05 238 107974 285501 64105019
Systemic candida 74.89 14.05 66 108146 5263 64385257
Fungaemia 74.45 14.05 57 108155 3728 64386792
Blood pressure fluctuation 73.96 14.05 3 108209 51868 64338652
Bacterial sepsis 73.64 14.05 76 108136 7381 64383139
Gene mutation 73.52 14.05 45 108167 2037 64388483
Acute lymphocytic leukaemia 71.37 14.05 59 108153 4312 64386208
Enterococcal bacteraemia 70.69 14.05 47 108165 2458 64388062
Recurrent cancer 70.55 14.05 46 108166 2327 64388193
Chest pain 70.36 14.05 185 108027 235795 64154725
Capillary leak syndrome 70.06 14.05 52 108160 3245 64387275
Abdominal pain upper 70.06 14.05 116 108096 174914 64215606
Blood glucose increased 69.47 14.05 39 108173 98034 64292486
Migraine 69.36 14.05 11 108201 62666 64327854
Pulmonary vascular disorder 69.30 14.05 33 108179 896 64389624
Hypoglycaemia 69.27 14.05 32 108180 89860 64300660
Injury 68.80 14.05 7 108205 55985 64334535
Hospitalisation 67.57 14.05 21 108191 75186 64315334
Human bocavirus infection 67.47 14.05 28 108184 543 64389977
Leukaemia recurrent 66.83 14.05 46 108166 2548 64387972
Incorrect dose administered 66.49 14.05 11 108201 60754 64329766
Myeloid leukaemia 65.77 14.05 28 108184 580 64389940
Hypersensitivity 65.69 14.05 145 108067 196307 64194213
Leukoencephalopathy 65.21 14.05 69 108143 6898 64383622
Graft versus host disease in skin 64.91 14.05 61 108151 5286 64385234
Complications of bone marrow transplant 64.60 14.05 28 108184 607 64389913
Streptococcal bacteraemia 64.34 14.05 48 108164 3019 64387501
Systemic mycosis 64.14 14.05 43 108169 2280 64388240
Metastasis 63.51 14.05 62 108150 5633 64384887
Refractory anaemia with an excess of blasts 62.95 14.05 30 108182 816 64389704
Acute lymphocytic leukaemia recurrent 62.95 14.05 53 108159 3973 64386547
Staphylococcal infection 62.28 14.05 207 108005 50471 64340049
Memory impairment 62.25 14.05 33 108179 85649 64304871
Pneumonitis 62.14 14.05 206 108006 50159 64340361
Pleural effusion 62.06 14.05 394 107818 126165 64264355
Dyspnoea 62.02 14.05 842 107370 717832 63672688
Ovarian failure 61.96 14.05 26 108186 519 64390001
Aplastic anaemia 61.67 14.05 95 108117 13825 64376695
Post transplant lymphoproliferative disorder 61.53 14.05 78 108134 9466 64381054
Herpes simplex 61.52 14.05 82 108130 10454 64380066
Enteritis 61.52 14.05 88 108124 11989 64378531
Vision blurred 61.03 14.05 38 108174 90278 64300242
Hepatic enzyme increased 60.97 14.05 77 108135 129866 64260654
Myocardial infarction 60.85 14.05 116 108096 165705 64224815
Fusarium infection 60.80 14.05 36 108176 1533 64388987
Hepatosplenic T-cell lymphoma 60.71 14.05 29 108183 793 64389727
Mucormycosis 60.51 14.05 68 108144 7273 64383247
Pneumothorax 60.41 14.05 129 108083 24169 64366351
Glossodynia 60.07 14.05 17 108195 64679 64325841
Agranulocytosis 59.90 14.05 170 108042 38059 64352461
Back pain 59.76 14.05 217 107995 249954 64140566
Coronary artery disease 59.71 14.05 14 108198 60419 64330101
Cardiac failure congestive 59.59 14.05 79 108133 130501 64260019
Musculoskeletal pain 59.51 14.05 31 108181 81263 64309257
Salivary gland cancer 59.02 14.05 23 108189 376 64390144
Nasal congestion 58.59 14.05 14 108198 59644 64330876
Hypokalaemia 58.22 14.05 377 107835 121526 64268994
Condition aggravated 57.64 14.05 377 107835 372049 64018471
Lymphadenopathy 57.64 14.05 191 108021 46495 64344025
Viral haemorrhagic cystitis 56.87 14.05 35 108177 1600 64388920
Pneumonia klebsiella 56.74 14.05 50 108162 3987 64386533
Palpitations 56.62 14.05 55 108157 104433 64286087
Depressed mood 56.43 14.05 3 108209 41009 64349511
Blood pressure systolic increased 56.28 14.05 8 108204 49445 64341075
Hyperkalaemia 56.24 14.05 52 108160 101077 64289443
Superior vena cava syndrome 56.15 14.05 30 108182 1045 64389475
Pulmonary arteriopathy 55.88 14.05 16 108196 92 64390428
Thymus hypoplasia 55.85 14.05 24 108188 509 64390011
Balance disorder 55.76 14.05 36 108176 83890 64306630
Hyperhidrosis 55.56 14.05 77 108135 124843 64265677
Hypogammaglobulinaemia 55.36 14.05 77 108135 10222 64380298
Acute myeloid leukaemia recurrent 54.92 14.05 42 108170 2742 64387778
Blood cholesterol increased 54.92 14.05 9 108203 50057 64340463
B-cell lymphoma recurrent 54.38 14.05 27 108185 805 64389715
Ameloblastoma 53.49 14.05 15 108197 79 64390441
Loss of consciousness 53.38 14.05 105 108107 148260 64242260
Wheezing 52.94 14.05 35 108177 80544 64309976
Sinusitis 52.74 14.05 103 108109 145825 64244695
Blood stem cell transplant failure 52.50 14.05 23 108189 512 64390008
Rhabdomyolysis 52.40 14.05 46 108166 91680 64298840
Enterobacter infection 52.39 14.05 46 108166 3650 64386870
Cardiomyopathy 52.30 14.05 125 108087 25231 64365289
Premature menopause 52.13 14.05 23 108189 521 64389999
Pneumonia fungal 51.70 14.05 69 108143 8808 64381712
Psoriatic arthropathy 51.67 14.05 6 108206 43275 64347245
Cerebrovascular accident 51.57 14.05 95 108117 137488 64253032
Injection site pruritus 51.32 14.05 3 108209 37823 64352697
Sleep disorder 51.31 14.05 18 108194 59691 64330829
Metastases to lung 51.28 14.05 92 108120 15172 64375348
Refractory cancer 51.10 14.05 18 108194 218 64390302
Gastrooesophageal reflux disease 50.84 14.05 39 108173 83104 64307416
Metastases to central nervous system 50.83 14.05 87 108125 13825 64376695
Device related infection 50.75 14.05 139 108073 30487 64360033
Dry mouth 50.59 14.05 19 108193 60399 64330121
Paraneoplastic neurological syndrome 50.51 14.05 13 108199 46 64390474
Varicella zoster virus infection 50.38 14.05 46 108166 3842 64386678
Medulloblastoma recurrent 50.37 14.05 15 108197 101 64390419
Gastrointestinal toxicity 50.33 14.05 53 108159 5269 64385251
Mobility decreased 50.31 14.05 42 108170 85798 64304722
Retinal haemorrhage 50.15 14.05 62 108150 7336 64383184
Nephrolithiasis 49.87 14.05 7 108205 43676 64346844
Trichosporon infection 49.73 14.05 26 108186 866 64389654
Escherichia bacteraemia 49.67 14.05 53 108159 5350 64385170
Blister 49.48 14.05 38 108174 80929 64309591
Pneumatosis intestinalis 49.32 14.05 52 108160 5177 64385343
T-cell type acute leukaemia 49.29 14.05 16 108196 148 64390372
Chronic obstructive pulmonary disease 49.25 14.05 29 108183 71019 64319501
Aortic thrombosis 49.10 14.05 31 108181 1483 64389037
Deafness 48.58 14.05 100 108112 18259 64372261
Rash pruritic 48.15 14.05 18 108194 57386 64333134
Metastases to lymph nodes 48.10 14.05 66 108146 8651 64381869
Pseudomonas infection 48.02 14.05 98 108114 17785 64372735
Lymphoid tissue hypoplasia 47.83 14.05 21 108191 470 64390050
Angioedema 47.64 14.05 22 108190 61799 64328721
Impaired healing 47.41 14.05 21 108191 60452 64330068
Large intestinal ulcer perforation 47.08 14.05 13 108199 64 64390456
Therapy non-responder 46.92 14.05 227 107985 65672 64324848
Osteonecrosis 46.65 14.05 128 108084 28101 64362419
Hepatosplenomegaly 46.64 14.05 51 108161 5292 64385228
Heart rate decreased 46.64 14.05 17 108195 55050 64335470
Sedation 46.51 14.05 7 108205 41455 64349065
Electrocardiogram QT prolonged 46.40 14.05 39 108173 79409 64311111
Delayed puberty 46.18 14.05 15 108197 139 64390381
Renal failure 46.15 14.05 487 107725 181201 64209319
Myelopathy 45.70 14.05 44 108168 3930 64386590
Vertigo 45.47 14.05 21 108191 58990 64331530
Embolism 45.34 14.05 77 108135 12158 64378362
Aggression 45.10 14.05 11 108201 46221 64344299
Stenotrophomonas infection 45.00 14.05 39 108173 3041 64387479
Mesenteric abscess 44.59 14.05 14 108198 115 64390405
Wrong technique in product usage process 44.36 14.05 27 108185 64947 64325573
Drug dependence 44.13 14.05 3 108209 33309 64357211
Nail pigmentation 43.23 14.05 17 108195 285 64390235
Subdural hygroma 42.72 14.05 19 108193 439 64390081
Hypomagnesaemia 42.70 14.05 149 108063 37227 64353293
Burning sensation 42.63 14.05 15 108197 49649 64340871
Blood culture positive 42.55 14.05 59 108153 7809 64382711
Gastrointestinal fungal infection 42.41 14.05 18 108194 370 64390150
Toxic encephalopathy 42.11 14.05 66 108146 9749 64380771
Leukaemia 41.72 14.05 47 108165 5041 64385479
Metastases to bone marrow 41.66 14.05 21 108191 647 64389873
Nervous system disorder 41.53 14.05 108 108104 22970 64367550
Bicytopenia 41.46 14.05 40 108172 3582 64386938
Ejection fraction decreased 41.46 14.05 124 108088 28583 64361937
Encephalitis cytomegalovirus 41.42 14.05 24 108188 981 64389539
Lactic acidosis 41.26 14.05 26 108186 61384 64329136
Klebsiella bacteraemia 41.18 14.05 33 108179 2307 64388213
Metastases to spleen 40.91 14.05 19 108193 487 64390033
Diaphragm muscle weakness 40.48 14.05 14 108198 160 64390360
Cytomegalovirus infection reactivation 40.25 14.05 49 108163 5707 64384813
JC virus infection 40.20 14.05 38 108174 3317 64387203
Myelitis 39.76 14.05 31 108181 2083 64388437
Cardiomyopathy acute 39.55 14.05 15 108197 227 64390293
Haematochezia 39.48 14.05 32 108180 66341 64324179
Abscess bacterial 39.08 14.05 21 108191 740 64389780
Rhabdomyosarcoma recurrent 39.06 14.05 12 108200 91 64390429
Streptococcal infection 38.83 14.05 55 108157 7424 64383096
Plasma cell leukaemia 38.74 14.05 27 108185 1526 64388994
Influenza 38.65 14.05 75 108137 106456 64284064
Adverse drug reaction 38.56 14.05 14 108198 45450 64345070
Hypoaesthesia 38.49 14.05 113 108099 138995 64251525
Cytokine release syndrome 38.02 14.05 98 108114 20731 64369789
Hyperbilirubinaemia 37.92 14.05 99 108113 21106 64369414
Blood creatine phosphokinase increased 37.71 14.05 26 108186 58532 64331988
Road traffic accident 37.37 14.05 4 108208 30741 64359779
Peripheral T-cell lymphoma unspecified 37.32 14.05 19 108193 598 64389922
Flagellate dermatitis 37.27 14.05 14 108198 206 64390314
Fanconi syndrome 37.21 14.05 32 108180 2469 64388051
Acquired gene mutation 37.08 14.05 29 108183 1957 64388563
Hepatotoxicity 37.06 14.05 149 108063 39813 64350707
Serotonin syndrome 37.06 14.05 10 108202 39272 64351248
Blood lactate dehydrogenase increased 37.04 14.05 131 108081 32947 64357573
Pulmonary alveolar haemorrhage 37.03 14.05 62 108150 9676 64380844
International normalised ratio increased 37.03 14.05 47 108165 79120 64311400
Neuroblastoma 37.01 14.05 13 108199 156 64390364
Clostridium colitis 36.95 14.05 32 108180 2493 64388027
Acute myelomonocytic leukaemia 36.92 14.05 15 108197 275 64390245
Viraemia 36.88 14.05 31 108181 2318 64388202
Lung infiltration 36.81 14.05 97 108115 20792 64369728
Swollen tongue 36.78 14.05 7 108205 34947 64355573
Radiation pneumonitis 36.68 14.05 36 108176 3292 64387228
Hallucination 36.40 14.05 41 108171 72747 64317773
Respiratory distress 36.35 14.05 179 108033 52152 64338368
Focal nodular hyperplasia 36.20 14.05 19 108193 638 64389882
Extravasation 36.18 14.05 35 108177 3145 64387375
Metastases to liver 36.08 14.05 105 108107 23836 64366684
Osteonecrosis of jaw 35.99 14.05 11 108201 39814 64350706
Radiation oesophagitis 35.76 14.05 18 108194 553 64389967
Lower respiratory tract infection 35.74 14.05 65 108147 94549 64295971
Ganglioneuroblastoma 35.61 14.05 9 108203 29 64390491
Small cell lung cancer 35.50 14.05 32 108180 2629 64387891
Fungal oesophagitis 35.40 14.05 20 108192 779 64389741
Heart rate increased 35.34 14.05 70 108142 98605 64291915
Therapy cessation 35.28 14.05 6 108206 32483 64358037
Epstein Barr virus positive mucocutaneous ulcer 35.14 14.05 19 108193 678 64389842
Vena cava thrombosis 35.08 14.05 31 108181 2481 64388039
Staphylococcal sepsis 35.01 14.05 71 108141 12828 64377692
Diabetes mellitus 34.85 14.05 36 108176 66438 64324082
Venous thrombosis 34.73 14.05 48 108164 6333 64384187
Encephalitis viral 34.50 14.05 30 108182 2350 64388170
Amnesia 34.45 14.05 19 108193 48250 64342270
Chronic myeloid leukaemia 34.43 14.05 35 108177 3339 64387181
Skin candida 34.27 14.05 26 108186 1677 64388843
Engraftment syndrome 34.13 14.05 22 108190 1091 64389429
Fluid retention 33.91 14.05 30 108182 59576 64330944
Adrenocortical carcinoma 33.88 14.05 10 108202 65 64390455
Traumatic lung injury 33.62 14.05 29 108183 2247 64388273
Bone marrow transplant 33.57 14.05 23 108189 1264 64389256
Femur fracture 33.53 14.05 8 108204 34127 64356393
Exposure during pregnancy 33.42 14.05 49 108163 77626 64312894
Cutaneous calcification 33.39 14.05 11 108201 107 64390413
Retinopathy proliferative 33.39 14.05 11 108201 107 64390413
Epstein-Barr virus infection reactivation 33.20 14.05 22 108190 1144 64389376
Unevaluable event 33.07 14.05 22 108190 50467 64340053
Necrotising gastritis 32.76 14.05 10 108202 74 64390446
T-cell lymphoma 32.69 14.05 22 108190 1174 64389346
Hepatic candidiasis 32.53 14.05 10 108202 76 64390444
Peripheral motor neuropathy 32.50 14.05 32 108180 2938 64387582
Emotional distress 32.48 14.05 10 108202 36028 64354492
Respiratory arrest 32.20 14.05 25 108187 52960 64337560
Faeces discoloured 32.18 14.05 3 108209 25726 64364794
Graft versus host disease in liver 32.06 14.05 24 108188 1517 64389003
Diffuse alveolar damage 32.00 14.05 33 108179 3202 64387318
Eosinophilia 31.83 14.05 12 108200 38064 64352456
Graft versus host disease in gastrointestinal tract 31.73 14.05 43 108169 5569 64384951
Encephalitis 31.54 14.05 67 108145 12504 64378016
Lower respiratory tract infection fungal 31.53 14.05 19 108193 836 64389684
Cystitis bacterial 31.48 14.05 15 108197 408 64390112
Enterocolitis 31.26 14.05 65 108147 11953 64378567
Drug reaction with eosinophilia and systemic symptoms 31.19 14.05 27 108185 54190 64336330
Recall phenomenon 31.14 14.05 20 108192 986 64389534
Confusional state 31.12 14.05 284 107928 260860 64129660
Azoospermia 30.88 14.05 11 108201 138 64390382
Accidental overdose 30.81 14.05 9 108203 33548 64356972
Choriocarcinoma 30.69 14.05 9 108203 57 64390463
Encephalitis enteroviral 30.59 14.05 11 108201 142 64390378
Pneumonia 30.53 14.05 1187 107025 558389 63832131
Escherichia infection 30.45 14.05 74 108138 15094 64375426
Nasal abscess 30.25 14.05 11 108201 147 64390373
Retinal pigment epitheliopathy 30.06 14.05 14 108198 361 64390159
Hypoalbuminaemia 30.06 14.05 81 108131 17593 64372927
Paraesthesia 29.94 14.05 120 108092 134402 64256118
Injection site haemorrhage 29.91 14.05 3 108209 24275 64366245
Iris atrophy 29.59 14.05 10 108202 106 64390414
Mantle cell lymphoma recurrent 29.38 14.05 15 108197 475 64390045
Diabetic ketoacidosis 29.31 14.05 7 108205 29838 64360682
Sopor 29.04 14.05 7 108205 29654 64360866
Intestinal perforation 28.94 14.05 73 108139 15240 64375280
Blood electrolytes abnormal 28.88 14.05 24 108188 1767 64388753
Plasmacytoma 28.79 14.05 34 108178 3836 64386684
Listeria sepsis 28.75 14.05 16 108196 605 64389915
Metastases to muscle 28.74 14.05 13 108199 313 64390207
Hypophosphataemia 28.68 14.05 71 108141 14649 64375871
Leukoerythroblastosis 28.48 14.05 12 108200 242 64390278
Metastases to diaphragm 28.39 14.05 8 108204 43 64390477
Injection site reaction 28.38 14.05 22 108190 46642 64343878
Neck pain 28.29 14.05 37 108175 61496 64329024
Hepatic cirrhosis 28.24 14.05 5 108207 26293 64364227
Disturbance in attention 28.13 14.05 17 108195 41057 64349463
Blood glucose decreased 28.12 14.05 3 108209 23120 64367400
Acne 28.06 14.05 3 108209 23078 64367442
Head injury 28.04 14.05 10 108202 32832 64357688
Toxicity to various agents 28.03 14.05 435 107777 363078 64027442
Cardio-respiratory arrest 27.89 14.05 79 108133 98314 64292206
Localised infection 27.85 14.05 8 108204 30153 64360367
Geotrichum infection 27.79 14.05 18 108194 900 64389620
Escherichia sepsis 27.76 14.05 46 108166 7119 64383401
Norovirus test positive 27.61 14.05 14 108198 437 64390083
Alpha haemolytic streptococcal infection 27.57 14.05 23 108189 1702 64388818
Red blood cell sedimentation rate increased 27.56 14.05 9 108203 31226 64359294
Underdose 27.54 14.05 5 108207 25824 64364696
Papillary thyroid cancer 27.48 14.05 26 108186 2272 64388248
Cellulitis gangrenous 27.36 14.05 12 108200 268 64390252
Metastases to retroperitoneum 27.06 14.05 13 108199 360 64390160
Flatulence 27.00 14.05 13 108199 35653 64354867
Pneumonia aspiration 26.88 14.05 36 108176 59235 64331285
Myelitis transverse 26.69 14.05 22 108190 1601 64388919
Tumour hyperprogression 26.63 14.05 10 108202 147 64390373
Infection 26.60 14.05 447 107765 184433 64206087
Gliosis 26.48 14.05 13 108199 378 64390142
Type 2 diabetes mellitus 26.37 14.05 12 108200 34008 64356512
Splenomegaly 26.33 14.05 78 108134 17883 64372637
Fungal sepsis 26.28 14.05 22 108190 1636 64388884
Accidental exposure to product 26.25 14.05 6 108206 26358 64364162
Li-Fraumeni syndrome 26.12 14.05 6 108206 11 64390509
Odynophagia 26.08 14.05 53 108159 9588 64380932
Lymphoma 25.86 14.05 66 108146 13875 64376645
Abdominal distension 25.81 14.05 79 108133 95915 64294605
Enterococcal sepsis 25.68 14.05 26 108186 2468 64388052
Intestinal atresia 25.67 14.05 8 108204 64 64390456
Cerebral salt-wasting syndrome 25.55 14.05 9 108203 109 64390411
Central nervous system fungal infection 25.54 14.05 13 108199 409 64390111
Cataract 25.49 14.05 29 108183 51233 64339287
Genotoxicity 25.43 14.05 7 108205 34 64390486
Transient ischaemic attack 25.42 14.05 22 108190 44160 64346360
Hip fracture 25.38 14.05 7 108205 27092 64363428
Hair follicle tumour benign 25.17 14.05 13 108199 422 64390098
Diverticulitis 25.06 14.05 17 108195 38601 64351919
Therapy responder 25.00 14.05 13 108199 428 64390092
Device issue 25.00 14.05 4 108208 22644 64367876
Dyspnoea exertional 24.96 14.05 54 108158 73676 64316844
Respiratory tract infection fungal 24.96 14.05 18 108194 1074 64389446
Electrolyte imbalance 24.93 14.05 96 108116 25147 64365373
Streptococcal sepsis 24.75 14.05 25 108187 2367 64388153
Bradycardia 24.73 14.05 108 108104 118111 64272409
Carcinoid crisis 24.65 14.05 13 108199 441 64390079
Dyspepsia 24.64 14.05 62 108150 80250 64310270
Hypoxia 24.62 14.05 241 107971 87908 64302612
Rhinovirus infection 24.49 14.05 40 108172 6116 64384404
Abortion spontaneous 24.49 14.05 6 108206 25137 64365383
Abnormal behaviour 24.34 14.05 13 108199 33609 64356911
Ewing's sarcoma recurrent 24.32 14.05 6 108206 17 64390503
Neutrophil count abnormal 24.17 14.05 27 108185 2869 64387651
Carbamoyl phosphate synthetase deficiency 24.07 14.05 6 108206 18 64390502
Medication error 24.06 14.05 29 108183 49937 64340583
Amenorrhoea 24.03 14.05 41 108171 6498 64384022
Ear infection 23.97 14.05 5 108207 23399 64367121
Viral infection 23.95 14.05 122 108090 36018 64354502
Clostridium bacteraemia 23.79 14.05 11 108201 279 64390241
Chest discomfort 23.73 14.05 107 108105 115999 64274521
Maternal exposure during pregnancy 23.64 14.05 82 108130 95802 64294718
Hypoacusis 23.63 14.05 96 108116 25771 64364749
Adverse event 23.53 14.05 19 108193 39470 64351050
Coronavirus infection 23.46 14.05 37 108175 5493 64385027
Treatment noncompliance 23.41 14.05 23 108189 43459 64347061
Hyperlipidaemia 23.34 14.05 5 108207 22971 64367549
Dry skin 23.28 14.05 31 108181 51130 64339390
Osteosarcoma metastatic 23.27 14.05 7 108205 49 64390471
Paraparesis 23.18 14.05 29 108183 3473 64387047
Throat irritation 23.17 14.05 13 108199 32698 64357822
Breast cancer 23.04 14.05 10 108202 29138 64361382
Diabetes mellitus inadequate control 23.01 14.05 4 108208 21317 64369203
Alopecia 22.99 14.05 173 108039 165517 64225003
Human herpesvirus 8 infection 22.97 14.05 17 108195 1056 64389464
Osteoporosis 22.96 14.05 22 108190 42058 64348462
Hypertension 22.87 14.05 302 107910 258959 64131561
Chromaturia 22.81 14.05 5 108207 22606 64367914
Autoimmune neutropenia 22.78 14.05 12 108200 406 64390114
Transdifferentiation of neoplasm 22.78 14.05 8 108204 96 64390424
Scedosporium infection 22.74 14.05 18 108194 1236 64389284
Folliculitis 22.71 14.05 11 108201 30066 64360454
Fanconi syndrome acquired 22.70 14.05 24 108188 2397 64388123
Pericarditis 22.68 14.05 44 108168 62472 64328048
Arterial thrombosis 22.62 14.05 24 108188 2406 64388114
Toxic neuropathy 22.62 14.05 15 108197 781 64389739
Cerebral venous thrombosis 22.53 14.05 24 108188 2417 64388103
Candida sepsis 22.53 14.05 23 108189 2205 64388315
Disseminated aspergillosis 22.47 14.05 14 108198 654 64389866
Skin toxicity 22.44 14.05 40 108172 6562 64383958
Blood pressure diastolic decreased 22.36 14.05 5 108207 22296 64368224
Pregnancy 22.33 14.05 4 108208 20861 64369659
Mucocutaneous ulceration 22.28 14.05 11 108201 324 64390196
Liver function test abnormal 22.26 14.05 41 108171 59360 64331160
Eczema 22.24 14.05 11 108201 29709 64360811
Dyskinesia 22.19 14.05 20 108192 39368 64351152
Acute monocytic leukaemia 22.12 14.05 12 108200 431 64390089
Mucosal infection 22.07 14.05 12 108200 433 64390087
Sinus polyp 21.80 14.05 12 108200 444 64390076
Iron deficiency anaemia 21.76 14.05 5 108207 21884 64368636
Dysstasia 21.73 14.05 6 108206 23209 64367311
Multiple sclerosis 21.70 14.05 3 108209 18938 64371582
Basal cell naevus syndrome 21.65 14.05 6 108206 30 64390490
Primitive neuroectodermal tumour 21.49 14.05 6 108206 31 64390489
Hypertensive hydrocephalus 21.48 14.05 5 108207 10 64390510
Gastroenteritis adenovirus 21.43 14.05 10 108202 259 64390261
Metastases to meninges 21.39 14.05 25 108187 2790 64387730
Cholelithiasis 21.29 14.05 27 108185 45479 64345041
Disorder of orbit 21.22 14.05 8 108204 119 64390401
Testicular malignant teratoma 21.16 14.05 5 108207 11 64390509
Right ventricular failure 21.15 14.05 5 108207 21466 64369054
Drug clearance decreased 21.14 14.05 24 108188 2595 64387925
Therapy interrupted 21.10 14.05 4 108208 20032 64370488
Epiphyses premature fusion 21.08 14.05 7 108205 70 64390450
Hot flush 21.05 14.05 28 108184 46207 64344313
Cerebellar tumour 20.99 14.05 7 108205 71 64390449
Administration related reaction 20.98 14.05 8 108204 123 64390397
Adenocarcinoma gastric 20.92 14.05 19 108193 1576 64388944
Cerebellar haemangioma 20.90 14.05 7 108205 72 64390448
Ileus 20.79 14.05 85 108127 22881 64367639
Pneumomediastinum 20.79 14.05 25 108187 2875 64387645
Bacterial tracheitis 20.74 14.05 6 108206 36 64390484
Guillain-Barre syndrome 20.69 14.05 42 108170 7593 64382927
Cardiac disorder 20.50 14.05 39 108173 55777 64334743
Terminal ileitis 20.49 14.05 13 108199 627 64389893
Autoimmune haemolytic anaemia 20.46 14.05 40 108172 7036 64383484
Pain in jaw 20.33 14.05 23 108189 40732 64349788
Haematopoietic stem cell mobilisation 20.27 14.05 9 108203 207 64390313
Basal ganglion degeneration 20.23 14.05 11 108201 397 64390123
Upper respiratory tract infection 20.22 14.05 59 108153 72726 64317794
Agitation 20.19 14.05 78 108134 88289 64302231
Small cell carcinoma 20.15 14.05 10 108202 298 64390222
Acute lymphocytic leukaemia refractory 20.13 14.05 8 108204 138 64390382
Sputum discoloured 20.06 14.05 3 108209 17853 64372667
Gait inability 19.97 14.05 25 108187 42343 64348177
Lymphoma transformation 19.92 14.05 9 108203 216 64390304
Skin laceration 19.90 14.05 8 108204 24409 64366111
Depressed level of consciousness 19.84 14.05 70 108142 81366 64309154
Product administered to patient of inappropriate age 19.82 14.05 31 108181 4570 64385950
Tumour necrosis 19.80 14.05 19 108193 1690 64388830
Premature ageing 19.78 14.05 7 108205 86 64390434
Respiratory syncytial virus infection 19.72 14.05 40 108172 7228 64383292
Peripheral sensorimotor neuropathy 19.71 14.05 23 108189 2562 64387958
Ocular vascular disorder 19.69 14.05 11 108201 419 64390101
Pneumocystis jirovecii infection 19.68 14.05 22 108190 2339 64388181
Central nervous system lymphoma 19.61 14.05 20 108192 1915 64388605
Drug clearance increased 19.51 14.05 9 108203 227 64390293
Full blood count abnormal 19.44 14.05 13 108199 29744 64360776
Retinopathy 19.36 14.05 26 108186 3339 64387181
Gallbladder empyema 19.35 14.05 7 108205 92 64390428
Hepatic failure 19.34 14.05 159 108053 55235 64335285
Visceral oedema 19.15 14.05 5 108207 19 64390501
Ascites 19.05 14.05 173 108039 61828 64328692
Epstein-Barr viraemia 18.99 14.05 19 108193 1778 64388742
Hiatus hernia 18.98 14.05 5 108207 19952 64370568
Enterobacter bacteraemia 18.93 14.05 12 108200 578 64389942
Radiation injury 18.87 14.05 13 108199 721 64389799
Platelet transfusion 18.87 14.05 19 108193 1792 64388728
Tooth disorder 18.82 14.05 7 108205 22395 64368125
Abdominal compartment syndrome 18.71 14.05 17 108195 1411 64389109
Clostridial infection 18.68 14.05 32 108180 5087 64385433
Withdrawal syndrome 18.66 14.05 8 108204 23484 64367036
Lacrimation increased 18.62 14.05 4 108208 18342 64372178
Blood urine present 18.61 14.05 4 108208 18336 64372184
Vulvovaginal inflammation 18.56 14.05 11 108201 469 64390051
Frequent bowel movements 18.56 14.05 4 108208 18301 64372219
Engraft failure 18.55 14.05 12 108200 599 64389921
Hepatic function abnormal 18.53 14.05 177 108035 64136 64326384
Acanthamoeba infection 18.44 14.05 11 108201 475 64390045
Peripheral artery thrombosis 18.43 14.05 24 108188 2991 64387529
Atypical teratoid/rhabdoid tumour of CNS 18.39 14.05 5 108207 23 64390497
Pneumonia cytomegaloviral 18.37 14.05 29 108183 4310 64386210
Inflammatory pseudotumour 18.34 14.05 6 108206 57 64390463
Mucosal toxicity 18.31 14.05 11 108201 481 64390039
Neuroendocrine tumour of the lung metastatic 18.27 14.05 7 108205 109 64390411
Inappropriate antidiuretic hormone secretion 18.24 14.05 80 108132 22209 64368311
Sleep apnoea syndrome 18.22 14.05 14 108198 29818 64360702
Ewing's sarcoma 18.21 14.05 5 108207 24 64390496
Flushing 18.19 14.05 207 108005 78441 64312079
Testicular germ cell cancer metastatic 18.16 14.05 6 108206 59 64390461
Cardiac arrest 18.13 14.05 168 108044 153896 64236624
Bone marrow infiltration 18.11 14.05 11 108201 491 64390029
Colitis ulcerative 18.04 14.05 8 108204 23020 64367500
Asthenia 17.98 14.05 564 107648 427480 63963040
Lethargy 17.95 14.05 62 108150 72532 64317988
Vulvovaginitis 17.92 14.05 9 108203 275 64390245
Neurological decompensation 17.89 14.05 29 108183 4407 64386113
Kidney infection 17.88 14.05 4 108208 17834 64372686
Heart rate irregular 17.87 14.05 12 108200 27401 64363119
Subdural haemorrhage 17.86 14.05 32 108180 5271 64385249
Adenomatous polyposis coli 17.82 14.05 8 108204 189 64390331
Glioblastoma multiforme 17.76 14.05 15 108197 1129 64389391
Serum ferritin increased 17.74 14.05 42 108170 8426 64382094
Blindness cortical 17.67 14.05 13 108199 800 64389720
Hemianopia 17.62 14.05 17 108195 1522 64388998
Stomatitis necrotising 17.56 14.05 8 108204 196 64390324
Hepatic infection fungal 17.56 14.05 8 108204 196 64390324
Neuroblastoma recurrent 17.55 14.05 6 108206 66 64390454
B precursor type acute leukaemia 17.49 14.05 9 108203 290 64390230
Skin discolouration 17.47 14.05 20 108192 35235 64355285
Hepatorenal failure 17.45 14.05 15 108197 1157 64389363
Pyomyositis 17.37 14.05 11 108201 529 64389991
Mood swings 17.34 14.05 4 108208 17464 64373056
Minimal residual disease 17.30 14.05 10 108202 407 64390113
Viral hepatitis carrier 17.28 14.05 5 108207 30 64390490
Fracture 17.27 14.05 5 108207 18750 64371770
Dry eye 17.24 14.05 14 108198 29005 64361515
Scrotal abscess 17.21 14.05 10 108202 411 64390109
Atypical haemolytic uraemic syndrome 17.19 14.05 12 108200 680 64389840
Procalcitonin decreased 17.19 14.05 4 108208 8 64390512
Primary mediastinal large B-cell lymphoma recurrent 17.16 14.05 6 108206 71 64390449
Human polyomavirus infection 17.15 14.05 14 108198 1005 64389515
Rhinorrhoea 17.10 14.05 48 108164 59921 64330599
Arteriosclerosis 17.09 14.05 3 108209 15874 64374646
Renal tubular dysfunction 17.07 14.05 12 108200 688 64389832
Transformation to acute myeloid leukaemia 17.01 14.05 13 108199 848 64389672
Splenic infarction 16.98 14.05 24 108188 3233 64387287
Blastic plasmacytoid dendritic cell neoplasia 16.79 14.05 6 108206 76 64390444
Pulmonary veno-occlusive disease 16.78 14.05 16 108196 1412 64389108
Retinal ischaemia 16.76 14.05 12 108200 708 64389812
Pneumonia respiratory syncytial viral 16.75 14.05 16 108196 1415 64389105
Clostridium test positive 16.73 14.05 27 108185 4088 64386432
Spindle cell sarcoma 16.67 14.05 8 108204 221 64390299
Aspiration bone marrow abnormal 16.67 14.05 7 108205 140 64390380
Follicular thyroid cancer 16.65 14.05 6 108206 78 64390442
Schistocytosis 16.62 14.05 5 108207 35 64390485
Extrapyramidal disorder 16.61 14.05 6 108206 19546 64370974
Pharyngeal oedema 16.57 14.05 3 108209 15528 64374992
Hypertensive crisis 16.56 14.05 5 108207 18243 64372277
Procedural pain 16.54 14.05 3 108209 15505 64375015
Medulloblastoma 16.51 14.05 6 108206 80 64390440
Ganglioneuroma 16.49 14.05 7 108205 144 64390376
Vitreous haemorrhage 16.48 14.05 23 108189 3062 64387458
Tissue infiltration 16.43 14.05 11 108201 582 64389938
Cerebral fungal infection 16.42 14.05 9 108203 330 64390190
Granulocyte count decreased 16.35 14.05 15 108197 1261 64389259
Intussusception 16.33 14.05 13 108199 900 64389620
Joint range of motion decreased 16.33 14.05 6 108206 19337 64371183
CNS ventriculitis 16.32 14.05 9 108203 334 64390186
Hydrocephalus 16.28 14.05 38 108174 7553 64382967
Hepatitis D 16.27 14.05 5 108207 38 64390482
Chronic myelomonocytic leukaemia 16.25 14.05 12 108200 743 64389777
Coronary artery thrombosis 16.25 14.05 22 108190 2847 64387673
Pneumocephalus 16.16 14.05 8 108204 237 64390283
Sneezing 16.16 14.05 3 108209 15248 64375272
Metastases to breast 16.16 14.05 8 108204 237 64390283
Growth hormone deficiency 16.13 14.05 9 108203 342 64390178
Meningitis tuberculous 16.09 14.05 14 108198 1097 64389423
Musculoskeletal disorder 16.08 14.05 5 108207 17901 64372619
Body temperature decreased 16.05 14.05 12 108200 25916 64364604
Renal infarct 16.01 14.05 20 108192 2391 64388129
Mucosal ulceration 15.98 14.05 17 108195 1710 64388810
Uterine enlargement 15.89 14.05 12 108200 769 64389751
Cold sweat 15.88 14.05 4 108208 16451 64374069
Tonsillar haemorrhage 15.86 14.05 8 108204 247 64390273
Neutropenic infection 15.85 14.05 18 108194 1947 64388573
Feeling hot 15.83 14.05 33 108179 45630 64344890
Retinal toxicity 15.81 14.05 15 108197 1315 64389205
Papilloedema 15.78 14.05 31 108181 5474 64385046
Dystonia 15.68 14.05 6 108206 18859 64371661
Mania 15.64 14.05 4 108208 16282 64374238
Musculoskeletal discomfort 15.63 14.05 4 108208 16273 64374247
Brain sarcoma 15.58 14.05 4 108208 14 64390506
Autologous bone marrow transplantation therapy 15.58 14.05 4 108208 14 64390506
Bone sarcoma 15.57 14.05 6 108206 95 64390425
Clostridium difficile infection 15.54 14.05 109 108103 36054 64354466
Peripheral T-cell lymphoma unspecified recurrent 15.43 14.05 5 108207 46 64390474
Appendicitis 15.41 14.05 54 108158 13515 64377005
Nightmare 15.37 14.05 8 108204 20985 64369535
Urinary bladder haematoma 15.36 14.05 4 108208 15 64390505
Colony stimulating factor therapy 15.35 14.05 10 108202 505 64390015
Restlessness 15.32 14.05 27 108185 39758 64350762
Angina pectoris 15.27 14.05 33 108179 45048 64345472
Platelet disorder 15.23 14.05 19 108193 2268 64388252
Anti-platelet antibody positive 15.18 14.05 8 108204 271 64390249
Subcutaneous emphysema 15.17 14.05 16 108196 1593 64388927
Noctiphobia 15.16 14.05 4 108208 16 64390504
Cerebral artery occlusion 15.16 14.05 16 108196 1595 64388925
Pneumonia adenoviral 15.12 14.05 7 108205 178 64390342
Central nervous system necrosis 15.04 14.05 8 108204 276 64390244
Psychomotor hyperactivity 14.98 14.05 3 108209 14448 64376072
Hepatomegaly 14.90 14.05 62 108150 16820 64373700
Fusobacterium infection 14.87 14.05 6 108206 108 64390412
Sarcoma 14.84 14.05 11 108201 685 64389835
Hypoglossal nerve paresis 14.82 14.05 6 108206 109 64390411
Idiopathic pneumonia syndrome 14.77 14.05 10 108202 539 64389981
Gastrointestinal disorder 14.77 14.05 89 108123 89620 64300900
Photosensitivity reaction 14.74 14.05 6 108206 18167 64372353
B-cell lymphoma refractory 14.72 14.05 6 108206 111 64390409
Bacillus bacteraemia 14.72 14.05 6 108206 111 64390409
Pulmonary fibrosis 14.61 14.05 93 108119 29785 64360735
VIth nerve paralysis 14.58 14.05 15 108197 1451 64389069
Hepatic lesion 14.56 14.05 31 108181 5793 64384727
Infected neoplasm 14.56 14.05 8 108204 295 64390225
Human chorionic gonadotropin increased 14.55 14.05 12 108200 874 64389646
Acute graft versus host disease in liver 14.55 14.05 16 108196 1671 64388849
Prescribed underdose 14.53 14.05 6 108206 18009 64372511
Myeloproliferative neoplasm 14.51 14.05 12 108200 877 64389643
Rectal haemorrhage 14.48 14.05 54 108158 61763 64328757
Testicular cancer metastatic 14.47 14.05 5 108207 57 64390463
Opportunistic infection 14.45 14.05 20 108192 2642 64387878
Thymus enlargement 14.43 14.05 6 108206 117 64390403
Listeria encephalitis 14.41 14.05 8 108204 301 64390219
Blast cell count increased 14.40 14.05 14 108198 1265 64389255
Spinal cord infarction 14.37 14.05 10 108202 564 64389956
Oesophageal fistula 14.36 14.05 8 108204 303 64390217
Hyperadrenocorticism 14.24 14.05 8 108204 308 64390212
Paraneoplastic syndrome 14.23 14.05 12 108200 901 64389619
Crying 14.20 14.05 8 108204 20082 64370438
Listeriosis 14.15 14.05 17 108195 1953 64388567
Hodgkin's disease recurrent 14.12 14.05 4 108208 22 64390498
Tooth hypoplasia 14.06 14.05 7 108205 210 64390310

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01CB01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Podophyllotoxin derivatives
FDA MoA N0000000176 Topoisomerase Inhibitors
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:59517 DNA synthesis inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D000972 Antineoplastic Agents, Phytogenic
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
FDA EPC N0000175609 Topoisomerase Inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Small cell carcinoma of lung indication 254632001 DOID:5409
Malignant tumor of testis indication 363449006 DOID:2998
Treatment prior to tumor-specific T-cell infusion therapy indication
Allogeneic bone marrow transplantation off-label use 58390007
Ewing's sarcoma off-label use 76909002 DOID:3369
Acute myeloid leukemia, disease off-label use 91861009
Kaposi's sarcoma off-label use 109385007
Diffuse non-Hodgkin's lymphoma, large cell off-label use 109969005
Multiple myeloma off-label use 109989006 DOID:9538
Hodgkin's disease off-label use 118599009
Burkitt's lymphoma off-label use 118617000
Non-small cell lung cancer off-label use 254637007 DOID:3908
Osteosarcoma of bone off-label use 307576001 DOID:3376
Malignant tumor of ovary off-label use 363443007 DOID:2394
Neuroblastoma off-label use 432328008 DOID:769
Ovarian Germ Cell Tumor Carcinoma off-label use
Neuroendocrine Prostate Carcinoma off-label use
Progressive Diffuse Large B-Cell Lymphoma off-label use
Testicular Germ Cell Tumor off-label use
Acute hemorrhage contraindication 8573003
Fibrosis of lung contraindication 51615001 DOID:3770
Metabolic acidosis contraindication 59455009
Acute infectious disease contraindication 63171007
Interstitial pneumonia contraindication 64667001
Leukopenia contraindication 84828003 DOID:615
Hypoalbuminemia contraindication 119247004
Impaired renal function disorder contraindication 197663003
Drug-induced hepatitis contraindication 235876009
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Breastfeeding (mother) contraindication 413712001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.96 acidic
pKa2 13.08 acidic
pKa3 13.86 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA topoisomerase 2-alpha Enzyme INHIBITOR IC50 7.30 IUPHAR CHEMBL
Canalicular multispecific organic anion transporter 1 Transporter Km 3.21 WOMBAT-PK
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor WOMBAT-PK
Multidrug resistance-associated protein 1 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 6 Transporter WOMBAT-PK
Canalicular multispecific organic anion transporter 2 Transporter WOMBAT-PK
DNA topoisomerase 2-beta Enzyme IC50 7.16 CHEMBL
Multidrug resistance protein 1 Transporter Ki 3.28 WOMBAT-PK
Arachidonate 15-lipoxygenase Enzyme IC50 5.50 DRUG MATRIX

External reference:

IDSource
4018141 VUID
N0000146478 NUI
D00125 KEGG_DRUG
4018141 VANDF
C0015133 UMLSCUI
CHEBI:4911 CHEBI
EVP PDB_CHEM_ID
CHEMBL44657 ChEMBL_ID
D005047 MESH_DESCRIPTOR_UI
DB00773 DRUGBANK_ID
6815 IUPHAR_LIGAND_ID
3835 INN_ID
6PLQ3CP4P3 UNII
36462 PUBCHEM_CID
220347 RXNORM
4209 MMSL
4709 MMSL
6665 MMSL
d00230 MMSL
002674 NDDF
387316009 SNOMEDCT_US
56928005 SNOMEDCT_US
CHEMBL1200645 ChEMBL_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9376 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9510 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9511 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0143-9512 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 0378-3266 CAPSULE 50 mg ORAL ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5653 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5656 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Toposar HUMAN PRESCRIPTION DRUG LABEL 1 0703-5657 INJECTION, SOLUTION, CONCENTRATE 20 mg INTRAVENOUS ANDA 24 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 16729-114 INJECTION 20 mg INTRAVENOUS ANDA 22 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 63323-104 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 14 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 63323-104 INJECTION, SOLUTION 20 mg INTRAVENOUS ANDA 14 sections
Etoposide HUMAN PRESCRIPTION DRUG LABEL 1 68001-265 INJECTION 20 mg INTRAVENOUS ANDA 22 sections