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etofylline clofibrate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| clofibrate derivatives, peroxisome proliferator activated receptor-alpha(PPAR-alpha) agonists | 1108 | 54504-70-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
whole issue; structure given in first source
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 80 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP3K21,MAP3K7,MAPK7,MARK4,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKDC,SIK2,SIK3,STK33,TEK,TTK | 32 | |||
| kinase-selectivity-class | AXL,GRK2,MAPK7,PRKDC | 4 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D001993 | Bronchodilator Agents |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018927 | Anti-Asthmatic Agents |
| MeSH PA | D019141 | Respiratory System Agents |
| MeSH PA | D000960 | Hypolipidemic Agents |
| MeSH PA | D000963 | Antimetabolites |
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D011838 | Radiation-Sensitizing Agents |
| MeSH PA | D020011 | Protective Agents |
| MeSH PA | D057847 | Lipid Regulating Agents |
| MeSH PA | D000924 | Anticholesteremic Agents |
| CHEBI has role | CHEBI:24527 | herbicide |
| CHEBI has role | CHEBI:35610 | antineoplastic agent |
| CHEBI has role | CHEBI:35679 | antilipemic drug |
| CHEBI has role | CHEBI:35821 | anticholesteremic drug |
| CHEBI has role | CHEBI:70782 | PPARα agonist |
| CHEBI has role | CHEBI:83399 | marine xenobiotic metabolite |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.29 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D06102 | KEGG_DRUG |
| C0059870 | UMLSCUI |
| CHEBI:135681 | CHEBI |
| CHEMBL1318939 | ChEMBL_ID |
| C028764 | MESH_SUPPLEMENTAL_RECORD_UI |
| 41109 | PUBCHEM_CID |
| 236713 | RXNORM |
| 005937 | NDDF |
| 006657 | NDDF |
| 712689006 | SNOMEDCT_US |
| C0009003 | UMLSCUI |
| C0059871 | UMLSCUI |
| 2797 | PUBCHEM_CID |
| 1892 | PUBCHEM_CID |
| 4271 | INN_ID |
| 2439 | INN_ID |
| 1667 | INN_ID |
| C008749 | MESH_SUPPLEMENTAL_RECORD_UI |
| D002995 | MESH_DESCRIPTOR_UI |
| 14UH1JQP6L | UNII |
| CHEBI:34648 | CHEBI |
| CHEBI:94764 | CHEBI |
Pharmaceutical products:
None