etofylline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
N-methylated xanthine derivatives 1107 519-37-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • aethophyllinum
  • ascorphylline
  • cordalin
  • dilaphyllin
  • etophyllin
  • etophylline
  • hydroxyethyltheophylline
  • oxphylline
  • oxyethophylline
  • oxyethyltheophylline
  • oxyphyllin
  • oxyphylline
  • oxytheonyl
  • etofylline
etophyllin appeared once in PubMed: Wien Med Wochenschr. 1986 May 15;136(9):213-8 as a combination drug with theophylline (spelt without e, theophllin)
  • Molecular weight: 224.22
  • Formula: C9H12N4O3
  • CLOGP: -0.87
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 78.67
  • ALOGS: -1.10
  • ROTB: 2

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 80 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.55 acidic
pKa2 1.64 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Adenosine receptor A2b GPCR Ki 4.76 CHEMBL

External reference:

IDSource
D07933 KEGG_DRUG
C0059871 UMLSCUI
CHEBI:94764 CHEBI
CHEMBL699 ChEMBL_ID
1892 PUBCHEM_CID
C008749 MESH_SUPPLEMENTAL_RECORD_UI
1667 INN_ID
L164909TBI UNII
24611 RXNORM
005937 NDDF
712689006 SNOMEDCT_US

Pharmaceutical products:

None