All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

ethoxzolamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	1089	452-35-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: ethoxzolamide ethoxyzolamide etoxzolamide ethamide	A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. Molecular weight: 258.31 Formula: C9H10N2O3S2 CLOGP: 2.05 LIPINSKI: 0 HAC: 5 HDO: 1 TPSA: 82.28 ALOGS: -2.57 ROTB: 3 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

None

ADMET properties:

Property	Value	Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)	55.30 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	65 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
S (Water solubility)	0.06 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Bocci G, Oprea TI, Benet LZ

Approvals:

Date	Agency	Company	Orphan
None	FDA	PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D002257	Carbonic Anhydrase Inhibitors
MeSH PA	D004232	Diuretics
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D045283	Natriuretic Agents
CHEBI has role	CHEBI:23018	EC 4.2.1.1 inhibitor
CHEBI has role	CHEBI:35498	diuretics
CHEBI has role	CHEBI:39456	antiglaucoma agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.04	acidic
pKa2	2.33	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	INHIBITOR	Ki	9.31		CHEMBL	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN	INHIBITOR	Kd	7.85		CHEMBL	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	INHIBITOR	Ki	7.03		CHEMBL	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN	INHIBITOR	Ki	7.47		CHEMBL	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN	INHIBITOR	Ki	7.66		CHEMBL	CHEMBL
Carbonic anhydrase 5A, mitochondrial	Enzyme	P35218	CAH5A_HUMAN	INHIBITOR	Ki	7.60		CHEMBL	CHEMBL
Carbonic anhydrase 5B, mitochondrial	Enzyme	Q9Y2D0	CAH5B_HUMAN	INHIBITOR	Ki	7.72		CHEMBL	CHEMBL
Carbonic anhydrase 7	Enzyme	P43166	CAH7_HUMAN	INHIBITOR	Kd	9.15		CHEMBL	CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN	INHIBITOR	Ki	5.30		CHEMBL	CHEMBL
Carbonic anhydrase 6	Enzyme	P23280	CAH6_HUMAN	INHIBITOR	Kd	7.48		CHEMBL	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN	INHIBITOR	Ki	8.60		CHEMBL	CHEMBL
Carbonic anhydrase 13	Enzyme	Q8N1Q1	CAH13_HUMAN	INHIBITOR	Kd	7.89		CHEMBL	CHEMBL
Carbonic anhydrase V	Enzyme	P35218 Q9Y2D0	CAH5A_HUMAN CAH5B_HUMAN	INHIBITOR	Ki	8.70		CHEMBL	CHEMBL
Carbonic anhydrase 4	Enzyme		CAH4_BOVIN		Ki	7.89		CHEMBL
Carbonic anhydrase	Enzyme		CAH_METTE		Ki	6.70		CHEMBL
Carbonic anhydrase	Enzyme		Q50565_METTH		Ki	5.27		CHEMBL
Carbonic anhydrase, alpha family	Unclassified		Q31FD6_HYDCU		Ki	8.39		CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE		Ki	7.24		CHEMBL
Carbonic anhydrase	Enzyme		CAN_YEAST		Ki	7.01		CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL		Ki	8.10		CHEMBL
Carbonic anhydrase	Enzyme		Q6FTL6_CANGA		Ki	5.51		CHEMBL
Alpha carbonic anhydrase	Enzyme		B5SU02_9CNID		Ki	7.40		CHEMBL
Carbonic anhydrase	Enzyme		C0IX24_9CNID		Ki	6.98		CHEMBL
Carbonic anhydrase 2	Enzyme		Q3I4V7_CRYNV		Ki	7.06		CHEMBL
Astrosclerin-3	Enzyme		A6YCJ1_9METZ		Ki	6.41		CHEMBL
Beta-carbonic anhydrase 1	Enzyme		MTCA1_MYCTU		Ki	5.99		CHEMBL
Delta carbonic anhydrase	Unclassified		Q5U9J1_THAWE		Ki	7.07		CHEMBL
Carbonic anhydrase 2	Enzyme		MTCA2_MYCTU		Ki	7.57		CHEMBL
Carbonic anhydrase	Enzyme		CYNT_HELPY		Ki	6.81		CHEMBL
Carbonate dehydratase	Enzyme		B2V8E3_SULSY		Ki	8.03		CHEMBL
Carbonic anhydrase 3	Enzyme		CAH3_BOVIN		Ki	5.02		CHEMBL
Carbonic anhydrase	Enzyme		Q5TU56_ANOGA		Ki	6.73		CHEMBL
Carbonic anhydrase 13	Enzyme		CAH13_MOUSE		Ki	7.30		CHEMBL

External reference:

ID	Source
C0015052	UMLSCUI
CHEBI:101096	CHEBI
EZL	PDB_CHEM_ID
CHEMBL18	ChEMBL_ID
DB00311	DRUGBANK_ID
D005016	MESH_DESCRIPTOR_UI
3295	PUBCHEM_CID
6814	IUPHAR_LIGAND_ID
Z52H4811WX	UNII
002290	NDDF
63203003	SNOMEDCT_US

Pharmaceutical products:

None