ethoxzolamide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1089 452-35-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ethoxzolamide
  • ethoxyzolamide
  • etoxzolamide
  • ethamide
A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.
  • Molecular weight: 258.31
  • Formula: C9H10N2O3S2
  • CLOGP: 2.05
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 82.28
  • ALOGS: -2.57
  • ROTB: 3

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 55.30 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 65 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
None FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002257 Carbonic Anhydrase Inhibitors
MeSH PA D004232 Diuretics
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D045283 Natriuretic Agents
CHEBI has role CHEBI:23018 carbonate dehydratase inhibitor
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:39456 antiglaucoma agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.04 acidic
pKa2 2.33 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 2 Enzyme INHIBITOR Ki 9.31 CHEMBL CHEMBL
Carbonic anhydrase 12 Enzyme INHIBITOR Ki 7.66 CHEMBL CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme INHIBITOR Ki 7.72 CHEMBL CHEMBL
Carbonic anhydrase 3 Enzyme INHIBITOR Ki 5.30 CHEMBL CHEMBL
Carbonic anhydrase 9 Enzyme INHIBITOR Ki 7.47 CHEMBL CHEMBL
Carbonic anhydrase 14 Enzyme INHIBITOR Ki 8.60 CHEMBL CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme INHIBITOR Ki 7.60 CHEMBL CHEMBL
Carbonic anhydrase 7 Enzyme INHIBITOR Kd 9.15 CHEMBL CHEMBL
Carbonic anhydrase 13 Enzyme INHIBITOR Kd 7.89 CHEMBL CHEMBL
Carbonic anhydrase 6 Enzyme INHIBITOR Kd 7.48 CHEMBL CHEMBL
Carbonic anhydrase V Enzyme INHIBITOR Ki 8.70 CHEMBL CHEMBL
Carbonic anhydrase 4 Enzyme INHIBITOR Ki 7.03 CHEMBL CHEMBL
Carbonic anhydrase 1 Enzyme INHIBITOR Kd 7.85 CHEMBL CHEMBL
Carbonic anhydrase 2 Enzyme Ki 7.57 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 7.89 CHEMBL
Carbonic anhydrase Unclassified Ki 6.73 CHEMBL
Carbonic anhydrase Unclassified Ki 6.98 CHEMBL
Carbonic anhydrase Enzyme Ki 5.51 CHEMBL
Delta carbonic anhydrase Unclassified Ki 7.07 CHEMBL
Carbonic anhydrase Enzyme Ki 7.01 CHEMBL
Carbonic anhydrase Enzyme Ki 5.27 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 7.30 CHEMBL
Carbonic anhydrase Enzyme Ki 6.81 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 7.24 CHEMBL
Alpha carbonic anhydrase Unclassified Ki 7.40 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.02 CHEMBL
Astrosclerin-3 Unclassified Ki 6.41 CHEMBL
Carbonic anhydrase Enzyme Ki 8.10 CHEMBL
Carbonic anhydrase Enzyme Ki 6.70 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 5.99 CHEMBL

External reference:

IDSource
C0877962 UMLSCUI
CHEBI:101096 CHEBI
EZL PDB_CHEM_ID
CHEMBL18 ChEMBL_ID
DB00311 DRUGBANK_ID
D005016 MESH_DESCRIPTOR_UI
3295 PUBCHEM_CID
6814 IUPHAR_LIGAND_ID
Z52H4811WX UNII
002290 NDDF
63203003 SNOMEDCT_US

Pharmaceutical products:

None