estriol succinate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
estrogens	1067	514-68-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

succinylestriol
estriol succinate sodium
estriol succinate disodium
estriol succinate disodium salt
estriol succinate
stiptanon

Molecular weight: 488.53
Formula: C26H32O9
CLOGP: 4.29
LIPINSKI: 0
HAC: 9
HDO: 3
TPSA: 147.43
ALOGS: -4.48
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	4.11	acidic
pKa2	4.71	acidic
pKa3	11.13	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Corticosteroid-binding globulin	Secreted	P08185	CBG_HUMAN		Ki	5		CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	5.26		CHEMBL
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		Ki	4.75		CHEMBL
Estrogen receptor	Nuclear hormone receptor	P03372	ESR1_HUMAN		Ki	9.32		CHEMBL
Estrogen receptor beta	Nuclear hormone receptor	Q92731	ESR2_HUMAN		EC50	9.90		CHEMBL
Sex hormone-binding globulin	Secreted	P04278	SHBG_HUMAN		Kd	6.63		CHEMBL
Alpha-synuclein	Transporter	P37840	SYUA_HUMAN		IC50	4.70		CHEMBL
Olfactory receptor 51E2	GPCR	Q9H255	O51E2_HUMAN		EC50	4.28		CHEMBL
Arachidonate 15-lipoxygenase	Enzyme		LOX15_RABIT		IC50	5.06		CHEMBL
Lanosterol 14-alpha demethylase	Enzyme		CP51_MYCTU		Kd	4		CHEMBL

External reference:

ID	Source
CHEBI:135790	CHEBI
CHEMBL193482	ChEMBL_ID
C009341	MESH_SUPPLEMENTAL_RECORD_UI
1558	INN_ID
AS13K2DY03	UNII
24416	RXNORM
005975	NDDF
C0059648	UMLSCUI
10577	PUBCHEM_CID

Pharmaceutical products:

None