estradiol benzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| estrogens | 1058 | 50-50-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 0.01 mg/mL | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Schizoaffective disorder | 139.35 | 61.62 | 24 | 462 | 3538 | 63484998 |
| Drug level increased | 95.01 | 61.62 | 24 | 462 | 22712 | 63465824 |
| Electrocardiogram QT prolonged | 72.17 | 61.62 | 24 | 462 | 59506 | 63429030 |
| Drug interaction | 63.64 | 61.62 | 32 | 454 | 229099 | 63259437 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA CS | M0447348 | Estradiol Congeners |
| FDA MoA | N0000000100 | Estrogen Receptor Agonists |
| MeSH PA | D004967 | Estrogens |
| MeSH PA | D006728 | Hormones |
| FDA EPC | N0000175825 | Estrogen |
| CHEBI has role | CHEBI:50114 | estrogens |
| CHEBI has role | CHEBI:62872 | quinoline oxidase inhibitors |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
| CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
| CHEBI has role | CHEBI:83056 | Daphnia magna metabolites |
| CHEBI has role | CHEBI:176497 | geroprotectors |
| CHEBI has role | CHEBI:63951 | estrogen receptor agonists |
| CHEBI has role | CHEBI:76988 | xenoestrogens |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | To increase rate of weight gain | Indication |
| Cattle | To improve feed efficiency | Indication |
| Cattle | Synchronization of estrus/ovulation | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Synovex C, Synovex S | Zoetis Inc. | 2 |
| Synovex H | Zoetis Inc. | 2 |
| Component E-C with Tylan, Component E-S with Tylan | Elanco US Inc. | 3 |
| SYNOVEX Choice, SYNOVEX PLUS | Zoetis Inc. | 2 |
| SYNOVEX ONE FEEDLOT, SYNOVEX ONE Grower | Zoetis Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent serotonin transporter | Transporter | Ki | 5.71 | DRUG MATRIX | |||||
| Sodium-dependent noradrenaline transporter | Transporter | Ki | 4.77 | DRUG MATRIX | |||||
| 5-hydroxytryptamine receptor 2B | GPCR | Ki | 5.13 | DRUG MATRIX | |||||
| Glucocorticoid receptor | Nuclear hormone receptor | Ki | 5.64 | DRUG MATRIX | |||||
| Alpha-2C adrenergic receptor | GPCR | Ki | 5.45 | DRUG MATRIX | |||||
| Adenosine receptor A3 | GPCR | Ki | 4.91 | DRUG MATRIX | |||||
| Estrogen receptor | Nuclear hormone receptor | Ki | 7.75 | DRUG MATRIX | |||||
| Sex hormone-binding globulin | Secreted | Kd | 5.94 | CHEMBL | |||||
| Tyrosine-protein kinase Fyn | Kinase | IC50 | 4.64 | DRUG MATRIX | |||||
| Androgen receptor | Transcription factor | Ki | 8.16 | DRUG MATRIX | |||||
| Progesterone receptor | Transcription factor | Ki | 5.90 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| D01953 | KEGG_DRUG |
| 4017609 | VANDF |
| 4021205 | VANDF |
| C0167626 | UMLSCUI |
| CHEBI:77006 | CHEBI |
| CHEBI:16469 | CHEBI |
| EST | PDB_CHEM_ID |
| CHEMBL282575 | ChEMBL_ID |
| DB13953 | DRUGBANK_ID |
| 222757 | PUBCHEM_CID |
| 405 | INN_ID |
| 1S4CJB5ZGN | UNII |
| DB00783 | DRUGBANK_ID |
| 4083 | RXNORM |
| 12022 | MMSL |
| 4684 | MMSL |
| 6157 | MMSL |
| 73109 | MMSL |
| 73244 | MMSL |
| 8602 | MMSL |
| NOCODE | MMSL |
| d00537 | MMSL |
| 001265 | NDDF |
| 003687 | NDDF |
| 126172005 | SNOMEDCT_US |
| 12839006 | SNOMEDCT_US |
| 96349008 | SNOMEDCT_US |
| C0014912 | UMLSCUI |
| 406 | INN_ID |
| 5757 | PUBCHEM_CID |
| D004958 | MESH_DESCRIPTOR_UI |
Pharmaceutical products:
None