estradiol benzoate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
estrogens 1058 50-50-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • estradiol benzoate
  • benzhormovarine
  • benzoestrofol
  • benzofoline
  • dimenformon benzoate
  • estradiol monobenzoate
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids
  • Molecular weight: 376.50
  • Formula: C25H28O3
  • CLOGP: 5.93
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -6.30
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0447348 Estradiol Congeners
FDA MoA N0000000100 Estrogen Receptor Agonists
MeSH PA D004967 Estrogens
MeSH PA D006728 Hormones
FDA EPC N0000175825 Estrogen
CHEBI has role CHEBI:50114 estrogens
CHEBI has role CHEBI:62872 quinoline oxidase inhibitors
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:83056 Daphnia magna metabolites
CHEBI has role CHEBI:176497 geroprotectors
CHEBI has role CHEBI:63951 estrogen receptor agonists
CHEBI has role CHEBI:76988 xenoestrogens

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Cattle To increase rate of weight gain Indication
Cattle To improve feed efficiency Indication
Cattle Synchronization of estrus/ovulation Indication

🐶 Veterinary products

ProductApplicantIngredients
Synovex C, Synovex S Zoetis Inc. 2
Synovex H Zoetis Inc. 2
Component E-C with Tylan, Component E-S with Tylan Elanco US Inc. 3
SYNOVEX Choice, SYNOVEX PLUS Zoetis Inc. 2
SYNOVEX ONE FEEDLOT, SYNOVEX ONE Grower Zoetis Inc. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium-dependent serotonin transporter Transporter Ki 5.71 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 4.77 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 5.13 DRUG MATRIX
Glucocorticoid receptor Nuclear hormone receptor Ki 5.64 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 5.45 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 4.91 DRUG MATRIX
Estrogen receptor Nuclear hormone receptor Ki 7.75 DRUG MATRIX
Sex hormone-binding globulin Secreted Kd 5.94 CHEMBL
Tyrosine-protein kinase Fyn Kinase IC50 4.64 DRUG MATRIX
Androgen receptor Transcription factor Ki 8.16 DRUG MATRIX
Progesterone receptor Transcription factor Ki 5.90 DRUG MATRIX

External reference:

IDSource
D01953 KEGG_DRUG
4017609 VANDF
4021205 VANDF
C0167626 UMLSCUI
CHEBI:77006 CHEBI
CHEBI:16469 CHEBI
EST PDB_CHEM_ID
CHEMBL282575 ChEMBL_ID
DB13953 DRUGBANK_ID
222757 PUBCHEM_CID
405 INN_ID
1S4CJB5ZGN UNII
5757 PUBCHEM_CID
DB00783 DRUGBANK_ID
4083 RXNORM
12022 MMSL
4684 MMSL
6157 MMSL
73109 MMSL
73244 MMSL
8602 MMSL
NOCODE MMSL
d00537 MMSL
001265 NDDF
003687 NDDF
126172005 SNOMEDCT_US
12839006 SNOMEDCT_US
96349008 SNOMEDCT_US
C0014912 UMLSCUI
406 INN_ID
D004958 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None