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erythromycin propionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 1052 | 134-36-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A macrolide antibiotic, produced by Streptomyces erythreus. It is the lauryl sulfate salt of the propionic ester of erythromycin. This erythromycin salt acts primarily as a bacteriostatic agent. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 35 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.499 | High | 0.87 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 27.040 | High | 0.87 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 4.656 | 10^-6 cm/s | High | 0.87 |
| dh-clint | Dog hepatocyte intrinsic clearance | 18.578 | uL/min/10^6 cells | High | 0.87 |
| dppb | Dog plasma protein binding (% unbound) | 22.070 | % | High | 0.87 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 29.040 | % | High | 0.87 |
| herg | hERG pIC50 | 4.394 | pIC50 | High | 0.87 |
| hh-clint | Human hepatocyte intrinsic clearance | 6.237 | uL/min/10^6 cells | High | 0.87 |
| hlm-clint | Human liver microsomal intrinsic clearance | 68.549 | uL/min/mg protein | High | 0.87 |
| hppb | Human plasma protein binding (% unbound) | 25.830 | % | High | 0.87 |
| kinase-safety-class | ACVR2B,AXL,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK1,PDK2,PRKDC,TEK | 17 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 4.102 | High | 0.84 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 11.169 | High | 0.87 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 16.218 | High | 0.87 | |
| mppb | Mouse plasma protein binding (% unbound) | 25.970 | High | 0.87 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 19.055 | High | 0.87 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | High | 0.84 | |
| pppb | Pig plasma protein binding (% unbound) | 30.630 | % | High | 0.87 |
| rat-kpuu-brain | Rat brain Kpuu | 0.014 | % | High | 0.84 |
| rh-clint | Rat hepatocyte intrinsic clearance | 15.136 | uL/min/10^6 cells | High | 0.87 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 67.070 | % | High | 0.87 |
| rppb | Rat plasma protein binding (% unbound) | 23.770 | % | High | 0.87 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 450.817 | uM | High | 0.87 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| International normalised ratio fluctuation | 317.51 | 77.58 | 50 | 917 | 3043 | 90624437 |
| Bloody discharge | 302.54 | 77.58 | 46 | 921 | 2217 | 90625263 |
| Lyme disease | 273.44 | 77.58 | 46 | 921 | 4216 | 90623264 |
| Iron deficiency | 152.41 | 77.58 | 32 | 935 | 9580 | 90617900 |
| Secretion discharge | 125.90 | 77.58 | 30 | 937 | 15866 | 90611614 |
| Platelet count increased | 122.75 | 77.58 | 31 | 936 | 20828 | 90606652 |
| Therapeutic product effect incomplete | 112.53 | 77.58 | 50 | 917 | 193846 | 90433634 |
| Staphylococcal infection | 96.92 | 77.58 | 31 | 936 | 48408 | 90579072 |
| Drug hypersensitivity | 93.75 | 77.58 | 59 | 908 | 463550 | 90163930 |
| Infection | 85.63 | 77.58 | 51 | 916 | 362043 | 90265437 |
| Drug intolerance | 85.52 | 77.58 | 55 | 912 | 447536 | 90179944 |
| Red blood cell sedimentation rate increased | 80.73 | 77.58 | 31 | 936 | 82564 | 90544916 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| International normalised ratio fluctuation | 322.24 | 124.88 | 51 | 892 | 4029 | 110584327 |
| Bloody discharge | 311.85 | 124.88 | 47 | 896 | 2686 | 110585670 |
| Lyme disease | 290.39 | 124.88 | 47 | 896 | 4269 | 110584087 |
| Iron deficiency | 144.11 | 124.88 | 33 | 910 | 18443 | 110569913 |
| Secretion discharge | 130.59 | 124.88 | 31 | 912 | 20213 | 110568143 |
| Platelet count increased | 127.47 | 124.88 | 32 | 911 | 26302 | 110562054 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA CS | M0028311 | Macrolides |
| FDA PE | N0000009982 | Decreased Sebaceous Gland Activity |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D005765 | Gastrointestinal Agents |
| MeSH PA | D011500 | Protein Synthesis Inhibitors |
| CHEBI has role | CHEBI:23924 | enzyme inhibitor |
| FDA EPC | N0000175877 | Macrolide |
| FDA EPC | N0000175935 | Macrolide Antimicrobial |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:76969 | bacterial metabolite |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.61 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bile salt export pump | Transporter | IC50 | 5.39 | CHEMBL | |||||
| Bile salt export pump | Transporter | IC50 | 4.94 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02525 | KEGG_DRUG |
| 3521-62-8 | SECONDARY_CAS_RN |
| 4017593 | VANDF |
| 4017594 | VANDF |
| C0059564 | UMLSCUI |
| CHEBI:48913 | CHEBI |
| CHEMBL2220427 | ChEMBL_ID |
| CHEMBL2218877 | ChEMBL_ID |
| C011807 | MESH_SUPPLEMENTAL_RECORD_UI |
| HB75CIT999 | UNII |
| 71277 | PUBCHEM_CID |
| 4053 | RXNORM |
| 3636 | MMSL |
| 4675 | MMSL |
| 4676 | MMSL |
| 4799 | MMSL |
| 72164 | MMSL |
| d00046 | MMSL |
| 002755 | NDDF |
| 002756 | NDDF |
| 005412 | NDDF |
| 10270000 | SNOMEDCT_US |
| 30427009 | SNOMEDCT_US |
| 372694001 | SNOMEDCT_US |
| 734518007 | SNOMEDCT_US |
| D004918 | MESH_DESCRIPTOR_UI |
| C0014806 | UMLSCUI |
| DB00199 | DRUGBANK_ID |
| 12560 | PUBCHEM_CID |
| 39 | INN_ID |
| D004917 | MESH_DESCRIPTOR_UI |
| CHEBI:42355 | CHEBI |
Pharmaceutical products:
None