alatrofloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 102 | 146961-76-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
prodrug of trovafloxacin
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 22 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 18, 1997 | FDA | PFIZER |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000970 | Antineoplastic Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D059005 | Topoisomerase II Inhibitors |
| MeSH PA | D059003 | Topoisomerase Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
| Acute gonococcal cervicitis | indication | 20943002 | DOID:10615 |
| Staphylococcal pneumonia | indication | 22754005 | |
| Acute gonococcal urethritis | indication | 29864006 | |
| Postoperative infection | indication | 33910007 | |
| Pneumonia due to Streptococcus | indication | 34020007 | |
| Pneumonia due to Pseudomonas | indication | 41381004 | |
| Gonorrhea of rectum | indication | 42746002 | |
| Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
| Pneumonia due to Escherichia coli | indication | 51530003 | |
| Acute gonococcal endometritis | indication | 65295003 | DOID:7527 |
| Urinary tract infectious disease | indication | 68566005 | |
| Haemophilus influenzae pneumonia | indication | 70036007 | |
| Acute bacterial sinusitis | indication | 75498004 | |
| Female genital tract infection | indication | 125585007 | |
| Infectious disease of abdomen | indication | 128070006 | |
| Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
| Chlamydial pelvic inflammatory disease | indication | 188463006 | |
| Acute Moraxella catarrhalis bronchitis | indication | 195722003 | |
| Acute bacterial bronchitis | indication | 233598009 | |
| Chlamydial pneumonia | indication | 233609002 | |
| Staphylococcus Aureus Bronchitis | indication | ||
| Colorectal Surgery Infection Prevention | indication | ||
| Pelvic Inflammatory Disease with Neisseria Gonorrhea | indication | ||
| Streptococcus Pneumoniae Bronchitis | indication | ||
| Chronic Bacterial Prostatitis | indication | ||
| Legionella Pneumophila Pneumonia | indication | ||
| Haemophilus Influenzae Bronchitis | indication | ||
| Vaginal Hysterectomy Infection Prevention | indication | ||
| Moraxella Catarrhalis Pneumonia | indication | ||
| Chlamydia Cervicitis | indication | ||
| Haemophilus Parainfluenzae Bronchitis | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.92 | acidic |
| pKa2 | 12.1 | acidic |
| pKa3 | 13.23 | acidic |
| pKa4 | 8.47 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Topoisomerase IV | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
| DNA gyrase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021092 | VUID |
| N0000148548 | NUI |
| D02470 | KEGG_DRUG |
| 146961-77-5 | SECONDARY_CAS_RN |
| 141440 | RXNORM |
| CHEBI:135829 | CHEBI |
| CHEMBL1201197 | ChEMBL_ID |
| CHEMBL1200498 | ChEMBL_ID |
| C106856 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7495 | INN_ID |
| DB09335 | DRUGBANK_ID |
| 7QVV6I50DT | UNII |
| 116543002 | SNOMEDCT_US |
| 782143009 | SNOMEDCT_US |
| C0540776 | UMLSCUI |
| 4021092 | VANDF |
| 4024109 | VANDF |
| 5282517 | PUBCHEM_CID |
| 4140 | MMSL |
| 007322 | NDDF |
| 007323 | NDDF |
Pharmaceutical products:
None