alacepril 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| angiotensin-converting enzyme inhibitors | 101 | 74258-86-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
It is an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. It used for the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics).
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| April 6, 1981 | FDA | PAR PHARM |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| FDA MoA | N0000000181 | Angiotensin-converting Enzyme Inhibitors |
| FDA EPC | N0000175562 | Angiotensin Converting Enzyme Inhibitor |
| CHEBI has role | CHEBI:35457 | ACE inhibitor |
| CHEBI has role | CHEBI:35674 | antihypertensive drugs |
| MeSH PA | D000806 | Angiotensin-Converting Enzyme Inhibitors |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D011480 | Protease Inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Essential hypertension | indication | 59621000 | DOID:10825 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.61 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme | Enzyme | INHIBITOR | DRUG LABEL | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D01900 | KEGG_DRUG |
| 1998 | RXNORM |
| C0051050 | UMLSCUI |
| CHEBI:31182 | CHEBI |
| CHEBI:3380 | CHEBI |
| CHEMBL2103775 | ChEMBL_ID |
| C046835 | MESH_SUPPLEMENTAL_RECORD_UI |
| 71992 | PUBCHEM_CID |
| 5458 | INN_ID |
| X39TL7JDPF | UNII |
| 29439004 | SNOMEDCT_US |
| 387160004 | SNOMEDCT_US |
| C0006938 | UMLSCUI |
| DB01197 | DRUGBANK_ID |
| 4017614 | VANDF |
| 4373 | INN_ID |
| 4347 | MMSL |
| 455 | MMSL |
| d00006 | MMSL |
| D002216 | MESH_DESCRIPTOR_UI |
| 44093 | PUBCHEM_CID |
| 000656 | NDDF |
| 008152 | NDDF |
Pharmaceutical products:
None