dimemorfan 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 900 | 36309-01-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Interstitial lung disease | 63.52 | 37.25 | 27 | 680 | 112573 | 79631108 |
| Hepatic function abnormal | 42.70 | 37.25 | 18 | 689 | 73089 | 79670592 |
| Malignant neoplasm progression | 40.49 | 37.25 | 21 | 686 | 135969 | 79607712 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R05DA11 | RESPIRATORY SYSTEM COUGH AND COLD PREPARATIONS COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS Opium alkaloids and derivatives |
| MeSH PA | D000996 | Antitussive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D019141 | Respiratory System Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.55 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | INHIBITOR | Ki | 6.82 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| D07848 | KEGG_DRUG |
| C0058193 | UMLSCUI |
| CHEBI:135048 | CHEBI |
| CHEMBL2106325 | ChEMBL_ID |
| DB13810 | DRUGBANK_ID |
| C012621 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3037918 | PUBCHEM_CID |
| 3497 | INN_ID |
| 36304-84-4 | SECONDARY_CAS_RN |
| 623OAC38YU | UNII |
| 704651005 | SNOMEDCT_US |
| 704652003 | SNOMEDCT_US |
Pharmaceutical products:
None