noscapine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 1973 128-62-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • noscapine
  • methoxyhydrastine
  • narcompren
  • narcosine
  • noscapalin
  • noscapin
  • terbenol
  • vadebex
  • noscapine hydrochloride
  • noscapine HCl
A naturally occurring opium alkaloid that is a centrally acting antitussive agent.
  • Molecular weight: 413.43
  • Formula: C22H23NO7
  • CLOGP: 2.27
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 0
  • TPSA: 75.69
  • ALOGS: -3.36
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.13 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 30 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 16.88 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.13 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 422.98 225.19 133 295 200229 34756274

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 375.92 163.37 123 349 421417 79322499
Drug abuse 205.64 163.37 63 409 162628 79581288

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R05DA07 RESPIRATORY SYSTEM
COUGH AND COLD PREPARATIONS
COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
Opium alkaloids and derivatives
MeSH PA D000996 Antitussive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:51177 anti-tussive
CHEBI has role CHEBI:68495 Type I cell-death inducers
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tachyarrhythmia contraindication 6285003
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Pulmonary edema contraindication 19242006 DOID:11396
Myocardial infarction contraindication 22298006 DOID:5844
Shock contraindication 27942005
Hyperthyroidism contraindication 34486009 DOID:7998
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Hypothyroidism contraindication 40930008 DOID:1459
Third trimester pregnancy contraindication 41587001
Chronic heart failure contraindication 48447003
Multiple organ failure contraindication 57653000
Diabetes mellitus contraindication 73211009 DOID:9351
Cor pulmonale contraindication 83291003 DOID:8515
Seizure disorder contraindication 128613002
Cystic fibrosis contraindication 190905008 DOID:1485
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Sepsis syndrome contraindication 238150007
Continuous fever contraindication 271751000
Smoking cessation assistance contraindication 384742004
Smokes tobacco daily contraindication 449868002
Theophylline Toxicity contraindication
Severe Hypoxemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.51 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2C9 Enzyme IC50 5.09 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 6.40 DRUG MATRIX
Solute carrier family 22 member 2 Transporter IC50 5.59 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.46 CHEMBL

External reference:

IDSource
N0000166975 NUI
D01036 KEGG_DRUG
C0028426 UMLSCUI
CHEBI:73237 CHEBI
08N PDB_CHEM_ID
CHEMBL364713 ChEMBL_ID
D009665 MESH_DESCRIPTOR_UI
DB06174 DRUGBANK_ID
275196 PUBCHEM_CID
10212 IUPHAR_LIGAND_ID
632 INN_ID
912-60-7 SECONDARY_CAS_RN
8V32U4AOQU UNII
7533 RXNORM
001654 NDDF
006427 NDDF
387437002 SNOMEDCT_US
76696004 SNOMEDCT_US
CHEMBL2106732 ChEMBL_ID

Pharmaceutical products:

None