acepromazine indications/contra

Stem definitionDrug idCAS RN
73 61-00-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • acetylpromazine
  • acepromazin
  • acepromazine
  • acetacin
  • acetazin
  • acetazine
  • acetopromazine
  • azepromazine
  • acetopromazine maleate
  • acetopromazine maleate salt
A phenothiazine that is used in the treatment of PSYCHOSES.
  • Molecular weight: 326.46
  • Formula: C19H22N2OS
  • CLOGP: 4.38
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 23.55
  • ALOGS: -4.52
  • ROTB: 5

Drug dosage:

DoseUnitRoute
0.10 g O
50 mg P

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypothermia 108.69 93.63 14 9 3201 3382635

Pharmacologic Action:

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SourceCodeDescription
ATC N05AA04 NERVOUS SYSTEM
PSYCHOLEPTICS
ANTIPSYCHOTICS
Phenothiazines with aliphatic side-chain
CHEBI has role CHEBI:37930 phenothiazine antipsychotic drug
MeSH PA D014150 Antipsychotic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D015259 Dopamine Agents
MeSH PA D018492 Dopamine Antagonists
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.04 Basic
pKa2 1.82 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Major prion protein Surface antigen EC50 5.30 CHEMBL

External reference:

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IDSource
N0000167279 NUI
C0000959 UMLSCUI
D07065 KEGG_DRUG
54EJ303F0R UNII
667 INN_ID
CHEMBL39560 ChEMBL_ID
N0000167279 NDFRT
005220 NDDF
96218000 SNOMEDCT_US
155 RXNORM
6077 PUBCHEM_CID
DB01614 DRUGBANK_ID
D000075 MESH_DESCRIPTOR_UI
CHEBI:44932 CHEBI

Pharmaceutical products:

None