chlorproethazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	619	84-01-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

chlorproethazine
RP 4909
2-Chloro-10-(3-diethylaminopropyl)phenothiazine

Molecular weight: 346.92
Formula: C19H23ClN2S
CLOGP: 6.56
LIPINSKI: 1
HAC: 2
HDO: 0
TPSA: 6.48
ALOGS: -5.51
ROTB: 6

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	N05AA07	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Phenothiazines with aliphatic side-chain
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D009125	Muscle Relaxants, Central
MeSH PA	D009465	Neuromuscular Agents
MeSH PA	D018373	Peripheral Nervous System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.33	Basic
pKa2	2.21	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN		Ki	7.98		PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	7.99		PDSP
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	7.64		PDSP

External reference:

ID	Source
D07308	KEGG_DRUG
59860	RXNORM
C0164858	UMLSCUI
CHEBI:135464	CHEBI
CHEMBL52125	ChEMBL_ID
DB13382	DRUGBANK_ID
C054028	MESH_SUPPLEMENTAL_RECORD_UI
65750	PUBCHEM_CID
1147	INN_ID
960NX27Z07	UNII
005317	NDDF

Pharmaceutical products:

None