carvedilol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 522 72956-09-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carvedilol
  • carvedilol phosphate
  • carvediol
  • carvedilol hydrochloride
  • carvedilol HCl
  • BM 14,190
A carbazole and propanol derivative that acts as a non-cardioselective beta blocker and vasodilator. It has blocking activity for ALPHA 1 ADRENERGIC RECEPTORS and, at higher doses, may function as a blocker of CALCIUM CHANNELS; it also has antioxidant properties. Carvedilol is used in the treatment of HYPERTENSION; ANGINA PECTORIS; and HEART FAILURE. It can also reduce the risk of death following MYOCARDIAL INFARCTION.
  • Molecular weight: 406.48
  • Formula: C24H26N2O4
  • CLOGP: 4.04
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 75.74
  • ALOGS: -4.96
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
37.50 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.03 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.03 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.40 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 25 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2 61
kinase-selectivity-class AXL,BRAF,CDK9,DYRK1B,ERBB2,GRK2,MAPK7,PDK4,PIK3CD,SIK2,STK33,TTK 12
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1

Approvals:

DateAgencyCompanyOrphan
Sept. 14, 1995 FDA SMITHKLINE BEECHAM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1462.06 10.27 1104 110024 97590 90419729
Myocardial infarction 522.75 10.27 647 110481 105325 90411994
Hypotension 502.34 10.27 1181 109947 324216 90193103
Cardiac failure 448.62 10.27 610 110518 108886 90408433
BRASH syndrome 408.79 10.27 133 110995 1746 90515573
Bradycardia 402.33 10.27 505 110623 83342 90433977
Synovitis 337.35 10.27 16 111112 329736 90187583
Acute kidney injury 331.66 10.27 1003 110125 319384 90197935
Hand deformity 314.48 10.27 11 111117 296351 90220968
Glossodynia 312.59 10.27 21 111107 321758 90195561
Systemic lupus erythematosus 296.48 10.27 45 111083 361851 90155468
Infusion related reaction 292.99 10.27 75 111053 416705 90100614
Hyperkalaemia 270.61 10.27 365 110763 64599 90452720
Death 270.51 10.27 1192 109936 455359 90061960
Pericarditis 261.27 10.27 18 111110 270133 90247186
Duodenal ulcer perforation 255.15 10.27 3 111125 221285 90296034
Joint swelling 253.14 10.27 152 110976 503148 90014171
Helicobacter infection 242.10 10.27 8 111120 226842 90290477
Treatment failure 239.48 10.27 42 111086 303886 90213433
Wound 236.27 10.27 43 111085 302937 90214382
Acute myocardial infarction 234.31 10.27 250 110878 34640 90482679
Lower respiratory tract infection 233.08 10.27 20 111108 250639 90266680
Arthropathy 224.87 10.27 84 111044 366158 90151161
Hepatic enzyme increased 219.37 10.27 84 111044 360652 90156667
Folliculitis 218.80 10.27 7 111121 204346 90312973
Maternal exposure during pregnancy 218.70 10.27 84 111044 359979 90157340
Renal failure 206.52 10.27 480 110648 130527 90386792
Gastrointestinal haemorrhage 199.79 10.27 380 110748 89868 90427451
Atrial fibrillation 197.03 10.27 477 110651 133134 90384185
Cardiomyopathy 195.91 10.27 177 110951 20029 90497290
Drug intolerance 193.54 10.27 159 110969 447432 90069887
Completed suicide 193.05 10.27 498 110630 144560 90372759
Impaired healing 191.98 10.27 29 111099 234170 90283149
Rheumatoid arthritis 190.06 10.27 104 111024 362510 90154809
Drug ineffective 189.89 10.27 965 110163 1383333 89133986
Contraindicated product administered 187.34 10.27 79 111049 320060 90197259
Syncope 175.03 10.27 454 110674 132209 90385110
Ejection fraction decreased 174.31 10.27 187 110941 26066 90491253
Hypersensitivity 173.54 10.27 181 110947 454496 90062823
Coronary artery disease 173.23 10.27 210 110918 33413 90483906
Therapeutic product effect decreased 173.13 10.27 62 111066 277509 90239810
Chronic kidney disease 172.05 10.27 257 110871 49934 90467385
Dehydration 169.23 10.27 574 110554 193873 90323446
Dyspnoea 168.33 10.27 1733 109395 879222 89638097
Renal impairment 165.83 10.27 386 110742 105035 90412284
Alopecia 165.45 10.27 219 110909 494852 90022467
Irritable bowel syndrome 164.82 10.27 28 111100 207420 90309899
Musculoskeletal stiffness 161.34 10.27 81 111047 296451 90220868
Anaemia 155.46 10.27 847 110281 351955 90165364
Discomfort 146.16 10.27 77 111051 274258 90243061
Blood creatinine increased 144.16 10.27 357 110771 101029 90416290
C-reactive protein abnormal 141.50 10.27 3 111125 127426 90389893
Cerebrovascular accident 138.23 10.27 398 110730 123135 90394184
Psoriatic arthropathy 137.34 10.27 54 111074 228281 90289038
International normalised ratio increased 132.70 10.27 221 110907 47095 90470224
Fibromyalgia 132.17 10.27 44 111084 206225 90311094
Pulmonary oedema 131.97 10.27 257 110871 61823 90455496
Sleep disorder due to general medical condition, insomnia type 129.10 10.27 7 111121 128687 90388632
Liver injury 129.09 10.27 26 111102 170541 90346778
Hypoglycaemia 128.12 10.27 272 110856 69576 90447743
Drug interaction 128.03 10.27 673 110455 275780 90241539
Cardiac failure chronic 127.64 10.27 82 111046 5564 90511755
Haemoglobin decreased 120.28 10.27 454 110674 161502 90355817
Blister 119.83 10.27 83 111045 254915 90262404
Abdominal discomfort 119.76 10.27 254 110874 477074 90040245
Ill-defined disorder 117.48 10.27 40 111088 184851 90332468
Mental status changes 116.46 10.27 202 110926 44477 90472842
Off label use 116.14 10.27 834 110294 1101418 89415901
Blood glucose increased 114.51 10.27 315 110813 94931 90422388
Bursitis 113.30 10.27 14 111114 131640 90385679
Pain 113.28 10.27 737 110391 995604 89521715
Cardiac disorder 113.13 10.27 229 110899 56643 90460676
Cardiac arrest 111.55 10.27 332 110796 104603 90412716
Type 2 diabetes mellitus 111.28 10.27 55 111073 203189 90314130
Mobility decreased 110.84 10.27 87 111041 250647 90266672
Swelling 109.32 10.27 218 110910 418840 90098479
Joint range of motion decreased 108.40 10.27 18 111110 135625 90381694
Stomatitis 107.37 10.27 107 111021 274591 90242728
Gastrointestinal disorder 104.97 10.27 96 111032 256591 90260728
Lip dry 102.81 10.27 5 111123 100950 90416369
Blood pressure decreased 102.54 10.27 260 110868 74635 90442684
Fall 101.90 10.27 969 110159 480841 90036478
Oedema peripheral 100.21 10.27 599 110529 257316 90260003
Arthralgia 98.25 10.27 557 110571 777965 89739354
Shock 95.26 10.27 145 110983 28633 90488686
Cardiogenic shock 95.10 10.27 133 110995 24335 90492984
Urinary tract infection 95 10.27 671 110457 304961 90212358
Product use issue 93.64 10.27 163 110965 329756 90187563
Hypertensive crisis 93.11 10.27 112 111016 17672 90499647
Exposure during pregnancy 90.73 10.27 95 111033 238315 90279004
Hypervolaemia 87.86 10.27 150 110978 32607 90484712
Blood cholesterol increased 85.98 10.27 77 111051 207935 90309384
Glomerular filtration rate decreased 84.37 10.27 104 111024 16828 90500491
Wheezing 83.90 10.27 101 111027 237979 90279340
Congestive cardiomyopathy 82.49 10.27 70 111058 7284 90510035
Cardiomegaly 81.31 10.27 108 111020 18817 90498502
Full blood count decreased 81.02 10.27 137 110991 29552 90487767
Infection 80.06 10.27 206 110922 361888 90155431
Grip strength decreased 79.27 10.27 10 111118 92566 90424753
Anti-neutrophil cytoplasmic antibody positive vasculitis 78.14 10.27 53 111075 3940 90513379
Atrioventricular block 75.36 10.27 72 111056 8743 90508576
Sleep disorder 75.24 10.27 79 111049 197951 90319368
Inflammation 75.14 10.27 65 111063 178527 90338792
Pulmonary fibrosis 74.16 10.27 20 111108 107483 90409836
Sinusitis 73.70 10.27 198 110930 342890 90174429
Nasopharyngitis 73.17 10.27 255 110873 406849 90110470
Rash 72.60 10.27 626 110502 795474 89721845
Arrhythmia 70.95 10.27 159 110969 42173 90475146
Orthopnoea 70.47 10.27 62 111066 6773 90510546
Sinus bradycardia 70.17 10.27 95 111033 16857 90500462
Subdural haematoma 70.00 10.27 94 111034 16551 90500768
Urticaria 69.82 10.27 177 110951 312557 90204762
Drug hypersensitivity 69.59 10.27 312 110816 463297 90054022
Prescribed overdose 69.57 10.27 17 111111 97608 90419711
Plasma cell myeloma 69.16 10.27 154 110974 40674 90476645
Renal disorder 68.91 10.27 147 110981 37712 90479607
Blood urea increased 68.42 10.27 129 110999 30284 90487035
Unresponsive to stimuli 68.22 10.27 147 110981 37974 90479345
Migraine 67.89 10.27 80 111048 190312 90327007
Chest pain 66.04 10.27 640 110488 319005 90198314
Dizziness 65.10 10.27 1049 110079 588235 89929084
Intentional product use issue 64.42 10.27 104 111024 216788 90300531
Therapeutic product effect incomplete 64.41 10.27 86 111042 193810 90323509
Red blood cell sedimentation rate increased 63.72 10.27 12 111116 82583 90434736
Blood potassium increased 63.72 10.27 101 111027 20648 90496671
Asthenia 63.44 10.27 962 110166 532789 89984530
Blood loss anaemia 63.42 10.27 70 111058 10070 90507249
Mitral valve incompetence 62.87 10.27 105 111023 22419 90494900
Cardioactive drug level increased 62.40 10.27 38 111090 2346 90514973
Injury 62.09 10.27 91 111037 197258 90320061
Loss of consciousness 61.83 10.27 337 110791 139901 90377418
Toxicity to various agents 61.77 10.27 581 110547 287265 90230054
Diarrhoea 61.33 10.27 1545 109583 937645 89579674
Wound infection 60.98 10.27 27 111101 106375 90410944
Night sweats 60.33 10.27 42 111086 128724 90388595
Gastrointestinal tract mucosal pigmentation 59.84 10.27 25 111103 684 90516635
Peritonitis bacterial 59.60 10.27 50 111078 5121 90512198
Ischaemic cardiomyopathy 59.19 10.27 38 111090 2575 90514744
Ventricular hypokinesia 58.19 10.27 50 111078 5291 90512028
Live birth 57.91 10.27 13 111115 79094 90438225
Pregnancy 57.49 10.27 5 111123 62042 90455277
Hypercholesterolaemia 57.20 10.27 26 111102 100866 90416453
Osteoarthritis 57.05 10.27 95 111033 195635 90321684
Autoimmune disorder 55.40 10.27 13 111115 76731 90440588
Peripheral venous disease 55.33 10.27 17 111111 83904 90433415
Blood pressure increased 54.94 10.27 422 110706 196795 90320524
Cardio-respiratory arrest 54.50 10.27 186 110942 62954 90454365
Blepharospasm 52.67 10.27 4 111124 55441 90461878
Ischaemic stroke 52.34 10.27 96 111032 22070 90495249
Ventricular arrhythmia 52.34 10.27 43 111085 4278 90513041
Glycosylated haemoglobin increased 52.33 10.27 79 111049 15483 90501836
Pericardial effusion 51.58 10.27 129 110999 36704 90480615
Coronary arterial stent insertion 51.58 10.27 36 111092 2804 90514515
Cardiac failure acute 51.13 10.27 68 111060 11861 90505458
Respiratory failure 50.47 10.27 282 110846 118136 90399183
End stage renal disease 49.89 10.27 57 111071 8514 90508805
Fluid retention 49.67 10.27 227 110901 87864 90429455
Angina unstable 49.39 10.27 52 111076 7091 90510228
Lethargy 49.34 10.27 180 110948 62959 90454360
Dialysis 49.21 10.27 65 111063 11264 90506055
C-reactive protein increased 48.40 10.27 93 111035 181296 90336023
Suspected suicide 48.04 10.27 59 111069 9509 90507810
Distributive shock 47.72 10.27 37 111091 3387 90513932
Myocardial ischaemia 47.70 10.27 71 111057 13743 90503576
Hip arthroplasty 47.50 10.27 17 111111 76191 90441128
Bone erosion 47.20 10.27 5 111123 53016 90464303
Extradural haematoma 46.66 10.27 30 111098 2038 90515281
Condition aggravated 46.63 10.27 486 110642 595059 89922260
Cerebral infarction 45.81 10.27 101 111027 26495 90490824
Epilepsy 45.34 10.27 22 111106 82184 90435135
Blood pressure abnormal 45.03 10.27 84 111044 19561 90497758
Product dose omission issue 44.94 10.27 551 110577 291136 90226183
Acute respiratory failure 44.84 10.27 135 110993 42783 90474536
Hypovolaemia 44.52 10.27 65 111063 12366 90504953
Isosthenuria 44.48 10.27 13 111115 116 90517203
X-ray abnormal 43.95 10.27 3 111125 45421 90471898
Angina pectoris 43.60 10.27 126 111002 39034 90478285
Pulse absent 43.52 10.27 45 111083 6010 90511309
Foot deformity 43.26 10.27 10 111118 59641 90457678
Pyrexia 42.45 10.27 563 110565 659922 89857397
Road traffic accident 41.92 10.27 42 111086 107584 90409735
Lung disorder 41.62 10.27 75 111053 149808 90367511
Blood glucose decreased 41.52 10.27 90 111038 23339 90493980
Chronic obstructive pulmonary disease 41.43 10.27 190 110938 73639 90443680
Sciatica 41.31 10.27 38 111090 101344 90415975
Tricuspid valve incompetence 40.19 10.27 73 111055 16658 90500661
Coronary artery occlusion 40.15 10.27 51 111077 8503 90508816
Drug abuse 39.72 10.27 26 111102 82321 90434998
Calcium deficiency 39.45 10.27 23 111105 1310 90516009
Pyelitis 39.11 10.27 14 111114 249 90517070
Left ventricular dysfunction 39.11 10.27 67 111061 14602 90502717
Haemorrhage intracranial 38.79 10.27 68 111060 15094 90502225
Asthma 38.71 10.27 159 110969 242001 90275318
Haematocrit decreased 38.56 10.27 126 111002 41706 90475613
General physical health deterioration 38.47 10.27 266 110862 354849 90162470
Pleural effusion 37.76 10.27 251 110877 111740 90405579
Implantable defibrillator insertion 37.50 10.27 17 111111 569 90516750
Hyponatraemia 37.31 10.27 286 110842 133252 90384067
Pulmonary congestion 37.16 10.27 77 111051 19356 90497963
Nail disorder 37.11 10.27 13 111115 59054 90458265
Lower limb fracture 36.90 10.27 30 111098 84983 90432336
Myelosuppression 36.90 10.27 10 111118 53581 90463738
Hyperglycaemia 36.25 10.27 141 110987 50829 90466490
Product use in unapproved indication 35.86 10.27 253 110875 335983 90181336
Thrombosis 35.68 10.27 181 110947 73070 90444249
Brain natriuretic peptide increased 35.06 10.27 40 111088 5965 90511354
Melaena 34.99 10.27 108 111020 34689 90482630
Upper gastrointestinal haemorrhage 34.87 10.27 83 111045 22893 90494426
Platelet count decreased 34.79 10.27 287 110841 136682 90380637
Product prescribing error 34.53 10.27 98 111030 30047 90487272
Phaeochromocytoma crisis 34.36 10.27 14 111114 359 90516960
Left ventricular hypertrophy 34.32 10.27 40 111088 6104 90511215
Febrile neutropenia 34.25 10.27 91 111037 158258 90359061
Spinal epidural haematoma 34.24 10.27 21 111107 1313 90516006
Atrioventricular block first degree 34.17 10.27 47 111081 8464 90508855
Ventricular tachycardia 34.04 10.27 86 111042 24622 90492697
Obesity 33.81 10.27 48 111080 105459 90411860
Arteriosclerosis 33.56 10.27 53 111075 10800 90506519
Aortic valve incompetence 33.50 10.27 41 111087 6583 90510736
Coeliac disease 33.32 10.27 7 111121 44603 90472716
Myxoedema coma 33.01 10.27 14 111114 398 90516921
Blood potassium decreased 32.30 10.27 130 110998 47597 90469722
Blood pressure inadequately controlled 32.25 10.27 39 111089 6185 90511134
Hypoaesthesia 32.25 10.27 239 110889 313971 90203348
Pulmonary hypertension 32.19 10.27 120 111008 42403 90474916
Joint stiffness 32.09 10.27 29 111099 78013 90439306
Diastolic dysfunction 31.73 10.27 42 111086 7291 90510028
Back injury 31.54 10.27 9 111119 46613 90470706
Unevaluable event 31.40 10.27 142 110986 54706 90462613
Renal artery stenosis 31.38 10.27 24 111104 2153 90515166
Atrial flutter 31.16 10.27 51 111077 10707 90506612
Blood sodium decreased 30.89 10.27 89 111039 27524 90489795
Pneumonia 30.79 10.27 1011 110117 637048 89880271
Varices oesophageal 30.67 10.27 30 111098 3749 90513570
Serotonin syndrome 30.32 10.27 5 111123 37882 90479437
Dyspnoea exertional 30.03 10.27 171 110957 72117 90445202
Adverse event 29.77 10.27 62 111066 117356 90399963
Ventricular fibrillation 29.66 10.27 58 111070 13986 90503333
Intracardiac thrombus 29.54 10.27 24 111104 2350 90514969
Therapy cessation 29.54 10.27 105 111023 36256 90481063
Product monitoring error 29.51 10.27 32 111096 4512 90512807
Left ventricular dilatation 29.50 10.27 15 111113 650 90516669
Presyncope 29.49 10.27 96 111032 31709 90485610
Epistaxis 29.43 10.27 192 110936 84933 90432386
Gout 29.01 10.27 64 111064 16795 90500524
Metabolic acidosis 28.84 10.27 140 110988 55536 90461783
Hypertensive emergency 28.84 10.27 23 111105 2194 90515125
Electrocardiogram QT prolonged 28.54 10.27 169 110959 72287 90445032
Knee arthroplasty 28.53 10.27 36 111092 83146 90434173
Intentional overdose 28.50 10.27 205 110923 93629 90423690
Injection site reaction 28.42 10.27 43 111085 92037 90425282
Arterial stenosis 27.97 10.27 15 111113 726 90516593
Atrioventricular block complete 27.73 10.27 46 111082 9765 90507554
Torsade de pointes 27.68 10.27 59 111069 15123 90502196
Vessel puncture site haemorrhage 27.67 10.27 9 111119 118 90517201
Musculoskeletal pain 27.63 10.27 112 111016 171139 90346180
Embolic stroke 27.01 10.27 29 111099 4043 90513276
Labelled drug-drug interaction medication error 26.97 10.27 57 111071 14525 90502794
Palpitations 26.84 10.27 271 110857 136457 90380862
Bladder hypertrophy 26.48 10.27 13 111115 522 90516797
Bundle branch block left 26.47 10.27 40 111088 7845 90509474
Electrocardiogram PR shortened 26.34 10.27 13 111115 528 90516791
Drug tolerance decreased 26.25 10.27 4 111124 32126 90485193
Diabetes mellitus 25.99 10.27 152 110976 64723 90452596
Pulseless electrical activity 25.41 10.27 42 111086 8890 90508429
Azotaemia 25.28 10.27 32 111096 5316 90512003
Colitis ulcerative 25.25 10.27 22 111106 60244 90457075
Hypophagia 25.21 10.27 99 111029 35838 90481481
Prescribed underdose 25.17 10.27 33 111095 74986 90442333
N-terminal prohormone brain natriuretic peptide increased 24.95 10.27 24 111104 2938 90514381
Finger deformity 24.90 10.27 5 111123 32892 90484427
Nephrogenic anaemia 24.69 10.27 22 111106 2444 90514875
Contusion 24.40 10.27 194 110934 251022 90266297
Hypoxia 24.24 10.27 162 110966 72237 90445082
Lower gastrointestinal haemorrhage 24.21 10.27 41 111087 8851 90508468
Peripheral coldness 24.20 10.27 53 111075 13839 90503480
Liver function test increased 23.96 10.27 42 111086 84813 90432506
Renal injury 23.73 10.27 44 111084 10199 90507120
Haemorrhage 23.70 10.27 156 110972 69213 90448106
Muscle spasticity 23.56 10.27 7 111121 35315 90482004
Haematuria 23.51 10.27 95 111033 34842 90482477
Sinus node dysfunction 23.42 10.27 31 111097 5381 90511938
Ear infection 23.10 10.27 31 111097 69744 90447575
Fear 23.05 10.27 58 111070 16564 90500755
Hypokalaemia 22.98 10.27 254 110874 130862 90386457
Sepsis 22.81 10.27 328 110800 179486 90337833
Osteoporosis 22.80 10.27 53 111075 96478 90420841
Glomerulonephritis rapidly progressive 22.61 10.27 16 111112 1274 90516045
Oliguria 22.59 10.27 44 111084 10580 90506739
Pulmonary renal syndrome 22.52 10.27 12 111116 573 90516746
Peritonitis 22.51 10.27 64 111064 19641 90497678
Genotype drug resistance test positive 22.49 10.27 11 111117 438 90516881
Femoral artery dissection 22.46 10.27 6 111122 37 90517282
Abortion spontaneous 22.33 10.27 20 111108 54036 90463283
Red blood cell count decreased 22.20 10.27 114 111014 46237 90471082
Dyspepsia 22.15 10.27 147 110981 198013 90319306
Back pain 22.12 10.27 527 110601 316648 90200671
Walking aid user 21.99 10.27 8 111120 35498 90481821
Laryngitis 21.91 10.27 18 111110 50735 90466584
Urine output decreased 21.86 10.27 48 111080 12555 90504764
Immunodeficiency 21.75 10.27 13 111115 43221 90474098
Coronary artery bypass 21.64 10.27 20 111108 2329 90514990
Chronic left ventricular failure 21.55 10.27 12 111116 626 90516693
Hip fracture 21.51 10.27 89 111039 32988 90484331
Dry mouth 21.35 10.27 135 110993 183924 90333395
Frequent bowel movements 21.29 10.27 23 111105 56912 90460407
Aortic dissection 21.15 10.27 20 111108 2397 90514922
Decreased appetite 21.15 10.27 608 110520 375932 90141387
Rhabdomyolysis 21.13 10.27 121 111007 51135 90466184
Therapy non-responder 21.06 10.27 91 111037 136613 90380706
White blood cell count decreased 20.87 10.27 304 110824 166805 90350514
Cough 20.79 10.27 596 110532 368366 90148953
Platelet dysfunction 20.66 10.27 7 111121 105 90517214
Transient ischaemic attack 20.54 10.27 106 111022 43070 90474249
Urine albumin/creatinine ratio increased 20.24 10.27 11 111117 547 90516772
Prothrombin time prolonged 20.20 10.27 40 111088 9732 90507587
Loss of personal independence in daily activities 20.13 10.27 92 111036 136013 90381306
Electrocardiogram abnormal 19.92 10.27 41 111087 10257 90507062
Low cardiac output syndrome 19.89 10.27 10 111118 423 90516896
Diabetes mellitus inadequate control 19.73 10.27 59 111069 18625 90498694
Macular degeneration 19.69 10.27 11 111117 37959 90479360
Feeling abnormal 19.63 10.27 301 110827 166934 90350385
Adverse reaction 19.62 10.27 6 111122 29706 90487613
Basal ganglia haemorrhage 19.58 10.27 12 111116 749 90516570
Cardiac tamponade 19.52 10.27 29 111099 5603 90511716
Disability 19.47 10.27 13 111115 40732 90476587
Haematoma 19.37 10.27 97 111031 38951 90478368
Acidosis 19.31 10.27 46 111082 12690 90504629
Arthritis 19.26 10.27 123 111005 167192 90350127
Joint dislocation 19.01 10.27 16 111112 44566 90472753
Stress cardiomyopathy 18.93 10.27 47 111081 13308 90504011
Occult blood positive 18.91 10.27 24 111104 3999 90513320
Skin discolouration 18.52 10.27 105 111023 44210 90473109
Subarachnoid haemorrhage 18.40 10.27 56 111072 17848 90499471
Vascular stent stenosis 18.27 10.27 11 111117 665 90516654
Transfusion 18.25 10.27 55 111073 17433 90499886
Cardiotoxicity 18.22 10.27 42 111086 11347 90505972
Metabolic encephalopathy 18.21 10.27 31 111097 6721 90510598
Gastritis erosive 18.20 10.27 31 111097 6724 90510595
Gastritis 18.16 10.27 100 111028 41653 90475666
Herbal interaction 18.01 10.27 7 111121 158 90517161
Peripheral vascular disorder 17.97 10.27 30 111098 6401 90510918
Vitreous haemorrhage 17.95 10.27 19 111109 2607 90514712
Catheterisation cardiac 17.87 10.27 26 111102 4930 90512389
Cardiac valve disease 17.72 10.27 25 111103 4610 90512709
Cardiac operation 17.68 10.27 23 111105 3926 90513393
Toxic neuropathy 17.67 10.27 10 111118 538 90516781
Renal atrophy 17.54 10.27 16 111112 1832 90515487
Hospitalisation 17.18 10.27 236 110892 127864 90389455
Hypertensive encephalopathy 17.15 10.27 11 111117 744 90516575
Electrocardiogram ST segment 17.12 10.27 3 111125 0 90517319
Ventricular extrasystoles 17.10 10.27 45 111083 13205 90504114
Food allergy 17.08 10.27 5 111123 25473 90491846
Uraemic encephalopathy 17.03 10.27 8 111120 291 90517028
Subdural haemorrhage 17.01 10.27 21 111107 3402 90513917
Shunt occlusion 16.89 10.27 11 111117 764 90516555
Hospice care 16.88 10.27 37 111091 9667 90507652
Faeces discoloured 16.83 10.27 61 111067 21259 90496060
Refractory anaemia with an excess of blasts 16.81 10.27 9 111119 434 90516885
Electrocardiogram QT shortened 16.81 10.27 7 111121 190 90517129
Ear pain 16.81 10.27 28 111100 57674 90459645
Supraventricular extrasystoles 16.71 10.27 26 111102 5231 90512088
Urine glucose/creatinine ratio increased 16.64 10.27 7 111121 195 90517124
Chest discomfort 16.60 10.27 250 110878 138115 90379204
Blood creatine phosphokinase increased 16.52 10.27 84 111044 33939 90483380
Diverticulum 16.51 10.27 42 111086 12071 90505248
Renin increased 16.47 10.27 7 111121 200 90517119
Mucocutaneous haemorrhage 16.40 10.27 6 111122 114 90517205
Weight increased 16.30 10.27 389 110739 417538 90099781
Nausea 16.29 10.27 1576 109552 1108740 89408579
Pulmonary arterial pressure increased 16.29 10.27 22 111106 3894 90513425
Hydrothorax 16.25 10.27 12 111116 1021 90516298
Coagulopathy 16.21 10.27 64 111064 23225 90494094
Corneal disorder 16.18 10.27 16 111112 2026 90515293
Respiratory distress 16.09 10.27 92 111036 38854 90478465
Vision blurred 15.95 10.27 206 110922 110087 90407232
Haemorrhoids 15.94 10.27 70 111058 26632 90490687
Pernicious anaemia 15.89 10.27 11 111117 845 90516474
Hydronephrosis 15.88 10.27 42 111086 12360 90504959
Cardiac pacemaker insertion 15.72 10.27 23 111105 4384 90512935
Hyphaema 15.49 10.27 8 111120 358 90516961
Paraplegia 15.48 10.27 20 111108 3392 90513927
Nephrogenic systemic fibrosis 15.47 10.27 22 111106 4086 90513233
Angioedema 15.44 10.27 134 110994 64742 90452577
Diabetic foot infection 15.18 10.27 7 111121 244 90517075
Dry skin 15.14 10.27 170 110958 87903 90429416
Gastric ulcer haemorrhage 15.14 10.27 25 111103 5286 90512033
Concomitant disease progression 14.99 10.27 16 111112 2216 90515103
Hypouricaemia 14.84 10.27 7 111121 257 90517062
Intercepted product dispensing error 14.76 10.27 6 111122 153 90517166
Pancytopenia 14.70 10.27 218 110910 120045 90397274
Drug ineffective for unapproved indication 14.63 10.27 38 111090 66606 90450713
Gastrointestinal arteriovenous malformation 14.63 10.27 9 111119 566 90516753
Vascular pseudoaneurysm 14.59 10.27 14 111114 1709 90515610
Hepatic cytolysis 14.59 10.27 10 111118 30906 90486413
Breast cancer recurrent 14.49 10.27 25 111103 5478 90511841
Aortic stenosis 14.40 10.27 27 111101 6309 90511010
Carcinoembryonic antigen increased 14.31 10.27 16 111112 2334 90514985
Long QT syndrome 14.30 10.27 21 111107 4016 90513303
Electrocardiogram T wave inversion 14.28 10.27 20 111108 3663 90513656
Gait inability 14.26 10.27 113 111015 146343 90370976
Diarrhoea infectious 14.24 10.27 12 111116 1237 90516082
Cognitive disorder 14.17 10.27 41 111087 69366 90447953
Delirium 14.00 10.27 73 111055 104286 90413033
Nodal rhythm 13.95 10.27 14 111114 1804 90515515
Lupus-like syndrome 13.95 10.27 24 111104 48822 90468497
Colon cancer 13.95 10.27 37 111091 10907 90506412
Renal hypoplasia 13.91 10.27 5 111123 90 90517229
Hepatocellular carcinoma 13.88 10.27 16 111112 2412 90514907
Insulin-requiring type 2 diabetes mellitus 13.86 10.27 5 111123 91 90517228
Cholestatic liver injury 13.81 10.27 20 111108 3777 90513542
Paraesthesia 13.71 10.27 220 110908 250106 90267213
Abdominal pain upper 13.71 10.27 307 110821 332367 90184952
Device expulsion 13.70 10.27 18 111110 40868 90476451
Oral cavity fistula 13.69 10.27 9 111119 635 90516684
Hypoacusis 13.69 10.27 69 111059 27781 90489538
Tachypnoea 13.59 10.27 57 111071 21252 90496067
Pericardial haemorrhage 13.59 10.27 14 111114 1862 90515457
Heart rate decreased 13.52 10.27 112 111016 53393 90463926
Exostosis 13.51 10.27 28 111100 53106 90464213
Hypovolaemic shock 13.43 10.27 28 111100 7066 90510253
Amnesia 13.41 10.27 78 111050 108427 90408892
Leukocyturia 13.40 10.27 13 111115 1609 90515710
Exercise tolerance decreased 13.37 10.27 29 111099 7522 90509797
Left ventricular failure 13.34 10.27 27 111101 6673 90510646
Product residue present 13.33 10.27 21 111107 4270 90513049
Foetal exposure during pregnancy 13.32 10.27 20 111108 42955 90474364
Haemorrhagic erosive gastritis 13.18 10.27 8 111120 491 90516828
Affect lability 13.15 10.27 3 111125 18060 90499259
Inappropriate antidiuretic hormone secretion 13.09 10.27 53 111075 19452 90497867
Breath sounds 13.07 10.27 5 111123 108 90517211
Basal cell carcinoma 13.03 10.27 13 111115 33376 90483943
Blood aldosterone abnormal 13.02 10.27 4 111124 43 90517276
Traumatic renal injury 12.97 10.27 3 111125 9 90517310
Heart sounds abnormal 12.95 10.27 9 111119 696 90516623
Female genital tract fistula 12.95 10.27 3 111125 17865 90499454
Taste disorder 12.83 10.27 36 111092 61510 90455809
Confusional state 12.80 10.27 368 110760 385837 90131482
Carbohydrate antigen 15-3 increased 12.80 10.27 14 111114 1993 90515326
Gastric ulcer 12.79 10.27 67 111061 27381 90489938
Diverticulum intestinal 12.78 10.27 32 111096 9110 90508209
Clostridium difficile infection 12.68 10.27 82 111046 36163 90481156
Diabetic nephropathy 12.67 10.27 13 111115 1721 90515598
Haemodialysis 12.63 10.27 31 111097 8716 90508603
Incorrect route of product administration 12.60 10.27 27 111101 50599 90466720
Ischaemia 12.59 10.27 23 111105 5272 90512047
Liver disorder 12.54 10.27 92 111036 121177 90396142
Epinephrine increased 12.51 10.27 3 111125 11 90517308
Necrotising retinitis 12.48 10.27 8 111120 541 90516778
Carotid artery stenosis 12.46 10.27 23 111105 5311 90512008
Paresis 12.45 10.27 16 111112 2698 90514621
Electrocardiogram QRS complex shortened 12.44 10.27 8 111120 544 90516775
Thalamus haemorrhage 12.42 10.27 9 111119 744 90516575
Morbid thoughts 12.41 10.27 9 111119 745 90516574
Right aortic arch 12.34 10.27 6 111122 236 90517083
Diabetic neuropathy 12.33 10.27 21 111107 4553 90512766
Anti-erythropoietin antibody positive 12.33 10.27 7 111121 379 90516940
Hyperparathyroidism secondary 12.25 10.27 13 111115 1788 90515531
Headache 12.21 10.27 902 110226 861844 89655475
Sinoatrial block 12.17 10.27 10 111118 995 90516324
Bradyarrhythmia 12.07 10.27 15 111113 2446 90514873
Essential hypertension 12.05 10.27 25 111103 6290 90511029
Sudden death 12.04 10.27 35 111093 10874 90506445
Sinus arrest 12.03 10.27 14 111114 2132 90515187
Cerebral haemorrhage 12.01 10.27 78 111050 34444 90482875
Drug dependence 11.93 10.27 11 111117 29316 90488003
Iron deficiency anaemia 11.89 10.27 59 111069 23603 90493716
Arteriovenous fistula thrombosis 11.86 10.27 6 111122 257 90517062
Nodal arrhythmia 11.82 10.27 11 111117 1292 90516027
Acute pulmonary oedema 11.82 10.27 32 111096 9548 90507771
Pustular psoriasis 11.80 10.27 4 111124 18552 90498767
Renal tubular necrosis 11.79 10.27 42 111086 14513 90502806
Hepatotoxicity 11.79 10.27 24 111104 45818 90471501
Fatigue 11.75 10.27 1600 109528 1152423 89364896
Heart transplant 11.67 10.27 8 111120 605 90516714
Quadriplegia 11.59 10.27 14 111114 2217 90515102
Sudden cardiac death 11.59 10.27 14 111114 2218 90515101
Ascites 11.56 10.27 99 111029 47641 90469678
Poisoning deliberate 11.49 10.27 3 111125 16483 90500836
Small intestinal haemorrhage 11.39 10.27 14 111114 2257 90515062
Extrapyramidal disorder 11.30 10.27 3 111125 16300 90501019
Hepatic vein dilatation 11.30 10.27 3 111125 18 90517301
Scratch 11.23 10.27 32 111096 9834 90507485
Flatulence 11.21 10.27 88 111040 41279 90476040
Drug tolerance 11.16 10.27 4 111124 17912 90499407
Drug-induced liver injury 11.12 10.27 65 111063 90253 90427066
Leukopenia 11.10 10.27 75 111053 100635 90416684
Hypercapnia 11.10 10.27 25 111103 6652 90510667
Neck pain 11.06 10.27 88 111040 113875 90403444
Anticoagulation drug level above therapeutic 11.02 10.27 13 111115 2009 90515310
Retinopathy hypertensive 10.95 10.27 6 111122 303 90517016
Dizziness postural 10.93 10.27 30 111098 9023 90508296
Blood parathyroid hormone increased 10.93 10.27 17 111111 3420 90513899
Dilatation ventricular 10.89 10.27 14 111114 2362 90514957
Ectopic ACTH syndrome 10.88 10.27 5 111123 173 90517146
Left ventricular enlargement 10.83 10.27 4 111124 78 90517241
Foetal death 10.75 10.27 6 111122 20717 90496602
Blindness unilateral 10.73 10.27 27 111101 7709 90509610
Hyperlipidaemia 10.72 10.27 56 111072 22860 90494459
Respiratory disorder 10.70 10.27 42 111086 64774 90452545
Sluggishness 10.68 10.27 23 111105 5936 90511383
Malnutrition 10.59 10.27 48 111080 18510 90498809
Electrocardiogram QRS complex prolonged 10.57 10.27 26 111102 7322 90509997
Nephropathy 10.55 10.27 30 111098 9205 90508114
Injection site erythema 10.54 10.27 74 111054 98428 90418891
Deafness 10.52 10.27 55 111073 22459 90494860
Troponin increased 10.49 10.27 38 111090 13243 90504076
Haematochezia 10.49 10.27 133 110995 70780 90446539
Heart rate irregular 10.47 10.27 58 111070 24210 90493109
Glomerulonephritis 10.46 10.27 14 111114 2456 90514863
Aplasia pure red cell 10.43 10.27 21 111107 5173 90512146
Gingival bleeding 10.41 10.27 41 111087 14862 90502457

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 1245.31 10.85 1410 127338 84192 42408395
Hypotension 535.55 10.85 1851 126897 255780 42236807
Cardiac failure 514.57 10.85 1051 127697 105805 42386782
Myocardial infarction 485.63 10.85 1122 127626 122887 42369700
Bradycardia 377.70 10.85 812 127936 84672 42407915
Off label use 267.13 10.85 1012 127736 637323 41855264
Hyperkalaemia 207.99 10.85 624 128124 79834 42412753
Ejection fraction decreased 207.47 10.85 293 128455 21794 42470793
Acute myocardial infarction 190.70 10.85 492 128256 57673 42434914
Cardiac failure chronic 186.90 10.85 185 128563 9416 42483171
Completed suicide 181.47 10.85 672 128076 95793 42396794
Coronary artery disease 180.87 10.85 459 128289 53261 42439326
BRASH syndrome 172.50 10.85 92 128656 1733 42490854
Febrile neutropenia 164.72 10.85 191 128557 185512 42307075
Syncope 163.72 10.85 664 128084 98742 42393845
Ischaemic cardiomyopathy 162.20 10.85 144 128604 6378 42486209
Drug abuse 158.64 10.85 59 128689 104712 42387875
Dizziness 156.46 10.85 1286 127462 247968 42244619
Drug ineffective 154.68 10.85 1194 127554 629003 41863584
Mitral valve incompetence 152.28 10.85 217 128531 16272 42476315
Blood pressure decreased 151.24 10.85 453 128295 57879 42434708
Ventricular tachycardia 133.58 10.85 287 128461 29873 42462714
Dyspnoea 129.01 10.85 1962 126786 440659 42051928
Atrial fibrillation 127.54 10.85 789 127959 138804 42353783
Chronic kidney disease 125.42 10.85 370 128378 46871 42445716
Neutropenia 124.41 10.85 260 128488 199171 42293416
Cardiomyopathy 120.80 10.85 212 128536 18998 42473589
Pyrexia 108.71 10.85 721 128027 393321 42099266
Gastrointestinal haemorrhage 104.53 10.85 576 128172 97150 42395437
Cardiac disorder 103.15 10.85 354 128394 48578 42444009
International normalised ratio increased 102.87 10.85 350 128398 47818 42444769
Foetal exposure during pregnancy 101.25 10.85 12 128736 47299 42445288
Cardiac failure acute 98.39 10.85 160 128588 13473 42479114
Pulmonary oedema 95.83 10.85 366 128382 52906 42439681
Blood creatinine increased 94.97 10.85 613 128135 109390 42383197
Blood potassium increased 89.78 10.85 183 128565 18353 42474234
Product use in unapproved indication 87.61 10.85 276 128472 184180 42308407
Treatment failure 85.56 10.85 41 128707 62583 42430004
Presyncope 80.26 10.85 196 128552 22191 42470396
Cardiomegaly 79.40 10.85 164 128584 16602 42475985
Renal impairment 76.21 10.85 582 128166 109646 42382941
Fluid retention 74.89 10.85 238 128510 31381 42461206
Ventricular hypokinesia 74.74 10.85 98 128650 6786 42485801
Cerebrovascular accident 71.69 10.85 521 128227 96639 42395948
Tricuspid valve incompetence 71.63 10.85 124 128624 10989 42481598
Oedema peripheral 71.12 10.85 675 128073 135401 42357186
Acute kidney injury 70.53 10.85 1526 127222 365811 42126776
Bundle branch block left 70.02 10.85 92 128656 6384 42486203
Myelosuppression 69.79 10.85 18 128730 40443 42452144
Shock 66.97 10.85 217 128531 28904 42463683
Chest pain 66.52 10.85 679 128069 138851 42353736
Mucosal inflammation 64.93 10.85 34 128714 49340 42443247
Left ventricular dilatation 64.71 10.85 38 128710 868 42491719
Sinus bradycardia 63.08 10.85 139 128609 14714 42477873
Nipple swelling 61.42 10.85 28 128720 369 42492218
Congestive cardiomyopathy 60.73 10.85 101 128647 8663 42483924
Orthopnoea 60.19 10.85 78 128670 5339 42487248
Atrioventricular block 59.01 10.85 105 128643 9510 42483077
Cardiac arrest 58.45 10.85 545 128203 108775 42383812
Intentional product use issue 56.24 10.85 81 128667 71752 42420835
Hypoglycaemia 55.62 10.85 340 128408 59514 42433073
Coronary arterial stent insertion 54.98 10.85 64 128684 3921 42488666
Coronary artery bypass 54.60 10.85 70 128678 4740 42487847
Leukopenia 52.16 10.85 91 128657 74655 42417932
Computerised tomogram coronary artery abnormal 52.07 10.85 19 128729 134 42492453
Therapeutic product effect incomplete 51.69 10.85 84 128664 70855 42421732
Cardioactive drug level increased 50.61 10.85 42 128706 1695 42490892
N-terminal prohormone brain natriuretic peptide increased 50.24 10.85 57 128691 3396 42489191
Drug dependence 50.06 10.85 13 128735 29081 42463506
Product monitoring error 49.63 10.85 64 128684 4359 42488228
Death 49.40 10.85 1812 126936 469373 42023214
Orthostatic hypotension 49.29 10.85 203 128545 30367 42462220
Left ventricular dysfunction 49.26 10.85 108 128640 11393 42481194
Asthenia 49.23 10.85 1152 127596 279641 42212946
Glomerular filtration rate decreased 49.16 10.85 134 128614 16217 42476370
Suicidal ideation 48.90 10.85 44 128704 48117 42444470
Blood urea increased 47.65 10.85 211 128537 32582 42460005
Renal failure 47.06 10.85 651 128097 143075 42349512
N-terminal prohormone brain natriuretic peptide abnormal 46.99 10.85 20 128728 221 42492366
Renal cyst haemorrhage 46.82 10.85 28 128720 662 42491925
Cardio-respiratory arrest 46.47 10.85 320 128428 58316 42434271
Nipple pain 46.44 10.85 33 128715 1054 42491533
Carotid arteriosclerosis 45.50 10.85 45 128703 2287 42490300
Fall 45.43 10.85 976 127772 233544 42259043
Angina pectoris 45.06 10.85 208 128540 32688 42459899
Malignant neoplasm progression 44.80 10.85 172 128576 108228 42384359
Sedation 44.70 10.85 18 128730 30457 42462130
Hypervolaemia 43.32 10.85 161 128587 22964 42469623
Pericardial disease 42.92 10.85 24 128724 498 42492089
Diastolic dysfunction 42.52 10.85 76 128672 6907 42485680
Suspected suicide 42.36 10.85 71 128677 6128 42486459
Pulmonary valve disease 41.99 10.85 22 128726 399 42492188
Agitation 41.60 10.85 82 128666 64232 42428355
Drug reaction with eosinophilia and systemic symptoms 40.88 10.85 40 128708 42035 42450552
Pulmonary embolism 40.80 10.85 204 128544 119408 42373179
Left ventricular hypertrophy 40.47 10.85 88 128660 9231 42483356
Blood loss anaemia 40.09 10.85 90 128658 9646 42482941
Peritonitis bacterial 39.24 10.85 73 128675 6842 42485745
Neutrophil count decreased 39.19 10.85 83 128665 63332 42429255
Thrombocytopenia 38.94 10.85 377 128371 189902 42302685
Mitral valve disease 38.86 10.85 34 128714 1476 42491111
Hyperparathyroidism secondary 38.67 10.85 37 128711 1805 42490782
Rheumatoid arthritis 38.26 10.85 43 128705 42397 42450190
Carotid artery stenosis 38.14 10.85 63 128685 5373 42487214
Intentional dose omission 38.05 10.85 84 128664 8902 42483685
Blood pressure inadequately controlled 37.81 10.85 45 128703 2823 42489764
Cardiac discomfort 37.69 10.85 25 128723 712 42491875
Hepatic cytolysis 37.55 10.85 17 128731 26827 42465760
Large intestine polyp 37.43 10.85 85 128663 9180 42483407
Loss of personal independence in daily activities 37.22 10.85 58 128690 49758 42442829
Aortic valve incompetence 37.00 10.85 69 128679 6479 42486108
Dyspnoea at rest 36.43 10.85 54 128694 4195 42488392
Drug resistance 36.34 10.85 30 128718 34218 42458369
Dyspnoea exertional 35.86 10.85 267 128481 49881 42442706
Pulse pressure increased 35.66 10.85 9 128739 12 42492575
Carotid sinus syndrome 35.60 10.85 10 128738 25 42492562
Pulmonary hypertension 35.27 10.85 153 128595 23416 42469171
Condition aggravated 35.14 10.85 565 128183 260189 42232398
Electrocardiogram Q wave abnormal 34.51 10.85 21 128727 513 42492074
Type V hyperlipidaemia 33.93 10.85 26 128722 934 42491653
Rash 33.79 10.85 611 128137 276343 42216244
Generalised tonic-clonic seizure 33.46 10.85 19 128729 26360 42466227
Electrocardiogram abnormal 33.40 10.85 86 128662 10059 42482528
Rectal prolapse 33.32 10.85 21 128727 547 42492040
Nephrogenic anaemia 33.15 10.85 40 128708 2546 42490041
Pancytopenia 33.03 10.85 214 128534 117529 42375058
Blood glucose decreased 32.72 10.85 106 128642 14113 42478474
Conduction disorder 32.36 10.85 39 128709 2479 42490108
Fractured coccyx 32.32 10.85 14 128734 162 42492425
Brain natriuretic peptide abnormal 32.26 10.85 18 128730 372 42492215
Cardiogenic shock 32.18 10.85 201 128547 35439 42457148
Intentional self-injury 32.17 10.85 4 128744 15198 42477389
Jugular vein distension 32.11 10.85 22 128726 662 42491925
Physical examination abnormal 32.05 10.85 19 128729 442 42492145
Blood glucose increased 31.96 10.85 352 128396 73347 42419240
Premature baby 31.86 10.85 15 128733 23138 42469449
Fatigue 31.81 10.85 1614 127134 434027 42058560
Lower respiratory tract infection 31.72 10.85 47 128701 41159 42451428
Cerebral infarction 31.48 10.85 181 128567 30988 42461599
Glycosylated haemoglobin increased 31.25 10.85 98 128650 12826 42479761
Cytokine release syndrome 31.25 10.85 54 128694 44473 42448114
Erythema 30.89 10.85 197 128551 108596 42383991
Arrhythmia 30.75 10.85 218 128530 40099 42452488
Ventricular internal diameter abnormal 30.74 10.85 14 128734 184 42492403
Musculoskeletal stiffness 30.60 10.85 82 128666 57683 42434904
Aggression 30.59 10.85 54 128694 44109 42448478
Appendicitis 30.52 10.85 12 128736 20601 42471986
Ventricular arrhythmia 30.41 10.85 62 128686 6217 42486370
Sinus arrest 30.37 10.85 35 128713 2121 42490466
Blood iron decreased 30.14 10.85 62 128686 6256 42486331
Ventricular dysfunction 30.01 10.85 51 128697 4452 42488135
Rales 29.96 10.85 89 128659 11311 42481276
Coma 29.93 10.85 74 128674 53480 42439107
Cytomegalovirus infection 29.92 10.85 32 128716 32274 42460313
Heart rate decreased 29.91 10.85 201 128547 36331 42456256
Injection site pain 29.91 10.85 83 128665 57715 42434872
Hepatojugular reflux 29.90 10.85 21 128727 658 42491929
Lymphopenia 29.62 10.85 14 128734 21549 42471038
Myocardial ischaemia 29.46 10.85 119 128629 17643 42474944
Nodal rhythm 29.34 10.85 30 128718 1587 42491000
Dialysis 29.09 10.85 91 128657 11895 42480692
Therapy partial responder 29.08 10.85 12 128736 20009 42472578
Nodal arrhythmia 28.86 10.85 23 128725 876 42491711
Glomerular filtration rate abnormal 28.49 10.85 26 128722 1194 42491393
Disease progression 28.37 10.85 287 128461 143369 42349218
Renal artery stenosis 28.34 10.85 35 128713 2282 42490305
Sudden cardiac death 28.24 10.85 46 128702 3878 42488709
Candida infection 28.23 10.85 15 128733 21595 42470992
Systolic dysfunction 28.17 10.85 40 128708 2988 42489599
Drug ineffective for unapproved indication 28.04 10.85 61 128687 46102 42446485
Mouth breathing 27.93 10.85 11 128737 98 42492489
Angina unstable 27.86 10.85 87 128661 11361 42481226
Gallbladder oedema 27.53 10.85 14 128734 238 42492349
Aspergillus infection 27.39 10.85 7 128741 15830 42476757
Suicide attempt 27.11 10.85 62 128686 46038 42446549
Depression 27.04 10.85 211 128537 111152 42381435
Neutrophil count increased 26.99 10.85 13 128735 19791 42472796
Therapeutic drug monitoring analysis incorrectly performed 26.88 10.85 15 128733 310 42492277
Tumour lysis syndrome 26.81 10.85 17 128731 22214 42470373
Vena cava injury 26.09 10.85 15 128733 329 42492258
Haemorrhage intracranial 26.02 10.85 112 128636 17080 42475507
Myocardial necrosis 25.95 10.85 14 128734 270 42492317
Bradyarrhythmia 25.87 10.85 36 128712 2639 42489948
No adverse event 25.80 10.85 204 128544 38817 42453770
Primary hyperaldosteronism 25.18 10.85 12 128736 176 42492411
Abdominal wall haemorrhage 25.12 10.85 17 128731 501 42492086
Neuroleptic malignant syndrome 25.11 10.85 17 128731 21455 42471132
Dehydration 24.88 10.85 582 128166 141185 42351402
Vascular anastomotic haemorrhage 24.68 10.85 14 128734 299 42492288
Somnolence 24.63 10.85 290 128458 140815 42351772
Alanine aminotransferase increased 24.12 10.85 162 128586 88244 42404343
Cholestasis 23.88 10.85 39 128709 32840 42459747
SARS-CoV-2 antibody test positive 23.85 10.85 15 128733 389 42492198
Echocardiogram abnormal 23.84 10.85 24 128724 1246 42491341
Lymphadenopathy 23.84 10.85 40 128708 33325 42459262
Graft versus host disease 23.77 10.85 5 128743 12920 42479667
Oedema 23.76 10.85 251 128497 51750 42440837
Pulmonary arterial pressure abnormal 23.60 10.85 14 128734 326 42492261
Atrioventricular block first degree 23.44 10.85 57 128691 6434 42486153
Hypertensive crisis 23.41 10.85 76 128672 10130 42482457
Respiratory depression 23.35 10.85 14 128734 18854 42473733
Bone marrow failure 23.34 10.85 40 128708 33053 42459534
Cerebral haemorrhage 23.23 10.85 199 128549 38767 42453820
Concomitant disease progression 23.19 10.85 33 128715 2470 42490117
Rhabdoid tumour 23.07 10.85 7 128741 25 42492562
Epilepsy 23.06 10.85 27 128721 26144 42466443
Diverticulum intestinal 23.02 10.85 49 128699 5064 42487523
Occult blood 23.00 10.85 21 128727 965 42491622
Nightmare 22.92 10.85 25 128723 24987 42467600
Bronchiectasis 22.82 10.85 13 128735 18006 42474581
Coronary artery stenosis 22.65 10.85 76 128672 10303 42482284
Seizure 22.52 10.85 244 128504 120317 42372270
Vomiting 22.49 10.85 685 128063 289038 42203549
Rash maculo-papular 22.41 10.85 50 128698 37453 42455134
Haemoglobin decreased 22.38 10.85 541 128207 131930 42360657
Infusion related reaction 22.30 10.85 101 128647 60705 42431882
Oxygen saturation increased 22.29 10.85 13 128735 293 42492294
Progressive multifocal leukoencephalopathy 22.19 10.85 4 128744 11532 42481055
Pathogen resistance 21.96 10.85 4 128744 11446 42481141
Electrocardiogram QRS complex abnormal 21.93 10.85 15 128733 450 42492137
Bronchopulmonary aspergillosis 21.90 10.85 16 128732 19413 42473174
Anti-neutrophil cytoplasmic antibody positive vasculitis 21.85 10.85 25 128723 1503 42491084
Dizziness postural 21.58 10.85 62 128686 7733 42484854
Eczema 21.57 10.85 44 128704 34042 42458545
Migraine 21.57 10.85 27 128721 25387 42467200
Urticaria 21.56 10.85 133 128615 73903 42418684
Sinus node dysfunction 21.53 10.85 46 128702 4766 42487821
Akathisia 21.51 10.85 3 128745 10448 42482139
Drug withdrawal syndrome 21.50 10.85 20 128728 21529 42471058
Oesophageal discomfort 21.35 10.85 9 128739 97 42492490
Blood thyroid stimulating hormone abnormal 21.32 10.85 14 128734 392 42492195
Drug use disorder 21.19 10.85 3 128745 10330 42482257
Helicobacter test false negative 21.06 10.85 8 128740 64 42492523
Pulmonary fibrosis 20.96 10.85 30 128718 26651 42465936
Blood pressure increased 20.92 10.85 428 128320 101500 42391087
Brain natriuretic peptide increased 20.87 10.85 56 128692 6714 42485873
Bundle branch block 20.66 10.85 20 128728 990 42491597
Extrapyramidal disorder 20.56 10.85 12 128736 16400 42476187
Polyp 20.52 10.85 44 128704 4570 42488017
Arthralgia 20.46 10.85 468 128280 204770 42287817
Infection 20.46 10.85 228 128520 111840 42380747
Blood pressure systolic decreased 20.42 10.85 46 128702 4941 42487646
Tinnitus 20.39 10.85 35 128713 28903 42463684
Asthma 20.26 10.85 108 128640 62206 42430381
Azotaemia 20.20 10.85 51 128697 5893 42486694
Coronary artery occlusion 20.12 10.85 76 128672 10921 42481666
Aortic dilatation 20.07 10.85 25 128723 1644 42490943
Frequent bowel movements 20.05 10.85 21 128727 21386 42471201
Vascular graft 19.83 10.85 24 128724 1532 42491055
Concomitant disease aggravated 19.82 10.85 54 128694 6532 42486055
Agranulocytosis 19.81 10.85 39 128709 30573 42462014
Impaired quality of life 19.79 10.85 9 128739 14168 42478419
Intentional product misuse 19.73 10.85 108 128640 61792 42430795
Hyperuricaemia 19.68 10.85 68 128680 9356 42483231
Mitral valve calcification 19.68 10.85 16 128732 627 42491960
Vasculitis 19.65 10.85 16 128732 18378 42474209
Miosis 19.62 10.85 8 128740 13438 42479149
COVID-19 19.58 10.85 240 128508 115708 42376879
Epstein-Barr virus infection 19.52 10.85 3 128745 9715 42482872
Drug hypersensitivity 19.43 10.85 199 128549 99190 42393397
Disturbance in attention 19.37 10.85 38 128710 29828 42462759
Perineal cyst 19.35 10.85 11 128737 236 42492351
Vascular compression 19.27 10.85 13 128735 381 42492206
Hepatitis 19.25 10.85 33 128715 27267 42465320
Hypophosphataemia 19.12 10.85 21 128727 20924 42471663
Psychotic disorder 19.09 10.85 37 128711 29171 42463416
Arterial spasm 19.07 10.85 8 128740 85 42492502
Prostate cancer 18.97 10.85 70 128678 44573 42448014
Toxicity to various agents 18.95 10.85 537 128211 228599 42263988
Subdural haematoma 18.75 10.85 127 128621 23011 42469576
Hemiparaesthesia 18.72 10.85 10 128738 189 42492398
Mouth ulceration 18.66 10.85 11 128737 14952 42477635
Ventricular extrasystoles 18.58 10.85 85 128663 13305 42479282
Aortic arteriosclerosis 18.53 10.85 45 128703 5075 42487512
Left atrial dilatation 18.44 10.85 29 128719 2373 42490214
Left atrial enlargement 18.41 10.85 19 128729 1016 42491571
Drug intolerance 18.32 10.85 155 128593 80269 42412318
Hepatocellular injury 18.23 10.85 27 128721 23651 42468936
Upper gastrointestinal haemorrhage 18.20 10.85 155 128593 30144 42462443
Pneumocystis jirovecii pneumonia 18.16 10.85 30 128718 25151 42467436
Melaena 18.16 10.85 188 128560 38558 42454029
Neurological symptom 18.10 10.85 4 128744 9987 42482600
Full blood count decreased 17.97 10.85 115 128633 20445 42472142
Rhinitis 17.69 10.85 7 128741 11970 42480617
Drug interaction 17.56 10.85 980 127768 266019 42226568
Hypergastrinaemia 17.53 10.85 10 128738 216 42492371
Cytomegalovirus infection reactivation 17.40 10.85 6 128742 11172 42481415
Oral candidiasis 17.39 10.85 11 128737 14394 42478193
Substance abuse 17.32 10.85 3 128745 8902 42483685
Colitis ulcerative 17.24 10.85 33 128715 26142 42466445
Inflammation 17.21 10.85 49 128699 33798 42458789
C-reactive protein increased 17.07 10.85 117 128631 63443 42429144
Hyperphosphataemia 17.02 10.85 9 128739 12995 42479592
Stenosis 17.01 10.85 26 128722 2075 42490512
Pulse waveform abnormal 16.99 10.85 4 128744 3 42492584
Sleep disorder 16.98 10.85 81 128667 48014 42444573
Mitral valve thickening 16.97 10.85 13 128735 467 42492120
Haemophagocytic lymphohistiocytosis 16.93 10.85 18 128730 18204 42474383
Full blood count abnormal 16.91 10.85 41 128707 29835 42462752
Heart valve stenosis 16.89 10.85 7 128741 72 42492515
Intracardiac thrombus 16.81 10.85 28 128720 2404 42490183
Bacterial infection 16.79 10.85 37 128711 27842 42464745
Oesophageal varices haemorrhage 16.74 10.85 35 128713 3572 42489015
Intraductal papillary mucinous neoplasm 16.70 10.85 13 128735 478 42492109
Osteonecrosis 16.70 10.85 14 128734 15851 42476736
Multiple organ dysfunction syndrome 16.70 10.85 200 128548 96835 42395752
Atrial flutter 16.65 10.85 99 128649 17152 42475435
Tremor 16.60 10.85 200 128548 96729 42395858
Immune reconstitution inflammatory syndrome 16.58 10.85 5 128743 10138 42482449
Ejection fraction abnormal 16.55 10.85 20 128728 1275 42491312
Acute generalised exanthematous pustulosis 16.49 10.85 3 128745 8592 42483995
Atrioventricular block second degree 16.45 10.85 38 128710 4149 42488438
Atrioventricular block complete 16.41 10.85 73 128675 11291 42481296
Impaired work ability 16.38 10.85 8 128740 12083 42480504
Gravitational oedema 16.36 10.85 15 128733 693 42491894
Implantable defibrillator insertion 16.29 10.85 16 128732 806 42491781
Cardiac output decreased 16.21 10.85 18 128730 1047 42491540
Klebsiella infection 16.12 10.85 7 128741 11325 42481262
Blood 25-hydroxycholecalciferol decreased 16.02 10.85 11 128737 332 42492255
Rash erythematous 15.92 10.85 47 128701 32044 42460543
Supraventricular tachycardia 15.92 10.85 77 128671 12331 42480256
Pelvic neoplasm 15.79 10.85 6 128742 48 42492539
Transaminases increased 15.72 10.85 49 128699 32836 42459751
Pain 15.69 10.85 593 128155 244255 42248332
Cardiac pacemaker insertion 15.64 10.85 32 128716 3216 42489371
Anger 15.64 10.85 10 128738 13008 42479579
Cardioactive drug level above therapeutic 15.48 10.85 6 128742 51 42492536
Neurotoxicity 15.42 10.85 30 128718 23621 42468966
Chronic left ventricular failure 15.42 10.85 15 128733 747 42491840
Torsade de pointes 15.40 10.85 59 128689 8535 42484052
Low cardiac output syndrome 15.39 10.85 14 128734 640 42491947
Hallucination 15.37 10.85 106 128642 57401 42435186
Haematotoxicity 15.29 10.85 7 128741 10978 42481609
Stress 15.29 10.85 75 128673 44137 42448450
Stent placement 15.19 10.85 43 128705 5317 42487270
Wheezing 15.13 10.85 100 128648 54681 42437906
Hypoglycaemic unconsciousness 15.06 10.85 15 128733 769 42491818
Serotonin syndrome 15.00 10.85 35 128713 25810 42466777
Aspartate aminotransferase increased 14.87 10.85 155 128593 77008 42415579
Incorrect route of product administration 14.85 10.85 32 128716 24273 42468314
Hepatorenal syndrome 14.80 10.85 29 128719 2825 42489762
Neoplasm progression 14.73 10.85 42 128706 28958 42463629
Neuralgia 14.67 10.85 35 128713 25612 42466975
Anxiety 14.60 10.85 261 128487 118299 42374288
Lower gastrointestinal haemorrhage 14.55 10.85 68 128680 10740 42481847
Colitis 14.43 10.85 82 128666 46490 42446097
Abnormal behaviour 14.42 10.85 37 128711 26414 42466173
Accidental overdose 14.42 10.85 41 128707 28289 42464298
Low birth weight baby 14.40 10.85 6 128742 9949 42482638
Uveitis 14.36 10.85 5 128743 9253 42483334
Loss of consciousness 14.35 10.85 373 128375 91981 42400606
Lymphocyte count decreased 14.33 10.85 40 128708 27769 42464818
Helicobacter gastritis 14.24 10.85 19 128729 1338 42491249
Injection site reaction 14.09 10.85 16 128732 15705 42476882
Pulmonary renal syndrome 13.99 10.85 9 128739 243 42492344
Hypovolaemia 13.84 10.85 70 128678 11415 42481172
Alcohol poisoning 13.79 10.85 3 128745 7571 42485016
Cerebellar haemorrhage 13.71 10.85 21 128727 1679 42490908
Cardioversion 13.68 10.85 16 128732 985 42491602
Anaemia macrocytic 13.68 10.85 32 128716 3523 42489064
Blood pressure abnormal 13.53 10.85 63 128685 9935 42482652
Gastrointestinal endoscopic therapy 13.47 10.85 4 128744 13 42492574
Periodontitis 13.38 10.85 24 128724 2187 42490400
Productive cough 13.32 10.85 96 128652 51471 42441116
Renal disorder 13.29 10.85 140 128608 28840 42463747
Periorbital haemorrhage 13.26 10.85 7 128741 129 42492458
Contusion 13.24 10.85 189 128559 41796 42450791
BK virus infection 13.19 10.85 5 128743 8779 42483808
Cystitis haemorrhagic 13.14 10.85 3 128745 7326 42485261
Hypogammaglobulinaemia 13.14 10.85 10 128738 11881 42480706
Eosinophilia 13.07 10.85 53 128695 32846 42459741
Mental status changes 13.05 10.85 189 128559 41926 42450661
Delirium 12.98 10.85 99 128649 52420 42440167
Aplastic anaemia 12.95 10.85 11 128737 12373 42480214
Gingival hypertrophy 12.91 10.85 25 128723 2414 42490173
Eosinophilic granulomatosis with polyangiitis 12.83 10.85 5 128743 8633 42483954
Acute pulmonary oedema 12.82 10.85 56 128692 8595 42483992
Atrial septal defect 12.77 10.85 4 128744 7915 42484672
Defect conduction intraventricular 12.72 10.85 11 128737 470 42492117
Central nervous system lesion 12.65 10.85 4 128744 7866 42484721
Cardiac tamponade 12.64 10.85 46 128702 6494 42486093
Osteonecrosis of jaw 12.56 10.85 24 128724 19025 42473562
Herpes simplex 12.54 10.85 3 128745 7092 42485495
Tachycardia induced cardiomyopathy 12.44 10.85 7 128741 147 42492440
Pulmonary arterial pressure increased 12.41 10.85 19 128729 1519 42491068
Sleep disorder due to a general medical condition 12.40 10.85 21 128727 17432 42475155
Dilatation atrial 12.39 10.85 23 128725 2152 42490435
Hypoperfusion 12.25 10.85 18 128730 1387 42491200
Chills 12.24 10.85 205 128543 93861 42398726
Epistaxis 12.22 10.85 276 128472 66550 42426037
Oral mucosal eruption 12.19 10.85 10 128738 397 42492190
Lacunar infarction 12.17 10.85 29 128719 3231 42489356
Delusion 12.14 10.85 16 128732 14718 42477869
Large intestinal haemorrhage 12.08 10.85 20 128728 1709 42490878
Forced expiratory volume decreased 12.04 10.85 4 128744 7626 42484961
Dilatation ventricular 12.03 10.85 25 128723 2541 42490046
Procedural hypotension 12.02 10.85 15 128733 988 42491599
Dyskinesia 12.02 10.85 38 128710 25352 42467235
Embolic stroke 11.98 10.85 38 128710 5002 42487585
Neuropathy peripheral 11.98 10.85 226 128522 101627 42390960
Gastrointestinal disorder 11.98 10.85 87 128661 46566 42446021
Incarcerated hernia 11.96 10.85 7 128741 159 42492428
Hepatic enzyme increased 11.94 10.85 85 128663 45699 42446888
Heart rate abnormal 11.92 10.85 23 128725 2216 42490371
Sepsis 11.84 10.85 487 128261 198847 42293740
Tubulointerstitial nephritis 11.81 10.85 52 128696 31496 42461091
Paranoia 11.80 10.85 15 128733 14011 42478576
Non-compaction cardiomyopathy 11.77 10.85 5 128743 55 42492532
Shunt occlusion 11.74 10.85 15 128733 1012 42491575
Muscle twitching 11.67 10.85 11 128737 11769 42480818
Dyspnoea paroxysmal nocturnal 11.67 10.85 19 128729 1601 42490986
Peripheral vascular disorder 11.66 10.85 39 128709 5278 42487309
Pneumonitis 11.60 10.85 76 128672 41642 42450945
Mydriasis 11.58 10.85 6 128742 8764 42483823
Delayed graft function 11.57 10.85 25 128723 2610 42489977
Renal injury 11.55 10.85 70 128678 12210 42480377
Schizophrenia 11.49 10.85 9 128739 10541 42482046
Mania 11.49 10.85 9 128739 10538 42482049
Needle issue 11.48 10.85 6 128742 8721 42483866
Stomatitis 11.45 10.85 97 128651 50232 42442355
Aortic aneurysm 11.45 10.85 50 128698 7673 42484914
Intercepted product preparation error 11.45 10.85 4 128744 7385 42485202
Systemic lupus erythematosus 11.42 10.85 7 128741 9317 42483270
Unresponsive to stimuli 11.40 10.85 145 128603 31258 42461329
Cardiac hypertrophy 11.37 10.85 16 128732 1185 42491402
Peripheral swelling 11.36 10.85 355 128393 89915 42402672
Lymphoma 11.35 10.85 16 128732 14305 42478282
Rhythm idioventricular 11.26 10.85 9 128739 344 42492243
Goitre 11.25 10.85 20 128728 1810 42490777
Thyroiditis 11.24 10.85 28 128720 3208 42489379
Hypertransaminasaemia 11.20 10.85 7 128741 9220 42483367
Model for end stage liver disease score abnormal 11.14 10.85 3 128745 6 42492581
Polyneuropathy 11.05 10.85 25 128723 18636 42473951
Pulmonary vascular resistance abnormality 11.03 10.85 5 128743 65 42492522
Headache 11.00 10.85 601 128147 238768 42253819
Myasthenia gravis 10.93 10.85 20 128728 16117 42476470
Device leakage 10.92 10.85 9 128739 10276 42482311
Oesophageal carcinoma 10.91 10.85 8 128740 9688 42482899
Feeling abnormal 10.88 10.85 282 128466 69504 42423083
Vitreous haemorrhage 10.87 10.85 25 128723 2722 42489865
Infective pulmonary exacerbation of cystic fibrosis 10.86 10.85 5 128743 7813 42484774

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiac failure congestive 2662.75 10.25 2194 197522 148806 110240777
Myocardial infarction 1116.38 10.25 1547 198169 190536 110199047
Hypotension 1040.24 10.25 2657 197059 521192 109868391
Cardiac failure 970.90 10.25 1430 198286 186196 110203387
Bradycardia 881.63 10.25 1238 198478 154279 110235304
BRASH syndrome 568.20 10.25 224 199492 3499 110386084
Hyperkalaemia 568.14 10.25 939 198777 134857 110254726
Acute myocardial infarction 496.96 10.25 682 199034 83095 110306488
Acute kidney injury 457.79 10.25 2311 197405 633119 109756464
Synovitis 435.26 10.25 13 199703 274079 110115504
Coronary artery disease 418.25 10.25 579 199137 71111 110318472
Completed suicide 413.48 10.25 1164 198552 241217 110148366
Syncope 372.54 10.25 1000 198716 201536 110188047
Death 369.06 10.25 2339 197377 696530 109693053
Hand deformity 359.76 10.25 7 199709 218499 110171084
Ejection fraction decreased 355.08 10.25 403 199313 40477 110349106
Atrial fibrillation 335.55 10.25 1044 198672 228598 110160985
Gastrointestinal haemorrhage 322.41 10.25 835 198881 164683 110224900
Infusion related reaction 319.81 10.25 144 199572 381018 110008565
Systemic lupus erythematosus 317.29 10.25 42 199674 254296 110135287
Cardiac failure chronic 317.17 10.25 235 199481 13576 110376007
Glossodynia 296.10 10.25 29 199687 221975 110167608
Treatment failure 295.39 10.25 69 199647 277165 110112418
Duodenal ulcer perforation 287.38 10.25 7 199709 177693 110211890
Blood creatinine increased 282.56 10.25 848 198868 182041 110207542
Joint swelling 281.44 10.25 232 199484 442613 109946970
Pericarditis 281.06 10.25 33 199683 219081 110170502
Chronic kidney disease 278.73 10.25 497 199219 75794 110313789
Off label use 274.50 10.25 1591 198125 1498594 108890989
Renal impairment 273.63 10.25 855 198861 187590 110201993
Drug intolerance 273.47 10.25 201 199515 406311 109983272
Lower respiratory tract infection 268.08 10.25 56 199660 243050 110146533
Helicobacter infection 267.41 10.25 15 199701 181862 110207721
Rheumatoid arthritis 262.76 10.25 106 199610 299507 110090076
Dyspnoea 262.70 10.25 3101 196615 1103771 109285812
Arthropathy 261.64 10.25 96 199620 287426 110102157
International normalised ratio increased 258.36 10.25 518 199198 86254 110303329
Maternal exposure during pregnancy 255.10 10.25 72 199644 254811 110134772
Hepatic enzyme increased 252.73 10.25 132 199584 320760 110068823
Folliculitis 249.06 10.25 13 199703 167640 110221943
Cardiomyopathy 245.63 10.25 303 199413 33222 110356361
Drug ineffective 245.39 10.25 1676 198040 1518864 108870719
Pulmonary oedema 242.14 10.25 551 199165 100108 110289475
Ischaemic cardiomyopathy 239.05 10.25 160 199556 7851 110381732
Renal failure 237.69 10.25 923 198793 225651 110163932
Blood pressure decreased 235.87 10.25 592 199124 114499 110275084
Muscle injury 233.84 10.25 4 199712 140803 110248780
Wound 231.34 10.25 68 199648 234369 110155214
Alopecia 230.57 10.25 192 199524 364561 110025022
Rheumatoid factor positive 217.53 10.25 4 199712 131636 110257947
Mitral valve incompetence 210.75 10.25 280 199436 33049 110356534
Fibromyalgia 208.91 10.25 30 199686 170879 110218704
Therapeutic product effect decreased 203.73 10.25 93 199623 244223 110145360
Musculoskeletal stiffness 199.19 10.25 130 199586 279692 110109891
Cerebrovascular accident 197.88 10.25 748 198968 180536 110209047
Hypoglycaemia 197.17 10.25 557 199159 115547 110274036
Ventricular tachycardia 194.60 10.25 335 199381 49674 110339909
Drug interaction 193.47 10.25 1554 198162 498629 109890954
Shock 193.03 10.25 347 199369 53241 110336342
Irritable bowel syndrome 191.28 10.25 33 199683 164182 110225401
Cardiac arrest 190.65 10.25 782 198934 195971 110193612
Hypersensitivity 187.77 10.25 274 199442 403724 109985859
Psoriatic arthropathy 187.06 10.25 61 199655 196700 110192883
Impaired healing 186.99 10.25 61 199655 196656 110192927
Dehydration 178.85 10.25 985 198731 278526 110111057
Cardiac disorder 178.41 10.25 413 199303 75867 110313716
C-reactive protein abnormal 178.12 10.25 15 199701 129680 110259903
Bursitis 173.12 10.25 17 199699 129901 110259682
Cardiomegaly 170.93 10.25 236 199480 28894 110360689
Cardiac failure acute 167.41 10.25 212 199504 23866 110365717
Discomfort 162.18 10.25 93 199623 214614 110174969
Oedema peripheral 161.84 10.25 1082 198634 327578 110062005
Lip dry 161.58 10.25 4 199712 100079 110289504
Arthralgia 161.25 10.25 792 198924 778840 109610743
Pain 156.73 10.25 1046 198670 953909 109435674
Anaemia 150.22 10.25 1579 198137 545507 109844076
Sinusitis 149.12 10.25 190 199526 296498 110093085
Sinus bradycardia 146.86 10.25 221 199495 29262 110360321
Mobility decreased 146.26 10.25 128 199588 237294 110152289
Cardiogenic shock 144.72 10.25 320 199396 57018 110332565
Drug hypersensitivity 143.66 10.25 386 199330 453704 109935879
Stomatitis 143.28 10.25 166 199550 270076 110119507
Sleep disorder due to general medical condition, insomnia type 140.29 10.25 14 199702 105629 110283954
Glomerular filtration rate decreased 139.91 10.25 214 199502 28742 110360841
Contraindicated product administered 139.90 10.25 145 199571 248122 110141461
Gastrointestinal disorder 138.97 10.25 139 199577 241813 110147770
Liver injury 138.84 10.25 49 199667 150364 110239219
Inflammation 138.54 10.25 89 199627 193149 110196434
Drug abuse 138.10 10.25 74 199642 177337 110212246
Atrioventricular block 135.82 10.25 160 199556 16717 110372866
Rash 134.21 10.25 900 198816 820064 109569519
Blood potassium increased 133.66 10.25 226 199490 33023 110356560
Haemoglobin decreased 131.64 10.25 834 198882 247893 110141690
Dizziness 131.23 10.25 1876 197840 696317 109693266
Nasopharyngitis 131.03 10.25 327 199389 394034 109995549
Intentional product use issue 130.64 10.25 153 199563 247753 110141830
Joint range of motion decreased 130.33 10.25 30 199686 121802 110267781
Migraine 130.13 10.25 74 199642 171578 110218005
Congestive cardiomyopathy 128.27 10.25 143 199573 14076 110375507
Blood cholesterol increased 127.23 10.25 89 199627 184696 110204887
Ventricular hypokinesia 126.45 10.25 127 199589 11087 110378496
Blister 124.53 10.25 136 199580 227240 110162343
Febrile neutropenia 123.87 10.25 240 199476 316527 110073056
Coronary arterial stent insertion 123.31 10.25 95 199621 5820 110383763
Wheezing 122.58 10.25 169 199547 255061 110134522
Blood urea increased 122.45 10.25 292 199424 54665 110334918
Product use in unapproved indication 121.58 10.25 408 199308 446969 109942614
Presyncope 121.31 10.25 271 199445 48616 110340967
Swelling 119.81 10.25 287 199429 350754 110038829
Ill-defined disorder 119.79 10.25 67 199649 156786 110232797
Tricuspid valve incompetence 118.98 10.25 179 199537 23694 110365889
Urticaria 118.35 10.25 249 199467 318608 110070975
Cardio-respiratory arrest 116.59 10.25 466 199250 115370 110274213
Chest pain 116.56 10.25 1114 198602 375261 110014322
Hypervolaemia 115.87 10.25 268 199448 49192 110340391
Therapeutic product effect incomplete 114.86 10.25 141 199575 223664 110165919
Mental status changes 110.95 10.25 346 199370 75776 110313807
Infection 110.70 10.25 313 199403 361887 110027696
Grip strength decreased 108.11 10.25 10 199706 80164 110309419
Sleep disorder 107.47 10.25 120 199596 198524 110191059
Blood glucose increased 107.20 10.25 499 199217 131997 110257586
Bundle branch block left 105.07 10.25 123 199593 12765 110376818
Exposure during pregnancy 103.41 10.25 90 199626 167334 110222249
Orthopnoea 103.15 10.25 113 199603 10908 110378675
Myelosuppression 101.37 10.25 23 199693 94317 110295266
Fall 101.02 10.25 1590 198126 601892 109787691
Osteoarthritis 100.25 10.25 109 199607 182514 110207069
Angina pectoris 98.14 10.25 291 199425 62004 110327579
Cardioactive drug level increased 98.10 10.25 70 199646 3812 110385771
Myocardial ischaemia 96.35 10.25 173 199543 26511 110363072
Subdural haematoma 96.02 10.25 207 199509 36247 110353336
Abdominal discomfort 95.87 10.25 376 199340 393482 109996101
Blood loss anaemia 95.36 10.25 139 199577 17886 110371697
Cerebral infarction 95.21 10.25 256 199460 51582 110338001
Suspected suicide 95.02 10.25 127 199589 15072 110374511
Type 2 diabetes mellitus 94.85 10.25 108 199608 177124 110212459
Anti-neutrophil cytoplasmic antibody positive vasculitis 93.73 10.25 78 199638 5339 110384244
Pyrexia 92.85 10.25 1107 198609 897158 109492425
Live birth 92.80 10.25 9 199707 69475 110320108
Hypertensive crisis 91.85 10.25 161 199555 24211 110365372
Wound infection 91.49 10.25 30 199686 96435 110293148
Product monitoring error 91.42 10.25 96 199620 8831 110380752
Red blood cell sedimentation rate increased 90.58 10.25 16 199700 78286 110311297
Arrhythmia 90.33 10.25 304 199412 69271 110320312
N-terminal prohormone brain natriuretic peptide increased 89.40 10.25 80 199636 6041 110383542
Night sweats 89.01 10.25 67 199649 133916 110255667
Peripheral venous disease 87.44 10.25 22 199694 84095 110305488
Angina unstable 87.34 10.25 127 199589 16305 110373278
Left ventricular dysfunction 86.99 10.25 154 199562 23339 110366244
Left ventricular dilatation 86.43 10.25 45 199671 1377 110388206
Coronary artery bypass 86.34 10.25 78 199638 5964 110383619
Glycosylated haemoglobin increased 85.11 10.25 153 199563 23466 110366117
Product use issue 84.12 10.25 285 199431 311410 110078173
Ventricular arrhythmia 83.45 10.25 97 199619 9990 110379593
Pulmonary fibrosis 83.23 10.25 40 199676 102002 110287581
Asthenia 82.38 10.25 1722 197994 687277 109702306
Blepharospasm 82.24 10.25 4 199712 54847 110334736
Dry mouth 81.20 10.25 148 199568 199800 110189783
Asthma 79.64 10.25 212 199504 250079 110139504
Unresponsive to stimuli 79.54 10.25 275 199441 63515 110326068
Haemorrhage intracranial 79.19 10.25 167 199549 28802 110360781
Left ventricular hypertrophy 78.75 10.25 108 199608 13136 110376447
Peritonitis bacterial 78.44 10.25 96 199620 10437 110379146
Fluid retention 77.62 10.25 357 199359 93950 110295633
Sciatica 77.25 10.25 35 199681 92364 110297219
Epilepsy 76.22 10.25 43 199673 100166 110289417
Nipple swelling 75.34 10.25 28 199688 369 110389214
Loss of consciousness 74.11 10.25 607 199109 195699 110193884
Diastolic dysfunction 73.53 10.25 101 199615 12303 110377280
Dialysis 73.15 10.25 129 199587 19490 110370093
Pregnancy 72.67 10.25 5 199711 51062 110338521
Bone erosion 70.77 10.25 3 199713 46368 110343215
Aortic valve incompetence 70.56 10.25 93 199623 10888 110378695
Pulmonary hypertension 69.67 10.25 239 199477 54981 110334602
Upper gastrointestinal haemorrhage 69.60 10.25 224 199492 49872 110339711
Dyspnoea exertional 69.35 10.25 371 199345 103689 110285894
Lower limb fracture 68.75 10.25 25 199691 75323 110314260
Onychomadesis 66.38 10.25 4 199712 45659 110343924
Autoimmune disorder 64.54 10.25 19 199697 65464 110324119
Renal cyst haemorrhage 63.87 10.25 30 199686 731 110388852
C-reactive protein increased 63.85 10.25 192 199524 217727 110171856
Hypercholesterolaemia 62.18 10.25 44 199672 90793 110298790
Coeliac disease 62.13 10.25 4 199712 43183 110346400
Prescribed overdose 61.85 10.25 41 199675 87540 110302043
Computerised tomogram coronary artery abnormal 61.54 10.25 19 199697 135 110389448
Cerebral haemorrhage 61.11 10.25 256 199460 64712 110324871
Electrocardiogram abnormal 60.89 10.25 116 199600 18593 110370990
Melaena 60.87 10.25 266 199450 68491 110321092
Pulmonary valve disease 59.73 10.25 23 199693 336 110389247
Carotid arteriosclerosis 59.18 10.25 47 199669 3010 110386573
Orthostatic hypotension 58.42 10.25 256 199460 65993 110323590
Arthritis 57.93 10.25 136 199580 167450 110222133
Condition aggravated 57.54 10.25 957 198759 733879 109655704
Nephrogenic anaemia 57.51 10.25 55 199661 4522 110385061
Nipple pain 57.44 10.25 32 199684 1124 110388459
Lung disorder 56.89 10.25 153 199563 179894 110209689
Nail disorder 56.75 10.25 17 199699 57918 110331665
Foot deformity 55.87 10.25 10 199706 48470 110341113
Hypovolaemia 55.85 10.25 122 199594 21552 110368031
Brain natriuretic peptide increased 55.79 10.25 84 199632 11125 110378458
Renal artery stenosis 55.02 10.25 49 199667 3677 110385906
Atrioventricular block first degree 54.94 10.25 95 199621 14130 110375453
Injection site reaction 54.84 10.25 48 199668 89022 110300561
Atrioventricular block complete 54.00 10.25 115 199601 19967 110369616
X-ray abnormal 53.47 10.25 4 199712 38113 110351470
Large intestine polyp 53.29 10.25 97 199619 15020 110374563
Ischaemic stroke 53.29 10.25 180 199536 41083 110348500
Coronary artery occlusion 52.83 10.25 99 199617 15673 110373910
Carotid artery stenosis 52.77 10.25 74 199642 9189 110380394
Osteoporosis 52.42 10.25 48 199668 87104 110302479
Hyperparathyroidism secondary 51.89 10.25 45 199671 3259 110386324
Gastrointestinal tract mucosal pigmentation 51.86 10.25 31 199685 1246 110388337
Loss of personal independence in daily activities 51.65 10.25 122 199594 149898 110239685
N-terminal prohormone brain natriuretic peptide abnormal 51.28 10.25 20 199696 303 110389280
Sinus node dysfunction 51.13 10.25 72 199644 8975 110380608
Atrial flutter 50.93 10.25 126 199590 24136 110365447
Injury 50.63 10.25 158 199558 177107 110212476
Plasma cell myeloma 50.13 10.25 236 199480 62700 110326883
Ventricular extrasystoles 50.10 10.25 120 199596 22521 110367062
Back injury 50.04 10.25 12 199704 47387 110342196
Headache 49.64 10.25 1214 198502 881163 109508420
Blood glucose decreased 49.57 10.25 141 199575 29347 110360236
Onychomycosis 48.89 10.25 6 199710 38525 110351058
Nodal rhythm 48.54 10.25 44 199672 3379 110386204
Musculoskeletal pain 48.23 10.25 169 199547 182854 110206729
Arteriosclerosis 48.21 10.25 125 199591 24642 110364941
Pleural effusion 48.18 10.25 512 199204 177197 110212386
Sinus arrest 47.75 10.25 48 199668 4194 110385389
Distributive shock 47.55 10.25 56 199660 5848 110383735
Epistaxis 47.51 10.25 400 199316 129972 110259611
Pericardial disease 47.18 10.25 24 199692 699 110388884
Torsade de pointes 47.05 10.25 117 199599 22483 110367100
Drug dependence 46.65 10.25 16 199700 50004 110339579
Azotaemia 46.57 10.25 73 199643 10012 110379571
Blood pressure inadequately controlled 46.52 10.25 63 199653 7570 110382013
Paraesthesia 46.09 10.25 301 199415 276220 110113363
Pericardial effusion 45.89 10.25 215 199501 57002 110332581
Frequent bowel movements 45.76 10.25 37 199679 71353 110318230
Ventricular internal diameter abnormal 45.34 10.25 17 199699 230 110389353
Type V hyperlipidaemia 45.18 10.25 30 199686 1452 110388131
Metabolic acidosis 44.64 10.25 321 199395 99423 110290160
Ventricular dysfunction 44.28 10.25 61 199655 7450 110382133
Renal disorder 44.24 10.25 192 199524 49287 110340296
Colitis ulcerative 43.75 10.25 45 199671 77318 110312265
Leukopenia 43.64 10.25 131 199585 148660 110240923
Labelled drug-drug interaction medication error 43.44 10.25 134 199582 29168 110360415
Implantable defibrillator insertion 43.30 10.25 27 199689 1172 110388411
Urinary tract infection 43.05 10.25 828 198888 325454 110064129
Rhabdomyolysis 42.60 10.25 367 199349 120034 110269549
Respiratory failure 42.45 10.25 584 199132 214748 110174835
Blood pressure increased 42.44 10.25 679 199037 257694 110131889
Haematuria 42.42 10.25 276 199440 82729 110306854
Erythema 42.37 10.25 330 199386 291117 110098466
Hip arthroplasty 42.37 10.25 24 199692 55789 110333794
Renal injury 42.29 10.25 100 199616 18613 110370970
Lower gastrointestinal haemorrhage 42.01 10.25 99 199617 18387 110371196
Obesity 41.61 10.25 89 199627 113262 110276321
Therapy cessation 41.60 10.25 176 199540 44681 110344902
Full blood count decreased 41.43 10.25 140 199576 31959 110357624
Road traffic accident 41.39 10.25 82 199634 107316 110282267
Sedation 41.17 10.25 39 199677 69644 110319939
Spinal epidural haematoma 41.06 10.25 30 199686 1695 110387888
Cardiac tamponade 40.43 10.25 73 199643 11234 110378349
Hypoaesthesia 40.19 10.25 368 199348 313855 110075728
Acute respiratory failure 40.15 10.25 253 199463 75007 110314576
Embolic stroke 39.98 10.25 63 199653 8680 110380903
Coronary artery stenosis 39.58 10.25 81 199635 13677 110375906
Vena cava injury 39.50 10.25 17 199699 335 110389248
Injection site pain 39.43 10.25 176 199540 177746 110211837
Dyspnoea at rest 39.36 10.25 61 199655 8285 110381298
Isosthenuria 39.22 10.25 13 199703 119 110389464
Pulmonary congestion 39.04 10.25 134 199582 30832 110358751
Mitral valve disease 39.00 10.25 39 199677 3386 110386197
Laryngitis 38.81 10.25 14 199702 42397 110347186
Conduction disorder 38.69 10.25 42 199674 4013 110385570
Physical examination abnormal 38.53 10.25 19 199697 517 110389066
Neutropenia 38.44 10.25 462 199254 374158 110015425
Sudden cardiac death 38.18 10.25 49 199667 5588 110383995
Joint stiffness 38.16 10.25 39 199677 67204 110322379
Extradural haematoma 37.70 10.25 38 199678 3331 110386252
Hyperuricaemia 37.68 10.25 82 199634 14449 110375134
Haematocrit decreased 37.63 10.25 226 199490 65891 110323692
Nodal arrhythmia 36.86 10.25 31 199685 2153 110387430
Brain natriuretic peptide abnormal 36.76 10.25 22 199694 886 110388697
Pulse absent 36.73 10.25 70 199646 11222 110378361
Cardiac discomfort 36.66 10.25 26 199690 1402 110388181
Diarrhoea 36.47 10.25 2455 197261 1137050 109252533
Depression 35.83 10.25 383 199333 316952 110072631
Varices oesophageal 35.81 10.25 54 199662 7161 110382422
Pulmonary renal syndrome 35.68 10.25 21 199695 820 110388763
Drug tolerance decreased 35.66 10.25 4 199712 27536 110362047
Hepatojugular reflux 35.58 10.25 20 199696 715 110388868
Liver function test increased 35.53 10.25 66 199650 88482 110301101
Electrocardiogram Q wave abnormal 35.35 10.25 20 199696 724 110388859
Intracardiac thrombus 35.24 10.25 41 199675 4227 110385356
Oesophageal varices haemorrhage 35.10 10.25 44 199672 4901 110384682
Diverticulum intestinal 34.90 10.25 70 199646 11649 110377934
Hepatic cytolysis 34.70 10.25 29 199687 55024 110334559
Stenosis 34.25 10.25 36 199680 3315 110386268
Hypertensive emergency 34.25 10.25 36 199680 3315 110386268
Pulseless electrical activity 34.09 10.25 86 199630 16671 110372912
No adverse event 33.83 10.25 239 199477 73600 110315983
Calcium deficiency 33.81 10.25 23 199693 1159 110388424
Dyspepsia 33.81 10.25 204 199512 190761 110198822
Ventricular fibrillation 33.69 10.25 156 199560 41157 110348426
Poisoning deliberate 33.65 10.25 4 199712 26327 110363256
Bradyarrhythmia 33.59 10.25 43 199673 4891 110384692
Blood iron decreased 33.40 10.25 93 199623 19121 110370462
Knee arthroplasty 33.21 10.25 41 199675 64907 110324676
Lethargy 32.98 10.25 285 199431 93291 110296292
Weight increased 32.95 10.25 546 199170 419098 109970485
Product prescribing error 32.83 10.25 181 199535 51150 110338433
Low cardiac output syndrome 32.78 10.25 22 199694 1084 110388499
Taste disorder 32.68 10.25 42 199674 65345 110324238
Suicidal ideation 32.64 10.25 76 199640 93861 110295722
End stage renal disease 32.58 10.25 99 199617 21374 110368209
Blood pressure abnormal 31.81 10.25 101 199615 22323 110367260
Ear infection 31.66 10.25 40 199676 62692 110326891
Vascular anastomotic haemorrhage 31.50 10.25 14 199702 299 110389284
Electrocardiogram QT prolonged 31.45 10.25 318 199398 108642 110280941
Ascites 31.33 10.25 280 199436 92528 110297055
Heart rate decreased 31.26 10.25 256 199460 82500 110307083
Rales 31.14 10.25 107 199609 24632 110364951
Hyperglycaemia 30.96 10.25 261 199455 84829 110304754
SARS-CoV-2 antibody test positive 30.70 10.25 15 199701 400 110389183
Serotonin syndrome 30.61 10.25 37 199679 59116 110330467
Drug ineffective for unapproved indication 30.54 10.25 90 199626 102748 110286835
Peripheral coldness 30.53 10.25 88 199628 18452 110371131
Phaeochromocytoma crisis 30.48 10.25 16 199700 498 110389085
Concomitant disease progression 30.34 10.25 35 199681 3575 110386008
Supraventricular tachycardia 30.19 10.25 105 199611 24317 110365266
Abdominal wall haemorrhage 29.85 10.25 18 199698 735 110388848
Hepatorenal syndrome 29.64 10.25 39 199677 4558 110385025
Jugular vein distension 29.49 10.25 24 199692 1592 110387991
Mucosal inflammation 29.39 10.25 83 199633 96058 110293525
Systolic dysfunction 29.31 10.25 38 199678 4377 110385206
Cytomegalovirus infection 29.31 10.25 33 199683 54411 110335172
Product dose omission issue 29.06 10.25 774 198942 321008 110068575
Fear 28.92 10.25 100 199616 23093 110366490
Dizziness postural 28.71 10.25 74 199642 14535 110375048
Bronchiectasis 28.71 10.25 15 199701 36478 110353105
Unevaluable event 28.49 10.25 194 199522 59033 110330550
Arterial spasm 28.49 10.25 11 199705 162 110389421
Blood potassium decreased 28.30 10.25 181 199535 53933 110335650
Aortic aneurysm 28.12 10.25 58 199658 9846 110379737
Intentional dose omission 28.08 10.25 90 199626 19990 110369593
Chronic obstructive pulmonary disease 27.96 10.25 311 199405 108847 110280736
Haematoma 27.81 10.25 191 199525 58285 110331298
Femoral artery dissection 27.65 10.25 8 199708 44 110389539
Product label confusion 27.65 10.25 4 199712 22673 110366910
Chronic left ventricular failure 27.42 10.25 21 199695 1275 110388308
Pyelitis 27.33 10.25 14 199702 414 110389169
Haemodialysis 27.17 10.25 82 199634 17637 110371946
Intentional self-injury 27.14 10.25 17 199699 37412 110352171
Ear pain 26.80 10.25 34 199682 53192 110336391
Adverse reaction 26.69 10.25 10 199706 29584 110359999
Rhabdoid tumour 26.64 10.25 7 199709 25 110389558
Sleep disorder due to a general medical condition 26.54 10.25 33 199683 52079 110337504
Primary hyperaldosteronism 26.51 10.25 12 199704 268 110389315
Peripheral vascular disorder 26.47 10.25 52 199664 8524 110381059
Oliguria 26.44 10.25 84 199632 18573 110371010
Acute pulmonary oedema 26.39 10.25 79 199637 16917 110372666
Incorrect route of product administration 26.37 10.25 47 199669 64014 110325569
Intentional overdose 26.36 10.25 360 199356 132141 110257442
Gastric ulcer haemorrhage 26.22 10.25 57 199659 10037 110379546
Haemorrhage 25.98 10.25 301 199415 106391 110283192
Cytokine release syndrome 25.97 10.25 55 199661 70251 110319332
Shunt occlusion 25.96 10.25 23 199693 1714 110387869
Urine output decreased 25.92 10.25 87 199629 19789 110369794
Abdominal pain upper 25.85 10.25 459 199257 348652 110040931
Oropharyngeal pain 25.83 10.25 141 199575 135135 110254448
Acute coronary syndrome 25.71 10.25 96 199620 23016 110366567
Electrocardiogram PR shortened 25.61 10.25 13 199703 377 110389206
Bundle branch block 25.22 10.25 23 199693 1780 110387803
Helicobacter test false negative 25.09 10.25 8 199708 64 110389519
Glomerular filtration rate abnormal 25.07 10.25 26 199690 2357 110387226
Immunodeficiency 25.05 10.25 20 199696 38818 110350765
Peritonitis 25.04 10.25 121 199595 32486 110357097
Progressive multifocal leukoencephalopathy 25.04 10.25 7 199709 24949 110364634
Subarachnoid haemorrhage 24.85 10.25 113 199603 29589 110359994
Perineal cyst 24.83 10.25 11 199705 233 110389350
Exostosis 24.58 10.25 28 199688 45928 110343655
Blood sodium decreased 24.43 10.25 135 199581 38184 110351399
Echocardiogram abnormal 24.30 10.25 27 199689 2647 110386936
Lacunar infarction 24.30 10.25 42 199674 6244 110383339
Vascular compression 24.27 10.25 16 199700 765 110388818
Electrocardiogram QRS complex abnormal 24.25 10.25 16 199700 766 110388817
Gravitational oedema 24.21 10.25 23 199693 1875 110387708
Carotid sinus syndrome 24.17 10.25 10 199706 178 110389405
Vomiting 24.15 10.25 1372 198344 909303 109480280
Aplastic anaemia 24.05 10.25 7 199709 24301 110365282
Therapy partial responder 24.01 10.25 19 199697 37042 110352541
Faeces discoloured 23.96 10.25 123 199593 33825 110355758
Myocardial necrosis 23.92 10.25 14 199702 541 110389042
Anxiety 23.89 10.25 459 199257 344619 110044964
Dilatation ventricular 23.88 10.25 33 199683 4042 110385541
Vascular graft 23.84 10.25 24 199692 2101 110387482
Muscle spasticity 23.79 10.25 18 199698 35897 110353686
Insomnia 23.65 10.25 484 199232 360106 110029477
Hepatocellular carcinoma 23.65 10.25 54 199662 9826 110379757
Pulmonary arterial pressure increased 23.52 10.25 37 199679 5090 110384493
Myxoedema coma 23.33 10.25 15 199701 687 110388896
Aortic dissection 23.18 10.25 36 199680 4897 110384686
Neck pain 23.15 10.25 129 199587 123001 110266582
Therapeutic drug monitoring analysis incorrectly performed 23.14 10.25 15 199701 697 110388886
Internal haemorrhage 22.96 10.25 54 199662 10017 110379566
Gait inability 22.94 10.25 148 199568 136228 110253355
Hormone-dependent prostate cancer 22.92 10.25 10 199706 204 110389379
Red blood cell count decreased 22.82 10.25 200 199516 65723 110323860
Aortic dilatation 22.73 10.25 24 199692 2222 110387361
Hyperlipidaemia 22.65 10.25 126 199590 35722 110353861
Peripheral arterial occlusive disease 22.52 10.25 51 199665 9229 110380354
Extrapyramidal disorder 22.51 10.25 12 199704 28855 110360728
Hepatitis 22.50 10.25 85 199631 89969 110299614
Basal ganglia haemorrhage 22.43 10.25 22 199694 1866 110387717
Mouth breathing 22.42 10.25 11 199705 296 110389287
Injection site erythema 22.18 10.25 91 199625 94085 110295498
Left atrial enlargement 22.13 10.25 21 199695 1710 110387873
Aortic arteriosclerosis 22.11 10.25 56 199660 10882 110378701
Hypoperfusion 22.10 10.25 28 199688 3153 110386430
Iron deficiency anaemia 22.03 10.25 114 199602 31445 110358138
Renal atrophy 21.86 10.25 24 199692 2322 110387261
Rheumatoid nodule 21.70 10.25 5 199711 20291 110369292
Pericardial haemorrhage 21.68 10.25 36 199680 5181 110384402
Cardiac pacemaker insertion 21.67 10.25 40 199676 6261 110383322
Cognitive disorder 21.60 10.25 83 199633 87428 110302155
Bone marrow failure 21.58 10.25 45 199671 57803 110331780
General physical health deterioration 21.23 10.25 595 199121 424700 109964883
Gastrointestinal arteriovenous malformation 21.22 10.25 16 199700 949 110388634
Bladder hypertrophy 21.16 10.25 17 199699 1107 110388476
Device expulsion 21.09 10.25 15 199701 30876 110358707
Pulse pressure increased 21.07 10.25 9 199707 174 110389409
Hydrothorax 20.98 10.25 20 199696 1638 110387945
Pallor 20.96 10.25 174 199542 56293 110333290
Coma 20.81 10.25 126 199590 117743 110271840
Gastritis erosive 20.77 10.25 58 199658 11942 110377641
Small intestinal haemorrhage 20.73 10.25 33 199683 4585 110384998
Vitreous haemorrhage 20.72 10.25 33 199683 4587 110384996
Haematochezia 20.63 10.25 308 199408 115216 110274367
Hypophagia 20.53 10.25 164 199552 52462 110337121
Renal hypoplasia 20.50 10.25 5 199711 12 110389571
Abortion spontaneous 20.47 10.25 19 199697 34263 110355320
Joint dislocation 20.36 10.25 19 199697 34171 110355412
Hospice care 20.34 10.25 59 199657 12414 110377169
Mitral valve calcification 20.28 10.25 20 199696 1708 110387875
Coagulopathy 20.27 10.25 135 199581 40776 110348807
Drug use disorder 20.25 10.25 4 199712 18070 110371513
Renal transplant 20.15 10.25 27 199689 3211 110386372
Diverticulum intestinal haemorrhagic 19.97 10.25 33 199683 4730 110384853
Neutrophil count decreased 19.96 10.25 132 199584 120809 110268774
Hypoglycaemic unconsciousness 19.94 10.25 17 199699 1203 110388380
Vessel puncture site haemorrhage 19.92 10.25 9 199707 200 110389383
Rash maculo-papular 19.90 10.25 68 199648 74154 110315429
Pruritus 19.70 10.25 854 198862 580706 109808877
Confusional state 19.66 10.25 671 199045 468009 109921574
Pneumonia 19.64 10.25 1838 197878 874876 109514707
Left atrial dilatation 19.63 10.25 28 199688 3532 110386051
Tenosynovitis 19.56 10.25 3 199713 16280 110373303
Toxicity to various agents 19.55 10.25 1058 198658 479497 109910086
Fractured coccyx 19.49 10.25 17 199699 1241 110388342
Hemiparaesthesia 19.47 10.25 11 199705 397 110389186
Prothrombin time prolonged 19.45 10.25 72 199644 17189 110372394
Heart transplant 19.40 10.25 19 199697 1609 110387974
Adverse event 19.38 10.25 116 199600 108693 110280890
Dilatation atrial 19.36 10.25 29 199687 3823 110385760
Rash erythematous 19.32 10.25 79 199637 81753 110307830
Oral herpes 19.28 10.25 22 199694 36058 110353525
Pulmonary arterial pressure abnormal 19.20 10.25 15 199701 938 110388645
Impaired work ability 19.15 10.25 12 199704 26407 110363176
Occult blood 19.08 10.25 20 199696 1836 110387747
Platelet count decreased 19.02 10.25 548 199168 229895 110159688
Memory impairment 19.01 10.25 246 199470 196698 110192885
Stent placement 18.96 10.25 41 199675 7193 110382390
Bundle branch block right 18.96 10.25 57 199659 12234 110377349
Dyspnoea paroxysmal nocturnal 18.95 10.25 23 199693 2479 110387104
Angioedema 18.93 10.25 266 199450 98234 110291349
Electrocardiogram QRS complex shortened 18.93 10.25 14 199702 806 110388777
Procedural hypotension 18.93 10.25 23 199693 2482 110387101
Blood sodium increased 18.91 10.25 35 199681 5488 110384095
Hyponatraemia 18.91 10.25 521 199195 217132 110172451
Therapeutic response decreased 18.74 10.25 100 199616 96399 110293184
Cytomegalovirus infection reactivation 18.66 10.25 5 199711 18328 110371255
International normalised ratio decreased 18.60 10.25 44 199672 8192 110381391
Diabetes mellitus 18.55 10.25 267 199449 99114 110290469
Vascular stent stenosis 18.51 10.25 18 199698 1511 110388072
Rectal prolapse 18.50 10.25 23 199693 2540 110387043
Drug resistance 18.49 10.25 47 199669 56327 110333256
Transfusion 18.47 10.25 93 199623 25379 110364204
Proctitis 18.44 10.25 4 199712 16923 110372660
Liver disorder 18.42 10.25 166 199550 142077 110247506
Gastrooesophageal reflux disease 18.42 10.25 222 199494 179754 110209829
Blood pressure systolic abnormal 18.41 10.25 11 199705 24839 110364744
Blood pressure diastolic abnormal 18.34 10.25 12 199704 25803 110363780
Cardiac aneurysm 18.29 10.25 19 199697 1726 110387857
Haemophagocytic lymphohistiocytosis 18.25 10.25 18 199698 31541 110358042
Subdural haemorrhage 18.15 10.25 38 199678 6520 110383063
Hypergastrinaemia 18.09 10.25 10 199706 346 110389237
Decreased appetite 18.06 10.25 1041 198675 474805 109914778
Diabetic foot 18.02 10.25 29 199687 4066 110385517
Malaise 17.99 10.25 1011 198705 670808 109718775
Troponin I increased 17.98 10.25 34 199682 5418 110384165
Blood 25-hydroxycholecalciferol decreased 17.90 10.25 11 199705 465 110389118
Glomerulonephritis rapidly progressive 17.82 10.25 21 199695 2194 110387389
Large intestinal haemorrhage 17.77 10.25 25 199691 3114 110386469
Ocular retrobulbar haemorrhage 17.74 10.25 8 199708 177 110389406
Delirium 17.74 10.25 157 199559 134868 110254715
Left ventricular failure 17.74 10.25 53 199663 11336 110378247
Gout 17.72 10.25 120 199596 36446 110353137
Drug reaction with eosinophilia and systemic symptoms 17.71 10.25 82 199634 82013 110307570
Infusion site reaction 17.66 10.25 5 199711 17677 110371906
Hypoxic-ischaemic encephalopathy 17.58 10.25 45 199671 8802 110380781
Food allergy 17.56 10.25 7 199709 19941 110369642
Oxygen saturation increased 17.48 10.25 13 199703 755 110388828
Mitral valve thickening 17.46 10.25 13 199703 756 110388827
Prinzmetal angina 17.42 10.25 21 199695 2248 110387335
Respiratory symptom 17.40 10.25 3 199713 14942 110374641
Chest discomfort 17.39 10.25 424 199292 173424 110216159
Cardiac output decreased 17.29 10.25 20 199696 2049 110387534
Schizophrenia 17.13 10.25 9 199707 21817 110367766
Foetal death 17.06 10.25 4 199712 16041 110373542
Abdominal pain 17.01 10.25 755 198961 512234 109877349
Injection site swelling 16.99 10.25 56 199660 61734 110327849
Blood thyroid stimulating hormone abnormal 16.97 10.25 15 199701 1114 110388469
Therapeutic response shortened 16.96 10.25 17 199699 29566 110360017
Lymphopenia 16.96 10.25 29 199687 40141 110349442
Sudden death 16.95 10.25 88 199628 24307 110365276
Neuroleptic malignant syndrome 16.89 10.25 22 199694 34037 110355546
Duodenal ulcer 16.89 10.25 75 199641 19439 110370144
Contusion 16.89 10.25 308 199408 233053 110156530
Akathisia 16.80 10.25 5 199711 17108 110372475
Metabolic encephalopathy 16.78 10.25 51 199665 11009 110378574
Essential hypertension 16.73 10.25 41 199675 7806 110381777
Metastases to nervous system 16.67 10.25 9 199707 297 110389286
Atrioventricular block second degree 16.66 10.25 42 199674 8139 110381444
Heart alternation 16.58 10.25 4 199712 9 110389574
Hypokalaemia 16.49 10.25 439 199277 182009 110207574
Thalamus haemorrhage 16.44 10.25 19 199697 1945 110387638
Agitation 16.42 10.25 128 199588 112923 110276660
Haemothorax 16.35 10.25 38 199678 6993 110382590
Panniculitis 16.34 10.25 4 199712 15578 110374005
Haematemesis 16.33 10.25 171 199545 58937 110330646
Ventricular hypertrophy 16.30 10.25 38 199678 7007 110382576
Hip fracture 16.23 10.25 114 199602 35037 110354546
Intraductal papillary mucinous neoplasm 16.19 10.25 13 199703 846 110388737
Hypoxia 16.16 10.25 326 199390 129189 110260394
Lymphadenopathy 16.11 10.25 60 199656 63775 110325808
Chronic sinusitis 16.07 10.25 13 199703 25071 110364512
Drug tolerance 16.00 10.25 5 199711 16580 110373003
Electrocardiogram ST segment 15.96 10.25 3 199713 0 110389583
Pathogen resistance 15.89 10.25 6 199710 17666 110371917
Tinnitus 15.87 10.25 56 199660 60484 110329099
Joint effusion 15.85 10.25 9 199707 20896 110368687
Arterial stenosis 15.85 10.25 17 199699 1602 110387981
Diabetes mellitus inadequate control 15.82 10.25 100 199616 29675 110359908
Oral candidiasis 15.72 10.25 36 199680 44724 110344859
Mania 15.70 10.25 9 199707 20787 110368796
Hypothermia 15.67 10.25 91 199625 26211 110363372
Affect lability 15.67 10.25 7 199709 18630 110370953
Colon cancer 15.62 10.25 65 199651 16378 110373205
Neutrophil count increased 15.58 10.25 24 199692 34628 110354955
Beta 2 microglobulin urine increased 15.56 10.25 7 199709 154 110389429
Gingival hypertrophy 15.53 10.25 28 199688 4303 110385280
Cardioactive drug level above therapeutic 15.48 10.25 8 199708 241 110389342
Macular degeneration 15.48 10.25 10 199706 21649 110367934
Shunt thrombosis 15.48 10.25 7 199709 156 110389427
Amnesia 15.47 10.25 119 199597 105289 110284294
Inability to afford medication 15.45 10.25 27 199689 4049 110385534
Haemorrhage subcutaneous 15.22 10.25 32 199684 5507 110384076
Haemorrhagic cerebral infarction 15.17 10.25 16 199700 1479 110388104
Dyslipidaemia 15.08 10.25 63 199653 15902 110373681
Hepatic encephalopathy 15.08 10.25 95 199621 28161 110361422
Malignant neoplasm progression 15.07 10.25 223 199493 174344 110215239
Helicobacter gastritis 15.05 10.25 21 199695 2595 110386988
Vascular stent thrombosis 15.05 10.25 27 199689 4134 110385449
Haemorrhoidal haemorrhage 14.89 10.25 40 199676 8053 110381530
Walking aid user 14.85 10.25 14 199702 25061 110364522
Cardiac ventricular thrombosis 14.84 10.25 23 199693 3124 110386459
Cholestasis 14.78 10.25 63 199653 64455 110325128
Anhedonia 14.67 10.25 61 199655 15367 110374216
Heart valve stenosis 14.63 10.25 7 199709 178 110389405
Platelet dysfunction 14.61 10.25 10 199706 509 110389074
Cardiac operation 14.61 10.25 33 199683 5962 110383621
Ankylosing spondylitis 14.55 10.25 5 199711 15607 110373976
Oesophageal discomfort 14.54 10.25 10 199706 513 110389070
Sedation complication 14.42 10.25 9 199707 19846 110369737
Haemorrhoids 14.37 10.25 112 199604 35560 110354023
Electrocardiogram T wave peaked 14.37 10.25 14 199702 1178 110388405
Blood pressure systolic decreased 14.26 10.25 55 199661 13386 110376197
Refractory anaemia with an excess of blasts 14.25 10.25 12 199704 835 110388748
Benign prostatic hyperplasia 14.24 10.25 68 199648 18166 110371417
Respiratory acidosis 14.20 10.25 56 199660 13770 110375813
Periodontitis 14.20 10.25 30 199686 5178 110384405
Genotype drug resistance test positive 14.18 10.25 15 199701 1391 110388192
Cerebellar haemorrhage 14.17 10.25 23 199693 3248 110386335
Hypoglycaemic coma 14.09 10.25 31 199685 5502 110384081
Brain contusion 14.05 10.25 16 199700 1612 110387971
Inappropriate antidiuretic hormone secretion 14.04 10.25 107 199609 33744 110355839
Fungal infection 14.00 10.25 46 199670 50760 110338823
Non-compaction cardiomyopathy 13.95 10.25 5 199711 59 110389524
Complications of transplanted kidney 13.91 10.25 37 199679 7405 110382178
Occult blood positive 13.90 10.25 37 199679 7408 110382175
Traumatic renal injury 13.88 10.25 3 199713 3 110389580
Idiopathic pulmonary fibrosis 13.85 10.25 29 199687 4975 110384608
Immune reconstitution inflammatory syndrome 13.79 10.25 6 199710 16220 110373363
Defect conduction intraventricular 13.78 10.25 11 199705 710 110388873
Cardiac amyloidosis 13.75 10.25 21 199695 2816 110386767
Mouth ulceration 13.67 10.25 43 199673 48095 110341488
Device inappropriate shock delivery 13.66 10.25 5 199711 63 110389520
Pemphigoid 13.63 10.25 71 199645 19636 110369947
Blood chromogranin A increased 13.62 10.25 11 199705 722 110388861
Cardiorenal syndrome 13.51 10.25 17 199699 1901 110387682
Hormone-refractory prostate cancer 13.50 10.25 12 199704 898 110388685
Product measured potency issue 13.45 10.25 7 199709 214 110389369
Gingival bleeding 13.39 10.25 71 199645 19768 110369815
Delayed graft function 13.37 10.25 26 199690 4231 110385352
Miosis 13.34 10.25 12 199704 21971 110367612
Gastric cancer 13.32 10.25 47 199669 10961 110378622
Intercepted product dispensing error 13.30 10.25 7 199709 219 110389364
Normal newborn 13.24 10.25 12 199704 21884 110367699
Extrasystoles 13.23 10.25 39 199677 8279 110381304
Cardiotoxicity 13.22 10.25 63 199653 16818 110372765
Pulmonary valve incompetence 13.18 10.25 20 199696 2666 110386917
Vaginal discharge 13.17 10.25 8 199708 17900 110371683
Failure to thrive 13.16 10.25 54 199662 13520 110376063
Fatigue 13.13 10.25 2439 197277 1213519 109176064
Tachycardia induced cardiomyopathy 13.13 10.25 7 199709 225 110389358
Peripheral swelling 13.11 10.25 596 199120 403438 109986145
Cardiac valve disease 13.11 10.25 33 199683 6388 110383195
Gastrointestinal endoscopic therapy 13.05 10.25 5 199711 72 110389511
Toe amputation 13.03 10.25 26 199690 4312 110385271
Angiopathy 13.01 10.25 40 199676 8690 110380893
QRS axis abnormal 13.01 10.25 19 199697 2449 110387134
Uveitis 13.00 10.25 12 199704 21698 110367885
Diabetic nephropathy 12.99 10.25 23 199693 3485 110386098
Haemorrhagic erosive gastritis 12.99 10.25 11 199705 771 110388812
Supraventricular extrasystoles 12.98 10.25 38 199678 8035 110381548
Shock haemorrhagic 12.95 10.25 89 199627 27158 110362425
Renal cyst 12.93 10.25 66 199650 18106 110371477
Atrial enlargement 12.91 10.25 13 199703 1138 110388445
Conjunctival scar 12.90 10.25 8 199708 344 110389239
Rhinitis 12.88 10.25 13 199703 22532 110367051
Hypertensive urgency 12.85 10.25 13 199703 1144 110388439
Feeling hot 12.83 10.25 104 199612 91002 110298581
Bronchial hyperreactivity 12.82 10.25 23 199693 3521 110386062
Transient ischaemic attack 12.79 10.25 174 199542 63808 110325775
Electrocardiogram QRS complex prolonged 12.79 10.25 52 199664 12969 110376614
Generalised tonic-clonic seizure 12.77 10.25 53 199663 54627 110334956
Cardiac dysfunction 12.72 10.25 32 199684 6191 110383392
Haemorrhagic transformation stroke 12.68 10.25 21 199695 3016 110386567
Model for end stage liver disease score abnormal 12.67 10.25 3 199713 6 110389577
Seronegative arthritis 12.67 10.25 4 199712 13173 110376410
Lupus-like syndrome 12.62 10.25 35 199681 40757 110348826
Thyroiditis 12.61 10.25 33 199683 6540 110383043
Peritoneal dialysis complication 12.56 10.25 19 199697 2527 110387056
Leukocyturia 12.55 10.25 18 199698 2282 110387301
Product taste abnormal 12.52 10.25 19 199697 2533 110387050
Arteriosclerosis coronary artery 12.51 10.25 83 199633 25035 110364548
Adverse drug reaction 12.47 10.25 126 199590 105433 110284150
Lymphocyte count decreased 12.45 10.25 57 199659 57186 110332397
Vascular pseudoaneurysm 12.45 10.25 25 199691 4165 110385418
Polyp 12.42 10.25 43 199673 9937 110379646
Cardioversion 12.41 10.25 18 199698 2305 110387278
Diabetic neuropathy 12.29 10.25 34 199682 6965 110382618
High density lipoprotein decreased 12.27 10.25 30 199686 5703 110383880
Injection site urticaria 12.23 10.25 8 199708 17207 110372376
Diverticulum 12.20 10.25 58 199658 15468 110374115
Multiple sclerosis relapse 12.17 10.25 48 199668 50192 110339391
Aortic bruit 12.14 10.25 7 199709 263 110389320
Herpes zoster 12.14 10.25 131 199585 108248 110281335
Metastases to lymph nodes 12.09 10.25 6 199710 15026 110374557
Ischaemia 12.06 10.25 40 199676 9043 110380540
Klebsiella infection 12.05 10.25 11 199705 19998 110369585
Scrotal oedema 12 10.25 15 199701 1666 110387917
Blood chloride decreased 11.98 10.25 40 199676 9075 110380508
Sinoatrial block 11.97 10.25 14 199702 1451 110388132
Left ventricular enlargement 11.97 10.25 11 199705 860 110388723
Putamen haemorrhage 11.90 10.25 9 199707 536 110389047
Eczema 11.88 10.25 79 199637 72214 110317369
Flank pain 11.87 10.25 77 199639 23053 110366530
Device breakage 11.85 10.25 5 199711 13764 110375819
Heart sounds abnormal 11.84 10.25 14 199702 1468 110388115
Atrial thrombosis 11.81 10.25 25 199691 4321 110385262
Tendonitis 11.79 10.25 18 199698 26065 110363518
Arteriovenous malformation 11.74 10.25 16 199700 1935 110387648
Appendicitis 11.61 10.25 21 199695 28443 110361140
Substance abuse 11.60 10.25 4 199712 12459 110377124
Psychotic disorder 11.51 10.25 50 199666 50887 110338696
Blood aldosterone abnormal 11.50 10.25 4 199712 43 110389540
Myocardial fibrosis 11.46 10.25 16 199700 1979 110387604
Urine albumin/creatinine ratio increased 11.45 10.25 12 199704 1101 110388482
Hypophosphataemia 11.40 10.25 27 199689 33155 110356428
Electrocardiogram T wave inversion 11.40 10.25 29 199687 5651 110383932
Fungal peritonitis 11.40 10.25 13 199703 1312 110388271
Renal tubular necrosis 11.36 10.25 94 199622 30381 110359202
Wrong technique in product usage process 11.27 10.25 221 199495 87127 110302456
Multiple injuries 11.26 10.25 22 199694 3592 110385991
Haemorrhagic stroke 11.19 10.25 52 199664 13737 110375846
Blood cyanide increased 11.18 10.25 4 199712 47 110389536
Osteonecrosis 11.16 10.25 28 199688 33713 110355870
Blood magnesium decreased 11.15 10.25 68 199648 19928 110369655
Rhinorrhoea 11.14 10.25 125 199591 102541 110287042
Hypovolaemic shock 11.11 10.25 54 199662 14529 110375054
Pernicious anaemia 11.08 10.25 10 199706 764 110388819
Carbohydrate antigen 15-3 increased 11.07 10.25 14 199702 1573 110388010
Nasal polyps 11.03 10.25 5 199711 13195 110376388
Fistula 11.02 10.25 7 199709 15292 110374291
Forced expiratory volume decreased 11.00 10.25 5 199711 13171 110376412
Ventricular dyskinesia 10.97 10.25 8 199708 451 110389132
Myocardial hypoperfusion 10.96 10.25 3 199713 13 110389570
Age-related macular degeneration 10.93 10.25 11 199705 962 110388621
Incarcerated hernia 10.92 10.25 8 199708 454 110389129
Exercise tolerance decreased 10.92 10.25 47 199669 12020 110377563
Intermittent claudication 10.89 10.25 22 199694 3679 110385904
Toxic goitre 10.88 10.25 4 199712 51 110389532
Disability 10.86 10.25 24 199692 30199 110359384
Blood creatine phosphokinase increased 10.86 10.25 189 199527 72888 110316695
Heart rate irregular 10.85 10.25 102 199614 34172 110355411
Coordination abnormal 10.85 10.25 18 199698 25210 110364373
Periorbital haemorrhage 10.84 10.25 7 199709 323 110389260
Pulmonary vascular resistance abnormality 10.84 10.25 6 199710 208 110389375
Nightmare 10.84 10.25 35 199681 38828 110350755
Low density lipoprotein increased 10.80 10.25 43 199673 10623 110378960
Epinephrine increased 10.78 10.25 3 199713 14 110389569
Anticoagulation drug level above therapeutic 10.74 10.25 25 199691 4605 110384978
Gastric antral vascular ectasia 10.73 10.25 12 199704 1185 110388398
Cerebral ventricular rupture 10.72 10.25 8 199708 467 110389116
Hepatocellular injury 10.67 10.25 51 199665 50591 110338992
Autoimmune myositis 10.67 10.25 11 199705 990 110388593
Therapy non-responder 10.64 10.25 210 199506 157097 110232486
Cerebral hyperperfusion syndrome 10.57 10.25 5 199711 124 110389459
Product quality issue 10.54 10.25 89 199627 77210 110312373
Epstein-Barr virus infection 10.48 10.25 11 199705 18727 110370856
Testicular swelling 10.47 10.25 14 199702 1662 110387921
Gastric ulcer 10.44 10.25 114 199602 39713 110349870
Aortic stenosis 10.42 10.25 49 199667 13010 110376573
Macroglossia 10.37 10.25 13 199703 1448 110388135
Palpitations 10.35 10.25 368 199348 158844 110230739
Oropharyngitis fungal 10.34 10.25 6 199710 228 110389355
Phaeochromocytoma 10.33 10.25 10 199706 835 110388748
Hyperhidrosis 10.30 10.25 425 199291 186873 110202710
International normalised ratio abnormal 10.30 10.25 30 199686 6327 110383256
Blood pressure fluctuation 10.27 10.25 86 199630 74738 110314845
Traumatic intracranial haemorrhage 10.27 10.25 13 199703 1463 110388120

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AG02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Alpha and beta blocking agents
ATC C07FX06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA MoA N0000000099 Adrenergic alpha-Antagonists
FDA MoA N0000009923 Adrenergic beta1-Antagonists
FDA MoA N0000009924 Adrenergic beta2-Antagonists
FDA EPC N0000175553 alpha-Adrenergic Blocker
FDA EPC N0000175556 beta-Adrenergic Blocker
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35530 β-adrenergic antagonist
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:37890 α-adrenergic antagonist
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:76916 hyperglycemic agent
CHEBI has role CHEBI:145947 antiatherosclerotic agent
CHEBI has role CHEBI:231911 renoprotective agent
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000317 Adrenergic alpha-Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000959 Antihypertensive Agents
MeSH PA D000975 Antioxidants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D020011 Protective Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D058668 Adrenergic alpha-1 Receptor Antagonists

Related Drugs by ATC class:

C07AG Alpha and beta blocking agents 1 drug
labetalol
C07FX Beta blocking agents, other combinations 6 drugs
acetylsalicylic acidbisoprololivabradinemetoprololpropranololsotalol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Left ventricular cardiac dysfunction indication 429589006
Atrial fibrillation off-label use 49436004 DOID:0060224
Diastolic heart failure off-label use 418304008 DOID:9775
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Bronchospasm contraindication 4386001
Complete atrioventricular block contraindication 27885002
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Hepatic failure contraindication 59927004
Chronic bronchitis contraindication 63480004 DOID:6132
Diabetes mellitus contraindication 73211009 DOID:9351
Prinzmetal angina contraindication 87343002
Pulmonary emphysema contraindication 87433001
Cardiogenic shock contraindication 89138009
Second degree atrioventricular block contraindication 195042002
Asthma contraindication 195967001 DOID:2841
Pregnancy, function contraindication 289908002
Peripheral vascular disease contraindication 400047006
Intraoperative floppy iris syndrome contraindication 418801006
Acutely Decompensated HF Requiring Parenteral Inotropic Therapy contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.13 acidic
pKa2 7.88 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.90 IUPHAR CHEMBL
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9.50 IUPHAR CHEMBL
D(1A) dopamine receptor GPCR Ki 6.13 DRUG MATRIX
D(2) dopamine receptor GPCR Ki 7.31 DRUG MATRIX
Alpha-2A adrenergic receptor GPCR Ki 7.40 DRUG MATRIX
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 6.46 CHEMBL
Sodium-dependent serotonin transporter Transporter Ki 6.93 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 6.27 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 8.48 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.93 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 7.82 DRUG MATRIX
5-hydroxytryptamine receptor 2C GPCR Ki 7.22 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 6.15 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR ANTAGONIST Ki 8.66 WOMBAT-PK
Alpha-2B adrenergic receptor GPCR Ki 7.37 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.71 DRUG MATRIX
Beta-3 adrenergic receptor GPCR ANTAGONIST Ki 9.40 IUPHAR
Alpha-2C adrenergic receptor GPCR Ki 7.89 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 6.17 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR ANTAGONIST Ki 9.05 DRUG MATRIX
Potassium channel subfamily K member 2 Ion channel IC50 5.80 CHEMBL
Solute carrier family 22 member 1 Transporter IC50 5.47 CHEMBL
Potassium channel subfamily K member 10 Ion channel IC50 5.12 CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.12 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 4.03 CHEMBL
Cytochrome P450 1B1 Enzyme IC50 5.96 CHEMBL
Toll-like receptor 4 Membrane receptor IC50 4.49 CHEMBL
Ryanodine receptor 2 Ion channel INHIBITOR IC50 4.80 IUPHAR
Amyloid beta A4 protein Membrane other IC50 4.52 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 8.71 DRUG MATRIX
5-hydroxytryptamine receptor 1B GPCR Ki 6.23 DRUG MATRIX
Alpha-1A adrenergic receptor GPCR IC50 8.11 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 8.50 CHEMBL
Beta-1 adrenergic receptor GPCR Ki 9.09 CHEMBL
5-hydroxytryptamine receptor 4 GPCR Ki 6.74 DRUG MATRIX

External reference:

IDSource
4021041 VUID
N0000148505 NUI
D00255 KEGG_DRUG
610309-89-2 SECONDARY_CAS_RN
20352 RXNORM
C0054836 UMLSCUI
CHEBI:3441 CHEBI
CVD PDB_CHEM_ID
CHEMBL723 ChEMBL_ID
CHEMBL1201167 ChEMBL_ID
D000077261 MESH_DESCRIPTOR_UI
DB01136 DRUGBANK_ID
2585 PUBCHEM_CID
551 IUPHAR_LIGAND_ID
5333 INN_ID
0K47UL67F2 UNII
119032 MMSL
22339 MMSL
265288 MMSL
4363 MMSL
d03847 MMSL
108551001 SNOMEDCT_US
386870007 SNOMEDCT_US
426471008 SNOMEDCT_US
374779-41-6 SECONDARY_CAS_RN
4021041 VANDF
4026028 VANDF
004167 NDDF
011844 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0051 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-0135 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7295 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0093-7296 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1248 CAPSULE, EXTENDED RELEASE 10 mg ORAL ANDA 26 sections
Carvedilol Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1249 CAPSULE, EXTENDED RELEASE 20 mg ORAL ANDA 26 sections
Carvedilol Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1250 CAPSULE, EXTENDED RELEASE 40 mg ORAL ANDA 26 sections
Carvedilol Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0115-1251 CAPSULE, EXTENDED RELEASE 80 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8387 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8388 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8389 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0615-8390 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5221 TABLET, FILM COATED 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5222 TABLET, FILM COATED 6.25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5223 TABLET, FILM COATED 12.50 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0781-5224 TABLET, FILM COATED 25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6300 TABLET, FILM COATED 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6301 TABLET, FILM COATED 6.25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6302 TABLET, FILM COATED 12.50 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-6303 TABLET, FILM COATED 25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7305 TABLET, FILM COATED 3.13 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7306 TABLET, FILM COATED 6.25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7307 TABLET, FILM COATED 12.50 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 0904-7308 TABLET, FILM COATED 25 mg ORAL ANDA 26 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10135-633 TABLET 3.13 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10135-634 TABLET 6.25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10135-635 TABLET 12.50 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10135-637 TABLET 25 mg ORAL ANDA 25 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10544-184 TABLET, FILM COATED 3.13 mg ORAL ANDA 28 sections
Carvedilol HUMAN PRESCRIPTION DRUG LABEL 1 10544-187 TABLET, FILM COATED 6.25 mg ORAL ANDA 28 sections