metoprolol Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1786 51384-51-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metoprolol fumarate
  • metoprolol
  • metoprolol succinate
  • beatrolol
  • metoprolol tartrate
A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.
  • Molecular weight: 267.37
  • Formula: C15H25NO3
  • CLOGP: 1.49
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 50.72
  • ALOGS: -2.82
  • ROTB: 9

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

Approvals:

DateAgencyCompanyOrphan
Aug. 7, 1978 FDA US PHARMS HOLDINGS I

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 5520.70 29.50 1420 7173 29694 3347572
Bradycardia 3478.26 29.50 872 7721 15797 3361469
Hypotension 2583.57 29.50 883 7710 48631 3328635
Toxicity to various agents 1646.46 29.50 627 7966 46427 3330839
Syncope 1182.61 29.50 420 8173 25213 3352053
Cardiac arrest 990.15 29.50 375 8218 26944 3350322
Dizziness 932.26 29.50 488 8105 76024 3301242
Intentional overdose 873.01 29.50 294 8299 14931 3362335
Overdose 701.35 29.50 312 8281 33666 3343600
Drug interaction 608.97 29.50 313 8280 46499 3330767
Drug hypersensitivity 608.38 29.50 287 8306 35393 3341873
Sinus bradycardia 557.86 29.50 148 8445 3231 3374035
Suicide attempt 531.05 29.50 206 8387 15641 3361625
Cardiogenic shock 501.26 29.50 140 8453 3726 3373540
Atrial fibrillation 493.59 29.50 220 8373 23721 3353545
Blood pressure increased 463.69 29.50 206 8387 22024 3355242
Hypertension 456.02 29.50 242 8351 38224 3339042
Dyspnoea 447.82 29.50 343 8250 102591 3274675
Poisoning 441.21 29.50 135 8458 4977 3372289
Heart rate decreased 432.73 29.50 134 8459 5144 3372122
Acute kidney injury 390.50 29.50 239 8354 49444 3327822
Fatigue 375.77 29.50 315 8278 106925 3270341
Respiratory arrest 374.18 29.50 146 8447 11222 3366044
Cardio-respiratory arrest 370.31 29.50 158 8435 15282 3361984
Hyperkalaemia 364.49 29.50 143 8450 11151 3366115
Fall 362.92 29.50 243 8350 58640 3318626
Orthostatic hypotension 342.87 29.50 111 8482 4925 3372341
Death 338.72 29.50 347 8246 151977 3225289
Foetal exposure during pregnancy 326.76 29.50 145 8448 15406 3361860
Medication error 319.77 29.50 132 8461 11739 3365527
Asthenia 311.55 29.50 231 8362 65434 3311832
Premature baby 299.49 29.50 110 8483 7143 3370123
Hypoglycaemia 279.99 29.50 127 8466 14191 3363075
Palpitations 265.65 29.50 134 8459 18949 3358317
Intentional product misuse 265.33 29.50 118 8475 12583 3364683
Drug ineffective 263.72 29.50 268 8325 115822 3261444
Blood pressure decreased 258.79 29.50 119 8474 13717 3363549
Ventricular tachycardia 253.47 29.50 92 8501 5770 3371496
Somnolence 252.67 29.50 155 8438 32049 3345217
Atrioventricular block 251.48 29.50 72 8521 2092 3375174
Exposure via ingestion 239.56 29.50 64 8529 1429 3375837
Presyncope 237.03 29.50 85 8508 5146 3372120
Chest pain 228.05 29.50 158 8435 40117 3337149
Exposure during pregnancy 227.28 29.50 137 8456 27426 3349840
Cardiac failure 224.99 29.50 122 8471 19983 3357283
Drug abuse 224.15 29.50 118 8475 18212 3359054
Atrioventricular block complete 221.51 29.50 67 8526 2365 3374901
Nausea 218.70 29.50 256 8337 129389 3247877
Condition aggravated 217.63 29.50 152 8441 39081 3338185
Maternal exposure during pregnancy 216.31 29.50 96 8497 10175 3367091
Metabolic acidosis 214.08 29.50 91 8502 8687 3368579
Confusional state 203.25 29.50 144 8449 37854 3339412
Pulmonary oedema 202.70 29.50 96 8497 11815 3365451
Tachycardia 202.59 29.50 120 8473 23251 3354015
Arrhythmia 193.00 29.50 89 8504 10308 3366958
Renal failure 185.81 29.50 129 8464 32811 3344455
Heart rate increased 182.00 29.50 95 8498 14391 3362875
Actinic keratosis 181.60 29.50 45 8548 736 3376530
Hyperhidrosis 180.84 29.50 112 8481 23498 3353768
Unresponsive to stimuli 178.76 29.50 78 8515 7930 3369336
Blood pressure inadequately controlled 177.38 29.50 50 8543 1370 3375896
Malaise 172.61 29.50 164 8429 65013 3312253
Shock 169.39 29.50 72 8521 6865 3370401
Blood pressure systolic increased 167.87 29.50 58 8535 3141 3374125
Loss of consciousness 167.60 29.50 114 8479 28033 3349233
Nodal rhythm 165.46 29.50 40 8553 587 3376679
Caesarean section 162.49 29.50 62 8531 4464 3372802
Low birth weight baby 160.65 29.50 48 8545 1622 3375644
Ventricular extrasystoles 159.19 29.50 57 8536 3430 3373836
Atrioventricular block first degree 157.50 29.50 47 8546 1581 3375685
Ejection fraction decreased 156.79 29.50 59 8534 4088 3373178
Lactic acidosis 154.32 29.50 69 8524 7431 3369835
Blood creatinine increased 150.77 29.50 97 8496 21721 3355545
Ventricular fibrillation 150.69 29.50 58 8535 4275 3372991
Anxiety 145.29 29.50 120 8473 39509 3337757
Mental status changes 140.28 29.50 71 8522 10076 3367190
Atrioventricular block second degree 140.24 29.50 40 8553 1144 3376122
Torsade de pointes 140.10 29.50 50 8543 2979 3374287
Blood glucose increased 139.39 29.50 88 8505 19067 3358199
Atrial septal defect 138.86 29.50 49 8544 2824 3374442
Dehydration 138.39 29.50 109 8484 33540 3343726
Product substitution issue 128.44 29.50 61 8532 7539 3369727
Lethargy 126.67 29.50 74 8519 13941 3363325
Small for dates baby 126.27 29.50 40 8553 1647 3375619
Heart rate irregular 124.59 29.50 47 8546 3277 3373989
Product quality issue 123.89 29.50 93 8500 26642 3350624
Dysarthria 120.42 29.50 63 8530 9571 3367695
Vomiting 118.61 29.50 157 8436 89374 3287892
Myocardial infarction 118.45 29.50 112 8481 44021 3333245
Circulatory collapse 116.01 29.50 53 8540 5996 3371270
Renal impairment 113.47 29.50 76 8517 18185 3359081
Angina pectoris 112.51 29.50 56 8537 7665 3369601
Hypospadias 106.74 29.50 29 8564 690 3376576
Pain in extremity 106.35 29.50 111 8482 49101 3328165
Atrial flutter 106.08 29.50 39 8554 2529 3374737
Sinus node dysfunction 105.34 29.50 32 8561 1144 3376122
Chest discomfort 105.14 29.50 71 8522 17214 3360052
Haemodynamic instability 104.52 29.50 36 8557 1929 3375337
Electrocardiogram QT prolonged 102.85 29.50 59 8534 10736 3366530
Coma 102.27 29.50 62 8531 12490 3364776
Insomnia 101.86 29.50 94 8499 35804 3341462
Oedema peripheral 99.48 29.50 91 8502 34270 3342996
Hyponatraemia 98.94 29.50 70 8523 18289 3358977
Pulseless electrical activity 98.68 29.50 33 8560 1615 3375651
Patent ductus arteriosus 96.48 29.50 31 8562 1336 3375930
Bowen's disease 96.19 29.50 23 8570 321 3376945
Headache 96.07 29.50 144 8449 91836 3285430
Maternal drugs affecting foetus 94.88 29.50 40 8553 3731 3373535
Sinus arrest 94.13 29.50 25 8568 544 3376722
Acute myocardial infarction 93.39 29.50 58 8535 12193 3365073
Hyperlipidaemia 93.32 29.50 42 8551 4586 3372680
Weight decreased 93.00 29.50 94 8499 40017 3337249
Abdominal pain 92.30 29.50 100 8493 46125 3331141
Feeling abnormal 91.81 29.50 79 8514 27446 3349820
Drug level increased 90.86 29.50 41 8552 4504 3372762
Cough 89.85 29.50 92 8501 39766 3337500
Hypokalaemia 89.47 29.50 59 8534 13746 3363520
Electrocardiogram QRS complex prolonged 88.79 29.50 29 8564 1317 3375949
Depression 88.20 29.50 91 8502 39679 3337587
Nodal arrhythmia 86.57 29.50 22 8571 400 3376866
Cardiomegaly 86.30 29.50 39 8554 4299 3372967
Acidosis 86.15 29.50 34 8559 2676 3374590
Dyspnoea exertional 85.95 29.50 45 8548 6841 3370425
Pulmonary congestion 85.67 29.50 35 8558 3015 3374251
Diarrhoea 85.15 29.50 146 8447 104202 3273064
Precancerous skin lesion 84.46 29.50 20 8573 267 3376999
Macrophages increased 83.93 29.50 14 8579 20 3377246
Basal cell carcinoma 83.70 29.50 37 8556 3872 3373394
Supraventricular tachycardia 83.46 29.50 35 8558 3221 3374045
Blood pressure diastolic decreased 80.94 29.50 28 8565 1519 3375747
Hypoperfusion 79.31 29.50 20 8573 352 3376914
Bradyarrhythmia 79.22 29.50 22 8571 569 3376697
Substance-induced psychotic disorder 77.38 29.50 20 8573 390 3376876
Depressed level of consciousness 76.72 29.50 50 8543 11415 3365851
Sleep disorder 75.35 29.50 44 8549 8269 3368997
Poisoning deliberate 75.30 29.50 24 8569 1007 3376259
Hypoglycaemia neonatal 75.26 29.50 21 8572 553 3376713
Disorientation 75.00 29.50 47 8546 10032 3367234
Ventricular hypokinesia 73.67 29.50 24 8569 1081 3376185
Gait disturbance 73.03 29.50 70 8523 27922 3349344
Acute respiratory failure 72.14 29.50 35 8558 4527 3372739
Pain 71.74 29.50 110 8483 71447 3305819
Premature delivery 71.22 29.50 29 8564 2476 3374790
Electrocardiogram abnormal 70.40 29.50 28 8565 2249 3375017
Hypoxia 69.12 29.50 44 8549 9647 3367619
Agitation 68.62 29.50 58 8535 19648 3357618
Foetal growth restriction 68.48 29.50 26 8567 1843 3375423
Sinus tachycardia 66.94 29.50 34 8559 4851 3372415
Angioedema 66.40 29.50 51 8542 15084 3362182
Drug intolerance 65.89 29.50 46 8547 11752 3365514
Drug-induced liver injury 65.48 29.50 34 8559 5079 3372187
Left ventricular hypertrophy 65.48 29.50 23 8570 1306 3375960
Drug dispensing error 64.88 29.50 31 8562 3877 3373389
Coronary artery stenosis 64.43 29.50 26 8567 2168 3375098
Blood pressure fluctuation 64.30 29.50 26 8567 2180 3375086
Blood pressure systolic decreased 64.23 29.50 22 8571 1158 3376108
Anuria 63.94 29.50 28 8565 2863 3374403
Pulse absent 63.68 29.50 24 8569 1667 3375599
Back pain 63.51 29.50 75 8518 37930 3339336
Incorrect dose administered 63.49 29.50 48 8545 13866 3363400
Decreased appetite 63.01 29.50 78 8515 41412 3335854
Blood pressure abnormal 62.95 29.50 25 8568 2000 3375266
Brain oedema 62.62 29.50 30 8563 3774 3373492
Premature labour 62.50 29.50 25 8568 2038 3375228
Blood ethanol increased 61.27 29.50 13 8580 101 3377165
Apnoea 61.14 29.50 26 8567 2476 3374790
Bezoar 59.91 29.50 15 8578 256 3377010
Arthralgia 58.78 29.50 92 8501 60769 3316497
General physical health deterioration 58.50 29.50 54 8539 20535 3356731
Extrasystoles 58.25 29.50 22 8571 1537 3375729
Cardiomyopathy 58.08 29.50 31 8562 4895 3372371
Erectile dysfunction 57.35 29.50 29 8564 4098 3373168
Vertigo 57.25 29.50 42 8551 11590 3365676
Alcohol poisoning 56.52 29.50 18 8575 753 3376513
Dry mouth 56.49 29.50 39 8554 9783 3367483
Haemoglobin decreased 56.01 29.50 63 8530 30231 3347035
Oesophageal obstruction 55.80 29.50 13 8580 161 3377105
Brain injury 54.54 29.50 21 8572 1546 3375720
Therapeutic response unexpected 53.94 29.50 30 8563 5138 3372128
Electrocardiogram ST segment elevation 53.88 29.50 20 8573 1331 3375935
Carcinoma in situ of skin 53.76 29.50 11 8582 70 3377196
Seizure 53.54 29.50 71 8522 40329 3336937
Onychomycosis 53.41 29.50 17 8576 710 3376556
Coronary artery disease 53.33 29.50 45 8548 15198 3362068
Pallor 53.08 29.50 31 8562 5824 3371442
International normalised ratio increased 52.90 29.50 44 8549 14571 3362695
Peripheral coldness 52.83 29.50 23 8570 2319 3374947
Musculoskeletal stiffness 52.58 29.50 43 8550 13907 3363359
Delirium 52.50 29.50 37 8556 9591 3367675
Optic ischaemic neuropathy 52.04 29.50 17 8576 772 3376494
Phaeochromocytoma crisis 51.97 29.50 10 8583 44 3377222
Supraventricular extrasystoles 51.69 29.50 19 8574 1230 3376036
Myalgia 51.43 29.50 62 8531 32013 3345253
Bundle branch block left 51.31 29.50 20 8573 1522 3375744
Implant site extravasation 51.09 29.50 14 8579 344 3376922
Acute coronary syndrome 50.99 29.50 25 8568 3307 3373959
Wheezing 50.69 29.50 34 8559 8137 3369129
Left ventricular dysfunction 50.68 29.50 21 8572 1874 3375392
Systolic anterior motion of mitral valve 50.57 29.50 8 8585 6 3377260
Vasoplegia syndrome 50.41 29.50 12 8581 164 3377102
Arteriospasm coronary 50.22 29.50 18 8575 1084 3376182
Hepatic steatosis 49.82 29.50 28 8565 4892 3372374
Pruritus 49.72 29.50 74 8519 46759 3330507
Vomiting projectile 49.45 29.50 14 8579 389 3376877
Weight increased 48.38 29.50 55 8538 26685 3350581
Electrocardiogram T wave inversion 48.36 29.50 17 8576 967 3376299
Muscle spasms 48.11 29.50 55 8538 26848 3350418
Pre-eclampsia 48.10 29.50 18 8575 1225 3376041
Blood sodium decreased 47.77 29.50 27 8566 4769 3372497
Mitral valve incompetence 47.06 29.50 25 8568 3909 3373357
Diabetes mellitus 46.99 29.50 38 8555 12095 3365171
Ventricular arrhythmia 46.83 29.50 17 8576 1062 3376204
Implant site infection 46.24 29.50 15 8578 666 3376600
Dizziness postural 46.21 29.50 18 8575 1367 3375899
Muscular weakness 45.85 29.50 47 8546 20294 3356972
Blood potassium decreased 45.78 29.50 29 8564 6301 3370965
Product use issue 45.50 29.50 42 8551 15959 3361307
Hypertensive emergency 45.22 29.50 12 8581 260 3377006
Rash 44.90 29.50 89 8504 70732 3306534
Wound dehiscence 44.74 29.50 17 8576 1207 3376059
Hepatic ischaemia 44.52 29.50 10 8583 104 3377162
Body temperature decreased 44.41 29.50 19 8574 1835 3375431
Purpura senile 43.97 29.50 8 8585 24 3377242
Laceration 43.95 29.50 24 8569 3964 3373302
Scratch 43.61 29.50 16 8577 1030 3376236
Hypertensive crisis 43.39 29.50 22 8571 3125 3374141
Peripheral swelling 43.29 29.50 41 8552 16091 3361175
Hypersensitivity 43.21 29.50 53 8540 27847 3349419
Ischaemic hepatitis 43.15 29.50 13 8580 451 3376815
Reaction to excipient 43.10 29.50 13 8580 453 3376813
Accidental overdose 42.67 29.50 29 8564 7089 3370177
Acute lung injury 42.53 29.50 11 8582 215 3377051
Pacemaker generated rhythm 42.38 29.50 7 8586 9 3377257
Hypotonia 42.32 29.50 21 8572 2850 3374416
Coagulopathy 42.23 29.50 25 8568 4814 3372452
Balance disorder 42.03 29.50 36 8557 12403 3364863
Cardioactive drug level increased 41.92 29.50 13 8580 498 3376768
Visual impairment 41.92 29.50 38 8555 14108 3363158
Sudden death 41.45 29.50 24 8569 4436 3372830
Normal newborn 41.38 29.50 17 8576 1484 3375782
Hallucination, visual 41.37 29.50 24 8569 4452 3372814
Bundle branch block right 41.18 29.50 18 8575 1832 3375434
Conjunctival hyperaemia 41.05 29.50 15 8578 955 3376311
Myocardial ischaemia 40.86 29.50 25 8568 5109 3372157
Intentional self-injury 40.63 29.50 25 8568 5160 3372106
Memory impairment 40.15 29.50 38 8555 14900 3362366
Chronic obstructive pulmonary disease 39.53 29.50 33 8560 10976 3366290
Abdominal distension 39.31 29.50 36 8557 13540 3363726
Angina unstable 39.19 29.50 21 8572 3341 3373925
Naevus flammeus 39.08 29.50 8 8585 51 3377215
Cardiotoxicity 38.94 29.50 17 8576 1725 3375541
Treatment noncompliance 38.90 29.50 30 8563 8915 3368351
Blood urea increased 38.79 29.50 28 8565 7532 3369734
Dysphagia 38.25 29.50 42 8551 19609 3357657
Chronic kidney disease 38.21 29.50 26 8567 6366 3370900
Congenital cystic lung 37.83 29.50 8 8585 61 3377205
Hypothyroidism 37.72 29.50 25 8568 5864 3371402
Cardiac failure congestive 37.33 29.50 51 8542 29771 3347495
Accidental exposure to product 37.28 29.50 23 8570 4769 3372497
White blood cell count increased 37.26 29.50 34 8559 12726 3364540
Blood ketone body increased 37.15 29.50 9 8584 133 3377133
Cardiac disorder 37.06 29.50 35 8558 13684 3363582
Bronchospasm 36.99 29.50 22 8571 4272 3372994
Restlessness 36.91 29.50 27 8566 7411 3369855
Hepatic failure 36.33 29.50 31 8562 10621 3366645
Hydrops foetalis 36.31 29.50 9 8584 147 3377119
Pleural effusion 36.31 29.50 40 8553 18739 3358527
Skin cancer 36.27 29.50 17 8576 2035 3375231
Bradycardia neonatal 35.91 29.50 11 8582 404 3376862
Urine output decreased 35.72 29.50 18 8575 2523 3374743
Adverse drug reaction 35.71 29.50 29 8564 9282 3367984
Tricuspid valve sclerosis 35.04 29.50 6 8587 11 3377255
Heart rate abnormal 34.99 29.50 12 8581 634 3376632
Vision blurred 34.93 29.50 40 8553 19549 3357717
Abdominal pain upper 34.86 29.50 45 8548 24871 3352395
Unevaluable event 34.63 29.50 33 8560 13043 3364223
Stress 34.52 29.50 26 8567 7460 3369806
Abdominal discomfort 34.41 29.50 39 8554 18845 3358421
Morning glory syndrome 34.40 29.50 5 8588 0 3377266
Asthma 34.19 29.50 32 8561 12370 3364896
Tarsal tunnel syndrome 34.01 29.50 7 8586 46 3377220
Therapy non-responder 33.93 29.50 30 8563 10779 3366487
Type 2 diabetes mellitus 33.89 29.50 19 8574 3302 3373964
Congenital hydronephrosis 33.74 29.50 9 8584 199 3377067
Epistaxis 33.67 29.50 34 8559 14417 3362849
Osteoarthritis 33.66 29.50 26 8567 7744 3369522
Productive cough 33.61 29.50 24 8569 6347 3370919
Respiratory rate increased 33.52 29.50 17 8576 2416 3374850
Neutrophil count increased 33.36 29.50 20 8573 3940 3373326
Mydriasis 33.28 29.50 18 8575 2916 3374350
Hypoaesthesia 33.27 29.50 44 8549 24895 3352371
Electrocardiogram QRS complex shortened 33.23 29.50 8 8585 115 3377151
Pupillary reflex impaired 33.20 29.50 12 8581 740 3376526
Off label use 33.18 29.50 67 8526 53910 3323356
Loss of personal independence in daily activities 32.85 29.50 22 8571 5248 3372018
Respiratory failure 32.70 29.50 42 8551 23099 3354167
Mental disorder 32.61 29.50 23 8570 5964 3371302
Haemorrhage intracranial 32.59 29.50 22 8571 5317 3371949
Scar 32.27 29.50 17 8576 2612 3374654
Cerebrovascular accident 32.16 29.50 52 8541 35236 3342030
Electrocardiogram T wave abnormal 32.15 29.50 11 8582 577 3376689
Speech disorder 32.01 29.50 27 8566 9105 3368161
Cardiac murmur 31.83 29.50 17 8576 2686 3374580
Constipation 31.69 29.50 48 8545 30764 3346502
Nightmare 31.28 29.50 22 8571 5680 3371586
Erythema 31.23 29.50 46 8547 28764 3348502
Brugada syndrome 31.19 29.50 9 8584 268 3376998
Myoclonus 31.13 29.50 19 8574 3864 3373402
Urinary tract infection 31.09 29.50 48 8545 31280 3345986
Blood cholesterol increased 31.08 29.50 24 8569 7145 3370121
Alopecia 30.90 29.50 37 8556 18949 3358317
Pulmonary hypertension 30.88 29.50 23 8570 6487 3370779
Dilatation atrial 30.82 29.50 11 8582 654 3376612
Joint swelling 30.69 29.50 35 8558 17022 3360244
Purulent discharge 30.63 29.50 13 8580 1231 3376035
Acute respiratory distress syndrome 30.62 29.50 22 8571 5872 3371394
Foetal distress syndrome 30.39 29.50 11 8582 681 3376585
Environmental exposure 30.24 29.50 7 8586 84 3377182
Multiple organ dysfunction syndrome 30.14 29.50 32 8561 14378 3362888
Orthopnoea 30.13 29.50 12 8581 966 3376300
Congenital musculoskeletal anomaly 29.99 29.50 8 8585 177 3377089
Serotonin syndrome 29.93 29.50 21 8572 5402 3371864
Respiratory distress 29.81 29.50 25 8568 8363 3368903
Rales 29.74 29.50 14 8579 1692 3375574
Oligohydramnios 29.71 29.50 12 8581 1002 3376264
Oedema 29.65 29.50 32 8561 14648 3362618
Cold sweat 29.64 29.50 17 8576 3086 3374180

Pharmacologic Action:

SourceCodeDescription
ATC C07AB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07BB52 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
ATC C07CB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, selective, and other diuretics
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FX03 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
ATC C07FX05 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents, other combinations
FDA EPC N0000175556 beta-Adrenergic Blocker
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D000889 Anti-Arrhythmia Agents
CHEBI has role CHEBI:35530 beta-adrenergic antagonist
CHEBI has role CHEBI:35674 antihypertensive agent
MeSH PA D000959 Antihypertensive Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Myocardial infarction indication 22298006 DOID:5844
Hypertensive disorder indication 38341003 DOID:10763
Chronic heart failure indication 48447003
Angina pectoris indication 194828000
Acute coronary syndrome indication 394659003
Myocardial Reinfarction Prevention indication
Supraventricular tachycardia off-label use 6456007
Ventricular tachycardia off-label use 25569003
Atrial fibrillation off-label use 49436004 DOID:0060224
Multifocal atrial tachycardia off-label use 49982000
Paroxysmal supraventricular tachycardia off-label use 67198005
Thyrotoxicosis off-label use 90739004 DOID:7997
Paroxysmal atrial tachycardia off-label use 195069001
Ectopic atrial tachycardia off-label use 233892002
Mitral valve prolapse off-label use 409712001 DOID:988
Diastolic heart failure off-label use 418304008 DOID:9775
Migraine Prevention off-label use
Prevention of Congenital Long QT Syndrome associated Ventricular Arrhythmia off-label use
Prevention of Post Cardio-Thoracic Surgery Atrial Fibrillation off-label use
Pheochromocytoma Adjunct Therapy off-label use
Anuria contraindication 2472002 DOID:2983
Bronchospasm contraindication 4386001
Psoriasis contraindication 9014002 DOID:8893
Hypercholesterolemia contraindication 13644009
Secondary angle-closure glaucoma contraindication 21571006
Complete atrioventricular block contraindication 27885002
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007 DOID:2848
Hyperuricemia contraindication 35885006 DOID:1920
Sick sinus syndrome contraindication 36083008 DOID:13884
Anaphylaxis contraindication 39579001
Hypokalemia contraindication 43339004
Low blood pressure contraindication 45007003
Sinus bradycardia contraindication 49710005
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Myasthenia gravis contraindication 91637004 DOID:437
Hypomagnesemia contraindication 190855004
Second degree atrioventricular block contraindication 195042002
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Disease of liver contraindication 235856003 DOID:409
Hypoglycemic disorder contraindication 237630007 DOID:9993
Raynaud's phenomenon contraindication 266261006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Pheochromocytoma contraindication 302835009
Peripheral arterial occlusive disease contraindication 399957001
Peripheral vascular disease contraindication 400047006
Poor metabolizer due to cytochrome p450 CYP2D6 variant contraindication 423629005
Azotemia contraindication 445009001
Acute exacerbation of asthma contraindication 708038006
First Degree Atrioventricular Heart Block contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 7.60 WOMBAT-PK CHEMBL
Beta-2 adrenergic receptor GPCR Ki 6.30 WOMBAT-PK
Adrenergic receptor beta GPCR IC50 6.30 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 6.79 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 7.83 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Ki 5 CHEMBL

External reference:

IDSource
DB00264 DRUGBANK_ID
553 IUPHAR_LIGAND_ID
C0350132 UMLSCUI
D00601 KEGG_DRUG
CHEMBL13 ChEMBL_ID
4171 PUBCHEM_CID
4019836 VANDF
6918 RXNORM
372826007 SNOMEDCT_US
7092007 SNOMEDCT_US
d00134 MMSL
N0000007508 NDFRT
N0000147924 NDFRT
003627 NDDF
CHEBI:6904 CHEBI
CHEMBL1200337 ChEMBL_ID
CHEMBL1200898 ChEMBL_ID
CHEMBL1256957 ChEMBL_ID
D008790 MESH_DESCRIPTOR_UI
GEB06NHM23 UNII
3471 INN_ID
80274-67-5 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lopressor HUMAN PRESCRIPTION DRUG LABEL 1 0078-0400 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-0733 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0093-0734 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9660 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0143-9873 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0018 TABLET, FILM COATED 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0032 TABLET, FILM COATED 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-0047 TABLET, FILM COATED 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0424 TABLET 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0434 TABLET 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate and Hydrochlorothiazide HUMAN PRESCRIPTION DRUG LABEL 2 0378-0445 TABLET 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4593 TABLET, FILM COATED 37.50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0378-4594 TABLET, FILM COATED 75 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-1778 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0409-2285 INJECTION, SOLUTION 1 mg INTRAVENOUS ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0462 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0591-0463 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-3552 TABLET 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-3553 TABLET 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-6547 TABLET, FILM COATED 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8016 TABLET, FILM COATED 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8017 TABLET, FILM COATED 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1223 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0781-1228 TABLET, FILM COATED 100 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6162 TABLET, FILM COATED 25 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6340 TABLET 25 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6341 TABLET 50 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 0904-6342 TABLET 100 mg ORAL ANDA 11 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-124 TABLET 50 mg ORAL ANDA 12 sections
Metoprolol Tartrate HUMAN PRESCRIPTION DRUG LABEL 1 10544-263 TABLET, FILM COATED 50 mg ORAL ANDA 12 sections