carmofur indications/contra

Stem definitionDrug idCAS RN
uridine derivatives used as antiviral agents and as antineoplastics 511 61422-45-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 1-hexylcarbamoyl-5-fluorouracil
  • carmofur
  • mifurol
  • yamaful
  • Molecular weight: 257.27
  • Formula: C11H16FN3O3
  • CLOGP: 2.55
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 78.51
  • ALOGS: -3.72
  • ROTB: 5

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC L01BC04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
MeSH PA D000970 Antineoplastic Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Malignant tumor of colon indication 363406005 DOID:219

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.55 acidic
pKa2 13.95 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Cytochrome P450 2D6 Enzyme IC50 5.30 DRUG MATRIX
Mitogen-activated protein kinase 3 Kinase IC50 5.21 DRUG MATRIX
Acid ceramidase Enzyme IC50 7.54 CHEMBL

External reference:

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IDSource
D01784 KEGG_DRUG
2577 PUBCHEM_CID
010893 NDDF
CHEBI:31360 CHEBI
CHEMBL460499 ChEMBL_ID
DB09010 DRUGBANK_ID
HA82M3RAB2 UNII
5042 INN_ID
C017367 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None