Stem definition | Drug id | CAS RN |
---|---|---|
nucleosides antiviral or antineoplastic agents, cytarabine or azacitidine derivatives | 1283 | 95058-81-4 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 8 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 93.90 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 32 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 1 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 1 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
May 15, 1996 | FDA | LILLY | |
June 18, 2019 | PMDA | Eli Lilly Japan K.K. |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Disease progression | 1457.35 | 15.90 | 942 | 41038 | 121816 | 63325226 |
Malignant neoplasm progression | 1185.04 | 15.90 | 714 | 41266 | 81407 | 63365635 |
Thrombocytopenia | 1001.40 | 15.90 | 815 | 41165 | 150342 | 63296700 |
Neutropenia | 725.57 | 15.90 | 725 | 41255 | 174280 | 63272762 |
Thrombotic microangiopathy | 584.83 | 15.90 | 231 | 41749 | 10330 | 63436712 |
Neoplasm progression | 525.10 | 15.90 | 317 | 41663 | 36111 | 63410931 |
Anaemia | 386.25 | 15.90 | 693 | 41287 | 292737 | 63154305 |
Metastases to liver | 362.09 | 15.90 | 214 | 41766 | 23425 | 63423617 |
Myelosuppression | 353.71 | 15.90 | 211 | 41769 | 23492 | 63423550 |
Haematotoxicity | 299.70 | 15.90 | 139 | 41841 | 9237 | 63437805 |
Off label use | 287.40 | 15.90 | 1036 | 40944 | 673426 | 62773616 |
Pancytopenia | 229.34 | 15.90 | 301 | 41679 | 96632 | 63350410 |
Metastases to lung | 220.65 | 15.90 | 125 | 41855 | 12625 | 63434417 |
Metastases to bone | 213.84 | 15.90 | 147 | 41833 | 20872 | 63426170 |
Leukopenia | 204.87 | 15.90 | 254 | 41726 | 77036 | 63370006 |
Platelet count decreased | 204.29 | 15.90 | 313 | 41667 | 115809 | 63331233 |
Diffuse large B-cell lymphoma recurrent | 199.03 | 15.90 | 70 | 41910 | 2250 | 63444792 |
Metastases to lymph nodes | 194.57 | 15.90 | 99 | 41881 | 8059 | 63438983 |
Febrile neutropenia | 187.22 | 15.90 | 304 | 41676 | 118145 | 63328897 |
Ascites | 183.47 | 15.90 | 177 | 41803 | 40551 | 63406491 |
Pleural effusion | 177.82 | 15.90 | 261 | 41719 | 92949 | 63354093 |
Neutrophil count decreased | 170.14 | 15.90 | 198 | 41782 | 56208 | 63390834 |
Death | 165.29 | 15.90 | 583 | 41397 | 373798 | 63073244 |
Pyrexia | 163.71 | 15.90 | 679 | 41301 | 469799 | 62977243 |
Joint swelling | 162.09 | 15.90 | 15 | 41965 | 327651 | 63119391 |
Arthralgia | 160.28 | 15.90 | 89 | 41891 | 569621 | 62877421 |
Rheumatoid arthritis | 153.08 | 15.90 | 3 | 41977 | 253816 | 63193226 |
Biliary tract infection | 143.21 | 15.90 | 41 | 41939 | 661 | 63446381 |
Metastases to peritoneum | 141.92 | 15.90 | 61 | 41919 | 3381 | 63443661 |
Recall phenomenon | 141.78 | 15.90 | 40 | 41940 | 610 | 63446432 |
Bone marrow failure | 138.94 | 15.90 | 131 | 41849 | 29159 | 63417883 |
Acute myeloid leukaemia | 135.72 | 15.90 | 103 | 41877 | 17044 | 63429998 |
Cholangitis | 131.20 | 15.90 | 67 | 41913 | 5494 | 63441548 |
Second primary malignancy | 129.64 | 15.90 | 75 | 41905 | 7878 | 63439164 |
Neuropathy peripheral | 124.79 | 15.90 | 249 | 41731 | 113418 | 63333624 |
Contraindicated product administered | 122.34 | 15.90 | 5 | 41975 | 217643 | 63229399 |
Neurotoxicity | 121.28 | 15.90 | 96 | 41884 | 16894 | 63430148 |
Therapy partial responder | 114.23 | 15.90 | 77 | 41903 | 10581 | 63436461 |
Posterior reversible encephalopathy syndrome | 111.11 | 15.90 | 92 | 41888 | 17253 | 63429789 |
Capillary leak syndrome | 110.91 | 15.90 | 45 | 41935 | 2155 | 63444887 |
Maternal exposure during pregnancy | 108.95 | 15.90 | 10 | 41970 | 220052 | 63226990 |
Haemolytic uraemic syndrome | 108.62 | 15.90 | 46 | 41934 | 2457 | 63444585 |
Cytopenia | 108.32 | 15.90 | 77 | 41903 | 11524 | 63435518 |
Cytokine release syndrome | 106.75 | 15.90 | 83 | 41897 | 14231 | 63432811 |
Product dose omission issue | 102.84 | 15.90 | 16 | 41964 | 234297 | 63212745 |
Systemic lupus erythematosus | 102.08 | 15.90 | 10 | 41970 | 208908 | 63238134 |
Hypertransaminasaemia | 101.58 | 15.90 | 60 | 41920 | 6549 | 63440493 |
Sepsis | 98.40 | 15.90 | 272 | 41708 | 152851 | 63294191 |
Fall | 96.84 | 15.90 | 71 | 41909 | 392263 | 63054779 |
Mucosal inflammation | 96.13 | 15.90 | 136 | 41844 | 46792 | 63400250 |
Swelling | 92.99 | 15.90 | 33 | 41947 | 275345 | 63171697 |
Abdominal discomfort | 91.68 | 15.90 | 49 | 41931 | 320836 | 63126206 |
Palmar-plantar erythrodysaesthesia syndrome | 85.25 | 15.90 | 90 | 41890 | 22925 | 63424117 |
Headache | 84.91 | 15.90 | 183 | 41797 | 633058 | 62813984 |
Hepatic failure | 83.09 | 15.90 | 110 | 41870 | 35546 | 63411496 |
Arthropathy | 82.99 | 15.90 | 26 | 41954 | 234766 | 63212276 |
Wound | 81.92 | 15.90 | 7 | 41973 | 163256 | 63283786 |
Lymphoma | 80.89 | 15.90 | 66 | 41914 | 12121 | 63434921 |
Weight increased | 80.27 | 15.90 | 36 | 41944 | 260756 | 63186286 |
Blood lactate dehydrogenase increased | 79.64 | 15.90 | 87 | 41893 | 23029 | 63424013 |
Therapeutic product effect decreased | 78.65 | 15.90 | 16 | 41964 | 193171 | 63253871 |
Pulmonary embolism | 78.65 | 15.90 | 211 | 41769 | 116473 | 63330569 |
Nasopharyngitis | 78.40 | 15.90 | 35 | 41945 | 254222 | 63192820 |
Abdominal pain | 77.46 | 15.90 | 391 | 41589 | 293065 | 63153977 |
Drug hypersensitivity | 76.91 | 15.90 | 56 | 41924 | 310631 | 63136411 |
Musculoskeletal stiffness | 75.76 | 15.90 | 15 | 41965 | 184603 | 63262439 |
Diffuse large B-cell lymphoma refractory | 75.47 | 15.90 | 29 | 41951 | 1201 | 63445841 |
Metastases to central nervous system | 74.68 | 15.90 | 65 | 41915 | 13040 | 63434002 |
Sinusitis | 73.41 | 15.90 | 29 | 41951 | 226624 | 63220418 |
Pain | 73.00 | 15.90 | 249 | 41731 | 740379 | 62706663 |
Vomiting | 72.36 | 15.90 | 623 | 41357 | 558994 | 62888048 |
Tumour lysis syndrome | 68.93 | 15.90 | 53 | 41927 | 8937 | 63438105 |
Alopecia | 68.87 | 15.90 | 73 | 41907 | 337463 | 63109579 |
Polyneuropathy | 68.69 | 15.90 | 65 | 41915 | 14524 | 63432518 |
PIK3CA-activated mutation | 68.68 | 15.90 | 26 | 41954 | 1033 | 63446009 |
Neutropenic sepsis | 67.59 | 15.90 | 68 | 41912 | 16370 | 63430672 |
Myositis | 67.51 | 15.90 | 53 | 41927 | 9213 | 63437829 |
General physical health deterioration | 66.83 | 15.90 | 287 | 41693 | 201115 | 63245927 |
Peripheral swelling | 65.72 | 15.90 | 48 | 41932 | 265894 | 63181148 |
Myelodysplastic syndrome | 64.70 | 15.90 | 67 | 41913 | 16687 | 63430355 |
Cholangitis infective | 64.15 | 15.90 | 19 | 41961 | 347 | 63446695 |
Disease recurrence | 63.05 | 15.90 | 85 | 41895 | 27945 | 63419097 |
Asthma | 62.56 | 15.90 | 6 | 41974 | 127555 | 63319487 |
Lower respiratory tract infection | 58.09 | 15.90 | 9 | 41971 | 132298 | 63314744 |
Pericarditis | 57.66 | 15.90 | 9 | 41971 | 131570 | 63315472 |
Hepatotoxicity | 56.97 | 15.90 | 94 | 41886 | 36947 | 63410095 |
Pericardial effusion | 55.56 | 15.90 | 83 | 41897 | 29975 | 63417067 |
Breast cancer metastatic | 55.54 | 15.90 | 53 | 41927 | 11965 | 63435077 |
Breast cancer recurrent | 55.42 | 15.90 | 35 | 41945 | 4306 | 63442736 |
Ovarian cancer recurrent | 55.41 | 15.90 | 22 | 41958 | 995 | 63446047 |
Metastases to pleura | 55.35 | 15.90 | 25 | 41955 | 1560 | 63445482 |
Exposure during pregnancy | 55.34 | 15.90 | 17 | 41963 | 155530 | 63291512 |
Metastasis | 54.38 | 15.90 | 37 | 41943 | 5160 | 63441882 |
Microangiopathic haemolytic anaemia | 54.21 | 15.90 | 19 | 41961 | 604 | 63446438 |
Drug resistance | 53.81 | 15.90 | 71 | 41909 | 22862 | 63424180 |
Dehydration | 52.91 | 15.90 | 241 | 41739 | 173113 | 63273929 |
Pneumonitis | 52.32 | 15.90 | 88 | 41892 | 35134 | 63411908 |
Hepatic enzyme increased | 50.64 | 15.90 | 36 | 41944 | 202292 | 63244750 |
Arthritis | 50.63 | 15.90 | 8 | 41972 | 115913 | 63331129 |
Acquired gene mutation | 49.19 | 15.90 | 20 | 41960 | 963 | 63446079 |
Metastases to skin | 48.04 | 15.90 | 23 | 41957 | 1640 | 63445402 |
Product use issue | 48.03 | 15.90 | 45 | 41935 | 220475 | 63226567 |
Haemoglobin decreased | 47.97 | 15.90 | 207 | 41773 | 145278 | 63301764 |
Bile duct stenosis | 47.67 | 15.90 | 21 | 41959 | 1235 | 63445807 |
Contusion | 47.26 | 15.90 | 20 | 41960 | 150024 | 63297018 |
Hypoalbuminaemia | 47.01 | 15.90 | 48 | 41932 | 11757 | 63435285 |
Thrombotic thrombocytopenic purpura | 46.66 | 15.90 | 30 | 41950 | 3806 | 63443236 |
Small intestinal obstruction | 46.51 | 15.90 | 59 | 41921 | 18278 | 63428764 |
Memory impairment | 45.97 | 15.90 | 7 | 41973 | 104251 | 63342791 |
Overdose | 45.85 | 15.90 | 10 | 41970 | 115068 | 63331974 |
White blood cell count decreased | 45.16 | 15.90 | 197 | 41783 | 138907 | 63308135 |
Injection site pain | 44.72 | 15.90 | 15 | 41965 | 129785 | 63317257 |
Peripheral ischaemia | 44.67 | 15.90 | 32 | 41948 | 4846 | 63442196 |
Embolism | 44.62 | 15.90 | 39 | 41941 | 7867 | 63439175 |
Proteinuria | 44.50 | 15.90 | 59 | 41921 | 19086 | 63427956 |
Injection site erythema | 43.30 | 15.90 | 3 | 41977 | 83171 | 63363871 |
Psoriatic arthropathy | 43.08 | 15.90 | 5 | 41975 | 91515 | 63355527 |
Cholestasis | 43.00 | 15.90 | 73 | 41907 | 29361 | 63417681 |
Discomfort | 42.91 | 15.90 | 29 | 41951 | 167345 | 63279697 |
Neutropenic infection | 42.84 | 15.90 | 20 | 41960 | 1347 | 63445695 |
Sleep disorder | 42.30 | 15.90 | 3 | 41977 | 81563 | 63365479 |
Pancreatic carcinoma metastatic | 42.17 | 15.90 | 23 | 41957 | 2155 | 63444887 |
Urinary tract obstruction | 41.88 | 15.90 | 23 | 41957 | 2185 | 63444857 |
Interstitial lung disease | 40.72 | 15.90 | 111 | 41869 | 61797 | 63385245 |
BRCA2 gene mutation | 40.46 | 15.90 | 10 | 41970 | 88 | 63446954 |
Bronchitis | 40.40 | 15.90 | 16 | 41964 | 124919 | 63322123 |
Atypical haemolytic uraemic syndrome | 40.40 | 15.90 | 16 | 41964 | 719 | 63446323 |
Insomnia | 40.12 | 15.90 | 50 | 41930 | 215202 | 63231840 |
Pancreatic fistula | 39.93 | 15.90 | 7 | 41973 | 6 | 63447036 |
Cerebral ischaemia | 39.61 | 15.90 | 34 | 41946 | 6694 | 63440348 |
Migraine | 39.16 | 15.90 | 10 | 41970 | 103336 | 63343706 |
Capillary permeability increased | 39.02 | 15.90 | 8 | 41972 | 26 | 63447016 |
Muscle spasms | 38.78 | 15.90 | 28 | 41952 | 156122 | 63290920 |
Erythema | 38.69 | 15.90 | 223 | 41757 | 175528 | 63271514 |
Dry gangrene | 38.50 | 15.90 | 15 | 41965 | 645 | 63446397 |
Mobility decreased | 38.39 | 15.90 | 16 | 41964 | 121143 | 63325899 |
Metastases to meninges | 38.36 | 15.90 | 23 | 41957 | 2579 | 63444463 |
Urticaria | 38.30 | 15.90 | 32 | 41948 | 165770 | 63281272 |
Somnolence | 38.27 | 15.90 | 37 | 41943 | 178648 | 63268394 |
Product use in unapproved indication | 37.98 | 15.90 | 225 | 41755 | 178855 | 63268187 |
Loss of personal independence in daily activities | 37.67 | 15.90 | 9 | 41971 | 97281 | 63349761 |
Hormone receptor positive breast cancer | 37.62 | 15.90 | 14 | 41966 | 530 | 63446512 |
EGFR gene mutation | 37.55 | 15.90 | 12 | 41968 | 285 | 63446757 |
Jaundice | 36.86 | 15.90 | 68 | 41912 | 29183 | 63417859 |
Pseudocellulitis | 36.57 | 15.90 | 7 | 41973 | 14 | 63447028 |
Metastases to chest wall | 36.45 | 15.90 | 14 | 41966 | 579 | 63446463 |
Blood cholesterol increased | 35.82 | 15.90 | 9 | 41971 | 94023 | 63353019 |
Asthenia | 35.66 | 15.90 | 399 | 41581 | 383205 | 63063837 |
Folliculitis | 35.30 | 15.90 | 3 | 41977 | 70314 | 63376728 |
Hyperbilirubinaemia | 34.55 | 15.90 | 40 | 41940 | 11274 | 63435768 |
Anxiety | 34.17 | 15.90 | 57 | 41923 | 217484 | 63229558 |
Gait disturbance | 33.66 | 15.90 | 43 | 41937 | 183135 | 63263907 |
Peripheral sensory neuropathy | 32.81 | 15.90 | 32 | 41948 | 7419 | 63439623 |
Laryngospasm | 32.74 | 15.90 | 22 | 41958 | 3006 | 63444036 |
Carcinoembryonic antigen increased | 32.42 | 15.90 | 18 | 41962 | 1747 | 63445295 |
Muscle injury | 32.22 | 15.90 | 3 | 41977 | 65342 | 63381700 |
Cardiac cirrhosis | 32.16 | 15.90 | 9 | 41971 | 133 | 63446909 |
Thrombophlebitis migrans | 32.16 | 15.90 | 9 | 41971 | 133 | 63446909 |
Myelitis transverse | 32.12 | 15.90 | 16 | 41964 | 1244 | 63445798 |
Injury | 32.10 | 15.90 | 5 | 41975 | 73242 | 63373800 |
Toxic erythema of chemotherapy | 31.97 | 15.90 | 9 | 41971 | 136 | 63446906 |
Colitis | 31.90 | 15.90 | 87 | 41893 | 48441 | 63398601 |
Drug interaction | 31.59 | 15.90 | 65 | 41915 | 229066 | 63217976 |
Feeling abnormal | 31.46 | 15.90 | 31 | 41949 | 148361 | 63298681 |
Deep vein thrombosis | 31.35 | 15.90 | 124 | 41856 | 83676 | 63363366 |
Wheezing | 31.30 | 15.90 | 12 | 41968 | 95583 | 63351459 |
Blister | 31.30 | 15.90 | 24 | 41956 | 129790 | 63317252 |
Hypokalaemia | 30.67 | 15.90 | 143 | 41837 | 103661 | 63343381 |
Subacute cutaneous lupus erythematosus | 30.50 | 15.90 | 20 | 41960 | 2623 | 63444419 |
Suicidal ideation | 30.43 | 15.90 | 3 | 41977 | 62418 | 63384624 |
Depression | 30.38 | 15.90 | 52 | 41928 | 196440 | 63250602 |
Epistaxis | 29.99 | 15.90 | 111 | 41869 | 72614 | 63374428 |
Treatment failure | 29.58 | 15.90 | 54 | 41926 | 198989 | 63248053 |
Suicide attempt | 29.51 | 15.90 | 3 | 41977 | 60915 | 63386127 |
Granulocyte count decreased | 29.42 | 15.90 | 15 | 41965 | 1225 | 63445817 |
Device occlusion | 29.35 | 15.90 | 30 | 41950 | 7357 | 63439685 |
Tumour associated fever | 28.12 | 15.90 | 10 | 41970 | 332 | 63446710 |
Osteoarthritis | 28.01 | 15.90 | 14 | 41966 | 95329 | 63351713 |
Adverse drug reaction | 27.82 | 15.90 | 9 | 41971 | 79705 | 63367337 |
Acute erythroid leukaemia | 27.61 | 15.90 | 7 | 41973 | 69 | 63446973 |
Condition aggravated | 27.42 | 15.90 | 155 | 41825 | 402062 | 63044980 |
Carbohydrate antigen 125 increased | 27.00 | 15.90 | 19 | 41961 | 2797 | 63444245 |
Decreased appetite | 26.98 | 15.90 | 269 | 41711 | 250783 | 63196259 |
Paraneoplastic pemphigus | 26.91 | 15.90 | 7 | 41973 | 77 | 63446965 |
Performance status decreased | 26.71 | 15.90 | 21 | 41959 | 3657 | 63443385 |
Carbohydrate antigen 19-9 increased | 26.69 | 15.90 | 9 | 41971 | 254 | 63446788 |
Gastrointestinal toxicity | 26.42 | 15.90 | 29 | 41951 | 7712 | 63439330 |
Impaired healing | 25.96 | 15.90 | 18 | 41962 | 102524 | 63344518 |
Metastatic neoplasm | 25.88 | 15.90 | 22 | 41958 | 4273 | 63442769 |
Injection site reaction | 25.63 | 15.90 | 4 | 41976 | 58520 | 63388522 |
Metastases to bone marrow | 25.19 | 15.90 | 10 | 41970 | 452 | 63446590 |
Skin mass | 25.15 | 15.90 | 25 | 41955 | 5930 | 63441112 |
Infusion related reaction | 25.11 | 15.90 | 81 | 41899 | 245440 | 63201602 |
Influenza | 25.08 | 15.90 | 21 | 41959 | 108701 | 63338341 |
Hepatic cytolysis | 24.91 | 15.90 | 40 | 41940 | 15367 | 63431675 |
Hyperpyrexia | 24.80 | 15.90 | 20 | 41960 | 3612 | 63443430 |
Dizziness | 24.52 | 15.90 | 175 | 41805 | 429750 | 63017292 |
Nausea | 24.50 | 15.90 | 738 | 41242 | 853733 | 62593309 |
Blood disorder | 24.22 | 15.90 | 26 | 41954 | 6745 | 63440297 |
Generalised oedema | 24.13 | 15.90 | 40 | 41940 | 15778 | 63431264 |
Pain in extremity | 24.09 | 15.90 | 125 | 41855 | 331361 | 63115681 |
Catabolic state | 23.77 | 15.90 | 6 | 41974 | 58 | 63446984 |
Haemoglobinaemia | 23.59 | 15.90 | 6 | 41974 | 60 | 63446982 |
Intestinal perforation | 23.50 | 15.90 | 34 | 41946 | 11929 | 63435113 |
Pneumocystis jirovecii pneumonia | 23.46 | 15.90 | 41 | 41939 | 16873 | 63430169 |
Oedema peripheral | 23.31 | 15.90 | 209 | 41771 | 189302 | 63257740 |
Extremity necrosis | 23.11 | 15.90 | 14 | 41966 | 1599 | 63445443 |
Portal vein occlusion | 23.05 | 15.90 | 4 | 41976 | 3 | 63447039 |
Rash | 22.84 | 15.90 | 249 | 41731 | 560622 | 62886420 |
Hospitalisation | 22.81 | 15.90 | 14 | 41966 | 85067 | 63361975 |
Cardiotoxicity | 22.75 | 15.90 | 28 | 41952 | 8410 | 63438632 |
Mediastinum neoplasm | 22.67 | 15.90 | 6 | 41974 | 71 | 63446971 |
Neoplasm | 22.48 | 15.90 | 26 | 41954 | 7319 | 63439723 |
Systemic infection | 22.39 | 15.90 | 21 | 41959 | 4639 | 63442403 |
Gait inability | 22.35 | 15.90 | 4 | 41976 | 52955 | 63394087 |
Bacillus infection | 22.24 | 15.90 | 11 | 41969 | 842 | 63446200 |
Skin toxicity | 22.18 | 15.90 | 21 | 41959 | 4693 | 63442349 |
Neutrophil count abnormal | 22.06 | 15.90 | 17 | 41963 | 2875 | 63444167 |
Wrong technique in product usage process | 21.82 | 15.90 | 7 | 41973 | 62333 | 63384709 |
Hepatic lesion | 21.77 | 15.90 | 21 | 41959 | 4804 | 63442238 |
Pulmonary toxicity | 21.76 | 15.90 | 29 | 41951 | 9426 | 63437616 |
Leukaemic lymphoma | 21.74 | 15.90 | 6 | 41974 | 84 | 63446958 |
Metastases to diaphragm | 21.63 | 15.90 | 5 | 41975 | 32 | 63447010 |
Lymphangitis | 21.60 | 15.90 | 11 | 41969 | 896 | 63446146 |
Injection site swelling | 21.42 | 15.90 | 3 | 41977 | 47569 | 63399473 |
Gastrointestinal perforation | 21.28 | 15.90 | 18 | 41962 | 3473 | 63443569 |
Adverse event | 21.27 | 15.90 | 9 | 41971 | 67550 | 63379492 |
Gastric neoplasm | 21.22 | 15.90 | 8 | 41972 | 314 | 63446728 |
IIIrd nerve paralysis | 21.22 | 15.90 | 10 | 41970 | 688 | 63446354 |
Vaginal cellulitis | 21.17 | 15.90 | 6 | 41974 | 93 | 63446949 |
Splenic marginal zone lymphoma | 21.11 | 15.90 | 5 | 41975 | 36 | 63447006 |
Stress | 21.06 | 15.90 | 9 | 41971 | 67158 | 63379884 |
Peritoneal disorder | 21.03 | 15.90 | 9 | 41971 | 493 | 63446549 |
Hypocalcaemia | 20.99 | 15.90 | 57 | 41923 | 31656 | 63415386 |
Immune-mediated hepatic disorder | 20.81 | 15.90 | 9 | 41971 | 506 | 63446536 |
Drug ineffective | 20.68 | 15.90 | 530 | 41450 | 1044235 | 62402807 |
Blood pressure fluctuation | 20.67 | 15.90 | 3 | 41977 | 46314 | 63400728 |
Metastases to adrenals | 20.35 | 15.90 | 10 | 41970 | 755 | 63446287 |
Metastases to bladder | 20.20 | 15.90 | 7 | 41973 | 215 | 63446827 |
Hypercalcaemia of malignancy | 20.14 | 15.90 | 7 | 41973 | 217 | 63446825 |
Gastrointestinal disorder | 20.03 | 15.90 | 35 | 41945 | 131204 | 63315838 |
Cognitive disorder | 20.02 | 15.90 | 6 | 41974 | 55809 | 63391233 |
Metastases to stomach | 19.90 | 15.90 | 7 | 41973 | 225 | 63446817 |
Myocardial infarction | 19.89 | 15.90 | 22 | 41958 | 99871 | 63347171 |
Tumour marker abnormal | 19.80 | 15.90 | 8 | 41972 | 379 | 63446663 |
Biliary obstruction | 19.76 | 15.90 | 16 | 41964 | 2905 | 63444137 |
Adenosquamous cell lung cancer stage IV | 19.75 | 15.90 | 4 | 41976 | 12 | 63447030 |
Metastases to abdominal wall | 19.65 | 15.90 | 6 | 41974 | 122 | 63446920 |
Hypomagnesaemia | 19.36 | 15.90 | 52 | 41928 | 28685 | 63418357 |
Vena cava thrombosis | 19.23 | 15.90 | 14 | 41966 | 2173 | 63444869 |
Ureteric fistula | 19.07 | 15.90 | 4 | 41976 | 15 | 63447027 |
Neoplasm recurrence | 19.02 | 15.90 | 15 | 41965 | 2623 | 63444419 |
Pseudosepsis | 18.97 | 15.90 | 3 | 41977 | 0 | 63447042 |
Paresis cranial nerve | 18.97 | 15.90 | 3 | 41977 | 0 | 63447042 |
Paraneoplastic dermatomyositis | 18.86 | 15.90 | 4 | 41976 | 16 | 63447026 |
Retinopathy | 18.85 | 15.90 | 16 | 41964 | 3103 | 63443939 |
Acute kidney injury | 18.83 | 15.90 | 261 | 41719 | 263154 | 63183888 |
Stress cardiomyopathy | 18.77 | 15.90 | 27 | 41953 | 9423 | 63437619 |
Febrile infection | 18.50 | 15.90 | 12 | 41968 | 1545 | 63445497 |
Pancreatic carcinoma | 18.49 | 15.90 | 24 | 41956 | 7604 | 63439438 |
Lymphoedema | 18.42 | 15.90 | 30 | 41950 | 11662 | 63435380 |
Bone marrow infiltration | 18.37 | 15.90 | 9 | 41971 | 675 | 63446367 |
Tumour thrombosis | 18.30 | 15.90 | 4 | 41976 | 19 | 63447023 |
Intestinal metastasis | 18.30 | 15.90 | 6 | 41974 | 155 | 63446887 |
Metastases to spine | 18.28 | 15.90 | 16 | 41964 | 3233 | 63443809 |
Bronchostenosis | 18.17 | 15.90 | 8 | 41972 | 470 | 63446572 |
Blast cells present | 18.14 | 15.90 | 8 | 41972 | 472 | 63446570 |
Metastases to spleen | 18.12 | 15.90 | 6 | 41974 | 160 | 63446882 |
Medication error | 18.07 | 15.90 | 6 | 41974 | 52278 | 63394764 |
Heart rate decreased | 18.06 | 15.90 | 4 | 41976 | 45556 | 63401486 |
Joint stiffness | 18.03 | 15.90 | 3 | 41977 | 41866 | 63405176 |
Chills | 17.69 | 15.90 | 132 | 41848 | 113246 | 63333796 |
Jaundice cholestatic | 17.68 | 15.90 | 23 | 41957 | 7301 | 63439741 |
Disseminated intravascular coagulation | 17.68 | 15.90 | 39 | 41941 | 19012 | 63428030 |
Febrile bone marrow aplasia | 17.68 | 15.90 | 23 | 41957 | 7302 | 63439740 |
Postictal state | 17.43 | 15.90 | 10 | 41970 | 1033 | 63446009 |
Cholangitis acute | 17.40 | 15.90 | 8 | 41972 | 520 | 63446522 |
Obstruction gastric | 17.40 | 15.90 | 10 | 41970 | 1037 | 63446005 |
Hepatic function abnormal | 17.28 | 15.90 | 59 | 41921 | 37083 | 63409959 |
Renal salt-wasting syndrome | 17.25 | 15.90 | 7 | 41973 | 335 | 63446707 |
Fluid retention | 17.17 | 15.90 | 9 | 41971 | 59677 | 63387365 |
Red blood cell sedimentation rate increased | 17.15 | 15.90 | 4 | 41976 | 43978 | 63403064 |
Blood pressure increased | 16.88 | 15.90 | 53 | 41927 | 162009 | 63285033 |
Pulmonary alveolar haemorrhage | 16.83 | 15.90 | 18 | 41962 | 4650 | 63442392 |
Purtscher retinopathy | 16.80 | 15.90 | 5 | 41975 | 93 | 63446949 |
Post thrombotic syndrome | 16.73 | 15.90 | 8 | 41972 | 569 | 63446473 |
Hyperphosphataemia | 16.68 | 15.90 | 13 | 41967 | 2235 | 63444807 |
Urinary tract infection enterococcal | 16.56 | 15.90 | 14 | 41966 | 2699 | 63444343 |
Left ventricular dysfunction | 16.55 | 15.90 | 29 | 41951 | 11959 | 63435083 |
Ischaemia | 16.50 | 15.90 | 18 | 41962 | 4754 | 63442288 |
Oroticaciduria | 16.43 | 15.90 | 3 | 41977 | 4 | 63447038 |
Localised oedema | 16.40 | 15.90 | 19 | 41961 | 5359 | 63441683 |
Malaise | 16.38 | 15.90 | 186 | 41794 | 415768 | 63031274 |
Hydronephrosis | 16.31 | 15.90 | 27 | 41953 | 10635 | 63436407 |
Sedation | 16.23 | 15.90 | 3 | 41977 | 38806 | 63408236 |
Renal vein thrombosis | 16.16 | 15.90 | 7 | 41973 | 395 | 63446647 |
Ovarian cancer metastatic | 16.07 | 15.90 | 9 | 41971 | 888 | 63446154 |
Nasal congestion | 16.00 | 15.90 | 12 | 41968 | 65648 | 63381394 |
Malignant ascites | 15.99 | 15.90 | 9 | 41971 | 897 | 63446145 |
Rhinorrhoea | 15.96 | 15.90 | 12 | 41968 | 65565 | 63381477 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Disease progression | 1228.38 | 17.28 | 973 | 36284 | 107104 | 34812570 |
Thrombocytopenia | 640.26 | 17.28 | 808 | 36449 | 155439 | 34764235 |
Thrombotic microangiopathy | 417.93 | 17.28 | 211 | 37046 | 10419 | 34909255 |
Malignant neoplasm progression | 386.24 | 17.28 | 472 | 36785 | 87574 | 34832100 |
Neutropenia | 362.79 | 17.28 | 620 | 36637 | 156158 | 34763516 |
Myelosuppression | 308.64 | 17.28 | 214 | 37043 | 19051 | 34900623 |
Neoplasm progression | 307.36 | 17.28 | 230 | 37027 | 23070 | 34896604 |
Anaemia | 280.07 | 17.28 | 704 | 36553 | 232631 | 34687043 |
Off label use | 273.66 | 17.28 | 1021 | 36236 | 418503 | 34501171 |
Pancytopenia | 251.51 | 17.28 | 400 | 36857 | 94757 | 34824917 |
Febrile neutropenia | 197.33 | 17.28 | 444 | 36813 | 136405 | 34783269 |
Cholangitis | 191.72 | 17.28 | 118 | 37139 | 8571 | 34911103 |
Diffuse large B-cell lymphoma recurrent | 191.13 | 17.28 | 85 | 37172 | 3143 | 34916531 |
Pyrexia | 182.05 | 17.28 | 768 | 36489 | 332245 | 34587429 |
Leukopenia | 171.10 | 17.28 | 268 | 36989 | 62588 | 34857086 |
Haematotoxicity | 155.10 | 17.28 | 101 | 37156 | 8093 | 34911581 |
Cytokine release syndrome | 136.31 | 17.28 | 144 | 37113 | 22733 | 34896941 |
Therapy partial responder | 135.88 | 17.28 | 99 | 37158 | 9517 | 34910157 |
Haemolytic uraemic syndrome | 125.17 | 17.28 | 57 | 37200 | 2229 | 34917445 |
Neuropathy peripheral | 117.38 | 17.28 | 268 | 36989 | 82995 | 34836679 |
General physical health deterioration | 117.30 | 17.28 | 351 | 36906 | 127918 | 34791756 |
Neutrophil count decreased | 102.11 | 17.28 | 190 | 37067 | 50914 | 34868760 |
Pneumonitis | 101.33 | 17.28 | 151 | 37106 | 33727 | 34885947 |
Diffuse large B-cell lymphoma refractory | 100.34 | 17.28 | 41 | 37216 | 1225 | 34918449 |
Neutropenic sepsis | 99.08 | 17.28 | 96 | 37161 | 13671 | 34906003 |
Product dose omission issue | 97.63 | 17.28 | 8 | 37249 | 119703 | 34799971 |
Platelet count decreased | 91.46 | 17.28 | 308 | 36949 | 119409 | 34800265 |
Bacteraemia | 89.90 | 17.28 | 108 | 37149 | 19609 | 34900065 |
Biliary tract infection | 83.53 | 17.28 | 30 | 37227 | 625 | 34919049 |
Interstitial lung disease | 83.11 | 17.28 | 202 | 37055 | 65080 | 34854594 |
Pseudocellulitis | 79.76 | 17.28 | 17 | 37240 | 37 | 34919637 |
Liver abscess | 78.61 | 17.28 | 50 | 37207 | 3845 | 34915829 |
Neurotoxicity | 74.60 | 17.28 | 94 | 37163 | 17916 | 34901758 |
Arthralgia | 72.40 | 17.28 | 46 | 37211 | 169995 | 34749679 |
Capillary leak syndrome | 72.05 | 17.28 | 39 | 37218 | 2219 | 34917455 |
Sepsis | 70.37 | 17.28 | 357 | 36900 | 166204 | 34753470 |
Drug interaction | 68.68 | 17.28 | 84 | 37173 | 225862 | 34693812 |
Bone marrow failure | 67.69 | 17.28 | 116 | 37141 | 29137 | 34890537 |
Product use in unapproved indication | 67.65 | 17.28 | 276 | 36981 | 117223 | 34802451 |
Pancreatic carcinoma metastatic | 65.02 | 17.28 | 40 | 37217 | 2900 | 34916774 |
Metastases to liver | 62.54 | 17.28 | 75 | 37182 | 13588 | 34906086 |
Overdose | 60.06 | 17.28 | 12 | 37245 | 91047 | 34828627 |
Pulmonary embolism | 57.44 | 17.28 | 218 | 37039 | 89528 | 34830146 |
Pancreatic enzyme abnormality | 57.33 | 17.28 | 14 | 37243 | 67 | 34919607 |
Hypertransaminasaemia | 55.94 | 17.28 | 47 | 37210 | 5559 | 34914115 |
Pleural effusion | 54.61 | 17.28 | 201 | 37056 | 81345 | 34838329 |
Headache | 54.44 | 17.28 | 81 | 37176 | 200554 | 34719120 |
Fall | 54.00 | 17.28 | 83 | 37174 | 202802 | 34716872 |
Seizure | 52.50 | 17.28 | 23 | 37234 | 104834 | 34814840 |
Nasopharyngitis | 51.07 | 17.28 | 7 | 37250 | 69961 | 34849713 |
Disease recurrence | 50.74 | 17.28 | 86 | 37171 | 21404 | 34898270 |
Peripheral ischaemia | 49.30 | 17.28 | 44 | 37213 | 5643 | 34914031 |
Metastases to lung | 49.09 | 17.28 | 55 | 37202 | 9265 | 34910409 |
Drug hypersensitivity | 48.36 | 17.28 | 13 | 37244 | 80516 | 34839158 |
Biliary obstruction | 47.49 | 17.28 | 32 | 37225 | 2713 | 34916961 |
Myositis | 46.84 | 17.28 | 61 | 37196 | 12009 | 34907665 |
Pulmonary toxicity | 46.37 | 17.28 | 44 | 37213 | 6103 | 34913571 |
Immune-mediated hepatitis | 46.11 | 17.28 | 29 | 37228 | 2186 | 34917488 |
Feeling abnormal | 44.59 | 17.28 | 7 | 37250 | 63228 | 34856446 |
Cytopenia | 44.32 | 17.28 | 61 | 37196 | 12662 | 34907012 |
Asthenia | 43.34 | 17.28 | 425 | 36832 | 244826 | 34674848 |
Hyperpyrexia | 42.35 | 17.28 | 30 | 37227 | 2758 | 34916916 |
Atypical haemolytic uraemic syndrome | 41.87 | 17.28 | 15 | 37242 | 310 | 34919364 |
Insomnia | 41.65 | 17.28 | 30 | 37227 | 103877 | 34815797 |
Blood lactate dehydrogenase increased | 41.60 | 17.28 | 82 | 37175 | 22908 | 34896766 |
Pancreatic carcinoma | 40.96 | 17.28 | 49 | 37208 | 8852 | 34910822 |
Metastases to central nervous system | 40.80 | 17.28 | 47 | 37210 | 8158 | 34911516 |
Anxiety | 40.79 | 17.28 | 28 | 37229 | 99400 | 34820274 |
Depression | 40.29 | 17.28 | 27 | 37230 | 97071 | 34822603 |
Enterocolitis infectious | 39.89 | 17.28 | 24 | 37233 | 1671 | 34918003 |
Myalgia | 39.71 | 17.28 | 20 | 37237 | 84090 | 34835584 |
Chills | 39.40 | 17.28 | 181 | 37076 | 80862 | 34838812 |
Lymphoma | 39.18 | 17.28 | 57 | 37200 | 12450 | 34907224 |
Vomiting | 38.46 | 17.28 | 418 | 36839 | 247203 | 34672471 |
Ascites | 37.42 | 17.28 | 122 | 37135 | 46449 | 34873225 |
Weight increased | 37.10 | 17.28 | 27 | 37230 | 93006 | 34826668 |
Recall phenomenon | 36.92 | 17.28 | 16 | 37241 | 555 | 34919119 |
Muscle spasms | 36.67 | 17.28 | 17 | 37240 | 74984 | 34844690 |
Deep vein thrombosis | 36.49 | 17.28 | 152 | 37105 | 65096 | 34854578 |
Decreased appetite | 35.79 | 17.28 | 301 | 36956 | 166091 | 34753583 |
Mucosal inflammation | 35.48 | 17.28 | 106 | 37151 | 38516 | 34881158 |
Unmasking of previously unidentified disease | 35.48 | 17.28 | 18 | 37239 | 896 | 34918778 |
Urosepsis | 35.35 | 17.28 | 55 | 37202 | 12744 | 34906930 |
Joint swelling | 35.33 | 17.28 | 10 | 37247 | 59880 | 34859794 |
Right ventricular ejection fraction decreased | 35.15 | 17.28 | 9 | 37248 | 54 | 34919620 |
Bicytopenia | 34.71 | 17.28 | 25 | 37232 | 2359 | 34917315 |
Blood pressure increased | 34.57 | 17.28 | 26 | 37231 | 88076 | 34831598 |
Lymphadenopathy | 33.99 | 17.28 | 86 | 37171 | 28377 | 34891297 |
Nausea | 33.93 | 17.28 | 529 | 36728 | 339379 | 34580295 |
White blood cell count decreased | 33.73 | 17.28 | 195 | 37062 | 95250 | 34824424 |
Hospitalisation | 32.66 | 17.28 | 10 | 37247 | 56892 | 34862782 |
Skin toxicity | 31.88 | 17.28 | 32 | 37225 | 4752 | 34914922 |
Chronic myelomonocytic leukaemia | 31.73 | 17.28 | 15 | 37242 | 639 | 34919035 |
Biliary sepsis | 30.83 | 17.28 | 15 | 37242 | 682 | 34918992 |
Vena cava thrombosis | 30.58 | 17.28 | 18 | 37239 | 1204 | 34918470 |
Coronary artery disease | 30.54 | 17.28 | 7 | 37250 | 48298 | 34871376 |
Electrocardiogram QT prolonged | 30.11 | 17.28 | 4 | 37253 | 40948 | 34878726 |
Device occlusion | 30.07 | 17.28 | 36 | 37221 | 6509 | 34913165 |
Toxicity to various agents | 30.06 | 17.28 | 111 | 37146 | 200251 | 34719423 |
Bradycardia | 29.92 | 17.28 | 22 | 37235 | 75396 | 34844278 |
Microangiopathic haemolytic anaemia | 29.79 | 17.28 | 16 | 37241 | 896 | 34918778 |
Agitation | 29.66 | 17.28 | 12 | 37245 | 57387 | 34862287 |
Hepatocellular injury | 29.59 | 17.28 | 70 | 37187 | 22141 | 34897533 |
Pancreatic carcinoma recurrent | 29.36 | 17.28 | 8 | 37249 | 63 | 34919611 |
Tremor | 29.16 | 17.28 | 27 | 37230 | 82560 | 34837114 |
Histiocytic necrotising lymphadenitis | 28.49 | 17.28 | 6 | 37251 | 12 | 34919662 |
Embolism | 27.97 | 17.28 | 38 | 37219 | 7791 | 34911883 |
Discontinued product administered | 27.29 | 17.28 | 6 | 37251 | 16 | 34919658 |
Extremity necrosis | 27.17 | 17.28 | 20 | 37237 | 1952 | 34917722 |
Ill-defined disorder | 26.86 | 17.28 | 51 | 37206 | 13858 | 34905816 |
Dermatitis acneiform | 26.74 | 17.28 | 33 | 37224 | 6156 | 34913518 |
Cardiac failure congestive | 26.26 | 17.28 | 30 | 37227 | 83240 | 34836434 |
Injection site pain | 26 | 17.28 | 5 | 37252 | 39000 | 34880674 |
Memory impairment | 25.98 | 17.28 | 7 | 37250 | 43311 | 34876363 |
Cardiac disorder | 25.81 | 17.28 | 7 | 37250 | 43119 | 34876555 |
Abdominal pain | 25.71 | 17.28 | 277 | 36980 | 163341 | 34756333 |
Myocardial infarction | 25.54 | 17.28 | 57 | 37200 | 121028 | 34798646 |
Somnolence | 25.38 | 17.28 | 50 | 37207 | 111066 | 34808608 |
Adenoviral hepatitis | 24.94 | 17.28 | 12 | 37245 | 532 | 34919142 |
Inappropriate schedule of product administration | 24.93 | 17.28 | 18 | 37239 | 62278 | 34857396 |
Acute myeloid leukaemia | 24.80 | 17.28 | 58 | 37199 | 18212 | 34901462 |
Metastases to chest wall | 24.60 | 17.28 | 9 | 37248 | 198 | 34919476 |
Adenovirus reactivation | 23.83 | 17.28 | 9 | 37248 | 217 | 34919457 |
Metabolic disorder | 23.80 | 17.28 | 26 | 37231 | 4257 | 34915417 |
Second primary malignancy | 23.34 | 17.28 | 35 | 37222 | 7851 | 34911823 |
Erythropenia | 23.19 | 17.28 | 9 | 37248 | 234 | 34919440 |
Tumour lysis syndrome | 22.98 | 17.28 | 54 | 37203 | 17005 | 34902669 |
Chest discomfort | 22.83 | 17.28 | 15 | 37242 | 54515 | 34865159 |
Cardiotoxicity | 22.62 | 17.28 | 29 | 37228 | 5619 | 34914055 |
Renal-limited thrombotic microangiopathy | 22.54 | 17.28 | 7 | 37250 | 91 | 34919583 |
Angioedema | 22.49 | 17.28 | 6 | 37251 | 37368 | 34882306 |
PIK3CA-activated mutation | 22.26 | 17.28 | 7 | 37250 | 95 | 34919579 |
Metastases to peritoneum | 21.65 | 17.28 | 17 | 37240 | 1827 | 34917847 |
Peritoneal lesion | 21.62 | 17.28 | 7 | 37250 | 105 | 34919569 |
Jaundice cholestatic | 21.42 | 17.28 | 26 | 37231 | 4768 | 34914906 |
Palpitations | 21.25 | 17.28 | 8 | 37249 | 39978 | 34879696 |
Sleep disorder | 21.25 | 17.28 | 4 | 37253 | 31684 | 34887990 |
Wrong technique in product usage process | 21.24 | 17.28 | 6 | 37251 | 35980 | 34883694 |
Rhabdomyolysis | 21.01 | 17.28 | 25 | 37232 | 68138 | 34851536 |
Thyroglobulin increased | 21.01 | 17.28 | 5 | 37252 | 21 | 34919653 |
Wheezing | 20.83 | 17.28 | 9 | 37248 | 41393 | 34878281 |
Colitis | 20.36 | 17.28 | 87 | 37170 | 37663 | 34882011 |
Pain in extremity | 20.35 | 17.28 | 68 | 37189 | 126445 | 34793229 |
Influenza | 20.33 | 17.28 | 14 | 37243 | 49652 | 34870022 |
Resorption bone increased | 20.33 | 17.28 | 8 | 37249 | 216 | 34919458 |
Granulocyte-colony stimulating factor level increased | 20.14 | 17.28 | 4 | 37253 | 5 | 34919669 |
Incorrect dose administered | 20.08 | 17.28 | 9 | 37248 | 40506 | 34879168 |
Vascular purpura | 20.03 | 17.28 | 16 | 37241 | 1762 | 34917912 |
Contusion | 19.79 | 17.28 | 7 | 37250 | 36357 | 34883317 |
Peripheral swelling | 19.66 | 17.28 | 32 | 37225 | 76509 | 34843165 |
Metastases to muscle | 19.64 | 17.28 | 8 | 37249 | 237 | 34919437 |
Malaise | 19.56 | 17.28 | 117 | 37140 | 185708 | 34733966 |
Abdominal discomfort | 19.47 | 17.28 | 21 | 37236 | 59814 | 34859860 |
Duodenal stenosis | 19.45 | 17.28 | 8 | 37249 | 243 | 34919431 |
Diffuse large B-cell lymphoma | 19.42 | 17.28 | 31 | 37226 | 7339 | 34912335 |
Pneumonia adenoviral | 19.38 | 17.28 | 9 | 37248 | 368 | 34919306 |
Gastrointestinal obstruction | 19.32 | 17.28 | 12 | 37245 | 885 | 34918789 |
Blood creatine phosphokinase increased | 19.24 | 17.28 | 12 | 37245 | 44845 | 34874829 |
Condition aggravated | 19.20 | 17.28 | 123 | 37134 | 192073 | 34727601 |
Hallucination | 19.18 | 17.28 | 16 | 37241 | 51482 | 34868192 |
Cystoid macular oedema | 19.13 | 17.28 | 11 | 37246 | 704 | 34918970 |
Vascular pseudoaneurysm ruptured | 19.11 | 17.28 | 6 | 37251 | 81 | 34919593 |
Ilium fracture | 18.92 | 17.28 | 7 | 37250 | 159 | 34919515 |
Vision blurred | 18.76 | 17.28 | 13 | 37244 | 45950 | 34873724 |
Balance disorder | 18.68 | 17.28 | 10 | 37247 | 40644 | 34879030 |
Pruritus | 18.54 | 17.28 | 83 | 37174 | 141898 | 34777776 |
Hypophagia | 18.46 | 17.28 | 62 | 37195 | 23960 | 34895714 |
Cardio-respiratory arrest | 18.43 | 17.28 | 19 | 37238 | 55254 | 34864420 |
Peripheral artery occlusion | 18.43 | 17.28 | 15 | 37242 | 1697 | 34917977 |
Toxic erythema of chemotherapy | 18.35 | 17.28 | 6 | 37251 | 93 | 34919581 |
Chronic coronary syndrome | 18.33 | 17.28 | 7 | 37250 | 174 | 34919500 |
Molluscum contagiosum | 18.29 | 17.28 | 8 | 37249 | 284 | 34919390 |
Transitional cell carcinoma recurrent | 17.85 | 17.28 | 4 | 37253 | 12 | 34919662 |
Testicular disorder | 17.85 | 17.28 | 11 | 37246 | 800 | 34918874 |
Tumour necrosis | 17.60 | 17.28 | 13 | 37244 | 1275 | 34918399 |
Portal vein stenosis | 17.54 | 17.28 | 3 | 37254 | 0 | 34919674 |
Retroperitoneal neoplasm metastatic | 17.54 | 17.28 | 3 | 37254 | 0 | 34919674 |
Dizziness | 17.44 | 17.28 | 149 | 37108 | 218372 | 34701302 |
Tumour fistulisation | 17.38 | 17.28 | 4 | 37253 | 14 | 34919660 |
Disseminated intravascular coagulation | 17.38 | 17.28 | 57 | 37200 | 21759 | 34897915 |
Haemoglobin decreased | 17.37 | 17.28 | 201 | 37056 | 120571 | 34799103 |
Gastroenteritis radiation | 17.35 | 17.28 | 8 | 37249 | 322 | 34919352 |
Fistula of small intestine | 17.28 | 17.28 | 9 | 37248 | 473 | 34919201 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Disease progression | 1964.74 | 15.29 | 1450 | 65335 | 182912 | 79494691 |
Thrombocytopenia | 1583.88 | 15.29 | 1492 | 65293 | 263767 | 79413836 |
Thrombotic microangiopathy | 1101.63 | 15.29 | 467 | 66318 | 19702 | 79657901 |
Malignant neoplasm progression | 1081.07 | 15.29 | 901 | 65884 | 135089 | 79542514 |
Neutropenia | 935.83 | 15.29 | 1176 | 65609 | 286534 | 79391069 |
Anaemia | 624.14 | 15.29 | 1236 | 65549 | 443779 | 79233824 |
Myelosuppression | 616.36 | 15.29 | 397 | 66388 | 39899 | 79637704 |
Neoplasm progression | 571.97 | 15.29 | 417 | 66368 | 51265 | 79626338 |
Pancytopenia | 449.96 | 15.29 | 621 | 66164 | 165124 | 79512479 |
Haematotoxicity | 376.49 | 15.29 | 206 | 66579 | 15313 | 79662290 |
Febrile neutropenia | 347.50 | 15.29 | 662 | 66123 | 230337 | 79447266 |
Off label use | 332.80 | 15.29 | 1568 | 65217 | 905647 | 78771956 |
Leukopenia | 331.79 | 15.29 | 447 | 66338 | 116066 | 79561537 |
Pyrexia | 331.32 | 15.29 | 1280 | 65505 | 677429 | 79000174 |
Cholangitis | 308.27 | 15.29 | 169 | 66616 | 12607 | 79664996 |
Metastases to liver | 282.98 | 15.29 | 215 | 66570 | 28099 | 79649504 |
Diffuse large B-cell lymphoma recurrent | 282.50 | 15.29 | 113 | 66672 | 4094 | 79673509 |
Platelet count decreased | 263.64 | 15.29 | 534 | 66251 | 194130 | 79483473 |
Neuropathy peripheral | 255.61 | 15.29 | 439 | 66346 | 140866 | 79536737 |
Cytokine release syndrome | 253.66 | 15.29 | 223 | 66562 | 35775 | 79641828 |
Arthralgia | 248.10 | 15.29 | 85 | 66700 | 571718 | 79105885 |
Therapy partial responder | 247.77 | 15.29 | 164 | 66621 | 17233 | 79660370 |
Neutrophil count decreased | 242.66 | 15.29 | 344 | 66441 | 93615 | 79583988 |
Haemolytic uraemic syndrome | 219.70 | 15.29 | 96 | 66689 | 4353 | 79673250 |
Biliary tract infection | 218.06 | 15.29 | 70 | 66715 | 1318 | 79676285 |
Metastases to lung | 199.53 | 15.29 | 146 | 66639 | 18017 | 79659586 |
General physical health deterioration | 183.84 | 15.29 | 577 | 66208 | 274661 | 79402942 |
Bone marrow failure | 181.55 | 15.29 | 219 | 66566 | 50888 | 79626715 |
Joint swelling | 177.36 | 15.29 | 18 | 66767 | 288628 | 79388975 |
Capillary leak syndrome | 169.17 | 15.29 | 77 | 66708 | 3848 | 79673755 |
Recall phenomenon | 169.07 | 15.29 | 55 | 66730 | 1082 | 79676521 |
Metastases to lymph nodes | 160.24 | 15.29 | 103 | 66682 | 10294 | 79667309 |
Rheumatoid arthritis | 159.62 | 15.29 | 3 | 66782 | 208467 | 79469136 |
Ascites | 157.01 | 15.29 | 250 | 66535 | 75312 | 79602291 |
Hypertransaminasaemia | 156.82 | 15.29 | 107 | 66678 | 11817 | 79665786 |
Neurotoxicity | 152.46 | 15.29 | 161 | 66624 | 32357 | 79645246 |
Pleural effusion | 151.56 | 15.29 | 359 | 66426 | 144903 | 79532700 |
Pneumonitis | 151.45 | 15.29 | 219 | 66566 | 60641 | 79616962 |
Sepsis | 148.06 | 15.29 | 529 | 66256 | 268899 | 79408704 |
Headache | 146.01 | 15.29 | 201 | 66584 | 653571 | 79024032 |
Acute myeloid leukaemia | 143.17 | 15.29 | 152 | 66633 | 30733 | 79646870 |
Product dose omission issue | 143.17 | 15.29 | 19 | 66766 | 247518 | 79430085 |
Diffuse large B-cell lymphoma refractory | 141.37 | 15.29 | 51 | 66734 | 1384 | 79676219 |
Neutropenic sepsis | 139.51 | 15.29 | 141 | 66644 | 26923 | 79650680 |
Fall | 133.64 | 15.29 | 127 | 66658 | 487502 | 79190101 |
Metastases to bone | 132.80 | 15.29 | 131 | 66654 | 24296 | 79653307 |
Interstitial lung disease | 127.01 | 15.29 | 287 | 66498 | 112313 | 79565290 |
Nasopharyngitis | 126.10 | 15.29 | 29 | 66756 | 253852 | 79423751 |
Pulmonary embolism | 124.88 | 15.29 | 371 | 66414 | 171283 | 79506320 |
Myositis | 121.69 | 15.29 | 112 | 66673 | 19056 | 79658547 |
Second primary malignancy | 119.73 | 15.29 | 98 | 66687 | 14252 | 79663351 |
Metastases to peritoneum | 117.10 | 15.29 | 62 | 66723 | 4310 | 79673293 |
Pseudocellulitis | 112.53 | 15.29 | 23 | 66762 | 53 | 79677550 |
Drug hypersensitivity | 112.27 | 15.29 | 55 | 66730 | 298861 | 79378742 |
Musculoskeletal stiffness | 109.86 | 15.29 | 10 | 66775 | 174998 | 79502605 |
Weight increased | 107.30 | 15.29 | 49 | 66736 | 277337 | 79400266 |
Disease recurrence | 105.77 | 15.29 | 156 | 66629 | 43953 | 79633650 |
Mucosal inflammation | 105.30 | 15.29 | 210 | 66575 | 75370 | 79602233 |
Overdose | 104.46 | 15.29 | 15 | 66770 | 184191 | 79493412 |
Blood lactate dehydrogenase increased | 103.39 | 15.29 | 145 | 66640 | 39025 | 79638578 |
Product use in unapproved indication | 101.48 | 15.29 | 447 | 66338 | 249912 | 79427691 |
Cytopenia | 101.06 | 15.29 | 104 | 66681 | 20279 | 79657324 |
Contraindicated product administered | 93.72 | 15.29 | 11 | 66774 | 157527 | 79520076 |
Peripheral ischaemia | 92.67 | 15.29 | 71 | 66714 | 9386 | 79668217 |
Asthma | 92.63 | 15.29 | 5 | 66780 | 135090 | 79542513 |
Peripheral swelling | 91.94 | 15.29 | 56 | 66729 | 269561 | 79408042 |
Bacteraemia | 91.87 | 15.29 | 125 | 66660 | 32699 | 79644904 |
Liver abscess | 88.44 | 15.29 | 58 | 66727 | 5996 | 79671607 |
Abdominal discomfort | 88.42 | 15.29 | 50 | 66735 | 250677 | 79426926 |
Tumour lysis syndrome | 87.31 | 15.29 | 104 | 66681 | 23835 | 79653768 |
Maternal exposure during pregnancy | 82.55 | 15.29 | 9 | 66776 | 136529 | 79541074 |
Insomnia | 82.09 | 15.29 | 52 | 66733 | 245118 | 79432485 |
Metastases to central nervous system | 81.99 | 15.29 | 84 | 66701 | 16291 | 79661312 |
Atypical haemolytic uraemic syndrome | 80.85 | 15.29 | 31 | 66754 | 1001 | 79676602 |
Arthropathy | 80.73 | 15.29 | 24 | 66761 | 177087 | 79500516 |
Pain | 80.17 | 15.29 | 311 | 66474 | 703491 | 78974112 |
Swelling | 79.65 | 15.29 | 41 | 66744 | 216670 | 79460933 |
Microangiopathic haemolytic anaemia | 78.82 | 15.29 | 34 | 66751 | 1493 | 79676110 |
Therapeutic product effect decreased | 76.91 | 15.29 | 21 | 66764 | 163842 | 79513761 |
Systemic lupus erythematosus | 75.81 | 15.29 | 7 | 66778 | 121142 | 79556461 |
Muscle spasms | 75.52 | 15.29 | 26 | 66759 | 174704 | 79502899 |
Feeling abnormal | 75.48 | 15.29 | 20 | 66765 | 159179 | 79518424 |
Sinusitis | 74.85 | 15.29 | 35 | 66750 | 195466 | 79482137 |
Wound | 74.65 | 15.29 | 6 | 66779 | 116173 | 79561430 |
Drug interaction | 74.46 | 15.29 | 147 | 66638 | 415036 | 79262567 |
Embolism | 74.17 | 15.29 | 74 | 66711 | 13908 | 79663695 |
Contusion | 73.82 | 15.29 | 17 | 66768 | 148759 | 79528844 |
Pancreatic carcinoma metastatic | 72.64 | 15.29 | 43 | 66742 | 3710 | 79673893 |
Anxiety | 72.43 | 15.29 | 61 | 66724 | 248451 | 79429152 |
Pulmonary toxicity | 71.57 | 15.29 | 70 | 66715 | 12844 | 79664759 |
Posterior reversible encephalopathy syndrome | 68.92 | 15.29 | 97 | 66688 | 26184 | 79651419 |
White blood cell count decreased | 67.94 | 15.29 | 325 | 66460 | 187963 | 79489640 |
Hyperpyrexia | 66.96 | 15.29 | 49 | 66736 | 6043 | 79671560 |
Vomiting | 66.16 | 15.29 | 849 | 65936 | 664979 | 79012624 |
Skin toxicity | 65.65 | 15.29 | 55 | 66730 | 8259 | 79669344 |
Injection site pain | 64.09 | 15.29 | 15 | 66770 | 129823 | 79547780 |
Asthenia | 62.98 | 15.29 | 680 | 66105 | 511009 | 79166594 |
Memory impairment | 61.27 | 15.29 | 10 | 66775 | 111724 | 79565879 |
Immune-mediated hepatitis | 60.78 | 15.29 | 38 | 66747 | 3618 | 79673985 |
Cardiotoxicity | 59.86 | 15.29 | 62 | 66723 | 12177 | 79665426 |
Abdominal pain | 59.72 | 15.29 | 542 | 66243 | 389027 | 79288576 |
Psoriasis | 59.34 | 15.29 | 4 | 66781 | 89583 | 79588020 |
Biliary obstruction | 59.23 | 15.29 | 41 | 66744 | 4633 | 79672970 |
Bile duct stenosis | 58.02 | 15.29 | 30 | 66755 | 1986 | 79675617 |
Exposure during pregnancy | 57.86 | 15.29 | 8 | 66777 | 101124 | 79576479 |
Colitis | 57.63 | 15.29 | 163 | 66622 | 73144 | 79604459 |
Deep vein thrombosis | 57.62 | 15.29 | 227 | 66558 | 120692 | 79556911 |
Suicide attempt | 57.06 | 15.29 | 3 | 66782 | 82929 | 79594674 |
Depression | 56.35 | 15.29 | 59 | 66726 | 216731 | 79460872 |
Extremity necrosis | 55.45 | 15.29 | 34 | 66751 | 3127 | 79674476 |
Cholangitis infective | 55.42 | 15.29 | 21 | 66764 | 656 | 79676947 |
Device occlusion | 54.27 | 15.29 | 58 | 66727 | 11808 | 79665795 |
Drug resistance | 53.71 | 15.29 | 113 | 66672 | 42100 | 79635503 |
Pancreatic enzyme abnormality | 53.48 | 15.29 | 14 | 66771 | 122 | 79677481 |
Sleep disorder | 53.47 | 15.29 | 5 | 66780 | 85672 | 79591931 |
Injection site erythema | 53.27 | 15.29 | 3 | 66782 | 78194 | 79599409 |
Chills | 52.40 | 15.29 | 269 | 66516 | 159965 | 79517638 |
Suicidal ideation | 51.78 | 15.29 | 3 | 66782 | 76337 | 79601266 |
Pericarditis | 51.53 | 15.29 | 12 | 66773 | 104224 | 79573379 |
Mobility decreased | 51.38 | 15.29 | 19 | 66766 | 122156 | 79555447 |
Wheezing | 51.03 | 15.29 | 17 | 66768 | 116647 | 79560956 |
Arthritis | 49.79 | 15.29 | 17 | 66768 | 114863 | 79562740 |
Palmar-plantar erythrodysaesthesia syndrome | 49.70 | 15.29 | 95 | 66690 | 33039 | 79644564 |
Toxic erythema of chemotherapy | 48.99 | 15.29 | 15 | 66770 | 240 | 79677363 |
Pericardial effusion | 48.94 | 15.29 | 115 | 66670 | 46122 | 79631481 |
Pain in extremity | 48.88 | 15.29 | 150 | 66635 | 364388 | 79313215 |
Decreased appetite | 48.73 | 15.29 | 469 | 66316 | 341949 | 79335654 |
Haemoglobin decreased | 47.67 | 15.29 | 334 | 66451 | 221785 | 79455818 |
Hepatotoxicity | 47.22 | 15.29 | 121 | 66664 | 51231 | 79626372 |
Product use issue | 47.18 | 15.29 | 64 | 66721 | 209758 | 79467845 |
Hepatic failure | 47.04 | 15.29 | 135 | 66650 | 61077 | 79616526 |
Somnolence | 46.89 | 15.29 | 80 | 66705 | 238901 | 79438702 |
Loss of personal independence in daily activities | 46.55 | 15.29 | 14 | 66771 | 102566 | 79575037 |
Nasal congestion | 46.38 | 15.29 | 5 | 66780 | 76547 | 79601056 |
Blood pressure increased | 45.99 | 15.29 | 66 | 66719 | 211294 | 79466309 |
Discomfort | 45.78 | 15.29 | 24 | 66761 | 125593 | 79552010 |
Hepatic enzyme increased | 44.92 | 15.29 | 52 | 66733 | 182558 | 79495045 |
Subacute cutaneous lupus erythematosus | 44.57 | 15.29 | 31 | 66754 | 3530 | 79674073 |
Urticaria | 44.20 | 15.29 | 54 | 66731 | 185147 | 79492456 |
Biliary sepsis | 43.50 | 15.29 | 23 | 66762 | 1594 | 79676009 |
Bronchitis | 43.30 | 15.29 | 28 | 66757 | 130616 | 79546987 |
Dizziness | 43.30 | 15.29 | 261 | 66524 | 526180 | 79151423 |
Osteoarthritis | 43.26 | 15.29 | 10 | 66775 | 87299 | 79590304 |
Cerebral ischaemia | 43.08 | 15.29 | 50 | 66735 | 11145 | 79666458 |
Pancreatic carcinoma | 43.08 | 15.29 | 55 | 66730 | 13522 | 79664081 |
Gait disturbance | 42.06 | 15.29 | 68 | 66717 | 207438 | 79470165 |
Stress | 41.74 | 15.29 | 8 | 66777 | 79604 | 79597999 |
Peripheral sensory neuropathy | 41.68 | 15.29 | 53 | 66732 | 12980 | 79664623 |
Blood cholesterol increased | 40.67 | 15.29 | 10 | 66775 | 83710 | 79593893 |
Injury | 40.18 | 15.29 | 8 | 66777 | 77488 | 79600115 |
Metastasis | 39.45 | 15.29 | 38 | 66747 | 6842 | 79670761 |
Myalgia | 39.38 | 15.29 | 59 | 66726 | 185582 | 79492021 |
Malaise | 38.64 | 15.29 | 246 | 66539 | 489623 | 79187980 |
Lower respiratory tract infection | 38.51 | 15.29 | 31 | 66754 | 129189 | 79548414 |
Hypercalcaemia of malignancy | 38.19 | 15.29 | 14 | 66771 | 398 | 79677205 |
Blister | 37.73 | 15.29 | 27 | 66758 | 119449 | 79558154 |
Erythropenia | 37.58 | 15.29 | 14 | 66771 | 417 | 79677186 |
Renal-limited thrombotic microangiopathy | 37.35 | 15.29 | 11 | 66774 | 153 | 79677450 |
Urosepsis | 37.34 | 15.29 | 74 | 66711 | 26421 | 79651182 |
Pancreatic fistula | 37.33 | 15.29 | 10 | 66775 | 96 | 79677507 |
EGFR gene mutation | 36.57 | 15.29 | 14 | 66771 | 450 | 79677153 |
PIK3CA-activated mutation | 36.38 | 15.29 | 15 | 66770 | 588 | 79677015 |
Dehydration | 36.30 | 15.29 | 342 | 66443 | 247845 | 79429758 |
Influenza | 36.30 | 15.29 | 33 | 66752 | 129573 | 79548030 |
Right ventricular ejection fraction decreased | 36.24 | 15.29 | 9 | 66776 | 62 | 79677541 |
Migraine | 36.13 | 15.29 | 14 | 66771 | 87479 | 79590124 |
Myelodysplastic syndrome | 36.11 | 15.29 | 79 | 66706 | 30222 | 79647381 |
Capillary permeability increased | 36.04 | 15.29 | 8 | 66777 | 31 | 79677572 |
Metastases to pleura | 35.95 | 15.29 | 20 | 66765 | 1534 | 79676069 |
Hospitalisation | 35.85 | 15.29 | 17 | 66768 | 94219 | 79583384 |
Hypoalbuminaemia | 35.62 | 15.29 | 64 | 66721 | 21233 | 79656370 |
Seizure | 35.42 | 15.29 | 65 | 66720 | 188769 | 79488834 |
Dry gangrene | 35.20 | 15.29 | 17 | 66768 | 972 | 79676631 |
Lymphoma | 35.18 | 15.29 | 57 | 66728 | 17403 | 79660200 |
Lymphadenopathy | 34.85 | 15.29 | 111 | 66674 | 53136 | 79624467 |
Injection site reaction | 34.71 | 15.29 | 3 | 66782 | 54782 | 79622821 |
Hepatocellular injury | 33.73 | 15.29 | 102 | 66683 | 47491 | 79630112 |
Rhinorrhoea | 33.41 | 15.29 | 11 | 66774 | 76063 | 79601540 |
Jaundice cholestatic | 33.14 | 15.29 | 44 | 66741 | 11240 | 79666363 |
BRCA2 gene mutation | 33.00 | 15.29 | 9 | 66776 | 93 | 79677510 |
Dermatitis acneiform | 32.53 | 15.29 | 41 | 66744 | 9952 | 79667651 |
Gastrointestinal toxicity | 32.52 | 15.29 | 37 | 66748 | 8072 | 79669531 |
Disseminated intravascular coagulation | 32.48 | 15.29 | 84 | 66701 | 35758 | 79641845 |
Small intestinal obstruction | 32.38 | 15.29 | 71 | 66714 | 27201 | 79650402 |
Retroperitoneal neoplasm metastatic | 31.98 | 15.29 | 7 | 66778 | 25 | 79677578 |
Performance status decreased | 31.77 | 15.29 | 32 | 66753 | 6081 | 79671522 |
Pancreatic carcinoma recurrent | 31.72 | 15.29 | 10 | 66775 | 177 | 79677426 |
Myocardial infarction | 31.41 | 15.29 | 67 | 66718 | 184062 | 79493541 |
Nephropathy toxic | 31.18 | 15.29 | 59 | 66726 | 20360 | 79657243 |
Chronic myelomonocytic leukaemia | 31.17 | 15.29 | 15 | 66770 | 851 | 79676752 |
Polyneuropathy | 31.12 | 15.29 | 65 | 66720 | 24086 | 79653517 |
Bicytopenia | 31.03 | 15.29 | 28 | 66757 | 4642 | 79672961 |
Hypophagia | 31.00 | 15.29 | 96 | 66689 | 45271 | 79632332 |
Cholestasis | 30.86 | 15.29 | 105 | 66680 | 52004 | 79625599 |
Breast cancer metastatic | 30.75 | 15.29 | 37 | 66748 | 8565 | 79669038 |
Jaundice | 30.28 | 15.29 | 106 | 66679 | 53243 | 79624360 |
Inappropriate schedule of product administration | 29.78 | 15.29 | 41 | 66744 | 133587 | 79544016 |
Tremor | 29.76 | 15.29 | 61 | 66724 | 170022 | 79507581 |
Alopecia | 29.71 | 15.29 | 97 | 66688 | 231258 | 79446345 |
Blood bilirubin increased | 29.66 | 15.29 | 122 | 66663 | 66110 | 79611493 |
Carbohydrate antigen 19-9 increased | 29.53 | 15.29 | 12 | 66773 | 453 | 79677150 |
Tumour necrosis | 29.51 | 15.29 | 19 | 66766 | 1903 | 79675700 |
Heart rate decreased | 29.45 | 15.29 | 11 | 66774 | 70305 | 79607298 |
Type 2 diabetes mellitus | 29.40 | 15.29 | 6 | 66779 | 57116 | 79620487 |
Immune effector cell-associated neurotoxicity syndrome | 29.28 | 15.29 | 30 | 66755 | 5818 | 79671785 |
Pneumocystis jirovecii pneumonia | 29.26 | 15.29 | 76 | 66709 | 32432 | 79645171 |
Aggression | 29.22 | 15.29 | 4 | 66781 | 50954 | 79626649 |
Fluid retention | 29.11 | 15.29 | 11 | 66774 | 69798 | 79607805 |
Disturbance in attention | 29.10 | 15.29 | 4 | 66781 | 50797 | 79626806 |
Condition aggravated | 29.02 | 15.29 | 274 | 66511 | 500850 | 79176753 |
Gait inability | 28.69 | 15.29 | 7 | 66778 | 58910 | 79618693 |
Urinary tract obstruction | 28.62 | 15.29 | 27 | 66758 | 4738 | 79672865 |
Wrong technique in product usage process | 28.61 | 15.29 | 13 | 66772 | 73862 | 79603741 |
Angioedema | 28.49 | 15.29 | 14 | 66771 | 76021 | 79601582 |
Nausea | 28.46 | 15.29 | 1023 | 65762 | 956173 | 78721430 |
Breast cancer recurrent | 28.40 | 15.29 | 22 | 66763 | 2955 | 79674648 |
Illness | 28.27 | 15.29 | 3 | 66782 | 46508 | 79631095 |
Folliculitis | 28.12 | 15.29 | 6 | 66779 | 55374 | 79622229 |
Oedema peripheral | 28.09 | 15.29 | 329 | 66456 | 251959 | 79425644 |
Palpitations | 28.06 | 15.29 | 39 | 66746 | 126571 | 79551032 |
Heart rate increased | 27.96 | 15.29 | 36 | 66749 | 120688 | 79556915 |
Infusion related reaction | 27.89 | 15.29 | 99 | 66686 | 230138 | 79447465 |
Balance disorder | 27.88 | 15.29 | 25 | 66760 | 98832 | 79578771 |
Bradycardia | 27.86 | 15.29 | 44 | 66741 | 135513 | 79542090 |
Coma | 27.74 | 15.29 | 26 | 66759 | 100623 | 79576980 |
Diffuse large B-cell lymphoma | 27.73 | 15.29 | 42 | 66743 | 12107 | 79665496 |
Renal salt-wasting syndrome | 27.59 | 15.29 | 13 | 66772 | 703 | 79676900 |
Impaired healing | 27.43 | 15.29 | 20 | 66765 | 87635 | 79589968 |
Postictal state | 27.35 | 15.29 | 18 | 66767 | 1871 | 79675732 |
Systemic infection | 27.07 | 15.29 | 37 | 66748 | 9715 | 79667888 |
Myelitis transverse | 26.86 | 15.29 | 18 | 66767 | 1929 | 79675674 |
Cystoid macular oedema | 26.58 | 15.29 | 18 | 66767 | 1962 | 79675641 |
Electrocardiogram QT prolonged | 26.53 | 15.29 | 22 | 66763 | 90364 | 79587239 |
Muscle necrosis | 26.39 | 15.29 | 16 | 66769 | 1442 | 79676161 |
Dry mouth | 26.37 | 15.29 | 21 | 66764 | 87998 | 79589605 |
Injection site swelling | 26.33 | 15.29 | 4 | 66781 | 47128 | 79630475 |
Coronary artery disease | 26.18 | 15.29 | 11 | 66774 | 65463 | 79612140 |
Hyperbilirubinaemia | 25.96 | 15.29 | 61 | 66724 | 24457 | 79653146 |
Unmasking of previously unidentified disease | 25.96 | 15.29 | 18 | 66767 | 2039 | 79675564 |
Obstruction gastric | 25.96 | 15.29 | 17 | 66768 | 1753 | 79675850 |
Cardiac cirrhosis | 25.91 | 15.29 | 9 | 66776 | 218 | 79677385 |
Metastases to spleen | 25.77 | 15.29 | 12 | 66773 | 632 | 79676971 |
Post thrombotic syndrome | 25.61 | 15.29 | 12 | 66773 | 641 | 79676962 |
Cardio-respiratory arrest | 25.50 | 15.29 | 32 | 66753 | 108478 | 79569125 |
Paraneoplastic pemphigus | 25.05 | 15.29 | 8 | 66777 | 148 | 79677455 |
Carcinoembryonic antigen increased | 24.81 | 15.29 | 18 | 66767 | 2191 | 79675412 |
Enterocolitis infectious | 24.79 | 15.29 | 20 | 66765 | 2849 | 79674754 |
Stress cardiomyopathy | 24.64 | 15.29 | 38 | 66747 | 11128 | 79666475 |
Testicular disorder | 24.58 | 15.29 | 9 | 66776 | 255 | 79677348 |
Cognitive disorder | 24.54 | 15.29 | 14 | 66771 | 69912 | 79607691 |
Aortic thrombosis | 24.18 | 15.29 | 16 | 66769 | 1679 | 79675924 |
Malignant ascites | 23.97 | 15.29 | 14 | 66771 | 1178 | 79676425 |
Chest discomfort | 23.73 | 15.29 | 50 | 66735 | 137994 | 79539609 |
Road traffic accident | 23.73 | 15.29 | 4 | 66781 | 43660 | 79633943 |
Metastatic neoplasm | 23.69 | 15.29 | 25 | 66760 | 5017 | 79672586 |
Gastrointestinal obstruction | 23.53 | 15.29 | 16 | 66769 | 1756 | 79675847 |
Ovarian cancer recurrent | 23.29 | 15.29 | 10 | 66775 | 434 | 79677169 |
Metastases to abdominal wall | 23.22 | 15.29 | 8 | 66777 | 189 | 79677414 |
Chronic coronary syndrome | 23.10 | 15.29 | 7 | 66778 | 108 | 79677495 |
Hepatic infection | 23.01 | 15.29 | 13 | 66772 | 1027 | 79676576 |
Ischaemia | 22.97 | 15.29 | 31 | 66754 | 8044 | 79669559 |
Swollen tongue | 22.91 | 15.29 | 4 | 66781 | 42566 | 79635037 |
Portal vein stenosis | 22.82 | 15.29 | 5 | 66780 | 18 | 79677585 |
Laryngospasm | 22.77 | 15.29 | 22 | 66763 | 3975 | 79673628 |
Metastases to meninges | 22.77 | 15.29 | 21 | 66764 | 3580 | 79674023 |
Hallucination | 22.64 | 15.29 | 23 | 66762 | 85722 | 79591881 |
Gastric perforation | 22.59 | 15.29 | 22 | 66763 | 4015 | 79673588 |
Intestinal perforation | 22.57 | 15.29 | 47 | 66738 | 17379 | 79660224 |
Splenic infarction | 22.46 | 15.29 | 21 | 66764 | 3643 | 79673960 |
Acquired gene mutation | 22.39 | 15.29 | 17 | 66768 | 2216 | 79675387 |
Histiocytic necrotising lymphadenitis | 22.36 | 15.29 | 6 | 66779 | 58 | 79677545 |
Thrombophlebitis | 22.24 | 15.29 | 27 | 66758 | 6308 | 79671295 |
Gastrooesophageal reflux disease | 22.22 | 15.29 | 33 | 66752 | 104213 | 79573390 |
Treatment noncompliance | 22.19 | 15.29 | 8 | 66777 | 52260 | 79625343 |
Tumour associated fever | 22.00 | 15.29 | 12 | 66773 | 885 | 79676718 |
Respiratory failure | 21.97 | 15.29 | 240 | 66545 | 180671 | 79496932 |
Sedation | 21.93 | 15.29 | 8 | 66777 | 51887 | 79625716 |
Lymphangitis | 21.82 | 15.29 | 14 | 66771 | 1394 | 79676209 |
Hypoaesthesia | 21.79 | 15.29 | 77 | 66708 | 179275 | 79498328 |
Acute kidney injury | 21.73 | 15.29 | 579 | 66206 | 518825 | 79158778 |
Scleroderma-like reaction | 21.69 | 15.29 | 7 | 66778 | 134 | 79677469 |
Adenoviral hepatitis | 21.63 | 15.29 | 12 | 66773 | 915 | 79676688 |
Metastases to skin | 21.44 | 15.29 | 15 | 66770 | 1724 | 79675879 |
Red blood cell sedimentation rate increased | 21.33 | 15.29 | 6 | 66779 | 45936 | 79631667 |
Metastases to chest wall | 21.33 | 15.29 | 10 | 66775 | 535 | 79677068 |
Gastrointestinal perforation | 21.29 | 15.29 | 26 | 66759 | 6111 | 79671492 |
Adenovirus reactivation | 21.20 | 15.29 | 9 | 66776 | 380 | 79677223 |
Neutropenic infection | 21.14 | 15.29 | 17 | 66768 | 2410 | 79675193 |
Granulocyte-colony stimulating factor level increased | 21.10 | 15.29 | 4 | 66781 | 5 | 79677598 |
Pruritus | 21.06 | 15.29 | 220 | 66565 | 394428 | 79283175 |
Granulocyte count decreased | 20.91 | 15.29 | 15 | 66770 | 1793 | 79675810 |
Delirium | 20.90 | 15.29 | 24 | 66761 | 84603 | 79593000 |
Generalised oedema | 20.90 | 15.29 | 55 | 66730 | 23654 | 79653949 |
Incorrect dose administered | 20.87 | 15.29 | 20 | 66765 | 76610 | 79600993 |
Flank pain | 20.61 | 15.29 | 49 | 66736 | 19795 | 79657808 |
Thrombotic thrombocytopenic purpura | 20.50 | 15.29 | 26 | 66759 | 6350 | 79671253 |
Pleural mass | 20.47 | 15.29 | 6 | 66779 | 82 | 79677521 |
Livedo reticularis | 20.45 | 15.29 | 21 | 66764 | 4082 | 79673521 |
Vascular pseudoaneurysm ruptured | 20.29 | 15.29 | 7 | 66778 | 166 | 79677437 |
Ilium fracture | 20.28 | 15.29 | 8 | 66777 | 279 | 79677324 |
Metastases to bladder | 20.28 | 15.29 | 8 | 66777 | 279 | 79677324 |
Leukaemic lymphoma | 20.27 | 15.29 | 6 | 66779 | 85 | 79677518 |
Metastases to the mediastinum | 20.25 | 15.29 | 10 | 66775 | 600 | 79677003 |
Thrombocytosis | 20.21 | 15.29 | 30 | 66755 | 8496 | 79669107 |
Discontinued product administered | 20.02 | 15.29 | 6 | 66779 | 89 | 79677514 |
Back pain | 19.94 | 15.29 | 161 | 66624 | 304019 | 79373584 |
Mediastinum neoplasm | 19.89 | 15.29 | 6 | 66779 | 91 | 79677512 |
Septic shock | 19.85 | 15.29 | 173 | 66612 | 122628 | 79554975 |
Vaginal cellulitis | 19.77 | 15.29 | 6 | 66779 | 93 | 79677510 |
Catabolic state | 19.71 | 15.29 | 6 | 66779 | 94 | 79677509 |
Unevaluable event | 19.69 | 15.29 | 11 | 66774 | 55574 | 79622029 |
Drug dependence | 19.54 | 15.29 | 5 | 66780 | 40764 | 79636839 |
Blood creatine phosphokinase increased | 19.50 | 15.29 | 16 | 66769 | 66074 | 79611529 |
Hypersensitivity | 19.47 | 15.29 | 134 | 66651 | 262105 | 79415498 |
Vascular purpura | 19.46 | 15.29 | 18 | 66767 | 3080 | 79674523 |
Hiccups | 19.20 | 15.29 | 32 | 66753 | 9999 | 79667604 |
Bacillus infection | 19.19 | 15.29 | 12 | 66773 | 1143 | 79676460 |
Febrile bone marrow aplasia | 19.12 | 15.29 | 37 | 66748 | 12983 | 79664620 |
Head injury | 19.07 | 15.29 | 4 | 66781 | 37365 | 79640238 |
Epistaxis | 19.03 | 15.29 | 159 | 66626 | 111356 | 79566247 |
Amnesia | 18.94 | 15.29 | 15 | 66770 | 63042 | 79614561 |
Burning sensation | 18.84 | 15.29 | 13 | 66772 | 58619 | 79618984 |
Pneumonia adenoviral | 18.83 | 15.29 | 9 | 66776 | 503 | 79677100 |
Adenosquamous cell lung cancer stage IV | 18.81 | 15.29 | 4 | 66781 | 12 | 79677591 |
Transitional cell carcinoma recurrent | 18.81 | 15.29 | 4 | 66781 | 12 | 79677591 |
Proteinuria | 18.81 | 15.29 | 65 | 66720 | 32437 | 79645166 |
Platelet count increased | 18.77 | 15.29 | 51 | 66734 | 22355 | 79655248 |
Metastases to diaphragm | 18.76 | 15.29 | 5 | 66780 | 47 | 79677556 |
Drug level increased | 18.75 | 15.29 | 5 | 66780 | 39646 | 79637957 |
Product quality issue | 18.68 | 15.29 | 3 | 66782 | 33937 | 79643666 |
Medication error | 18.60 | 15.29 | 18 | 66767 | 68624 | 79608979 |
Gastric neoplasm | 18.51 | 15.29 | 8 | 66777 | 353 | 79677250 |
Erythema | 18.50 | 15.29 | 276 | 66509 | 223014 | 79454589 |
Pneumothorax | 18.49 | 15.29 | 59 | 66726 | 28264 | 79649339 |
Transaminases increased | 18.40 | 15.29 | 89 | 66696 | 51654 | 79625949 |
Hormone receptor positive breast cancer | 18.38 | 15.29 | 8 | 66777 | 359 | 79677244 |
Febrile infection | 18.28 | 15.29 | 18 | 66767 | 3328 | 79674275 |
Pseudosepsis | 18.26 | 15.29 | 3 | 66782 | 0 | 79677603 |
Neoplasm recurrence | 18.23 | 15.29 | 20 | 66765 | 4194 | 79673409 |
Dacryostenosis acquired | 18.18 | 15.29 | 9 | 66776 | 543 | 79677060 |
Respiratory arrest | 18.17 | 15.29 | 13 | 66772 | 57537 | 79620066 |
Blood alkaline phosphatase increased | 18.16 | 15.29 | 103 | 66682 | 63561 | 79614042 |
Cardiac disorder | 18.10 | 15.29 | 17 | 66768 | 65740 | 79611863 |
Haematuria | 18.10 | 15.29 | 109 | 66676 | 68727 | 79608876 |
Influenza like illness | 18.08 | 15.29 | 20 | 66765 | 71687 | 79605916 |
Pain in jaw | 18.06 | 15.29 | 8 | 66777 | 46143 | 79631460 |
Intestinal metastasis | 17.99 | 15.29 | 8 | 66777 | 378 | 79677225 |
Loss of consciousness | 17.90 | 15.29 | 76 | 66709 | 167867 | 79509736 |
Renal vein thrombosis | 17.89 | 15.29 | 9 | 66776 | 562 | 79677041 |
Renal failure | 17.67 | 15.29 | 251 | 66534 | 200717 | 79476886 |
Infusion site thrombosis | 17.62 | 15.29 | 7 | 66778 | 249 | 79677354 |
Speech disorder | 17.59 | 15.29 | 12 | 66773 | 54433 | 79623170 |
Ureteric fistula | 17.54 | 15.29 | 4 | 66781 | 18 | 79677585 |
Lymphadenopathy mediastinal | 17.53 | 15.29 | 20 | 66765 | 4376 | 79673227 |
BRAF gene mutation | 17.51 | 15.29 | 5 | 66780 | 62 | 79677541 |
Gastrointestinal disorder | 17.28 | 15.29 | 49 | 66736 | 122156 | 79555447 |
Duodenal obstruction | 17.26 | 15.29 | 8 | 66777 | 417 | 79677186 |
Splenic marginal zone lymphoma | 17.22 | 15.29 | 5 | 66780 | 66 | 79677537 |
Ovarian cancer metastatic | 17.18 | 15.29 | 9 | 66776 | 612 | 79676991 |
Q fever | 17.18 | 15.29 | 7 | 66778 | 266 | 79677337 |
Emotional distress | 17.17 | 15.29 | 6 | 66779 | 39963 | 79637640 |
Dyskinesia | 17.15 | 15.29 | 8 | 66777 | 44765 | 79632838 |
Basal cell carcinoma | 17.14 | 15.29 | 5 | 66780 | 37370 | 79640233 |
Acute erythroid leukaemia | 16.98 | 15.29 | 7 | 66778 | 274 | 79677329 |
Hydronephrosis | 16.95 | 15.29 | 42 | 66743 | 17412 | 79660191 |
Ureteric compression | 16.94 | 15.29 | 7 | 66778 | 276 | 79677327 |
Thrombophlebitis migrans | 16.87 | 15.29 | 8 | 66777 | 439 | 79677164 |
Oropharyngeal pain | 16.86 | 15.29 | 42 | 66743 | 109311 | 79568292 |
Subdural haematoma | 16.81 | 15.29 | 3 | 66782 | 31431 | 79646172 |
Therapeutic product effect incomplete | 16.77 | 15.29 | 187 | 66598 | 141458 | 79536145 |
Metastases to stomach | 16.73 | 15.29 | 7 | 66778 | 285 | 79677318 |
Tumour thrombosis | 16.66 | 15.29 | 6 | 66779 | 162 | 79677441 |
Blood disorder | 16.66 | 15.29 | 27 | 66758 | 8246 | 79669357 |
Herpes zoster | 16.60 | 15.29 | 33 | 66752 | 93050 | 79584553 |
Dyspepsia | 16.56 | 15.29 | 42 | 66743 | 108645 | 79568958 |
Necrosis | 16.48 | 15.29 | 29 | 66756 | 9464 | 79668139 |
Peripheral artery occlusion | 16.34 | 15.29 | 15 | 66770 | 2542 | 79675061 |
Bone trimming | 16.31 | 15.29 | 4 | 66781 | 26 | 79677577 |
Haemoptysis | 16.24 | 15.29 | 91 | 66694 | 55908 | 79621695 |
Thyroglobulin increased | 16.22 | 15.29 | 5 | 66780 | 82 | 79677521 |
Embolism arterial | 16.21 | 15.29 | 12 | 66773 | 1506 | 79676097 |
Molluscum contagiosum | 16.19 | 15.29 | 8 | 66777 | 481 | 79677122 |
Musculoskeletal pain | 16.02 | 15.29 | 39 | 66746 | 102315 | 79575288 |
Peritoneal disorder | 15.76 | 15.29 | 9 | 66776 | 726 | 79676877 |
Oroticaciduria | 15.72 | 15.29 | 3 | 66782 | 4 | 79677599 |
Tumour fistulisation | 15.69 | 15.29 | 4 | 66781 | 31 | 79677572 |
Heart rate irregular | 15.68 | 15.29 | 4 | 66781 | 32675 | 79644928 |
Recurrent cancer | 15.68 | 15.29 | 15 | 66770 | 2678 | 79674925 |
Haemobilia | 15.61 | 15.29 | 8 | 66777 | 520 | 79677083 |
Lymphoedema | 15.52 | 15.29 | 33 | 66752 | 12380 | 79665223 |
Pancreatic abscess | 15.48 | 15.29 | 5 | 66780 | 96 | 79677507 |
Chronic obstructive pulmonary disease | 15.48 | 15.29 | 30 | 66755 | 85389 | 79592214 |
Incorrect route of product administration | 15.42 | 15.29 | 5 | 66780 | 34924 | 79642679 |
Platelet toxicity | 15.32 | 15.29 | 3 | 66782 | 5 | 79677598 |
Metastases to muscle | 15.32 | 15.29 | 7 | 66778 | 353 | 79677250 |
None
Source | Code | Description |
---|---|---|
ATC | L01BC05 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS ANTIMETABOLITES Pyrimidine analogues |
FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
FDA EPC | N0000175595 | Nucleoside Metabolic Inhibitor |
CHEBI has role | CHEBI:35221 | antimetabolite |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35705 | immunosuppressive agents |
CHEBI has role | CHEBI:36044 | antiviral drugs |
CHEBI has role | CHEBI:74213 | EC 1.17.4.1 inhibitor |
CHEBI has role | CHEBI:132992 | radiosensitizing agents |
CHEBI has role | CHEBI:149553 | anticoronaviral drug |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:47868 | photosensitising agent |
CHEBI has role | CHEBI:50266 | Prodrugs |
CHEBI has role | CHEBI:59517 | DNA synthesis inhibitors |
CHEBI has role | CHEBI:78298 | environmental contaminants |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Non-small cell lung cancer | indication | 254637007 | DOID:3908 |
Malignant tumor of ovary | indication | 363443007 | DOID:2394 |
Adenocarcinoma of pancreas | indication | 700423003 | DOID:4074 |
Metastatic Breast Carcinoma | indication | ||
Ewing's sarcoma | off-label use | 76909002 | DOID:3369 |
Small cell carcinoma of lung | off-label use | 254632001 | DOID:5409 |
Malignant tumor of head and/or neck | off-label use | 255056009 | |
Malignant tumor of testis | off-label use | 363449006 | DOID:2998 |
Malignant tumor of urinary bladder | off-label use | 399326009 | DOID:11054 |
Biliary Tract Malignancy | off-label use | ||
Refractory Osteosarcoma | off-label use | ||
Infectious disease | contraindication | 40733004 | |
Interstitial pneumonia | contraindication | 64667001 | |
Leukopenia | contraindication | 84828003 | DOID:615 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hemolytic uremic syndrome | contraindication | 111407006 | DOID:12554 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Bone marrow depression | contraindication | 307762000 | |
Breastfeeding (mother) | contraindication | 413712001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 10.69 | acidic |
pKa2 | 12.86 | acidic |
pKa3 | 3.97 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Ribonucleoside-diphosphate reductase large subunit | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
Ribonucleoside-diphosphate reductase subunit M2 | Enzyme | INHIBITOR | WOMBAT-PK | CHEMBL | |||||
DNA polymerase (alpha/delta/epsilon) | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
Thymidylate synthase | Enzyme | WOMBAT-PK | |||||||
Deoxycytidine kinase | Kinase | WOMBAT-PK | |||||||
UMP-CMP kinase | Kinase | WOMBAT-PK |
ID | Source |
---|---|
4024031 | VUID |
N0000022036 | NUI |
D01155 | KEGG_DRUG |
122111-03-9 | SECONDARY_CAS_RN |
4020975 | VANDF |
4024031 | VANDF |
C0045093 | UMLSCUI |
CHEBI:175901 | CHEBI |
GEO | PDB_CHEM_ID |
CHEMBL888 | ChEMBL_ID |
DB00441 | DRUGBANK_ID |
CHEMBL1637 | ChEMBL_ID |
60750 | PUBCHEM_CID |
4793 | IUPHAR_LIGAND_ID |
6515 | INN_ID |
B76N6SBZ8R | UNII |
12574 | RXNORM |
130312 | MMSL |
35333 | MMSL |
4777 | MMSL |
d04010 | MMSL |
005472 | NDDF |
005473 | NDDF |
108811008 | SNOMEDCT_US |
386920008 | SNOMEDCT_US |
412187004 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9394 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAVENOUS | ANDA | 24 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9395 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 24 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0181 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0181 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0181 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0182 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0182 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0182 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0183 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0183 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0183 | INJECTION, SOLUTION | 38 mg | INTRAVENOUS | NDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0185 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 38 mg | INTRAVENOUS | ANDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0185 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 38 mg | INTRAVENOUS | ANDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0186 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 38 mg | INTRAVENOUS | ANDA | 27 sections |
Gemcitabine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0186 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 38 mg | INTRAVENOUS | ANDA | 27 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0187 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 38 mg | INTRAVENOUS | ANDA | 27 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-0187 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 38 mg | INTRAVENOUS | ANDA | 27 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-909 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAVENOUS | ANDA | 25 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16714-930 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 25 sections |
GEMCITABINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-092 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAVENOUS | ANDA | 23 sections |
GEMCITABINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-092 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 200 mg | INTRAVENOUS | ANDA | 23 sections |
GEMCITABINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-117 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
GEMCITABINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-117 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 g | INTRAVENOUS | ANDA | 23 sections |
GEMCITABINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-118 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
GEMCITABINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-118 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2 g | INTRAVENOUS | ANDA | 23 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-391 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-391 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-419 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-419 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |
GEMCITABINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16729-423 | INJECTION, SOLUTION | 100 mg | INTRAVENOUS | NDA | 26 sections |