camphor 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	470	76-22-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: camphor alphanon borneo camphor DL-Camphor root bark oil 2-Bornanone 2-Camphanone camphor (synthetic) camphor (natural) camphor, (synthetic) camphor, (+/-)- camphora	A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent. Molecular weight: 152.24 Formula: C10H16O CLOGP: 2.18 LIPINSKI: 0 HAC: 1 HDO: 0 TPSA: 17.07 ALOGS: -2.24 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

camphor
alphanon
borneo camphor
DL-Camphor
root bark oil
2-Bornanone
2-Camphanone
camphor (synthetic)
camphor (natural)
camphor, (synthetic)
camphor, (+/-)-
camphora

A bicyclic monoterpene ketone found widely in plants, especially CINNAMOMUM CAMPHORA. It is used topically as a skin antipruritic and as an anti-infective agent.

Molecular weight: 152.24
Formula: C10H16O
CLOGP: 2.18
LIPINSKI: 0
HAC: 1
HDO: 0
TPSA: 17.07
ALOGS: -2.24
ROTB: 0

Drug dosage:

Dose	Unit	Route
0.15	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	191.79	14.91	44	5475	2359	63481144
Urticaria thermal	51.35	14.91	11	5508	428	63483075
Administration site erythema	40.21	14.91	10	5509	755	63482748
Pigmentation disorder	36.08	14.91	14	5505	4625	63478878
Drug hypersensitivity	30.91	14.91	77	5442	310610	63172893
Nail bed tenderness	30.02	14.91	7	5512	402	63483101
Hypercholesterolaemia	29.45	14.91	20	5499	21314	63462189
Scratch	28.22	14.91	13	5506	6552	63476951
Vitamin B12 deficiency	27.59	14.91	12	5507	5291	63478212
Dizziness postural	23.81	14.91	12	5507	7364	63476139

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	198.03	20.70	45	1969	3536	34951381
Haemolysis	30.77	20.70	13	2001	8081	34946836
Anticholinergic syndrome	25.02	20.70	7	2007	1262	34953655
Erythema multiforme	23.57	20.70	11	2003	8638	34946279
Pruritus	21.36	20.70	33	1981	141948	34812969

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Methaemoglobinaemia	376.47	14.59	86	5684	5471	79733147
Urticaria thermal	53.21	14.59	11	5759	434	79738184
Administration site erythema	49.24	14.59	10	5760	361	79738257
Pigmentation disorder	35.97	14.59	14	5756	5604	79733014
Pruritus	33.31	14.59	82	5688	394566	79344052
Nail bed tenderness	31.21	14.59	7	5763	407	79738211
Cyanosis	29.77	14.59	20	5750	25162	79713456
Scratch	27.49	14.59	13	5757	8350	79730268
Vitamin B12 deficiency	26.11	14.59	12	5758	7229	79731389
Accidental exposure to product by child	24.97	14.59	9	5761	2917	79735701

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C01EB02	CARDIOVASCULAR SYSTEM CARDIAC THERAPY OTHER CARDIAC PREPARATIONS Other cardiac preparations
CHEBI has role	CHEBI:25212	metabolites
CHEBI has role	CHEBI:27311	essential oil component
CHEBI has role	CHEBI:76924	plant metabolites
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Backache	indication	161891005
Sprains and Strains	indication
Arthritic Pain	indication
Gastritis	contraindication	4556007	DOID:4029
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Gastrointestinal ulcer	contraindication	40845000
Body fluid retention	contraindication	43498006
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Vitamin K deficiency	contraindication	52675005	DOID:11249
Nasal polyp	contraindication	52756005

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Acetylcholinesterase	Enzyme		ACES_ELEEL		Ki	4.30		CHEMBL
Transient receptor potential cation channel subfamily A member 1	Ion channel		TRPA1_MOUSE	GATING INHIBITOR	IC50	4.20		IUPHAR

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External reference:

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ID	Source
CAM	PDB_CHEM_ID
001385	NDDF
001993	NDDF
005178	NDDF
006104	NDDF
111136003	SNOMEDCT_US
1298738	RXNORM
2422	IUPHAR_LIGAND_ID
2537	PUBCHEM_CID
4017533	VUID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
AleveX	HUMAN OTC DRUG LABEL	2	0280-0049	SPRAY	5.50 mg	TOPICAL	OTC monograph not final	15 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0049	SPRAY	5.50 mg	TOPICAL	OTC monograph not final	15 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0050	LOTION	5.50 mg	TOPICAL	OTC monograph not final	15 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0050	LOTION	5.50 mg	TOPICAL	OTC monograph not final	15 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0063	LOTION	5.50 mg	TOPICAL	OTC monograph not final	14 sections
AleveX	HUMAN OTC DRUG LABEL	2	0280-0063	LOTION	5.50 mg	TOPICAL	OTC monograph not final	14 sections
Chest Rub	HUMAN OTC DRUG LABEL	3	0363-8480	LOTION	4.80 kg	TOPICAL	OTC monograph final	15 sections
Large Pain Relieving	HUMAN OTC DRUG LABEL	3	0363-9904	PATCH	3.10 g	TOPICAL	OTC monograph not final	13 sections
Large Pain Relieving	HUMAN OTC DRUG LABEL	3	0363-9904	PATCH	3.10 g	TOPICAL	OTC monograph not final	13 sections
Major Camphor and Phenol	HUMAN OTC DRUG LABEL	2	00904-7851	LIQUID	10.80 g	TOPICAL	OTC monograph final	12 sections

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