ibuprofen Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 1407 15687-27-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ibuprofen lysine
  • ibuprofen lysinate
  • ibuprofen lysine salt
  • soluphene
  • solufenum
  • neoprofen
  • ibuprofen
  • ibuprofen sodium
A nonsteroidal anti-inflammatory agent with analgesic properties used in the treatment of RHEUMATISM and ARTHRITIS.
  • Molecular weight: 206.29
  • Formula: C13H18O2
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.48
  • ROTB: 4

Drug dosage:

DoseUnitRoute
30 mg P
1.20 g O
1.20 g P
1.20 g R

Approvals:

DateAgencyCompanyOrphan
Jan. 19, 2018 PMDA Senju Pharmaceutical Co., Ltd.
Sept. 19, 1974 FDA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 6589.34 26.73 2441 25623 65959 4544969
Acute kidney injury 4910.97 26.73 1992 26072 68439 4542489
Completed suicide 4365.69 26.73 1596 26468 40849 4570079
Toxicity to various agents 4209.26 26.73 1798 26266 70242 4540686
Intentional overdose 3289.70 26.73 1093 26971 20673 4590255
Angioedema 3266.42 26.73 1062 27002 18703 4592225
Overdose 2938.73 26.73 1208 26856 42351 4568577
Vomiting 2356.83 26.73 1436 26628 118263 4492665
Suicide attempt 2211.95 26.73 805 27259 20037 4590891
Gastrointestinal haemorrhage 2045.26 26.73 844 27220 29691 4581237
Urticaria 1781.45 26.73 827 27237 38746 4572182
Haematemesis 1745.40 26.73 548 27516 8495 4602433
Nausea 1476.31 26.73 1263 26801 176070 4434858
Melaena 1467.81 26.73 492 27572 9466 4601462
Gastric ulcer 1311.09 26.73 402 27662 5721 4605207
Tubulointerstitial nephritis 1243.60 26.73 386 27678 5733 4605195
Abdominal pain upper 1198.70 26.73 608 27456 34507 4576421
Metabolic acidosis 1161.23 26.73 438 27626 12002 4598926
Drug interaction 1145.83 26.73 728 27336 63780 4547148
Upper gastrointestinal haemorrhage 1013.33 26.73 323 27741 5250 4605678
Hypotension 997.80 26.73 679 27385 66721 4544207
Gastritis 967.04 26.73 343 27721 7843 4603085
Stevens-Johnson syndrome 956.49 26.73 345 27719 8294 4602634
Abdominal pain 929.47 26.73 622 27442 59402 4551526
Toxic epidermal necrolysis 927.88 26.73 310 27754 5882 4605046
Pruritus 920.14 26.73 665 27399 71907 4539021
Rash 884.95 26.73 766 27298 107622 4503306
Anaphylactic reaction 833.78 26.73 384 27680 17526 4593402
Coma 819.86 26.73 377 27687 17142 4593786
Dyspnoea 800.74 26.73 809 27255 138176 4472752
Dizziness 782.87 26.73 690 27374 99181 4511747
Somnolence 781.94 26.73 496 27568 43164 4567764
Drug abuse 781.88 26.73 424 27640 27523 4583405
Headache 770.69 26.73 748 27316 121625 4489303
Anaemia 753.52 26.73 587 27477 70973 4539955
Aspirin-exacerbated respiratory disease 725.87 26.73 143 27921 206 4610722
Duodenal ulcer 722.99 26.73 218 27846 2912 4608016
Drug ineffective 701.75 26.73 868 27196 185193 4425735
Gastric haemorrhage 699.32 26.73 229 27835 4065 4606863
Tachycardia 693.70 26.73 407 27657 30738 4580190
Hypersensitivity 686.52 26.73 436 27628 37985 4572943
Intentional product misuse 670.37 26.73 334 27730 18159 4592769
Condition aggravated 655.34 26.73 497 27567 57674 4553254
Renal failure 637.71 26.73 428 27636 40941 4569987
Cardiac arrest 620.10 26.73 391 27673 33616 4577312
Pyrexia 609.11 26.73 620 27444 106524 4504404
Haematochezia 603.01 26.73 265 27799 10799 4600129
Lip oedema 600.11 26.73 163 27901 1453 4609475
Renal tubular necrosis 589.19 26.73 198 27866 3820 4607108
Hypothermia 578.38 26.73 199 27865 4135 4606793
Drug-induced liver injury 571.45 26.73 237 27827 8354 4602574
Lip swelling 552.02 26.73 228 27836 7951 4602977
Off label use 550.40 26.73 642 27422 128471 4482457
Erythema 545.52 26.73 391 27673 41549 4569379
Asthma 537.29 26.73 282 27782 17092 4593836
Acute hepatic failure 533.69 26.73 201 27863 5461 4605467
Blood creatinine increased 527.37 26.73 324 27740 26576 4584352
Poisoning 519.63 26.73 200 27864 5774 4605154
Abdominal discomfort 518.63 26.73 327 27737 28081 4582847
Cardio-respiratory arrest 516.06 26.73 287 27777 19535 4591393
Bronchopulmonary dysplasia 492.16 26.73 104 27960 254 4610674
Face oedema 459.91 26.73 189 27875 6501 4604427
Respiratory arrest 458.57 26.73 233 27831 13187 4597741
Pharyngitis 446.63 26.73 157 27907 3482 4607446
Meningitis aseptic 441.64 26.73 123 27941 1213 4609715
Faeces discoloured 439.69 26.73 170 27894 4967 4605961
Pain 429.17 26.73 482 27582 92388 4518540
Product use in unapproved indication 421.76 26.73 275 27789 24998 4585930
Gastritis erosive 415.86 26.73 128 27936 1837 4609091
Eyelid oedema 402.70 26.73 151 27913 4048 4606880
Hyperkalaemia 397.66 26.73 224 27840 15613 4595315
Duodenal ulcer perforation 394.53 26.73 98 27966 588 4610340
Alanine aminotransferase increased 390.52 26.73 274 27790 28099 4582829
Haemoglobin decreased 389.04 26.73 306 27758 37351 4573577
Jaundice 387.02 26.73 203 27861 12271 4598657
Deafness transitory 382.22 26.73 80 27984 183 4610745
Duodenal ulcer haemorrhage 379.86 26.73 108 27956 1155 4609773
Acute generalised exanthematous pustulosis 372.87 26.73 131 27933 2899 4608029
Gastrointestinal pain 368.57 26.73 114 27950 1664 4609264
Weight decreased 367.95 26.73 347 27717 54117 4556811
Swelling face 364.74 26.73 207 27857 14633 4596295
Decreased appetite 359.54 26.73 348 27716 56049 4554879
Gastric ulcer haemorrhage 357.17 26.73 114 27950 1854 4609074
Drug reaction with eosinophilia and systemic symptoms 355.93 26.73 188 27876 11525 4599403
Rectal haemorrhage 355.74 26.73 191 27873 12105 4598823
Necrotising colitis 348.82 26.73 87 27977 532 4610396
Renal impairment 344.70 26.73 243 27821 25095 4585833
Diarrhoea 343.69 26.73 553 27511 149632 4461296
Product prescribing error 340.00 26.73 156 27908 7030 4603898
Ear infection 330.46 26.73 137 27927 4816 4606112
Medication error 322.07 26.73 189 27875 14227 4596701
Rash maculo-papular 311.57 26.73 155 27909 8374 4602554
Hypertension 307.89 26.73 305 27759 50493 4560435
Asthenia 306.92 26.73 392 27672 85771 4525157
Product use issue 305.97 26.73 225 27839 24811 4586117
Dehydration 301.97 26.73 278 27786 42012 4568916
Erosive oesophagitis 299.66 26.73 78 27986 579 4610349
Loss of consciousness 299.37 26.73 257 27807 35425 4575503
Depressed level of consciousness 297.91 26.73 183 27881 14971 4595957
Agitation 296.89 26.73 218 27846 23982 4586946
Enthesopathy 295.34 26.73 66 27998 228 4610700
Wheezing 288.45 26.73 161 27903 11013 4599915
Agranulocytosis 287.63 26.73 141 27923 7376 4603552
Malaise 285.25 26.73 387 27677 89770 4521158
Hypophagia 280.62 26.73 140 27924 7608 4603320
Anuria 277.82 26.73 114 27950 3901 4607027
Dyspepsia 275.80 26.73 178 27886 15876 4595052
Gastrointestinal disorder 273.26 26.73 177 27887 15884 4595044
Syncope 268.93 26.73 235 27829 33160 4577768
Haematuria 266.14 26.73 161 27903 12809 4598119
Accidental overdose 265.52 26.73 143 27921 9112 4601816
Peptic ulcer 265.41 26.73 81 27983 1127 4609801
Gastric ulcer perforation 264.40 26.73 66 27998 405 4610523
Kounis syndrome 263.70 26.73 73 27991 702 4610226
Intentional self-injury 260.30 26.73 131 27933 7252 4603676
Dysphagia 256.03 26.73 204 27860 25327 4585601
Duodenitis 254.24 26.73 79 27985 1171 4609757
Erythema multiforme 252.29 26.73 108 27956 4115 4606813
Death 251.76 26.73 568 27496 197595 4413333
Hepatitis 251.70 26.73 152 27912 12053 4598875
Abortion spontaneous 250.31 26.73 160 27904 14032 4596896
General physical health deterioration 246.87 26.73 210 27854 28568 4582360
Poisoning deliberate 245.07 26.73 89 27975 2173 4608755
Aspartate aminotransferase increased 243.12 26.73 196 27868 24742 4586186
Therapeutic product cross-reactivity 242.80 26.73 69 27995 736 4610192
Hepatitis acute 241.77 26.73 95 27969 2897 4608031
Self-medication 238.58 26.73 77 27987 1299 4609629
Confusional state 237.99 26.73 261 27803 48573 4562355
Nasal disorder 236.46 26.73 63 28001 517 4610411
Haemorrhage 234.67 26.73 194 27870 25368 4585560
Blood urea increased 233.82 26.73 129 27935 8621 4602307
Acute respiratory distress syndrome 232.19 26.73 122 27942 7391 4603537
Hepatitis cholestatic 231.74 26.73 89 27975 2549 4608379
Hepatic failure 231.29 26.73 148 27916 13001 4597927
Renal papillary necrosis 231.13 26.73 46 28018 72 4610856
Shoulder arthroplasty 229.48 26.73 60 28004 454 4610474
Fixed eruption 228.07 26.73 59 28005 426 4610502
Hyperhidrosis 227.81 26.73 204 27860 29713 4581215
Renal tubular acidosis 222.60 26.73 64 28000 714 4610214
Conjunctivitis 221.81 26.73 100 27964 4320 4606608
Vanishing bile duct syndrome 221.24 26.73 55 28009 331 4610597
Pancreatitis acute 218.87 26.73 123 27941 8520 4602408
Lactic acidosis 218.82 26.73 138 27926 11818 4599110
Contraindicated product administered 216.31 26.73 103 27961 5048 4605880
Tongue oedema 215.94 26.73 74 27990 1515 4609413
Eye swelling 213.38 26.73 111 27953 6586 4604342
Ulcer 212.25 26.73 89 27975 3218 4607710
Lethargy 210.67 26.73 155 27909 17086 4593842
International normalised ratio increased 210.46 26.73 154 27910 16834 4594094
Iron deficiency anaemia 209.07 26.73 89 27975 3343 4607585
Rhabdomyolysis 208.38 26.73 162 27902 19396 4591532
Oesophagitis 206.76 26.73 93 27971 3995 4606933
Hypokalaemia 201.19 26.73 156 27908 18604 4592324
C-reactive protein abnormal 200.74 26.73 64 28000 1036 4609892
Exposure during pregnancy 199.64 26.73 198 27866 32773 4578155
Cholestasis 198.62 26.73 112 27952 7808 4603120
Drug eruption 197.74 26.73 105 27959 6498 4604430
Intestinal diaphragm disease 194.40 26.73 40 28024 81 4610847
Tenosynovitis 193.82 26.73 59 28005 813 4610115
Seizure 193.62 26.73 238 27826 49999 4560929
Anaphylactic shock 191.34 26.73 109 27955 7748 4603180
Bronchospasm 190.38 26.73 97 27967 5509 4605419
Incorrect dose administered 190.26 26.73 153 27911 19232 4591696
Coagulopathy 189.95 26.73 100 27964 6080 4604848
Oedema peripheral 186.75 26.73 214 27850 41758 4569170
Cough 185.28 26.73 245 27819 55342 4555586
Musculoskeletal stiffness 185.11 26.73 149 27915 18753 4592175
Coma scale abnormal 181.95 26.73 65 27999 1511 4609417
Circulatory collapse 181.56 26.73 105 27959 7680 4603248
Oedema 179.79 26.73 146 27918 18605 4592323
Synovitis 179.10 26.73 81 27983 3524 4607404
Product administration error 178.11 26.73 106 27958 8178 4602750
Liver injury 174.37 26.73 88 27976 4897 4606031
Drug intolerance 172.89 26.73 152 27912 21594 4589334
Hepatocellular injury 172.23 26.73 102 27962 7798 4603130
Tachypnoea 166.84 26.73 85 27979 4826 4606102
Transaminases increased 166.13 26.73 107 27957 9499 4601429
Periorbital oedema 166.09 26.73 64 28000 1849 4609079
Acidosis 164.38 26.73 75 27989 3331 4607597
Shock 163.35 26.73 103 27961 8813 4602115
Oesophageal ulcer 162.95 26.73 59 28005 1427 4609501
Labelled drug-drug interaction medication error 162.73 26.73 73 27991 3115 4607813
Eosinophilia 162.23 26.73 94 27970 6899 4604029
Leukocytosis 159.75 26.73 96 27968 7538 4603390
Deafness 159.11 26.73 84 27980 5135 4605793
Thrombocytopenia 157.09 26.73 209 27855 47464 4563464
Tongue disorder 156.05 26.73 60 28004 1723 4609205
Inflammation 155.74 26.73 105 27959 10066 4600862
Electrocardiogram QT prolonged 154.93 26.73 123 27941 15172 4595756
Sopor 154.79 26.73 89 27975 6437 4604491
Respiratory failure 154.45 26.73 166 27898 30160 4580768
Loss of personal independence in daily activities 154.44 26.73 96 27968 8009 4602919
Heart rate increased 154.23 26.73 133 27931 18409 4592519
Fatigue 153.83 26.73 389 27675 145177 4465751
Hypertensive emergency 153.71 26.73 43 28021 431 4610497
Laryngeal oedema 152.86 26.73 64 28000 2304 4608624
Eye disorder 151.32 26.73 81 27983 5093 4605835
Chest discomfort 150.95 26.73 145 27919 23065 4587863
Gastric perforation 150.60 26.73 48 28016 776 4610152
Nephropathy toxic 150.23 26.73 75 27989 4077 4606851
Abdominal pain lower 150.07 26.73 76 27988 4260 4606668
Extra dose administered 150.02 26.73 62 28002 2159 4608769
Swelling 149.96 26.73 148 27916 24334 4586594
Respiratory distress 149.61 26.73 106 27958 11010 4599918
Gastritis haemorrhagic 149.13 26.73 44 28020 541 4610387
Arthralgia 147.53 26.73 272 27792 81722 4529206
Foetal exposure during pregnancy 145.52 26.73 142 27922 23027 4587901
Proteinuria 145.49 26.73 86 27978 6550 4604378
Swollen tongue 145.25 26.73 95 27969 8655 4602273
Palatal oedema 144.20 26.73 41 28023 438 4610490
Gastrooesophageal reflux disease 142.84 26.73 116 27948 14777 4596151
C-reactive protein increased 140.52 26.73 108 27956 12704 4598224
Oliguria 140.08 26.73 63 28001 2704 4608224
Chest pain 139.75 26.73 204 27860 50496 4560432
Cellulitis 139.11 26.73 120 27944 16612 4594316
Ductus arteriosus premature closure 138.71 26.73 32 28032 132 4610796
Sepsis 136.82 26.73 185 27879 42654 4568274
Insomnia 136.06 26.73 190 27874 45155 4565773
Flank pain 135.33 26.73 61 28003 2632 4608296
Blister 135.02 26.73 101 27963 11408 4599520
Sinus tachycardia 134.60 26.73 80 27984 6154 4604774
Apnoea 134.23 26.73 64 28000 3144 4607784
Gastrointestinal ulcer 133.62 26.73 43 28021 718 4610210
Lower gastrointestinal haemorrhage 133.43 26.73 58 28006 2293 4608635
Rash macular 132.82 26.73 77 27987 5655 4605273
Foot operation 132.65 26.73 45 28019 892 4610036
Rhinitis 132.57 26.73 55 28009 1934 4608994
Palpitations 130.02 26.73 138 27926 24708 4586220
Milk-alkali syndrome 128.09 26.73 32 28032 197 4610731
Intestinal perforation 124.49 26.73 65 27999 3883 4607045
Blood pressure decreased 124.34 26.73 116 27948 17784 4593144
Mental status changes 124.21 26.73 99 27965 12277 4598651
Bezoar 124.11 26.73 35 28029 362 4610566
Dermatitis bullous 123.93 26.73 59 28005 2888 4608040
Shock haemorrhagic 122.31 26.73 58 28006 2814 4608114
Multiple organ dysfunction syndrome 121.61 26.73 117 27947 18639 4592289
Back pain 121.56 26.73 191 27873 50408 4560520
Septic shock 121.00 26.73 111 27953 16655 4594273
Liver function test abnormal 119.36 26.73 104 27960 14588 4596340
Generalised tonic-clonic seizure 119.21 26.73 89 27975 10021 4600907
Product quality issue 118.44 26.73 119 27945 19980 4590948
Peritonitis 118.13 26.73 71 27993 5574 4605354
Polyuria 116.83 26.73 55 28009 2625 4608303
Gastric disorder 115.43 26.73 71 27993 5811 4605117
Brain oedema 114.92 26.73 66 27998 4761 4606167
Chromaturia 114.23 26.73 70 27994 5691 4605237
Drug level increased 113.59 26.73 72 27992 6214 4604714
Ataxia 113.48 26.73 68 27996 5309 4605619
Myalgia 112.67 26.73 167 27897 41881 4569047
Peritonsillar abscess 112.49 26.73 30 28034 247 4610681
Bradycardia 112.18 26.73 122 27942 22447 4588481
Blood loss anaemia 112.01 26.73 50 28014 2108 4608820
Pneumonia 111.82 26.73 278 27786 102537 4508391
Feeding disorder 110.94 26.73 52 28012 2457 4608471
Therapeutic product effect incomplete 110.91 26.73 107 27957 17101 4593827
Haemodialysis 108.87 26.73 64 28000 4823 4606105
Hypercalcaemia 108.26 26.73 64 28000 4874 4606054
Suicidal ideation 107.85 26.73 117 27947 21466 4589462
Hiatus hernia 107.52 26.73 56 28008 3328 4607600
Hepatic necrosis 107.52 26.73 48 28016 2024 4608904
Mydriasis 107.12 26.73 58 28006 3730 4607198
Tinnitus 106.79 26.73 80 27984 9053 4601875
Obstruction gastric 105.07 26.73 31 28033 381 4610547
Erosive duodenitis 105.00 26.73 31 28033 382 4610546
Necrotising fasciitis 104.72 26.73 41 28023 1237 4609691
Purpura 104.29 26.73 57 28007 3735 4607193
Drug ineffective for unapproved indication 103.61 26.73 66 27998 5745 4605183
Haematocrit decreased 103.52 26.73 78 27986 8904 4602024
Lymphadenopathy 101.87 26.73 82 27982 10310 4600618
Post procedural haemorrhage 100.93 26.73 52 28012 3021 4607907
Pain in extremity 100.47 26.73 200 27864 63539 4547389
Tendonitis 99.95 26.73 56 28008 3852 4607076
Rash erythematous 98.96 26.73 81 27983 10428 4600500
Electrocardiogram QRS complex prolonged 98.77 26.73 45 28019 1991 4608937
Miosis 98.09 26.73 50 28014 2840 4608088
Drug dependence 97.37 26.73 68 27996 6899 4604029
Hypoaldosteronism 96.92 26.73 22 28042 83 4610845
Toxic skin eruption 96.63 26.73 57 28007 4323 4606605
Hyponatraemia 96.51 26.73 118 27946 24612 4586316
Throat tightness 94.98 26.73 65 27999 6381 4604547
Hypoxia 94.93 26.73 87 27977 13034 4597894
White blood cell count increased 94.77 26.73 93 27971 15174 4595754
Pharyngeal oedema 94.54 26.73 61 28003 5428 4605500
Intraventricular haemorrhage 94.51 26.73 37 28027 1116 4609812
Pallor 94.37 26.73 69 27995 7523 4603405
Unresponsive to stimuli 93.37 26.73 77 27987 10016 4600912
Muscular weakness 92.96 26.73 120 27944 26430 4584498
Alanine aminotransferase abnormal 92.80 26.73 31 28033 585 4610343
Streptococcal infection 91.22 26.73 40 28024 1615 4609313
Conjunctival hyperaemia 91.16 26.73 37 28027 1229 4609699
Musculoskeletal disorder 90.64 26.73 52 28012 3743 4607185
Gastrointestinal sounds abnormal 90.50 26.73 35 28029 1021 4609907
Pulseless electrical activity 89.95 26.73 43 28021 2124 4608804
Ulcer haemorrhage 89.11 26.73 35 28029 1065 4609863
Feeling hot 88.91 26.73 76 27988 10385 4600543
Dermo-hypodermitis 88.82 26.73 22 28042 130 4610798
Macrocephaly 88.75 26.73 21 28043 99 4610829
Acute myocardial infarction 87.74 26.73 87 27977 14372 4596556
Prothrombin time prolonged 86.64 26.73 49 28015 3432 4607496
Fall 85.81 26.73 212 27852 77834 4533094
Blood lactate dehydrogenase increased 85.35 26.73 65 27999 7538 4603390
Chills 85.20 26.73 120 27944 28719 4582209
Paraesthesia 84.86 26.73 133 27931 35000 4575928
Mast cell activation syndrome 84.57 26.73 18 28046 46 4610882
Hepatotoxicity 84.57 26.73 67 27997 8232 4602696
Ureteric obstruction 84.33 26.73 28 28036 518 4610410
Large intestinal ulcer 84.27 26.73 32 28032 887 4610041
Arthropathy 83.42 26.73 74 27990 10624 4600304
Blood pressure increased 83.23 26.73 120 27944 29340 4581588
Blood alkaline phosphatase increased 82.91 26.73 79 27985 12428 4598500
Adverse reaction 82.85 26.73 43 28021 2536 4608392
Dysarthria 81.95 26.73 78 27986 12254 4598674
Haemoptysis 81.78 26.73 68 27996 8946 4601982
Thrombotic thrombocytopenic purpura 80.93 26.73 37 28027 1650 4609278
Hypertensive crisis 80.80 26.73 51 28013 4368 4606560
Jejunal ulcer perforation 80.66 26.73 15 28049 12 4610916
Blood bilirubin increased 80.26 26.73 78 27986 12574 4598354
Pulmonary oedema 79.72 26.73 84 27980 14902 4596026
Aggression 79.51 26.73 81 27983 13818 4597110
Arrhythmia 78.99 26.73 80 27984 13552 4597376
Respiratory depression 78.79 26.73 53 28011 5057 4605871
Peripheral swelling 78.75 26.73 111 27953 26581 4584347
Hepatic enzyme increased 78.69 26.73 91 27973 17900 4593028
Deep vein thrombosis 78.17 26.73 108 27956 25386 4585542
Jejunal ulcer 78.07 26.73 18 28046 74 4610854
Dry mouth 77.96 26.73 78 27986 13023 4597905
Mallory-Weiss syndrome 77.86 26.73 27 28037 573 4610355
Chronic kidney disease 77.81 26.73 71 27993 10574 4600354
Haemodynamic instability 77.62 26.73 42 28022 2697 4608231
Gamma-glutamyltransferase increased 76.34 26.73 72 27992 11182 4599746
Neutrophilia 76.26 26.73 32 28032 1158 4609770
Pyloric stenosis 76.11 26.73 24 28040 374 4610554
Analgesic drug level increased 75.88 26.73 25 28039 451 4610477
Psoriatic arthropathy 75.67 26.73 57 28007 6501 4604427
Depression 75.44 26.73 150 27914 47583 4563345
Brain injury 75.43 26.73 38 28026 2105 4608823
Skin exfoliation 74.52 26.73 70 27994 10817 4600111
Disturbance in attention 74.29 26.73 69 27995 10512 4600416
Haematoma 74.17 26.73 67 27997 9849 4601079
Rhinorrhoea 74.07 26.73 73 27991 11969 4598959
Petechiae 73.46 26.73 46 28018 3885 4607043
Paraesthesia oral 73.45 26.73 43 28021 3215 4607713
Brain death 73.38 26.73 31 28033 1141 4609787
Haemolytic anaemia 73.35 26.73 47 28017 4131 4606797
Alcohol use 73.17 26.73 33 28031 1425 4609503
Dysphonia 72.95 26.73 68 27996 10406 4600522
Allergy test positive 72.95 26.73 17 28047 74 4610854
Presyncope 72.63 26.73 57 28007 6907 4604021
Liver disorder 72.51 26.73 75 27989 13023 4597905
Duodenal stenosis 72.35 26.73 20 28044 191 4610737
Abdominal distension 72.07 26.73 87 27977 17902 4593026
Rash pruritic 71.86 26.73 73 27991 12410 4598518
Dactylitis 71.72 26.73 19 28045 152 4610776
Cardiogenic shock 71.52 26.73 51 28013 5347 4605581
Oesophageal stenosis 71.19 26.73 28 28036 855 4610073
Blood bicarbonate decreased 70.89 26.73 29 28035 983 4609945
Tropical infectious disease 70.61 26.73 12 28052 1 4610927
Pharyngeal abscess 70.04 26.73 19 28045 168 4610760
Glomerular filtration rate decreased 70.02 26.73 42 28022 3284 4607644
Joint swelling 69.35 26.73 99 27965 23979 4586949
Colitis 68.99 26.73 66 27998 10433 4600495
Tonsillitis 68.96 26.73 32 28032 1477 4609451
Functional gastrointestinal disorder 68.48 26.73 27 28037 830 4610098
Discomfort 68.20 26.73 59 28005 8191 4602737
Varicella 67.61 26.73 27 28037 859 4610069
Renal disorder 67.37 26.73 62 28002 9334 4601594
Constipation 67.25 26.73 133 27931 42021 4568907
Urine output decreased 67.04 26.73 40 28024 3097 4607831
Pleural effusion 66.89 26.73 98 27966 24300 4586628
Disorientation 66.56 26.73 70 27994 12389 4598539
Ductus arteriosus stenosis foetal 66.37 26.73 18 28046 159 4610769
Infection 66.26 26.73 121 27943 36021 4574907
Alcohol poisoning 66.26 26.73 27 28037 906 4610022
Tremor 65.98 26.73 121 27943 36138 4574790
Substance abuse 65.54 26.73 32 28032 1656 4609272
Febrile convulsion 65.51 26.73 21 28043 346 4610582
Superinfection 65.08 26.73 24 28040 612 4610316
Mycoplasma infection 64.64 26.73 18 28046 177 4610751
Epistaxis 64.43 26.73 86 27978 19557 4591371
Anxiety 64.32 26.73 141 27923 47870 4563058
Hyperlactacidaemia 63.87 26.73 26 28038 870 4610058
Poor quality product administered 63.72 26.73 31 28033 1592 4609336
Gastroenteritis 63.47 26.73 48 28016 5507 4605421
Reaction to excipient 63.37 26.73 23 28041 560 4610368
Dermatitis exfoliative 63.15 26.73 38 28026 2988 4607940
Hepatic function abnormal 63.09 26.73 73 27991 14363 4596565
Dysuria 63.03 26.73 56 28008 8054 4602874
Maternal exposure during pregnancy 62.56 26.73 79 27985 17014 4593914
Haemorrhage intracranial 62.40 26.73 54 28010 7500 4603428
Respiratory disorder 62.37 26.73 55 28009 7833 4603095
Wrong product administered 62.25 26.73 39 28025 3296 4607632
Blood sodium decreased 62.20 26.73 48 28016 5674 4605254
Rash papular 62.09 26.73 44 28020 4567 4606361
Anal haemorrhage 61.38 26.73 23 28041 614 4610314
Small intestinal haemorrhage 61.26 26.73 24 28040 725 4610203
Peptic ulcer perforation 60.80 26.73 15 28049 87 4610841
Oral mucosa erosion 58.94 26.73 21 28043 484 4610444
Arthritis 58.72 26.73 71 27993 14629 4596299
Blood lactic acid increased 58.45 26.73 31 28033 1911 4609017
Toxic shock syndrome streptococcal 58.37 26.73 13 28051 44 4610884
Mucous stools 58.13 26.73 22 28042 604 4610324
Macrophages increased 58.09 26.73 12 28052 25 4610903
Cold sweat 57.86 26.73 40 28024 3991 4606937
Occult blood positive 57.51 26.73 26 28038 1129 4609799
Dialysis 57.46 26.73 43 28021 4856 4606072
Helicobacter infection 57.30 26.73 26 28038 1139 4609789
Oropharyngeal pain 57.07 26.73 76 27988 17243 4593685
Mouth ulceration 57.05 26.73 47 28017 6103 4604825
Influenza like illness 57.00 26.73 80 27984 19073 4591855
Localised oedema 56.59 26.73 28 28036 1492 4609436
Hyperventilation 56.14 26.73 30 28034 1878 4609050
Inappropriate antidiuretic hormone secretion 56.04 26.73 41 28023 4473 4606455
Hyperbilirubinaemia 55.74 26.73 41 28023 4510 4606418
Empyema 55.42 26.73 23 28041 809 4610119
Kidney enlargement 55.36 26.73 18 28046 311 4610617
Osteoarthritis 54.98 26.73 56 28008 9548 4601380
Status epilepticus 54.75 26.73 42 28022 4921 4606007
Pulmonary hypertension 54.69 26.73 53 28011 8510 4602418
Helicobacter test positive 54.32 26.73 17 28047 258 4610670
Kawasaki's disease 54.12 26.73 14 28050 101 4610827
Blood ethanol increased 53.88 26.73 14 28050 103 4610825
Blood pH decreased 53.35 26.73 24 28040 1030 4609898
Vasculitis 53.32 26.73 39 28025 4252 4606676
Pancytopenia 53.07 26.73 89 27975 24764 4586164
Disseminated intravascular coagulation 52.97 26.73 49 28015 7424 4603504
Photosensitivity reaction 52.91 26.73 40 28024 4586 4606342
Product administered to patient of inappropriate age 52.89 26.73 30 28034 2112 4608816
Intestinal ischaemia 52.77 26.73 31 28033 2332 4608596
Treatment failure 52.75 26.73 66 27998 14081 4596847
Therapy non-responder 52.47 26.73 70 27994 15907 4595021
Feeling abnormal 52.29 26.73 110 27954 36295 4574633
Brain empyema 52.24 26.73 10 28054 11 4610917
Lip erosion 51.89 26.73 17 28047 301 4610627
Pulmonary congestion 51.46 26.73 37 28027 3929 4606999
Pulmonary haemorrhage 51.26 26.73 35 28029 3422 4607506
Red blood cell sedimentation rate 51.17 26.73 11 28053 30 4610898
Gastrointestinal necrosis 50.77 26.73 25 28039 1318 4609610
Foetal death 50.56 26.73 31 28033 2521 4608407
Cardiomegaly 50.32 26.73 40 28024 4937 4605991
Metabolic alkalosis 50.26 26.73 20 28044 630 4610298
Nasal obstruction 50.23 26.73 16 28048 258 4610670
Gastrointestinal inflammation 49.85 26.73 25 28039 1371 4609557
Sedation 49.73 26.73 48 28016 7669 4603259
Autoimmune hepatitis 49.55 26.73 31 28033 2613 4608315
Cardiac failure 49.55 26.73 91 27973 27197 4583731
Cardiovascular disorder 49.38 26.73 42 28022 5698 4605230
Accidental poisoning 49.32 26.73 17 28047 354 4610574
Neutrophil Pelger-Huet anomaly present 49.30 26.73 13 28051 102 4610826
Infection masked 49.21 26.73 11 28053 38 4610890
Atrial fibrillation 49.18 26.73 98 27966 31117 4579811
Cerebral haemorrhage 48.99 26.73 62 28002 13379 4597549
Drug use disorder 48.74 26.73 22 28042 952 4609976
Hallucination 48.47 26.73 71 27993 17597 4593331
Restlessness 48.45 26.73 52 28012 9417 4601511
Embolism venous 48.33 26.73 22 28042 971 4609957
Spinal pain 48.32 26.73 28 28036 2053 4608875
Therapeutic response unexpected 48.31 26.73 45 28019 6877 4604051
Hepatic encephalopathy 48.12 26.73 37 28027 4350 4606578
Abnormal loss of weight 47.88 26.73 24 28040 1315 4609613
Blood creatine increased 47.87 26.73 25 28039 1493 4609435
Nephrotic syndrome 47.69 26.73 31 28033 2792 4608136
Pneumonia pneumococcal 47.29 26.73 19 28045 614 4610314
Beta haemolytic streptococcal infection 47.10 26.73 17 28047 407 4610521
Neutrophil count increased 46.91 26.73 38 28026 4817 4606111
Tachycardia foetal 46.87 26.73 14 28050 180 4610748
Vision blurred 46.67 26.73 84 27980 24719 4586209
Leukopenia 46.62 26.73 78 27986 21658 4589270
Hepatic steatosis 46.41 26.73 42 28022 6186 4604742
Respiratory acidosis 46.33 26.73 25 28039 1596 4609332
Atrial septal defect 46.30 26.73 33 28031 3456 4607472
Pseudomonal sepsis 46.16 26.73 20 28044 784 4610144
Glomerulonephritis membranous 46.15 26.73 17 28047 432 4610496
Onychomycosis 46.15 26.73 21 28043 926 4610002
Gait disturbance 46.13 26.73 105 27959 36535 4574393
Lower respiratory tract infection 46.10 26.73 52 28012 9951 4600977
Fibromyalgia 46.00 26.73 34 28030 3767 4607161
Intentional product use issue 45.26 26.73 44 28020 7091 4603837
Lung disorder 44.99 26.73 57 28007 12314 4598614
Perforated ulcer 44.82 26.73 14 28050 211 4610717
Blood creatine phosphokinase increased 44.82 26.73 63 28001 15036 4595892
Altered state of consciousness 44.75 26.73 46 28018 7925 4603003
Hypovolaemia 44.49 26.73 29 28035 2624 4608304
Angina pectoris 44.49 26.73 50 28014 9531 4601397
Staphylococcal scalded skin syndrome 44.45 26.73 12 28052 104 4610824
Product communication issue 44.41 26.73 11 28053 65 4610863
Biliary sepsis 44.28 26.73 14 28050 220 4610708
Drug screen positive 44.16 26.73 27 28037 2185 4608743
Pruritus genital 44.04 26.73 15 28049 301 4610627
Glomerulonephritis 43.95 26.73 21 28043 1036 4609892
Acute respiratory failure 43.64 26.73 41 28023 6335 4604593
Neonatal cardiac failure 43.48 26.73 9 28055 19 4610909
Dyspnoea exertional 43.31 26.73 51 28013 10221 4600707
Colitis microscopic 43.26 26.73 23 28041 1425 4609503
Microcytic anaemia 43.22 26.73 20 28044 917 4610011
Allergic respiratory disease 43.20 26.73 10 28054 42 4610886
Incorrect product administration duration 42.81 26.73 33 28031 3894 4607034
Thyroid stimulating immunoglobulin increased 42.69 26.73 8 28056 7 4610921
Discoloured vomit 42.65 26.73 12 28052 123 4610805
Gastrointestinal perforation 42.53 26.73 25 28039 1883 4609045
Viral infection 42.36 26.73 45 28019 8053 4602875
Nephritis 42.23 26.73 20 28044 967 4609961
Oxygen saturation decreased 42.04 26.73 59 28005 14062 4596866
Abdominal tenderness 41.87 26.73 24 28040 1724 4609204
Hypersensitivity vasculitis 41.84 26.73 28 28036 2648 4608280
Neck pain 41.65 26.73 53 28011 11499 4599429
Blood urine present 41.54 26.73 33 28031 4068 4606860
Serotonin syndrome 41.47 26.73 42 28022 7110 4603818
Epigastric discomfort 41.44 26.73 20 28044 1009 4609919
Abnormal behaviour 41.41 26.73 54 28010 12002 4598926
Haemarthrosis 41.33 26.73 21 28043 1184 4609744
Diverticulum 41.27 26.73 28 28036 2709 4608219
Drug abuser 41.17 26.73 28 28036 2719 4608209
Vertigo 40.88 26.73 60 28004 14896 4596032
Activated partial thromboplastin time prolonged 40.79 26.73 28 28036 2761 4608167
Cardiac murmur 40.78 26.73 29 28035 3026 4607902
Body temperature decreased 40.74 26.73 27 28037 2512 4608416
Odynophagia 40.70 26.73 24 28040 1818 4609110
Duodenitis haemorrhagic 40.53 26.73 10 28054 58 4610870
Irritability 40.24 26.73 56 28008 13243 4597685
Dermatitis allergic 40.06 26.73 30 28034 3390 4607538
Hepatomegaly 40.02 26.73 31 28033 3684 4607244
Pneumoperitoneum 40.00 26.73 17 28047 635 4610293
Eating disorder 39.98 26.73 31 28033 3689 4607239
Obstructive airways disorder 39.97 26.73 27 28037 2593 4608335
Exposure via ingestion 39.87 26.73 22 28042 1468 4609460
Blood creatinine abnormal 39.75 26.73 19 28045 938 4609990
Scar 39.66 26.73 28 28036 2888 4608040
Pneumonia streptococcal 39.63 26.73 15 28049 412 4610516
Retching 39.61 26.73 30 28034 3449 4607479
Liver transplant 39.41 26.73 21 28043 1307 4609621
Product monitoring error 39.38 26.73 13 28051 236 4610692
Oral discomfort 39.37 26.73 24 28040 1932 4608996
Throat irritation 39.25 26.73 41 28023 7197 4603731
Hypoaesthesia oral 39.19 26.73 29 28035 3218 4607710
Lymphadenitis 39.15 26.73 18 28046 813 4610115
Gastric mucosal lesion 39.08 26.73 13 28051 242 4610686
Granuloma skin 39.04 26.73 12 28052 171 4610757
Burning sensation 38.96 26.73 52 28012 11820 4599108
Ocular icterus 38.84 26.73 21 28043 1346 4609582
Psychomotor hyperactivity 38.82 26.73 32 28032 4157 4606771
Skin erosion 38.74 26.73 18 28046 833 4610095
Renal ischaemia 38.72 26.73 12 28052 176 4610752
Alveolitis 38.66 26.73 18 28046 837 4610091
Acute coronary syndrome 38.42 26.73 32 28032 4218 4606710
Red blood cell sedimentation rate increased 38.36 26.73 29 28035 3324 4607604
Skin hyperpigmentation 38.29 26.73 22 28042 1587 4609341
Flushing 38.28 26.73 67 27997 19285 4591643
Ankylosing spondylitis 38.25 26.73 22 28042 1590 4609338
Pharyngeal paraesthesia 38.17 26.73 12 28052 185 4610743
Blood glucose increased 38.13 26.73 76 27988 24128 4586800
Abscess rupture 37.75 26.73 10 28054 80 4610848
Retinopathy of prematurity 37.75 26.73 13 28051 270 4610658
Corneal leukoma 37.71 26.73 8 28056 20 4610908
Diarrhoea haemorrhagic 37.67 26.73 26 28038 2587 4608341
Hypoalbuminaemia 37.56 26.73 28 28036 3142 4607786
Dermatomyositis 37.48 26.73 17 28047 744 4610184
Accidental exposure to product 37.40 26.73 55 28009 13677 4597251
Product taste abnormal 37.33 26.73 19 28045 1075 4609853
Still's disease 36.97 26.73 12 28052 206 4610722
Angular cheilitis 36.79 26.73 11 28053 142 4610786
Visual impairment 36.72 26.73 66 27998 19394 4591534
Implant site extravasation 36.60 26.73 14 28050 396 4610532
Anion gap 36.34 26.73 12 28052 218 4610710
Gastritis bacterial 36.22 26.73 10 28054 95 4610833
Nephropathy 36.18 26.73 23 28041 1993 4608935
Mental disorder 36.15 26.73 40 28024 7494 4603434
Anti-thyroid antibody positive 35.97 26.73 11 28053 154 4610774
Tricuspid valve incompetence 35.78 26.73 27 28037 3087 4607841
Evans syndrome 35.71 26.73 11 28053 158 4610770
Nasal polyps 35.70 26.73 14 28050 424 4610504
Pupils unequal 35.66 26.73 15 28049 546 4610382
Abscess 35.62 26.73 32 28032 4668 4606260
Oral pruritus 35.45 26.73 14 28050 432 4610496
Rash morbilliform 35.34 26.73 18 28046 1020 4609908
Meningoencephalitis bacterial 35.28 26.73 9 28055 61 4610867
Glomerulonephritis minimal lesion 35.27 26.73 11 28053 165 4610763
Lip erythema 35.15 26.73 9 28055 62 4610866
Gastrointestinal injury 35.04 26.73 12 28052 245 4610683
Nephrolithiasis 35.03 26.73 43 28021 8996 4601932
Oesophageal discomfort 34.98 26.73 10 28054 109 4610819
Drug withdrawal syndrome 34.86 26.73 51 28013 12621 4598307
Blood pressure diastolic decreased 34.79 26.73 22 28042 1889 4609039
Oesophageal rupture 34.76 26.73 12 28052 251 4610677
Pancreatitis 34.66 26.73 60 28004 17118 4593810
Electrocardiogram QT shortened 34.58 26.73 10 28054 114 4610814
Hypertransaminasaemia 34.53 26.73 19 28045 1261 4609667
Skin lesion 34.44 26.73 39 28025 7494 4603434
Status asthmaticus 34.41 26.73 12 28052 259 4610669
Intestinal ulcer 34.26 26.73 14 28050 473 4610455
Thrombocytosis 34.19 26.73 21 28043 1713 4609215
Duodenal perforation 34.14 26.73 13 28051 363 4610565
Rheumatoid arthritis 34.11 26.73 74 27990 24925 4586003
Aspiration 34.10 26.73 28 28036 3617 4607311
Anion gap increased 34.08 26.73 15 28049 611 4610317
Genital odour 34.06 26.73 6 28058 2 4610926
Nasal congestion 34.04 26.73 46 28018 10580 4600348
Sudden death 33.92 26.73 33 28031 5322 4605606
Staphylococcal infection 33.83 26.73 46 28018 10642 4600286
Gastrointestinal erosion 33.82 26.73 12 28052 273 4610655
Ecchymosis 33.72 26.73 25 28039 2782 4608146
Urinary retention 33.65 26.73 44 28020 9803 4601125
Myocardial infarction 33.62 26.73 113 27951 49263 4561665
Palmar erythema 33.58 26.73 13 28051 380 4610548
Blood pressure systolic decreased 33.57 26.73 20 28044 1544 4609384
Implant site infection 33.45 26.73 15 28049 639 4610289
Duodenal ulcer repair 33.44 26.73 7 28057 16 4610912
Blood potassium increased 33.41 26.73 32 28032 5063 4605865
Urticaria chronic 33.31 26.73 10 28054 131 4610797
Cutaneous symptom 33.24 26.73 10 28054 132 4610796
Dry eye 33.17 26.73 33 28031 5468 4605460
Blood parathyroid hormone decreased 33.14 26.73 13 28051 394 4610534
Crying 33.11 26.73 35 28029 6228 4604700
Fluid intake reduced 33.07 26.73 18 28046 1169 4609759
Pneumococcal infection 32.90 26.73 11 28053 208 4610720
Electrolyte imbalance 32.90 26.73 28 28036 3801 4607127
Respiratory rate increased 32.82 26.73 25 28039 2898 4608030
Feeding intolerance 32.65 26.73 9 28055 85 4610843
Depressed mood 32.55 26.73 41 28023 8803 4602125
Accidental exposure to product by child 32.54 26.73 20 28044 1633 4609295
Systemic inflammatory response syndrome 32.50 26.73 21 28043 1872 4609056
Nystagmus 32.47 26.73 23 28041 2385 4608543
Psychomotor skills impaired 32.32 26.73 16 28048 853 4610075
Ventricular fibrillation 32.16 26.73 32 28032 5305 4605623
Nephritis allergic 32.12 26.73 10 28054 149 4610779
Cheilitis 31.91 26.73 19 28045 1465 4609463
Hepatitis fulminant 31.90 26.73 19 28045 1466 4609462
Migraine 31.83 26.73 51 28013 13658 4597270
Urinary incontinence 31.70 26.73 37 28027 7343 4603585
Vascular purpura 31.67 26.73 14 28050 576 4610352
Glomerulonephropathy 31.66 26.73 9 28055 96 4610832
Upper gastrointestinal perforation 31.63 26.73 6 28058 6 4610922
Hyperchlorhydria 31.63 26.73 13 28051 446 4610482
Anaphylactoid reaction 31.53 26.73 20 28044 1727 4609201
Skin discolouration 31.43 26.73 40 28024 8678 4602250
Premature baby 31.42 26.73 43 28021 10008 4600920
Abdominal rigidity 31.29 26.73 14 28050 593 4610335
Cerebral atrophy congenital 31.15 26.73 6 28058 7 4610921
Anhidrosis 30.93 26.73 9 28055 105 4610823
Brain herniation 30.88 26.73 18 28046 1334 4609594
Haemolysis 30.77 26.73 23 28041 2592 4608336
Protein-losing gastroenteropathy 30.74 26.73 10 28054 173 4610755
Focal segmental glomerulosclerosis 30.73 26.73 14 28050 619 4610309
Genital tract inflammation 30.71 26.73 7 28057 27 4610901
Gastrointestinal hypermotility 30.62 26.73 9 28055 109 4610819
Ventricular septal defect 30.45 26.73 22 28042 2353 4608575
Hypoglycaemia 30.44 26.73 59 28005 18350 4592578
Delirium 30.38 26.73 48 28016 12704 4598224
Vulval disorder 30.22 26.73 10 28054 183 4610745
Intracranial pressure increased 30.15 26.73 20 28044 1864 4609064
Skin necrosis 30.11 26.73 21 28043 2124 4608804
Postmortem blood drug level increased 30.11 26.73 9 28055 116 4610812
Body temperature increased 30.10 26.73 33 28031 6119 4604809
Renal cortical necrosis 29.98 26.73 8 28056 66 4610862
Non-cardiac chest pain 29.96 26.73 18 28046 1411 4609517
Colitis ischaemic 29.85 26.73 23 28041 2712 4608216
Sinus bradycardia 29.82 26.73 28 28036 4321 4606607
Type IV hypersensitivity reaction 29.80 26.73 16 28048 1011 4609917
Eructation 29.59 26.73 20 28044 1923 4609005
Glomerulonephritis chronic 29.56 26.73 8 28056 70 4610858
Purulent discharge 29.49 26.73 18 28046 1452 4609476
Necrotising enterocolitis neonatal 29.43 26.73 9 28055 126 4610802
Hypoacusis 29.42 26.73 33 28031 6276 4604652
Ear pain 29.39 26.73 26 28038 3716 4607212
Infected dermal cyst 29.04 26.73 9 28055 132 4610796
Skin laceration 29.03 26.73 29 28035 4829 4606099
Bone loss 28.93 26.73 14 28050 710 4610218
Hyperglycaemia 28.90 26.73 44 28020 11278 4599650
Contraindicated product prescribed 28.89 26.73 10 28054 211 4610717
Ischaemic hepatitis 28.85 26.73 13 28051 560 4610368
Weight increased 28.79 26.73 88 27976 36493 4574435
Stress 28.77 26.73 41 28023 9907 4601021
Pleurisy 28.74 26.73 21 28043 2285 4608643
Flatulence 28.71 26.73 37 28027 8127 4602801
Optic neuritis 28.68 26.73 22 28042 2577 4608351
Diverticulum intestinal haemorrhagic 28.53 26.73 13 28051 575 4610353
Genital ulceration 28.46 26.73 10 28054 221 4610707
Substance dependence 28.34 26.73 8 28056 83 4610845
Infectious pleural effusion 28.34 26.73 13 28051 584 4610344
Platelet count decreased 28.30 26.73 85 27979 34917 4576011
Symblepharon 28.09 26.73 8 28056 86 4610842
Haemophilus infection 28.02 26.73 11 28053 334 4610594
Portal vein phlebitis 28.01 26.73 6 28058 16 4610912
Urinary tract infection 27.97 26.73 96 27968 42294 4568634
Nasal pruritus 27.92 26.73 9 28055 151 4610777
Pyroglutamate increased 27.92 26.73 8 28056 88 4610840
Type I hypersensitivity 27.83 26.73 15 28049 955 4609973
Adverse drug reaction 27.82 26.73 50 28014 14689 4596239
Urinary sediment present 27.72 26.73 10 28054 239 4610689
Keratitis 27.69 26.73 15 28049 965 4609963
Necrosis 27.66 26.73 20 28044 2142 4608786
Dysgeusia 27.63 26.73 50 28014 14769 4596159
Extradural haematoma 27.61 26.73 13 28051 620 4610308
Conduction disorder 27.59 26.73 14 28050 787 4610141
Tenderness 27.55 26.73 23 28041 3040 4607888
Menorrhagia 27.42 26.73 25 28039 3717 4607211
Patient uncooperative 27.37 26.73 7 28057 48 4610880
Electrocardiogram abnormal 27.33 26.73 22 28042 2764 4608164
Photophobia 27.28 26.73 25 28039 3741 4607187
Rheumatoid nodule 27.22 26.73 14 28050 810 4610118
Anoxia 27.18 26.73 9 28055 165 4610763
Anal incontinence 27.11 26.73 23 28041 3108 4607820
Oligohydramnios 27.08 26.73 16 28048 1216 4609712
Joint effusion 27.05 26.73 19 28045 1944 4608984
Acute haemorrhagic oedema of infancy 27.01 26.73 6 28058 20 4610908
Mucosal necrosis 27.00 26.73 7 28057 51 4610877
Blood fibrinogen increased 26.97 26.73 11 28053 370 4610558
Anti-transglutaminase antibody 26.89 26.73 5 28059 4 4610924
Anterior interosseous syndrome 26.89 26.73 5 28059 4 4610924
Albuminuria 26.88 26.73 9 28055 171 4610757
Lacrimation increased 26.88 26.73 27 28037 4526 4606402
Blood calcium decreased 26.80 26.73 25 28039 3826 4607102

Pharmacologic Action:

SourceCodeDescription
ATC C01EB16 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
OTHER CARDIAC PREPARATIONS
Other cardiac preparations
ATC G02CC01 GENITO URINARY SYSTEM AND SEX HORMONES
OTHER GYNECOLOGICALS
OTHER GYNECOLOGICALS
Antiinflammatory products for vaginal administration
ATC M01AE01 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC M02AA13 MUSCULO-SKELETAL SYSTEM
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
Antiinflammatory preparations, non-steroids for topical use
ATC R02AX02 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Other throat preparations
ATC M01AE51 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
ATC N02AJ08 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
ATC N02AJ19 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with non-opioid analgesics
FDA EPC N0000175722 Nonsteroidal Anti-inflammatory Drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
FDA Chemical/Ingredient N0000175721 Nonsteroidal Anti-inflammatory Compounds

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Severe pain indication 76948002
Patent ductus arteriosus indication 83330001 DOID:13832
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Influenza-like symptoms indication 315642008
Fever indication 386661006
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001
Acute postoperative pain indication 107401000119105
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Agoraphobia contraindication 70691001 DOID:593
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Atrophic gastritis contraindication 84568007 DOID:8929
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Acute abdominal pain contraindication 116290004
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Liver function tests abnormal contraindication 166603001
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Impaired renal function disorder contraindication 197663003
Cerebrovascular accident contraindication 230690007
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Exacerbation of asthma contraindication 281239006
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Thromboembolic disorder contraindication 371039008
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001
Hypertensive urgency contraindication 443482000
Smokes tobacco daily contraindication 449868002
Significant Bleeding contraindication
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) NEOPROFEN RECORDATI RARE N021903 April 13, 2006 RX INJECTABLE INTRAVENOUS 6342530 Nov. 14, 2020 CLOSURE OF A CLINICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN PREMATURE INFANTS WEIGHING BETWEEN 500 AND 1500G, WHO ARE NO MORE THAN 32 WEEKS GESTATIONAL AGE WHEN USUAL MEDICAL MANAGEMENT IS INEFFECTIVE
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) NEOPROFEN RECORDATI RARE N021903 April 13, 2006 RX INJECTABLE INTRAVENOUS 6342530 Nov. 14, 2020 TREATMENT OF PATENT DUCTUS ARTERIOSUS
EQ 20MG BASE/2ML (EQ 10MG BASE/ML) NEOPROFEN RECORDATI RARE N021903 April 13, 2006 RX INJECTABLE INTRAVENOUS 6344479 March 20, 2021 CLOSURE OF A CLINICALLY SIGNIFICANT PATENT DUCTUS ARTERIOSUS IN PREMATURE INFANTS WEIGHING BETWEEN 500 AND 1500G, WHO ARE NO MORE THAN 32 WEEKS GESTATIONAL AGE WHEN USUAL MEDICAL MANAGEMENT IS INEFFECTIVE
400MG/4ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 DISCN SOLUTION INTRAVENOUS 6727286 Nov. 27, 2021 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 6727286 Nov. 27, 2021 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
EQ 200MG FREE ACID AND POTASSIUM SALT ADVIL PM GLAXOSMITHKLINE N021393 Dec. 21, 2005 OTC CAPSULE ORAL 8883849 Jan. 17, 2022 A METHOD OF TREATING A PATIENT SUFFERING FROM A PAIN ASSOCIATED SLEEP DISTURBANCE COMPRISING ADMINISTERING A LIQUID COMPOSITION FORMULATED INSIDE A SOFT GEL CAPSULE, AS CLAIMED, TO THE PATIENT
800MG DUEXIS HORIZON N022519 April 23, 2011 RX TABLET ORAL 8067451 July 18, 2026 RELIEF OF SIGNS AND SYMPTOMS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS AND TO DECREASE RISK OF DEVELOPING UPPER GASTROINTESTINAL ULCERS IN PATIENTS WHO ARE TAKING IBUPROFEN FOR THOSE INDICATIONS
800MG DUEXIS HORIZON N022519 April 23, 2011 RX TABLET ORAL 8501228 July 18, 2026 RELIEF OF SIGNS AND SYMPTOMS OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS AND TO DECREASE RISK OF DEVELOPING UPPER GASTROINTESTINAL ULCERS IN PATIENTS WHO ARE TAKING IBUPROFEN FOR THOSE INDICATIONS
800MG/200ML (4MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 Jan. 25, 2019 RX SOLUTION INTRAVENOUS 8735452 Sept. 30, 2029 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/200ML (4MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 Jan. 25, 2019 RX SOLUTION INTRAVENOUS 8871810 Sept. 30, 2029 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 8735452 Sept. 30, 2029 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 8871810 Sept. 30, 2029 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 9114068 Sept. 30, 2029 METHODS OF TREATING PAIN, INFLAMMATION AND/OR FEVER WITH INTRAVENOUS IBUPROFEN SUCH THAT MEAN ARTERIAL BLOOD PRESSURE DOES NOT INCREASE THE DOSAGE INTERVAL
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 9138404 Sept. 30, 2029 METHODS OF TREATING PAIN, INFLAMMATION AND/OR FEVER IN A CRITICALLY ILL PATIENT WITH INTRAVENOUS IBUPROFEN IN NEED THEREOF
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 9295639 Sept. 30, 2029 METHODS OF TREATING PAIN, INFLAMMATION AND/OR FEVER IN A CRITICALLY ILL PATIENT WITH INTRAVENOUS IBUPROFEN IN NEED THEREOF
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 9649284 Sept. 30, 2029 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS IN A CRITICALLY ILL PATIENT WITH INTRAVENOUS IBUPROFEN IN NEED THEREOF
800MG/200ML (4MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 Jan. 25, 2019 RX SOLUTION INTRAVENOUS 9012508 Sept. 14, 2030 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/8ML (100MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 June 11, 2009 RX SOLUTION INTRAVENOUS 9012508 Sept. 14, 2030 MANAGEMENT OF MILD TO MODERATE PAIN, MANAGEMENT OF MODERATE TO SEVERE PAIN AS AN ADJUNCT TO OPIOID ANALGESICS, REDUCTION IN FEVER THROUGH ANTI-INFLAMMATORY, ANALGESIC, AND ANTIPYRETIC ACTIVITY
800MG/200ML (4MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 Jan. 25, 2019 RX SOLUTION INTRAVENOUS 9072661 March 16, 2032 METHODS OF TREATING PAIN, INFLAMMATION, FEVER, PATENT DUCTUS ARTERIOSIS WITH AQUEOUS COMPOSITION
800MG/200ML (4MG/ML) CALDOLOR CUMBERLAND PHARMS N022348 Jan. 25, 2019 RX SOLUTION INTRAVENOUS 9072710 March 16, 2032 METHODS OF MAKING AQUEOUS COMPOSITION AND TREATING PAIN, INFLAMMATION, FEVER, PATENT DUCTUS ARTERIOSIS WITH AQUEOUS COMPOSITION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
125MG ADVIL DUAL ACTION WITH ACETAMINOPHEN PFIZER INC N211733 Feb. 28, 2020 OTC TABLET ORAL Feb. 28, 2023 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 5.14 WOMBAT-PK CHEMBL
Prostaglandin G/H synthase 1 Enzyme INHIBITOR IC50 5.12 WOMBAT-PK CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.48 CHEMBL
Cytochrome P450 2C9 Enzyme Ki 4.30 WOMBAT-PK
Arachidonate 5-lipoxygenase Enzyme WOMBAT-PK
Sodium-coupled monocarboxylate transporter 1 Transporter INHIBITOR IC50 4.20 IUPHAR
Interleukin-8 Cytokine IC50 7.30 CHEMBL
Acid-sensing ion channel 1 Ion channel BLOCKER IC50 3.53 SCIENTIFIC LITERATURE
Aldo-keto reductase family 1 member C2 Enzyme IC50 4.37 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.96 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 6.07 CHEMBL
Serum albumin Secreted IC50 5.52 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 4.32 CHEMBL
Dehydrogenase/reductase SDR family member 9 Unclassified IC50 4 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.54 CHEMBL
Cyclooxygenase Enzyme IC50 5.70 CHEMBL
Prostaglandin G/H synthase 2 Enzyme Ki 5.05 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 5.96 CHEMBL
Solute carrier family 22 member 6 Transporter Ki 5.33 CHEMBL
Prostaglandin G/H synthase 1 Enzyme Ki 5.05 CHEMBL
Prostaglandin-H2 D-isomerase Enzyme IC50 4.89 CHEMBL

External reference:

IDSource
D007052 MESH_DESCRIPTOR_UI
4032936 VUID
N0000189536 NUI
C0074814 UMLSCUI
D00126 KEGG_DRUG
38268001 SNOMEDCT_US
2133 MMSL
5640 RXNORM
387207008 SNOMEDCT_US
4862 MMSL
d00015 MMSL
7027 MMSL
4017840 VANDF
002377 NDDF
3672 PUBCHEM_CID
CHEBI:132922 CHEBI
CHEMBL521 ChEMBL_ID
CHEMBL175 ChEMBL_ID
CHEMBL427526 ChEMBL_ID
C016106 MESH_SUPPLEMENTAL_RECORD_UI
DB01050 DRUGBANK_ID
N01ORX9D6S UNII
57469-77-9 SECONDARY_CAS_RN
IBP PDB_CHEM_ID
2118 INN_ID
CHEMBL1201141 ChEMBL_ID
CHEMBL1241153 ChEMBL_ID
CHEMBL3989408 ChEMBL_ID
2713 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense ibuprofen pm HUMAN OTC DRUG LABEL 2 0113-0050 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
Good Sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0057 SUSPENSION 50 mg ORAL ANDA 9 sections
Good Sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0074 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0166 SUSPENSION 100 mg ORAL ANDA 9 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0298 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 9 sections
Good Sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0461 TABLET, CHEWABLE 100 mg ORAL ANDA 9 sections
Good Sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0517 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0604 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0647 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
Good Sense Ibuprofen HUMAN OTC DRUG LABEL 1 0113-0660 SUSPENSION 100 mg ORAL ANDA 9 sections
Good Sense Ibuprofen HUMAN OTC DRUG LABEL 1 0113-0685 SUSPENSION 100 mg ORAL ANDA 9 sections
Basic Care ibuprofen HUMAN OTC DRUG LABEL 1 0113-0788 TABLET, CHEWABLE 100 mg ORAL ANDA 9 sections
good sense ibuprofen HUMAN OTC DRUG LABEL 1 0113-0897 SUSPENSION 100 mg ORAL ANDA 9 sections
basic care childrens ibuprofen HUMAN OTC DRUG LABEL 1 0113-1461 TABLET, CHEWABLE 100 mg ORAL ANDA 9 sections
Good Sense Childrens Ibuprofen HUMAN OTC DRUG LABEL 1 0113-2461 TABLET, CHEWABLE 100 mg ORAL ANDA 9 sections
basic care ibuprofen HUMAN OTC DRUG LABEL 1 0113-7131 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 9 sections
basic care ibuprofen HUMAN OTC DRUG LABEL 1 0113-7517 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
Basic Care Ibuprofen HUMAN OTC DRUG LABEL 1 0113-7604 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
basic care childrens ibuprofen HUMAN OTC DRUG LABEL 1 0113-7660 SUSPENSION 100 mg ORAL ANDA 9 sections
Basic Care childrens ibuprofen HUMAN OTC DRUG LABEL 1 0113-7897 SUSPENSION 100 mg ORAL ANDA 9 sections
IBUPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 0121-1548 SUSPENSION 100 mg ORAL ANDA 14 sections
Childrens Ibuprofen HUMAN OTC DRUG LABEL 1 0121-1836 SUSPENSION 100 mg ORAL ANDA 10 sections
IBUPROFEN HUMAN PRESCRIPTION DRUG LABEL 1 0121-4774 SUSPENSION 100 mg ORAL ANDA 14 sections
Oxycodone hydrochloride and Ibuprofen HUMAN PRESCRIPTION DRUG LABEL 2 0228-4029 TABLET, FILM COATED 400 mg ORAL ANDA 16 sections
IBUPROFEN HUMAN OTC DRUG LABEL 1 0363-0003 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 16 sections
Ibuprofen PM HUMAN OTC DRUG LABEL 2 0363-0050 TABLET, FILM COATED 200 mg ORAL ANDA 9 sections
Ibuprofen HUMAN OTC DRUG LABEL 1 0363-0057 SUSPENSION 50 mg ORAL ANDA 9 sections
walprofen congestion relief and pain HUMAN OTC DRUG LABEL 2 0363-0158 TABLET, FILM COATED 200 mg ORAL ANDA 16 sections
ibuprofen HUMAN OTC DRUG LABEL 1 0363-0166 SUSPENSION 100 mg ORAL ANDA 9 sections
Ibuprofen HUMAN OTC DRUG LABEL 1 0363-0197 CAPSULE, LIQUID FILLED 200 mg ORAL ANDA 10 sections