butriptyline indications/contra

Stem definitionDrug idCAS RN
antidepressants, dibenzo[a,d]cycloheptane or cyclopheptene derivatives 455 35941-65-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butriptyline hydrochloride
  • butriptyline
  • butriptylene
  • butriptyline HCl
a tricyclic antianxiety and antidepressive agent similar to, but with less side effects than amitriptyline; minor descriptor (75-86); on line & INDEX MEDICUS search DIBENZOCYCLOHEPTENES (75-86); RN given refers to parent cpd
  • Molecular weight: 293.45
  • Formula: C21H27N
  • CLOGP: 5.55
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 0
  • TPSA: 3.24
  • ALOGS: -5.92
  • ROTB: 4

Drug dosage:

DoseUnitRoute
75 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AA15 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007 DOID:2848

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter Ki 5.40 PDSP
Sodium-dependent serotonin transporter Transporter Ki 5.87 PDSP
Sodium-dependent noradrenaline transporter Transporter Ki 5.29 PDSP

External reference:

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IDSource
C1108795 UMLSCUI
D03199 KEGG_DRUG
21772 PUBCHEM_CID
19895 RXNORM
115544001 SNOMEDCT_US
386997004 SNOMEDCT_US
003938 NDDF
CHEBI:135227 CHEBI
DB09016 DRUGBANK_ID
CHEMBL2106170 ChEMBL_ID
CHEMBL2110816 ChEMBL_ID
LIJ2H8658W UNII
5585-73-9 SECONDARY_CAS_RN
C100242 MESH_SUPPLEMENTAL_RECORD_UI
2123 INN_ID

Pharmaceutical products:

None