iprindole indications/contra

Stem definitionDrug idCAS RN
1478 5560-72-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iprindole
  • pramindole
A tricyclic antidepressant that has actions and uses similar to those of AMITRIPTYLINE, but has only weak antimuscarinic and sedative effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p257)
  • Molecular weight: 284.45
  • Formula: C19H28N2
  • CLOGP: 5.66
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 8.17
  • ALOGS: -4.28
  • ROTB: 4

Drug dosage:

DoseUnitRoute
90 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AA13 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Non-selective monoamine reuptake inhibitors
MeSH PA D000928 Antidepressive Agents
MeSH PA D000929 Antidepressive Agents, Tricyclic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.16 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent dopamine transporter Transporter Ki 5.19 PDSP
Histamine H1 receptor GPCR Ki 6.92 PDSP
Sodium-dependent serotonin transporter Transporter Ki 5.79 PDSP
Sodium-dependent noradrenaline transporter Transporter Ki 5.90 PDSP

External reference:

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IDSource
N0000166960 NUI
C0022057 UMLSCUI
D04605 KEGG_DRUG
69U0IKR8FP UNII
1854 INN_ID
21722 PUBCHEM_CID
5979 RXNORM
321826008 SNOMEDCT_US
419144003 SNOMEDCT_US
N0000166960 NDFRT
003982 NDDF
CHEMBL126224 ChEMBL_ID
CHEBI:135177 CHEBI
D007488 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None