butoconazole indications/contra

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 450 64872-77-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • butoconazole
  • butaconazole
  • butoconazole nitrate
  • butaconazole nitrate
  • femstat
  • Molecular weight: 411.77
  • Formula: C19H17Cl3N2S
  • CLOGP: 6.86
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 17.82
  • ALOGS: -5.70
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.10 g V

Approvals:

DateAgencyCompanyOrphan
Dec. 21, 1995 FDA BAYER

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC G01AF15 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents
FDA EPC N0000175487 Azole Antifungal
FDA Chemical/Ingredient N0000008217 Azoles

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Candidal vulvovaginitis indication 72605008 DOID:2272

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lanosterol 14-alpha demethylase Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

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IDSource
4019649 VUID
N0000147742 NUI
C0054259 UMLSCUI
D00880 KEGG_DRUG
0Q771797PH UNII
4496 INN_ID
64872-76-0 SECONDARY_CAS_RN
DB00639 DRUGBANK_ID
4019649 VANDF
N0000006911 NDFRT
N0000147742 NDFRT
19884 RXNORM
372878005 SNOMEDCT_US
84844007 SNOMEDCT_US
004962 NDDF
CHEMBL1295 ChEMBL_ID
47472 PUBCHEM_CID
CHEMBL1200398 ChEMBL_ID
C017125 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:3240 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
gynazole 1 HUMAN PRESCRIPTION DRUG LABEL 1 45802-396 CREAM 100 mg VAGINAL ANDA 13 sections