flutrimazole Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
1227 119006-77-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • UR-4056
  • flutrimazole
  • Molecular weight: 346.38
  • Formula: C22H16F2N2
  • CLOGP: 4.58
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 17.82
  • ALOGS: -5.59
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AC16 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC G01AF18 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Imidazole derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.21 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Nuclear receptor subfamily 1 group I member 2 Nuclear hormone receptor EC50 5.21 CHEMBL
Bile acid receptor Nuclear hormone receptor IC50 4.86 CHEMBL

External reference:

IDSource
C0172907 UMLSCUI
D07193 KEGG_DRUG
776S0UP252 UNII
6460 INN_ID
61773 RXNORM
009433 NDDF
697966001 SNOMEDCT_US
3401 PUBCHEM_CID
CHEMBL2107430 ChEMBL_ID
C076986 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:82864 CHEBI

Pharmaceutical products:

None