DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tegafur 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
uridine derivatives used as antiviral agents and as antineoplastics
4398
17902-23-7
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tegafur
ftorafur
FT-207
florafur
futraful
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
Molecular weight: 200.17
Formula: C8H9FN2O3
CLOGP: -0.06
LIPINSKI: 0
HAC: 5
HDO: 1
TPSA: 58.64
ALOGS: -1.16
ROTB: 1
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
8.69 hours
Lombardo F, Berellini G, Obach RS
CL (Clearance)
0.95 mL/min/kg
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.62 L/kg
Lombardo F, Berellini G, Obach RS
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Approvals:
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Date
Agency
Company
Orphan
March 1, 1999
PMDA
Taiho Pharmaceutical Co, Ltd
March 14, 2011
EMA
Nordic Group BV
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
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MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Bone marrow failure
72.12
47.42
20
305
51087
79692976
Myelosuppression
53.23
47.42
15
310
40281
79703782
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FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
L01BC03
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
ATC
L01BC53
ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
MeSH PA
D000963
Antimetabolites
MeSH PA
D000964
Antimetabolites, Antineoplastic
MeSH PA
D000970
Antineoplastic Agents
MeSH PA
D009676
Noxae
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Malignant tumor of stomach
indication
363349007
DOID:10534
Hormone receptor pozitive breast cancer
indication
417181009
HER2negative breast cancer
indication
767444009
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.81
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
S7W
PDB_CHEM_ID
007248
NDDF
10513
IUPHAR_LIGAND_ID
1548R74NSZ
UNII
395897006
SNOMEDCT_US
421459003
SNOMEDCT_US
4415
INN_ID
4582
RXNORM
5386
PUBCHEM_CID
C0016778
UMLSCUI
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Pharmaceutical products:
None
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L1000
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tegafur