alpha-tocopherol acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4195 58-95-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alpha-tocopherol acetate
  • Vitamin E acetate
  • (+)-alpha-tocopherol acetate
  • alfacol
  • contopheron
  • D-alpha-Tocopherol acetate
  • .alpha.-tocopherol acetate, dl-
  • .ALPHA.-TOCOPHEROL ACETATE, D-
  • .ALPHA.-TOCOPHEROL ACETATE
  • alpha-tocopherol acetate, dl-
  • tocopherol acetate
  • Molecular weight: 472.75
  • Formula: C31H52O3
  • CLOGP: 12
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -8.21
  • ROTB: 14
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1705.85 10.07 6473 781451 320391 89520132
Systemic lupus erythematosus 1694.38 10.07 6926 780998 354970 89485553
Glossodynia 1452.68 10.07 6091 781833 315688 89524835
Hand deformity 1212.48 10.07 5447 782477 290915 89549608
Arthropathy 1178.32 10.07 6284 781640 359958 89480565
Abdominal discomfort 1061.96 10.07 7443 780481 469885 89370638
Alopecia 1047.15 10.07 7626 780298 487445 89353078
Wound 986.54 10.07 5217 782707 297763 89542760
Completed suicide 978.19 10.07 74 787850 144984 89695539
Toxicity to various agents 903.92 10.07 707 787217 287139 89553384
Synovitis 879.34 10.07 5383 782541 324369 89516154
Maternal exposure during pregnancy 838.05 10.07 5679 782245 354384 89486139
Anti-cyclic citrullinated peptide antibody positive 819.76 10.07 4144 783780 232289 89608234
Swelling 817.45 10.07 6335 781589 412723 89427800
Pericarditis 813.87 10.07 4555 783369 265596 89574927
Contraindicated product administered 730.82 10.07 5026 782898 315113 89525410
Discomfort 728.24 10.07 4474 783450 269861 89570662
Joint swelling 671.85 10.07 7006 780918 496294 89344229
Duodenal ulcer perforation 664.13 10.07 3728 784196 217560 89622963
Infusion related reaction 659.64 10.07 6013 781911 410767 89429756
Helicobacter infection 611.55 10.07 3715 784209 223135 89617388
Death 595.38 10.07 2008 785916 454543 89385980
Intentional overdose 557.39 10.07 77 787847 93757 89746766
Drug interaction 549.20 10.07 976 786948 275477 89565046
Rheumatoid arthritis 525.25 10.07 5135 782789 357479 89483044
Pain 491.80 10.07 11721 776203 984620 88855903
Rheumatoid factor positive 489.35 10.07 2853 785071 168797 89671726
Febrile neutropenia 451.57 10.07 426 787498 157923 89682600
Psoriatic arthropathy 444.93 10.07 3453 784471 224882 89615641
Hepatic enzyme increased 420.63 10.07 4891 783033 355845 89484678
Drug abuse 407.69 10.07 106 787818 82241 89758282
Therapeutic product effect decreased 383.33 10.07 3893 784031 273678 89566845
Suicide attempt 375.29 10.07 96 787828 75303 89765220
Arthralgia 360.18 10.07 9082 778842 769440 89071083
Musculoskeletal stiffness 356.48 10.07 4045 783879 292487 89548036
Impaired healing 351.24 10.07 3342 784582 230857 89609666
Disease progression 350.26 10.07 511 787413 156104 89684419
Malignant neoplasm progression 347.30 10.07 253 787671 106617 89733906
Product use issue 342.66 10.07 4377 783547 325542 89514981
Depressed level of consciousness 334.02 10.07 108 787816 72676 89767847
Folliculitis 318.84 10.07 2941 784983 201412 89639111
Acute kidney injury 318.56 10.07 1566 786358 318821 89521702
Constipation 311.89 10.07 1315 786609 279080 89561443
Neutropenia 308.77 10.07 966 786958 223938 89616585
Rheumatic fever 307.80 10.07 2333 785591 150788 89689735
Blister 295.43 10.07 3454 784470 251544 89588979
Cardiac arrest 292.49 10.07 288 787636 104647 89735876
Overdose 290.79 10.07 582 787342 157127 89683396
Drug intolerance 272.04 10.07 5430 782494 442161 89398362
Muscle injury 264.82 10.07 2521 785403 174133 89666390
Electrocardiogram QT prolonged 263.40 10.07 151 787773 72305 89768218
Sleep disorder due to general medical condition, insomnia type 254.23 10.07 1953 785971 126741 89713782
Irritable bowel syndrome 250.09 10.07 2832 785092 204616 89635907
Swollen joint count increased 247.32 10.07 1736 786188 109470 89731053
Type 2 diabetes mellitus 245.19 10.07 2775 785149 200469 89640054
Lactic acidosis 244.04 10.07 68 787856 50395 89790128
Fibromyalgia 234.85 10.07 2785 785139 203484 89637039
Exposure during pregnancy 234.35 10.07 3132 784792 235278 89605245
Somnolence 231.53 10.07 982 786942 208102 89632421
Hypersensitivity 230.95 10.07 5375 782549 449302 89391221
Nausea 228.85 10.07 7640 780284 1102676 88737847
Treatment failure 227.90 10.07 3811 784113 300117 89540406
Hyperhidrosis 227.24 10.07 532 787392 135773 89704750
Nasopharyngitis 221.54 10.07 4860 783064 402244 89438279
Hyponatraemia 221.18 10.07 523 787401 133015 89707508
Hypotension 219.02 10.07 1793 786131 323604 89516919
Hip arthroplasty 218.49 10.07 1269 786655 74939 89765584
Sedation 216.61 10.07 74 787850 48097 89792426
Lower respiratory tract infection 216.26 10.07 3218 784706 247441 89593082
Knee arthroplasty 215.47 10.07 1349 786575 81833 89758690
Blood cholesterol increased 208.27 10.07 2742 785182 205270 89635253
C-reactive protein abnormal 205.26 10.07 1847 786077 125582 89714941
Cardiac failure 197.62 10.07 409 787515 109087 89731436
Ill-defined disorder 197.24 10.07 2466 785458 182425 89658098
Bradycardia 192.93 10.07 268 787656 83579 89756944
Drug ineffective for unapproved indication 191.43 10.07 178 787746 66466 89774057
Stomatitis 176.93 10.07 3363 784561 271335 89569188
Liver injury 175.14 10.07 2259 785665 168308 89672215
Tremor 173.50 10.07 713 787211 152460 89688063
Drug reaction with eosinophilia and systemic symptoms 172.00 10.07 78 787846 42680 89797843
Agitation 171.50 10.07 198 787726 66900 89773623
Red blood cell sedimentation rate abnormal 170.99 10.07 531 787393 23673 89816850
Neoplasm progression 170.02 10.07 87 787837 44399 89796124
Renal failure 168.43 10.07 579 787345 130428 89710095
Serotonin syndrome 167.26 10.07 60 787864 37827 89802696
Myelosuppression 163.76 10.07 135 787789 53456 89787067
Diarrhoea 160.31 10.07 6609 781315 932581 88907942
Rhabdomyolysis 159.26 10.07 127 787797 51129 89789394
Contusion 155.12 10.07 3056 784868 248160 89592363
Osteoarthritis 153.88 10.07 2474 785450 193256 89647267
Renal impairment 152.33 10.07 442 787482 104979 89735544
Thrombocytopenia 152.08 10.07 1125 786799 207600 89632923
Coma 151.77 10.07 248 787676 72384 89768139
Anaemia 151.38 10.07 2157 785767 350645 89489878
Cognitive disorder 145.96 10.07 236 787688 69171 89771352
Angioedema 145.65 10.07 211 787713 64665 89775858
Sopor 142.20 10.07 22 787902 24622 89815901
Sickle cell anaemia with crisis 141.46 10.07 239 787685 7058 89833465
Intentional product use issue 140.87 10.07 2659 785265 214233 89626290
Chest discomfort 139.84 10.07 672 787252 137693 89702830
Respiratory failure 138.02 10.07 545 787379 117873 89722650
No adverse event 136.63 10.07 238 787686 67744 89772779
Off label use 136.41 10.07 8021 779903 1094231 88746292
Injury 136.38 10.07 2443 785481 194906 89645617
Hypoglycaemia 135.47 10.07 250 787674 69598 89770925
Myalgia 134.81 10.07 929 786995 174196 89666327
Respiratory arrest 132.07 10.07 62 787862 33249 89807274
Syncope 131.93 10.07 648 787276 132015 89708508
Drug resistance 131.42 10.07 50 787874 30399 89810124
Pregnancy 130.03 10.07 955 786969 61092 89779431
Neuropathy peripheral 129.98 10.07 680 787244 136290 89704233
Metabolic acidosis 128.04 10.07 178 787746 55498 89785025
Intentional self-injury 126.89 10.07 48 787876 29286 89811237
Neutrophil count decreased 124.21 10.07 273 787651 71259 89769264
Joint range of motion decreased 123.41 10.07 1758 786166 133885 89706638
Intentional product misuse 122.07 10.07 386 787538 89218 89751305
Multiple organ dysfunction syndrome 120.99 10.07 258 787666 68078 89772445
Facet joint syndrome 120.64 10.07 1348 786576 97041 89743482
Hepatic function abnormal 120.02 10.07 135 787789 46153 89794370
General physical health deterioration 119.41 10.07 3983 783941 351132 89489391
Cytokine release syndrome 118.97 10.07 47 787877 27926 89812597
Sinusitis 118.93 10.07 3862 784062 339226 89501297
Cardio-respiratory arrest 117.19 10.07 232 787692 62908 89777615
COVID-19 116.86 10.07 923 787001 167920 89672603
Grip strength decreased 116.55 10.07 1275 786649 91301 89749222
Inflammation 114.75 10.07 2186 785738 176406 89664117
Weight increased 114.60 10.07 4581 783343 413346 89427177
Live birth 114.53 10.07 1121 786803 77986 89762537
Seizure 114.36 10.07 816 787108 151813 89688710
Vision blurred 114.18 10.07 531 787393 109762 89730761
Peripheral swelling 114.17 10.07 4532 783392 408574 89431949
Hyperglycaemia 112.24 10.07 168 787756 50802 89789721
Tachycardia 111.90 10.07 856 787068 156817 89683706
White blood cell count decreased 111.76 10.07 922 787002 166187 89674336
Hepatic failure 110.72 10.07 109 787815 39619 89800904
Sedation complication 110.42 10.07 10 787914 16934 89823589
Fatigue 109.92 10.07 11544 776380 1142479 88698044
Palpitations 109.88 10.07 716 787208 136012 89704511
Orthostatic hypotension 109.54 10.07 121 787803 41706 89798817
Multiple sclerosis relapse 107.97 10.07 180 787744 52125 89788398
Dyspnoea 106.92 10.07 6421 781503 874534 88965989
Blood glucose increased 106.81 10.07 445 787479 94801 89745722
Dry skin 106.06 10.07 400 787524 87673 89752850
Device expulsion 105.19 10.07 120 787804 40766 89799757
Accidental exposure to product 105.08 10.07 128 787796 42238 89798285
Hypoxia 104.98 10.07 303 787621 72096 89768427
Altered state of consciousness 104.57 10.07 73 787851 31459 89809064
Mobility decreased 103.45 10.07 2884 785040 247850 89592673
Rash 102.94 10.07 8143 779781 787957 89052566
Dehydration 102.34 10.07 1138 786786 193309 89647214
Pulmonary fibrosis 99.26 10.07 1397 786527 106106 89734417
Metastases to bone 98.79 10.07 49 787875 25456 89815067
Deep vein thrombosis postoperative 97.95 10.07 994 786930 69815 89770708
Dysphagia 97.46 10.07 574 787350 111704 89728819
Product dose omission issue 97.18 10.07 1868 786056 289819 89550704
Balance disorder 96.62 10.07 474 787450 96606 89743917
Palmar-plantar erythrodysaesthesia syndrome 95.44 10.07 63 787861 27960 89812563
Platelet count decreased 95.13 10.07 748 787176 136221 89704302
Blood pressure systolic abnormal 94.09 10.07 377 787547 19101 89821422
Feeling abnormal 93.95 10.07 964 786960 166271 89674252
Encephalopathy 93.87 10.07 162 787762 46282 89794241
Shock 93.63 10.07 68 787856 28710 89811813
Condition aggravated 93.56 10.07 6189 781735 589356 89251167
Drug withdrawal syndrome 93.28 10.07 68 787856 28655 89811868
Blood pressure diastolic abnormal 93.02 10.07 381 787543 19500 89821023
Hepatocellular injury 92.18 10.07 70 787854 28888 89811635
Dysarthria 92.09 10.07 211 787713 54271 89786252
Lip dry 92.04 10.07 1309 786615 99646 89740877
Infection 91.68 10.07 3936 783988 358158 89482365
Anaphylactic reaction 91.41 10.07 420 787504 87104 89753419
Anaphylactic shock 91.32 10.07 84 787840 31533 89808990
Suicidal ideation 91.17 10.07 332 787592 73523 89767000
Vomiting 91.12 10.07 5771 782153 782522 89058001
Hyperkalaemia 90.50 10.07 277 787647 64687 89775836
Hallucination 89.24 10.07 285 787639 65674 89774849
Temperature regulation disorder 88.87 10.07 11 787913 14568 89825955
Wrong technique in product usage process 88.83 10.07 321 787603 71250 89769273
Creatinine renal clearance decreased 88.56 10.07 27 787897 18872 89821651
Food allergy 88.52 10.07 56 787868 25422 89815101
Sepsis 88.16 10.07 1069 786855 178745 89661778
Skin exfoliation 88.05 10.07 299 787625 67614 89772909
Restlessness 87.45 10.07 109 787815 35611 89804912
Rash erythematous 84.83 10.07 286 787638 64818 89775705
Asthenia 84.25 10.07 3787 784137 529964 89310559
Ejection fraction decreased 84.16 10.07 63 787861 26190 89814333
Cardiac failure congestive 83.84 10.07 508 787416 98186 89742337
Anxiety 82.67 10.07 2055 785869 307717 89532806
Drug dependence 82.26 10.07 80 787844 29247 89811276
Cytomegalovirus infection 81.29 10.07 67 787857 26535 89813988
Mydriasis 80.94 10.07 16 787908 14996 89825527
Ventricular tachycardia 80.89 10.07 58 787866 24650 89815873
Disability assessment scale score increased 80.55 10.07 132 787792 3799 89836724
Blood calcium decreased 80.49 10.07 86 787838 30096 89810427
Diabetic ketoacidosis 80.29 10.07 57 787867 24350 89816173
Obesity 80.03 10.07 1326 786598 104181 89736342
Disturbance in attention 79.98 10.07 182 787742 46927 89793596
Erythema 79.47 10.07 1458 786466 227788 89612735
Leukopenia 79.09 10.07 531 787393 100179 89740344
Autoimmune disorder 77.70 10.07 1014 786910 75730 89764793
C-reactive protein increased 77.50 10.07 2096 785828 179293 89661230
Red blood cell sedimentation rate increased 76.92 10.07 1075 786849 81520 89759003
Abortion spontaneous 76.77 10.07 763 787161 53293 89787230
Joint effusion 76.41 10.07 357 787567 19353 89821170
Cholestasis 75.77 10.07 124 787800 36175 89804348
Foot deformity 75.74 10.07 823 787101 58828 89781695
Wound infection 75.53 10.07 1323 786601 105079 89735444
Product use in unapproved indication 74.90 10.07 2288 785636 333948 89506575
Arthritis 74.53 10.07 1944 785980 165371 89675152
Schizophrenia 74.18 10.07 19 787905 14895 89825628
Metastases to liver 73.61 10.07 85 787839 28722 89811801
Myocardial infarction 73.45 10.07 579 787345 105393 89735130
Flushing 73.34 10.07 459 787465 88032 89752491
Back pain 72.95 10.07 2149 785775 315026 89525497
Neurotoxicity 72.12 10.07 49 787875 21418 89819105
Personality disorder 72.05 10.07 11 787913 12433 89828090
Respiratory depression 71.64 10.07 23 787901 15552 89824971
Blood pressure systolic increased 71.33 10.07 799 787125 57546 89782977
Ascites 70.54 10.07 198 787726 47542 89792981
Cough 69.90 10.07 2563 785361 366399 89474124
Blood pressure fluctuation 69.74 10.07 730 787194 51683 89788840
Sciatica 69.62 10.07 1254 786670 100128 89740395
Blood pressure decreased 69.26 10.07 375 787549 74520 89766003
Gamma-glutamyltransferase increased 69.10 10.07 141 787783 37811 89802712
Drug level increased 68.72 10.07 84 787840 27678 89812845
Acute hepatic failure 68.72 10.07 57 787867 22504 89818019
Hypercholesterolaemia 68.60 10.07 1246 786678 99646 89740877
Hypokalaemia 68.31 10.07 769 787155 130347 89710176
Disorientation 67.39 10.07 180 787744 43934 89796589
Dermatitis atopic 67.03 10.07 63 787861 23409 89817114
Extrapyramidal disorder 66.73 10.07 29 787895 16274 89824249
Osteonecrosis of jaw 66.44 10.07 151 787773 38952 89801571
Blood creatinine increased 66.13 10.07 563 787361 100823 89739700
Device difficult to use 65.89 10.07 35 787889 17490 89823033
Torsade de pointes 65.40 10.07 25 787899 15157 89825366
Breast cancer stage III 65.03 10.07 1064 786860 83383 89757140
Disease recurrence 64.30 10.07 145 787779 37508 89803015
Joint destruction 64.04 10.07 257 787667 13030 89827493
Fluid retention 64.02 10.07 475 787449 87616 89752907
Blood creatine phosphokinase increased 64.01 10.07 124 787800 33899 89806624
Pulmonary embolism 64.00 10.07 778 787146 130042 89710481
Cerebral haemorrhage 63.93 10.07 127 787797 34395 89806128
Blood bilirubin increased 63.70 10.07 181 787743 43289 89797234
Aphasia 63.67 10.07 177 787747 42635 89797888
Unresponsive to stimuli 63.33 10.07 149 787775 37972 89802551
Metastases to central nervous system 63.12 10.07 37 787887 17505 89823018
Adjustment disorder with depressed mood 63.06 10.07 763 787161 55990 89784533
Parkinsonism 62.55 10.07 22 787902 14043 89826480
Dislocation of vertebra 62.43 10.07 753 787171 55215 89785308
Poisoning 62.40 10.07 27 787897 15190 89825333
Loss of consciousness 61.97 10.07 852 787072 139386 89701137
Bursitis 61.96 10.07 1541 786383 130113 89710410
Hemiparesis 61.59 10.07 114 787810 31705 89808818
Foetal exposure during pregnancy 61.22 10.07 607 787317 42368 89798155
Peripheral venous disease 61.19 10.07 1048 786876 82873 89757650
Musculoskeletal pain 61.14 10.07 1935 785989 169316 89671207
Emotional distress 61.14 10.07 143 787781 36519 89804004
Posterior reversible encephalopathy syndrome 60.30 10.07 63 787861 22276 89818247
Juvenile idiopathic arthritis 60.21 10.07 117 787807 3860 89836663
Gait inability 60.19 10.07 1684 786240 144772 89695751
Gastrointestinal disorder 60.02 10.07 2768 785156 253919 89586604
Bone erosion 59.86 10.07 715 787209 52306 89788217
Thrombotic microangiopathy 59.84 10.07 31 787893 15712 89824811
Therapy partial responder 59.69 10.07 62 787862 21981 89818542
Cerebrovascular accident 59.55 10.07 737 787187 122796 89717727
Colitis 59.41 10.07 360 787564 69582 89770941
Withdrawal syndrome 59.15 10.07 65 787859 22459 89818064
Adverse event 59.07 10.07 1387 786537 116031 89724492
Bone pain 58.62 10.07 308 787616 61675 89778848
Exposure via skin contact 58.58 10.07 11 787913 10694 89829829
Hemiplegia 58.26 10.07 34 787890 16126 89824397
Vertigo 57.90 10.07 362 787562 69449 89771074
Akathisia 57.89 10.07 13 787911 11146 89829377
Disseminated intravascular coagulation 57.85 10.07 61 787863 21477 89819046
Chronic kidney disease 57.83 10.07 232 787692 49959 89790564
Mental status changes 57.71 10.07 197 787727 44482 89796041
Polyarthritis 57.49 10.07 313 787611 18037 89822486
Exposure to toxic agent 56.85 10.07 3 787921 7964 89832559
Blood alkaline phosphatase increased 56.82 10.07 220 787704 47859 89792664
Atrial fibrillation 56.81 10.07 818 787106 132793 89707730
Angina pectoris 56.69 10.07 164 787760 38996 89801527
Psychotic disorder 56.03 10.07 117 787807 31113 89809410
Hypomania 56.01 10.07 6 787918 8891 89831632
Dizziness 55.98 10.07 4387 783537 584897 89255626
Skin haemorrhage 55.81 10.07 62 787862 21318 89819205
Nasal polyps 55.80 10.07 13 787911 10867 89829656
Carotid artery thrombosis 55.08 10.07 7 787917 9085 89831438
Dysgeusia 55.00 10.07 252 787672 52308 89788215
Road traffic accident 54.96 10.07 1274 786650 106352 89734171
Pulmonary oedema 54.06 10.07 317 787607 61763 89778760
Polyneuropathy 53.97 10.07 53 787871 19288 89821235
Eating disorder 53.97 10.07 101 787823 27972 89812551
Respiratory distress 53.58 10.07 167 787757 38779 89801744
Aspartate aminotransferase increased 53.51 10.07 604 787320 102333 89738190
Pain in jaw 53.29 10.07 225 787699 47760 89792763
Hypomagnesaemia 53.02 10.07 147 787777 35441 89805082
Basal cell carcinoma 52.72 10.07 482 787442 32907 89807616
Inappropriate antidiuretic hormone secretion 52.66 10.07 55 787869 19450 89821073
Swollen tongue 52.58 10.07 213 787711 45743 89794780
Joint laxity 52.17 10.07 87 787837 2541 89837982
Dyskinesia 52.16 10.07 154 787770 36380 89804143
Proteinuria 52.03 10.07 76 787848 23215 89817308
Hepatotoxicity 51.49 10.07 214 787710 45628 89794895
Ventricular fibrillation 51.42 10.07 29 787895 14015 89826508
Pancreatitis acute 51.39 10.07 128 787796 31987 89808536
Joint stiffness 51.37 10.07 959 786965 77083 89763440
Speech disorder 51.08 10.07 213 787711 45372 89795151
Brain oedema 50.43 10.07 46 787878 17339 89823184
Second primary malignancy 50.14 10.07 14 787910 10364 89830159
Bronchospasm 49.86 10.07 64 787860 20645 89819878
Gestational diabetes 49.67 10.07 203 787721 10379 89830144
Myoclonus 49.59 10.07 56 787868 19112 89821411
Depressed mood 49.51 10.07 246 787678 49976 89790547
Face oedema 49.29 10.07 79 787845 23239 89817284
Arrhythmia 49.19 10.07 195 787729 42137 89798386
Hypothermia 49.13 10.07 38 787886 15537 89824986
Acute respiratory failure 49.05 10.07 199 787725 42719 89797804
Haematotoxicity 48.67 10.07 24 787900 12511 89828012
Headache 48.48 10.07 6668 781256 856078 88984445
Abnormal behaviour 48.45 10.07 76 787848 22552 89817971
Alanine aminotransferase increased 48.40 10.07 730 787194 117608 89722915
Eczema 48.18 10.07 266 787658 52604 89787919
Status epilepticus 47.89 10.07 56 787868 18818 89821705
Diabetes mellitus inadequate control 47.88 10.07 55 787869 18629 89821894
Toxic skin eruption 47.86 10.07 40 787884 15734 89824789
Acute generalised exanthematous pustulosis 47.77 10.07 30 787894 13673 89826850
Sleep disorder 47.25 10.07 2140 785784 195890 89644633
Haemorrhage 47.14 10.07 381 787543 68988 89771535
Stevens-Johnson syndrome 47.07 10.07 117 787807 29259 89811264
Lethargy 47.05 10.07 338 787586 62801 89777722
Prescribed underdose 47.03 10.07 915 787009 74104 89766419
Dystonia 47.03 10.07 46 787878 16773 89823750
Muscle twitching 45.71 10.07 88 787836 24114 89816409
Gastrointestinal haemorrhage 45.56 10.07 533 787391 89715 89750808
Lower limb fracture 45.48 10.07 1013 786911 84000 89756523
Eye pruritus 45.44 10.07 117 787807 28910 89811613
Cytopenia 45.11 10.07 51 787873 17398 89823125
Loss of personal independence in daily activities 44.99 10.07 1524 786400 134581 89705942
Drug tolerance decreased 44.89 10.07 452 787472 31678 89808845
Caesarean section 44.84 10.07 296 787628 18281 89822242
Adjustment disorder 44.78 10.07 14 787910 9628 89830895
Pleural effusion 44.73 10.07 694 787230 111297 89729226
Rebound effect 44.71 10.07 13 787911 9371 89831152
C-reactive protein 44.66 10.07 443 787481 30924 89809599
Illness 44.58 10.07 476 787448 81493 89759030
Aggression 44.49 10.07 104 787820 26564 89813959
Dry mouth 44.35 10.07 1991 785933 182068 89658455
Blood pressure diastolic decreased 44.27 10.07 391 787533 26435 89814088
Muscle spasticity 44.11 10.07 158 787766 35164 89805359
Osteoporosis 43.96 10.07 1125 786799 95406 89745117
Psoriasis 43.80 10.07 1634 786290 146120 89694403
Arterial occlusive disease 43.73 10.07 27 787897 12419 89828104
Rhinitis allergic 43.46 10.07 49 787875 16736 89823787
Multiple drug therapy 43.44 10.07 5 787919 7004 89833519
Affect lability 43.30 10.07 56 787868 18007 89822516
Metastases to lung 43.27 10.07 45 787879 15946 89824577
Transplant rejection 43.02 10.07 29 787895 12729 89827794
Irritability 42.90 10.07 162 787762 35500 89805023
Anti-cyclic citrullinated peptide antibody 41.99 10.07 391 787533 26830 89813693
Lymphocyte count decreased 41.66 10.07 160 787764 34890 89805633
Haemophagocytic lymphohistiocytosis 41.27 10.07 44 787880 15415 89825108
Coagulopathy 41.16 10.07 88 787836 23201 89817322
Cardiogenic shock 41.15 10.07 95 787829 24373 89816150
Premature labour 41.13 10.07 227 787697 13149 89827374
Bronchopulmonary aspergillosis 41.07 10.07 24 787900 11374 89829149
Motor dysfunction 40.79 10.07 65 787859 19165 89821358
Hypothyroidism 40.77 10.07 282 787642 52845 89787678
Myocarditis 40.68 10.07 36 787888 13770 89826753
Injection site reaction 40.44 10.07 1068 786856 91012 89749511
Mania 40.23 10.07 38 787886 14086 89826437
Eosinophilia 40.21 10.07 121 787803 28412 89812111
X-ray abnormal 40.20 10.07 586 787338 44838 89795685
Muscle rigidity 40.17 10.07 39 787885 14270 89826253
Hyperlipidaemia 40.16 10.07 87 787837 22829 89817694
Sinus tachycardia 40.12 10.07 121 787803 28392 89812131
Chills 40.09 10.07 858 787066 131123 89709400
Fall 39.84 10.07 3626 784298 478184 89362339
Tachypnoea 39.79 10.07 78 787846 21231 89819292
Cerebral infarction 39.51 10.07 110 787814 26486 89814037
Atrioventricular block complete 39.30 10.07 18 787906 9793 89830730
Small for dates baby 39.29 10.07 114 787810 4893 89835630
Obstructive airways disorder 39.18 10.07 106 787818 25763 89814760
Forced expiratory volume decreased 39.03 10.07 3 787921 5805 89834718
Laryngitis 38.89 10.07 639 787285 50114 89790409
Nightmare 38.47 10.07 82 787842 21643 89818880
Sensory loss 38.43 10.07 61 787863 18014 89822509
Acute myeloid leukaemia 38.16 10.07 76 787848 20564 89819959
Tardive dyskinesia 38.00 10.07 24 787900 10906 89829617
Hospitalisation 37.97 10.07 836 787088 127264 89713259
Lupus-like syndrome 37.81 10.07 616 787308 48230 89792293
Drug dose omission by device 37.64 10.07 21 787903 10210 89830313
Neck deformity 37.63 10.07 68 787856 2121 89838402
Oedema 37.58 10.07 2115 785809 198180 89642343
Graft versus host disease 37.51 10.07 12 787912 8132 89832391
Asphyxia 37.41 10.07 8 787916 7095 89833428
Disability 37.40 10.07 529 787395 40216 89800307
Nodule 37.08 10.07 375 787549 26311 89814212
Haematoma 36.94 10.07 194 787730 38854 89801669
Pulmonary arterial hypertension 36.94 10.07 111 787813 26076 89814447
Deep vein thrombosis 36.84 10.07 567 787357 91053 89749470
Mental disorder 36.84 10.07 150 787774 32168 89808355
Stress cardiomyopathy 36.80 10.07 37 787887 13318 89827205
Joint dislocation 36.68 10.07 568 787356 44014 89796509
Dyspnoea exertional 36.46 10.07 427 787497 71861 89768662
Clostridium difficile colitis 36.39 10.07 115 787809 26591 89813932
Diabetes mellitus 36.39 10.07 374 787550 64501 89776022
Melaena 36.31 10.07 167 787757 34630 89805893
Paradoxical drug reaction 36.02 10.07 4 787920 5762 89834761
Neuroleptic malignant syndrome 35.98 10.07 47 787877 15049 89825474
Pain in extremity 35.95 10.07 4458 783466 446071 89394452
Tinnitus 35.48 10.07 224 787700 42878 89797645
Tumour lysis syndrome 35.44 10.07 27 787897 11125 89829398
Hallucination, visual 35.44 10.07 94 787830 22998 89817525
Haemorrhage intracranial 35.33 10.07 48 787876 15114 89825409
Paralysis 34.96 10.07 29 787895 11449 89829074
Urinary retention 34.89 10.07 189 787735 37555 89802968
Hypoaesthesia 34.74 10.07 3178 784746 311032 89529491
Tuberculosis 34.68 10.07 207 787717 12342 89828181
Aspergillus infection 34.66 10.07 26 787898 10797 89829726
Jaundice 34.56 10.07 155 787769 32362 89808161
International normalised ratio increased 34.44 10.07 255 787669 47061 89793462
Lupus vulgaris 34.41 10.07 567 787357 44492 89796031
Device use error 34.41 10.07 10 787914 7211 89833312
Onychomycosis 34.20 10.07 485 787439 36891 89803632
Mucosal inflammation 34.08 10.07 328 787596 57297 89783226
Acute graft versus host disease 33.64 10.07 4 787920 5464 89835059
Panic attack 33.54 10.07 117 787807 26248 89814275
Haemoptysis 33.54 10.07 162 787762 33158 89807365
Epistaxis 33.49 10.07 529 787395 84596 89755927
Substance abuse 33.15 10.07 4 787920 5402 89835121
Gangrene 32.89 10.07 38 787886 12838 89827685
Rheumatoid nodule 32.80 10.07 293 787631 19873 89820650
Miosis 32.73 10.07 21 787903 9463 89831060
Lip swelling 32.64 10.07 199 787725 38411 89802112
Hepatic cytolysis 32.48 10.07 148 787776 30768 89809755
Device related infection 32.43 10.07 115 787809 25671 89814852
Product preparation error 32.41 10.07 25 787899 10236 89830287
Wheelchair user 32.40 10.07 144 787780 7641 89832882
Hepatic cirrhosis 32.36 10.07 749 787175 62504 89778019
Circulatory collapse 32.03 10.07 110 787814 24794 89815729
Bradyphrenia 32.02 10.07 13 787911 7599 89832924
Cardiotoxicity 32.02 10.07 31 787893 11358 89829165
Heart rate decreased 31.99 10.07 648 787276 52857 89787666
Exostosis 31.94 10.07 644 787280 52490 89788033
Maternal drugs affecting foetus 31.81 10.07 108 787816 5047 89835476
Lung disorder 31.78 10.07 1601 786323 148282 89692241
Abdominal pain 31.70 10.07 2985 784939 392736 89447787
Epstein-Barr virus infection 31.67 10.07 26 787898 10318 89830205
Multiple-drug resistance 31.56 10.07 14 787910 7762 89832761
Inappropriate schedule of product administration 31.47 10.07 1028 786896 148905 89691618
Erythema multiforme 31.44 10.07 36 787888 12210 89828313
Infusion site pain 31.33 10.07 79 787845 19659 89820864
Retinitis 31.27 10.07 489 787435 37969 89802554
Multiple fractures 31.25 10.07 165 787759 9397 89831126
Ischaemic stroke 31.24 10.07 94 787830 22072 89818451
Swelling face 31.18 10.07 508 787416 80844 89759679
Complication of device removal 31.05 10.07 8 787916 6247 89834276
Sleep apnoea syndrome 31.01 10.07 156 787768 31591 89808932
Pseudomonas infection 30.82 10.07 51 787873 14814 89825709
Skin burning sensation 30.73 10.07 79 787845 19532 89820991
Pericardial effusion 30.54 10.07 191 787733 36642 89803881
Onychomadesis 30.53 10.07 566 787358 45432 89795091
Coordination abnormal 30.50 10.07 90 787834 21266 89819257
Acute graft versus host disease in skin 30.48 10.07 3 787921 4753 89835770
Cardiomyopathy 30.45 10.07 83 787841 20123 89820400
Leukocytosis 30.43 10.07 152 787772 30838 89809685
Maternal exposure before pregnancy 30.37 10.07 184 787740 11029 89829494
Acute respiratory distress syndrome 30.33 10.07 137 787787 28549 89811974
Tenderness 30.18 10.07 362 787562 26506 89814017
Lymphopenia 30.16 10.07 100 787824 22781 89817742
Crying 29.88 10.07 118 787806 25527 89814996
Complication of device insertion 29.81 10.07 28 787896 10408 89830115
Dysuria 29.81 10.07 210 787714 39191 89801332
Ventricular septal defect 29.68 10.07 109 787815 5298 89835225
Rash maculo-papular 29.60 10.07 221 787703 40712 89799811
Nervousness 29.60 10.07 174 787750 33882 89806641
Psychomotor hyperactivity 29.42 10.07 41 787883 12772 89827751
Accidental overdose 29.32 10.07 136 787788 28137 89812386
Product administration error 29.27 10.07 124 787800 26299 89814224
Febrile bone marrow aplasia 29.17 10.07 25 787899 9713 89830810
Genital haemorrhage 29.05 10.07 20 787904 8682 89831841
Product prescribing error 28.95 10.07 149 787775 29996 89810527
Aspiration 28.83 10.07 58 787866 15635 89824888
Drug hypersensitivity 28.75 10.07 3560 784364 460049 89380474
Influenza like illness 28.75 10.07 510 787414 80101 89760422
Jaundice cholestatic 28.63 10.07 27 787897 10016 89830507
Product prescribing issue 28.47 10.07 17 787907 7962 89832561
Fear 28.39 10.07 64 787860 16558 89823965
Device dislocation 28.35 10.07 159 787765 31323 89809200
Ketoacidosis 28.07 10.07 7 787917 5588 89834935
Interstitial lung disease 28.01 10.07 481 787443 75924 89764599
Premature rupture of membranes 27.99 10.07 109 787815 5449 89835074
Pathogen resistance 27.97 10.07 18 787906 8097 89832426
Sinus disorder 27.85 10.07 180 787744 34267 89806256
Infective pulmonary exacerbation of cystic fibrosis 27.73 10.07 29 787895 10250 89830273
Hot flush 27.51 10.07 358 787566 59130 89781393
Pulmonary hypertension 27.33 10.07 237 787687 42286 89798237
Toxic epidermal necrolysis 27.32 10.07 168 787756 32360 89808163
Delusion 27.31 10.07 49 787875 13791 89826732
Pemphigoid 27.25 10.07 23 787901 9003 89831520
Hypophosphataemia 27.20 10.07 55 787869 14799 89825724
Urinary incontinence 27.08 10.07 203 787721 37363 89803160
Hypophagia 26.96 10.07 192 787732 35745 89804778
Eye irritation 26.74 10.07 179 787745 33799 89806724
Vascular device infection 26.70 10.07 39 787885 11913 89828610
Incorrect dose administered 26.70 10.07 504 787420 78426 89762097
Respiratory acidosis 26.65 10.07 19 787905 8100 89832423
Myopathy 26.55 10.07 48 787876 13470 89827053
Dysphonia 26.53 10.07 387 787537 62697 89777826
Immune reconstitution inflammatory syndrome 26.41 10.07 14 787910 7005 89833518
Transaminases increased 26.32 10.07 202 787722 36990 89803533
Heart rate increased 26.15 10.07 764 787160 112138 89728385
Blood pressure diastolic increased 26.10 10.07 197 787727 12709 89827814
Sinus bradycardia 26.02 10.07 69 787855 16883 89823640
Purpura 25.98 10.07 56 787868 14722 89825801
Cytomegalovirus infection reactivation 25.94 10.07 18 787906 7782 89832741
Subarachnoid haemorrhage 25.90 10.07 75 787849 17829 89822694
Dysmorphism 25.73 10.07 64 787860 2504 89838019
Procedural pain 25.63 10.07 177 787747 33183 89807340
Acute chest syndrome 25.51 10.07 40 787884 1108 89839415
Body temperature decreased 25.51 10.07 318 787606 23498 89817025
Anuria 25.35 10.07 57 787867 14761 89825762
Enthesopathy 25.27 10.07 154 787770 9250 89831273
Right ventricular failure 25.27 10.07 84 787840 19121 89821402
Toxic encephalopathy 25.25 10.07 23 787901 8676 89831847
Breast cancer metastatic 25.25 10.07 59 787865 15073 89825450
Blood potassium decreased 25.21 10.07 279 787645 47448 89793075
Eosinophil count increased 25.20 10.07 47 787877 13034 89827489
Hyperbilirubinaemia 25.18 10.07 52 787872 13884 89826639
Graft versus host disease in gastrointestinal tract 25.13 10.07 4 787920 4384 89836139
Smear cervix abnormal 25.10 10.07 72 787852 3070 89837453
Middle insomnia 25.10 10.07 69 787855 16682 89823841
Hypervolaemia 25.07 10.07 174 787750 32583 89807940
Labelled drug-drug interaction medication error 25.02 10.07 56 787868 14526 89825997
Wheezing 24.95 10.07 2399 785525 235681 89604842
Ileus 24.90 10.07 68 787856 16478 89824045
Renal tubular necrosis 24.89 10.07 56 787868 14499 89826024
Bradykinesia 24.87 10.07 14 787910 6774 89833749
Limb deformity 24.76 10.07 86 787838 4066 89836457
Seronegative arthritis 24.75 10.07 255 787669 17979 89822544
Treatment noncompliance 24.39 10.07 310 787614 51417 89789106
Acidosis 24.32 10.07 46 787878 12690 89827833
Paranoia 24.32 10.07 47 787877 12861 89827662
Pulmonary congestion 24.21 10.07 87 787837 19346 89821177
Polyuria 24.20 10.07 31 787893 10009 89830514
Sexual dysfunction 24.13 10.07 6 787918 4798 89835725
Drug effective for unapproved indication 24.12 10.07 20 787904 7898 89832625
Ankylosing spondylitis 24.09 10.07 196 787728 12937 89827586
Device breakage 24.05 10.07 54 787870 13990 89826533
Atrial tachycardia 23.98 10.07 11 787913 5979 89834544
Pallor 23.97 10.07 186 787738 33979 89806544
Mood altered 23.95 10.07 73 787851 17071 89823452
Rales 23.86 10.07 65 787859 15762 89824761
Presyncope 23.82 10.07 170 787754 31635 89808888
Multiple allergies 23.74 10.07 61 787863 15085 89825438
Glomerular filtration rate decreased 23.72 10.07 72 787852 16860 89823663
Latent tuberculosis 23.58 10.07 68 787856 2908 89837615
Maternal exposure timing unspecified 23.56 10.07 299 787625 22184 89818339
Pyrexia 23.54 10.07 5232 782692 655253 89185270
Atrial septal defect 23.51 10.07 137 787787 8097 89832426
Lymphoedema 23.45 10.07 53 787871 13700 89826823
Colitis microscopic 23.40 10.07 38 787886 11121 89829402
Chronic obstructive pulmonary disease 23.28 10.07 477 787447 73352 89767171
Malignant mediastinal neoplasm 23.27 10.07 43 787881 1365 89839158
Pulseless electrical activity 23.21 10.07 26 787898 8906 89831617
Electrocardiogram QRS complex prolonged 23.08 10.07 18 787906 7330 89833193
Systemic inflammatory response syndrome 23.08 10.07 14 787910 6502 89834021
Acute myocardial infarction 23.08 10.07 193 787731 34697 89805826
Bradypnoea 23.04 10.07 6 787918 4652 89835871
Product administered to patient of inappropriate age 23.00 10.07 6 787918 4647 89835876
Cyanosis 23.00 10.07 89 787835 19366 89821157
Dissociation 23.00 10.07 15 787909 6700 89833823
Agranulocytosis 22.98 10.07 194 787730 34808 89805715
Ear infection 22.98 10.07 781 787143 68994 89771529
Complication associated with device 22.97 10.07 89 787835 19360 89821163
Blepharospasm 22.89 10.07 638 787286 54807 89785716
Head injury 22.73 10.07 168 787756 31020 89809503
Acute pulmonary oedema 22.66 10.07 30 787894 9550 89830973
Generalised oedema 22.63 10.07 87 787837 18966 89821557
Breast cancer female 22.54 10.07 61 787863 14825 89825698
Atrioventricular block 22.53 10.07 26 787898 8789 89831734
Pulmonary alveolar haemorrhage 22.52 10.07 12 787912 5986 89834537
Metastases to lymph nodes 22.52 10.07 42 787882 11647 89828876
Oliguria 22.45 10.07 36 787888 10588 89829935
Blood lactic acid increased 22.32 10.07 26 787898 8752 89831771
Drug tolerance 22.19 10.07 246 787678 17670 89822853
Antinuclear antibody positive 22.15 10.07 147 787777 9094 89831429
Bacteraemia 22.11 10.07 109 787815 22191 89818332
Cytomegalovirus viraemia 22.09 10.07 20 787904 7566 89832957
Blood urea increased 22.09 10.07 164 787760 30249 89810274
Skin toxicity 22.08 10.07 16 787908 6763 89833760
Respiration abnormal 22.01 10.07 22 787902 7941 89832582
Rheumatoid lung 21.93 10.07 82 787842 4021 89836502
Glycosylated haemoglobin increased 21.92 10.07 66 787858 15496 89825027
Prescribed overdose 21.77 10.07 1048 786876 96577 89743946
Subdural haematoma 21.76 10.07 73 787851 16572 89823951
Hyperuricaemia 21.70 10.07 16 787908 6703 89833820
Hypernatraemia 21.59 10.07 30 787894 9357 89831166
Insurance issue 21.44 10.07 39 787885 10919 89829604
Product administration interrupted 21.42 10.07 48 787876 12444 89828079
Rotator cuff repair 21.34 10.07 58 787866 2396 89838127
Schizoaffective disorder 21.31 10.07 9 787915 5138 89835385
Product adhesion issue 21.28 10.07 9 787915 5133 89835390
Respiratory tract congestion 21.27 10.07 145 787779 27265 89813258
Finger deformity 21.21 10.07 403 787521 32494 89808029
Therapy interrupted 21.21 10.07 307 787617 49801 89790722
Chronic graft versus host disease 21.12 10.07 5 787919 4134 89836389
Device issue 21.10 10.07 160 787764 29377 89811146
Hepatitis acute 21.08 10.07 39 787885 10848 89829675
Gastroenteritis viral 21.02 10.07 376 787548 29979 89810544
Chronic sinusitis 21.01 10.07 121 787803 23681 89816842
Adenovirus infection 20.95 10.07 7 787917 4615 89835908
Therapeutic response shortened 20.90 10.07 115 787809 22764 89817759
Sneezing 20.78 10.07 163 787761 29706 89810817
Synovial disorder 20.74 10.07 67 787857 3051 89837472
Urinary tract infection 20.70 10.07 2333 785591 303299 89537224
Transplant dysfunction 20.68 10.07 10 787914 5272 89835251
Body height below normal 20.64 10.07 53 787871 2115 89838408
Product storage error 20.61 10.07 98 787826 20143 89820380
Sputum discoloured 20.61 10.07 99 787825 20292 89820231
Localised infection 20.57 10.07 408 787516 33154 89807369
Bone marrow failure 20.52 10.07 180 787744 32041 89808482
Throat tightness 20.46 10.07 161 787763 29323 89811200
Total lung capacity increased 20.44 10.07 9 787915 5012 89835511
Troponin increased 20.43 10.07 54 787870 13227 89827296
Hallucinations, mixed 20.38 10.07 13 787911 5876 89834647
Placental disorder 20.37 10.07 44 787880 1567 89838956
Tenosynovitis stenosans 20.30 10.07 78 787846 3875 89836648
Hallucination, auditory 20.25 10.07 71 787853 15904 89824619
Hyperprolactinaemia 20.21 10.07 11 787913 5422 89835101
Blood glucose decreased 20.20 10.07 120 787804 23309 89817214
Tubulointerstitial nephritis 20.20 10.07 133 787791 25210 89815313
Dementia 20.16 10.07 123 787801 23738 89816785
Synovial fluid analysis 20.07 10.07 62 787862 2756 89837767
Systemic candida 20.02 10.07 9 787915 4950 89835573
Infusion site erythema 19.97 10.07 57 787867 13613 89826910
Acute coronary syndrome 19.83 10.07 40 787884 10773 89829750
Sleep terror 19.82 10.07 7 787917 4457 89836066
Developmental hip dysplasia 19.71 10.07 43 787881 1542 89838981
Paraesthesia oral 19.66 10.07 178 787746 31481 89809042
Abdominal distension 19.65 10.07 931 786993 129670 89710853
Nail operation 19.62 10.07 48 787876 1858 89838665
Immune effector cell-associated neurotoxicity syndrome 19.60 10.07 13 787911 5755 89834768
Blindness 19.42 10.07 143 787781 26425 89814098
Red blood cell sedimentation rate 19.27 10.07 86 787838 4572 89835951
Night sweats 19.21 10.07 1333 786591 127433 89713090
Laryngospasm 19.17 10.07 3 787921 3330 89837193
Device leakage 19.16 10.07 36 787888 9955 89830568
Salivary hypersecretion 19.03 10.07 31 787893 9061 89831462
Impaired gastric emptying 19.01 10.07 53 787871 12756 89827767
Cardiac disorder 18.97 10.07 364 787560 56508 89784015
Klebsiella infection 18.96 10.07 38 787886 10259 89830264
Walking aid user 18.96 10.07 423 787501 35083 89805440
Asthma 18.89 10.07 1830 786094 240330 89600193
Stillbirth 18.82 10.07 120 787804 7323 89833200
Plasma cell myeloma 18.77 10.07 246 787678 40582 89799941
Electrolyte imbalance 18.73 10.07 125 787799 23620 89816903
Bone lesion 18.71 10.07 17 787907 6420 89834103
Renal injury 18.69 10.07 38 787886 10205 89830318
Shock haemorrhagic 18.67 10.07 50 787874 12195 89828328
Neck mass 18.64 10.07 75 787849 3807 89836716
Immune-mediated enterocolitis 18.63 10.07 9 787915 4748 89835775
Hereditary angioedema 18.62 10.07 33 787891 9332 89831191
Blood pressure inadequately controlled 18.62 10.07 16 787908 6208 89834315
Visual acuity reduced 18.59 10.07 123 787801 23287 89817236
Clostridium test positive 18.59 10.07 12 787912 5389 89835134
Loose body in joint 18.55 10.07 39 787885 1363 89839160
Tumour marker increased 18.53 10.07 14 787910 5793 89834730
Foetal anticonvulsant syndrome 18.51 10.07 26 787898 651 89839872
Dyspepsia 18.49 10.07 1981 785943 196179 89644344
Generalised tonic-clonic seizure 18.45 10.07 204 787720 34699 89805824
Spinal stenosis 18.38 10.07 232 787692 17192 89823331
Injection site pruritus 18.34 10.07 605 787319 53229 89787294
Bundle branch block left 18.34 10.07 25 787899 7860 89832663
Diabetes insipidus 18.23 10.07 3 787921 3209 89837314
Lacrimation increased 18.22 10.07 149 787775 26913 89813610
Pre-eclampsia 18.21 10.07 161 787763 10887 89829636
End stage renal disease 18.15 10.07 29 787895 8542 89831981
Hepatitis B reactivation 18.05 10.07 6 787918 3968 89836555
Diplopia 18.03 10.07 161 787763 28553 89811970
Coronary artery disease 17.98 10.07 196 787728 33427 89807096
Haematemesis 17.87 10.07 197 787727 33529 89806994
Postoperative wound infection 17.86 10.07 187 787737 13239 89827284
Affective disorder 17.83 10.07 25 787899 7768 89832755
Nystagmus 17.75 10.07 22 787902 7205 89833318
Cleft lip and palate 17.72 10.07 27 787897 729 89839794
Bundle branch block right 17.59 10.07 13 787911 5440 89835083
Anosmia 17.58 10.07 37 787887 9811 89830712
Blood phosphorus decreased 17.58 10.07 11 787913 5023 89835500
Cholelithiasis 17.53 10.07 336 787588 52170 89788353
Body temperature increased 17.53 10.07 278 787646 44432 89796091
Hyperlactacidaemia 17.50 10.07 7 787917 4129 89836394
Therapy non-responder 17.49 10.07 1398 786526 135306 89705217
Hyperthermia 17.48 10.07 40 787884 10295 89830228
Nail disorder 17.44 10.07 653 787271 58414 89782109
Enterocolitis 17.42 10.07 41 787883 10449 89830074
Haematochezia 17.40 10.07 476 787448 70437 89770086
Blood lactate dehydrogenase increased 17.35 10.07 143 787781 25789 89814734
Euglycaemic diabetic ketoacidosis 17.29 10.07 17 787907 6184 89834339
Pruritus genital 17.29 10.07 9 787915 4549 89835974
Ankle arthroplasty 17.20 10.07 59 787865 2772 89837751
Product dose omission in error 17.16 10.07 106 787818 20397 89820126
Feeding disorder 17.13 10.07 86 787838 17426 89823097
Haemodynamic instability 17.11 10.07 49 787875 11690 89828833
Injection site erythema 17.10 10.07 1033 786891 97469 89743054
Renal disorder 17.08 10.07 229 787695 37630 89802893
Rhinovirus infection 17.03 10.07 16 787908 5947 89834576
Amyloid arthropathy 16.97 10.07 42 787882 1638 89838885
Thrombosis 16.88 10.07 496 787428 72755 89767768
Dermatitis exfoliative 16.84 10.07 14 787910 5522 89835001
Synovial cyst 16.74 10.07 166 787758 11586 89828937
Hypogammaglobulinaemia 16.72 10.07 43 787881 10631 89829892
Ventricular extrasystoles 16.72 10.07 59 787865 13191 89827332
Tenosynovitis 16.69 10.07 197 787727 14370 89826153
Hypoglycaemic coma 16.52 10.07 3 787921 2987 89837536
Anti-neutrophil cytoplasmic antibody positive vasculitis 16.51 10.07 7 787917 3986 89836537
Septic shock 16.49 10.07 582 787342 83578 89756945
Extra dose administered 16.49 10.07 34 787890 9084 89831439
Staphylococcal infection 16.47 10.07 309 787615 48130 89792393
Anhedonia 16.45 10.07 48 787876 11383 89829140
Hepatic necrosis 16.45 10.07 19 787905 6419 89834104
Pharyngeal swelling 16.41 10.07 39 787885 9905 89830618
Potentiating drug interaction 16.40 10.07 15 787909 5647 89834876
Spondylitis 16.36 10.07 192 787732 13986 89826537
Human antichimeric antibody positive 16.33 10.07 43 787881 1743 89838780
Peripheral sensory neuropathy 16.30 10.07 35 787889 9215 89831308
Infusion site swelling 16.30 10.07 50 787874 11670 89828853
Pain of skin 16.30 10.07 78 787846 16004 89824519
Neuralgia 16.30 10.07 185 787739 31315 89809208
Personality change 16.24 10.07 24 787900 7297 89833226
Antibody test positive 16.19 10.07 60 787864 2929 89837594
Infusion site pruritus 16.19 10.07 21 787903 6744 89833779
Type 1 diabetes mellitus 16.14 10.07 11 787913 4801 89835722
Congenital arterial malformation 16.07 10.07 17 787907 314 89840209
Facial paralysis 15.94 10.07 75 787849 15459 89825064
Neutrophilia 15.93 10.07 16 787908 5762 89834761
Trigeminal neuralgia 15.90 10.07 8 787916 4123 89836400
Catheter site pain 15.90 10.07 15 787909 5564 89834959
Polyhydramnios 15.88 10.07 53 787871 2455 89838068
Amylase increased 15.87 10.07 23 787901 7049 89833474
Laryngeal oedema 15.82 10.07 22 787902 6859 89833664
Skin plaque 15.77 10.07 40 787884 9935 89830588
Candida infection 15.73 10.07 205 787719 33852 89806671
Malignant melanoma 15.72 10.07 173 787751 12403 89828120
Blood test abnormal 15.69 10.07 112 787812 20840 89819683
Hyperthyroidism 15.67 10.07 94 787830 18216 89822307
Arthritis infective 15.61 10.07 121 787803 7871 89832652
Hypoalbuminaemia 15.59 10.07 78 787846 15819 89824704
Pseudomonal sepsis 15.58 10.07 9 787915 4293 89836230
Limb reduction defect 15.54 10.07 23 787901 605 89839918
Maternal exposure during delivery 15.49 10.07 7 787917 3839 89836684
Clear cell renal cell carcinoma 15.43 10.07 39 787885 1541 89838982
Multiple sclerosis 15.41 10.07 161 787763 27679 89812844
Unevaluable event 15.38 10.07 361 787563 54487 89786036
Liver disorder 15.33 10.07 1239 786685 120030 89720493
Device malfunction 15.29 10.07 113 787811 20864 89819659
Lymphatic fistula 15.26 10.07 37 787887 1424 89839099
Pneumonitis 15.26 10.07 281 787643 43889 89796634
Femur fracture 15.22 10.07 516 787408 45566 89794957
Rash macular 15.21 10.07 179 787745 30101 89810422
Activated partial thromboplastin time prolonged 15.18 10.07 28 787896 7797 89832726
Cardiac failure acute 15.13 10.07 53 787871 11876 89828647
Product substitution issue 15.13 10.07 93 787831 17915 89822608
Skin lesion 15.10 10.07 231 787693 37134 89803389
Scleritis 15.10 10.07 87 787837 5121 89835402
Joint noise 15.09 10.07 88 787836 5202 89835321
Pneumonia viral 15.05 10.07 34 787890 8789 89831734
Hypertelorism 15.03 10.07 21 787903 523 89840000
Nephropathy toxic 15.03 10.07 58 787866 12630 89827893
Sleep disorder due to a general medical condition 15.02 10.07 286 787638 44452 89796071
Skin papilloma 15.01 10.07 92 787832 5538 89834985
Dermatitis acneiform 14.92 10.07 20 787904 6334 89834189
Macular degeneration 14.92 10.07 236 787688 37734 89802789
Device physical property issue 14.88 10.07 3 787921 2773 89837750
Erythema of eyelid 14.83 10.07 5 787919 3278 89837245
Nasal oedema 14.75 10.07 103 787821 6481 89834042
Breast feeding 14.63 10.07 27 787897 856 89839667
Nasal obstruction 14.63 10.07 53 787871 2559 89837964
Hyperammonaemia 14.59 10.07 21 787903 6454 89834069
Bezoar 14.56 10.07 3 787921 2731 89837792
Lung opacity 14.54 10.07 19 787905 6083 89834440
Hyperpyrexia 14.53 10.07 12 787912 4749 89835774
Femoral hernia incarcerated 14.50 10.07 37 787887 1471 89839052
Loss of employment 14.49 10.07 4 787920 2983 89837540
Immune thrombocytopenia 14.48 10.07 63 787861 13263 89827260
Intracranial pressure increased 14.47 10.07 23 787901 6788 89833735
Haematuria 14.46 10.07 215 787709 34722 89805801
Reversible cerebral vasoconstriction syndrome 14.45 10.07 9 787915 4121 89836402
Retrognathia 14.45 10.07 21 787903 543 89839980
Pneumatosis intestinalis 14.25 10.07 6 787918 3431 89837092
Varicella zoster virus infection 14.20 10.07 8 787916 3869 89836654
Dactylitis 14.18 10.07 69 787855 3804 89836719
Pancreatitis 14.11 10.07 481 787443 69345 89771178
Ileus paralytic 14.11 10.07 14 787910 5071 89835452
Restless legs syndrome 14.10 10.07 126 787798 22344 89818179
Pneumothorax 14.09 10.07 103 787821 19064 89821459
Bone density increased 14.08 10.07 27 787897 882 89839641
Malaise 14.06 10.07 4722 783202 581264 89259259
Epstein-Barr virus associated lymphoproliferative disorder 14.05 10.07 3 787921 2664 89837859
Feeling hot 14.04 10.07 545 787379 77463 89763060
Impaired quality of life 14.00 10.07 131 787793 23013 89817510
Blood sodium decreased 13.96 10.07 163 787761 27450 89813073
Wound infection pseudomonas 13.94 10.07 44 787880 1979 89838544
Skin ulcer 13.93 10.07 550 787374 49525 89790998
Kidney transplant rejection 13.91 10.07 13 787911 4844 89835679
Back injury 13.90 10.07 516 787408 46106 89794417
Brain injury 13.87 10.07 29 787895 7709 89832814
Abortion incomplete 13.81 10.07 5 787919 3135 89837388
Hepatitis cholestatic 13.79 10.07 34 787890 8527 89831996
Exercise tolerance decreased 13.79 10.07 28 787896 7523 89833000
Polydipsia 13.76 10.07 10 787914 4221 89836302
Hypokinesia 13.75 10.07 80 787844 15617 89824906
Metastasis 13.73 10.07 20 787904 6117 89834406
Ataxia 13.73 10.07 96 787828 17946 89822577
Haemorrhage in pregnancy 13.68 10.07 46 787878 2139 89838384
Amenorrhoea 13.62 10.07 54 787870 11668 89828855
Pulmonary haemorrhage 13.57 10.07 31 787893 7982 89832541
Mouth ulceration 13.56 10.07 449 787475 39525 89800998
Atrial flutter 13.51 10.07 48 787876 10710 89829813
Incoherent 13.47 10.07 14 787910 4963 89835560
Crohn's disease 13.39 10.07 80 787844 4771 89835752
Speech disorder developmental 13.38 10.07 27 787897 916 89839607
Fracture delayed union 13.32 10.07 50 787874 2456 89838067
Nocardiosis 13.32 10.07 3 787921 2567 89837956
Central nervous system lesion 13.31 10.07 54 787870 11592 89828931
Short stature 13.28 10.07 29 787895 1041 89839482
Hepatitis fulminant 13.26 10.07 9 787915 3936 89836587
Ulcer haemorrhage 13.25 10.07 311 787613 26010 89814513
Full blood count abnormal 13.22 10.07 231 787693 36366 89804157
Hypoventilation 13.13 10.07 16 787908 5280 89835243
Device use issue 13.12 10.07 8 787916 3705 89836818
Skin weeping 13.12 10.07 4 787920 2796 89837727
Neoplasm recurrence 13.02 10.07 6 787918 3253 89837270
Eosinophilic granulomatosis with polyangiitis 13.02 10.07 3 787921 2527 89837996
Iritis 13.02 10.07 65 787859 3621 89836902
Choking 13.00 10.07 57 787867 11976 89828547
Pneumonia bacterial 12.98 10.07 62 787862 12728 89827795
Carotid artery occlusion 12.93 10.07 22 787902 6320 89834203
Cholecystitis chronic 12.91 10.07 43 787881 9783 89830740
Pregnancy with contraceptive device 12.89 10.07 15 787909 5051 89835472
Endophthalmitis 12.89 10.07 13 787911 4672 89835851
Gastroschisis 12.86 10.07 17 787907 401 89840122
Myocardial ischaemia 12.86 10.07 69 787855 13745 89826778
Eyelid oedema 12.86 10.07 54 787870 11480 89829043
Eye swelling 12.80 10.07 179 787745 29207 89811316
Needle issue 12.75 10.07 70 787854 13864 89826659
Thirst 12.74 10.07 86 787838 16209 89824314
Nail injury 12.72 10.07 24 787900 774 89839749
Hepatic encephalopathy 12.71 10.07 69 787855 13703 89826820
Atrioventricular block second degree 12.65 10.07 12 787912 4440 89836083
Inflammatory marker increased 12.57 10.07 129 787795 9085 89831438
Increased appetite 12.55 10.07 56 787868 11709 89828814
Long QT syndrome 12.54 10.07 10 787914 4027 89836496
Anger 12.51 10.07 69 787855 13651 89826872
Lipase increased 12.40 10.07 52 787872 11059 89829464
Congenital anomaly 12.34 10.07 96 787828 6251 89834272
Cystitis haemorrhagic 12.30 10.07 18 787906 5495 89835028
Confusional state 12.26 10.07 3648 784276 382557 89457966
Product availability issue 12.25 10.07 29 787895 7375 89833148
Disturbance in social behaviour 12.24 10.07 11 787913 4177 89836346
Pathological fracture 12.20 10.07 43 787881 9617 89830906
Uterine perforation 12.17 10.07 30 787894 7524 89832999
Product physical issue 12.13 10.07 19 787905 5641 89834882
Cushingoid 12.09 10.07 141 787783 10254 89830269
Dermatitis 12.09 10.07 129 787795 22091 89818432
Skin fissures 12.07 10.07 119 787805 20690 89819833
Osteolysis 12.06 10.07 8 787916 3542 89836981
Dermatitis contact 12.06 10.07 69 787855 13526 89826997
Metastases to peritoneum 12.04 10.07 11 787913 4144 89836379
Device deployment issue 12.00 10.07 15 787909 4894 89835629
Hypercapnia 11.99 10.07 25 787899 6652 89833871
Catheter site erythema 11.91 10.07 15 787909 4879 89835644
Post procedural haemorrhage 11.91 10.07 38 787886 8760 89831763
Hyperreflexia 11.89 10.07 25 787899 6632 89833891
International normalised ratio fluctuation 11.89 10.07 6 787918 3087 89837436
Benign ovarian tumour 11.84 10.07 18 787906 485 89840038
Cross sensitivity reaction 11.82 10.07 5 787919 2852 89837671
Hypotonia 11.82 10.07 55 787869 11371 89829152
Major depression 11.80 10.07 46 787878 9989 89830534
Clostridium difficile infection 11.78 10.07 233 787691 36012 89804511
Metabolic disorder 11.78 10.07 30 787894 7440 89833083
Implant site pain 11.76 10.07 4 787920 2608 89837915
Abnormal dreams 11.76 10.07 54 787870 11203 89829320
Immunosuppressant drug level increased 11.75 10.07 14 787910 4666 89835857
Osteonecrosis 11.74 10.07 159 787765 26082 89814441
Ingrown hair 11.73 10.07 20 787904 595 89839928
Product residue present 11.70 10.07 12 787912 4279 89836244
Cerebral haematoma 11.68 10.07 12 787912 4277 89836246
Bacterial infection 11.62 10.07 139 787785 23305 89817218
Blood loss anaemia 11.60 10.07 47 787877 10093 89830430
Intestinal ischaemia 11.59 10.07 39 787885 8844 89831679
Pancreatic steatosis 11.58 10.07 36 787888 1606 89838917
Congenital cerebral cyst 11.56 10.07 13 787911 258 89840265
Terminal state 11.55 10.07 5 787919 2813 89837710
Oligoarthritis 11.54 10.07 19 787905 549 89839974
Ageusia 11.52 10.07 87 787837 15989 89824534
Lip oedema 11.52 10.07 14 787910 4625 89835898
Exomphalos 11.52 10.07 19 787905 550 89839973
Catheter site haemorrhage 11.50 10.07 9 787915 3659 89836864
Productive cough 11.46 10.07 550 787374 76513 89764010
Ventricular hypokinesia 11.38 10.07 18 787906 5323 89835200
Cleft palate 11.34 10.07 31 787893 1285 89839238
Pneumonia aspiration 11.33 10.07 270 787654 40670 89799853
Inadequate analgesia 11.32 10.07 7 787917 3217 89837306
Upper-airway cough syndrome 11.29 10.07 81 787843 15054 89825469
Intervertebral disc degeneration 11.27 10.07 212 787712 17062 89823461
Pneumonia fungal 11.27 10.07 28 787896 7003 89833520
Heparin-induced thrombocytopenia 11.22 10.07 18 787906 5294 89835229
Decreased appetite 11.21 10.07 3007 784917 373533 89466990
Adverse drug reaction 11.21 10.07 1169 786755 115532 89724991
Cholangitis 11.20 10.07 29 787895 7153 89833370
Hypertransaminasaemia 11.18 10.07 86 787838 15739 89824784
Cardiac failure chronic 11.13 10.07 20 787904 5626 89834897
Learning disorder 11.13 10.07 24 787900 854 89839669
Sickle cell anaemia 11.11 10.07 20 787904 622 89839901
Pulmonary toxicity 11.07 10.07 57 787867 11474 89829049
Human anti-human antibody test 11.06 10.07 16 787908 412 89840111
Total lung capacity decreased 11.06 10.07 10 787914 3785 89836738
Pulmonary tuberculosis 11.05 10.07 76 787848 4758 89835765
Sensitisation 11.02 10.07 12 787912 4163 89836360
Pulmonary function test abnormal 11.01 10.07 5 787919 2734 89837789
Cervical incompetence 10.97 10.07 20 787904 628 89839895
Subacute cutaneous lupus erythematosus 10.97 10.07 9 787915 3573 89836950
Tendonitis 10.91 10.07 253 787671 21119 89819404
Type I hypersensitivity 10.90 10.07 12 787912 4143 89836380
Immune-mediated hepatitis 10.89 10.07 6 787918 2938 89837585
Cyst rupture 10.86 10.07 23 787901 808 89839715
Flatulence 10.85 10.07 275 787649 41092 89799431
Retinal haemorrhage 10.85 10.07 21 787903 5743 89834780
Mental impairment 10.83 10.07 93 787831 16627 89823896
Drug screen positive 10.83 10.07 10 787914 3747 89836776
Intraocular pressure increased 10.79 10.07 29 787895 7064 89833459
Ventricular arrhythmia 10.77 10.07 13 787911 4308 89836215
Foetal distress syndrome 10.77 10.07 36 787888 1669 89838854
Hypocalcaemia 10.76 10.07 283 787641 42085 89798438
Metastases to spine 10.74 10.07 10 787914 3733 89836790
Therapeutic response unexpected 10.74 10.07 130 787794 21750 89818773
Blood potassium increased 10.68 10.07 122 787802 20627 89819896
Cold sweat 10.67 10.07 75 787849 14006 89826517
Immunisation 10.67 10.07 3 787921 2210 89838313
Skin cancer 10.65 10.07 171 787753 13348 89827175
Device occlusion 10.63 10.07 43 787881 9239 89831284
Facial pain 10.60 10.07 69 787855 13113 89827410
Blood parathyroid hormone decreased 10.57 10.07 157 787767 12059 89828464
Respiratory disorder 10.57 10.07 458 787466 64358 89776165
Paranasal sinus discomfort 10.53 10.07 24 787900 6186 89834337
Micturition urgency 10.52 10.07 56 787868 11177 89829346
Colorectal cancer 10.48 10.07 11 787913 3882 89836641
Lymph gland infection 10.48 10.07 18 787906 539 89839984
Neonatal respiratory distress syndrome 10.47 10.07 54 787870 3047 89837476
Skin disorder 10.46 10.07 241 787683 36465 89804058
Wrong product administered 10.45 10.07 33 787891 7632 89832891
Lung transplant 10.44 10.07 10 787914 3682 89836841
Staphylococcal sepsis 10.41 10.07 44 787880 9339 89831184
Haemodialysis 10.35 10.07 40 787884 8707 89831816
Formication 10.35 10.07 16 787908 4775 89835748
Granuloma skin 10.34 10.07 140 787784 10540 89829983
Blood calcium increased 10.27 10.07 62 787862 11996 89828527
Hypoglycaemia neonatal 10.24 10.07 27 787897 1095 89839428
Cell death 10.23 10.07 7 787917 3048 89837475
Hypochloraemia 10.21 10.07 5 787919 2617 89837906
Talipes 10.19 10.07 35 787889 1645 89838878
Embolism 10.19 10.07 45 787879 9436 89831087
Cardiac tamponade 10.19 10.07 21 787903 5611 89834912
Incorrect product administration duration 10.18 10.07 113 787811 19209 89821314
Depressive symptom 10.17 10.07 19 787905 5266 89835257
Pharyngeal oedema 10.12 10.07 74 787850 13697 89826826
Injection site warmth 10.10 10.07 211 787713 17304 89823219
Skin swelling 10.09 10.07 27 787897 6587 89833936
Joint warmth 10.08 10.07 36 787888 1726 89838797

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 649.16 10.21 935 216912 41505 42361983
Drug abuse 353.60 10.21 56 217791 104715 42298773
Foetal exposure during pregnancy 337.93 10.21 747 217100 46564 42356924
Toxicity to various agents 304.60 10.21 437 217410 228699 42174789
Psoriatic arthropathy 265.44 10.21 466 217381 24501 42378987
Arthralgia 251.21 10.21 1852 215995 203386 42200102
Completed suicide 248.66 10.21 91 217756 96374 42307114
Drug interaction 199.73 10.21 698 217149 266301 42137187
Sickle cell anaemia with crisis 152.88 10.21 155 217692 4735 42398753
Psoriasis 151.21 10.21 569 217278 48035 42355453
Joint swelling 145.63 10.21 711 217136 67311 42336177
Dysmorphism 139.75 10.21 124 217723 3192 42400296
Intentional overdose 130.10 10.21 50 217797 51406 42352082
Product use in unapproved indication 113.20 10.21 521 217326 183935 42219553
Arthritis 109.61 10.21 466 217381 41599 42361889
Musculoskeletal stiffness 107.73 10.21 581 217266 57184 42346304
Synovitis 101.30 10.21 237 217610 15330 42388158
Pain 100.62 10.21 1784 216063 243064 42160424
Blood pressure fluctuation 99.09 10.21 333 217514 26575 42376913
Off label use 98.66 10.21 2499 215348 635836 41767652
Premature baby 95.63 10.21 298 217549 22855 42380633
Enthesopathy 94.49 10.21 120 217727 4708 42398780
Small for dates baby 90.89 10.21 123 217724 5140 42398348
Blood pressure systolic increased 89.95 10.21 331 217516 27637 42375851
Coma 85.94 10.21 88 217759 53466 42350022
Acute kidney injury 83.88 10.21 1347 216500 365990 42037498
Exposure during pregnancy 83.73 10.21 154 217693 8394 42395094
Arthropathy 83.48 10.21 336 217511 29261 42374227
Hepatic function abnormal 82.45 10.21 85 217762 51482 42352006
Disease progression 81.00 10.21 418 217429 143238 42260250
Tenosynovitis 79.98 10.21 109 217738 4586 42398902
Death 79.07 10.21 1821 216026 469364 41934124
C-reactive protein abnormal 77.41 10.21 156 217691 9105 42394383
Serotonin syndrome 76.29 10.21 19 217828 25826 42377662
Blood pressure systolic abnormal 76.10 10.21 116 217731 5412 42398076
Rhabdomyolysis 73.34 10.21 183 217664 77836 42325652
Speech disorder developmental 70.65 10.21 72 217775 2213 42401275
Overdose 69.56 10.21 289 217558 104975 42298513
Neonatal respiratory distress syndrome 68.30 10.21 99 217748 4414 42399074
Drug resistance 67.61 10.21 46 217801 34202 42369286
Maternal exposure during pregnancy 66.20 10.21 124 217723 6854 42396634
Sedation 65.61 10.21 37 217810 30438 42373050
Blood pressure diastolic abnormal 64.61 10.21 114 217733 6014 42397474
Drug dependence 63.10 10.21 35 217812 29059 42374429
Foetal anticonvulsant syndrome 63.09 10.21 51 217796 1151 42402337
Low birth weight baby 60.92 10.21 148 217699 9807 42393681
Multiple organ dysfunction syndrome 60.09 10.21 273 217574 96762 42306726
Suicide attempt 59.06 10.21 90 217757 46010 42357478
Intentional product misuse 58.32 10.21 145 217702 61755 42341733
Pancytopenia 58.29 10.21 885 216962 116858 42286630
Weight decreased 57.47 10.21 1430 216417 206518 42196970
Osteoarthritis 57.22 10.21 262 217585 24143 42379345
Hypoglycaemia neonatal 56.27 10.21 62 217785 2088 42401400
Alanine aminotransferase abnormal 56.09 10.21 95 217752 4849 42398639
Nasopharyngitis 55.88 10.21 666 217181 83330 42320158
Pain in extremity 55.71 10.21 1080 216767 149524 42253964
Heart rate decreased 54.82 10.21 347 217500 36185 42367303
Febrile neutropenia 54.04 10.21 648 217199 185055 42218433
Hypospadias 53.62 10.21 78 217769 3489 42399999
Maternal drugs affecting foetus 53.47 10.21 81 217766 3758 42399730
Atrial septal defect 53.10 10.21 122 217725 7797 42395691
Learning disorder 51.70 10.21 44 217803 1069 42402419
Angioedema 50.59 10.21 87 217760 42390 42361098
Peripheral swelling 50.01 10.21 692 217155 89578 42313910
Blood pressure diastolic decreased 48.96 10.21 140 217707 10235 42393253
Cryptorchism 48.86 10.21 56 217791 1971 42401517
Autism spectrum disorder 48.83 10.21 68 217779 2920 42400568
Palmar-plantar erythrodysaesthesia syndrome 48.79 10.21 22 217825 20560 42382928
Drug ineffective for unapproved indication 48.45 10.21 102 217745 46061 42357427
Drug ineffective 48.17 10.21 2684 215163 627513 41775975
Joint effusion 47.70 10.21 98 217749 5799 42397689
Rheumatoid nodule 47.23 10.21 67 217780 2928 42400560
Haemoglobin decreased 45.31 10.21 939 216908 131532 42271956
Poisoning 44.97 10.21 10 217837 14689 42388799
Altered state of consciousness 44.79 10.21 50 217797 29209 42374279
Bradycardia 44.15 10.21 256 217591 85228 42318260
Jaundice neonatal 43.98 10.21 55 217792 2124 42401364
Ventricular septal defect 42.77 10.21 79 217768 4320 42399168
Blood pressure diastolic increased 42.20 10.21 98 217749 6307 42397181
Suicidal ideation 42.17 10.21 117 217730 48044 42355444
Colitis ulcerative 42.02 10.21 253 217594 25922 42377566
No adverse event 41.98 10.21 85 217762 38936 42364552
Cytomegalovirus infection 41.44 10.21 63 217784 32243 42371245
Syndactyly 41.34 10.21 36 217811 903 42402585
Maternal exposure during breast feeding 40.97 10.21 45 217802 1510 42401978
C-reactive protein increased 40.97 10.21 501 217346 63059 42340429
Grip strength decreased 40.78 10.21 69 217778 3519 42399969
Tongue disorder 40.68 10.21 87 217760 5296 42398192
Myelosuppression 40.32 10.21 92 217755 40369 42363119
Depressed level of consciousness 40.20 10.21 119 217728 47851 42355637
Body temperature decreased 40.14 10.21 163 217684 14250 42389238
Drug reaction with eosinophilia and systemic symptoms 40.07 10.21 98 217749 41977 42361511
Haematochezia 40.03 10.21 466 217381 57970 42345518
Inflammation 39.85 10.21 303 217544 33544 42369944
Hand deformity 39.60 10.21 70 217777 3698 42399790
Infusion related reaction 39.06 10.21 479 217368 60327 42343161
Knee arthroplasty 39.04 10.21 116 217731 8665 42394823
Pathogen resistance 38.86 10.21 6 217841 11444 42392044
Foot deformity 38.40 10.21 82 217765 4986 42398502
Neuroleptic malignant syndrome 38.32 10.21 32 217815 21440 42382048
Blood pressure increased 37.67 10.21 731 217116 101197 42302291
Exposure via breast milk 36.99 10.21 54 217793 2423 42401065
Sopor 36.53 10.21 11 217836 13191 42390297
Toxic epidermal necrolysis 36.45 10.21 50 217797 26700 42376788
Joint laxity 35.78 10.21 24 217823 402 42403086
Malignant neoplasm progression 35.56 10.21 368 217479 108032 42295456
Cardiac murmur 35.20 10.21 144 217703 12631 42390857
Renal impairment 35.02 10.21 377 217470 109851 42293637
Foetal growth restriction 34.99 10.21 81 217766 5202 42398286
Red blood cell sedimentation rate increased 34.93 10.21 121 217726 9803 42393685
Abdominal discomfort 34.31 10.21 558 217289 74697 42328791
Respiratory arrest 34.04 10.21 58 217789 28366 42375122
Lower respiratory tract infection 33.97 10.21 341 217506 40865 42362623
Bradycardia neonatal 33.78 10.21 38 217809 1310 42402178
Drug use disorder 33.77 10.21 6 217841 10327 42393161
Acute hepatic failure 33.60 10.21 23 217824 17050 42386438
Loss of personal independence in daily activities 33.56 10.21 396 217451 49420 42354068
Polyarthritis 33.52 10.21 78 217769 5026 42398462
Developmental delay 33.30 10.21 59 217788 3123 42400365
Anal fissure 33.25 10.21 79 217768 5160 42398328
Pulmonary fibrosis 32.63 10.21 241 217606 26440 42377048
Appendicolith 32.50 10.21 14 217833 13442 42390046
Respiratory disorder neonatal 32.45 10.21 45 217802 1925 42401563
Basal cell carcinoma 32.30 10.21 213 217634 22520 42380968
Cardiac failure 32.15 10.21 370 217477 106486 42297002
Anaphylactic shock 32.00 10.21 44 217803 23473 42380015
Psychotic disorder 31.95 10.21 63 217784 29145 42374343
Lactic acidosis 31.95 10.21 121 217726 45140 42358348
Acute chest syndrome 31.91 10.21 33 217814 1032 42402456
Wound 31.77 10.21 172 217675 16945 42386543
Catarrh 31.44 10.21 84 217763 5902 42397586
Drug withdrawal syndrome neonatal 31.32 10.21 70 217777 4391 42399097
Delirium 31.17 10.21 150 217697 52369 42351119
Cardiogenic shock 30.89 10.21 87 217760 35553 42367935
Tendonitis 30.89 10.21 116 217731 9778 42393710
Hypoglycaemia 30.49 10.21 180 217667 59674 42343814
Neurotoxicity 30.45 10.21 46 217801 23605 42379883
Plagiocephaly 30.45 10.21 25 217822 577 42402911
Caesarean section 30.14 10.21 45 217802 2061 42401427
Cardiac arrest 29.68 10.21 387 217460 108933 42294555
Talipes 29.49 10.21 46 217801 2190 42401298
Substance abuse 29.48 10.21 5 217842 8900 42394588
Finger deformity 29.44 10.21 39 217808 1596 42401892
Hypermobility syndrome 29.41 10.21 20 217827 343 42403145
Agitation 29.38 10.21 200 217647 64114 42339374
Dysgraphia 29.24 10.21 49 217798 2479 42401009
Mucocutaneous ulceration 29.18 10.21 23 217824 500 42402988
Electrocardiogram QT prolonged 29.00 10.21 136 217711 47809 42355679
Immune reconstitution inflammatory syndrome 28.90 10.21 8 217839 10135 42393353
Respiratory failure 28.73 10.21 471 217376 127661 42275827
Congenital hand malformation 28.65 10.21 25 217822 629 42402859
Large for dates baby 28.20 10.21 29 217818 901 42402587
Intentional self-injury 27.95 10.21 22 217825 15180 42388308
Renal failure 27.89 10.21 542 217305 143184 42260304
Aspergillus infection 27.78 10.21 24 217823 15813 42387675
Therapy partial responder 27.70 10.21 37 217810 19984 42383504
Burns second degree 27.55 10.21 81 217766 6015 42397473
Musculoskeletal pain 27.52 10.21 276 217571 33064 42370424
Ankylosing spondylitis 27.47 10.21 89 217758 6967 42396521
Ventricular fibrillation 27.26 10.21 72 217775 30051 42373437
Agitation neonatal 27.17 10.21 35 217812 1393 42402095
Respiratory depression 27.00 10.21 34 217813 18834 42384654
Haematocrit decreased 26.92 10.21 285 217562 34623 42368865
Joint range of motion decreased 26.83 10.21 94 217753 7659 42395829
BK virus infection 26.83 10.21 6 217841 8778 42394710
Shock 26.81 10.21 69 217778 29052 42374436
Akathisia 26.67 10.21 10 217837 10441 42393047
Frequent bowel movements 26.54 10.21 194 217653 21213 42382275
Cytomegalovirus infection reactivation 26.41 10.21 12 217835 11166 42392322
Systemic lupus erythematosus 26.40 10.21 106 217741 9218 42394270
Fatigue 26.36 10.21 2576 215271 433065 41970423
Post transplant lymphoproliferative disorder 26.35 10.21 7 217840 9113 42394375
Hypokalaemia 26.25 10.21 237 217610 71484 42332004
Diaphragmatic disorder 26.17 10.21 32 217815 1207 42402281
Hepatic failure 26.15 10.21 103 217744 37997 42365491
Hyperglycaemia 26.05 10.21 133 217714 45726 42357762
Venoocclusive liver disease 26.05 10.21 10 217837 10292 42393196
Language disorder 26.04 10.21 46 217801 2429 42401059
Mucormycosis 26.02 10.21 3 217844 7140 42396348
Wrong technique in product usage process 25.75 10.21 121 217726 42514 42360974
Tuberculosis 25.61 10.21 111 217736 9988 42393500
Ultrasound antenatal screen 25.59 10.21 22 217825 542 42402946
Therapeutic product effect decreased 25.39 10.21 309 217538 38841 42364647
Hydrops foetalis 25.26 10.21 27 217820 878 42402610
Drug intolerance 24.88 10.21 562 217285 79862 42323626
Cytokine release syndrome 24.81 10.21 130 217717 44397 42359091
Foetal disorder 24.65 10.21 29 217818 1050 42402438
Skin cancer 24.64 10.21 120 217727 11342 42392146
Trisomy 18 24.49 10.21 26 217821 839 42402649
Astigmatism 24.35 10.21 32 217815 1299 42402189
Arthritis infective 24.02 10.21 60 217787 4046 42399442
Somnolence 23.61 10.21 545 217302 140560 42262928
Tachycardia 23.51 10.21 369 217478 100718 42302770
Nasal disorder 23.32 10.21 39 217808 1970 42401518
Localised infection 23.21 10.21 181 217666 20192 42383296
Drug withdrawal syndrome 23.13 10.21 47 217800 21502 42381986
Maternal exposure before pregnancy 23.05 10.21 28 217819 1049 42402439
Parosmia 23.04 10.21 89 217758 7602 42395886
Vitamin D deficiency 23.04 10.21 92 217755 7981 42395507
Cleft lip and palate 22.89 10.21 26 217821 906 42402582
Withdrawal syndrome 22.89 10.21 25 217822 14750 42388738
Selective eating disorder 22.86 10.21 36 217811 1728 42401760
Gingival pain 22.81 10.21 95 217752 8399 42395089
Hyperbilirubinaemia neonatal 22.76 10.21 25 217822 839 42402649
Dyspraxia 22.59 10.21 19 217828 454 42403034
Lung neoplasm malignant 22.31 10.21 171 217676 18976 42384512
Anal fistula 22.08 10.21 76 217771 6137 42397351
Radiation inflammation 22.03 10.21 27 217820 1021 42402467
Congenital foot malformation 21.72 10.21 18 217829 421 42403067
Joint stiffness 21.65 10.21 122 217725 12200 42391288
Hypotonia neonatal 21.65 10.21 32 217815 1452 42402036
Suspected suicide 21.62 10.21 3 217844 6196 42397292
Temperature regulation disorder 21.42 10.21 28 217819 1131 42402357
Knee deformity 21.32 10.21 23 217824 756 42402732
Nodule 21.31 10.21 123 217724 12411 42391077
Motor developmental delay 21.25 10.21 22 217825 689 42402799
Serum ferritin increased 21.19 10.21 83 217764 7136 42396352
Crohn's disease 21.15 10.21 47 217800 2937 42400551
Arthrodesis 21.12 10.21 20 217827 561 42402927
Pruritus 21.01 10.21 771 217076 188000 42215488
Proteinuria 20.74 10.21 55 217792 22928 42380560
Acute graft versus host disease 20.73 10.21 8 217839 8207 42395281
Rebound effect 20.69 10.21 6 217841 7373 42396115
Umbilical hernia 20.57 10.21 68 217779 5379 42398109
Aggression 20.34 10.21 137 217710 44026 42359462
Steroid dependence 20.31 10.21 78 217769 6644 42396844
Thymus disorder 20.15 10.21 14 217833 249 42403239
Dyslexia 20.14 10.21 16 217831 352 42403136
Adenovirus infection 20.10 10.21 5 217842 6804 42396684
Metabolic acidosis 20.02 10.21 169 217678 51689 42351799
Oxygen saturation decreased 20.00 10.21 452 217395 64235 42339253
Post procedural infection 19.90 10.21 70 217777 5715 42397773
Transient aphasia 19.77 10.21 20 217827 609 42402879
Ankyloglossia congenital 19.76 10.21 16 217831 362 42403126
Central nervous system mass 19.66 10.21 23 217824 828 42402660
Wall motion score index abnormal 19.57 10.21 23 217824 832 42402656
Hypopnoea 19.51 10.21 86 217761 7796 42395692
Congenital anomaly 19.35 10.21 31 217816 1510 42401978
Exostosis 19.25 10.21 68 217779 5563 42397925
Intellectual disability 19.23 10.21 35 217812 1892 42401596
Ear disorder 19.19 10.21 36 217811 1992 42401496
Cardiac septal defect 19.01 10.21 24 217823 936 42402552
Syringe issue 18.98 10.21 10 217837 8546 42394942
Cellulitis 18.93 10.21 430 217417 61155 42342333
Polyomavirus-associated nephropathy 18.93 10.21 3 217844 5612 42397876
Spinal disorder 18.87 10.21 59 217788 4532 42398956
Appendicitis 18.85 10.21 49 217798 20564 42382924
Cystitis haemorrhagic 18.72 10.21 7 217840 7322 42396166
Airway remodelling 18.62 10.21 23 217824 877 42402611
Red blood cell sedimentation rate 18.28 10.21 25 217822 1055 42402433
Accidental exposure to product 18.25 10.21 49 217798 20344 42383144
Synovial cyst 18.18 10.21 41 217806 2588 42400900
Medical device implantation 18.17 10.21 19 217828 602 42402886
Spina bifida 18.15 10.21 16 217831 408 42403080
Influenza 18.15 10.21 431 217416 61744 42341744
Transfusion-related circulatory overload 18.12 10.21 21 217826 748 42402740
Plantar fasciitis 18.10 10.21 45 217802 3025 42400463
Constipation 18.02 10.21 663 217184 161628 42241860
Drug dose omission by device 18.02 10.21 4 217843 5882 42397606
Blood creatine phosphokinase increased 18.00 10.21 159 217688 48179 42355309
Infection 17.99 10.21 722 217125 111346 42292142
Multiple congenital abnormalities 17.96 10.21 18 217829 542 42402946
Intervertebral disc degeneration 17.95 10.21 80 217767 7287 42396201
Blood parathyroid hormone decreased 17.89 10.21 31 217816 1612 42401876
Cytomegalovirus viraemia 17.87 10.21 16 217831 10361 42393127
Renal aplasia 17.82 10.21 21 217826 762 42402726
Fistula discharge 17.79 10.21 25 217822 1083 42402405
Squamous cell carcinoma of lung 17.67 10.21 37 217810 2219 42401269
Arthritis bacterial 17.66 10.21 68 217779 5800 42397688
Osteonecrosis of jaw 17.64 10.21 45 217802 19004 42384484
Cardiotoxicity 17.58 10.21 8 217839 7437 42396051
Haemolysis 17.56 10.21 96 217751 9493 42393995
Acute graft versus host disease in skin 17.49 10.21 8 217839 7416 42396072
Rhinitis 17.49 10.21 113 217734 11864 42391624
Hepatic steatosis 17.43 10.21 177 217670 21271 42382217
Posterior reversible encephalopathy syndrome 17.43 10.21 24 217823 12797 42390691
Joint ankylosis 17.42 10.21 31 217816 1646 42401842
Sinusitis 17.40 10.21 339 217508 46953 42356535
Ventricular tachycardia 17.40 10.21 87 217760 30073 42373415
Cleft lip 17.39 10.21 14 217833 314 42403174
Limb reduction defect 17.24 10.21 14 217833 318 42403170
Pneumonia aspiration 17.24 10.21 168 217679 49910 42353578
Lacrimal disorder 17.17 10.21 14 217833 320 42403168
Atopy 17.16 10.21 23 217824 952 42402536
Malignant melanoma 17.14 10.21 94 217753 9306 42394182
Congenital bladder anomaly 17.03 10.21 13 217834 269 42403219
Ear infection 17.01 10.21 118 217729 12686 42390802
Anti-cyclic citrullinated peptide antibody positive 16.93 10.21 33 217814 1879 42401609
Weight decrease neonatal 16.91 10.21 14 217833 327 42403161
Alcohol poisoning 16.79 10.21 80 217767 7494 42395994
Oropharyngeal pain 16.77 10.21 308 217539 42202 42361286
Fall 16.76 10.21 1404 216443 233116 42170372
Weight increased 16.71 10.21 693 217154 107290 42296198
Otitis media 16.70 10.21 49 217798 3634 42399854
Haemangioma congenital 16.69 10.21 17 217830 522 42402966
Granuloma skin 16.66 10.21 25 217822 1150 42402338
Pectus excavatum 16.51 10.21 12 217835 230 42403258
Loss of consciousness 16.49 10.21 353 217494 92001 42311487
Patent ductus arteriosus 16.49 10.21 47 217800 3429 42400059
Hypertelorism 16.46 10.21 18 217829 601 42402887
Vitamin B12 deficiency 16.45 10.21 59 217788 4863 42398625
Hydrocele 16.45 10.21 39 217808 2544 42400944
Sexual dysfunction 16.44 10.21 7 217840 6768 42396720
Cerebral haemorrhage 16.42 10.21 124 217723 38842 42364646
Back disorder 16.39 10.21 79 217768 7435 42396053
Device leakage 16.38 10.21 17 217830 10268 42393220
Vomiting 16.35 10.21 1267 216580 288456 42115032
Colorectal cancer 16.30 10.21 3 217844 5035 42398453
Headache 16.16 10.21 1427 216420 237942 42165546
Exposure to toxic agent 16.15 10.21 3 217844 5001 42398487
Upper respiratory tract infection 16.09 10.21 304 217543 41869 42361619
Dermatitis atopic 16.09 10.21 24 217823 12380 42391108
Heart rate irregular 15.82 10.21 138 217709 15912 42387576
Disseminated intravascular coagulation 15.79 10.21 69 217778 24725 42378763
Red blood cell sedimentation rate abnormal 15.49 10.21 49 217798 3787 42399701
Neoplasm progression 15.42 10.21 86 217761 28914 42374574
Asphyxia 15.37 10.21 12 217835 8314 42395174
Myoclonus 15.28 10.21 41 217806 17024 42386464
Neck mass 15.27 10.21 31 217816 1819 42401669
Bone cyst 15.24 10.21 29 217818 1622 42401866
Spondyloarthropathy 15.24 10.21 21 217826 893 42402595
Hypocalcaemia 15.23 10.21 91 217756 30082 42373406
Septic arthritis staphylococcal 15.15 10.21 16 217831 513 42402975
Neutropenia neonatal 15.13 10.21 21 217826 899 42402589
Acute respiratory distress syndrome 15.09 10.21 91 217756 30017 42373471
Immunosuppression 15.06 10.21 84 217763 8369 42395119
Urticaria 15.02 10.21 277 217570 73759 42329729
Chronic graft versus host disease 14.98 10.21 6 217841 6019 42397469
Pulmonary pain 14.92 10.21 28 217819 1550 42401938
Injection site haemorrhage 14.91 10.21 107 217740 11629 42391859
Drug level increased 14.87 10.21 76 217771 26124 42377364
Abortion spontaneous 14.86 10.21 14 217833 390 42403098
Microangiopathy 14.86 10.21 29 217818 1653 42401835
Juvenile idiopathic arthritis 14.85 10.21 38 217809 2601 42400887
Skin injury 14.83 10.21 38 217809 2603 42400885
Obsessive-compulsive disorder 14.78 10.21 8 217839 6735 42396753
Hypertriglyceridaemia 14.75 10.21 18 217829 10108 42393380
Attention deficit hyperactivity disorder 14.72 10.21 42 217805 3066 42400422
Carcinoid tumour of the small bowel 14.71 10.21 14 217833 395 42403093
Red blood cell count decreased 14.69 10.21 242 217605 32473 42371015
Nephropathy toxic 14.67 10.21 41 217806 16797 42386691
Incorrect route of product administration 14.66 10.21 69 217778 24236 42379252
Bursitis 14.61 10.21 67 217780 6177 42397311
Pneumonia 14.58 10.21 2412 215435 419737 41983751
C-reactive protein decreased 14.50 10.21 34 217813 2202 42401286
Oesophageal fibrosis 14.48 10.21 10 217837 176 42403312
Disability assessment scale score increased 14.46 10.21 14 217833 404 42403084
Cytomegalovirus chorioretinitis 14.39 10.21 3 217844 4608 42398880
Polydactyly 14.38 10.21 24 217823 1210 42402278
Hernia pain 14.33 10.21 12 217835 285 42403203
Exposure via skin contact 14.30 10.21 4 217843 5034 42398454
Tooth malformation 14.24 10.21 10 217837 181 42403307
Cholelithiasis 14.17 10.21 182 217665 23164 42380324
Electrocardiogram QRS complex prolonged 14.16 10.21 6 217841 5817 42397671
Contusion 14.13 10.21 297 217550 41688 42361800
Bronchiolitis 14.07 10.21 48 217799 3858 42399630
Gastrointestinal infection 14.07 10.21 70 217777 6673 42396815
Glycosylated haemoglobin increased 14.03 10.21 28 217819 12896 42390592
Low set ears 13.88 10.21 15 217832 494 42402994
Hypertransaminasaemia 13.87 10.21 16 217831 9211 42394277
Dysstasia 13.82 10.21 121 217726 13965 42389523
Ascites 13.82 10.21 205 217642 56473 42347015
Foetal distress syndrome 13.73 10.21 23 217824 1163 42402325
Potentiating drug interaction 13.71 10.21 8 217839 6460 42397028
Rash maculo-papular 13.69 10.21 124 217723 37379 42366109
Mobility decreased 13.64 10.21 255 217592 35051 42368437
Hepatic encephalopathy 13.62 10.21 41 217806 16401 42387087
Endophthalmitis 13.59 10.21 3 217844 4430 42399058
Respiratory rate increased 13.57 10.21 100 217747 10962 42392526
Haematotoxicity 13.54 10.21 22 217825 10963 42392525
Dry throat 13.54 10.21 39 217808 2863 42400625
Blister infected 13.52 10.21 15 217832 509 42402979
Euglycaemic diabetic ketoacidosis 13.49 10.21 6 217841 5654 42397834
Diverticulum 13.47 10.21 75 217772 7466 42396022
Neck pain 13.47 10.21 222 217625 29792 42373696
Autoscopy 13.43 10.21 11 217836 253 42403235
Arnold-Chiari malformation 13.43 10.21 13 217834 375 42403113
Microcephaly 13.43 10.21 20 217827 914 42402574
Mydriasis 13.41 10.21 15 217832 8755 42394733
Maternal exposure timing unspecified 13.37 10.21 13 217834 377 42403111
Melaena 13.33 10.21 130 217717 38616 42364872
Hepatitis E antibody positive 13.32 10.21 11 217836 256 42403232
Respiratory tract infection viral 13.29 10.21 43 217804 3363 42400125
Gangrene neonatal 13.18 10.21 10 217837 205 42403283
Cystitis bacterial 13.14 10.21 10 217837 206 42403282
Hallucination 13.00 10.21 211 217636 57296 42346192
Impaired work ability 13.00 10.21 106 217741 11985 42391503
Multiple-drug resistance 12.96 10.21 11 217836 7311 42396177
Thrombotic microangiopathy 12.87 10.21 36 217811 14746 42388742
Blood phosphorus increased 12.87 10.21 28 217819 12497 42390991
Lung cancer metastatic 12.85 10.21 39 217808 2947 42400541
Diverticular perforation 12.81 10.21 45 217802 3671 42399817
Unresponsive to stimuli 12.73 10.21 101 217746 31302 42372186
Immunodeficiency 12.69 10.21 72 217775 7218 42396270
Lung opacity 12.69 10.21 7 217840 5830 42397658
Scoliosis 12.69 10.21 40 217807 3086 42400402
Haemangioma 12.67 10.21 30 217817 1955 42401533
Psychiatric decompensation 12.66 10.21 3 217844 4219 42399269
Anaemia vitamin B12 deficiency 12.64 10.21 15 217832 548 42402940
Oesophageal adenocarcinoma 12.55 10.21 20 217827 970 42402518
Eosinophilic myocarditis 12.53 10.21 24 217823 1349 42402139
Hyperammonaemia 12.53 10.21 13 217834 7853 42395635
Pleural fibrosis 12.52 10.21 24 217823 1350 42402138
Anal atresia 12.47 10.21 11 217836 281 42403207
Pharyngitis 12.45 10.21 83 217764 8807 42394681
Ligament rupture 12.44 10.21 24 217823 1356 42402132
Developmental coordination disorder 12.43 10.21 10 217837 224 42403264
Bone erosion 12.42 10.21 50 217797 4353 42399135
Fistula 12.39 10.21 76 217771 7836 42395652
Pleuritic pain 12.39 10.21 70 217777 7007 42396481
Strabismus 12.38 10.21 33 217814 2315 42401173
Hepatic enzyme increased 12.35 10.21 314 217533 45470 42358018
Educational problem 12.33 10.21 15 217832 563 42402925
Back pain 12.31 10.21 862 216985 140914 42262574
Foetal heart rate deceleration abnormality 12.31 10.21 15 217832 564 42402924
Asymptomatic bacteriuria 12.28 10.21 10 217837 228 42403260
Lower respiratory tract congestion 12.25 10.21 26 217821 1574 42401914
Disease recurrence 12.24 10.21 95 217752 29583 42373905
Hepatitis fulminant 12.23 10.21 5 217842 4954 42398534
Vascular insufficiency 12.20 10.21 12 217835 353 42403135
Nephrotic syndrome 12.17 10.21 16 217831 8702 42394786
Agranulocytosis 12.16 10.21 99 217748 30513 42372975
Haemodynamic instability 12.15 10.21 29 217818 12528 42390960
Drug-induced liver injury 12.10 10.21 131 217716 38142 42365346
Blood insulin increased 12.09 10.21 12 217835 357 42403131
Tinea pedis 12.06 10.21 30 217817 2018 42401470
Hyponatraemia 12.05 10.21 411 217436 101051 42302437
Gross motor delay 12.04 10.21 12 217835 359 42403129
Pyrexia 12.02 10.21 1799 216048 392243 42011245
Dystonia 12.01 10.21 30 217817 12760 42390728
Hepatitis E virus test positive 11.96 10.21 11 217836 297 42403191
Hypermetropia 11.92 10.21 14 217833 506 42402982
Abdominal adhesions 11.86 10.21 27 217820 1715 42401773
Inguinal hernia 11.76 10.21 82 217765 8830 42394658
Blood test abnormal 11.71 10.21 109 217738 12797 42390691
Abnormal behaviour 11.71 10.21 83 217764 26368 42377120
Psychomotor retardation 11.66 10.21 49 217798 4350 42399138
Nail bed bleeding 11.63 10.21 13 217834 445 42403043
Blood folate increased 11.60 10.21 11 217836 309 42403179
Palindromic rheumatism 11.60 10.21 9 217838 191 42403297
Poor venous access 11.57 10.21 70 217777 7182 42396306
Nerve compression 11.57 10.21 46 217801 3982 42399506
Muscle twitching 11.56 10.21 27 217820 11753 42391735
Vein disorder 11.55 10.21 30 217817 2072 42401416
Latent tuberculosis 11.55 10.21 26 217821 1639 42401849
Mucosal ulceration 11.54 10.21 23 217824 1331 42402157
Blood albumin decreased 11.53 10.21 125 217722 15277 42388211
Rotator cuff syndrome 11.44 10.21 65 217782 6521 42396967
Restlessness 11.43 10.21 95 217752 29154 42374334
Peripheral artery thrombosis 11.40 10.21 35 217812 2662 42400826
Cardio-respiratory arrest 11.39 10.21 221 217626 58415 42345073
Congenital hydronephrosis 11.36 10.21 17 217830 780 42402708
Glomerular filtration rate decreased 11.35 10.21 44 217803 16307 42387181
Infective pulmonary exacerbation of cystic fibrosis 11.28 10.21 14 217833 7804 42395684
Nephrolithiasis 11.27 10.21 257 217590 36573 42366915
Skin abrasion 11.25 10.21 76 217771 8099 42395389
Disinhibition 11.23 10.21 3 217844 3892 42399596
Bronchopulmonary aspergillosis 11.23 10.21 56 217791 19373 42384115
Gamma-glutamyltransferase increased 11.19 10.21 109 217738 32388 42371100
Tender joint count decreased 11.19 10.21 10 217837 260 42403228
Swollen joint count decreased 11.19 10.21 10 217837 260 42403228
Fever neonatal 11.15 10.21 8 217839 150 42403338
Protein deficiency 11.12 10.21 10 217837 262 42403226
Myopia 11.09 10.21 22 217825 1269 42402219
Stress ulcer 11.06 10.21 10 217837 264 42403224
Dehiscence 11.01 10.21 15 217832 631 42402857
Facial pain 11.00 10.21 4 217843 4256 42399232
Coccydynia 10.99 10.21 15 217832 632 42402856
Hepatitis 10.98 10.21 88 217759 27212 42376276
Hallucination, auditory 10.97 10.21 39 217808 14825 42388663
Skin graft failure 10.93 10.21 8 217839 155 42403333
Anal spasm 10.93 10.21 8 217839 155 42403333
Excessive cerumen production 10.93 10.21 11 217836 333 42403155
Panniculitis 10.85 10.21 30 217817 2151 42401337
Congenital genital malformation 10.84 10.21 8 217839 157 42403331
Psychomotor skills impaired 10.84 10.21 54 217793 5150 42398338
Tinnitus 10.83 10.21 208 217639 28730 42374758
Osteochondrosis 10.81 10.21 23 217824 1395 42402093
Palmoplantar pustulosis 10.81 10.21 13 217834 482 42403006
Hyperkalaemia 10.74 10.21 321 217526 80137 42323351
Hand fracture 10.73 10.21 36 217811 2870 42400618
Ear malformation 10.72 10.21 11 217836 341 42403147
Visuospatial deficit 10.71 10.21 7 217840 112 42403376
Hypoxia 10.71 10.21 273 217574 69513 42333975
Brain oedema 10.66 10.21 45 217802 16282 42387206
Vitamin B complex deficiency 10.66 10.21 13 217834 489 42402999
Product quality issue 10.65 10.21 51 217796 17831 42385657
Stevens-Johnson syndrome 10.61 10.21 68 217779 22110 42381378
Kidney infection 10.58 10.21 65 217782 6705 42396783
Necrotising fasciitis streptococcal 10.50 10.21 8 217839 165 42403323
Non-Hodgkin's lymphoma 10.49 10.21 23 217824 1424 42402064
Diabetic ketoacidosis 10.49 10.21 69 217778 22298 42381190
Kyphosis 10.48 10.21 22 217825 1322 42402166
Nail pitting 10.39 10.21 12 217835 426 42403062
Blood homocysteine increased 10.37 10.21 10 217837 287 42403201
Concomitant disease aggravated 10.36 10.21 11 217836 6575 42396913
Fine motor skill dysfunction 10.36 10.21 30 217817 2209 42401279
Mutism 10.33 10.21 23 217824 1439 42402049
Hip arthroplasty 10.32 10.21 54 217793 5251 42398237
Haemoglobinuria 10.31 10.21 15 217832 671 42402817
Fibula fracture 10.30 10.21 20 217827 1136 42402352
PCO2 decreased 10.27 10.21 26 217821 1768 42401720
Emphysema 10.26 10.21 99 217748 11736 42391752
Meningeal disorder 10.26 10.21 11 217836 359 42403129
Mesothelioma 10.23 10.21 12 217835 433 42403055
Bone hypertrophy 10.23 10.21 10 217837 292 42403196
Tumour lysis syndrome 10.21 10.21 69 217778 22162 42381326

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1192.57 10.02 162 792523 242219 109554395
Toxicity to various agents 1191.82 10.02 1016 791669 479539 109317075
Systemic lupus erythematosus 1172.31 10.02 4248 788437 250090 109546524
Arthropathy 1117.55 10.02 4549 788136 282973 109513641
Synovitis 1082.30 10.02 4358 788327 269734 109526880
Pemphigus 1078.45 10.02 3688 788997 210882 109585732
Hand deformity 1057.65 10.02 3709 788976 214797 109581817
Joint swelling 1003.30 10.02 6006 786679 436839 109359775
Glossodynia 973.31 10.02 3649 789036 218355 109578259
Anti-cyclic citrullinated peptide antibody positive 845.25 10.02 3048 789637 178936 109617678
Wound 837.07 10.02 3615 789070 230822 109565792
Rheumatoid arthritis 831.72 10.02 4294 788391 295319 109501295
Drug abuse 810.44 10.02 146 792539 177265 109619349
Pericarditis 808.73 10.02 3413 789272 215701 109580913
Maternal exposure during pregnancy 745.87 10.02 3708 788977 251175 109545439
Drug interaction 745.67 10.02 1541 791144 498642 109297972
Duodenal ulcer perforation 726.27 10.02 2857 789828 174843 109621771
Infusion related reaction 724.10 10.02 4945 787740 376217 109420397
Abdominal discomfort 714.25 10.02 5052 787633 388806 109407808
Arthralgia 706.66 10.02 8612 784073 771020 109025594
Helicobacter infection 686.63 10.02 2853 789832 179024 109617590
Swelling 673.09 10.02 4565 788120 346476 109450138
Alopecia 633.05 10.02 4630 788055 360123 109436491
Psoriatic arthropathy 610.26 10.02 2911 789774 193850 109602764
Therapeutic product effect decreased 606.06 10.02 3396 789289 240920 109555694
Intentional overdose 577.81 10.02 122 792563 132379 109664235
Discomfort 548.84 10.02 3009 789676 211698 109584916
Death 539.78 10.02 2877 789808 695992 109100622
Rheumatoid factor positive 534.11 10.02 2112 790573 129528 109667086
Pain 528.19 10.02 9690 782995 945265 108851349
Contraindicated product administered 522.08 10.02 3305 789380 244962 109551652
Impaired healing 496.13 10.02 2747 789938 193970 109602644
Musculoskeletal stiffness 492.13 10.02 3564 789121 276258 109520356
Febrile neutropenia 484.35 10.02 961 791724 315806 109480808
Acute kidney injury 475.56 10.02 2643 790042 632787 109163827
Hepatic enzyme increased 472.20 10.02 3921 788764 316971 109479643
Folliculitis 444.87 10.02 2374 790311 165279 109631335
Nasopharyngitis 436.36 10.02 4533 788152 389828 109406786
Irritable bowel syndrome 400.63 10.02 2273 790412 161942 109634672
Blister 400.23 10.02 2897 789788 224479 109572135
Muscle injury 397.80 10.02 2029 790656 138778 109657836
C-reactive protein abnormal 393.41 10.02 1907 790778 127788 109668826
Drug intolerance 376.87 10.02 4513 788172 401999 109394615
Fibromyalgia 365.82 10.02 2286 790399 168623 109627991
Lower respiratory tract infection 364.13 10.02 2983 789702 240123 109556491
Rheumatic fever 362.94 10.02 1790 790895 120789 109675825
Sleep disorder due to general medical condition, insomnia type 355.37 10.02 1601 791084 104042 109692572
Exposure during pregnancy 348.16 10.02 2223 790462 165201 109631413
Disease progression 345.54 10.02 773 791912 243261 109553353
Depressed level of consciousness 343.65 10.02 188 792497 112090 109684524
Suicide attempt 332.99 10.02 162 792523 103232 109693382
Cardiac arrest 318.96 10.02 576 792109 196177 109600437
Sinusitis 316.98 10.02 3387 789298 293301 109503313
Peripheral swelling 307.35 10.02 4326 788359 399708 109396906
Ill-defined disorder 304.43 10.02 2047 790638 154806 109641808
Osteoarthritis 304.31 10.02 2297 790388 180326 109616288
Malignant neoplasm progression 302.25 10.02 490 792195 174077 109622537
Type 2 diabetes mellitus 290.14 10.02 2220 790465 175012 109621602
Hypersensitivity 288.79 10.02 4279 788406 399719 109396895
Swollen joint count increased 279.21 10.02 1265 791420 82396 109714218
Stomatitis 276.11 10.02 3058 789627 267184 109529430
Weight increased 272.10 10.02 4372 788313 415272 109381342
Rhabdomyolysis 270.31 10.02 278 792407 120123 109676491
Overdose 270.17 10.02 820 791865 232974 109563640
Sedation 262.29 10.02 86 792599 69597 109727017
Neutropenia 260.67 10.02 1594 791091 373026 109423588
Inflammation 256.13 10.02 2308 790377 190930 109605684
Bradycardia 250.50 10.02 457 792228 155060 109641554
Lactic acidosis 248.80 10.02 181 792504 92630 109703984
Treatment failure 244.60 10.02 3050 789635 274184 109522430
Constipation 244.44 10.02 1531 791154 356255 109440359
Multiple organ dysfunction syndrome 238.88 10.02 452 792233 151258 109645356
Hepatic function abnormal 236.96 10.02 176 792509 89119 109707495
Cardiac failure 232.92 10.02 636 792049 186990 109609624
Contusion 232.57 10.02 2628 790057 230733 109565881
Coma 230.32 10.02 304 792381 117565 109679049
Facet joint syndrome 226.73 10.02 1326 791359 95502 109701112
Hyponatraemia 224.82 10.02 802 791883 216851 109579763
Serotonin syndrome 222.65 10.02 73 792612 59080 109737534
Joint range of motion decreased 221.59 10.02 1565 791120 120267 109676347
Respiratory failure 220.05 10.02 797 791888 214535 109582079
Red blood cell sedimentation rate abnormal 216.80 10.02 517 792168 23992 109772622
Sickle cell anaemia with crisis 216.35 10.02 303 792382 9242 109787372
Renal failure 213.25 10.02 867 791818 225707 109570907
Drug reaction with eosinophilia and systemic symptoms 212.48 10.02 166 792519 81929 109714685
Blood cholesterol increased 210.19 10.02 2137 790548 182648 109613966
Myelosuppression 209.31 10.02 220 792465 94120 109702494
Electrocardiogram QT prolonged 208.86 10.02 285 792400 108675 109687939
Drug resistance 207.95 10.02 72 792613 56302 109740312
Knee arthroplasty 207.78 10.02 970 791715 63978 109732636
Hypotension 204.56 10.02 2588 790097 521261 109275353
Renal impairment 204.33 10.02 680 792005 187765 109608849
Somnolence 204.06 10.02 1271 791414 296178 109500436
Drug ineffective for unapproved indication 203.22 10.02 263 792422 102575 109694039
Grip strength decreased 202.89 10.02 1121 791564 79053 109717561
Arthritis 194.39 10.02 1946 790739 165640 109630974
Pregnancy 194.01 10.02 803 791882 50264 109746350
Hip arthroplasty 184.77 10.02 842 791843 54971 109741643
Lip dry 184.55 10.02 1290 791395 98793 109697821
Product use issue 182.66 10.02 3195 789490 308500 109488114
Blood pressure fluctuation 182.57 10.02 1036 791649 73788 109722826
Blood pressure systolic abnormal 182.01 10.02 488 792197 24362 109772252
Infection 181.92 10.02 3625 789060 358575 109438039
Angioedema 180.49 10.02 266 792419 98234 109698380
Respiratory arrest 179.28 10.02 97 792588 58202 109738412
Mobility decreased 178.66 10.02 2538 790147 234884 109561730
Agitation 175.18 10.02 340 792345 112711 109683903
Intentional product use issue 174.29 10.02 2619 790066 245287 109551327
Blood pressure systolic increased 171.85 10.02 1101 791584 81890 109714724
Hypoglycaemia 171.52 10.02 359 792326 115745 109680869
Injury 170.59 10.02 1983 790702 175282 109621332
Blood pressure diastolic abnormal 170.34 10.02 488 792197 25327 109771287
C-reactive protein increased 166.55 10.02 2336 790349 215583 109581031
Off label use 165.47 10.02 8934 783751 1491251 108305363
Neoplasm progression 165.42 10.02 132 792553 64463 109732151
Musculoskeletal pain 165.40 10.02 2023 790662 181000 109615614
Sopor 164.83 10.02 31 792654 36515 109760099
Bursitis 163.12 10.02 1534 791151 128384 109668230
Live birth 161.65 10.02 950 791735 68534 109728080
Altered state of consciousness 160.24 10.02 108 792577 57518 109739096
Hyperhidrosis 158.41 10.02 746 791939 186552 109610062
Intentional product misuse 155.01 10.02 464 792221 132440 109664174
Red blood cell sedimentation rate increased 154.93 10.02 1027 791658 77275 109719339
Cytokine release syndrome 153.68 10.02 166 792519 70140 109726474
Hepatic failure 150.58 10.02 162 792523 68577 109728037
Sepsis 147.55 10.02 1566 791119 325780 109470834
Cardio-respiratory arrest 146.48 10.02 389 792296 115447 109681167
Cytomegalovirus infection 144.84 10.02 107 792578 54337 109742277
Deep vein thrombosis postoperative 144.03 10.02 820 791865 58471 109738143
Metabolic acidosis 142.69 10.02 314 792371 99430 109697184
Abortion spontaneous 142.16 10.02 554 792131 33728 109762886
Gastrointestinal disorder 138.08 10.02 2470 790215 239482 109557132
Hyperglycaemia 137.92 10.02 249 792436 84841 109711773
Obesity 137.64 10.02 1329 791356 112022 109684592
Thrombocytopenia 136.27 10.02 1723 790962 347162 109449452
Tachycardia 136.19 10.02 1007 791678 225638 109570976
Breast cancer stage III 135.58 10.02 1002 791683 78115 109718499
Wound infection 135.41 10.02 1167 791518 95298 109701316
Liver injury 135.21 10.02 1661 791024 148752 109647862
Sciatica 131.90 10.02 1122 791563 91277 109705337
Drug dependence 129.62 10.02 101 792584 49919 109746695
Peripheral venous disease 128.40 10.02 1037 791648 83080 109713534
Shock 128.07 10.02 117 792568 53471 109743143
Joint effusion 126.30 10.02 383 792302 20522 109776092
Anaphylactic shock 126.24 10.02 110 792575 51436 109745178
Pain in extremity 125.19 10.02 4465 788220 482653 109313961
Intentional self-injury 124.58 10.02 56 792629 37373 109759241
Anaemia 122.23 10.02 2986 789699 544100 109252514
Neuropathy peripheral 121.87 10.02 768 791917 178509 109618105
Respiratory depression 121.30 10.02 39 792646 31962 109764652
Poisoning 120.46 10.02 30 792655 29075 109767539
Product use in unapproved indication 118.16 10.02 2378 790307 444999 109351615
Autoimmune disorder 117.18 10.02 838 791847 64645 109731969
Hyperkalaemia 115.32 10.02 540 792145 135256 109661358
Seizure 115.31 10.02 1021 791664 220164 109576450
Syncope 114.10 10.02 916 791769 201620 109594994
Palmar-plantar erythrodysaesthesia syndrome 113.91 10.02 77 792608 40948 109755666
Hypoxia 112.37 10.02 511 792174 129004 109667610
Condition aggravated 111.03 10.02 6381 786304 728455 109068159
Ventricular tachycardia 110.50 10.02 117 792568 49892 109746722
Neurotoxicity 109.65 10.02 85 792600 42122 109754492
Ventricular fibrillation 108.86 10.02 82 792603 41231 109755383
Drug use disorder 108.29 10.02 5 792680 18069 109778545
Bone erosion 107.86 10.02 634 792051 45737 109750877
Cognitive disorder 106.80 10.02 299 792386 87212 109709402
Road traffic accident 106.68 10.02 1209 791476 106189 109690425
Disability assessment scale score increased 106.53 10.02 142 792543 4128 109792486
Foot deformity 106.48 10.02 653 792032 47827 109748787
Blood pressure diastolic decreased 106.13 10.02 524 792161 35361 109761253
Pulmonary fibrosis 104.67 10.02 1156 791529 100886 109695728
Joint stiffness 104.27 10.02 832 791853 66411 109730203
Disseminated intravascular coagulation 103.68 10.02 86 792599 41200 109755414
Fatigue 103.22 10.02 10083 782602 1205875 108590739
Sedation complication 103.17 10.02 11 792674 19844 109776770
Tremor 103.01 10.02 939 791746 201293 109595321
Neutrophil count decreased 102.65 10.02 481 792204 120460 109676154
Encephalopathy 101.11 10.02 274 792411 80781 109715833
Gait inability 100.98 10.02 1454 791231 134922 109661692
Ascites 100.49 10.02 335 792350 92473 109704141
General physical health deterioration 100.44 10.02 3862 788823 421433 109375181
No adverse event 100.31 10.02 239 792446 73600 109723014
Rash 100.23 10.02 6999 785686 813965 108982649
Suicidal ideation 97.70 10.02 345 792340 93592 109703022
Cardiogenic shock 97.28 10.02 163 792522 57175 109739439
Myalgia 95.30 10.02 1076 791609 221305 109575309
Suspected suicide 95.17 10.02 3 792682 15196 109781418
Nausea 95.09 10.02 7598 785087 1228092 108568522
Cerebral haemorrhage 94.17 10.02 203 792482 64765 109731849
Hypoaesthesia 93.59 10.02 2931 789754 311292 109485322
Mydriasis 93.34 10.02 22 792663 22135 109774479
Hypokalaemia 92.98 10.02 847 791838 181601 109615013
Psoriasis 92.96 10.02 1465 791220 138528 109658086
Acute hepatic failure 92.78 10.02 75 792610 36393 109760221
Adverse event 92.40 10.02 1189 791496 107620 109688994
Neuroleptic malignant syndrome 91.82 10.02 66 792619 33993 109762621
Injection site reaction 91.79 10.02 1010 791675 88060 109708554
Restlessness 91.74 10.02 164 792521 56095 109740519
Hepatocellular injury 91.56 10.02 138 792547 50504 109746110
Dry mouth 91.37 10.02 1974 790711 197974 109598640
Heart rate decreased 91.15 10.02 951 791734 81805 109714809
Dehydration 91.14 10.02 1431 791254 278080 109518534
Lower limb fracture 90.75 10.02 882 791803 74466 109722148
Enthesopathy 90.33 10.02 244 792441 12234 109784380
Blood creatine phosphokinase increased 89.68 10.02 249 792436 72828 109723786
Leukopenia 89.40 10.02 661 792024 148130 109648484
Orthostatic hypotension 86.41 10.02 219 792466 66030 109730584
Hypercholesterolaemia 86.38 10.02 1014 791671 89823 109706791
Blood creatinine increased 86.00 10.02 866 791819 182023 109614591
Cardiac failure congestive 85.92 10.02 681 792004 150319 109646295
Adjustment disorder with depressed mood 85.85 10.02 574 792111 43309 109753305
Dry skin 85.67 10.02 438 792247 107215 109689399
Osteoporosis 85.61 10.02 979 791706 86173 109710441
Polyarthritis 84.86 10.02 314 792371 18649 109777965
Disturbance in attention 84.74 10.02 200 792485 61795 109734819
Aspergillus infection 84.20 10.02 39 792646 25577 109771037
Dislocation of vertebra 83.81 10.02 569 792116 43152 109753462
Hallucination 82.82 10.02 409 792276 101023 109695591
Vision blurred 82.47 10.02 563 792122 128459 109668155
Wrong technique in product usage process 82.28 10.02 334 792351 87014 109709600
Drug withdrawal syndrome 81.89 10.02 91 792594 37963 109758651
Myoclonus 81.31 10.02 70 792615 32928 109763686
Platelet count decreased 80.54 10.02 1164 791521 229279 109567335
Joint destruction 80.24 10.02 215 792470 10728 109785886
Post transplant lymphoproliferative disorder 80.23 10.02 9 792676 15604 109781010
Rheumatoid nodule 80.13 10.02 323 792362 19973 109776641
Myocardial infarction 80.11 10.02 935 791750 191148 109605466
Juvenile idiopathic arthritis 79.04 10.02 149 792536 5858 109790756
Blood glucose increased 78.93 10.02 590 792095 131906 109664708
Sleep disorder 78.01 10.02 1920 790765 196724 109599890
Chest discomfort 77.73 10.02 833 791852 173015 109623599
Cholestasis 77.57 10.02 222 792463 64296 109732318
Aggression 77.02 10.02 196 792489 59014 109737600
Cerebral infarction 76.79 10.02 160 792525 51678 109744936
Proteinuria 76.34 10.02 105 792580 39913 109756701
Therapy partial responder 76.11 10.02 92 792593 36969 109759645
Accidental exposure to product 76.07 10.02 152 792533 49856 109746758
C-reactive protein 75.98 10.02 423 792262 29908 109766706
Night sweats 75.75 10.02 1366 791319 132617 109663997
Withdrawal syndrome 75.60 10.02 68 792617 31312 109765302
Atrial fibrillation 75.42 10.02 1174 791511 228468 109568146
Thrombotic microangiopathy 75.35 10.02 59 792626 29090 109767524
Venoocclusive liver disease 75.12 10.02 10 792675 15197 109781417
Psychotic disorder 74.79 10.02 158 792527 50779 109745835
Skin exfoliation 72.97 10.02 351 792334 87300 109709314
Disorientation 72.52 10.02 261 792424 70410 109726204
Temperature regulation disorder 72.38 10.02 5 792680 12821 109783793
Ejection fraction decreased 72.37 10.02 113 792572 40767 109755847
Respiratory distress 72.26 10.02 252 792433 68622 109727992
Akathisia 72.07 10.02 17 792668 17096 109779518
Torsade de pointes 71.86 10.02 36 792649 22564 109774050
Posterior reversible encephalopathy syndrome 71.74 10.02 82 792603 33779 109762835
Loss of personal independence in daily activities 71.73 10.02 1491 791194 148529 109648085
Pathogen resistance 71.63 10.02 19 792666 17653 109778961
BK virus infection 71.44 10.02 6 792679 13100 109783514
Dysarthria 71.12 10.02 335 792350 83786 109712828
White blood cell count decreased 70.26 10.02 1188 791497 228202 109568412
Cytomegalovirus infection reactivation 70.10 10.02 22 792663 18311 109778303
Diabetic ketoacidosis 70.03 10.02 121 792564 41937 109754677
Exposure to toxic agent 69.78 10.02 6 792679 12852 109783762
Gamma-glutamyltransferase increased 69.36 10.02 217 792468 61092 109735522
Wheezing 69.32 10.02 2355 790330 252875 109543739
Exostosis 69.28 10.02 565 792120 45391 109751223
Bronchopulmonary aspergillosis 69.24 10.02 67 792618 29796 109766818
Extrapyramidal disorder 69.01 10.02 63 792622 28804 109767810
Lung disorder 68.83 10.02 1734 790951 178313 109618301
Loss of consciousness 68.44 10.02 992 791693 195314 109601300
Disease recurrence 68.16 10.02 216 792469 60568 109736046
Drug level increased 67.60 10.02 151 792534 47568 109749046
Onychomadesis 67.55 10.02 559 792126 45104 109751510
Tenosynovitis 67.40 10.02 263 792422 16020 109780594
Onychomycosis 67.15 10.02 490 792195 38041 109758573
Blood pressure diastolic increased 66.98 10.02 290 792395 18517 109778097
Unresponsive to stimuli 66.52 10.02 234 792451 63556 109733058
Dysphagia 66.26 10.02 742 791943 152858 109643756
Anaphylactic reaction 66.18 10.02 513 792172 113787 109682827
Caesarean section 65.39 10.02 233 792452 13584 109783030
Laryngitis 65.33 10.02 524 792161 41887 109754727
Body temperature decreased 65.11 10.02 471 792214 36464 109760150
Immune reconstitution inflammatory syndrome 64.73 10.02 18 792667 16208 109780406
Creatinine renal clearance decreased 64.62 10.02 38 792647 21777 109774837
Hypothermia 64.56 10.02 56 792629 26246 109770368
Substance abuse 64.51 10.02 7 792678 12456 109784158
Asphyxia 64.23 10.02 12 792673 14203 109782411
Haematotoxicity 63.48 10.02 36 792649 21046 109775568
Abnormal behaviour 63.47 10.02 114 792571 38925 109757689
Acute respiratory distress syndrome 63.26 10.02 184 792501 53014 109743600
Brain oedema 63.02 10.02 78 792607 31020 109765594
Blepharospasm 62.62 10.02 635 792050 54216 109742398
Acute graft versus host disease 62.38 10.02 9 792676 12872 109783742
Joint laxity 61.98 10.02 83 792602 2424 109794190
Melaena 60.40 10.02 270 792415 68487 109728127
Appendicolith 60.36 10.02 14 792671 14241 109782373
Hemiplegia 60.31 10.02 45 792640 22737 109773877
Status epilepticus 60.06 10.02 83 792602 31488 109765126
X-ray abnormal 59.84 10.02 473 792212 37644 109758970
Pulmonary oedema 58.64 10.02 451 792234 100208 109696406
Clostridium difficile colitis 58.43 10.02 143 792542 43635 109752979
Interstitial lung disease 58.18 10.02 678 792007 138656 109657958
Lupus-like syndrome 58.02 10.02 495 792190 40297 109756317
Irritability 57.85 10.02 164 792521 47645 109748969
Oedema 57.66 10.02 1940 790745 208036 109588578
Mucormycosis 57.57 10.02 5 792680 10623 109785991
Dystonia 57.43 10.02 60 792625 25745 109770869
Ear infection 57.32 10.02 695 791990 62037 109734577
Localised infection 56.88 10.02 514 792171 42534 109754080
Aphasia 56.57 10.02 224 792461 58773 109737841
Anti-cyclic citrullinated peptide antibody 56.55 10.02 288 792397 19676 109776938
Rebound effect 56.20 10.02 18 792667 14788 109781826
Miosis 56.18 10.02 45 792640 21938 109774676
Dyspnoea 56.05 10.02 7014 785671 1099858 108696756
Finger deformity 56.05 10.02 418 792267 32674 109763940
Gestational diabetes 56.03 10.02 147 792538 7242 109789372
Arrhythmia 55.96 10.02 282 792403 69293 109727321
Toxic epidermal necrolysis 55.92 10.02 213 792472 56514 109740100
Coagulopathy 55.90 10.02 132 792553 40779 109755835
Retinitis 55.70 10.02 410 792275 31917 109764697
Second primary malignancy 55.64 10.02 30 792655 18038 109778576
Personality disorder 55.57 10.02 12 792673 12825 109783789
Blood bilirubin increased 55.53 10.02 318 792367 75654 109720960
Tachypnoea 55.53 10.02 125 792560 39270 109757344
Exposure via skin contact 55.49 10.02 13 792672 13134 109783480
Nodule 55.17 10.02 412 792273 32219 109764395
Speech disorder 54.55 10.02 241 792444 61328 109735286
Neurologic neglect syndrome 54.35 10.02 3 792682 9295 109787319
Balance disorder 54.34 10.02 553 792132 116007 109680607
Inappropriate antidiuretic hormone secretion 54.01 10.02 100 792585 33751 109762863
Graft versus host disease 53.97 10.02 34 792651 18772 109777842
COVID-19 53.40 10.02 1342 791343 243718 109552896
Basal cell carcinoma 53.08 10.02 527 792158 44743 109751871
Diarrhoea 52.83 10.02 7261 785424 1132244 108664370
Tumour lysis syndrome 52.77 10.02 87 792598 30714 109765900
Transplant rejection 52.59 10.02 59 792626 24508 109772106
Psychomotor hyperactivity 52.46 10.02 41 792644 20236 109776378
Lupus vulgaris 52.39 10.02 419 792266 33464 109763150
Pancreatitis acute 52.15 10.02 238 792447 60036 109736578
Dyskinesia 52.12 10.02 191 792494 51255 109745359
Graft versus host disease in gastrointestinal tract 52.09 10.02 3 792682 8965 109787649
Hepatic cirrhosis 52.04 10.02 726 791959 66900 109729714
Unintentional medical device removal 51.78 10.02 3 792682 8920 109787694
Osteonecrosis of jaw 50.83 10.02 175 792510 47842 109748772
Chronic kidney disease 50.20 10.02 330 792355 75961 109720653
Device difficult to use 49.96 10.02 37 792648 18768 109777846
Cytopenia 49.82 10.02 87 792598 30029 109766585
Dermatitis atopic 49.75 10.02 66 792619 25475 109771139
Haemophagocytic lymphohistiocytosis 49.67 10.02 94 792591 31465 109765149
Nail disorder 49.56 10.02 634 792051 57301 109739313
Drug dose omission by device 49.45 10.02 21 792664 14495 109782119
Septic shock 49.15 10.02 813 791872 156715 109639899
Stevens-Johnson syndrome 48.93 10.02 172 792513 46729 109749885
Haemoptysis 48.81 10.02 305 792380 71049 109725565
Mental status changes 48.72 10.02 332 792353 75790 109720824
Blood calcium decreased 48.70 10.02 116 792569 35729 109760885
Joint dislocation 48.68 10.02 415 792270 33775 109762839
Cytomegalovirus viraemia 48.44 10.02 34 792651 17730 109778884
Hypomagnesaemia 48.38 10.02 245 792440 60125 109736489
Adenovirus infection 48.16 10.02 10 792675 10984 109785630
Face oedema 48.15 10.02 105 792580 33364 109763250
Angina pectoris 48.13 10.02 256 792429 62039 109734575
Lymphocyte count decreased 47.78 10.02 229 792456 57014 109739600
Prescribed overdose 47.77 10.02 888 791797 86693 109709921
Palpitations 47.62 10.02 828 791857 158384 109638230
Rash erythematous 47.50 10.02 367 792318 81465 109715149
Maternal exposure timing unspecified 47.39 10.02 285 792400 20728 109775886
Acute respiratory failure 47.30 10.02 330 792355 74930 109721684
Muscle rigidity 46.91 10.02 62 792623 23969 109772645
Polyomavirus-associated nephropathy 46.86 10.02 3 792682 8198 109788416
Acute graft versus host disease in skin 46.58 10.02 10 792675 10730 109785884
Acute chest syndrome 46.54 10.02 66 792619 2037 109794577
Hallucination, visual 46.36 10.02 138 792547 39467 109757147
Hypophosphataemia 46.19 10.02 106 792579 33076 109763538
Red blood cell sedimentation rate 46.13 10.02 110 792575 5104 109791510
Pleural effusion 46.12 10.02 947 791738 176762 109619852
Carotid artery thrombosis 46.06 10.02 7 792678 9631 109786983
Haemorrhage intracranial 45.85 10.02 86 792599 28883 109767731
Rash maculo-papular 44.92 10.02 329 792356 73893 109722721
Gastrointestinal haemorrhage 44.76 10.02 876 791809 164642 109631972
Muscle twitching 44.67 10.02 92 792593 29843 109766771
Tendonitis 43.91 10.02 329 792356 25754 109770860
Metastases to bone 43.84 10.02 100 792585 31272 109765342
Pneumonia aspiration 43.63 10.02 372 792313 80861 109715753
Urinary retention 43.57 10.02 306 792379 69377 109727237
Hyperbilirubinaemia 43.49 10.02 97 792588 30574 109766040
Metastases to central nervous system 43.39 10.02 60 792625 22757 109773857
Mania 43.37 10.02 51 792634 20745 109775869
Bradyphrenia 43.21 10.02 15 792670 11713 109784901
Acute generalised exanthematous pustulosis 43.20 10.02 55 792630 21609 109775005
Hemiparesis 43.17 10.02 165 792520 43738 109752876
Metastases to liver 43.10 10.02 121 792564 35265 109761349
Wheelchair user 43.06 10.02 139 792546 7703 109788911
Cerebrovascular accident 43.00 10.02 980 791705 180304 109616310
Paradoxical drug reaction 42.86 10.02 9 792676 9808 109786806
Maternal exposure before pregnancy 42.86 10.02 132 792553 7133 109789481
Leukocytosis 42.82 10.02 219 792466 53609 109743005
Drug tolerance decreased 42.82 10.02 341 792344 27199 109769415
Back injury 42.81 10.02 524 792161 46875 109749739
Flushing 42.81 10.02 512 792173 104224 109692390
Erythema multiforme 42.66 10.02 53 792632 21044 109775570
Blood alkaline phosphatase increased 42.65 10.02 315 792370 70620 109725994
Eosinophilia 42.08 10.02 243 792442 57693 109738921
Emotional distress 41.91 10.02 172 792513 44675 109751939
Blood pressure decreased 41.72 10.02 577 792108 114514 109682100
Parkinsonism 41.54 10.02 59 792626 22128 109774486
Vomiting 41.53 10.02 5808 786877 904867 108891747
Injection site erythema 41.48 10.02 925 791760 93251 109703363
Hyperthermia 41.40 10.02 55 792630 21217 109775397
Prescribed underdose 41.36 10.02 677 792008 64497 109732117
Tongue disorder 41.01 10.02 207 792478 14091 109782523
Multiple-drug resistance 40.72 10.02 22 792663 13213 109783401
Bacteraemia 40.60 10.02 161 792524 42229 109754385
Alanine aminotransferase abnormal 40.47 10.02 153 792532 9181 109787433
Haemorrhage 40.45 10.02 530 792155 106162 109690452
Agranulocytosis 40.20 10.02 268 792417 61492 109735122
Bronchospasm 40.18 10.02 99 792586 30140 109766474
Cardiotoxicity 40.16 10.02 37 792648 16844 109779770
Acidosis 40.15 10.02 62 792623 22469 109774145
Sinus tachycardia 40.12 10.02 173 792512 44320 109752294
Ischaemic stroke 39.98 10.02 156 792529 41107 109755507
Pulmonary embolism 39.63 10.02 1202 791483 213272 109583342
Generalised tonic-clonic seizure 39.36 10.02 230 792455 54450 109742164
Toxic skin eruption 39.03 10.02 87 792598 27428 109769186
Hepatotoxicity 38.86 10.02 280 792405 63120 109733494
Premature labour 38.66 10.02 149 792536 9023 109787591
Chronic graft versus host disease 38.65 10.02 10 792675 9447 109787167
Neck deformity 38.54 10.02 57 792628 1829 109794785
Multiple sclerosis relapse 38.51 10.02 207 792478 50033 109746581
Aspartate aminotransferase increased 38.10 10.02 864 791821 159072 109637542
Disability 37.98 10.02 357 792328 29866 109766748
Injection site pruritus 37.72 10.02 546 792139 50712 109745902
Cardiomyopathy 37.68 10.02 119 792566 33406 109763208
Fracture 37.49 10.02 305 792380 24483 109772131
Pseudomonas infection 37.16 10.02 91 792594 27762 109768852
Tardive dyskinesia 37.01 10.02 26 792659 13553 109783061
Premature rupture of membranes 36.96 10.02 94 792591 4543 109792071
Epstein-Barr virus infection 36.93 10.02 48 792637 18690 109777924
Femur fracture 36.93 10.02 484 792201 43985 109752629
Electrocardiogram QRS complex prolonged 36.74 10.02 24 792661 12997 109783617
Fear 36.57 10.02 69 792616 23124 109773490
Skin haemorrhage 36.46 10.02 77 792608 24750 109771864
Haematoma 36.45 10.02 257 792428 58219 109738395
Motor dysfunction 36.42 10.02 75 792610 24331 109772283
Schizophrenia 36.15 10.02 63 792622 21763 109774851
Synovial cyst 36.03 10.02 170 792515 11260 109785354
Acute myocardial infarction 36.00 10.02 405 792280 83372 109713242
Feeling abnormal 35.84 10.02 1003 791682 179708 109616906
Diabetes insipidus 35.83 10.02 3 792682 6567 109790047
Pyrexia 35.72 10.02 5775 786910 892490 108904124
Acute myeloid leukaemia 35.71 10.02 146 792539 37964 109758650
Tenderness 35.64 10.02 345 792340 29092 109767522
Hepatic encephalopathy 35.62 10.02 95 792590 28161 109768453
Ankylosing spondylitis 35.37 10.02 212 792473 15400 109781214
Smear cervix abnormal 35.35 10.02 67 792618 2645 109793969
Haemodynamic instability 35.30 10.02 69 792616 22819 109773795
Ileus 35.30 10.02 108 792577 30621 109765993
Latent tuberculosis 35.29 10.02 84 792601 3893 109792721
Fluid retention 35.19 10.02 470 792215 93837 109702777
Graft versus host disease in skin 35.16 10.02 8 792677 8246 109788368
Diabetes mellitus 35.04 10.02 501 792184 98880 109697734
Myocarditis 34.98 10.02 105 792580 29950 109766664
Potentiating drug interaction 34.89 10.02 20 792665 11623 109784991
Klebsiella infection 34.76 10.02 56 792629 19953 109776661
Subdural haematoma 34.57 10.02 139 792546 36315 109760299
Glomerular filtration rate decreased 34.54 10.02 100 792585 28856 109767758
Nocardiosis 34.52 10.02 6 792679 7480 109789134
Anuria 34.50 10.02 77 792608 24264 109772350
Bone pain 34.20 10.02 300 792385 64833 109731781
Spinal stenosis 34.16 10.02 244 792441 18812 109777802
Device leakage 33.85 10.02 39 792646 16009 109780605
Seronegative arthritis 33.83 10.02 185 792500 12992 109783622
Cystitis haemorrhagic 33.78 10.02 23 792662 12186 109784428
Blood parathyroid hormone decreased 33.76 10.02 184 792501 12905 109783709
Eating disorder 33.66 10.02 111 792574 30747 109765867
Candida infection 33.47 10.02 204 792481 47805 109748809
Cardiac failure acute 33.45 10.02 77 792608 24001 109772613
Shock haemorrhagic 33.31 10.02 93 792592 27154 109769460
Tuberculosis 33.28 10.02 230 792455 17544 109779070
Respiratory acidosis 33.26 10.02 30 792655 13796 109782818
Hyperuricaemia 33.23 10.02 33 792652 14498 109782116
Hypothyroidism 33.09 10.02 348 792337 72551 109724063
Device expulsion 33.09 10.02 112 792573 30779 109765835
Sinus bradycardia 32.89 10.02 105 792580 29378 109767236
Hyperammonaemia 32.79 10.02 30 792655 13702 109782912
Appendicitis 32.73 10.02 100 792585 28364 109768250
Stress cardiomyopathy 32.71 10.02 39 792646 15767 109780847
Oliguria 32.62 10.02 52 792633 18605 109778009
Pulmonary alveolar haemorrhage 32.62 10.02 59 792626 20091 109776523
Scleritis 32.46 10.02 99 792586 5321 109791293
Hepatitis B reactivation 32.39 10.02 7 792678 7477 109789137
Migraine 32.38 10.02 1523 791162 170129 109626485
Polyneuropathy 32.33 10.02 119 792566 31893 109764721
Dissociation 32.33 10.02 15 792670 9827 109786787
Product prescribing error 32.29 10.02 225 792460 51106 109745508
Coronary artery disease 32.23 10.02 343 792342 71347 109725267
Immune effector cell-associated neurotoxicity syndrome 32.19 10.02 35 792650 14747 109781867
Arthritis infective 32.06 10.02 154 792531 10275 109786339
Nephropathy toxic 31.98 10.02 96 792589 27382 109769232
Jaundice 31.93 10.02 271 792414 58965 109737649
Mental disorder 31.90 10.02 156 792529 38635 109757979
Generalised oedema 31.76 10.02 113 792572 30591 109766023
Food allergy 31.76 10.02 59 792626 19889 109776725
Blood lactic acid increased 31.72 10.02 40 792645 15781 109780833
Adjustment disorder 31.70 10.02 19 792666 10776 109785838
Neck mass 31.67 10.02 91 792594 4730 109791884
Pemphigoid 31.63 10.02 58 792627 19649 109776965
Granuloma skin 31.42 10.02 162 792523 11121 109785493
Chills 31.41 10.02 1084 791601 189496 109607118
Jaundice cholestatic 31.36 10.02 35 792650 14573 109782041
Colorectal cancer 31.34 10.02 13 792672 9101 109787513
Rhinitis allergic 31.29 10.02 50 792635 17872 109778742
Pre-eclampsia 31.28 10.02 134 792551 8516 109788098
Sexual dysfunction 31.28 10.02 11 792674 8519 109788095
Forced expiratory volume decreased 31.21 10.02 29 792656 13147 109783467
End stage renal disease 31.20 10.02 67 792618 21406 109775208
Enterocolitis 31.11 10.02 55 792630 18894 109777720
Metastases to lung 31.04 10.02 75 792610 22988 109773626
Limb deformity 30.97 10.02 77 792608 3669 109792945
Hypernatraemia 30.90 10.02 50 792635 17783 109778831
Labelled drug-drug interaction medication error 30.87 10.02 107 792578 29195 109767419
Cardiac failure chronic 30.86 10.02 32 792653 13779 109782835
Antinuclear antibody positive 30.85 10.02 139 792546 9029 109787585
Lethargy 30.83 10.02 478 792207 93098 109703516
Euglycaemic diabetic ketoacidosis 30.71 10.02 23 792662 11600 109785014
Lip swelling 30.46 10.02 225 792460 50442 109746172
Acute coronary syndrome 30.45 10.02 76 792609 23036 109773578
Multiple fractures 30.43 10.02 136 792549 8804 109787810
Colitis ulcerative 30.42 10.02 748 791937 76615 109719999
Cyanosis 30.40 10.02 110 792575 29631 109766983
Febrile bone marrow aplasia 30.23 10.02 49 792636 17416 109779198
Mouth ulceration 30.16 10.02 499 792186 47639 109748975
Glycosylated haemoglobin increased 30.09 10.02 79 792606 23540 109773074
Blood phosphorus increased 30.05 10.02 44 792641 16296 109780318
Liver disorder 29.88 10.02 1276 791409 140967 109655647
Delusion 29.85 10.02 80 792605 23675 109772939
Pulmonary arterial hypertension 29.75 10.02 126 792559 32442 109764172
Device related infection 29.65 10.02 164 792521 39355 109757259
Device use error 29.62 10.02 14 792671 9075 109787539
Premature delivery 29.58 10.02 343 792342 30289 109766325
Rotator cuff repair 29.56 10.02 56 792629 2210 109794404
Hallucination, auditory 29.46 10.02 94 792591 26303 109770311
Hepatitis acute 29.44 10.02 56 792629 18710 109777904
Liver function test increased 29.03 10.02 836 791849 87712 109708902
Pulseless electrical activity 29.02 10.02 47 792638 16710 109779904
Gastroenteritis viral 28.98 10.02 347 792338 30879 109765735
Drug tolerance 28.95 10.02 211 792474 16374 109780240
Infective pulmonary exacerbation of cystic fibrosis 28.94 10.02 38 792647 14733 109781881
Diplopia 28.69 10.02 179 792506 41715 109754899
Malignant mediastinal neoplasm 28.67 10.02 42 792643 1336 109795278
Pulmonary haemorrhage 28.64 10.02 46 792639 16410 109780204
Skin ulcer 28.62 10.02 627 792058 63018 109733596
Atrial tachycardia 28.61 10.02 15 792670 9163 109787451
Hypomania 28.56 10.02 19 792666 10191 109786423
Depressed mood 28.54 10.02 288 792397 60521 109736093
Pruritus genital 28.43 10.02 6 792679 6516 109790098
Synovial disorder 28.31 10.02 65 792620 2942 109793672
Vasoplegia syndrome 28.29 10.02 3 792682 5436 109791178
Multiple drug therapy 28.26 10.02 11 792674 8003 109788611
Cytomegalovirus chorioretinitis 28.26 10.02 8 792677 7120 109789494
Hyperlactacidaemia 28.20 10.02 12 792673 8274 109788340
Joint noise 28.10 10.02 91 792594 5052 109791562
Coordination abnormal 28.04 10.02 90 792595 25138 109771476
Hyperlipidaemia 27.87 10.02 147 792538 35701 109760913
Transaminases increased 27.81 10.02 305 792380 63085 109733529
Neck pain 27.79 10.02 1113 791572 122017 109674597
Myopathy 27.77 10.02 89 792596 24871 109771743
Dermatitis acneiform 27.71 10.02 30 792655 12665 109783949
Endophthalmitis 27.64 10.02 12 792673 8175 109788439
Bronchitis 27.46 10.02 1383 791302 155649 109640965
Lung opacity 27.18 10.02 26 792659 11626 109784988
Sensory loss 27.16 10.02 72 792613 21385 109775229
Hypoalbuminaemia 27.15 10.02 111 792574 28863 109767751
Rheumatoid lung 27.08 10.02 80 792605 4224 109792390
Subarachnoid haemorrhage 27.08 10.02 115 792570 29587 109767027
Panniculitis 27.06 10.02 198 792487 15384 109781230
Hepatitis cholestatic 27.05 10.02 53 792632 17513 109779101
Sleep terror 26.99 10.02 7 792678 6603 109790011
Toxic encephalopathy 26.98 10.02 42 792643 15172 109781442
Bacterial infection 26.93 10.02 206 792479 45830 109750784
Paranoia 26.88 10.02 77 792608 22297 109774317
Paralysis 26.78 10.02 44 792641 15556 109781058
Circulatory collapse 26.78 10.02 189 792496 42804 109753810
Troponin increased 26.68 10.02 116 792569 29650 109766964
Hepatitis fulminant 26.67 10.02 14 792671 8546 109788068
Skin toxicity 26.67 10.02 27 792658 11756 109784858
Pneumatosis intestinalis 26.50 10.02 14 792671 8515 109788099
Synovial fluid analysis 26.40 10.02 59 792626 2622 109793992
Hypocalcaemia 26.16 10.02 321 792364 65045 109731569
Ankle arthroplasty 26.09 10.02 57 792628 2494 109794120
Peripheral sensory neuropathy 25.97 10.02 50 792635 16630 109779984
Blood urea increased 25.91 10.02 260 792425 54697 109741917
Myocardial ischaemia 25.78 10.02 101 792584 26583 109770031
Pulmonary congestion 25.77 10.02 124 792561 30842 109765772
Bladder cancer 25.75 10.02 68 792617 20224 109776390
Pneumonia bacterial 25.63 10.02 99 792586 26162 109770452
Affect lability 25.57 10.02 60 792625 18577 109778037
Diabetes mellitus inadequate control 25.50 10.02 118 792567 29657 109766957
Epistaxis 25.49 10.02 725 791960 129647 109666967
Hyperpyrexia 25.43 10.02 13 792672 8056 109788558
Therapy non-responder 25.40 10.02 1375 791310 155932 109640682
International normalised ratio increased 25.39 10.02 453 792232 86319 109710295
Drug effective for unapproved indication 25.23 10.02 39 792646 14128 109782486
Virologic failure 25.08 10.02 3 792682 4949 109791665
Bone disorder 24.99 10.02 247 792438 20945 109775669
Hypogammaglobulinaemia 24.93 10.02 68 792617 20008 109776606
Pancytopenia 24.92 10.02 1784 790901 207829 109588785
Lymphopenia 24.82 10.02 177 792508 39993 109756621
Dyspepsia 24.75 10.02 1637 791048 189328 109607286
Alanine aminotransferase increased 24.64 10.02 1071 791614 182702 109613912
Tenosynovitis stenosans 24.64 10.02 69 792616 3534 109793080
Immune-mediated enterocolitis 24.62 10.02 22 792663 10163 109786451
Product preparation error 24.54 10.02 25 792660 10854 109785760
Cross sensitivity reaction 24.52 10.02 5 792680 5562 109791052
Myasthenia gravis 24.43 10.02 76 792609 21435 109775179
Anxiety 24.22 10.02 2136 790549 342942 109453672
Atrioventricular block complete 24.21 10.02 69 792616 20013 109776601
Cleft lip and palate 24.14 10.02 28 792657 704 109795910
Ventricular arrhythmia 24.13 10.02 22 792663 10065 109786549
Eye pruritus 24.05 10.02 137 792548 32638 109763976
Right ventricular failure 23.96 10.02 100 792585 25854 109770760
Product prescribing issue 23.87 10.02 34 792651 12738 109783876
Blood lactate dehydrogenase increased 23.81 10.02 203 792482 44131 109752483
Weight decreased 23.74 10.02 3761 788924 464296 109332318
Gangrene 23.73 10.02 51 792634 16290 109780324
Presyncope 23.59 10.02 230 792455 48657 109747957
Loose body in joint 23.57 10.02 39 792646 1381 109795233
Adverse drug reaction 23.55 10.02 953 791732 104606 109692008
Palmoplantar keratoderma 23.39 10.02 5 792680 5382 109791232
Normal newborn 23.34 10.02 250 792435 21646 109774968
Foot fracture 23.32 10.02 283 792402 25263 109771351
Blood pressure increased 23.14 10.02 2152 790533 256221 109540393
Accidental death 23.13 10.02 4 792681 5005 109791609
Renal tubular necrosis 23.12 10.02 126 792559 30349 109766265
Hepatocellular carcinoma 23.10 10.02 22 792663 9858 109786756
Rales 23.04 10.02 95 792590 24644 109771970
Joint injury 23.03 10.02 409 792276 39585 109757029
Haematemesis 23 10.02 292 792393 58816 109737798
Walking aid user 22.99 10.02 278 792407 24797 109771817
Strongyloidiasis 22.98 10.02 4 792681 4982 109791632
Affective disorder 22.98 10.02 28 792657 11213 109785401
Pericardial effusion 22.89 10.02 281 792404 56936 109739678
Nasal polyps 22.88 10.02 37 792648 13163 109783451
Polyuria 22.85 10.02 59 792626 17679 109778935
Product dose omission issue 22.84 10.02 1990 790695 319792 109476822
Product label confusion 22.83 10.02 256 792429 22421 109774193
Skin papilloma 22.79 10.02 104 792581 6792 109789822
COVID-19 pneumonia 22.78 10.02 164 792521 36979 109759635
Respiration abnormal 22.75 10.02 22 792663 9787 109786827
Hypoxic-ischaemic encephalopathy 22.75 10.02 18 792667 8829 109787785
Hydrops foetalis 22.67 10.02 28 792657 753 109795861
Immune-mediated myositis 22.64 10.02 8 792677 6178 109790436
Hypercapnia 22.60 10.02 28 792657 11131 109785483
Spondylitis 22.59 10.02 149 792536 11189 109785425
Frequent bowel movements 22.57 10.02 671 792014 70719 109725895
Blindness 22.56 10.02 160 792525 36199 109760415
Amyloid arthropathy 22.51 10.02 42 792643 1638 109794976
Nasal oedema 22.50 10.02 103 792582 6736 109789878
Exposure via ingestion 22.43 10.02 4 792681 4896 109791718
Product administered to patient of inappropriate age 22.42 10.02 15 792670 8021 109788593
Kidney transplant rejection 22.32 10.02 32 792653 11955 109784659
Postoperative wound infection 22.32 10.02 191 792494 15562 109781052
Acute pulmonary oedema 22.30 10.02 56 792629 16940 109779674
Visual acuity reduced 22.27 10.02 137 792548 32036 109764578
Nail operation 22.26 10.02 42 792643 1652 109794962
Product administration error 22.02 10.02 166 792519 37051 109759563
Gastric haemorrhage 22.02 10.02 51 792634 15864 109780750
Venoocclusive disease 21.93 10.02 9 792676 6341 109790273
Bradykinesia 21.92 10.02 27 792658 10761 109785853
Acute myeloid leukaemia recurrent 21.85 10.02 5 792680 5134 109791480
Atrioventricular block 21.84 10.02 56 792629 16821 109779793
Ketoacidosis 21.84 10.02 24 792661 10063 109786551
Poor venous access 21.67 10.02 270 792415 24252 109772362
Hyperprolactinaemia 21.63 10.02 10 792675 6565 109790049
Ultrasound antenatal screen 21.61 10.02 26 792659 680 109795934
Sputum discoloured 21.50 10.02 115 792570 27830 109768784
Erythema 21.49 10.02 1797 790888 289650 109506964
Human antichimeric antibody positive 21.43 10.02 42 792643 1700 109794914
Pulmonary hypertension 21.41 10.02 273 792412 54947 109741667
Transplant dysfunction 21.34 10.02 17 792668 8311 109788303
Type 1 diabetes mellitus 21.32 10.02 20 792665 9027 109787587
Bacterial sepsis 21.28 10.02 26 792659 10400 109786214
Mucocutaneous ulceration 21.25 10.02 27 792658 748 109795866
Fracture delayed union 21.19 10.02 48 792637 2153 109794461
Acute graft versus host disease in intestine 21.15 10.02 7 792678 5632 109790982
Immunosuppressant drug level increased 21.14 10.02 32 792653 11692 109784922
Pneumothorax 21.06 10.02 157 792528 35128 109761486
Colitis 21.04 10.02 565 792120 101758 109694856
Therapeutic response decreased 20.79 10.02 868 791817 95631 109700983
Renal injury 20.63 10.02 67 792618 18646 109777968
Ulcer haemorrhage 20.59 10.02 250 792435 22321 109774293
Bradypnoea 20.53 10.02 19 792666 8630 109787984
Lipase increased 20.48 10.02 67 792618 18605 109778009
Capillary leak syndrome 20.43 10.02 5 792680 4903 109791711
Systemic inflammatory response syndrome 20.39 10.02 39 792646 13004 109783610
Foot operation 20.36 10.02 105 792580 7208 109789406
Acute lymphocytic leukaemia recurrent 20.32 10.02 8 792677 5779 109790835
Fear of injection 20.18 10.02 121 792564 8790 109787824
Human herpesvirus 6 infection 20.16 10.02 11 792674 6570 109790044
Purpura 20.10 10.02 98 792587 24290 109772324
Plantar fasciitis 19.99 10.02 81 792604 5020 109791594
Amylase increased 19.96 10.02 37 792648 12482 109784132
Vascular stent thrombosis 19.94 10.02 3 792682 4158 109792456
Hypertriglyceridaemia 19.85 10.02 55 792630 16099 109780515
Ventricular extrasystoles 19.83 10.02 89 792596 22552 109774062
Heparin-induced thrombocytopenia 19.82 10.02 32 792653 11392 109785222
Dactylitis 19.82 10.02 70 792615 4063 109792551
Anosmia 19.76 10.02 37 792648 12435 109784179
Epilepsy 19.73 10.02 893 791792 99316 109697298
Hypertransaminasaemia 19.68 10.02 98 792587 24157 109772457
Arterial occlusive disease 19.65 10.02 51 792634 15257 109781357
Dysgeusia 19.65 10.02 368 792317 69617 109726997
Lymphatic fistula 19.57 10.02 37 792648 1458 109795156
Intervertebral disc degeneration 19.52 10.02 207 792478 17878 109778736
Salivary hypersecretion 19.46 10.02 62 792623 17359 109779255
Skin cancer 19.40 10.02 204 792481 17580 109779034
Ingrown hair 19.34 10.02 26 792659 762 109795852
Oesophageal carcinoma 19.33 10.02 33 792652 11491 109785123
Femoral hernia incarcerated 19.32 10.02 37 792648 1472 109795142
Trisomy 18 19.23 10.02 23 792662 598 109796016
Linear IgA disease 19.21 10.02 4 792681 4385 109792229
Systemic candida 19.20 10.02 26 792659 9948 109786666
Pain in jaw 19.11 10.02 255 792430 50922 109745692
Incoherent 19.09 10.02 19 792666 8339 109788275
Breast cancer stage I 19.03 10.02 15 792670 7372 109789242
Hydrocephalus 19.02 10.02 28 792657 10347 109786267
Vascular device infection 18.99 10.02 58 792627 16454 109780160
Laryngospasm 18.96 10.02 5 792680 4663 109791951
Abdominal pain upper 18.94 10.02 2816 789869 346295 109450319
Swelling face 18.92 10.02 510 792175 91811 109704803
Brain injury 18.80 10.02 43 792642 13433 109783181
Haematuria 18.76 10.02 452 792233 82553 109714061
Erectile dysfunction 18.73 10.02 69 792616 18487 109778127
Oropharyngeal pain 18.69 10.02 1166 791519 134110 109662504
Metastasis 18.65 10.02 19 792666 8248 109788366
Psychiatric decompensation 18.61 10.02 9 792676 5756 109790858
Vertigo 18.56 10.02 477 792208 86393 109710221
Congestive cardiomyopathy 18.54 10.02 47 792638 14172 109782442
Body height below normal 18.47 10.02 44 792641 2040 109794574
Ileus paralytic 18.44 10.02 35 792650 11702 109784912
Polyhydramnios 18.43 10.02 42 792643 1891 109794723
Skin burning sensation 18.39 10.02 87 792598 21738 109774876
Foetal exposure during pregnancy 18.36 10.02 104 792581 7401 109789213
Therapy interrupted 18.33 10.02 249 792436 49573 109747041
Hypotonia 18.33 10.02 55 792630 15690 109780924
Wound infection pseudomonas 18.32 10.02 48 792637 2363 109794251
Eosinophil count increased 18.31 10.02 83 792602 20975 109775639
Post procedural infection 18.30 10.02 165 792520 13644 109782970
Hypervolaemia 18.27 10.02 247 792438 49213 109747401
Short stature 18.24 10.02 30 792655 1057 109795557
Depressive symptom 18.24 10.02 20 792665 8394 109788220
Prostatic specific antigen increased 18.21 10.02 39 792646 12472 109784142
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.19 10.02 8 792677 5409 109791205
Polydipsia 18.11 10.02 17 792668 7671 109788943
Immune-mediated hepatitis 18.10 10.02 13 792672 6698 109789916
Breast feeding 18.00 10.02 24 792661 698 109795916
Deep vein thrombosis 17.98 10.02 819 791866 139068 109657546
Hypophagia 17.96 10.02 267 792418 52359 109744255
Sudden death 17.88 10.02 102 792583 24293 109772321
Intracranial pressure increased 17.82 10.02 30 792655 10505 109786109
Disturbance in social behaviour 17.74 10.02 7 792678 5051 109791563
Mucosal inflammation 17.70 10.02 539 792146 95602 109701012
Total lung capacity decreased 17.64 10.02 15 792670 7099 109789515
Varicella zoster virus infection 17.61 10.02 12 792673 6356 109790258
Malignant melanoma 17.61 10.02 192 792493 16699 109779915
Obstructive airways disorder 17.58 10.02 229 792456 45920 109750694
Dyspnoea exertional 17.58 10.02 590 792095 103470 109693144
Hyperthyroidism 17.56 10.02 130 792555 29131 109767483
Methaemoglobinaemia 17.54 10.02 24 792661 9144 109787470
Laryngeal oedema 17.46 10.02 27 792658 9780 109786834
Pulmonary function test abnormal 17.41 10.02 7 792678 4993 109791621
Left ventricular dysfunction 17.35 10.02 98 792587 23395 109773219
Injection site warmth 17.30 10.02 196 792489 17209 109779405
Hypertensive crisis 17.28 10.02 103 792582 24269 109772345
Pulmonary pain 17.28 10.02 90 792595 6203 109790411
Anhedonia 17.17 10.02 55 792630 15373 109781241
Metastases to lymph nodes 17.15 10.02 53 792632 14979 109781635
Porphyria acute 17.13 10.02 208 792477 18572 109778042
Electrolyte imbalance 17.12 10.02 176 792509 36852 109759762
Personality change 17.11 10.02 33 792652 10969 109785645
Cholangitis 16.97 10.02 60 792625 16275 109780339
Neutrophilia 16.94 10.02 30 792655 10299 109786315
Cryptococcosis 16.93 10.02 6 792679 4625 109791989
Complications of transplanted kidney 16.90 10.02 17 792668 7425 109789189
Treatment noncompliance 16.90 10.02 396 792289 72594 109724020
Placental disorder 16.89 10.02 28 792657 993 109795621
Antibody test positive 16.86 10.02 55 792630 3065 109793549
Injection site bruising 16.80 10.02 484 792201 50779 109745835
Eczema 16.80 10.02 392 792293 71901 109724713
Nervous system disorder 16.70 10.02 146 792539 31575 109765039
Asthenia 16.64 10.02 4540 788145 684459 109112155
Anticholinergic syndrome 16.61 10.02 5 792680 4275 109792339
Osteonecrosis 16.59 10.02 158 792527 33583 109763031
Osteopenia 16.51 10.02 237 792448 21972 109774642
Creatinine renal clearance increased 16.51 10.02 3 792682 3622 109792992
Incorrect dose administered 16.49 10.02 592 792093 103049 109693565
Small for dates baby 16.49 10.02 22 792663 640 109795974
Hyperphosphataemia 16.47 10.02 61 792624 16320 109780294
Long QT syndrome 16.47 10.02 16 792669 7102 109789512
Type I hypersensitivity 16.45 10.02 13 792672 6380 109790234
Mood altered 16.42 10.02 88 792597 21287 109775327
Concomitant disease aggravated 16.41 10.02 61 792624 16303 109780311
Ulcer 16.39 10.02 415 792270 42701 109753913
Maternal exposure during breast feeding 16.38 10.02 67 792618 4171 109792443
Tetany 16.37 10.02 3 792682 3601 109793013
Cardiac septal defect 16.36 10.02 27 792658 954 109795660
Syringe issue 16.23 10.02 27 792658 9498 109787116
Colitis microscopic 16.16 10.02 46 792639 13348 109783266
Staphylococcal infection 16.05 10.02 380 792305 69564 109727050
Pseudomonal sepsis 16.02 10.02 25 792660 9021 109787593
Ear pain 15.95 10.02 497 792188 52729 109743885
Chronic obstructive pulmonary disease 15.93 10.02 630 792055 108528 109688086
Diaphragmatic disorder 15.84 10.02 39 792646 1847 109794767
Confusional state 15.83 10.02 3690 788995 464990 109331624
Endodontic procedure 15.81 10.02 54 792631 3082 109793532
Dyslipidaemia 15.70 10.02 60 792625 15905 109780709
Hepatitis B 15.69 10.02 28 792657 9584 109787030
Benign ovarian tumour 15.66 10.02 18 792667 448 109796166
Device occlusion 15.63 10.02 56 792629 15129 109781485
Activated partial thromboplastin time prolonged 15.61 10.02 95 792590 22273 109774341
Cyst 15.61 10.02 184 792501 16312 109780302
Lower respiratory tract congestion 15.61 10.02 72 792613 4724 109791890
Thrombosis 15.46 10.02 629 792056 108033 109688581
Atrial flutter 15.43 10.02 106 792579 24156 109772458
Infection reactivation 15.42 10.02 5 792680 4076 109792538
Stillbirth 15.37 10.02 66 792619 4198 109792416
Foetal distress syndrome 15.36 10.02 21 792664 626 109795988
Panic attack 15.33 10.02 133 792552 28807 109767807
Drug screen positive 15.31 10.02 14 792671 6396 109790218
Herpes zoster 15.31 10.02 936 791749 107443 109689171
Hepatitis C 15.30 10.02 43 792642 12530 109784084
Eyelid oedema 15.24 10.02 57 792628 15205 109781409
Complication of device removal 15.24 10.02 7 792678 4613 109792001
Extra dose administered 15.24 10.02 41 792644 12118 109784496
Compartment syndrome 15.23 10.02 12 792673 5898 109790716
Device loosening 15.17 10.02 24 792661 818 109795796
Dysphonia 15.16 10.02 421 792264 75508 109721106
Metabolic disorder 15.10 10.02 33 792652 10477 109786137
Radiation inflammation 15.06 10.02 27 792658 1021 109795593
Total lung capacity increased 15.01 10.02 9 792676 5103 109791511
Aspiration 15.00 10.02 143 792542 30390 109766224
Catarrh 14.99 10.02 97 792588 7238 109789376
Plasma cell myeloma recurrent 14.98 10.02 17 792668 7025 109789589
Swollen joint count 14.94 10.02 110 792575 8564 109788050
Infusion site reaction 14.91 10.02 193 792492 17489 109779125
Genital haemorrhage 14.89 10.02 18 792667 7234 109789380
Spinal osteoarthritis 14.85 10.02 215 792470 19968 109776646
Bone density increased 14.76 10.02 26 792659 969 109795645
Head injury 14.76 10.02 218 792467 42799 109753815
Epstein-Barr virus associated lymphoproliferative disorder 14.75 10.02 8 792677 4794 109791820
Breast cancer stage II 14.73 10.02 277 792408 27098 109769516
Insurance issue 14.69 10.02 34 792651 10578 109786036
Extravascular haemolysis 14.61 10.02 17 792668 429 109796185
Autonomic nervous system imbalance 14.56 10.02 12 792673 5768 109790846
Hypoglycaemic coma 14.55 10.02 11 792674 5522 109791092
Haemorrhage in pregnancy 14.55 10.02 35 792650 1633 109794981
Bronchial secretion retention 14.53 10.02 9 792676 5015 109791599
Sickle cell anaemia 14.53 10.02 23 792662 784 109795830
Bone density abnormal 14.53 10.02 61 792624 3842 109792772
Placental insufficiency 14.49 10.02 30 792655 1264 109795350
Enterococcal infection 14.48 10.02 86 792599 20280 109776334
Accidental overdose 14.41 10.02 273 792412 51561 109745053
Nail injury 14.41 10.02 23 792662 790 109795824
Hepatic necrosis 14.38 10.02 31 792654 9891 109786723
Staphylococcal bacteraemia 14.37 10.02 66 792619 16622 109779992
Impaired gastric emptying 14.31 10.02 48 792637 13227 109783387
Neoplasm recurrence 14.28 10.02 10 792675 5222 109791392
Epstein-Barr viraemia 14.22 10.02 4 792681 3575 109793039
Clostridium test positive 14.21 10.02 36 792649 10857 109785757
Bone marrow failure 14.20 10.02 311 792374 57537 109739077
Ligament rupture 14.20 10.02 62 792623 3973 109792641
Multiple allergies 14.16 10.02 43 792642 12220 109784394
Intraocular pressure increased 14.14 10.02 36 792649 10840 109785774
Hypovolaemia 14.13 10.02 94 792591 21580 109775034
Mitochondrial toxicity 14.12 10.02 3 792682 3242 109793372
Anal fissure 14.10 10.02 120 792565 9761 109786853
Behaviour disorder 14.10 10.02 30 792655 9617 109786997
Bradyarrhythmia 14.05 10.02 9 792676 4925 109791689
Cushingoid 14.05 10.02 137 792548 11575 109785039
Pharyngeal swelling 14.03 10.02 42 792643 11990 109784624
Cytomegalovirus colitis 14.00 10.02 18 792667 7043 109789571
Nervousness 13.99 10.02 183 792502 36668 109759946
Progressive multifocal leukoencephalopathy 13.98 10.02 113 792572 24843 109771771
Central nervous system mass 13.97 10.02 23 792662 811 109795803
Heart rate irregular 13.96 10.02 333 792352 33941 109762673
Immune thrombocytopenia 13.95 10.02 99 792586 22395 109774219
Gastric cancer 13.88 10.02 37 792648 10971 109785643
Mental impairment 13.86 10.02 100 792585 22539 109774075
Wall motion score index abnormal 13.83 10.02 23 792662 818 109795796
Accidental exposure to product by child 13.82 10.02 3 792682 3195 109793419
Injection site swelling 13.82 10.02 558 792127 61232 109735382
Obsessive-compulsive disorder 13.81 10.02 19 792666 7222 109789392
Hyperventilation 13.77 10.02 27 792658 8920 109787694
Lower gastrointestinal haemorrhage 13.71 10.02 77 792608 18409 109778205
Wrong product administered 13.70 10.02 37 792648 10923 109785691
Hepatic cancer 13.69 10.02 38 792647 11118 109785496
Hypoventilation 13.68 10.02 23 792662 8058 109788556
Nightmare 13.67 10.02 196 792489 38667 109757947
Corneal oedema 13.67 10.02 3 792682 3170 109793444
Lacrimal disorder 13.64 10.02 18 792667 518 109796096
Lymph gland infection 13.63 10.02 20 792665 637 109795977
Haematocrit decreased 13.63 10.02 592 792093 65525 109731089
Plasma cell myeloma 13.60 10.02 345 792340 62591 109734023
Hallucinations, mixed 13.59 10.02 26 792659 8667 109787947
Blood folate increased 13.58 10.02 19 792666 579 109796035
Gait disturbance 13.58 10.02 2231 790454 275977 109520637
Pancreatic steatosis 13.56 10.02 36 792649 1786 109794828
Swollen tongue 13.56 10.02 329 792356 60033 109736581
Acute lung injury 13.53 10.02 3 792682 3148 109793466
Pneumonia fungal 13.53 10.02 57 792628 14697 109781917
Pain of skin 13.50 10.02 86 792599 19943 109776671
Troponin T increased 13.48 10.02 7 792678 4299 109792315
Cerebral toxoplasmosis 13.47 10.02 3 792682 3139 109793475
Induced labour 13.47 10.02 24 792661 903 109795711
Renal cancer 13.46 10.02 48 792637 12986 109783628
Lip oedema 13.46 10.02 21 792664 7579 109789035
Hand fracture 13.42 10.02 102 792583 8020 109788594
Coeliac disease 13.40 10.02 405 792280 42782 109753832
Taste disorder 13.38 10.02 585 792100 64802 109731812
Procedural pain 13.36 10.02 177 792508 35388 109761226
Cervical incompetence 13.35 10.02 18 792667 529 109796085
Drooling 13.35 10.02 19 792666 7120 109789494
Injection site rash 13.31 10.02 239 792446 23180 109773434
Upper gastrointestinal haemorrhage 13.27 10.02 266 792419 49830 109746784
Cardiac dysfunction 13.26 10.02 15 792670 6208 109790406
Spinal cord compression 13.25 10.02 21 792664 7531 109789083
Delayed graft function 13.21 10.02 7 792678 4250 109792364
Sneezing 13.20 10.02 156 792529 31828 109764786
Cyst rupture 13.16 10.02 23 792662 852 109795762
Granulocyte count decreased 13.14 10.02 6 792679 3968 109792646
Reversible cerebral vasoconstriction syndrome 13.13 10.02 9 792676 4752 109791862
Anger 13.12 10.02 81 792604 18926 109777688
Steroid diabetes 13.12 10.02 11 792674 5243 109791371
Iritis 13.10 10.02 67 792618 4585 109792029
Tumour haemorrhage 13.08 10.02 11 792674 5234 109791380
Nystagmus 13.08 10.02 41 792644 11536 109785078
Abortion incomplete 13.04 10.02 3 792682 3069 109793545
Pseudomembranous colitis 12.98 10.02 16 792669 6375 109790239
Extradural haematoma 12.96 10.02 4 792681 3365 109793249
Kounis syndrome 12.93 10.02 14 792671 5911 109790703
Back pain 12.91 10.02 2402 790283 368594 109428020
Lymphoedema 12.88 10.02 59 792626 14870 109781744
Blood loss anaemia 12.87 10.02 76 792609 17949 109778665
Vein disorder 12.86 10.02 83 792602 6187 109790427
Ataxia 12.76 10.02 146 792539 29962 109766652
Secondary adrenocortical insufficiency 12.75 10.02 8 792677 4426 109792188
Hyperthermia malignant 12.72 10.02 6 792679 3894 109792720
Renal tubular disorder 12.71 10.02 21 792664 7408 109789206
Retinal haemorrhage 12.71 10.02 31 792654 9470 109787144
Areflexia 12.67 10.02 18 792667 6751 109789863
Fungaemia 12.61 10.02 15 792670 6071 109790543
Crying 12.60 10.02 120 792565 25508 109771106
Urinary incontinence 12.57 10.02 259 792426 48328 109748286
Dysuria 12.53 10.02 332 792353 59899 109736715
Joint lock 12.53 10.02 55 792630 3533 109793081
Hypopituitarism 12.51 10.02 8 792677 4382 109792232
Complication of device insertion 12.49 10.02 28 792657 8810 109787804
Transient aphasia 12.48 10.02 20 792665 689 109795925
Bronchopulmonary aspergillosis allergic 12.48 10.02 26 792659 8400 109788214
Dermatitis bullous 12.47 10.02 74 792611 17455 109779159
Mitral valve incompetence 12.47 10.02 166 792519 33163 109763451
Defaecation disorder 12.43 10.02 22 792663 823 109795791
Hypertension 12.43 10.02 3961 788724 506123 109290491
Hypertonia 12.40 10.02 26 792659 8380 109788234
Post procedural haemorrhage 12.40 10.02 63 792622 15449 109781165
Oligoarthritis 12.36 10.02 21 792664 760 109795854
Human anti-human antibody test 12.36 10.02 15 792670 396 109796218
Viraemia 12.36 10.02 7 792678 4095 109792519
Blood potassium increased 12.29 10.02 166 792519 33083 109763531
Epstein-Barr virus infection reactivation 12.26 10.02 7 792678 4077 109792537
Dermatitis exfoliative 12.25 10.02 41 792644 11306 109785308
Wrong patient received product 12.25 10.02 18 792667 6656 109789958
Liver abscess 12.22 10.02 23 792662 7716 109788898
Injection site extravasation 12.22 10.02 119 792566 10050 109786564
Burns second degree 12.16 10.02 96 792589 7637 109788977
Tender joint count increased 12.16 10.02 15 792670 403 109796211
Infusion site pain 12.15 10.02 74 792611 17345 109779269
Blood glucose decreased 12.10 10.02 144 792541 29344 109767270
Spinal disorder 12.08 10.02 133 792552 11595 109785019
C-reactive protein decreased 12.05 10.02 47 792638 2862 109793752
Product monitoring error 12.04 10.02 29 792656 8898 109787716
Product dose omission in error 12.03 10.02 109 792576 23403 109773211
Pneumomediastinum 12.03 10.02 11 792674 5025 109791589
Clonus 12.00 10.02 28 792657 8688 109787926
Vascular purpura 12.00 10.02 6 792679 3765 109792849
Paronychia 11.99 10.02 40 792645 11041 109785573
Threatened labour 11.98 10.02 19 792666 649 109795965
Respiratory tract infection 11.96 10.02 628 792057 70989 109725625
Airway remodelling 11.94 10.02 23 792662 919 109795695
Arteriospasm coronary 11.93 10.02 30 792655 9070 109787544
Pupillary reflex impaired 11.88 10.02 7 792678 4008 109792606
Medication error 11.87 10.02 893 791792 104473 109692141
Parvovirus B19 infection 11.86 10.02 3 792682 2878 109793736
Immunisation 11.85 10.02 4 792681 3179 109793435
Feeding disorder 11.84 10.02 97 792588 21265 109775349
Skin weeping 11.80 10.02 6 792679 3729 109792885
Cold sweat 11.78 10.02 101 792584 21930 109774684
Bone fissure 11.76 10.02 18 792667 596 109796018
Musculoskeletal disorder 11.74 10.02 228 792457 22436 109774178
Nephrotic syndrome 11.73 10.02 55 792630 13776 109782838
Oxygen saturation decreased 11.67 10.02 1291 791394 155691 109640923
Hypothalamo-pituitary disorder 11.65 10.02 3 792682 2843 109793771
Tension headache 11.63 10.02 33 792652 9585 109787029
Cogwheel rigidity 11.59 10.02 6 792679 3692 109792922
Quadriparesis 11.58 10.02 10 792675 4697 109791917
Schizoaffective disorder 11.57 10.02 4 792681 3132 109793482
Drug abuser 11.57 10.02 13 792672 5396 109791218
Prerenal failure 11.56 10.02 9 792676 4450 109792164
Carcinoid tumour of the small bowel 11.55 10.02 15 792670 425 109796189
Pancreatitis 11.54 10.02 550 792135 92983 109703631
Pneumonitis 11.54 10.02 440 792245 76091 109720523
Device breakage 11.54 10.02 55 792630 13714 109782900
Breast cancer female 11.53 10.02 48 792637 12420 109784194
Leukoencephalopathy 11.53 10.02 31 792654 9164 109787450
Joint warmth 11.52 10.02 37 792648 2045 109794569
Labyrinthitis 11.51 10.02 48 792637 3014 109793600
Alcohol abuse 11.50 10.02 11 792674 4918 109791696
Oesophageal fibrosis 11.48 10.02 10 792675 176 109796438
Embolism 11.47 10.02 69 792616 16220 109780394
Cardiac tamponade 11.44 10.02 42 792643 11265 109785349
Aphthous ulcer 11.42 10.02 214 792471 20922 109775692
Rash morbilliform 11.39 10.02 25 792660 7926 109788688
Full blood count abnormal 11.39 10.02 310 792375 55742 109740872
Thirst 11.39 10.02 100 792585 21607 109775007
Cystoid macular oedema 11.37 10.02 3 792682 2797 109793817
Liver transplant rejection 11.36 10.02 7 792678 3911 109792703
Erythema of eyelid 11.34 10.02 7 792678 3908 109792706
Autoimmune hepatitis 11.34 10.02 61 792624 14743 109781871
Increased appetite 11.32 10.02 62 792623 14915 109781699
Eye movement disorder 11.31 10.02 34 792651 9694 109786920
Cardiopulmonary failure 11.20 10.02 25 792660 7878 109788736
Subileus 11.20 10.02 18 792667 6419 109790195
Device issue 11.17 10.02 177 792508 34358 109762256
Choking 11.17 10.02 63 792622 15047 109781567
Osteoporotic fracture 11.16 10.02 71 792614 5266 109791348
Hypochloraemia 11.15 10.02 6 792679 3612 109793002
Rhinovirus infection 11.15 10.02 45 792640 11744 109784870
Mycobacterium chelonae infection 11.13 10.02 4 792681 3056 109793558
Haemorrhage subcutaneous 11.11 10.02 14 792671 5525 109791089
Uveitis 11.11 10.02 218 792467 21492 109775122
Dizziness 11.10 10.02 4676 788009 693517 109103097
Anaesthetic complication 11.09 10.02 6 792679 3600 109793014
Inadequate analgesia 11.08 10.02 12 792673 5065 109791549
Blood phosphorus decreased 11.07 10.02 24 792661 7641 109788973
Brain herniation 11.02 10.02 30 792655 8833 109787781
Myofascial pain syndrome 11.01 10.02 42 792643 2531 109794083
Pancreatic carcinoma 11 10.02 62 792623 14810 109781804
Tumour marker increased 11.00 10.02 12 792673 5048 109791566
Haemorrhagic transformation stroke 10.99 10.02 4 792681 3033 109793581
Clear cell renal cell carcinoma 10.99 10.02 44 792641 2712 109793902
Middle insomnia 10.96 10.02 94 792591 20408 109776206
Fibroadenoma of breast 10.94 10.02 19 792666 700 109795914
Hypoproteinaemia 10.94 10.02 16 792669 5929 109790685
Tooth disorder 10.91 10.02 283 792402 29226 109767388
Disorganised speech 10.90 10.02 5 792680 3298 109793316
Oculogyric crisis 10.90 10.02 7 792678 3825 109792789
Abortion threatened 10.85 10.02 15 792670 452 109796162
Angina unstable 10.85 10.02 71 792614 16361 109780253
Brain abscess 10.82 10.02 20 792665 6754 109789860
Pharyngitis streptococcal 10.81 10.02 144 792541 13133 109783481
Cancer pain 10.81 10.02 20 792665 6752 109789862
Catatonia 10.77 10.02 43 792642 11257 109785357
Skin graft failure 10.75 10.02 11 792674 239 109796375
Staphylococcal sepsis 10.74 10.02 77 792608 17377 109779237
Apraxia 10.72 10.02 6 792679 3534 109793080
Terminal state 10.68 10.02 15 792670 5652 109790962
Hypovolaemic shock 10.68 10.02 61 792624 14522 109782092
Skin necrosis 10.67 10.02 215 792470 21297 109775317
CD4 lymphocytes decreased 10.62 10.02 4 792681 2970 109793644
Breast abscess 10.61 10.02 32 792653 1709 109794905
Fanconi syndrome 10.61 10.02 6 792679 3513 109793101
Tubulointerstitial nephritis 10.58 10.02 302 792383 53982 109742632
Apnoea 10.56 10.02 56 792629 13583 109783031
Candida sepsis 10.55 10.02 4 792681 2957 109793657
Pallor 10.54 10.02 316 792369 56151 109740463
Hereditary angioedema 10.50 10.02 22 792663 7092 109789522
Tonic clonic movements 10.50 10.02 4 792681 2948 109793666
Immune-mediated myocarditis 10.49 10.02 6 792679 3492 109793122
Twin pregnancy 10.48 10.02 22 792663 936 109795678
Cough 10.45 10.02 3050 789635 458591 109338023
Tuberculin test positive 10.45 10.02 53 792632 3615 109792999
Peritoneal dialysis complication 10.44 10.02 41 792644 2505 109794109
Unevaluable event 10.43 10.02 334 792351 58893 109737721
Facial paralysis 10.42 10.02 117 792568 24097 109772517
Lip and/or oral cavity cancer 10.41 10.02 25 792660 1165 109795449
Knee operation 10.40 10.02 86 792599 6936 109789678
Hypokinesia 10.40 10.02 103 792582 21723 109774891
Resuscitation 10.39 10.02 4 792681 2929 109793685
Drug specific antibody 10.37 10.02 44 792641 2784 109793830
Swollen joint count decreased 10.23 10.02 13 792672 360 109796254
Exercise tolerance decreased 10.23 10.02 48 792637 12019 109784595
Renal disorder 10.22 10.02 273 792412 49206 109747408
Mesothelioma 10.21 10.02 13 792672 361 109796253
Vertebral osteophyte 10.20 10.02 16 792669 541 109796073
Inflammatory marker increased 10.20 10.02 153 792532 14316 109782298
Vacuum extractor delivery 10.19 10.02 8 792677 121 109796493
Therapeutic product effect incomplete 10.17 10.02 1788 790897 222017 109574597
Alcohol interaction 10.17 10.02 7 792678 3687 109792927
Eyelid ptosis 10.16 10.02 55 792630 13272 109783342
Lip blister 10.15 10.02 49 792636 3276 109793338
Hospitalisation 10.13 10.02 881 791804 141612 109655002
Abortion missed 10.09 10.02 29 792656 1508 109795106
Hepatitis E antibody positive 10.08 10.02 11 792674 258 109796356
Trismus 10.07 10.02 20 792665 6576 109790038
Joint ankylosis 10.07 10.02 40 792645 2457 109794157
Throat tightness 10.06 10.02 174 792511 33315 109763299
Ischaemic cardiomyopathy 10.05 10.02 27 792658 7984 109788630

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000975 Antioxidants
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:38068 antimalarial

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

None

External reference:

IDSource
4017691 VUID
N0000179281 NUI
D01735 KEGG_DRUG
52225-20-4 SECONDARY_CAS_RN
7695-91-2 SECONDARY_CAS_RN
4017635 VANDF
4017691 VANDF
4017773 VANDF
4020803 VANDF
C1999896 UMLSCUI
CHEBI:32321 CHEBI
CHEMBL3989859 ChEMBL_ID
CHEMBL3989727 ChEMBL_ID
D024502 MESH_DESCRIPTOR_UI
DB14003 DRUGBANK_ID
86472 PUBCHEM_CID
DB14002 DRUGBANK_ID
1046243 RXNORM
7433 MMSL
001021 NDDF
007607 NDDF
009945 NDDF
16132211000001106 SNOMEDCT_US
31075011000036101 SNOMEDCT_US
395830006 SNOMEDCT_US
812391000168102 SNOMEDCT_US
C0606070 UMLSCUI
DB11635 DRUGBANK_ID
WR1WPI7EW8 UNII
CHEBI:753119 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 11 [iU] ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 30 [iU] ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 30 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 30 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 30 [iU] ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 30 [iU] ORAL Unapproved drug other 11 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 30 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 9 mg ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 30 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 9 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 30 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 30 [iU] ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 30 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 22 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 22 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 30 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 30 [iU] ORAL unapproved drug other 16 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 5 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 12 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 5 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
TriStart DHA HUMAN PRESCRIPTION DRUG LABEL 15 15370-250 CAPSULE, LIQUID FILLED 15 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 22 mg ORAL UNAPPROVED DRUG OTHER 6 sections
SimmyungSaengMoSuHair tonic HUMAN OTC DRUG LABEL 3 32819-1001 LIQUID 3 mL TOPICAL unapproved drug other 8 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 10 mg ORAL UNAPPROVED DRUG OTHER 7 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 10 [iU] ORAL unapproved drug other 10 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 10 42192-321 CAPSULE, GELATIN COATED 10 [iU] ORAL unapproved drug other 11 sections
PNV-DHA HUMAN PRESCRIPTION DRUG LABEL 8 42192-323 CAPSULE, GELATIN COATED 30 [iU] ORAL unapproved drug other 11 sections
PNV Prenatal VitaminPlus Vitamin A HUMAN PRESCRIPTION DRUG LABEL 12 44946-1046 TABLET 15 [iU] ORAL UNAPPROVED DRUG OTHER 9 sections
WHITE HAND SANITIZER HUMAN OTC DRUG LABEL 3 47993-207 LIQUID 0.60 g TOPICAL OTC monograph not final 8 sections
HAND SANITIZER WITH VE HUMAN OTC DRUG LABEL 2 47993-301 LIQUID 1.50 g TOPICAL OTC monograph not final 8 sections