brotizolam indications/contra

Stem definitionDrug idCAS RN
diazepam derivatives 409 57801-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • brotizolam
  • mederantil
  • lendorm
  • Molecular weight: 393.69
  • Formula: C15H10BrClN4S
  • CLOGP: 2.71
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 43.07
  • ALOGS: -3.83
  • ROTB: 1

Drug dosage:

DoseUnitRoute
0.25 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1983 YEAR INTRODUCED

FDA Adverse Event Reporting System

scroll-->
MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Suicide attempt 147.87 53.90 32 151 15815 3369861
Overdose 99.31 53.90 27 156 33951 3351725
Drug abuse 64.64 53.90 17 166 18313 3367363
Intentional overdose 62.78 53.90 16 167 15209 3370467

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC N05CD09 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Benzodiazepine derivatives
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D006993 Hypnotics and Sedatives

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.34 Basic
pKa2 4.87 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Platelet-activating factor receptor GPCR IC50 6.52 CHEMBL

External reference:

scroll-->
IDSource
C0054151 UMLSCUI
D01744 KEGG_DRUG
5XZM1R3DKF UNII
4549 INN_ID
CHEMBL32479 ChEMBL_ID
19790 RXNORM
698050003 SNOMEDCT_US
004151 NDDF
2451 PUBCHEM_CID
C020960 MESH_SUPPLEMENTAL_RECORD_UI
DB09017 DRUGBANK_ID
CHEBI:31308 CHEBI

Pharmaceutical products:

None