loprazolam indications/contra

Stem definitionDrug idCAS RN
diazepam derivatives 1602 61197-73-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • loprazolam mesylate
  • loprazolam
  • loprazolam mesilate
  • Molecular weight: 464.91
  • Formula: C23H21ClN6O3
  • CLOGP: 0.43
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 0
  • TPSA: 97.33
  • ALOGS: -3.71
  • ROTB: 3

Drug dosage:

DoseUnitRoute
1 mg O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1983 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

scroll-->
SourceCodeDescription
ATC N05CD11 NERVOUS SYSTEM
PSYCHOLEPTICS
HYPNOTICS AND SEDATIVES
Benzodiazepine derivatives

Drug Use (View source of the data)

scroll-->
DiseaseRelationSNOMED_IDDOID
Insomnia indication 193462001

Acid dissociation constants calculated using MoKa v3.0.0

scroll-->
Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 Basic
pKa2 4.28 Basic
pKa3 2.6 Basic
pKa4 1.98 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

scroll-->
TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel WOMBAT-PK
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel WOMBAT-PK
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel WOMBAT-PK
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel WOMBAT-PK

External reference:

scroll-->
IDSource
C0771040 UMLSCUI
D07326 KEGG_DRUG
759N8462G8 UNII
4884 INN_ID
38555 RXNORM
321119005 SNOMEDCT_US
395774003 SNOMEDCT_US
004097 NDDF
3033860 PUBCHEM_CID
CHEMBL2107448 ChEMBL_ID
70111-54-5 SECONDARY_CAS_RN
DB13643 DRUGBANK_ID
CHEBI:135754 CHEBI

Pharmaceutical products:

None