ascorbic acid indications/contra

Stem definitionDrug idCAS RN
4072 50-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vitamin c
  • L-Ascorbic acid
  • ascorbic acid
  • ascorbic acid (vit C)
  • sodium ascorbate
  • calcium ascorbate
  • ascorbic acid, monosodium salt
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
  • Molecular weight: 176.12
  • Formula: C6H8O6
  • CLOGP: -1.76
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 4
  • TPSA: 107.22
  • ALOGS: 0.14
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.20 g O
0.20 g P
0.25 g V

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia aspiration 91.14 31.54 23 508 7065 3378263
Exposure during pregnancy 90.62 31.54 31 500 27532 3357796
Somnolence 85.90 31.54 31 500 32173 3353155
Coma 78.11 31.54 23 508 12529 3372799
Acute kidney injury 76.21 31.54 32 499 49651 3335677
Gastrooesophageal reflux disease 70.87 31.54 21 510 11670 3373658
Chills 69.26 31.54 24 507 21998 3363330
Product compounding quality issue 61.67 31.54 8 523 49 3385279
Fatigue 58.13 31.54 34 497 107206 3278122
Muscle spasticity 56.32 31.54 13 518 2723 3382605
Nephropathy 52.91 31.54 11 520 1419 3383909
Pyrexia 52.71 31.54 29 502 81086 3304242
Vomiting 50.04 31.54 29 502 89502 3295826
Nausea 49.71 31.54 33 498 129612 3255716
Stillbirth 46.18 31.54 10 521 1565 3383763
Drug hypersensitivity 44.74 31.54 20 511 35660 3349668
Completed suicide 44.05 31.54 19 512 31095 3354233
Abortion 41.13 31.54 8 523 736 3384592
Intentional overdose 37.95 31.54 14 517 15211 3370117
Foetal exposure during pregnancy 34.02 31.54 13 518 15538 3369790
Muscular weakness 34.01 31.54 14 517 20327 3365001
Dyspnoea 31.74 31.54 23 508 102911 3282417
Lethargy 31.67 31.54 12 519 14003 3371325

Pharmacologic Action:

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SourceCodeDescription
ATC A11GA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), plain
ATC A11GB01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
ASCORBIC ACID (VITAMIN C), INCL. COMBINATIONS
Ascorbic acid (vitamin C), combinations
ATC G01AD03 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Organic acids
ATC S01XA15 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
CHEBI has role CHEBI:21241 vitamin C
CHEBI has role CHEBI:64577 flour treatment agent
CHEBI has role CHEBI:77962 food antioxidant
FDA Chemical/Ingredient N0000006439 Ascorbic Acid
MeSH PA D000975 Antioxidants
MeSH PA D006133 Growth Substances
MeSH PA D018977 Micronutrients
MeSH PA D020011 Protective Agents
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Ascorbic acid deficiency indication 76169001 DOID:13724
Breastfeeding (mother) indication 413712001
Anuria contraindication 2472002 DOID:2983
Hypocalcemia contraindication 5291005
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Operation on stomach contraindication 16453004
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hypocupremia contraindication 19577007
Hyperphosphatemia contraindication 20165001 DOID:0050459
Sunburn contraindication 23346002
Acute vomiting contraindication 23971007
Multiple sclerosis contraindication 24700007 DOID:2377
Gastroenteritis contraindication 25374005 DOID:2326
Acute tuberculosis contraindication 25629007
Hypervitaminosis D contraindication 27712000 DOID:9971
Complete atrioventricular block contraindication 27885002
Toxic megacolon contraindication 28536002 DOID:1770
Dental fluorosis contraindication 30265004 DOID:13711
Sarcoidosis contraindication 31541009 DOID:13404
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Hemosiderosis contraindication 39011001 DOID:12119
Gastrointestinal ulcer contraindication 40845000
Toxic colitis contraindication 42359007
Hypokalemia contraindication 43339004
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Hyperlipidemia contraindication 55822004 DOID:1168
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hemolytic anemia contraindication 61261009 DOID:583
Allergic rhinitis contraindication 61582004
Hypervitaminosis A contraindication 64559002 DOID:9972
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Rheumatoid arthritis contraindication 69896004 DOID:7148
Diabetes mellitus contraindication 73211009 DOID:9351
Hyperchloremia contraindication 74450001
Third degree burn injury contraindication 80247002
Intestinal obstruction contraindication 81060008 DOID:8437
Atrophic gastritis contraindication 84568007 DOID:8929
Human immunodeficiency virus infection contraindication 86406008 DOID:526
Wilson's disease contraindication 88518009 DOID:893
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:2527
Leukemia, disease contraindication 93143009 DOID:1240
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Hb SS disease contraindication 127040003 DOID:10923
Seizure disorder contraindication 128613002 DOID:1826
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Hyporeninemic hypoaldosteronism contraindication 236464008
Esophageal dysmotility contraindication 266434009 DOID:9192
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Gastric retention contraindication 307227006
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
At risk for aspiration contraindication 371736008
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Denuded skin contraindication 418242004
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
Repeated Blood Transfusions contraindication

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.02 acidic
pKa2 9.62 acidic
pKa3 11.85 acidic
pKa4 12.53 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

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Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
25,000MG/50ML (500MG/ML) ASCOR MCGUFF N209112 Oct. 2, 2017 RX SOLUTION IV (INFUSION) Oct. 2, 2024 FOR TREATMENT OF SCURVY IN ADULT AND PEDIATRIC PATIENTS AGE 5 MONTHS AND OLDER FOR WHOM ORAL ADMINISTRATION IS NOT POSSIBLE, INSUFFICIENT OR CONTRAINDICATED

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Solute carrier family 23 member 1 Unclassified WOMBAT-PK
Solute carrier family 23 member 2 Transporter WOMBAT-PK
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 Enzyme WOMBAT-PK
Prolyl 4-hydroxylase subunit alpha-1 Enzyme WOMBAT-PK
Tyrosinase Enzyme IC50 4.49 CHEMBL
Pancreatic alpha-amylase Unclassified IC50 4.58 CHEMBL

External reference:

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IDSource
CHEBI:29073 CHEBI
DB00126 DRUGBANK_ID
4017646 VUID
N0000146025 NUI
C0003968 UMLSCUI
4781 IUPHAR_LIGAND_ID
D00018 KEGG_DRUG
183E4W213W UNII
5743-28-2 SECONDARY_CAS_RN
4017471 VANDF
4017646 VANDF
N0000145859 NDFRT
N0000006439 NDFRT
N0000146025 NDFRT
001010 NDDF
6032 MMSL
1151 RXNORM
43706004 SNOMEDCT_US
4221 MMSL
d00426 MMSL
1132 MMSL
5687 MMSL
46123006 SNOMEDCT_US
CHEMBL196 ChEMBL_ID
CHEMBL591665 ChEMBL_ID
C069207 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2146095 ChEMBL_ID
372 INN_ID
D001205 MESH_DESCRIPTOR_UI
54670067 PUBCHEM_CID
ASC PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
PreferaOB ONE HUMAN PRESCRIPTION DRUG LABEL 11 0037-0086 CAPSULE, LIQUID FILLED 25 mg ORAL Unapproved drug other 13 sections
Natelle One HUMAN PRESCRIPTION DRUG LABEL 7 0037-6072 CAPSULE, GELATIN COATED 30 mg ORAL Unapproved drug other 11 sections
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 120 mg ORAL unapproved drug other 14 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 120 mg ORAL Unapproved drug other 12 sections
CitraNatal Bloom HUMAN PRESCRIPTION DRUG LABEL 6 0178-0813 TABLET, FILM COATED 138 mg ORAL unapproved drug other 13 sections
CitraNatal Bloom DHA HUMAN PRESCRIPTION DRUG LABEL 6 0178-0816 KIT 120 mg ORAL unapproved drug other 10 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 13 0178-0821 TABLET 120 mg ORAL Unapproved drug other 10 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 10 0178-0829 TABLET 120 mg ORAL Unapproved drug other 10 sections
CITRANATAL B-CALM HUMAN PRESCRIPTION DRUG LABEL 6 0178-0832 KIT 120 mg None unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 11 0178-0858 TABLET 120 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 12 0178-0859 TABLET 120 mg ORAL Unapproved drug other 8 sections
CitraNatal HUMAN PRESCRIPTION DRUG LABEL 7 0178-0866 KIT 120 mg None Unapproved drug other 11 sections
CitraNatal Assure HUMAN PRESCRIPTION DRUG LABEL 13 0178-0891 KIT 120 mg None unapproved drug other 12 sections
CitraNatal Assure HUMAN PRESCRIPTION DRUG LABEL 14 0178-0893 KIT 120 mg None Unapproved drug other 12 sections
CitraNatal DHA HUMAN PRESCRIPTION DRUG LABEL 14 0178-0894 KIT 120 mg None unapproved drug other 11 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 12 0178-0898 TABLET 120 mg ORAL Unapproved drug other 10 sections
Antiflu Kids HUMAN OTC DRUG LABEL 3 0280-0046 POWDER, FOR SOLUTION 50 mg ORAL Export only 1 sections
Ascorbic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0389-0486 INJECTION, SOLUTION 500 mg INTRAVENOUS unapproved drug other 10 sections
Multi-Vit with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 0603-1449 SOLUTION 35 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Multi-Vit with Fluoride HUMAN PRESCRIPTION DRUG LABEL 10 0603-1450 SOLUTION 35 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Multi-Vit with Fluoride and Iron HUMAN PRESCRIPTION DRUG LABEL 10 0603-1452 SOLUTION 35 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Tri-Vit with Fluoride Drops HUMAN PRESCRIPTION DRUG LABEL 4 0603-1785 SOLUTION 35 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Tri-Vit with Fluoride Drops HUMAN PRESCRIPTION DRUG LABEL 4 0603-1786 SOLUTION 35 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Tri-Vit With Fluoride And Iron Drops HUMAN PRESCRIPTION DRUG LABEL 5 0603-1787 SOLUTION 35 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 11 0642-0070 CAPSULE, GELATIN COATED 30 mg ORAL unapproved drug other 6 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 9 0642-0072 CAPSULE 60 mg ORAL UNAPPROVED DRUG OTHER 9 sections
Select-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 14 0642-0075 KIT 60 mg None Unapproved drug other 7 sections
Vitafol-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 10 0642-0076 KIT 70 mg None Unapproved drug other 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 11 0642-0077 TABLET, CHEWABLE 60 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Vitafol OB HUMAN PRESCRIPTION DRUG LABEL 9 0642-0079 TABLET 70 mg ORAL Unapproved drug other 11 sections