piritramide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3478 302-41-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • piritramide
  • dipidolor
  • dipiritramide
  • pirdolan
  • piridolan
  • pirinitramide
A diphenylpropylamine with intense narcotic analgesic activity of long duration. It is a derivative of MEPERIDINE with similar activity and usage.
  • Molecular weight: 430.60
  • Formula: C27H34N4O
  • CLOGP: 3.19
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 73.36
  • ALOGS: -4.63
  • ROTB: 7

Drug dosage:

DoseUnitRoute
45 mg P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 4.70 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.06 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic epidermal necrolysis 83.40 35.14 31 1974 25303 63461714
Basal ganglion degeneration 68.97 35.14 12 1993 436 63486581
Patent ductus arteriosus 65.51 35.14 17 1988 4233 63482784
Tissue infiltration 64.90 35.14 12 1993 617 63486400
Anaesthesia 62.59 35.14 11 1994 424 63486593
Uterine enlargement 56.51 35.14 12 1993 1256 63485761
Stevens-Johnson syndrome 55.51 35.14 23 1982 24927 63462090
Congenital central hypoventilation syndrome 54.09 35.14 7 1998 29 63486988
Psychogenic seizure 53.06 35.14 12 1993 1680 63485337
Inguinal hernia 51.02 35.14 12 1993 1995 63485022
Renal cyst 50.65 35.14 17 1988 10285 63476732
Neurological decompensation 47.76 35.14 12 1993 2626 63484391
Monoplegia 45.46 35.14 12 1993 3189 63483828
Dysaesthesia 41.47 35.14 12 1993 4466 63482551
Hypochromic anaemia 41.03 35.14 10 1995 1932 63485085
Abdominal tenderness 38.26 35.14 13 1992 8153 63478864
Intervertebral disc disorder 36.21 35.14 11 1994 4832 63482185

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood pressure measurement 91.90 45.62 13 784 167 34955967
Weight bearing difficulty 68.45 45.62 13 784 1082 34955052
Hyperventilation 56.17 45.62 13 784 2811 34953323
Oropharyngeal discomfort 54.57 45.62 13 784 3183 34952951

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hyperventilation 79.03 35.35 22 2262 7877 79734227
Blood pressure measurement 76.88 35.35 13 2271 440 79741664
Basal ganglion degeneration 63.33 35.35 11 2273 437 79741667
Toxic epidermal necrolysis 59.89 35.35 28 2256 44553 79697551
Tissue infiltration 58.57 35.35 11 2273 680 79741424
Uterine enlargement 55.57 35.35 11 2273 897 79741207
Anaesthesia 55.00 35.35 10 2274 517 79741587
Congenital central hypoventilation syndrome 54.77 35.35 7 2277 29 79742075
Stevens-Johnson syndrome 53.85 35.35 25 2259 39141 79702963
Weight bearing difficulty 51.46 35.35 13 2271 3208 79738896
Psychogenic seizure 47.30 35.35 11 2273 1920 79740184
Speech disorder 43.28 35.35 24 2260 54421 79687683
Inguinal hernia 42.44 35.35 13 2271 6475 79735629
Oropharyngeal discomfort 41.17 35.35 13 2271 7153 79734951
Cardiovascular disorder 39.51 35.35 16 2268 18009 79724095
Monoplegia 39.43 35.35 11 2273 3960 79738144
Hypochromic anaemia 38.54 35.35 10 2274 2741 79739363
Neurological decompensation 36.39 35.35 11 2273 5242 79736862

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02AC03 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Diphenylpropylamine derivatives
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.07 Basic
pKa2 6.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167338 NUI
D07288 KEGG_DRUG
C0031982 UMLSCUI
CHEBI:135699 CHEBI
CHEMBL559288 ChEMBL_ID
DB12492 DRUGBANK_ID
9331 PUBCHEM_CID
1343 INN_ID
4RP92LYZ2F UNII
8354 RXNORM
006892 NDDF
707837002 SNOMEDCT_US
D010892 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None