dimercaprol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3150 59-52-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dimercaprol
  • dithioglycerine
  • dicaptol
An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
  • Molecular weight: 124.22
  • Formula: C3H8OS2
  • CLOGP: 0.18
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -1.65
  • ROTB: 2

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
May 6, 1946 FDA AKORN

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC V03AB09 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
FDA MoA N0000175472 Metal Chelating Activity
FDA EPC N0000175473 Metal Chelator
MeSH PA D002614 Chelating Agents
MeSH PA D064449 Sequestering Agents
CHEBI has role CHEBI:38161 Chelating agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Toxic effect of arsenic AND/OR its compounds indication 81844008
Accidental poisoning by lead and its compounds and fumes indication 216777009
Gold Toxicity indication
Mercury Toxicity indication
Hypertensive disorder contraindication 38341003 DOID:10763
Poisoning by iron AND/OR its compounds contraindication 55381001
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Disease of liver contraindication 235856003 DOID:409
Cadmium Toxicity contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.91 acidic
pKa2 11.55 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018102 VUID
N0000146440 NUI
D00167 KEGG_DRUG
4018102 VANDF
C0012383 UMLSCUI
CHEBI:64198 CHEBI
CHEMBL1597 ChEMBL_ID
3080 PUBCHEM_CID
DB06782 DRUGBANK_ID
D004112 MESH_DESCRIPTOR_UI
1614 INN_ID
0CPP32S55X UNII
3445 RXNORM
4606 MMSL
d01401 MMSL
001087 NDDF
13664004 SNOMEDCT_US
387077001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BAL HUMAN PRESCRIPTION DRUG LABEL 1 17478-526 INJECTION 100 mg INTRAMUSCULAR NDA 16 sections
BAL HUMAN PRESCRIPTION DRUG LABEL 1 17478-526 INJECTION 100 mg INTRAMUSCULAR NDA 16 sections