ethanol Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
1076 64-17-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alcohol
  • ethanol
  • ethyl alcohol
  • grain alcohol
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
  • Molecular weight: 46.07
  • Formula: C2H6O
  • CLOGP: -0.24
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: 1.10
  • ROTB: 0

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 17, 1946 FDA B BRAUN

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 13756.01 74.74 3006 6883 28108 3347862
Toxicity to various agents 8831.19 74.74 2293 7596 44761 3331209
Drug abuse 7444.18 74.74 1676 8213 16654 3359316
Cardio-respiratory arrest 3214.64 74.74 831 9058 14609 3361361
Intentional overdose 3186.89 74.74 823 9066 14402 3361568
Respiratory arrest 2706.42 74.74 682 9207 10686 3365284
Poisoning 2576.54 74.74 564 9325 4548 3371422
Cardiac arrest 2402.83 74.74 751 9138 26568 3349402
Overdose 2370.59 74.74 783 9106 33195 3342775
Death 2245.17 74.74 1145 8744 151179 3224791
Intentional product misuse 2221.93 74.74 597 9292 12104 3363866
Suicide attempt 1933.92 74.74 562 9327 15285 3360685
Exposure via ingestion 1135.08 74.74 232 9657 1261 3374709
Drug hypersensitivity 1093.67 74.74 451 9438 35229 3340741
Alcohol poisoning 940.70 74.74 178 9711 593 3375377
Alcohol use 753.41 74.74 163 9726 1208 3374762
Alcohol abuse 709.86 74.74 138 9751 549 3375421
Coma 520.26 74.74 198 9691 12354 3363616
Somnolence 469.86 74.74 244 9645 31960 3344010
Substance abuse 344.20 74.74 84 9805 1108 3374862
Intentional self-injury 332.13 74.74 113 9776 5072 3370898
Hypotension 328.86 74.74 226 9663 49288 3326682
Poisoning deliberate 319.94 74.74 77 9812 954 3375016
Tachycardia 289.46 74.74 159 9730 23212 3352758
Blood alcohol increased 278.96 74.74 55 9834 238 3375732
Aggression 242.78 74.74 112 9777 11273 3364697
Agitation 238.23 74.74 132 9757 19574 3356396
Unresponsive to stimuli 232.92 74.74 98 9791 7910 3368060
Alcohol interaction 222.30 74.74 50 9839 449 3375521
Metabolic acidosis 217.77 74.74 96 9793 8682 3367288
Accidental death 204.89 74.74 49 9840 589 3375381
Loss of consciousness 204.42 74.74 136 9753 28011 3347959
Suicidal ideation 193.37 74.74 111 9778 17594 3358376
Vomiting 182.52 74.74 209 9680 89322 3286648
Accidental overdose 180.26 74.74 79 9810 7039 3368931
Alcoholism 170.60 74.74 44 9845 734 3375236
Drug dependence 170.12 74.74 66 9823 4310 3371660
Intentional product use issue 159.92 74.74 51 9838 1859 3374111
Seizure 154.40 74.74 133 9756 40267 3335703
Respiratory depression 153.21 74.74 59 9830 3775 3372195
Depressed level of consciousness 150.05 74.74 81 9808 11384 3364586
Sopor 143.58 74.74 56 9833 3708 3372262
Pulmonary oedema 133.52 74.74 76 9813 11835 3364135
Hepatic failure 133.12 74.74 73 9816 10579 3365391
Electrocardiogram QT prolonged 132.21 74.74 73 9816 10722 3365248
Drug withdrawal syndrome 131.58 74.74 75 9814 11710 3364260
Drug abuser 131.32 74.74 48 9841 2655 3373315
Asphyxia 124.93 74.74 40 9849 1476 3374494
Environmental exposure 123.45 74.74 23 9866 68 3375902
Drug interaction 122.71 74.74 125 9764 46687 3329283
Aspiration 120.35 74.74 46 9843 2882 3373088
Drug use disorder 117.55 74.74 34 9855 884 3375086
Road traffic accident 116.69 74.74 58 9831 6868 3369102
Mydriasis 113.12 74.74 44 9845 2890 3373080
Medication error 112.63 74.74 68 9821 11803 3364167
Sinus tachycardia 110.14 74.74 50 9839 4835 3371135
Rhabdomyolysis 106.86 74.74 73 9816 15656 3360314
Pulmonary congestion 104.50 74.74 42 9847 3008 3372962
Alcohol withdrawal syndrome 104.01 74.74 25 9864 307 3375663
Amnesia 103.20 74.74 62 9827 10664 3365306
Accidental exposure to product 98.50 74.74 46 9843 4746 3371224
Drug administration error 95.31 74.74 49 9840 6227 3369743
Dysarthria 93.49 74.74 56 9833 9578 3366392
Pneumonia aspiration 89.70 74.74 49 9840 7039 3368931
Drug level increased 88.40 74.74 42 9847 4503 3371467
Mental status changes 88.27 74.74 55 9834 10092 3365878
Blood ethanol increased 88.16 74.74 18 9871 96 3375874
Confusional state 87.95 74.74 95 9794 37903 3338067
Brain oedema 85.95 74.74 39 9850 3765 3372205
Drug screen positive 85.41 74.74 32 9857 1896 3374074
Shock 85.15 74.74 47 9842 6890 3369080
Miosis 82.81 74.74 32 9857 2064 3373906
Homicide 82.73 74.74 22 9867 415 3375555
Acidosis 81.52 74.74 34 9855 2676 3373294
Delirium 80.76 74.74 51 9838 9577 3366393
Acute hepatic failure 79.88 74.74 38 9851 4085 3371885
Lethargy 78.87 74.74 58 9831 13957 3362013

Pharmacologic Action:

SourceCodeDescription
ATC D08AX08 DERMATOLOGICALS
ANTISEPTICS AND DISINFECTANTS
ANTISEPTICS AND DISINFECTANTS
Other antiseptics and disinfectants
ATC V03AB16 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Antidotes
ATC V03AZ01 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Nerve depressants
CHEBI has role CHEBI:48218 antiseptic drug
CHEBI has role CHEBI:48354 polar solvent
CHEBI has role CHEBI:35488 central nervous system depressant
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000891 Anti-Infective Agents, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D012997 Solvents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Antiseptic preparation indication 261276004

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA A receptor alpha-4/beta-2/delta Ion channel WOMBAT-PK
Glycine receptor subunit alpha-2 Ion channel WOMBAT-PK
Glycine receptor subunit alpha-1 Ion channel WOMBAT-PK
Glutamate receptor ionotropic, NMDA 3A Ion channel WOMBAT-PK

External reference:

IDSource
CHEBI:16236 CHEBI
2299 IUPHAR_LIGAND_ID
4017736 VUID
N0000146104 NUI
C0001962 UMLSCUI
D06542 KEGG_DRUG
CHEMBL545 ChEMBL_ID
3K9958V90M UNII
DB00898 DRUGBANK_ID
448 RXNORM
4693 MMSL
d03162 MMSL
10010 MMSL
9888 MMSL
4017424 VANDF
4017736 VANDF
419442005 SNOMEDCT_US
N0000145812 NDFRT
N0000146104 NDFRT
N0000007432 NDFRT
002464 NDDF
001539 NDDF
398624005 SNOMEDCT_US
D000431 MESH_DESCRIPTOR_UI
702 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TRISEPTIN HUMAN OTC DRUG LABEL 1 0064-1050 LOTION 0.70 mL TOPICAL OTC monograph not final 9 sections
SURGICEPT HUMAN OTC DRUG LABEL 1 0064-1080 SOLUTION 0.75 mL TOPICAL OTC monograph not final 10 sections
Lupaneta Pack HUMAN PRESCRIPTION DRUG LABEL 3 0074-1052 KIT 0.70 mL None NDA 17 sections
Humphreys Alcoholado Maravilla HUMAN OTC DRUG LABEL 1 0219-2020 LIQUID 70 mL TOPICAL OTC monograph not final 13 sections
Decolorized Iodine HUMAN OTC DRUG LABEL 1 0295-1183 LIQUID 0.48 mL TOPICAL OTC MONOGRAPH FINAL 9 sections
SeptoSan HUMAN OTC DRUG LABEL 1 0362-6000 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
SeptoSan HUMAN OTC DRUG LABEL 1 0362-6001 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
SeptoSan HUMAN OTC DRUG LABEL 1 0362-6002 LIQUID 60 L TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Iodine HUMAN OTC DRUG LABEL 2 0363-0088 LIQUID 470 mg TOPICAL OTC monograph not final 12 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0370 GEL 70 mL TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0469 GEL 545 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0596 GEL 567 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0643 GEL 558 mg TOPICAL OTC monograph not final 11 sections
Crisp Apple Hand Sani HUMAN OTC DRUG LABEL 1 0363-0663 LIQUID 585 g TOPICAL OTC monograph not final 13 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0826 GEL 567 mg TOPICAL OTC monograph not final 12 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0363-0876 LIQUID 610 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0898 GEL 567 mg TOPICAL OTC monograph not final 11 sections
Advanced Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0952 GEL 700 mg TOPICAL OTC monograph not final 12 sections
Hand Sanitizer HUMAN OTC DRUG LABEL 1 0363-0984 GEL 567 mg TOPICAL OTC monograph not final 12 sections
Well at Walgreens HUMAN OTC DRUG LABEL 1 0363-9300 LIQUID 70 mL TOPICAL OTC monograph not final 11 sections
WALGREENS INSTANT HAND SANITIZER HUMAN OTC DRUG LABEL 1 0363-9320 SPRAY 62 mL TOPICAL OTC monograph not final 10 sections
Ethyl Rubbing Alcohol HUMAN OTC DRUG LABEL 1 0395-0040 LIQUID 700 mg TOPICAL OTC monograph not final 13 sections
Humco Iodides Tincture HUMAN OTC DRUG LABEL 1 0395-1207 LIQUID 0.45 mL TOPICAL OTC monograph not final 13 sections
Iodine Tincture Mild HUMAN OTC DRUG LABEL 2 0395-1213 LIQUID 470 mg TOPICAL OTC monograph not final 9 sections
Humco Strong Iodine Tincture HUMAN OTC DRUG LABEL 3 0395-1219 LIQUID 850 mg TOPICAL OTC monograph not final 12 sections
Strong Iodine Tincture HUMAN OTC DRUG LABEL 1 0395-1220 LIQUID 850 mg TOPICAL OTC monograph not final 12 sections
Iodides Tincture HUMAN OTC DRUG LABEL 1 0395-9117 LIQUID 0.45 mL TOPICAL OTC monograph not final 13 sections
Instant Hand Sanitizer HUMAN OTC DRUG LABEL 1 0404-5988 GEL 665 mL TOPICAL OTC monograph not final 8 sections
Instant Hand Sanitizer HUMAN OTC DRUG LABEL 1 0404-5991 GEL 665 mL TOPICAL OTC monograph not final 8 sections
STING RELIEF PAD HUMAN OTC DRUG LABEL 1 0498-0733 SWAB 0.50 mL TOPICAL OTC monograph not final 8 sections