benorilate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
310 5003-48-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benorilate
  • benoral
  • benortan
  • benorylate
  • fenasprate
  • quinexin
  • Molecular weight: 313.31
  • Formula: C17H15NO5
  • CLOGP: 2.15
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 81.70
  • ALOGS: -4.35
  • ROTB: 6

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
fu (Fraction unbound in plasma) 0.25 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1,ZAP70 61
kinase-selectivity-class ACVR2A,AXL,BRAF,CDK9,DDR1,ERBB2,GRK2,MAP2K6,MAPK7,MARK4,MTOR,PDK4,SIK2,STK33,TEK,TTK 16
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BA10 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
MeSH PA D000700 Analgesics
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018689 Sensory System Agents
MeSH PA D018712 Analgesics, Non-Narcotic
CHEBI has role CHEBI:35480 analgesic

Related Drugs by ATC class:

N02BA Salicylic acid and derivatives 11 drugs
acetylsalicylic acidaloxiprincarbasalate calciumdiflunisaldipyrocetylethenzamideguacetisalmagnesium salicylatesalicylamidesalicylic acidsalsalate

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07291 KEGG_DRUG
1372 RXNORM
C0005011 UMLSCUI
CHEBI:135340 CHEBI
CHEMBL162036 ChEMBL_ID
DB13657 DRUGBANK_ID
C084830 MESH_SUPPLEMENTAL_RECORD_UI
2297 INN_ID
W1QX9DV96G UNII
21102 PUBCHEM_CID
003933 NDDF
354058001 SNOMEDCT_US
391819000 SNOMEDCT_US

Pharmaceutical products:

None