salicylic acid indications/contra

Stem definitionDrug idCAS RN
analgesic anti-inflammatory 2416 69-72-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • choline salicylate
  • choline subsalicylate
  • salicylic acid
  • 2-Carboxyphenol
  • 2-Hydroxybenzenecarboxylic acid
  • 2-Hydroxybenzoic acid
  • imidazole salicylate
  • sodium salicylate
  • morpholine salicylate
  • potassium salicylate
A compound obtained from the bark of the white willow and wintergreen leaves. It has bacteriostatic, fungicidal, and keratolytic actions.
  • Molecular weight: 138.12
  • Formula: C7H6O3
  • CLOGP: 2.19
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 57.53
  • ALOGS: -1.09
  • ROTB: 1

Drug dosage:

DoseUnitRoute
3 g O
3 g O
7 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1898 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 185.72 57.65 47 190 35633 3349989
Completed suicide 166.48 57.65 42 195 31072 3354550
Toxicity to various agents 144.62 57.65 41 196 47013 3338609
Soft tissue necrosis 65.69 57.65 9 228 210 3385412

Pharmacologic Action:

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SourceCodeDescription
ATC D01AE12 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
ATC N02BA03 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA04 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA08 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA12 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC N02BA16 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Salicylic acid and derivatives
ATC S01BC08 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Antiinflammatory agents, non-steroids
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:50176 keratolytic drug
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D000935 Antifungal Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D016861 Cyclooxygenase Inhibitors
MeSH PA D003879 Dermatologic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D007641 Keratolytic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Pain indication 22253000
Greasy skin indication 42273000
Seborrheic dermatitis indication 50563003 DOID:8741
Allergic rhinitis indication 61582004
Verruca plantaris indication 63440008 DOID:13775
Rheumatoid arthritis indication 69896004 DOID:7148
Common cold indication 82272006 DOID:10459
Tinea corporis indication 84849002 DOID:12179
Acne vulgaris indication 88616000
Pityriasis simplex indication 200767005
Disorder of keratinization indication 277905003
Fever indication 386661006
Hyperkeratosis indication 396228006
Osteoarthritis indication 396275006 DOID:381
Synovitis indication 416209007 DOID:2703
Calluses and Corns indication
Crohn's disease off-label use 34000006
Tendinitis off-label use 34840004 DOID:971
Rheumatic fever off-label use 58718002 DOID:1586
Ulcerative colitis off-label use 64766004 DOID:8577
Tenosynovitis off-label use 67801009 DOID:970
Juvenile rheumatoid arthritis off-label use 410795001
Itching of skin off-label use 418363000

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.81 acidic
pKa2 12.79 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 14 Enzyme Ki 4.30 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 4.95 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 4.09 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.10 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.06 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 4.92 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.15 CHEMBL
Salicylic acid-binding protein 2 Enzyme WOMBAT-PK
Carbonic anhydrase 13 Enzyme Ki 4.17 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 5.14 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 4 CHEMBL
Solute carrier family 22 member 20 Transporter Ki 4.36 CHEMBL

External reference:

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IDSource
CHEBI:16914 CHEBI
4306 IUPHAR_LIGAND_ID
4018663 VUID
N0000146974 NUI
C0036079 UMLSCUI
D00097 KEGG_DRUG
CHEMBL424 ChEMBL_ID
4JVD4X01MJ UNII
5485 INN_ID
36364-49-5 SECONDARY_CAS_RN
DB00936 DRUGBANK_ID
4018663 VANDF
9170 MMSL
9525 RXNORM
5439 MMSL
387253001 SNOMEDCT_US
46741005 SNOMEDCT_US
N0000006693 NDFRT
N0000146974 NDFRT
001951 NDDF
CHEMBL447868 ChEMBL_ID
CHEMBL2104095 ChEMBL_ID
CHEMBL2104788 ChEMBL_ID
CHEMBL3707214 ChEMBL_ID
D012980 MESH_DESCRIPTOR_UI
D020156 MESH_DESCRIPTOR_UI
C015075 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL3707342 ChEMBL_ID
338 PUBCHEM_CID
SAL PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
SKIN MEDICA Purifying Foaming Wash HUMAN OTC DRUG LABEL 1 0023-4948 LIQUID 20 mg TOPICAL OTC monograph final 8 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0113-0137 LIQUID 0.17 mg TOPICAL OTC monograph final 9 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0113-0138 LIQUID 0.17 mg TOPICAL OTC monograph final 9 sections
AcneFree Sensitive HUMAN OTC DRUG LABEL 2 0187-1612 KIT 15 mg None OTC monograph final 10 sections
AcneFree HUMAN OTC DRUG LABEL 1 0187-1638 LIQUID 2 g TOPICAL OTC monograph final 9 sections
AcneFree HUMAN OTC DRUG LABEL 1 0187-1639 SOLUTION 20 mg TOPICAL OTC monograph final 9 sections
AcneFree Body Clearing HUMAN OTC DRUG LABEL 1 0187-5010 SPRAY 2.84 g TOPICAL OTC MONOGRAPH FINAL 9 sections
Ambi Even and Clear Exfoliating Wash HUMAN OTC DRUG LABEL 1 0187-5471 CREAM 5 mg TOPICAL OTC monograph final 9 sections
Ambi Even and Clear Foaming Cleanser HUMAN OTC DRUG LABEL 1 0187-5472 LIQUID 5 mg TOPICAL OTC MONOGRAPH FINAL 9 sections
CLENZIDERM DAILY CARE FOAMING CLEANSER HUMAN OTC DRUG LABEL 1 0187-6100 LIQUID 20 mg TOPICAL OTC monograph final 9 sections
CLENZIDERM PORE THERAPY HUMAN OTC DRUG LABEL 1 0187-6102 SOLUTION 20 mg TOPICAL OTC monograph final 10 sections
CLENZIDERM M.D. SYSTEM HUMAN OTC DRUG LABEL 3 0187-6103 KIT 20 mg None OTC monograph final 10 sections
CLENZIDERM M.D. SYSTEM HUMAN OTC DRUG LABEL 3 0187-6103 KIT 20 mg None OTC monograph final 10 sections
Benzac HUMAN OTC DRUG LABEL 1 0299-3674 GEL 0.50 g TOPICAL OTC monograph final 8 sections
Benzac HUMAN OTC DRUG LABEL 1 0299-3676 SOLUTION 0.50 g TOPICAL OTC monograph final 9 sections
Benzac HUMAN OTC DRUG LABEL 1 0299-3677 GEL 2 g TOPICAL OTC monograph final 9 sections
Almay Clear Complexion Liquid Makeup for Oily Skin HUMAN OTC DRUG LABEL 1 0311-0715 LIQUID 0.50 mg TOPICAL OTC monograph final 7 sections
Almay Clear Complexion 4 in 1 Pressed Powder HUMAN OTC DRUG LABEL 1 0311-0717 POWDER 0.60 mg TOPICAL OTC monograph final 8 sections
Almay Clear Complexion Blemish Healing Spot Concealer HUMAN OTC DRUG LABEL 1 0311-0718 LIQUID 0.01 g TOPICAL OTC monograph final 8 sections
Salicylic acid HUMAN OTC DRUG LABEL 1 0363-0017 CREAM 5.05 mg TOPICAL OTC monograph final 10 sections
Charcoal Blackhead Clearing Scrub HUMAN OTC DRUG LABEL 1 0363-0027 CREAM 20.60 mg TOPICAL OTC monograph final 12 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0363-0203 PATCH 40 mg TOPICAL OTC monograph final 9 sections
Salicylic Acid HUMAN OTC DRUG LABEL 1 0363-0219 GEL 0.17 g TOPICAL OTC monograph final 9 sections
Oil-Free Daily Face HUMAN OTC DRUG LABEL 1 0363-0480 CREAM 2 g TOPICAL OTC monograph final 8 sections
Walgreens Oil-Free Acne Wash HUMAN OTC DRUG LABEL 1 0363-0536 SOLUTION 2 g TOPICAL OTC monograph final 9 sections
Walgreens Medicated Callus Removers HUMAN OTC DRUG LABEL 1 0363-0819 DISC 17.67 mg TOPICAL OTC MONOGRAPH FINAL 10 sections
WALGREENS HUMAN OTC DRUG LABEL 1 0363-0828 LIQUID 20 mg TOPICAL OTC monograph final 8 sections
WELL AT WALGREENS HUMAN OTC DRUG LABEL 1 0363-0829 LIQUID 20 mg TOPICAL OTC monograph final 8 sections
Well at Walgreens Blemish and Blackhead Control Apricot HUMAN OTC DRUG LABEL 1 0363-0830 LIQUID 0.02 g TOPICAL OTC monograph final 8 sections
Charcoal Blackhead Clearing Scrub HUMAN OTC DRUG LABEL 1 0363-0910 CREAM 20.60 mg TOPICAL OTC monograph final 12 sections