ergocalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2838 50-14-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ergocalciferol
  • vitamin D2
  • calciferol
  • ercalciol
  • ergorone
  • Molecular weight: 396.66
  • Formula: C28H44O
  • CLOGP: 9.39
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -5.96
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.86 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 11, 1941 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 997.33 10.22 326 486142 246924 62755630
Completed suicide 720.72 10.22 124 486344 145549 62857005
Drug interaction 439.52 10.22 672 485796 228459 62774095
Drug abuse 435.46 10.22 31 486437 72487 62930067
Intentional overdose 396.93 10.22 50 486418 74102 62928452
Drug ineffective 370.43 10.22 5713 480755 1039052 61963502
Multiple sclerosis relapse 348.41 10.22 986 485482 47492 62955062
Overdose 325.98 10.22 243 486225 114835 62887719
Product dose omission issue 312.70 10.22 2952 483516 231361 62771193
Acute kidney injury 305.31 10.22 1017 485451 262398 62740156
Muscle spasms 270.85 10.22 2086 484382 154064 62848490
Pemphigus 264.65 10.22 639 485829 183087 62819467
Back pain 242.57 10.22 3090 483378 261055 62741499
Contraindicated product administered 222.57 10.22 885 485583 216763 62785791
Systemic lupus erythematosus 211.40 10.22 853 485615 208065 62794489
Fatigue 208.25 10.22 8542 477926 879486 62123068
Exposure during pregnancy 207.01 10.22 563 485905 154984 62847570
Headache 205.58 10.22 6323 480145 626918 62375636
Cardio-respiratory arrest 196.63 10.22 107 486361 59852 62942702
Thrombocytopenia 190.90 10.22 561 485907 150596 62851958
Depressed level of consciousness 187.78 10.22 122 486346 61956 62940598
Hypotension 186.06 10.22 1273 485195 271331 62731223
Glossodynia 183.68 10.22 726 485742 178150 62824404
Hypoaesthesia 183.54 10.22 2036 484432 166357 62836197
Cardiac arrest 178.59 10.22 270 486198 92275 62910279
Suicide attempt 174.58 10.22 127 486341 60791 62941763
Hand deformity 170.92 10.22 636 485832 158821 62843733
Maternal exposure during pregnancy 169.48 10.22 990 485478 219072 62783482
Multiple organ dysfunction syndrome 168.33 10.22 114 486354 56638 62945916
Febrile neutropenia 167.31 10.22 416 486052 118033 62884521
Hyponatraemia 159.61 10.22 391 486077 111509 62891045
Infective pulmonary exacerbation of cystic fibrosis 159.35 10.22 261 486207 8556 62993998
Pain in extremity 154.47 10.22 3473 482995 328013 62674541
Multiple sclerosis 154.35 10.22 474 485994 23898 62978656
Hepatic function abnormal 153.01 10.22 47 486421 37095 62965459
White blood cell count decreased 146.14 10.22 1670 484798 137434 62865120
Feeling abnormal 145.06 10.22 1757 484711 146635 62855919
Diarrhoea 143.21 10.22 6773 479695 708593 62293961
Drug intolerance 141.56 10.22 1597 484871 307064 62695490
Drug reaction with eosinophilia and systemic symptoms 140.86 10.22 42 486426 33794 62968760
Infusion related reaction 137.28 10.22 1211 485257 244310 62758244
Synovitis 137 10.22 854 485614 186064 62816490
Bone pain 136.84 10.22 800 485668 53841 62948713
Influenza like illness 135.45 10.22 927 485541 65897 62936657
Electrocardiogram QT prolonged 133.93 10.22 155 486313 59375 62943179
Hyperkalaemia 130.95 10.22 133 486335 54070 62948484
Insomnia 129.38 10.22 2343 484125 212909 62789645
Pancytopenia 127.30 10.22 353 486115 96580 62905974
Cardiac failure 125.92 10.22 313 486155 88829 62913725
Memory impairment 125.86 10.22 1287 485181 102971 62899583
Lactic acidosis 124.55 10.22 69 486399 38218 62964336
Fall 123.26 10.22 3904 482564 388430 62614124
Metabolic acidosis 120.22 10.22 101 486367 44968 62957586
Muscle spasticity 117.33 10.22 401 486067 21393 62981161
Night sweats 117.29 10.22 707 485761 48107 62954447
Septic shock 114.96 10.22 209 486259 66420 62936134
General physical health deterioration 114.04 10.22 990 485478 200412 62802142
Intentional self-injury 112.31 10.22 29 486439 25658 62976896
Asthenia 110.91 10.22 3780 482688 379824 62622730
Neutropenia 110.67 10.22 835 485633 174170 62828384
Hepatocellular injury 110.38 10.22 36 486432 27345 62975209
Burning sensation 109.22 10.22 753 485715 53654 62948900
Death 108.99 10.22 2117 484351 372264 62630290
Gastrooesophageal reflux disease 108.55 10.22 1166 485302 94473 62908081
Ear pain 107.34 10.22 554 485914 35564 62966990
Hypokalaemia 106.69 10.22 421 486047 103383 62899171
Pericarditis 103.87 10.22 587 485881 130992 62871562
Bradycardia 103.51 10.22 257 486211 72970 62929584
Paraesthesia 103.02 10.22 1733 484735 155233 62847321
Respiratory failure 101.60 10.22 418 486050 101440 62901114
Full blood count decreased 101.44 10.22 432 486036 25592 62976962
Carpal tunnel syndrome 100.88 10.22 370 486098 20447 62982107
Body height decreased 100.46 10.22 232 486236 9846 62992708
Rhabdomyolysis 100.42 10.22 113 486355 43838 62958716
Vitamin D decreased 100.15 10.22 234 486234 10008 62992546
Gait disturbance 99.73 10.22 1964 484504 181214 62821340
Mucosal inflammation 99.42 10.22 128 486340 46800 62955754
Wound 98.53 10.22 789 485679 162474 62840080
Psoriasis 97.22 10.22 1057 485411 85900 62916654
Hepatic cytolysis 94.19 10.22 6 486462 15401 62987153
Sensitisation 92.82 10.22 122 486346 3264 62999290
Vitamin D deficiency 92.49 10.22 275 486193 13617 62988937
Sinusitis 92.41 10.22 2332 484136 224321 62778233
COVID-19 91.56 10.22 1294 485174 111809 62890745
Blood test abnormal 90.74 10.22 295 486173 15334 62987220
Anti-cyclic citrullinated peptide antibody positive 90.34 10.22 521 485947 115691 62886863
Agranulocytosis 88.18 10.22 41 486427 25093 62977461
Sedation 87.34 10.22 101 486367 38708 62963846
Hepatotoxicity 87.09 10.22 93 486375 36948 62965606
Coma 86.29 10.22 232 486236 64132 62938422
Treatment failure 85.29 10.22 1045 485423 197998 62804556
Urinary tract infection 83.29 10.22 2635 483833 262049 62740505
Constipation 82.63 10.22 2283 484185 222660 62779894
Confusional state 82.37 10.22 1294 485174 235086 62767468
Drug hypersensitivity 79.70 10.22 1793 484675 308894 62693660
Blood calcium increased 79.05 10.22 202 486266 9148 62993406
Cholestasis 78.46 10.22 66 486402 29368 62973186
Shock 78.19 10.22 41 486427 23422 62979132
Psoriatic arthropathy 78.10 10.22 1057 485411 90463 62912091
Rhinorrhoea 77.91 10.22 807 485661 64770 62937784
Limb discomfort 77.60 10.22 440 486028 29276 62973278
Rash maculo-papular 77.34 10.22 78 486390 31818 62970736
Neutropenic sepsis 76.95 10.22 16 486452 16422 62986132
Tachycardia 76.94 10.22 559 485909 117597 62884957
Swelling 76.79 10.22 1568 484900 273810 62728744
Influenza 76.37 10.22 1214 485254 107508 62895046
Sleep apnoea syndrome 75.84 10.22 431 486037 28702 62973852
Cytomegalovirus infection 75.35 10.22 33 486435 20919 62981635
Dry skin 75.32 10.22 716 485752 56171 62946383
Full blood count abnormal 75.31 10.22 458 486010 31259 62971295
Polycystic ovaries 74.99 10.22 128 486340 4343 62998211
Asthma 74.98 10.22 1384 485084 126177 62876377
Hip fracture 74.08 10.22 432 486036 29042 62973512
Myelosuppression 73.85 10.22 45 486423 23658 62978896
Leukopenia 72.88 10.22 324 486144 76966 62925588
Malignant neoplasm progression 72.85 10.22 352 486116 81769 62920785
Ejection fraction 72.73 10.22 91 486377 2315 63000239
Abdominal pain upper 72.39 10.22 2083 484385 204361 62798193
Altered state of consciousness 71.75 10.22 53 486415 25177 62977377
Muscular weakness 71.39 10.22 1326 485142 121027 62881527
Sinus disorder 71.15 10.22 374 486094 24179 62978375
Sepsis 70.96 10.22 790 485678 152333 62850221
Respiratory arrest 70.23 10.22 88 486380 32557 62969997
Discomfort 70.08 10.22 883 485585 166491 62836063
Neuroleptic malignant syndrome 69.98 10.22 6 486462 12050 62990504
Hepatic failure 69.76 10.22 103 486365 35553 62967001
Anaemia 69.52 10.22 1714 484754 291716 62710838
Cerebral infarction 69.51 10.22 49 486419 23844 62978710
Bone marrow failure 69.47 10.22 73 486395 29217 62973337
Poisoning 69.17 10.22 11 486457 13689 62988865
Weight decreased 68.52 10.22 2681 483787 274117 62728437
Dry mouth 67.55 10.22 902 485566 76961 62925593
Spinal fracture 67.15 10.22 298 486170 17973 62984581
Taste disorder 66.34 10.22 243 486225 13419 62989135
Toxic skin eruption 65.84 10.22 10 486458 12875 62989679
Anaphylactic shock 65.48 10.22 51 486417 23582 62978972
Serotonin syndrome 65.24 10.22 74 486394 28608 62973946
Respiratory depression 64.93 10.22 13 486455 13702 62988852
Arthropathy 64.81 10.22 1339 485129 233453 62769101
Renal failure 64.05 10.22 584 485884 117068 62885486
Stevens-Johnson syndrome 64.01 10.22 58 486410 24892 62977662
Agitation 63.54 10.22 239 486229 59518 62943036
Angioedema 63.45 10.22 174 486294 47791 62954763
Foetal exposure during pregnancy 62.85 10.22 92 486376 31870 62970684
Acute hepatic failure 62.61 10.22 31 486437 18296 62984258
Chills 62.46 10.22 1218 485250 112160 62890394
Off label use 62.28 10.22 5986 480482 668476 62334078
Myalgia 62.16 10.22 1516 484952 145013 62857541
Jaundice 61.73 10.22 80 486388 29171 62973383
Torsade de pointes 60.46 10.22 14 486454 13337 62989217
Hypoglycaemia 60.19 10.22 246 486222 59819 62942735
Therapeutic product effect decreased 59.63 10.22 1081 485387 192106 62810448
Sleep disorder due to a general medical condition 59.37 10.22 217 486251 11971 62990583
Bronchitis 59.28 10.22 1313 485155 123622 62878932
Osteopenia 59.14 10.22 304 486164 19481 62983073
Neurotoxicity 57.65 10.22 29 486439 16961 62985593
Circulatory collapse 57.48 10.22 50 486418 21888 62980666
Interstitial lung disease 57.47 10.22 261 486207 61647 62940907
Ejection fraction decreased 57.19 10.22 52 486416 22280 62980274
Drug resistance 56.85 10.22 55 486413 22878 62979676
Encephalopathy 56.58 10.22 133 486335 38487 62964067
Seasonal allergy 55.89 10.22 312 486156 20638 62981916
Depression 55.57 10.22 1932 484536 194560 62807994
Osteoarthritis 55.51 10.22 1033 485435 94310 62908244
Premature baby 54.64 10.22 47 486421 20688 62981866
Nephrolithiasis 54.37 10.22 526 485942 41458 62961096
Sedation complication 54.27 10.22 19 486449 13803 62988751
Pyrexia 54.24 10.22 3000 483468 467478 62535076
Atypical femur fracture 53.91 10.22 124 486344 5248 62997306
Inappropriate schedule of product administration 53.63 10.22 1106 485362 102859 62899695
Pollakiuria 52.75 10.22 381 486087 27556 62974998
Toxic epidermal necrolysis 52.73 10.22 70 486398 25264 62977290
Ventricular fibrillation 52.65 10.22 13 486455 11854 62990700
Drug-induced liver injury 52.40 10.22 147 486321 40075 62962479
Gastrointestinal haemorrhage 52.37 10.22 385 486083 80791 62921763
Nasal congestion 52.23 10.22 749 485719 64911 62937643
Plasma cell myeloma 52.12 10.22 461 486007 35444 62967110
Fibromyalgia 51.30 10.22 884 485584 79536 62923018
Arthralgia 50.71 10.22 5044 481424 564666 62437888
Cardiogenic shock 50.57 10.22 38 486430 17894 62984660
Flatulence 50.09 10.22 445 486023 34257 62968297
Acute respiratory distress syndrome 50.04 10.22 64 486404 23470 62979084
Macular degeneration 49.88 10.22 339 486129 24037 62978517
Myoclonus 49.61 10.22 30 486438 15838 62986716
Acute generalised exanthematous pustulosis 49.55 10.22 12 486456 11087 62991467
Ventricular tachycardia 49.43 10.22 48 486420 19931 62982623
Anaphylactic reaction 49.41 10.22 300 486168 65800 62936754
Glaucoma 49.41 10.22 280 486188 18625 62983929
Micturition urgency 49.27 10.22 174 486294 9437 62993117
Extrapyramidal disorder 49.25 10.22 20 486448 13264 62989290
Mycotic allergy 49.17 10.22 49 486419 961 63001593
Recalled product 48.84 10.22 57 486411 1346 63001208
Pneumocystis jirovecii pneumonia 48.79 10.22 35 486433 16879 62985675
Dizziness 48.46 10.22 3873 482595 426052 62576502
Melaena 48.24 10.22 100 486368 30265 62972289
Wrist fracture 47.98 10.22 219 486249 13368 62989186
Hepatic enzyme increased 47.29 10.22 1184 485284 201144 62801410
Liver function test abnormal 47.23 10.22 199 486269 47982 62954572
Hot flush 46.60 10.22 598 485870 50561 62951993
International normalised ratio increased 46.60 10.22 190 486278 46235 62956319
Neck pain 46.04 10.22 767 485701 68551 62934003
Mydriasis 45.98 10.22 17 486451 11939 62990615
Cough 45.96 10.22 2711 483757 290032 62712522
Rhinitis allergic 45.95 10.22 195 486273 11532 62991022
Cataract 45.45 10.22 651 485817 56402 62946152
Bone density abnormal 45.21 10.22 88 486380 3310 62999244
Ascites 45.20 10.22 160 486308 40568 62961986
Blood pressure diastolic abnormal 44.76 10.22 28 486440 14514 62988040
Medication error 44.70 10.22 227 486241 52057 62950497
Premature delivery 44.58 10.22 104 486364 30177 62972377
Pruritus 44.49 10.22 3279 483189 358174 62644380
Haematotoxicity 44.15 10.22 9 486459 9367 62993187
Face oedema 43.99 10.22 54 486414 20158 62982396
Balance disorder 43.18 10.22 897 485571 83525 62919029
Respiratory disorder 43.17 10.22 474 485994 38608 62963946
Aggression 42.99 10.22 71 486397 23427 62979127
Pre-existing condition improved 42.90 10.22 150 486318 8094 62994460
Loss of consciousness 42.66 10.22 642 485826 117479 62885075
Posterior reversible encephalopathy syndrome 42.53 10.22 42 486426 17303 62985251
Stress 42.36 10.22 737 485731 66430 62936124
Abortion induced 42.11 10.22 13 486455 10229 62992325
Cytokine release syndrome 42.11 10.22 29 486439 14285 62988269
Pleural effusion 41.94 10.22 484 485984 92726 62909828
Hypervitaminosis D 41.60 10.22 18 486450 71 63002483
Oropharyngeal pain 41.39 10.22 982 485486 93505 62909049
Blood creatine phosphokinase increased 41.30 10.22 109 486359 30321 62972233
Blood lactate dehydrogenase increased 41.23 10.22 71 486397 23045 62979509
Haematemesis 41.22 10.22 109 486359 30303 62972251
Peripheral swelling 41.20 10.22 2460 484008 263482 62739072
Hepatitis 41.09 10.22 161 486307 39627 62962927
Nasopharyngitis 40.92 10.22 2360 484108 251897 62750657
Migraine 40.78 10.22 1059 485409 102287 62900267
Bowel movement irregularity 40.70 10.22 110 486358 5154 62997400
Tooth disorder 40.60 10.22 361 486107 27796 62974758
Psychotic disorder 40.57 10.22 85 486383 25627 62976927
Illness 40.36 10.22 563 485905 48496 62954058
Disseminated intravascular coagulation 40.31 10.22 52 486416 18999 62983555
Coronary artery disease 40.22 10.22 121 486347 32256 62970298
Red blood cell count decreased 39.98 10.22 482 485986 40163 62962391
Transaminases increased 39.86 10.22 116 486352 31251 62971303
Body temperature increased 39.67 10.22 448 486020 36744 62965810
Lumbar vertebral fracture 39.62 10.22 116 486352 5694 62996860
Foot fracture 39.47 10.22 316 486152 23598 62978956
Accidental overdose 39.41 10.22 74 486394 23235 62979319
Seizure 39.09 10.22 748 485720 131886 62870668
Jaundice cholestatic 39.03 10.22 5 486463 7319 62995235
Blood pressure abnormal 39.00 10.22 224 486244 14974 62987580
Central nervous system lesion 38.74 10.22 173 486295 10462 62992092
Rib fracture 38.61 10.22 301 486167 22296 62980258
Premature labour 38.59 10.22 24 486444 12480 62990074
Neuropathy peripheral 38.46 10.22 1142 485326 112525 62890029
Labelled drug-drug interaction medication error 38.29 10.22 28 486440 13371 62989183
Alanine aminotransferase increased 38.16 10.22 562 485906 103208 62899346
Wheezing 38.13 10.22 981 485487 94614 62907940
Stress fracture 38.13 10.22 141 486327 7822 62994732
Ischaemic stroke 38.01 10.22 49 486419 17908 62984646
Femur fracture 37.99 10.22 488 485980 41268 62961286
Cardiotoxicity 37.91 10.22 9 486459 8429 62994125
Injection site mass 37.90 10.22 259 486209 18397 62984157
Pathological fracture 37.85 10.22 151 486317 8683 62993871
Folliculitis 37.84 10.22 350 486118 69967 62932587
Injection site erythema 37.84 10.22 869 485599 82305 62920249
Ill-defined disorder 37.77 10.22 422 486046 81333 62921221
Abdominal distension 37.57 10.22 899 485569 85716 62916838
Cystic fibrosis 37.50 10.22 80 486388 3216 62999338
Bone loss 37.33 10.22 77 486391 3022 62999532
Lower limb fracture 37.26 10.22 315 486153 23906 62978648
Dysgeusia 37.21 10.22 533 485935 46177 62956377
Orthostatic hypotension 36.91 10.22 147 486321 36013 62966541
Injection site reaction 36.84 10.22 642 485826 57882 62944672
Musculoskeletal discomfort 36.84 10.22 250 486218 17717 62984837
Frequent bowel movements 36.79 10.22 302 486166 22720 62979834
Myocardial infarction 36.74 10.22 541 485927 99352 62903202
Febrile bone marrow aplasia 36.71 10.22 6 486462 7319 62995235
Erythema multiforme 36.59 10.22 16 486452 10153 62992401
Muscle injury 36.58 10.22 322 486146 65023 62937531
Therapy cessation 36.25 10.22 375 486093 30082 62972472
Lymphocyte count decreased 36.24 10.22 373 486095 29884 62972670
Suspected suicide 36.20 10.22 4 486464 6564 62995990
Anuria 36.17 10.22 26 486442 12525 62990029
Hypervitaminosis 36.02 10.22 13 486455 27 63002527
Aspartate aminotransferase increased 36.01 10.22 481 485987 89796 62912758
Diverticulitis 35.86 10.22 462 486006 39095 62963459
Hospitalisation 35.68 10.22 879 485589 84202 62918352
Skin discolouration 35.65 10.22 445 486023 37383 62965171
Thoracic vertebral fracture 35.55 10.22 96 486372 4496 62998058
Colitis ulcerative 35.33 10.22 330 486138 25761 62976793
Drug dependence 35.32 10.22 85 486383 24398 62978156
Hypertensive crisis 35.24 10.22 39 486429 15247 62987307
Bone lesion 35.04 10.22 112 486356 5769 62996785
Status epilepticus 34.97 10.22 39 486429 15194 62987360
Hernia 34.70 10.22 189 486279 12385 62990169
Tooth extraction 34.45 10.22 163 486305 10101 62992453
Dry eye 34.44 10.22 470 485998 40291 62962263
Injection site pain 34.14 10.22 1266 485202 128534 62874020
Injection site bruising 34.09 10.22 480 485988 41430 62961124
Cyanosis 34.03 10.22 48 486420 16887 62985667
Creatinine renal clearance decreased 34.00 10.22 45 486423 16263 62986291
Vision blurred 33.98 10.22 934 485534 90990 62911564
Dyspepsia 33.82 10.22 1024 485444 101172 62901382
Device expulsion 33.76 10.22 145 486323 34777 62967777
Blepharospasm 33.75 10.22 112 486356 5884 62996670
Upper limb fracture 33.71 10.22 255 486213 18713 62983841
Cystitis 33.46 10.22 600 485868 54391 62948163
JC polyomavirus test positive 33.28 10.22 48 486420 1405 63001149
Syncope 33.07 10.22 667 485801 116718 62885836
Blood pressure increased 32.91 10.22 1538 484930 160524 62842030
Drug level increased 32.74 10.22 79 486389 22657 62979897
Gamma-glutamyltransferase increased 32.47 10.22 142 486326 33889 62968665
Blood bilirubin increased 32.46 10.22 160 486308 36980 62965574
Haemodialysis 32.32 10.22 14 486454 8933 62993621
Generalised tonic-clonic seizure 32.19 10.22 114 486354 28902 62973652
Dystonia 32.15 10.22 35 486433 13784 62988770
Hair texture abnormal 32.14 10.22 88 486380 4155 62998399
Injection site pruritus 32.12 10.22 505 485963 44611 62957943
Mean cell haemoglobin concentration abnormal 31.98 10.22 17 486451 115 63002439
Vitamin D increased 31.85 10.22 33 486435 679 63001875
Respiratory tract congestion 31.85 10.22 240 486228 17592 62984962
Ankle fracture 31.71 10.22 240 486228 17615 62984939
Anxiety 31.57 10.22 2001 484467 215540 62787014
Bronchial neoplasm 31.53 10.22 28 486440 472 63002082
Gastrointestinal toxicity 31.51 10.22 10 486458 7731 62994823
Thrombosis 31.48 10.22 683 485785 64072 62938482
Blood parathyroid hormone increased 31.46 10.22 71 486397 2967 62999587
Foetal death 31.31 10.22 23 486445 10957 62991597
Disease progression 31.25 10.22 709 485759 122049 62880505
Gait inability 31.23 10.22 575 485893 52384 62950170
Road traffic accident 31.20 10.22 423 486045 36209 62966345
Ejection fraction abnormal 31.13 10.22 52 486416 1733 63000821
Blood 25-hydroxycholecalciferol increased 31.03 10.22 8 486460 0 63002554
Skin haemorrhage 30.80 10.22 156 486312 9938 62992616
Hyperglycaemia 30.77 10.22 191 486277 41676 62960878
Cardiac disorder 30.76 10.22 554 485914 50262 62952292
Intramedullary rod insertion 30.74 10.22 57 486411 2066 63000488
Surgery 30.71 10.22 415 486053 35497 62967057
Coagulopathy 30.69 10.22 70 486398 20474 62982080
Laboratory test abnormal 30.46 10.22 328 486140 26584 62975970
Hepatic enzyme abnormal 30.45 10.22 113 486355 6279 62996275
Bronchopulmonary aspergillosis 30.42 10.22 14 486454 8621 62993933
No adverse event 30.38 10.22 189 486279 41216 62961338
Drug eruption 30.35 10.22 115 486353 28579 62973975
Neuralgia 30.29 10.22 318 486150 25608 62976946
Hypomania 29.97 10.22 6 486462 6324 62996230
Helicobacter infection 29.93 10.22 515 485953 92270 62910284
Thyroid disorder 29.92 10.22 209 486259 14953 62987601
Tonsillar ulcer 29.80 10.22 22 486446 281 63002273
Peroneal nerve palsy 29.65 10.22 93 486375 4742 62997812
Contusion 29.62 10.22 1420 485048 148624 62853930
Hypoacusis 29.53 10.22 299 486169 23852 62978702
Hyperbilirubinaemia 29.38 10.22 26 486442 11288 62991266
Haemophagocytic lymphohistiocytosis 29.35 10.22 23 486445 10604 62991950
Immune system disorder 29.32 10.22 151 486317 9683 62992871
Bone density decreased 29.17 10.22 202 486266 14410 62988144
Sneezing 29.12 10.22 239 486229 17979 62984575
Hyperthermia 29.06 10.22 17 486451 9139 62993415
Inappropriate antidiuretic hormone secretion 28.96 10.22 46 486422 15416 62987138
Urine leukocyte esterase positive 28.90 10.22 76 486392 3503 62999051
Caesarean section 28.86 10.22 54 486414 16978 62985576
Dermatitis atopic 28.78 10.22 149 486319 9575 62992979
Abnormal faeces 28.77 10.22 100 486368 5380 62997174
Temperature regulation disorder 28.64 10.22 6 486462 6126 62996428
Urine abnormality 28.51 10.22 118 486350 6901 62995653
Multiple allergies 28.27 10.22 192 486276 13610 62988944
Bronchospasm 28.22 10.22 56 486412 17224 62985330
Nicotine dependence 28.14 10.22 31 486437 686 63001868
Shock haemorrhagic 27.86 10.22 21 486447 9874 62992680
Paraesthesia oral 27.82 10.22 247 486221 19009 62983545
Brain oedema 27.77 10.22 41 486427 14154 62988400
Pulmonary mass 27.75 10.22 280 486188 22316 62980238
Pulmonary embolism 27.73 10.22 681 485787 116003 62886551
Dry throat 27.69 10.22 114 486354 6651 62995903
Sinus congestion 27.51 10.22 235 486233 17888 62984666
Bronchial haemorrhage 27.50 10.22 28 486440 564 63001990
Electrocardiogram QRS complex prolonged 27.34 10.22 6 486462 5932 62996622
Tubulointerstitial nephritis 27.23 10.22 71 486397 19832 62982722
Delirium 27.00 10.22 252 486216 50289 62952265
Maternal drugs affecting foetus 26.94 10.22 4 486464 5238 62997316
Pancreatic neuroendocrine tumour 26.90 10.22 24 486444 407 63002147
Oxygen saturation decreased 26.89 10.22 497 485971 88088 62914466
Therapeutic response unexpected 26.78 10.22 240 486228 18519 62984035
Cerebral haemorrhage 26.50 10.22 133 486335 30596 62971958
Productive cough 26.49 10.22 653 485815 62555 62939999
Respiratory distress 26.48 10.22 152 486316 33799 62968755
Multiple-drug resistance 26.44 10.22 4 486464 5166 62997388
Vitamin B12 decreased 26.36 10.22 74 486394 3546 62999008
Gastrointestinal pain 26.35 10.22 146 486322 9630 62992924
Intervertebral disc degeneration 26.02 10.22 208 486260 15524 62987030
Bronchial disorder 25.80 10.22 40 486428 1250 63001304
Hypersensitivity 25.78 10.22 1912 484556 290773 62711781
Metastases to central nervous system 25.49 10.22 38 486430 13067 62989487
Transplant rejection 25.41 10.22 27 486441 10753 62991801
Thrombotic microangiopathy 25.40 10.22 26 486442 10535 62992019
Abortion spontaneous 25.35 10.22 235 486233 46960 62955594
Accidental exposure to product 25.15 10.22 116 486352 27289 62975265
Palmar-plantar erythrodysaesthesia syndrome 25.15 10.22 91 486377 22924 62979630
Unintended pregnancy 25.12 10.22 8 486460 6171 62996383
Nephrectomy 25.06 10.22 43 486425 1465 63001089
Disorientation 25.01 10.22 188 486280 39264 62963290
Nasal turbinate hypertrophy 24.91 10.22 30 486438 733 63001821
Parkinsonism 24.77 10.22 26 486442 10413 62992141
Post procedural hypothyroidism 24.65 10.22 19 486449 260 63002294
Schizophrenia 24.51 10.22 24 486444 9928 62992626
Gait spastic 24.35 10.22 19 486449 265 63002289
Miosis 24.28 10.22 13 486455 7340 62995214
Mean cell haemoglobin increased 24.28 10.22 63 486405 2880 62999674
Device use error 24.25 10.22 7 486461 5754 62996800
Oral pain 24.23 10.22 328 486140 28066 62974488
Coma scale abnormal 24.15 10.22 5 486463 5148 62997406
Infusion site pruritus 24.15 10.22 101 486367 5934 62996620
Left ventricular dysfunction 24.07 10.22 34 486434 11954 62990600
Skin exfoliation 24.04 10.22 464 486004 42638 62959916
Urticaria 24.02 10.22 1525 484943 164277 62838277
Sleep disorder due to general medical condition, insomnia type 23.93 10.22 270 486198 51947 62950607
Blister 23.88 10.22 785 485683 129029 62873525
Endometrial ablation 23.78 10.22 33 486435 931 63001623
Respiratory acidosis 23.48 10.22 11 486457 6704 62995850
COVID-19 immunisation 23.44 10.22 46 486422 1741 63000813
Malaise 23.44 10.22 3580 482888 412374 62590180
Bone giant cell tumour 23.40 10.22 9 486459 24 63002530
Deep vein thrombosis postoperative 23.19 10.22 158 486310 11211 62991343
Essential hypertension 23.17 10.22 88 486380 4945 62997609
Pathogen resistance 23.13 10.22 10 486458 6388 62996166
Device difficult to use 23.10 10.22 39 486429 12757 62989797
Back disorder 23.01 10.22 154 486314 10863 62991691
Nervousness 22.91 10.22 349 486119 30630 62971924
Flushing 22.90 10.22 745 485723 74342 62928212
Hypercalcaemia 22.88 10.22 324 486144 27998 62974556
Clostridium difficile infection 22.87 10.22 339 486129 29583 62972971
Renal impairment 22.85 10.22 509 485959 87846 62914708
Hypertransaminasaemia 22.85 10.22 11 486457 6598 62995956
Acute myeloid leukaemia 22.83 10.22 62 486406 17085 62985469
Haemodynamic instability 22.82 10.22 22 486446 9168 62993386
Toothache 22.67 10.22 236 486232 18963 62983591
Atrioventricular block complete 22.61 10.22 18 486450 8233 62994321
Crying 22.60 10.22 276 486192 23067 62979487
Akathisia 22.59 10.22 22 486446 9124 62993430
Degenerative bone disease 22.56 10.22 15 486453 160 63002394
Head discomfort 22.54 10.22 178 486290 13237 62989317
C-reactive protein increased 22.43 10.22 553 485915 94154 62908400
Eosinophilia 22.29 10.22 94 486374 22662 62979892
Appetite disorder 22.24 10.22 113 486355 7208 62995346
Osteomalacia 22.24 10.22 28 486440 717 63001837
Adrenal insufficiency 22.22 10.22 67 486401 17848 62984706
Pallor 22.18 10.22 140 486328 30428 62972126
Meralgia paraesthetica 22.18 10.22 22 486446 429 63002125
Sinus tachycardia 22.11 10.22 103 486365 24165 62978389
Acute coronary syndrome 22.09 10.22 27 486441 10099 62992455
Haematoma 22.04 10.22 166 486302 34654 62967900
Spinal operation 21.94 10.22 123 486345 8148 62994406
Stress cardiomyopathy 21.91 10.22 24 486444 9426 62993128
Foreign body in reproductive tract 21.76 10.22 28 486440 733 63001821
Muscle tightness 21.72 10.22 161 486307 11739 62990815
Autoimmune disorder 21.65 10.22 214 486254 16963 62985591
Injection site urticaria 21.63 10.22 183 486285 13890 62988664
Lip dry 21.62 10.22 197 486271 15273 62987281
Dyspnoea 21.58 10.22 4609 481859 656704 62345850
Secondary progressive multiple sclerosis 21.53 10.22 39 486429 1388 63001166
Eye infection 21.43 10.22 163 486305 11982 62990572
Unintentional medical device removal 21.41 10.22 10 486458 6105 62996449
Peritonitis 21.39 10.22 64 486404 17090 62985464
Drug ineffective for unapproved indication 21.27 10.22 163 486305 33900 62968654
Duodenal ulcer perforation 21.26 10.22 507 485961 86702 62915852
Irritable bowel syndrome 21.24 10.22 475 485993 81937 62920617
Breast cancer 21.22 10.22 503 485965 47880 62954674
Nausea 21.02 10.22 7075 479393 847396 62155158
Chronic disease 21.01 10.22 14 486454 150 63002404
Hypoxia 20.89 10.22 327 486141 59465 62943089
Renal disorder 20.85 10.22 362 486106 32612 62969942
Pulmonary toxicity 20.85 10.22 25 486443 9430 62993124
Blood iron decreased 20.84 10.22 188 486280 14533 62988021
Stillbirth 20.77 10.22 13 486455 6737 62995817
Dental implantation 20.75 10.22 27 486441 715 63001839
Osteoporosis 20.74 10.22 581 485887 56757 62945797
Eye swelling 20.70 10.22 277 486191 23641 62978913
Intentional underdose 20.63 10.22 45 486423 1837 63000717
Hallucination, visual 20.63 10.22 77 486391 19221 62983333
Calciphylaxis 20.63 10.22 61 486407 3011 62999543
Bladder hypertrophy 20.45 10.22 16 486452 224 63002330
Dermatitis bullous 20.40 10.22 21 486447 8487 62994067
Groin pain 20.34 10.22 141 486327 10062 62992492
Myopathy 20.30 10.22 34 486434 11157 62991397
Subarachnoid haemorrhage 20.28 10.22 50 486418 14233 62988321
Infusion site extravasation 20.15 10.22 143 486325 10283 62992271
Palpitations 20.13 10.22 1057 485411 111713 62890841
Tooth fracture 20.11 10.22 150 486318 10960 62991594
Arthropod bite 20.09 10.22 117 486351 7861 62994693
Angina unstable 20.05 10.22 15 486453 7080 62995474
Blood magnesium decreased 19.96 10.22 171 486297 13027 62989527
Cyst 19.93 10.22 180 486288 13919 62988635
Acute myocardial infarction 19.93 10.22 154 486314 31970 62970584
Pancreatitis acute 19.93 10.22 124 486344 27042 62975512
Myocardial ischaemia 19.88 10.22 43 486425 12816 62989738
Blood cholesterol abnormal 19.84 10.22 55 486413 2616 62999938
Colitis microscopic 19.78 10.22 131 486337 9208 62993346
Isosthenuria 19.75 10.22 12 486456 108 63002446
Endometriosis 19.72 10.22 87 486381 5233 62997321
Fracture displacement 19.71 10.22 35 486433 1226 63001328
Urine odour abnormal 19.68 10.22 99 486369 6290 62996264
Restless legs syndrome 19.66 10.22 223 486245 18308 62984246
Post transplant lymphoproliferative disorder 19.61 10.22 7 486461 5024 62997530
Nephritic syndrome 19.58 10.22 18 486450 318 63002236
Depressed mood 19.56 10.22 424 486044 39767 62962787
Prescribed underdose 19.52 10.22 328 486140 29361 62973193
Graft versus host disease 19.50 10.22 14 486454 6749 62995805
Infusion site swelling 19.47 10.22 135 486333 9635 62992919
Sinus headache 19.44 10.22 90 486378 5526 62997028
Decreased interest 19.41 10.22 62 486406 3192 62999362
Sputum purulent 19.40 10.22 32 486436 1055 63001499
Intraductal proliferative breast lesion 19.32 10.22 58 486410 2887 62999667
Enterocolitis 19.30 10.22 19 486449 7839 62994715
Enterococcal infection 19.25 10.22 19 486449 7829 62994725
Epstein-Barr virus infection 19.16 10.22 20 486448 8030 62994524
Oliguria 19.09 10.22 25 486443 9076 62993478
Intervertebral disc protrusion 19.06 10.22 271 486197 23438 62979116
Encephalitis 19.03 10.22 24 486444 8856 62993698
Spinal compression fracture 19.01 10.22 180 486288 14103 62988451
Musculoskeletal chest pain 19.01 10.22 246 486222 20837 62981717
Blood cholesterol increased 18.99 10.22 892 485576 93140 62909414
Concomitant disease progression 18.98 10.22 47 486421 2087 63000467
Pulmonary oedema 18.53 10.22 302 486166 54571 62947983
Purpura 18.50 10.22 37 486431 11348 62991206
Red blood cell sedimentation rate 18.50 10.22 7 486461 4847 62997707
Polyneuropathy 18.50 10.22 54 486414 14535 62988019
Vitamin D abnormal 18.42 10.22 13 486455 154 63002400
Electrolyte imbalance 18.41 10.22 85 486383 19991 62982563
Arthritis 18.24 10.22 1074 485394 114847 62887707
Blood pressure systolic abnormal 18.12 10.22 48 486420 13338 62989216
Cholecystectomy 18.12 10.22 142 486326 10535 62992019
Pulmonary tuberculosis 18.10 10.22 6 486462 4511 62998043
Product monitoring error 18.09 10.22 6 486462 4510 62998044
Weight fluctuation 18.01 10.22 133 486335 9686 62992868
Hypernatraemia 18.00 10.22 19 486449 7590 62994964
Vasculitis 17.97 10.22 75 486393 18134 62984420
Hypocalcaemia 17.89 10.22 342 486126 31371 62971183
Abdominal discomfort 17.87 10.22 2169 484299 318716 62683838
Catatonia 17.84 10.22 6 486462 4471 62998083
Urine analysis abnormal 17.82 10.22 81 486387 4935 62997619
Tuberculosis 17.74 10.22 37 486431 11174 62991380
Hypothyroidism 17.73 10.22 440 486028 42192 62960362
Foetal growth restriction 17.71 10.22 19 486449 7534 62995020
Sciatica 17.64 10.22 365 486103 33959 62968595
Sinus bradycardia 17.63 10.22 55 486413 14496 62988058
Ileus 17.60 10.22 56 486412 14669 62987885
Galactorrhoea 17.58 10.22 5 486463 4150 62998404
Insurance issue 17.57 10.22 93 486375 6028 62996526
Paradoxical drug reaction 17.56 10.22 5 486463 4147 62998407
Dermatitis exfoliative 17.52 10.22 10 486458 5449 62997105
Dysstasia 17.45 10.22 243 486225 20923 62981631
Leukoencephalopathy 17.44 10.22 6 486462 4407 62998147
Hypothermia 17.42 10.22 50 486418 13531 62989023
Product prescribing error 17.28 10.22 124 486344 26165 62976389
Cardiac failure congestive 17.22 10.22 558 485910 91875 62910679
Ketoacidosis 17.22 10.22 6 486462 4372 62998182
Polymyalgia rheumatica 17.22 10.22 66 486402 3725 62998829
Cytomegalovirus viraemia 17.22 10.22 11 486457 5638 62996916
Hepatitis acute 17.21 10.22 27 486441 9093 62993461
Blood creatinine abnormal 17.13 10.22 57 486411 2999 62999555
Blood calcium abnormal 17.07 10.22 33 486435 1235 63001319
Malabsorption 16.97 10.22 69 486399 4003 62998551
Adverse drug reaction 16.92 10.22 760 485708 78954 62923600
Metabolic disorder 16.82 10.22 15 486453 6488 62996066
Onychoclasis 16.82 10.22 93 486375 6129 62996425
Eye pain 16.75 10.22 358 486110 33496 62969058
Pelvic fracture 16.68 10.22 166 486302 13182 62989372
Blood parathyroid hormone abnormal 16.67 10.22 14 486454 218 63002336
Abnormal behaviour 16.67 10.22 96 486372 21330 62981224
Pain in jaw 16.65 10.22 444 486024 43052 62959502
Injection site swelling 16.64 10.22 480 485988 47092 62955462
Increased tendency to bruise 16.64 10.22 138 486330 10414 62992140
Intentional product misuse 16.60 10.22 348 486120 60569 62941985
Open reduction of fracture 16.58 10.22 31 486437 1131 63001423
Hereditary angioedema 16.58 10.22 107 486361 7455 62995099
Drug withdrawal syndrome 16.58 10.22 131 486337 27063 62975491
Product complaint 16.54 10.22 47 486421 12762 62989792
Proctitis 16.54 10.22 84 486384 5357 62997197
Vestibular migraine 16.51 10.22 14 486454 221 63002333
Unevaluable event 16.49 10.22 513 485955 50873 62951681
Angina pectoris 16.49 10.22 149 486319 29929 62972625
Paroxysmal extreme pain disorder 16.46 10.22 10 486458 90 63002464
Product use issue 16.42 10.22 1460 485008 219060 62783494
Diabetic ketoacidosis 16.42 10.22 91 486377 20414 62982140
Hyperplastic cholecystopathy 16.40 10.22 12 486456 151 63002403
Cytomegalovirus infection reactivation 16.35 10.22 5 486463 3958 62998596
Ageusia 16.32 10.22 169 486299 13559 62988995
Peripheral venous disease 16.31 10.22 186 486282 15291 62987263
Erysipelas 16.29 10.22 22 486446 7883 62994671
Lower respiratory tract infection viral 16.29 10.22 27 486441 894 63001660
Tibia fracture 16.24 10.22 80 486388 5040 62997514
Lymphocyte percentage decreased 16.13 10.22 55 486413 2930 62999624
Peripheral sensory neuropathy 16.11 10.22 20 486448 7431 62995123
Hepatic necrosis 16.10 10.22 12 486456 5675 62996879
Collagen-vascular disease 16.09 10.22 10 486458 94 63002460
Oligohydramnios 16.09 10.22 15 486453 6351 62996203
Ear infection 16.07 10.22 395 486073 37818 62964736
Toxic encephalopathy 16.05 10.22 16 486452 6563 62995991
Pregnancy with contraceptive device 15.94 10.22 8 486460 4686 62997868
Hallucination, auditory 15.88 10.22 48 486420 12776 62989778
Lacrimation increased 15.87 10.22 234 486234 20397 62982157
Blood potassium decreased 15.80 10.22 428 486040 41598 62960956
Confusional arousal 15.77 10.22 13 486455 197 63002357
Tumour lysis syndrome 15.68 10.22 28 486440 8962 62993592
Skin sensitisation 15.64 10.22 26 486442 863 63001691
Carotid artery thrombosis 15.56 10.22 52 486416 2742 62999812
Patient elopement 15.55 10.22 7 486461 31 63002523
Exposure to toxic agent 15.55 10.22 12 486456 5575 62996979
Haemolytic anaemia 15.53 10.22 34 486434 10091 62992463
Transplant dysfunction 15.53 10.22 9 486459 4863 62997691
Gastric volvulus 15.50 10.22 5 486463 6 63002548
Heart rate abnormal 15.48 10.22 77 486391 4870 62997684
Upper gastrointestinal haemorrhage 15.46 10.22 83 486385 18769 62983785
Cervix neoplasm 15.40 10.22 13 486455 204 63002350
Sudden death 15.29 10.22 36 486432 10413 62992141
Infusion site pain 15.28 10.22 197 486271 16672 62985882
Compression fracture 15.23 10.22 93 486375 6355 62996199
Post procedural stroke 15.19 10.22 8 486460 53 63002501
Viral infection 15.11 10.22 369 486099 35294 62967260
Skin atrophy 15.09 10.22 76 486392 4830 62997724
Eye disorder 15.05 10.22 251 486217 22434 62980120
Hepatitis fulminant 14.97 10.22 4 486464 3460 62999094
Bradyphrenia 14.82 10.22 19 486449 6961 62995593
Metastases to liver 14.82 10.22 113 486355 23526 62979028
Red blood cell count increased 14.81 10.22 55 486413 3057 62999497
Type IIa hyperlipidaemia 14.74 10.22 11 486457 143 63002411
Blood magnesium increased 14.72 10.22 54 486414 2984 62999570
Endodontic procedure 14.70 10.22 56 486412 3151 62999403
Anal incontinence 14.69 10.22 164 486304 13412 62989142
Vaginal flatulence 14.69 10.22 57 486411 3236 62999318
Brain death 14.62 10.22 4 486464 3406 62999148
Neurologic neglect syndrome 14.59 10.22 50 486418 2671 62999883
Genital haemorrhage 14.52 10.22 21 486447 7311 62995243
Pulseless electrical activity 14.44 10.22 22 486446 7499 62995055
Low turnover osteopathy 14.44 10.22 67 486401 4118 62998436
Upper respiratory tract infection 14.43 10.22 768 485700 81279 62921275
Rhonchi 14.39 10.22 48 486420 2528 63000026
Activated partial thromboplastin time prolonged 14.39 10.22 19 486449 6874 62995680
Acute graft versus host disease 14.37 10.22 8 486460 4420 62998134
Colorectal cancer 14.33 10.22 5 486463 3640 62998914
Hysterectomy 14.32 10.22 123 486345 9376 62993178
Gallbladder operation 14.31 10.22 45 486423 2298 63000256
Torus fracture 14.30 10.22 11 486457 150 63002404
Tachypnoea 14.29 10.22 76 486392 17226 62985328
Unresponsive to stimuli 14.28 10.22 178 486290 33638 62968916
Electrocardiogram PR shortened 14.28 10.22 14 486454 269 63002285
Muscle rigidity 14.27 10.22 43 486425 11457 62991097
Hyperpyrexia 14.25 10.22 5 486463 3627 62998927
Drug screen positive 14.23 10.22 5 486463 3624 62998930
Colonoscopy 14.18 10.22 35 486433 1551 63001003
Product use in unapproved indication 14.17 10.22 1180 485288 177900 62824654
Myelodysplastic syndrome 14.17 10.22 73 486395 16681 62985873
Clonus 14.17 10.22 9 486459 4627 62997927
Increased appetite 14.16 10.22 124 486344 9506 62993048
Dysphonia 14.15 10.22 471 485997 47143 62955411
Bladder operation 14.11 10.22 26 486442 938 63001616
Bladder disorder 14.10 10.22 117 486351 8829 62993725
Psychomotor retardation 14.07 10.22 6 486462 3864 62998690
Faeces soft 14.02 10.22 83 486385 5609 62996945
Muscle strain 14.02 10.22 110 486358 8164 62994390
Ingrowing nail 14.01 10.22 46 486422 2403 63000151
Infusion site erythema 13.99 10.22 144 486324 11535 62991019
Breath sounds abnormal 13.97 10.22 137 486331 10836 62991718
Venoocclusive liver disease 13.95 10.22 10 486458 4825 62997729
Injection site rash 13.94 10.22 212 486256 18597 62983957
Cataract operation 13.91 10.22 81 486387 5441 62997113
Arrhythmia 13.86 10.22 207 486261 37933 62964621
Cutaneous vasculitis 13.81 10.22 12 486456 5257 62997297
Rheumatoid nodule 13.81 10.22 76 486392 17079 62985475
Substance abuse 13.80 10.22 10 486458 4797 62997757
Facet joint syndrome 13.76 10.22 148 486320 11990 62990564
Acne 13.76 10.22 253 486215 23040 62979514
Fungal infection 13.71 10.22 375 486093 36499 62966055
Nephrogenic systemic fibrosis 13.71 10.22 9 486459 4547 62998007
Ileus paralytic 13.68 10.22 9 486459 4542 62998012
Allergic sinusitis 13.66 10.22 28 486440 1094 63001460
Alopecia 13.63 10.22 2326 484142 335210 62667344
Product administration interrupted 13.56 10.22 73 486395 4763 62997791
Joint swelling 13.55 10.22 2255 484213 325411 62677143
Tenosynovitis 13.50 10.22 57 486411 13738 62988816
Full blood count increased 13.49 10.22 27 486441 1037 63001517
Dyslipidaemia 13.48 10.22 100 486368 7293 62995261
Dysarthria 13.47 10.22 238 486230 42473 62960081
Limb injury 13.45 10.22 272 486196 25205 62977349
Aspergillus infection 13.41 10.22 26 486442 8067 62994487
Cardiovascular disorder 13.38 10.22 46 486422 11766 62990788
Procedural pain 13.35 10.22 236 486232 21333 62981221
Anti-transglutaminase antibody increased 13.30 10.22 4 486464 3 63002551
Tooth infection 13.29 10.22 202 486266 17718 62984836
Skin toxicity 13.28 10.22 10 486458 4704 62997850
Exposure via ingestion 13.27 10.22 3 486465 2906 62999648
Myocarditis 13.25 10.22 38 486430 10287 62992267
Acidosis 13.23 10.22 43 486425 11190 62991364
Mucous stools 13.21 10.22 66 486402 4182 62998372
Invasive ductal breast carcinoma 13.20 10.22 95 486373 6863 62995691
Blood 25-hydroxycholecalciferol decreased 13.16 10.22 8 486460 72 63002482
Pyelitis 13.15 10.22 12 486456 210 63002344
SARS-CoV-2 test positive 13.05 10.22 106 486362 7950 62994604
Head banging 13.00 10.22 16 486452 400 63002154
Disseminated tuberculosis 13.00 10.22 3 486465 2864 62999690
Hyperlactacidaemia 12.88 10.22 3 486465 2846 62999708
Haematuria 12.88 10.22 152 486316 29005 62973549
Pancreatitis 12.85 10.22 282 486186 48773 62953781
Right ventricular failure 12.85 10.22 78 486390 17110 62985444
Body temperature decreased 12.82 10.22 223 486245 20096 62982458
Hypersomnia 12.81 10.22 202 486266 17853 62984701
Hypercalciuria 12.77 10.22 14 486454 308 63002246
Hyperprolactinaemia 12.72 10.22 7 486461 3893 62998661
Gingival recession 12.72 10.22 32 486436 1435 63001119
Chronic respiratory disease 12.70 10.22 11 486457 179 63002375
Bone marrow oedema 12.68 10.22 29 486439 1223 63001331
Neonatal respiratory distress syndrome 12.67 10.22 3 486465 2815 62999739
Low birth weight baby 12.62 10.22 22 486446 7107 62995447
Pneumonitis 12.51 10.22 192 486276 35030 62967524
Gastroenteritis viral 12.50 10.22 253 486215 23447 62979107
Gingival disorder 12.44 10.22 57 486411 3485 62999069
Breast cancer stage I 12.43 10.22 21 486447 6868 62995686
Nail bed disorder 12.41 10.22 13 486455 271 63002283
Radius fracture 12.40 10.22 58 486410 3577 62998977
Rash 12.37 10.22 3977 482491 556894 62445660
Rotator cuff syndrome 12.36 10.22 158 486310 13344 62989210
Faecal calprotectin increased 12.35 10.22 53 486415 3150 62999404
Hepatomegaly 12.34 10.22 48 486420 11841 62990713
Presbyacusis 12.30 10.22 49 486419 2816 62999738
Pain 12.28 10.22 6050 480418 734578 62267976
Bronchial wall thickening 12.27 10.22 32 486436 1467 63001087
Feeling cold 12.27 10.22 254 486214 23634 62978920
Eyelid margin crusting 12.17 10.22 26 486442 1046 63001508
Sensory loss 12.16 10.22 126 486342 10112 62992442
Enzyme level decreased 12.12 10.22 5 486463 17 63002537
Feeding disorder 12.08 10.22 156 486312 13206 62989348
Cervical vertebral fracture 12.08 10.22 46 486422 2588 62999966
Monocyte percentage increased 12.08 10.22 27 486441 1121 63001433
Oesophageal discomfort 12.07 10.22 11 486457 192 63002362
Stomatitis 12.07 10.22 907 485561 137818 62864736
Tongue discomfort 12.07 10.22 42 486426 2261 63000293
Tonsillectomy 12.06 10.22 23 486445 852 63001702
Blood pressure systolic decreased 12.06 10.22 24 486444 7373 62995181
Pancreatic enlargement 12.00 10.22 7 486461 58 63002496
Pulmonary haemorrhage 11.96 10.22 23 486445 7158 62995396
Carbohydrate antigen 15-3 increased 11.95 10.22 31 486437 1417 63001137
Azotaemia 11.95 10.22 10 486458 4461 62998093
Needle fatigue 11.93 10.22 9 486459 119 63002435
Injection site joint pain 11.90 10.22 4 486464 6 63002548
Hepatitis toxic 11.89 10.22 5 486463 3248 62999306
Carcinoembryonic antigen increased 11.81 10.22 35 486433 1730 63000824
Pulmonary alveolar haemorrhage 11.80 10.22 11 486457 4657 62997897
Disability assessment scale score increased 11.77 10.22 5 486463 3228 62999326
Atypical fracture 11.73 10.22 19 486449 617 63001937
Bone cyst 11.72 10.22 41 486427 2213 63000341
Urine ketone body present 11.72 10.22 44 486424 2459 63000095
Spinal pain 11.72 10.22 153 486315 12986 62989568
Fibula fracture 11.70 10.22 56 486412 3486 62999068
Laryngeal oedema 11.70 10.22 16 486452 5702 62996852
Tricuspid valve incompetence 11.65 10.22 65 486403 14556 62987998
Radical mastectomy 11.64 10.22 3 486465 0 63002554
Sinuplasty 11.64 10.22 3 486465 0 63002554
Rotavirus test positive 11.64 10.22 3 486465 0 63002554
Incarcerated inguinal hernia 11.64 10.22 3 486465 0 63002554
Refusal of treatment by patient 11.63 10.22 15 486453 5482 62997072
Mass excision 11.63 10.22 14 486454 342 63002212
Gout 11.61 10.22 154 486314 13117 62989437
Immunoglobulins increased 11.60 10.22 16 486452 449 63002105
Paranoia 11.59 10.22 48 486420 11631 62990923
Pleural fibrosis 11.55 10.22 55 486413 3417 62999137
Nocturia 11.54 10.22 104 486364 8037 62994517
Cardiomyopathy 11.53 10.22 83 486385 17501 62985053
Gastric ulcer 11.52 10.22 123 486345 23914 62978640
Lymphoproliferative disorder 11.51 10.22 5 486463 3185 62999369
Temperature intolerance 11.45 10.22 112 486356 8852 62993702
Retroperitoneal haematoma 11.44 10.22 4 486464 2909 62999645
Breast conserving surgery 11.41 10.22 25 486443 1024 63001530
Nephropathy toxic 11.37 10.22 36 486432 9443 62993111
Thyroxine decreased 11.36 10.22 19 486449 634 63001920
Neutralising antibodies positive 11.35 10.22 12 486456 253 63002301
Proteinuria 11.31 10.22 93 486375 19052 62983502
Jaw disorder 11.31 10.22 75 486393 5274 62997280
Vaginal discharge 11.30 10.22 114 486354 9084 62993470
Cholecystitis chronic 11.30 10.22 41 486427 10320 62992234
Neoplasm progression 11.25 10.22 362 486106 36066 62966488
Acute pulmonary oedema 11.24 10.22 29 486439 8129 62994425
Motor dysfunction 11.19 10.22 129 486339 10632 62991922
Vitamin A deficiency 11.18 10.22 4 486464 8 63002546
Drug use disorder 11.18 10.22 13 486455 4971 62997583
Infusion site haemorrhage 11.17 10.22 72 486396 5014 62997540
Duodenal ulcer 11.13 10.22 27 486441 7729 62994825
Feeling hot 11.11 10.22 482 485986 49872 62952682
Ankle deformity 11.10 10.22 16 486452 468 63002086
Hospice care 11.08 10.22 101 486367 7831 62994723
Lymph node pain 11.07 10.22 30 486438 1408 63001146
Heart rate irregular 11.06 10.22 237 486231 22184 62980370
Trichorrhexis 11.05 10.22 28 486440 1261 63001293
Adjustment disorder 11.05 10.22 51 486417 3127 62999427
Vaginal haematoma 11.05 10.22 9 486459 134 63002420
Bacterial vaginosis 11.02 10.22 30 486438 1412 63001142
Congestive cardiomyopathy 11.01 10.22 19 486449 6163 62996391
Impaired healing 11.01 10.22 658 485810 101884 62900670
Amyloid related imaging abnormality-oedema/effusion 11.00 10.22 10 486458 174 63002380
Physiotherapy 10.99 10.22 7 486461 69 63002485
Central obesity 10.97 10.22 27 486441 1194 63001360
Nasal oedema 10.97 10.22 31 486437 1491 63001063
Renal tubular dysfunction 10.90 10.22 15 486453 420 63002134
Head injury 10.88 10.22 281 486187 27115 62975439
Skin ulcer 10.84 10.22 249 486219 42796 62959758
Adenovirus infection 10.82 10.22 7 486461 3564 62998990
Breast pain 10.79 10.22 109 486359 8689 62993865
Anorectal stenosis 10.79 10.22 5 486463 24 63002530
Congenital coronary artery malformation 10.78 10.22 9 486459 139 63002415
Blood thyroid stimulating hormone increased 10.77 10.22 93 486375 7101 62995453
Obstruction 10.74 10.22 50 486418 3077 62999477
Stoma site discomfort 10.72 10.22 8 486460 104 63002450
Thyroxine free increased 10.69 10.22 22 486446 862 63001692
Apnoea 10.68 10.22 29 486439 7993 62994561
Weight bearing difficulty 10.68 10.22 44 486424 2568 62999986
Tachyarrhythmia 10.65 10.22 11 486457 4439 62998115
Breast disorder 10.64 10.22 43 486425 2487 63000067
Respiratory tract malformation 10.59 10.22 10 486458 183 63002371
Rash macular 10.58 10.22 244 486224 23120 62979434
Pleural thickening 10.58 10.22 47 486421 2836 62999718
Rash pruritic 10.57 10.22 560 485908 59239 62943315
Decreased immune responsiveness 10.53 10.22 69 486399 4832 62997722
Brain injury 10.52 10.22 24 486444 7019 62995535
Lactose intolerance 10.51 10.22 48 486420 2930 62999624
Invasive lobular breast carcinoma 10.50 10.22 22 486446 873 63001681
Dairy intolerance 10.50 10.22 7 486461 75 63002479
Large intestine polyp 10.46 10.22 102 486366 8055 62994499
Gastrointestinal polyp 10.46 10.22 6 486462 48 63002506
Vein discolouration 10.44 10.22 11 486457 231 63002323
Gingival pain 10.44 10.22 102 486366 8060 62994494
Carbohydrate antigen 125 increased 10.40 10.22 46 486422 2770 62999784
Lung cyst 10.38 10.22 13 486455 331 63002223
Nasal ulcer 10.37 10.22 40 486428 2264 63000290
Mouth ulceration 10.34 10.22 184 486284 32800 62969754
Skin wrinkling 10.33 10.22 25 486443 1094 63001460
Large intestine perforation 10.32 10.22 32 486436 8450 62994104
Cheilosis 10.31 10.22 4 486464 11 63002543
Restlessness 10.31 10.22 161 486307 29292 62973262
Tremor 10.31 10.22 1161 485307 131078 62871476
Feeling jittery 10.30 10.22 152 486316 13251 62989303
Gastrointestinal inflammation 10.29 10.22 76 486392 5536 62997018
Gastric bypass 10.28 10.22 34 486434 1783 63000771
Humerus fracture 10.24 10.22 109 486359 8807 62993747

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 447.28 10.32 187 162621 200175 34593948
Fatigue 413.11 10.32 3042 159766 367611 34426512
Drug interaction 337.76 10.32 333 162475 225613 34568510
Completed suicide 267.84 10.32 64 162744 98104 34696019
Product dose omission issue 264.18 10.32 1181 161627 118530 34675593
Drug abuse 261.87 10.32 69 162739 99027 34695096
Multiple sclerosis relapse 208.78 10.32 281 162527 12852 34781271
Acute kidney injury 199.34 10.32 740 162068 304248 34489875
Infective pulmonary exacerbation of cystic fibrosis 154.15 10.32 174 162634 6627 34787496
Intentional overdose 139.47 10.32 19 162789 43655 34750468
Overdose 137.13 10.32 133 162675 90926 34703197
Interstitial lung disease 122.83 10.32 76 162732 65206 34728917
Muscle spasms 117.98 10.32 673 162135 74328 34719795
Hepatic function abnormal 113.18 10.32 33 162775 44330 34749793
Coma 112.88 10.32 36 162772 45642 34748481
Cardiac failure 105.99 10.32 163 162645 91085 34703038
Sinusitis 103.87 10.32 425 162383 40977 34753146
Multiple organ dysfunction syndrome 99.68 10.32 126 162682 76440 34717683
Fall 99.53 10.32 1409 161399 201476 34592647
Thrombocytopenia 95.42 10.32 389 162419 155858 34638265
Suicide attempt 94.59 10.32 32 162776 39084 34755039
Peripheral swelling 93.02 10.32 643 162165 75898 34718225
Vitamin D deficiency 92.47 10.32 133 162675 6475 34787648
Plasma cell myeloma 91.96 10.32 414 162394 41623 34752500
Nasopharyngitis 88.12 10.32 593 162215 69375 34724748
Multiple sclerosis 87.56 10.32 130 162678 6515 34787608
Balance disorder 81.28 10.32 390 162418 40264 34753859
Weight decreased 79.94 10.32 1208 161600 175093 34619030
Febrile neutropenia 79.03 10.32 348 162460 136501 34657622
Cardio-respiratory arrest 78.33 10.32 85 162723 55188 34738935
Diarrhoea 77.45 10.32 2368 160440 387544 34406579
Rhabdomyolysis 77.01 10.32 124 162684 68039 34726084
Back pain 76.22 10.32 885 161923 120904 34673219
Memory impairment 74.96 10.32 399 162409 42919 34751204
Hyperkalaemia 72.20 10.32 133 162675 69256 34724867
Influenza 71.81 10.32 436 162372 49230 34744893
Constipation 68.14 10.32 954 161854 136028 34658095
Arthralgia 67.61 10.32 1140 161668 168901 34625222
Hypotension 67.15 10.32 684 162124 220965 34573158
Neutropenia 67.06 10.32 441 162367 156337 34637786
Drug reaction with eosinophilia and systemic symptoms 66.99 10.32 35 162773 32977 34761146
Depressed level of consciousness 66.30 10.32 61 162747 42780 34751343
Cardiac arrest 65.40 10.32 229 162579 95930 34698193
Full blood count abnormal 64.85 10.32 213 162595 18455 34775668
Inappropriate schedule of product administration 63.50 10.32 502 162306 61794 34732329
Cholestasis 61.84 10.32 24 162784 26924 34767199
Angioedema 61.74 10.32 50 162758 37324 34756799
Full blood count decreased 61.60 10.32 205 162603 17883 34776240
Serotonin syndrome 60.57 10.32 10 162798 19923 34774200
Septic shock 60.40 10.32 155 162653 71679 34722444
Relapsing-remitting multiple sclerosis 59.77 10.32 45 162763 1005 34793118
Toxic epidermal necrolysis 59.20 10.32 14 162794 21632 34772491
Altered state of consciousness 58.43 10.32 17 162791 22876 34771247
Muscle spasticity 58.12 10.32 101 162707 5787 34788336
Myelosuppression 57.80 10.32 10 162798 19255 34774868
Cough 57.63 10.32 1001 161807 149139 34644984
Drug resistance 56.41 10.32 25 162783 25902 34768221
Fractional exhaled nitric oxide increased 56.39 10.32 44 162764 1038 34793085
Hepatocellular injury 55.77 10.32 17 162791 22194 34771929
Agranulocytosis 55.01 10.32 21 162787 23800 34770323
Neuroleptic malignant syndrome 54.49 10.32 9 162799 17925 34776198
Pain in extremity 54.26 10.32 859 161949 125654 34668469
Rash maculo-papular 53.66 10.32 33 162775 28418 34765705
Feeling abnormal 53.07 10.32 488 162320 62747 34731376
Pain 52.94 10.32 1287 161521 203388 34590735
Electrocardiogram QT prolonged 52.64 10.32 68 162740 40884 34753239
Cytomegalovirus infection 52.60 10.32 28 162780 26107 34768016
Leukopenia 52.56 10.32 136 162672 62720 34731403
General physical health deterioration 52.24 10.32 366 162442 127903 34666220
Gait disturbance 52.02 10.32 616 162192 84524 34709599
Gait spastic 51.63 10.32 42 162766 1054 34793069
Hyponatraemia 51.59 10.32 204 162604 82487 34711636
Shock 51.53 10.32 24 162784 24155 34769968
Abdominal discomfort 50.84 10.32 463 162345 59372 34734751
Hypoaesthesia 48.97 10.32 469 162339 60975 34733148
Pancytopenia 47.90 10.32 254 162554 94903 34699220
Neuropathy peripheral 47.64 10.32 595 162213 82668 34711455
Colitis ulcerative 47.43 10.32 177 162631 16343 34777780
Respiratory failure 47.10 10.32 304 162504 108268 34685855
Asthenia 47.04 10.32 1484 161324 243767 34550356
Hepatic cytolysis 47.00 10.32 6 162802 14490 34779633
Hypoglycaemia 46.62 10.32 117 162691 54523 34739600
Lactic acidosis 46.51 10.32 56 162752 34716 34759407
Needle fatigue 46.29 10.32 36 162772 845 34793278
Pulmonary function test decreased 46.09 10.32 83 162725 4892 34789231
Metabolic acidosis 46.07 10.32 83 162725 43597 34750526
Disseminated intravascular coagulation 45.96 10.32 22 162786 21794 34772329
Hip fracture 45.93 10.32 141 162667 11784 34782339
Adverse drug reaction 45.23 10.32 262 162546 29080 34765043
Hot flush 44.93 10.32 185 162623 17881 34776242
Circulatory collapse 44.66 10.32 21 162787 21017 34773106
Prostatic specific antigen increased 44.43 10.32 160 162648 14520 34779603
Blood creatine phosphokinase increased 43.17 10.32 90 162718 44767 34749356
Renal failure 42.80 10.32 395 162413 130162 34663961
Intentional dose omission 42.61 10.32 66 162742 3434 34790689
Plantar fasciitis 41.06 10.32 50 162758 2066 34792057
Insomnia 41.00 10.32 696 162112 103211 34690912
Central nervous system lesion 40.90 10.32 92 162716 6371 34787752
Upper respiratory tract infection 40.87 10.32 279 162529 32780 34761343
Rhinorrhoea 40.75 10.32 231 162577 25437 34768686
Pyrexia 40.69 10.32 1211 161597 331802 34462321
Sleep apnoea syndrome 40.64 10.32 195 162613 20126 34773997
Hospitalisation 40.35 10.32 424 162384 56478 34737645
Cerebral infarction 39.13 10.32 42 162766 27413 34766710
Heart rate decreased 38.71 10.32 267 162541 31478 34762645
Toxic skin eruption 38.69 10.32 4 162804 11381 34782742
Tachycardia 38.49 10.32 234 162574 84538 34709585
Melaena 38.42 10.32 66 162742 35314 34758809
Sleep disorder due to a general medical condition 38.41 10.32 79 162729 5142 34788981
Anaphylactic reaction 38.15 10.32 57 162751 32244 34761879
Weight increased 37.74 10.32 626 162182 92407 34701716
Thrombosis 37.69 10.32 380 162428 50078 34744045
Influenza like illness 37.67 10.32 239 162569 27395 34766728
Frequent bowel movements 37.54 10.32 138 162670 12649 34781474
Obstructive airways disorder 37.23 10.32 157 162651 15337 34778786
Bone marrow failure 37.16 10.32 49 162759 29204 34764919
Spinal fracture 37.03 10.32 97 162711 7401 34786722
Hepatitis 37.02 10.32 34 162774 23870 34770253
Cystic fibrosis 36.86 10.32 42 162766 1616 34792507
Spirometry abnormal 36.78 10.32 29 162779 695 34793428
Mucosal inflammation 36.74 10.32 78 162730 38544 34755579
Mycotic allergy 36.72 10.32 27 162781 581 34793542
Respiratory arrest 36.63 10.32 46 162762 27997 34766126
Vitamin D decreased 36.11 10.32 61 162747 3415 34790708
Hypervitaminosis D 36.08 10.32 9 162799 4 34794119
Bradycardia 35.93 10.32 205 162603 75213 34718910
Headache 35.83 10.32 1204 161604 199431 34594692
Osteoporosis 35.76 10.32 135 162673 12533 34781590
Seasonal allergy 35.71 10.32 89 162719 6586 34787537
Mite allergy 35.40 10.32 28 162780 674 34793449
Hepatotoxicity 35.16 10.32 29 162779 21456 34772667
Musculoskeletal stiffness 35.08 10.32 352 162456 46328 34747795
Renal impairment 34.97 10.32 277 162531 94236 34699887
Respiratory distress 34.79 10.32 71 162737 35594 34758529
Pollakiuria 34.55 10.32 182 162626 19492 34774631
Hypertonic bladder 34.49 10.32 43 162765 1821 34792302
Bowel movement irregularity 34.27 10.32 55 162753 2950 34791173
Body height decreased 34.19 10.32 63 162745 3780 34790343
Extrapyramidal disorder 33.92 10.32 9 162799 12871 34781252
Delirium 33.91 10.32 99 162709 43892 34750231
Intentional self-injury 33.75 10.32 11 162797 13760 34780363
Acute respiratory distress syndrome 33.50 10.32 43 162765 25926 34768197
Myocardial infarction 33.24 10.32 382 162426 120703 34673420
Sensation of foreign body 33.21 10.32 52 162756 2731 34791392
Labelled drug-drug interaction medication error 33.14 10.32 14 162794 14925 34779198
Pneumocystis jirovecii pneumonia 33.01 10.32 26 162782 19684 34774439
Psoriasis 32.79 10.32 300 162508 38512 34755611
Therapeutic product effect incomplete 32.78 10.32 370 162438 50171 34743952
Bronchial wall thickening 32.72 10.32 36 162772 1332 34792791
Mobility decreased 32.46 10.32 246 162562 29882 34764241
Bone giant cell tumour 32.21 10.32 10 162798 22 34794101
Wheezing 31.98 10.32 314 162494 41088 34753035
Stevens-Johnson syndrome 31.97 10.32 24 162784 18615 34775508
White blood cell count decreased 31.91 10.32 623 162185 94822 34699301
Conjunctivitis allergic 31.89 10.32 33 162775 1137 34792986
Intervertebral disc degeneration 31.67 10.32 83 162725 6334 34787789
Blood pressure fluctuation 31.16 10.32 213 162595 25036 34769087
Dust allergy 31.12 10.32 29 162779 877 34793246
Bronchial secretion retention 30.96 10.32 37 162771 1499 34792624
Miosis 30.79 10.32 4 162804 9531 34784592
Accidental overdose 30.77 10.32 29 162779 20111 34774012
Laboratory test abnormal 30.73 10.32 181 162627 20210 34773913
Nocturia 30.66 10.32 111 162697 10099 34784024
Foetal exposure during pregnancy 30.66 10.32 84 162724 38017 34756106
Vitamin D increased 30.33 10.32 12 162796 66 34794057
Productive cough 30.30 10.32 289 162519 37524 34756599
Red blood cell count decreased 29.94 10.32 235 162573 28855 34765268
Anuria 29.85 10.32 6 162802 10379 34783744
Anaemia 29.82 10.32 843 161965 232492 34561631
Jaundice 29.81 10.32 65 162743 31817 34762306
Cerebral haemorrhage 29.65 10.32 75 162733 34862 34759261
Nephrolithiasis 29.56 10.32 242 162566 30091 34764032
Dyspepsia 29.56 10.32 281 162527 36451 34757672
Cardiogenic shock 29.51 10.32 49 162759 26569 34767554
Epilepsy 29.41 10.32 34 162774 21461 34772662
Hepatic failure 29.41 10.32 74 162734 34457 34759666
Anaphylactic shock 29.36 10.32 19 162789 15922 34778201
Polydactyly 29.15 10.32 32 162776 1181 34792942
Blood bilirubin increased 28.93 10.32 87 162721 38209 34755914
Secretion discharge 28.76 10.32 76 162732 5829 34788294
Gamma-glutamyltransferase increased 28.67 10.32 58 162750 29173 34764950
Localised infection 28.39 10.32 159 162649 17428 34776695
Cataract 28.32 10.32 214 162594 25972 34768151
Blood 25-hydroxycholecalciferol increased 28.14 10.32 7 162801 3 34794120
Atrioventricular septal defect 28.08 10.32 16 162792 218 34793905
Agitation 27.88 10.32 155 162653 57244 34736879
Status epilepticus 27.70 10.32 12 162796 12602 34781521
Vomiting 27.63 10.32 911 161897 246710 34547413
Flatulence 27.46 10.32 181 162627 21017 34773106
Blood pressure increased 27.43 10.32 569 162239 87533 34706590
Neutropenic sepsis 27.34 10.32 15 162793 13752 34780371
Bone density decreased 27.24 10.32 39 162769 1890 34792233
Hyperbilirubinaemia 27.24 10.32 23 162785 16820 34777303
Upper limb fracture 27.04 10.32 65 162743 4701 34789422
Angina pectoris 26.87 10.32 67 162741 31296 34762827
Monoparesis 26.84 10.32 43 162765 2303 34791820
Nephrocalcinosis 26.73 10.32 23 162785 625 34793498
Blood lactate dehydrogenase increased 26.73 10.32 41 162767 22949 34771174
Hyperthermia 26.73 10.32 8 162800 10569 34783554
Haemodynamic instability 26.35 10.32 6 162802 9517 34784606
Dandy-Walker syndrome 26.35 10.32 15 162793 204 34793919
COVID-19 26.19 10.32 507 162301 77043 34717080
Liver function test abnormal 26.14 10.32 67 162741 31007 34763116
Hernia 26.13 10.32 101 162707 9482 34784641
Nephropathy toxic 26.05 10.32 13 162795 12575 34781548
Exposure during pregnancy 26.02 10.32 5 162803 8929 34785194
Ageusia 25.19 10.32 105 162703 10203 34783920
Acne 24.95 10.32 110 162698 10956 34783167
Sedation 24.87 10.32 37 162771 20969 34773154
Dizziness 24.86 10.32 1250 161558 217271 34576852
Hypersomnia 24.76 10.32 119 162689 12288 34781835
Drug ineffective 24.60 10.32 1814 160994 454937 34339186
Gastrointestinal disorder 24.55 10.32 254 162554 33694 34760429
Poor venous access 24.53 10.32 66 162742 5117 34789006
Acute hepatic failure 24.29 10.32 18 162790 14056 34780067
C-reactive protein increased 24.20 10.32 150 162658 53948 34740175
Upper-airway cough syndrome 24.04 10.32 52 162756 3506 34790617
Medication error 24.00 10.32 52 162756 25513 34768610
Ventricular fibrillation 23.86 10.32 44 162764 22910 34771213
Premature baby 23.81 10.32 34 162774 19599 34774524
Incorrect dose administered 23.79 10.32 291 162517 40224 34753899
Hypokalaemia 23.72 10.32 166 162642 58048 34736075
Asthma 23.60 10.32 303 162505 42353 34751770
Nasal congestion 23.58 10.32 186 162622 22871 34771252
International normalised ratio increased 23.43 10.32 127 162681 47200 34746923
Aspergillus infection 23.40 10.32 14 162794 12240 34781883
Hospice care 23.04 10.32 78 162730 6862 34787261
Therapy interrupted 22.89 10.32 125 162683 13572 34780551
Substance abuse 22.85 10.32 4 162804 7637 34786486
Biliary cirrhosis 22.69 10.32 11 162797 105 34794018
Myoglobin blood increased 22.54 10.32 46 162762 2977 34791146
Loss of personal independence in daily activities 22.47 10.32 245 162563 32934 34761189
Inappropriate antidiuretic hormone secretion 22.42 10.32 16 162792 12737 34781386
Haematemesis 22.36 10.32 61 162747 27650 34766473
Pulmonary haemorrhage 22.31 10.32 10 162798 10294 34783829
Micturition urgency 22.25 10.32 74 162734 6451 34787672
Nasal polyps 22.22 10.32 41 162767 2462 34791661
Abdominal distension 22.04 10.32 389 162419 58103 34736020
Hepatitis cholestatic 22.01 10.32 5 162803 7942 34786181
Blood parathyroid hormone increased 21.96 10.32 31 162777 1483 34792640
Haemophagocytic lymphohistiocytosis 21.87 10.32 17 162791 12956 34781167
Dyspnoea exertional 21.70 10.32 302 162506 42977 34751146
Weight fluctuation 21.57 10.32 63 162745 5122 34789001
Dysphonia 21.42 10.32 184 162624 23199 34770924
Clostridium difficile infection 21.32 10.32 156 162652 18742 34775381
Contusion 21.27 10.32 261 162547 36103 34758020
Myocardial ischaemia 21.26 10.32 30 162778 17378 34776745
Gastrooesophageal reflux disease 21.24 10.32 270 162538 37654 34756469
Renal tubular necrosis 21.24 10.32 25 162783 15655 34778468
Osteopenia 21.22 10.32 60 162748 4789 34789334
Hypercalcaemia 21.21 10.32 134 162674 15334 34778789
Joint swelling 21.05 10.32 394 162414 59496 34734627
Surgery 20.90 10.32 125 162683 14032 34780091
Gastrointestinal infection 20.89 10.32 67 162741 5731 34788392
Ascites 20.89 10.32 129 162679 46442 34747681
Oropharyngeal pain 20.89 10.32 255 162553 35230 34758893
Pathogen resistance 20.85 10.32 9 162799 9473 34784650
Squamous cell carcinoma of skin 20.74 10.32 103 162705 10778 34783345
Akathisia 20.73 10.32 6 162802 8103 34786020
Aggression 20.73 10.32 102 162706 38862 34755261
Epstein-Barr virus infection 20.73 10.32 5 162803 7623 34786500
Right atrial hypertrophy 20.68 10.32 22 162786 783 34793340
Alanine aminotransferase increased 20.62 10.32 259 162549 80556 34713567
Hepatitis acute 20.62 10.32 5 162803 7596 34786527
Rib fracture 20.53 10.32 126 162682 14274 34779849
Gait inability 20.43 10.32 166 162642 20592 34773531
Bronchopulmonary aspergillosis 20.26 10.32 23 162785 14636 34779487
Tumour lysis syndrome 20.24 10.32 30 162778 17029 34777094
Intentional product misuse 20.12 10.32 127 162681 45484 34748639
Renal disorder 20.04 10.32 194 162614 25286 34768837
Limb discomfort 19.95 10.32 103 162705 10944 34783179
Joint ankylosis 19.64 10.32 30 162778 1542 34792581
Acute myocardial infarction 19.60 10.32 158 162650 53561 34740562
Pleural effusion 19.46 10.32 265 162543 81281 34712842
Hypercalciuria 19.41 10.32 14 162794 292 34793831
Antineutrophil cytoplasmic antibody positive 19.39 10.32 21 162787 763 34793360
Myoclonus 19.39 10.32 24 162784 14701 34779422
Aspartate aminotransferase increased 19.31 10.32 212 162596 67571 34726552
Respiratory symptom 19.29 10.32 32 162776 1765 34792358
Exostosis 19.27 10.32 57 162751 4666 34789457
Pulmonary oedema 19.13 10.32 136 162672 47393 34746730
Drug level increased 19.09 10.32 47 162761 22049 34772074
Torsade de pointes 19.06 10.32 5 162803 7204 34786919
Paraesthesia 18.85 10.32 411 162397 63761 34730362
Urinary tract infection 18.83 10.32 519 162289 83562 34710561
Cyanosis 18.78 10.32 19 162789 12745 34781378
Sudden death 18.76 10.32 26 162782 15175 34778948
Cytokine release syndrome 18.73 10.32 50 162758 22827 34771296
Heart rate irregular 18.70 10.32 132 162676 15675 34778448
Muscular weakness 18.66 10.32 458 162350 72439 34721684
Movement disorder 18.63 10.32 109 162699 12139 34781984
Chest discomfort 18.57 10.32 357 162451 54173 34739950
Neck pain 18.48 10.32 190 162618 25159 34768964
Illness 18.43 10.32 117 162691 13412 34780711
Ventricular tachycardia 18.25 10.32 63 162745 26516 34767607
Hypertensive crisis 18.17 10.32 9 162799 8742 34785381
Mucormycosis 18.01 10.32 3 162805 5939 34788184
Condition aggravated 18.00 10.32 1080 161728 191116 34603007
Viral infection 17.93 10.32 142 162666 17481 34776642
Erythema multiforme 17.80 10.32 9 162799 8640 34785483
Shock haemorrhagic 17.76 10.32 16 162792 11338 34782785
Febrile bone marrow aplasia 17.72 10.32 8 162800 8201 34785922
Sepsis 17.56 10.32 617 162191 165944 34628179
Neurotoxicity 17.44 10.32 36 162772 17974 34776149
Musculoskeletal disorder 17.42 10.32 66 162742 6138 34787985
Hyperglycaemia 17.38 10.32 110 162698 39370 34754753
Arthritis 17.06 10.32 222 162586 31124 34762999
Neurodevelopmental disorder 17.00 10.32 15 162793 422 34793701
Therapy partial responder 16.99 10.32 12 162796 9604 34784519
Product use in unapproved indication 16.95 10.32 417 162391 117082 34677041
Intentional product use issue 16.90 10.32 381 162427 59435 34734688
Blood calcium decreased 16.83 10.32 92 162716 9992 34784131
Venoocclusive liver disease 16.83 10.32 8 162800 7958 34786165
Trisomy 21 16.80 10.32 17 162791 570 34793553
Dry skin 16.78 10.32 221 162587 31066 34763057
Nerve degeneration 16.70 10.32 11 162797 197 34793926
Skin injury 16.69 10.32 35 162773 2310 34791813
Tooth disorder 16.66 10.32 97 162711 10785 34783338
Thrombotic microangiopathy 16.60 10.32 15 162793 10615 34783508
Heparin-induced thrombocytopenia 16.58 10.32 3 162805 5592 34788531
Tooth infection 16.57 10.32 69 162739 6702 34787421
Pleural thickening 16.57 10.32 14 162794 371 34793752
Suicidal ideation 16.53 10.32 115 162693 40273 34753850
Tubulointerstitial nephritis 16.43 10.32 47 162761 20977 34773146
Congenital supraventricular tachycardia 16.42 10.32 5 162803 10 34794113
Obstruction 16.42 10.32 38 162770 2681 34791442
Malignant neoplasm progression 16.34 10.32 300 162508 87746 34706377
Nonspecific reaction 16.33 10.32 26 162782 1385 34792738
Dysstasia 16.32 10.32 105 162703 12090 34782033
Blood testosterone decreased 16.30 10.32 51 162757 4306 34789817
Hypocalcaemia 16.28 10.32 179 162629 24110 34770013
Pre-eclampsia 16.17 10.32 7 162801 50 34794073
Psychotic disorder 16.09 10.32 59 162749 24393 34769730
Cardiac disorder 15.95 10.32 286 162522 42840 34751283
Gastrointestinal haemorrhage 15.95 10.32 303 162505 88174 34705949
Hordeolum 15.78 10.32 22 162786 1040 34793083
Eosinophil percentage increased 15.73 10.32 16 162792 540 34793583
Product use issue 15.53 10.32 395 162413 62821 34731302
Rash 15.46 10.32 1221 161587 221531 34572592
Joint lock 15.46 10.32 24 162784 1251 34792872
Carcinoid tumour 15.35 10.32 11 162797 227 34793896
Hyperexplexia 15.32 10.32 6 162802 32 34794091
Ankylosing spondylitis 15.22 10.32 59 162749 5545 34788578
Bone cyst 15.21 10.32 27 162781 1573 34792550
Product administration interrupted 15.20 10.32 29 162779 1786 34792337
Cellulitis 15.19 10.32 338 162470 52613 34741510
Mantle cell lymphoma stage IV 15.09 10.32 7 162801 60 34794063
Dermatitis exfoliative 15.08 10.32 6 162802 6633 34787490
Macrocephaly 15.07 10.32 15 162793 493 34793630
Dysgeusia 14.98 10.32 189 162619 26308 34767815
Multiple allergies 14.98 10.32 39 162769 2964 34791159
Acute graft versus host disease in skin 14.96 10.32 3 162805 5198 34788925
Back disorder 14.91 10.32 66 162742 6585 34787538
Bone marrow oedema 14.90 10.32 17 162791 655 34793468
Prostate cancer metastatic 14.88 10.32 60 162748 5743 34788380
Cardiovascular somatic symptom disorder 14.88 10.32 6 162802 35 34794088
Gastroenteritis viral 14.70 10.32 69 162739 7055 34787068
Arrhythmia 14.64 10.32 102 162706 35706 34758417
Cytomegalovirus infection reactivation 14.62 10.32 3 162805 5115 34789008
Essential hypertension 14.61 10.32 39 162769 3009 34791114
Hypertransaminasaemia 14.61 10.32 4 162804 5602 34788521
Lung hernia 14.61 10.32 7 162801 65 34794058
Respiratory tract congestion 14.58 10.32 62 162746 6077 34788046
Infusion site extravasation 14.58 10.32 49 162759 4295 34789828
Restlessness 14.56 10.32 65 162743 25417 34768706
Injection site pain 14.54 10.32 259 162549 38746 34755377
JC polyomavirus test positive 14.39 10.32 17 162791 680 34793443
Pre-existing condition improved 14.33 10.32 35 162773 2557 34791566
Hypertriglyceridaemia 14.33 10.32 11 162797 8437 34785686
Secondary progressive multiple sclerosis 14.32 10.32 13 162795 380 34793743
Hypoacusis 14.27 10.32 127 162681 16174 34777949
Psoriatic arthropathy 14.25 10.32 148 162660 19650 34774473
Therapeutic reaction time decreased 14.25 10.32 23 162785 1240 34792883
Subarachnoid haemorrhage 14.24 10.32 23 162785 12612 34781511
Asphyxia 14.23 10.32 7 162801 6828 34787295
Furuncle 14.16 10.32 41 162767 3317 34790806
Urine leukocyte esterase positive 14.14 10.32 14 162794 457 34793666
Bone pain 14.12 10.32 153 162655 20533 34773590
Vitamin B12 decreased 14.11 10.32 23 162785 1250 34792873
Brain natriuretic peptide increased 14.11 10.32 58 162750 5601 34788522
Haemodialysis 14.02 10.32 17 162791 10509 34783614
Blood test abnormal 14.01 10.32 67 162741 6904 34787219
Skin cancer 13.99 10.32 89 162719 10208 34783915
Brain oedema 13.92 10.32 27 162781 13794 34780329
Flushing 13.82 10.32 220 162588 32200 34761923
Plasma cell myeloma recurrent 13.80 10.32 49 162759 4416 34789707
Ataxia 13.75 10.32 111 162697 13742 34780381
Stomatitis 13.75 10.32 129 162679 42385 34751738
Temperature intolerance 13.68 10.32 41 162767 3381 34790742
Compression fracture 13.58 10.32 38 162770 3014 34791109
Prostatomegaly 13.52 10.32 55 162753 5286 34788837
Oesophageal carcinoma 13.52 10.32 14 162794 9290 34784833
Blood potassium decreased 13.41 10.32 135 162673 17780 34776343
Hand deformity 13.38 10.32 43 162765 3682 34790441
Aortic valve stenosis 13.38 10.32 35 162773 2668 34791455
Atrial septal defect 13.36 10.32 9 162799 7383 34786740
Posterior reversible encephalopathy syndrome 13.34 10.32 16 162792 9938 34784185
Rubber sensitivity 13.33 10.32 10 162798 222 34793901
Growth hormone deficiency 13.29 10.32 11 162797 283 34793840
C-reactive protein decreased 13.23 10.32 29 162779 1973 34792150
Gastric haemorrhage 13.22 10.32 17 162791 10244 34783879
Cardiomegaly 13.21 10.32 33 162775 15405 34778718
Bone cancer 13.21 10.32 25 162783 1531 34792592
Rash pruritic 13.10 10.32 187 162621 26754 34767369
Unevaluable event 13.09 10.32 219 162589 32371 34761752
Unresponsive to stimuli 13.08 10.32 75 162733 27494 34766629
Gastric disorder 13.07 10.32 101 162707 12340 34781783
Ear infection 13.03 10.32 87 162721 10144 34783979
Sickle cell anaemia with crisis 12.97 10.32 45 162763 4008 34790115
Drug withdrawal syndrome 12.96 10.32 48 162760 19786 34774337
Inability to afford medication 12.95 10.32 24 162784 1446 34792677
Colitis ischaemic 12.94 10.32 7 162801 6468 34787655
Sphincter of Oddi dysfunction 12.92 10.32 8 162800 128 34793995
Milk-alkali syndrome 12.90 10.32 15 162793 590 34793533
Osteolysis 12.85 10.32 38 162770 3110 34791013
Cystic fibrosis respiratory infection suppression 12.85 10.32 10 162798 235 34793888
Fear 12.85 10.32 18 162790 10458 34783665
Seborrhoeic keratosis 12.80 10.32 22 162786 1249 34792874
Ileus paralytic 12.70 10.32 6 162802 5991 34788132
Benign abdominal neoplasm 12.70 10.32 7 162801 89 34794034
Glossodynia 12.70 10.32 42 162766 3651 34790472
Skeletal injury 12.68 10.32 13 162795 443 34793680
Depression 12.62 10.32 563 162245 96535 34697588
Pancreatitis acute 12.59 10.32 78 162730 28063 34766060
Lacrimation increased 12.59 10.32 75 162733 8407 34785716
Congenital central nervous system anomaly 12.56 10.32 15 162793 607 34793516
Hyperammonaemia 12.55 10.32 7 162801 6360 34787763
Osteonecrosis of jaw 12.53 10.32 133 162675 17756 34776367
Anti-cyclic citrullinated peptide antibody positive 12.53 10.32 27 162781 1816 34792307
Congestive cardiomyopathy 12.46 10.32 10 162798 7500 34786623
Pneumonia aspiration 12.36 10.32 130 162678 41773 34752350
Bone lesion 12.32 10.32 36 162772 2927 34791196
Pallor 12.26 10.32 69 162739 25411 34768712
Vitamin D abnormal 12.26 10.32 4 162804 11 34794112
Right ventricular hypertrophy 12.23 10.32 24 162784 1510 34792613
Bone scan abnormal 12.22 10.32 6 162802 59 34794064
Congenital coronary artery malformation 12.22 10.32 6 162802 59 34794064
Specific gravity urine increased 12.16 10.32 8 162800 143 34793980
Blood iron decreased 12.12 10.32 53 162755 5260 34788863
Lung neoplasm malignant 12.10 10.32 41 162767 17354 34776769
Increased tendency to bruise 12.07 10.32 44 162764 4017 34790106
Dystonia 11.98 10.32 20 162788 10825 34783298
Chest expansion decreased 11.97 10.32 8 162800 147 34793976
Dermatitis atopic 11.94 10.32 53 162755 5294 34788829
Disorientation 11.92 10.32 98 162710 33090 34761033
Acute pulmonary oedema 11.91 10.32 10 162798 7333 34786790
Rheumatoid arthritis 11.90 10.32 247 162561 37991 34756132
Haemolytic anaemia 11.88 10.32 19 162789 10460 34783663
Therapeutic response unexpected 11.85 10.32 82 162726 9675 34784448
Drug eruption 11.83 10.32 50 162758 19848 34774275
Stress fracture 11.78 10.32 18 162790 925 34793198
Sneezing 11.73 10.32 52 162756 5190 34788933
Hypothermia 11.71 10.32 20 162788 10728 34783395
Faecal calprotectin increased 11.64 10.32 32 162776 2512 34791611
Acute graft versus host disease 11.64 10.32 8 162800 6495 34787628
Burning sensation 11.62 10.32 134 162674 18260 34775863
Arthropod bite 11.56 10.32 34 162774 2775 34791348
Mydriasis 11.56 10.32 10 162798 7227 34786896
Cystitis haemorrhagic 11.55 10.32 6 162802 5673 34788450
Bile acid malabsorption 11.55 10.32 4 162804 14 34794109
Intestinal stenosis 11.54 10.32 29 162779 2157 34791966
Attention deficit hyperactivity disorder 11.53 10.32 32 162776 2527 34791596
Ileal stenosis 11.49 10.32 22 162786 1359 34792764
Acute myeloid leukaemia 11.43 10.32 45 162763 18225 34775898
Polyp 11.42 10.32 42 162766 3850 34790273
Band sensation 11.31 10.32 7 162801 112 34794011
Full blood count increased 11.25 10.32 17 162791 865 34793258
Loss of consciousness 11.21 10.32 296 162512 82371 34711752
Renal neoplasm 11.21 10.32 21 162787 1276 34792847
Maternal exposure before pregnancy 11.18 10.32 16 162792 775 34793348
Infection 11.13 10.32 524 162284 90391 34703732
Ketoacidosis 11.11 10.32 3 162805 4240 34789883
Injection site erythema 11.04 10.32 118 162690 15781 34778342
Lactose intolerance 11.00 10.32 21 162787 1294 34792829
Therapeutic product effect decreased 11.00 10.32 225 162583 34518 34759605
Coagulopathy 10.99 10.32 51 162757 19738 34774385
Contraindicated product administered 10.98 10.32 57 162751 21424 34772699
Blood pressure abnormal 10.98 10.32 70 162738 8036 34786087
Cyst 10.97 10.32 46 162762 4482 34789641
Intestinal obstruction 10.93 10.32 158 162650 22664 34771459
Dental caries 10.91 10.32 46 162762 4493 34789630
Hepatitis fulminant 10.90 10.32 3 162805 4187 34789936
Transurethral prostatectomy 10.87 10.32 11 162797 369 34793754
Ejection fraction decreased 10.85 10.32 49 162759 19105 34775018
Accident at work 10.83 10.32 16 162792 798 34793325
Skin discolouration 10.83 10.32 129 162679 17716 34776407
Lower limb fracture 10.82 10.32 43 162765 4088 34790035
Nail infection 10.77 10.32 10 162798 301 34793822
Sinus disorder 10.74 10.32 63 162745 7022 34787101
Polyneuropathy in malignant disease 10.73 10.32 9 162799 236 34793887
Limb injury 10.72 10.32 92 162716 11597 34782526
Refusal of treatment by patient 10.71 10.32 5 162803 5027 34789096
Insurance issue 10.71 10.32 27 162781 2012 34792111
No adverse event 10.70 10.32 158 162650 22769 34771354
Cystitis 10.66 10.32 80 162728 9685 34784438
Device issue 10.62 10.32 80 162728 9697 34784426
Philadelphia positive chronic myeloid leukaemia 10.59 10.32 7 162801 126 34793997
Spinal operation 10.59 10.32 34 162774 2910 34791213
Nodule 10.58 10.32 61 162747 6758 34787365
Concussion 10.54 10.32 30 162778 2403 34791720
Metastatic renal cell carcinoma 10.52 10.32 27 162781 2034 34792089
Neuritis 10.52 10.32 17 162791 917 34793206
Blood parathyroid hormone decreased 10.43 10.32 22 162786 1458 34792665
Tachypnoea 10.37 10.32 47 162761 18305 34775818
Heart rate increased 10.35 10.32 286 162522 46057 34748066
Disease progression 10.34 10.32 405 162403 107672 34686451

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 1452.05 9.73 415 496750 421125 78826098
Completed suicide 985.93 9.73 172 496993 245595 79001628
Drug interaction 797.20 9.73 848 496317 414335 78832888
Drug abuse 721.91 9.73 84 497081 162607 79084616
Acute kidney injury 614.41 9.73 1465 495700 517939 78729284
Fatigue 520.43 9.73 8402 488763 921325 78325898
Multiple sclerosis relapse 498.67 9.73 976 496189 45557 79201666
Product dose omission issue 469.42 9.73 2892 494273 244645 79002578
Intentional overdose 464.32 9.73 57 497108 105903 79141320
Overdose 425.36 9.73 316 496849 183890 79063333
Headache 309.10 9.73 5755 491410 648017 78599206
Thrombocytopenia 308.37 9.73 754 496411 264505 78982718
Hypotension 292.05 9.73 1583 495582 438734 78808489
Cardio-respiratory arrest 288.99 9.73 158 497007 108352 79138871
Muscle spasms 281.35 9.73 1960 495205 172770 79074453
Multiple organ dysfunction syndrome 280.46 9.73 204 496961 120042 79127181
Back pain 273.59 9.73 3000 494165 301180 78946043
Hepatic function abnormal 270.26 9.73 62 497103 73045 79174178
Cardiac arrest 264.17 9.73 415 496750 171681 79075542
Infective pulmonary exacerbation of cystic fibrosis 250.68 9.73 353 496812 12498 79234725
Depressed level of consciousness 237.32 9.73 155 497010 96497 79150726
Cardiac failure 233.29 9.73 378 496787 154464 79092759
Pain in extremity 229.14 9.73 3364 493801 361174 78886049
Febrile neutropenia 228.55 9.73 710 496455 230289 79016934
Hypoaesthesia 219.75 9.73 1888 495277 177464 79069759
Hyperkalaemia 212.04 9.73 240 496925 114158 79133065
Suicide attempt 211.89 9.73 127 497038 82805 79164418
Rhabdomyolysis 209.61 9.73 200 496965 102931 79144292
Drug reaction with eosinophilia and systemic symptoms 206.80 9.73 71 497094 64173 79183050
Hyponatraemia 202.30 9.73 511 496654 177337 79069886
Muscle spasticity 189.59 9.73 416 496749 21059 79226164
Electrocardiogram QT prolonged 188.74 9.73 171 496994 90215 79157008
Neutropenia 188.52 9.73 1038 496127 286672 78960551
Sopor 186.08 9.73 4 497161 33006 79214217
Septic shock 182.89 9.73 302 496863 122499 79124724
Arthralgia 178.75 9.73 4747 492418 567056 78680167
Pancytopenia 177.28 9.73 491 496674 165254 79081969
Lactic acidosis 171.14 9.73 114 497051 70245 79176978
Coma 168.83 9.73 228 496937 100421 79146802
Sinusitis 167.30 9.73 1910 495255 193591 79053632
Interstitial lung disease 165.74 9.73 279 496886 112321 79134902
Multiple sclerosis 164.14 9.73 402 496763 21880 79225343
Hepatocellular injury 163.18 9.73 47 497118 47546 79199677
Metabolic acidosis 161.99 9.73 165 497000 82364 79164859
Drug ineffective 158.20 9.73 5341 491824 1075572 78171651
Feeling abnormal 156.43 9.73 1599 495566 157600 79089623
Insomnia 154.05 9.73 2263 494902 242907 79004316
Respiratory failure 148.83 9.73 601 496564 180310 79066913
Memory impairment 146.78 9.73 1195 495970 110539 79136684
Bradycardia 144.63 9.73 402 496763 135155 79112068
Gait disturbance 143.86 9.73 1949 495216 205557 79041666
Fall 139.47 9.73 4003 493162 483626 78763597
Pain 139.47 9.73 5534 491631 698268 78548955
Agranulocytosis 139.43 9.73 53 497112 44977 79202246
Renal failure 139.40 9.73 711 496454 200257 79046966
Cytomegalovirus infection 139.21 9.73 46 497119 42598 79204625
Influenza like illness 138.28 9.73 842 496323 70865 79176358
Cholestasis 137.08 9.73 77 497088 52032 79195191
Peripheral swelling 135.08 9.73 2397 494768 267220 78980003
Burning sensation 134.42 9.73 721 496444 57911 79189312
Anaemia 134.00 9.73 1960 495205 443055 78804168
Rash maculo-papular 132.21 9.73 94 497071 55984 79191239
Diarrhoea 131.42 9.73 6726 490439 873763 78373460
Hepatic cytolysis 131.01 9.73 10 497155 27141 79220082
Bone pain 130.20 9.73 689 496476 55053 79192170
Night sweats 129.36 9.73 655 496510 51440 79195783
Full blood count abnormal 127.86 9.73 546 496619 39928 79207295
Shock 125.57 9.73 57 497108 43491 79203732
Altered state of consciousness 125.37 9.73 58 497107 43764 79203459
Asthma 125.19 9.73 1341 495824 133754 79113469
Neuroleptic malignant syndrome 122.74 9.73 14 497151 27545 79219678
Respiratory arrest 122.40 9.73 107 497058 57443 79189780
Angioedema 120.80 9.73 179 496986 75856 79171367
Gastrooesophageal reflux disease 120.65 9.73 1084 496081 103162 79144061
Bone marrow failure 120.05 9.73 86 497079 51021 79196202
Poisoning 120.01 9.73 10 497155 25262 79221961
Cerebral infarction 119.43 9.73 68 497097 45608 79201615
Influenza 118.93 9.73 1284 495881 128322 79118901
Tachycardia 118.74 9.73 637 496528 177131 79070092
Sleep disorder due to a general medical condition 118.66 9.73 270 496895 14007 79233216
Rhinorrhoea 118.60 9.73 847 496318 75227 79171996
Ear pain 116.14 9.73 459 496706 32410 79214813
White blood cell count decreased 115.10 9.73 1730 495435 186558 79060665
Myelosuppression 114.25 9.73 54 497111 40242 79206981
Hypokalaemia 113.79 9.73 486 496679 143554 79103669
Mucosal inflammation 112.39 9.73 186 496979 75394 79171829
Serotonin syndrome 110.79 9.73 72 497093 44955 79202268
Psoriatic arthropathy 110.54 9.73 849 496316 77150 79170073
Intentional self-injury 109.34 9.73 33 497132 32386 79214837
Nasopharyngitis 108.88 9.73 2204 494961 251677 78995546
Urinary tract infection 108.59 9.73 2355 494810 272157 78975066
General physical health deterioration 108.06 9.73 1145 496020 274093 78973130
Leukopenia 106.93 9.73 370 496795 116143 79131080
Hypoglycaemia 106.34 9.73 304 496861 101290 79145933
Inappropriate schedule of product administration 105.17 9.73 1285 495880 132343 79114880
Drug resistance 103.19 9.73 68 497097 42145 79205078
Sepsis 102.49 9.73 1129 496036 268299 78978924
Vitamin D deficiency 102.41 9.73 255 496910 14024 79233199
Hepatic failure 102.30 9.73 139 497026 61073 79186150
Vitamin D decreased 100.55 9.73 201 496964 9524 79237699
Agitation 100.30 9.73 304 496861 99411 79147812
Blood creatine phosphokinase increased 99.81 9.73 161 497004 65929 79181294
Rheumatoid arthritis 98.59 9.73 1837 495328 206633 79040590
Paraesthesia 98.59 9.73 1596 495569 174727 79072496
Toxic skin eruption 97.61 9.73 12 497153 22281 79224942
Full blood count decreased 97.58 9.73 378 496787 26441 79220782
Circulatory collapse 97.17 9.73 57 497108 37611 79209612
Pyrexia 96.92 9.73 3362 493803 675347 78571876
Limb discomfort 96.79 9.73 434 496731 32416 79214807
Sensitisation 96.37 9.73 111 497054 3200 79244023
Melaena 96.09 9.73 144 497021 60746 79186477
Hepatotoxicity 95.93 9.73 107 497058 51245 79195978
Toxic epidermal necrolysis 95.88 9.73 82 497083 44499 79202724
Blood test abnormal 95.70 9.73 285 496880 17425 79229798
Abdominal pain upper 94.61 9.73 1939 495226 221880 79025343
Asthenia 94.59 9.73 3995 493170 507694 78739529
Myocardial infarction 94.15 9.73 716 496449 183413 79063810
Psoriasis 93.35 9.73 911 496254 88676 79158547
Carpal tunnel syndrome 92.33 9.73 300 496865 19228 79227995
Renal impairment 92.25 9.73 590 496575 157193 79090030
Cardiogenic shock 91.49 9.73 76 497089 41838 79205385
Jaundice 91.34 9.73 119 497046 53230 79193993
Sedation 90.67 9.73 114 497051 51781 79195442
Neutropenic sepsis 90.46 9.73 28 497137 27036 79220187
Acute respiratory distress syndrome 90.05 9.73 85 497080 43982 79203241
Polycystic ovaries 87.73 9.73 113 497052 3666 79243557
Mycotic allergy 87.61 9.73 74 497091 1445 79245778
Weight decreased 87.28 9.73 2863 494302 352335 78894888
Anaphylactic shock 85.29 9.73 60 497105 35936 79211287
Hip fracture 84.41 9.73 398 496767 30363 79216860
Stevens-Johnson syndrome 84.28 9.73 72 497093 39094 79208129
Pneumocystis jirovecii pneumonia 84.13 9.73 49 497116 32459 79214764
Nasal congestion 82.49 9.73 784 496381 75768 79171455
Disseminated intravascular coagulation 81.99 9.73 62 497103 35780 79211443
Wheezing 80.87 9.73 1096 496069 115568 79131655
Migraine 80.80 9.73 868 496297 86625 79160598
Cough 80.47 9.73 2918 494247 363871 78883352
Malignant neoplasm progression 80.26 9.73 507 496658 135483 79111740
COVID-19 80.02 9.73 1405 495760 156269 79090954
Ventricular fibrillation 79.99 9.73 50 497115 31876 79215347
Fibromyalgia 79.59 9.73 679 496486 63661 79183562
Acute hepatic failure 78.48 9.73 45 497120 30068 79217155
Extrapyramidal disorder 78.48 9.73 22 497143 22657 79224566
Osteopenia 77.02 9.73 271 496894 18093 79229130
Body height decreased 76.63 9.73 167 496998 8413 79238810
Pollakiuria 75 9.73 443 496722 36874 79210349
Ventricular tachycardia 74.44 9.73 91 497074 41844 79205379
International normalised ratio increased 73.77 9.73 275 496890 84446 79162777
Ejection fraction 72.76 9.73 80 497085 2189 79245034
Hospitalisation 72.75 9.73 903 496262 93333 79153890
Labelled drug-drug interaction medication error 72.52 9.73 41 497124 27609 79219614
Torsade de pointes 72.12 9.73 16 497149 19296 79227927
Gastrointestinal haemorrhage 71.97 9.73 582 496583 147137 79100086
Muscular weakness 71.41 9.73 1403 495762 159326 79087897
Dyspepsia 71.25 9.73 1011 496154 107676 79139547
Dry skin 71.11 9.73 692 496473 67303 79179920
Neurotoxicity 70.93 9.73 59 497106 32459 79214764
Aggression 70.68 9.73 131 497034 50827 79196396
Haematemesis 70.18 9.73 137 497028 52127 79195096
Hot flush 69.39 9.73 582 496583 54295 79192928
Sinus disorder 69.37 9.73 301 496864 22163 79225060
Contusion 69.27 9.73 1308 495857 147468 79099755
Dry mouth 69.05 9.73 846 496319 87173 79160050
Spinal fracture 68.59 9.73 258 496907 17796 79229427
Liver function test abnormal 68.15 9.73 192 496973 64283 79182940
Accidental overdose 68.06 9.73 88 497077 39493 79207730
Blood calcium increased 67.62 9.73 179 496986 10221 79237002
Cytokine release syndrome 67.25 9.73 75 497090 35923 79211300
Colitis ulcerative 66.99 9.73 408 496757 34334 79212889
Osteoarthritis 66.69 9.73 835 496330 86474 79160749
Bronchitis 66.58 9.73 1165 496000 129479 79117744
Hypervitaminosis D 66.49 9.73 25 497140 81 79247142
Haematotoxicity 66.39 9.73 9 497156 15510 79231713
Anuria 66.03 9.73 24 497141 20939 79226284
Blood bilirubin increased 65.83 9.73 203 496962 66029 79181194
Myoclonus 65.68 9.73 46 497119 27614 79219609
Acute generalised exanthematous pustulosis 65.03 9.73 14 497151 17240 79229983
Gait spastic 64.33 9.73 56 497109 1141 79246082
Death 64.07 9.73 2883 494282 563631 78683592
Encephalopathy 63.89 9.73 211 496954 67186 79180037
Neck pain 63.61 9.73 735 496430 74682 79172541
Coronary artery disease 63.44 9.73 203 496962 65271 79181952
Oropharyngeal pain 63.41 9.73 996 496169 108357 79138866
Atypical femur fracture 63.21 9.73 115 497050 5074 79242149
Drug level increased 62.34 9.73 94 497071 39557 79207666
Central nervous system lesion 61.97 9.73 204 496961 13164 79234059
Pruritus 61.69 9.73 3030 494135 391618 78855605
Anaphylactic reaction 61.64 9.73 290 496875 83453 79163770
Medication error 61.61 9.73 220 496945 68422 79178801
Blood lactate dehydrogenase increased 61.45 9.73 93 497072 39077 79208146
Confusional state 61.37 9.73 1511 495654 316486 78930737
Mydriasis 61.26 9.73 17 497148 17626 79229597
Constipation 61.10 9.73 2248 494917 280802 78966421
Injection site pain 60.61 9.73 1142 496023 128696 79118527
Delirium 60.58 9.73 296 496869 84331 79162892
Loss of personal independence in daily activities 60.51 9.73 937 496228 101643 79145580
Injection site pruritus 60.31 9.73 461 496704 41822 79205401
Status epilepticus 60.31 9.73 41 497124 25000 79222223
Ascites 60.24 9.73 254 496911 75308 79171915
Bronchopulmonary aspergillosis 60.01 9.73 32 497133 22262 79224961
Hyperthermia 59.68 9.73 19 497146 18018 79229205
Bone density abnormal 59.60 9.73 84 497081 2976 79244247
Cerebral haemorrhage 59.30 9.73 174 496991 57499 79189724
Respiratory distress 59.27 9.73 177 496988 58162 79189061
Hyperbilirubinaemia 59.25 9.73 40 497125 24478 79222745
Eosinophilia 59.05 9.73 121 497044 45224 79201999
Blood cholesterol increased 59.03 9.73 789 496376 82931 79164292
Hepatitis 58.12 9.73 167 496998 55560 79191663
Nephrolithiasis 57.52 9.73 546 496619 52745 79194478
Miosis 57.14 9.73 14 497151 15775 79231448
Febrile bone marrow aplasia 57.02 9.73 7 497158 13013 79234210
Loss of consciousness 56.78 9.73 722 496443 167221 79080002
Dizziness 55.39 9.73 3901 493264 522540 78724683
Micturition urgency 55.14 9.73 189 496976 12452 79234771
Cardiotoxicity 55.05 9.73 6 497159 12233 79234990
Injection site erythema 54.74 9.73 736 496429 77461 79169762
Erythema multiforme 54.27 9.73 21 497144 17630 79229593
Musculoskeletal stiffness 54.15 9.73 1452 495713 173556 79073667
Bowel movement irregularity 53.99 9.73 121 497044 6213 79241010
Therapeutic product effect incomplete 53.97 9.73 1209 495956 140436 79106787
Cystic fibrosis 53.76 9.73 91 497074 3789 79243434
Pleural effusion 53.48 9.73 613 496552 144649 79102574
Respiratory depression 53.35 9.73 56 497109 27574 79219649
Gait inability 53.23 9.73 582 496583 58335 79188888
Respiratory tract congestion 53.16 9.73 256 496909 19698 79227525
Productive cough 52.92 9.73 809 496356 87522 79159701
Sleep apnoea syndrome 52.75 9.73 399 496766 36079 79211144
Balance disorder 52.33 9.73 887 496278 97970 79149253
Posterior reversible encephalopathy syndrome 52.18 9.73 52 497113 26229 79220994
Taste disorder 51.95 9.73 216 496949 15607 79231616
Ejection fraction decreased 51.48 9.73 85 497080 34492 79212731
Acute myocardial infarction 51.43 9.73 276 496889 76760 79170463
Pathogen resistance 51.35 9.73 13 497152 14329 79232894
Plasma cell myeloma 51.33 9.73 533 496632 52726 79194497
Brain oedema 51.30 9.73 49 497116 25214 79222009
Inappropriate antidiuretic hormone secretion 51.18 9.73 53 497112 26260 79220963
Haemophagocytic lymphohistiocytosis 50.95 9.73 37 497128 21800 79225423
Exposure during pregnancy 50.85 9.73 395 496770 100737 79146486
Shock haemorrhagic 50.83 9.73 31 497134 20029 79227194
Post transplant lymphoproliferative disorder 50.61 9.73 6 497159 11458 79235765
Cystitis 50.48 9.73 527 496638 52205 79195018
Lower limb fracture 50.19 9.73 281 496884 22934 79224289
Needle fatigue 50.10 9.73 43 497122 859 79246364
Relapsing-remitting multiple sclerosis 49.48 9.73 54 497111 1465 79245758
Psychotic disorder 49.36 9.73 116 497049 41286 79205937
Bone density decreased 49.27 9.73 189 496976 13158 79234065
Frequent bowel movements 49.03 9.73 334 496831 29205 79218018
Cyanosis 48.66 9.73 51 497114 25131 79222092
Prescribed underdose 48.56 9.73 333 496832 29181 79218042
Sneezing 48.52 9.73 247 496918 19436 79227787
Red blood cell count decreased 48.27 9.73 560 496605 56953 79190270
Bone giant cell tumour 48.26 9.73 17 497148 43 79247180
Urine leukocyte esterase positive 47.74 9.73 89 497076 4002 79243221
Haemodialysis 47.56 9.73 27 497138 18141 79229082
Hyperglycaemia 47.50 9.73 251 496914 70084 79177139
Gamma-glutamyltransferase increased 47.26 9.73 178 496987 54502 79192721
Injection site mass 46.79 9.73 249 496916 19935 79227288
Seizure 46.69 9.73 862 496303 187972 79059251
Injection site reaction 46.68 9.73 535 496630 54250 79192973
Dysgeusia 46.34 9.73 553 496612 56624 79190599
Hernia 46.28 9.73 220 496945 16839 79230384
Hypertensive crisis 46.15 9.73 37 497128 20733 79226490
Alanine aminotransferase increased 46.06 9.73 724 496441 161846 79085377
Illness 46.03 9.73 468 496697 46043 79201180
Acute myeloid leukaemia 45.91 9.73 76 497089 30809 79216414
Wrist fracture 45.82 9.73 171 496994 11750 79235473
Aspartate aminotransferase increased 45.76 9.73 599 496566 138042 79109181
Therapy partial responder 45.33 9.73 26 497139 17371 79229852
Glaucoma 45.27 9.73 243 496922 19518 79227705
Haemodynamic instability 45.26 9.73 26 497139 17356 79229867
Disorientation 45.26 9.73 219 496946 62557 79184666
Transaminases increased 45.01 9.73 168 496997 51575 79195648
Angina pectoris 44.98 9.73 168 496997 51564 79195659
Injection site bruising 44.70 9.73 421 496744 40581 79206642
Myocardial ischaemia 44.64 9.73 56 497109 25463 79221760
Tumour lysis syndrome 44.58 9.73 50 497115 23889 79223334
Urine abnormality 44.15 9.73 132 497033 8087 79239136
Blood parathyroid hormone increased 44.08 9.73 78 497087 3367 79243856
Dystonia 44.05 9.73 41 497124 21358 79225865
Flatulence 43.78 9.73 433 496732 42291 79204932
Thrombotic microangiopathy 43.49 9.73 37 497128 20132 79227091
Lip dry 43.41 9.73 201 496964 15217 79232006
Therapy cessation 43.13 9.73 390 496775 37172 79210051
Face oedema 42.99 9.73 68 497097 28068 79219155
Sedation complication 42.90 9.73 22 497143 15647 79231576
Oral pain 42.76 9.73 342 496823 31456 79215767
Bone lesion 42.76 9.73 106 497059 5813 79241410
Aspergillus infection 42.74 9.73 34 497131 19127 79228096
Abdominal distension 42.71 9.73 1012 496153 118638 79128585
Mobility decreased 42.59 9.73 1030 496135 121145 79126078
Syncope 42.56 9.73 825 496340 178624 79068599
Alopecia 42.54 9.73 1806 495359 229549 79017674
Electrocardiogram QRS complex prolonged 42.48 9.73 8 497157 10825 79236398
Nephropathy toxic 42.17 9.73 39 497126 20380 79226843
Hypercalcaemia 42.10 9.73 395 496770 38035 79209188
Coagulopathy 42.04 9.73 102 497063 35904 79211319
Cataract 41.97 9.73 581 496584 61539 79185684
Tubulointerstitial nephritis 41.79 9.73 112 497053 38123 79209100
Epstein-Barr virus infection 41.36 9.73 19 497146 14397 79232826
Suspected suicide 41.07 9.73 8 497157 10568 79236655
Jaundice cholestatic 40.85 9.73 10 497155 11274 79235949
Nausea 40.76 9.73 6674 490491 950522 78296701
Bronchial wall thickening 40.72 9.73 65 497100 2576 79244647
Flushing 40.71 9.73 775 496390 87493 79159730
Myalgia 40.66 9.73 1477 495688 184164 79063059
Contraindicated product administered 40.24 9.73 715 496450 156823 79090400
Ischaemic stroke 40.16 9.73 92 497073 33039 79214184
Left ventricular dysfunction 39.96 9.73 37 497128 19324 79227899
Breast cancer 39.94 9.73 353 496812 33428 79213795
Ankle fracture 39.79 9.73 210 496955 16759 79230464
Vitamin D increased 39.64 9.73 32 497133 585 79246638
Stress fracture 39.59 9.73 109 497056 6371 79240852
Pathological fracture 39.55 9.73 150 497015 10387 79236836
Pulmonary mass 39.44 9.73 313 496852 28721 79218502
Orthostatic hypotension 39.30 9.73 198 496967 55966 79191257
Hypervitaminosis 38.97 9.73 13 497152 26 79247197
Thoracic vertebral fracture 38.93 9.73 95 497070 5158 79242065
Weight increased 38.86 9.73 2108 495057 275278 78971945
Upper respiratory tract infection 38.86 9.73 791 496374 90377 79156846
Pulmonary oedema 38.83 9.73 357 496808 87897 79159326
Sciatica 38.69 9.73 346 496819 32876 79214347
Drug eruption 38.64 9.73 142 497023 43793 79203430
Mucormycosis 38.48 9.73 4 497161 8465 79238758
Drug-induced liver injury 38.23 9.73 248 496917 65869 79181354
Bone loss 37.97 9.73 62 497103 2505 79244718
Arrhythmia 37.93 9.73 225 496940 61047 79186176
Haematuria 37.89 9.73 262 496903 68574 79178649
Off label use 37.87 9.73 6319 490846 900896 78346327
Chills 37.85 9.73 1286 495879 158948 79088275
Sudden death 37.73 9.73 51 497114 22460 79224763
Intramedullary rod insertion 37.52 9.73 20 497145 172 79247051
JC polyomavirus test positive 37.34 9.73 48 497117 1554 79245669
Akathisia 37.23 9.73 18 497147 13241 79233982
Infusion related reaction 37.12 9.73 1122 496043 229115 79018108
Haematoma 37.10 9.73 183 496982 52012 79195211
Blood pressure increased 37.09 9.73 1642 495523 209718 79037505
Intentional product misuse 36.84 9.73 397 496768 94768 79152455
Substance abuse 36.81 9.73 10 497155 10516 79236707
Intervertebral disc degeneration 36.77 9.73 195 496970 15590 79231633
Sinus congestion 36.69 9.73 231 496934 19665 79227558
Blood pressure abnormal 36.57 9.73 207 496958 16962 79230261
Pallor 36.46 9.73 174 496991 49888 79197335
Pancreatitis acute 36.37 9.73 172 496993 49432 79197791
Schizophrenia 36.23 9.73 26 497139 15414 79231809
Bronchial neoplasm 36.19 9.73 28 497137 480 79246743
Stress 36.03 9.73 697 496468 78915 79168308
Subarachnoid haemorrhage 35.63 9.73 61 497104 24404 79222819
Deep vein thrombosis postoperative 35.47 9.73 147 497018 10605 79236618
Hepatitis acute 35.40 9.73 27 497138 15515 79231708
Hypertransaminasaemia 35.34 9.73 15 497150 11909 79235314
Rhinitis allergic 35.32 9.73 161 497004 12108 79235115
Upper limb fracture 35.27 9.73 212 496953 17755 79229468
Abdominal discomfort 35.24 9.73 1906 495259 248821 78998402
Dry throat 35.19 9.73 117 497048 7589 79239634
Musculoskeletal discomfort 35.16 9.73 228 496937 19607 79227616
Seasonal allergy 35.08 9.73 198 496967 16208 79231015
Coma scale abnormal 34.91 9.73 6 497159 8672 79238551
Dermatitis exfoliative 34.79 9.73 12 497153 10817 79236406
Colorectal cancer 34.74 9.73 6 497159 8641 79238582
Transplant rejection 34.68 9.73 42 497123 19395 79227828
Skin haemorrhage 34.33 9.73 157 497008 11824 79235399
Acute coronary syndrome 34.29 9.73 49 497116 21084 79226139
Upper gastrointestinal haemorrhage 34.29 9.73 137 497028 41243 79205980
Skin discolouration 34.19 9.73 399 496766 40635 79206588
Dry eye 33.90 9.73 366 496799 36565 79210658
Acute graft versus host disease in skin 33.83 9.73 4 497161 7654 79239569
Nasal turbinate hypertrophy 33.58 9.73 31 497134 684 79246539
Mixed liver injury 33.37 9.73 4 497161 7574 79239649
Lumbar vertebral fracture 33.31 9.73 108 497057 6914 79240309
Calciphylaxis 33.24 9.73 73 497092 3697 79243526
Paraesthesia oral 33.10 9.73 230 496935 20241 79226982
Road traffic accident 33.08 9.73 417 496748 43247 79203976
Foot fracture 32.67 9.73 242 496923 21739 79225484
Depression 32.47 9.73 1658 495507 215132 79032091
Endometriosis 32.31 9.73 71 497094 3597 79243626
Ejection fraction abnormal 32.20 9.73 56 497109 2384 79244839
Vision blurred 31.99 9.73 876 496289 105022 79142201
Ear infection 31.50 9.73 341 496824 34091 79213132
Endometrial ablation 31.29 9.73 33 497132 860 79246363
Secondary progressive multiple sclerosis 31.23 9.73 41 497124 1356 79245867
Clostridium difficile infection 31.22 9.73 405 496760 42280 79204943
Vitamin B12 decreased 31.05 9.73 68 497097 3437 79243786
Cytomegalovirus infection reactivation 31.02 9.73 8 497157 8708 79238515
Bronchospasm 30.97 9.73 68 497097 24791 79222432
Injection site urticaria 30.95 9.73 160 497005 12666 79234557
Diverticulitis 30.77 9.73 429 496736 45507 79201716
Graft versus host disease 30.68 9.73 29 497136 14997 79232226
Hallucination, visual 30.65 9.73 103 497062 32626 79214597
Generalised tonic-clonic seizure 30.60 9.73 155 497010 43755 79203468
Atrioventricular block complete 30.59 9.73 35 497130 16575 79230648
Pulmonary haemorrhage 30.52 9.73 28 497137 14689 79232534
Pre-existing condition improved 30.51 9.73 90 497075 5473 79241750
Rib fracture 30.48 9.73 287 496878 27660 79219563
Cyst 30.23 9.73 168 496997 13672 79233551
Thyroid disorder 30.16 9.73 170 496995 13909 79233314
Acne 30.04 9.73 280 496885 26910 79220313
Purpura 30.01 9.73 47 497118 19480 79227743
Hepatic enzyme abnormal 29.99 9.73 112 497053 7698 79239525
Tooth extraction 29.97 9.73 142 497023 10853 79236370
Multiple allergies 29.92 9.73 137 497028 10323 79236900
Dermatitis atopic 29.73 9.73 133 497032 9923 79237300
Respiratory disorder 29.68 9.73 418 496747 44438 79202785
Arthritis 29.44 9.73 931 496234 113949 79133274
Hypothermia 29.36 9.73 61 497104 22685 79224538
Surgery 29.28 9.73 323 496842 32443 79214780
Hepatitis fulminant 29.26 9.73 5 497160 7257 79239966
Haemolytic anaemia 29.23 9.73 41 497124 17779 79229444
Angina unstable 29.19 9.73 36 497129 16491 79230732
Spinal operation 29.13 9.73 112 497053 7805 79239418
Sinus bradycardia 29.10 9.73 72 497093 25175 79222048
Muscle tightness 29.04 9.73 158 497007 12756 79234467
Gastrointestinal pain 28.88 9.73 130 497035 9725 79237498
Poor venous access 28.81 9.73 203 496962 17946 79229277
Blood pressure diastolic abnormal 28.78 9.73 47 497118 19155 79228068
Venoocclusive liver disease 28.71 9.73 19 497146 11752 79235471
Body temperature increased 28.62 9.73 412 496753 44008 79203215
Abnormal faeces 28.60 9.73 108 497057 7463 79239760
Encephalitis 28.40 9.73 30 497135 14730 79232493
Hypoacusis 28.23 9.73 300 496865 29850 79217373
Rheumatic fever 28.21 9.73 287 496878 28238 79218985
Drug ineffective for unapproved indication 28.21 9.73 195 496970 51043 79196180
Aplasia 28.17 9.73 7 497158 7813 79239410
Pulmonary function test decreased 28.07 9.73 108 497057 7529 79239694
Cystitis haemorrhagic 28.05 9.73 11 497154 9161 79238062
Epilepsy 28.04 9.73 145 497020 40715 79206508
Pemphigus 28.02 9.73 444 496721 99138 79148085
Urine analysis abnormal 28.02 9.73 97 497068 6423 79240800
Injection site swelling 27.96 9.73 431 496734 46701 79200522
Osteomalacia 27.90 9.73 40 497125 1440 79245783
Thrombosis 27.81 9.73 704 496461 83396 79163827
Drug dependence 27.80 9.73 145 497020 40624 79206599
Blepharospasm 27.76 9.73 90 497075 5761 79241462
Therapeutic response unexpected 27.63 9.73 216 496949 19730 79227493
Pancreatic neuroendocrine tumour 27.40 9.73 27 497138 648 79246575
Dental implantation 27.25 9.73 25 497140 547 79246676
Product use in unapproved indication 27.22 9.73 1279 495886 249080 78998143
Toxic encephalopathy 27.19 9.73 19 497146 11421 79235802
Bradypnoea 27.14 9.73 3 497162 6049 79241174
Hypertonic bladder 27.00 9.73 72 497093 4129 79243094
Eye infection 26.91 9.73 146 497019 11774 79235449
Oesophageal carcinoma 26.89 9.73 18 497147 11066 79236157
Urticaria 26.83 9.73 1412 495753 183789 79063434
Fracture displacement 26.68 9.73 37 497128 1291 79245932
Tooth fracture 26.56 9.73 142 497023 11388 79235835
Pulmonary tuberculosis 26.53 9.73 8 497157 7857 79239366
Invasive ductal breast carcinoma 26.50 9.73 89 497076 5803 79241420
Autoimmune disorder 26.48 9.73 186 496979 16426 79230797
Ketoacidosis 26.47 9.73 8 497157 7846 79239377
Oliguria 26.28 9.73 38 497127 16271 79230952
Hallucination, auditory 26.28 9.73 56 497109 20637 79226586
Procedural pain 26.15 9.73 239 496926 22845 79224378
Gastrointestinal toxicity 26.03 9.73 9 497156 8100 79239123
Nephrectomy 25.92 9.73 47 497118 2068 79245155
Urine odour abnormal 25.81 9.73 92 497073 6181 79241042
Injection site rash 25.74 9.73 196 496969 17758 79229465
Enterococcal infection 25.72 9.73 36 497129 15624 79231599
Appetite disorder 25.68 9.73 106 497059 7633 79239590
Obstruction 25.68 9.73 75 497090 4535 79242688
Ileus paralytic 25.61 9.73 14 497151 9606 79237617
Skin toxicity 25.38 9.73 10 497155 8304 79238919
Acute graft versus host disease 25.36 9.73 16 497149 10151 79237072
Bone cyst 25.35 9.73 62 497103 3371 79243852
Unresponsive to stimuli 25.26 9.73 224 496941 55564 79191659
Hair texture abnormal 25.22 9.73 63 497102 3471 79243752
Dermatitis bullous 25.19 9.73 31 497134 14214 79233009
Mean cell haemoglobin increased 25.12 9.73 71 497094 4214 79243009
Hospice care 25.06 9.73 129 497036 10195 79237028
Dysstasia 25.02 9.73 274 496891 27472 79219751
Lymphocyte count decreased 24.90 9.73 424 496741 46865 79200358
Bone marrow oedema 24.87 9.73 41 497124 1670 79245553
Hypomania 24.86 9.73 8 497157 7536 79239687
Respiratory acidosis 24.82 9.73 20 497145 11180 79236043
Toothache 24.82 9.73 211 496954 19759 79227464
Crying 24.81 9.73 236 496929 22807 79224416
Condition aggravated 24.71 9.73 3524 493641 497600 78749623
Nocturia 24.71 9.73 158 497007 13523 79233700
Hypersomnia 24.64 9.73 236 496929 22850 79224373
Facet joint syndrome 24.56 9.73 137 497028 11165 79236058
Tooth disorder 24.55 9.73 261 496904 25972 79221251
Creatinine renal clearance decreased 24.49 9.73 51 497114 18951 79228272
Coronary artery stenosis 24.44 9.73 25 497140 12459 79234764
Pleural thickening 24.34 9.73 56 497109 2926 79244297
Sinus tachycardia 24.21 9.73 133 497032 36775 79210448
Tachypnoea 24.20 9.73 110 497055 31953 79215270
Ileus 24.19 9.73 83 497082 26128 79221095
C-reactive protein increased 24.06 9.73 616 496549 128411 79118812
Polyneuropathy 24.01 9.73 74 497091 24077 79223146
Intraductal proliferative breast lesion 23.99 9.73 50 497115 2441 79244782
Macular degeneration 23.93 9.73 136 497029 11160 79236063
Cytomegalovirus chorioretinitis 23.93 9.73 3 497162 5487 79241736
Foreign body in reproductive tract 23.88 9.73 25 497140 646 79246577
Acidosis 23.85 9.73 55 497110 19707 79227516
Rhonchi 23.78 9.73 67 497098 3969 79243254
Congestive cardiomyopathy 23.74 9.73 23 497142 11757 79235466
Product monitoring error 23.65 9.73 13 497152 8893 79238330
Infusion site extravasation 23.63 9.73 125 497040 9983 79237240
Blood iron decreased 23.55 9.73 171 496994 15263 79231960
Blood magnesium decreased 23.53 9.73 180 496985 16332 79230891
Muscle rigidity 23.46 9.73 56 497109 19826 79227397
Faecal calprotectin increased 23.43 9.73 82 497083 5459 79241764
Exposure to toxic agent 23.42 9.73 14 497151 9144 79238079
Myopathy 23.42 9.73 59 497106 20504 79226719
Intentional dose omission 23.40 9.73 113 497052 8704 79238519
Psychomotor retardation 23.34 9.73 5 497160 6179 79241044
BK virus infection 23.17 9.73 13 497152 8791 79238432
Hepatic necrosis 23.15 9.73 14 497151 9086 79238137
Viral infection 23.13 9.73 387 496778 42629 79204594
Lacrimation increased 23.12 9.73 228 496937 22249 79224974
Heparin-induced thrombocytopenia 23.12 9.73 16 497149 9666 79237557
Colitis microscopic 23.05 9.73 130 497035 10638 79236585
Mean cell haemoglobin concentration abnormal 23.04 9.73 14 497151 158 79247065
Bladder cancer 23.04 9.73 55 497110 19471 79227752
Mite allergy 22.83 9.73 33 497132 1197 79246026
Pulseless electrical activity 22.81 9.73 33 497132 14127 79233096
Immunosuppressant drug level increased 22.80 9.73 14 497151 9013 79238210
Gastric cancer 22.78 9.73 18 497147 10161 79237062
Spirometry abnormal 22.77 9.73 29 497136 930 79246293
Anxiety 22.77 9.73 1822 495343 246690 79000533
Nocardiosis 22.68 9.73 4 497161 5675 79241548
Parkinsonism 22.67 9.73 43 497122 16541 79230682
Compression fracture 22.65 9.73 90 497075 6370 79240853
Hepatitis cholestatic 22.59 9.73 32 497133 13820 79233403
Adrenal insufficiency 22.55 9.73 96 497069 28391 79218832
Blood calcium abnormal 22.54 9.73 35 497130 1354 79245869
Oxygen saturation decreased 22.51 9.73 622 496543 128425 79118798
Blood urea increased 22.49 9.73 195 496970 48595 79198628
Diabetic ketoacidosis 22.36 9.73 123 497042 33999 79213224
Lymphoproliferative disorder 22.33 9.73 4 497161 5611 79241612
Head discomfort 22.32 9.73 161 497004 14341 79232882
Myelodysplastic syndrome 22.25 9.73 105 497060 30196 79217027
Hyperlactacidaemia 22.22 9.73 4 497161 5591 79241632
Metabolic disorder 22.10 9.73 15 497150 9155 79238068
Erysipelas 22.08 9.73 21 497144 10829 79236394
Arthropod bite 22.08 9.73 108 497057 8363 79238860
Leukoencephalopathy 21.91 9.73 11 497154 7918 79239305
Peroneal nerve palsy 21.85 9.73 85 497080 5957 79241266
Insurance issue 21.84 9.73 82 497083 5651 79241572
Multiple-drug resistance 21.78 9.73 14 497151 8794 79238429
Isosthenuria 21.77 9.73 12 497153 111 79247112
Colitis ischaemic 21.73 9.73 39 497126 15320 79231903
Femur fracture 21.62 9.73 350 496815 38302 79208921
Product prescribing error 21.61 9.73 177 496988 44636 79202587
Pain in jaw 21.54 9.73 406 496759 45745 79201478
Transplant dysfunction 21.53 9.73 9 497156 7212 79240011
Adenovirus infection 21.48 9.73 13 497152 8434 79238789
Peripheral sensory neuropathy 21.37 9.73 30 497135 13003 79234220
Sinus headache 21.33 9.73 75 497090 5005 79242218
Recalled product 21.33 9.73 28 497137 926 79246297
Renal tubular necrosis 21.32 9.73 82 497083 24957 79222266
Intestinal ischaemia 21.30 9.73 31 497134 13239 79233984
Skin exfoliation 21.19 9.73 471 496694 54629 79192594
Bradyphrenia 21.18 9.73 21 497144 10619 79236604
Acute pulmonary oedema 21.17 9.73 35 497130 14195 79233028
Activated partial thromboplastin time prolonged 21.16 9.73 35 497130 14193 79233030
Nervousness 21.16 9.73 309 496856 33106 79214117
Hypoxia 21.14 9.73 486 496679 102757 79144466
Torus fracture 21.10 9.73 11 497154 90 79247133
Drug use disorder 21.05 9.73 14 497151 8637 79238586
Abortion induced 20.97 9.73 9 497156 7100 79240123
Nephritic syndrome 20.93 9.73 19 497146 410 79246813
Hyperpyrexia 20.91 9.73 6 497159 6086 79241137
Somnolence 20.86 9.73 1248 495917 237733 79009490
Unintentional medical device removal 20.86 9.73 11 497154 7701 79239522
Drug screen positive 20.76 9.73 6 497159 6057 79241166
Osteoporosis 20.64 9.73 462 496703 53650 79193573
Myocarditis 20.62 9.73 68 497097 21665 79225558
Ingrowing nail 20.58 9.73 51 497114 2796 79244427
Cutaneous vasculitis 20.57 9.73 13 497152 8239 79238984
Chest discomfort 20.50 9.73 1055 496110 136989 79110234
Neuralgia 20.47 9.73 307 496858 33077 79214146
Product administration interrupted 20.36 9.73 62 497103 3837 79243386
Oral discomfort 20.35 9.73 117 497048 9643 79237580
Palmar-plantar erythrodysaesthesia syndrome 20.33 9.73 122 497043 33012 79214211
Carotid artery thrombosis 20.31 9.73 53 497112 3000 79244223
Ankylosing spondylitis 20.25 9.73 138 497027 12067 79235156
Tachyarrhythmia 20.25 9.73 9 497156 6953 79240270
Disease progression 20.20 9.73 941 496224 183421 79063802
Peritonitis 20.09 9.73 98 497067 27938 79219285
Gastroenteritis viral 20.04 9.73 240 496925 24591 79222632
Hyperammonaemic encephalopathy 19.93 9.73 3 497162 4779 79242444
Malaise 19.88 9.73 3408 493757 486461 78760762
Sensory loss 19.86 9.73 144 497021 12847 79234376
Cataract operation 19.61 9.73 74 497091 5111 79242112
Essential hypertension 19.38 9.73 82 497083 5971 79241252
Tooth infection 19.36 9.73 191 496974 18641 79228582
Joint swelling 19.31 9.73 2069 495096 286577 78960646
Upper-airway cough syndrome 19.27 9.73 132 497033 11561 79235662
Nephrocalcinosis 19.21 9.73 34 497131 1468 79245755
Restlessness 19.20 9.73 191 496974 46301 79200922
Cervix neoplasm 19.14 9.73 13 497152 180 79247043
Anti-transglutaminase antibody increased 19.06 9.73 6 497159 9 79247214
Collagen-vascular disease 19.06 9.73 10 497155 83 79247140
Nephrotic syndrome 19.05 9.73 25 497140 11149 79236074
Stress cardiomyopathy 19.01 9.73 25 497140 11141 79236082
Wrong patient received product 19.01 9.73 3 497162 4615 79242608
Pemphigoid 18.99 9.73 42 497123 15273 79231950
Increased tendency to bruise 18.99 9.73 121 497044 10343 79236880
Cholecystectomy 18.97 9.73 112 497053 9320 79237903
Intentional product use issue 18.96 9.73 1144 496021 150968 79096255
Cardiac failure congestive 18.94 9.73 711 496454 141691 79105532
Tonsillar ulcer 18.92 9.73 18 497147 413 79246810
Neutropenic colitis 18.90 9.73 6 497159 5701 79241522
Ventricular hypokinesia 18.84 9.73 18 497147 9261 79237962
Lymphocyte percentage decreased 18.81 9.73 71 497094 4905 79242318
Cardiovascular disorder 18.81 9.73 54 497111 17971 79229252
Chronic disease 18.78 9.73 12 497153 149 79247074
Dysphonia 18.77 9.73 476 496689 56396 79190827
Ageusia 18.74 9.73 172 496993 16460 79230763
Atrioventricular block 18.68 9.73 37 497128 14004 79233219
Enterocolitis 18.66 9.73 39 497126 14473 79232750
Cytomegalovirus viraemia 18.64 9.73 32 497133 12789 79234434
Rheumatoid factor positive 18.64 9.73 497 496668 59342 79187881
Therapeutic reaction time decreased 18.59 9.73 56 497109 3445 79243778
Retroperitoneal haematoma 18.59 9.73 5 497160 5292 79241931
Haemorrhage intracranial 18.52 9.73 92 497073 26101 79221122
Poor quality sleep 18.51 9.73 220 496945 22502 79224721
Hypernatraemia 18.44 9.73 39 497126 14412 79232811
Monocyte percentage increased 18.36 9.73 41 497124 2100 79245123
Swollen joint count increased 18.25 9.73 221 496944 22706 79224517
Weight fluctuation 18.19 9.73 130 497035 11545 79235678
Musculoskeletal pain 18.12 9.73 796 496369 101558 79145665
Gastric haemorrhage 18.07 9.73 42 497123 15008 79232215
Pulmonary embolism 18.03 9.73 880 496285 170774 79076449
Pericarditis 18.03 9.73 503 496662 103733 79143490
Hypomagnesaemia 18.03 9.73 196 496969 46715 79200508
Urine ketone body present 17.98 9.73 56 497109 3509 79243714
Milk-alkali syndrome 17.97 9.73 32 497133 1388 79245835
Device use error 17.96 9.73 11 497154 7090 79240133
Intentional underdose 17.90 9.73 43 497122 2311 79244912
Red cell distribution width increased 17.88 9.73 159 497006 15083 79232140
Neurologic neglect syndrome 17.86 9.73 49 497116 2858 79244365
Sputum purulent 17.85 9.73 31 497134 1318 79245905
Hepatitis toxic 17.79 9.73 5 497160 5142 79242081
Visual impairment 17.78 9.73 723 496442 91408 79155815
Bladder operation 17.77 9.73 25 497140 884 79246339
Electrolyte imbalance 17.76 9.73 116 497049 30765 79216458
Blood potassium decreased 17.70 9.73 397 496768 46115 79201108
Meralgia paraesthetica 17.66 9.73 19 497146 507 79246716
Eye swelling 17.65 9.73 247 496918 26221 79221002
Refusal of treatment by patient 17.61 9.73 18 497147 8973 79238250
Hand deformity 17.58 9.73 503 496662 103416 79143807
Pneumothorax 17.53 9.73 104 497061 28219 79219004
Electrocardiogram PR shortened 17.46 9.73 15 497150 300 79246923
Blood lactic acid increased 17.46 9.73 33 497132 12711 79234512
Systemic lupus erythematosus 17.45 9.73 599 496566 120550 79126673
Cardiac failure acute 17.43 9.73 60 497105 18869 79228354
Premature labour 17.36 9.73 16 497149 8374 79238849
Complications of transplanted kidney 17.34 9.73 9 497156 6357 79240866
Cell death 17.33 9.73 4 497161 4695 79242528
Immune system disorder 17.30 9.73 123 497042 10906 79236317
Hepatomegaly 17.26 9.73 60 497105 18814 79228409
Cardiomegaly 17.26 9.73 95 497070 26257 79220966
Proteinuria 17.25 9.73 125 497040 32377 79214846
Hypercalciuria 17.25 9.73 19 497146 521 79246702
Dermatitis exfoliative generalised 17.25 9.73 12 497153 7229 79239994
Klebsiella infection 17.22 9.73 46 497119 15674 79231549
Ventricular hypertrophy 17.20 9.73 11 497154 6927 79240296
Accidental death 17.19 9.73 3 497162 4288 79242935
Amyloid related imaging abnormality-oedema/effusion 17.18 9.73 17 497148 410 79246813
Peripheral venous disease 17.16 9.73 163 497002 15746 79231477
Diffuse large B-cell lymphoma 17.05 9.73 31 497134 12118 79235105
Brain death 17.05 9.73 7 497158 5670 79241553
Respiratory symptom 17.00 9.73 67 497098 4724 79242499
Back disorder 16.94 9.73 127 497038 11451 79235772
Cardiac failure chronic 16.93 9.73 27 497138 11108 79236115
Pneumonia cytomegaloviral 16.86 9.73 5 497160 4964 79242259
Renal disorder 16.85 9.73 362 496803 41743 79205480
Accidental exposure to product 16.85 9.73 120 497045 31202 79216021
Nicotine dependence 16.83 9.73 25 497140 930 79246293
Vertebral wedging 16.81 9.73 6 497159 16 79247207
Renal injury 16.73 9.73 52 497113 16875 79230348
Onychoclasis 16.66 9.73 74 497091 5504 79241719
Trichorrhexis 16.64 9.73 23 497142 800 79246423
Catatonia 16.62 9.73 18 497147 8738 79238485
Hyperparathyroidism 16.59 9.73 51 497114 3173 79244050
Wrong product administered 16.59 9.73 19 497146 8993 79238230
Mitral valve incompetence 16.58 9.73 107 497058 28458 79218765
Pneumonitis 16.57 9.73 273 496892 60587 79186636
Throat clearing 16.57 9.73 45 497120 2609 79244614
Gastrointestinal disorder 16.56 9.73 926 496239 121279 79125944
Persecutory delusion 16.55 9.73 5 497160 4904 79242319
Presbyacusis 16.51 9.73 45 497120 2615 79244608
Chronic graft versus host disease 16.47 9.73 11 497154 6770 79240453
Infusion site swelling 16.43 9.73 94 497071 7732 79239491
Large intestine perforation 16.43 9.73 42 497123 14525 79232698
Pulmonary toxicity 16.36 9.73 35 497130 12879 79234344
Paranoia 16.31 9.73 64 497101 19368 79227855
Pulmonary alveolar haemorrhage 16.29 9.73 29 497136 11428 79235795
Right atrial hypertrophy 16.27 9.73 22 497143 749 79246474
Hyperexplexia 16.26 9.73 7 497158 35 79247188
Tuberculosis 16.25 9.73 45 497120 15153 79232070
Sleep disorder 16.22 9.73 671 496494 85006 79162217
Adverse drug reaction 16.21 9.73 535 496630 65857 79181366
Subdural haematoma 16.16 9.73 122 497043 31312 79215911
Immediate post-injection reaction 16.14 9.73 15 497150 334 79246889
Laryngeal pain 16.13 9.73 9 497156 6105 79241118
Cardiac disorder 16.09 9.73 530 496635 65227 79181996
Blood 25-hydroxycholecalciferol increased 16.09 9.73 5 497160 7 79247216
Pneumatosis intestinalis 16.05 9.73 10 497155 6387 79240836
Conjunctivitis allergic 15.96 9.73 34 497131 1686 79245537
Joint range of motion decreased 15.95 9.73 294 496871 32988 79214235
Drug withdrawal syndrome 15.89 9.73 139 497026 34579 79212644
Hepatic encephalopathy 15.89 9.73 87 497078 24079 79223144
Hypertension 15.85 9.73 2324 494841 328668 78918555
Blood magnesium increased 15.80 9.73 53 497112 3453 79243770
Conjunctival hyperaemia 15.80 9.73 4 497161 4409 79242814
Heart rate irregular 15.78 9.73 289 496876 32390 79214833
Hypovolaemic shock 15.78 9.73 33 497132 12243 79234980
Pelvic fracture 15.73 9.73 130 497035 12074 79235149
Metastases to central nervous system 15.70 9.73 51 497114 16324 79230899
Skin atrophy 15.70 9.73 74 497091 5644 79241579
Movement disorder 15.68 9.73 248 496917 27011 79220212
Frustration tolerance decreased 15.68 9.73 90 497075 7412 79239811
Musculoskeletal chest pain 15.68 9.73 229 496936 24535 79222688
Carbohydrate antigen 125 increased 15.66 9.73 39 497126 2145 79245078
Heart rate abnormal 15.63 9.73 77 497088 5980 79241243
Spinal compression fracture 15.53 9.73 168 496997 16790 79230433
Atrial tachycardia 15.48 9.73 13 497152 7120 79240103
Carbohydrate antigen 15-3 increased 15.48 9.73 27 497138 1152 79246071
Systemic infection 15.44 9.73 23 497142 9729 79237494
Cerebral haematoma 15.44 9.73 16 497149 7926 79239297
Mantle cell lymphoma stage IV 15.39 9.73 8 497157 65 79247158
Lung consolidation 15.27 9.73 20 497145 8927 79238296
Blood culture positive 15.27 9.73 18 497147 8411 79238812
Gastrointestinal infection 15.26 9.73 123 497042 11338 79235885
Polyomavirus-associated nephropathy 15.26 9.73 8 497157 5619 79241604
Hyperplastic cholecystopathy 15.26 9.73 12 497153 211 79247012
Rash pruritic 15.20 9.73 568 496597 71061 79176162
Synovitis 15.20 9.73 776 496389 149958 79097265
Patient elopement 15.19 9.73 8 497157 67 79247156
Cervical vertebral fracture 15.18 9.73 54 497111 3624 79243599
Palpitations 15.18 9.73 949 496216 125661 79121562
Nail bed disorder 15.17 9.73 13 497152 259 79246964
Tibia fracture 15.17 9.73 70 497095 5291 79241932
Infusion site pain 15.17 9.73 145 497020 14031 79233192
Electrocardiogram ST segment elevation 15.14 9.73 18 497147 8379 79238844
Blood creatinine increased 15.12 9.73 801 496364 154256 79092967
X-ray abnormal 15.07 9.73 74 497091 5739 79241484
Biliary cirrhosis 15.07 9.73 11 497154 172 79247051
Feeling hot 15.01 9.73 483 496682 59251 79187972
Nephrogenic systemic fibrosis 14.95 9.73 10 497155 6150 79241073
Blood pressure systolic decreased 14.90 9.73 29 497136 11047 79236176
Temperature regulation disorder 14.89 9.73 9 497156 5844 79241379
Feeding disorder 14.88 9.73 161 497004 16093 79231130
Psychomotor skills impaired 14.87 9.73 7 497158 5230 79241993
Ventricular arrhythmia 14.84 9.73 20 497145 8820 79238403
High turnover osteopathy 14.83 9.73 7 497158 45 79247178
Oesophageal discomfort 14.76 9.73 14 497151 320 79246903
Product dose omission in error 14.72 9.73 91 497074 7697 79239526
Blood urine present 14.71 9.73 200 496965 21097 79226126
Hepatitis B reactivation 14.71 9.73 10 497155 6098 79241125
Bed bug infestation 14.67 9.73 5 497160 11 79247212
Depressed mood 14.63 9.73 401 496764 48079 79199144
Virologic failure 14.62 9.73 4 497161 4187 79243036
Hereditary angioedema 14.61 9.73 69 497096 5266 79241957
Laboratory test abnormal 14.59 9.73 251 496914 27797 79219426
Increased appetite 14.59 9.73 126 497039 11852 79235371
Gallbladder operation 14.58 9.73 36 497129 1969 79245254
Disseminated tuberculosis 14.58 9.73 4 497161 4179 79243044
Cardiac tamponade 14.57 9.73 22 497143 9254 79237969
Alveolitis 14.56 9.73 4 497161 4176 79243047
COVID-19 immunisation 14.56 9.73 29 497136 1370 79245853
Brain herniation 14.55 9.73 15 497150 7448 79239775
Infusion site bruising 14.54 9.73 46 497119 2906 79244317
Aortic dissection 14.54 9.73 4 497161 4171 79243052
Blood cholesterol abnormal 14.54 9.73 50 497115 3300 79243923
Bronchial haemorrhage 14.52 9.73 28 497137 1292 79245931
Kidney transplant rejection 14.51 9.73 26 497139 10220 79237003
Hip arthroplasty 14.50 9.73 308 496857 35448 79211775
Blood creatinine abnormal 14.46 9.73 64 497101 4753 79242470
Bronchopulmonary aspergillosis allergic 14.45 9.73 47 497118 3014 79244209
Neutralising antibodies positive 14.42 9.73 13 497152 278 79246945
Congenital coronary artery malformation 14.42 9.73 9 497156 107 79247116
Nerve degeneration 14.42 9.73 13 497152 278 79246945
Concussion 14.34 9.73 105 497060 9398 79237825
Duodenal ulcer 14.33 9.73 53 497112 16316 79230907
Infusion site pruritus 14.14 9.73 57 497108 4061 79243162
Vitamin D abnormal 14.11 9.73 10 497155 149 79247074
Hyperammonaemia 14.10 9.73 30 497135 11063 79236160
Gingival recession 14.09 9.73 27 497138 1240 79245983
Suicidal ideation 14.08 9.73 365 496800 75975 79171248
Nasal ulcer 14.08 9.73 37 497128 2103 79245120
Vestibular migraine 14.05 9.73 10 497155 150 79247073
Pseudomembranous colitis 14.05 9.73 8 497157 5366 79241857
Rotator cuff syndrome 14.03 9.73 142 497023 13953 79233270
Antipsychotic drug level increased 14.02 9.73 10 497155 5947 79241276
Cross sensitivity reaction 14.01 9.73 3 497162 3709 79243514
Cytomegalovirus test positive 13.97 9.73 10 497155 5937 79241286
Nonspecific reaction 13.92 9.73 41 497124 2491 79244732
Hepatitis B 13.84 9.73 19 497146 8313 79238910
Dust allergy 13.83 9.73 30 497135 1506 79245717
Enzyme level decreased 13.83 9.73 5 497160 14 79247209
Gastric ulcer 13.70 9.73 140 497025 33765 79213458
Amylase increased 13.69 9.73 31 497134 11178 79236045
Osteosclerosis 13.66 9.73 55 497110 3916 79243307
Mucous stools 13.59 9.73 66 497099 5096 79242127
Underdose 13.59 9.73 286 496879 32865 79214358
Eyelid margin crusting 13.58 9.73 24 497141 1035 79246188
Limb injury 13.52 9.73 259 496906 29269 79217954
Methaemoglobinaemia 13.51 9.73 9 497156 5548 79241675
Product administration error 13.50 9.73 130 497035 31716 79215507
Skin warm 13.50 9.73 79 497086 6553 79240670
Duodenitis 13.40 9.73 18 497147 7949 79239274
Ileal stenosis 13.35 9.73 39 497126 2359 79244864
Prothrombin time prolonged 13.34 9.73 57 497108 16842 79230381
Staphylococcal sepsis 13.34 9.73 47 497118 14679 79232544
Hair colour changes 13.29 9.73 57 497108 4175 79243048
Hypoalbuminaemia 13.29 9.73 78 497087 21219 79226004
Cardiomyopathy 13.26 9.73 115 497050 28659 79218564
Central obesity 13.21 9.73 32 497133 1729 79245494
Atypical fracture 13.19 9.73 19 497146 687 79246536
Stupor 13.19 9.73 14 497151 6858 79240365
Needle issue 13.17 9.73 132 497033 12936 79234287
Faeces soft 13.16 9.73 93 497072 8230 79238993
Nasal discharge discolouration 13.08 9.73 40 497125 2481 79244742
Emotional distress 13.06 9.73 173 496992 39796 79207427
Cardiovascular somatic symptom disorder 13.05 9.73 6 497159 36 79247187
Joint lock 13.02 9.73 47 497118 3178 79244045
Band sensation 12.99 9.73 20 497145 768 79246455
Blood pressure fluctuation 12.97 9.73 527 496638 66618 79180605
Lung hernia 12.96 9.73 7 497158 62 79247161
Eosinophil percentage increased 12.94 9.73 29 497136 1489 79245734
Gastrointestinal inflammation 12.94 9.73 86 497079 7458 79239765
Incorrect dose administered 12.92 9.73 593 496572 76037 79171186
Allergic sinusitis 12.91 9.73 21 497144 846 79246377
Sensitive skin 12.91 9.73 32 497133 1755 79245468
Intervertebral disc protrusion 12.88 9.73 213 496952 23408 79223815
Endodontic procedure 12.84 9.73 42 497123 2701 79244522
Cryptococcosis 12.83 9.73 3 497162 3490 79243733
Intracranial pressure increased 12.82 9.73 20 497145 8302 79238921
Hypoxic-ischaemic encephalopathy 12.82 9.73 18 497147 7802 79239421
Periarthritis 12.79 9.73 44 497121 2904 79244319
Pericardial haemorrhage 12.78 9.73 6 497159 4489 79242734
Renal artery stenosis 12.77 9.73 3 497162 3479 79243744
Vaginal haematoma 12.76 9.73 9 497156 133 79247090
Anti-cyclic citrullinated peptide antibody 12.76 9.73 71 497094 5781 79241442
Small intestinal obstruction 12.76 9.73 240 496925 27032 79220191
Meniscus injury 12.74 9.73 79 497086 6689 79240534
Ear disorder 12.71 9.73 54 497111 3939 79243284
Heart rate decreased 12.70 9.73 548 496617 69768 79177455
Immune-mediated myositis 12.69 9.73 3 497162 3464 79243759
Joint ankylosis 12.66 9.73 36 497129 2144 79245079
Expanded disability status scale score increased 12.66 9.73 18 497147 643 79246580
Right ventricular failure 12.65 9.73 90 497075 23407 79223816
Bradyarrhythmia 12.64 9.73 5 497160 4141 79243082
C-reactive protein 12.64 9.73 63 497102 4916 79242307
Uterine leiomyoma 12.63 9.73 76 497089 6367 79240856
Hypocalcaemia 12.63 9.73 404 496761 49520 79197703
Inflammatory bowel disease 12.61 9.73 69 497096 5582 79241641
Vaginal infection 12.59 9.73 71 497094 5809 79241414
Inhibitory drug interaction 12.57 9.73 6 497159 4447 79242776
Eating disorder 12.56 9.73 190 496975 20507 79226716
Anhedonia 12.55 9.73 49 497116 14849 79232374
Emotional disorder 12.48 9.73 141 497024 14246 79232977
Sputum culture positive 12.48 9.73 4 497161 3777 79243446
Nystagmus 12.41 9.73 27 497138 9877 79237346
Parathyroid tumour benign 12.41 9.73 20 497145 799 79246424
Pericardial effusion 12.39 9.73 208 496957 46029 79201194
Eructation 12.39 9.73 113 497052 10796 79236427
Chronic sinusitis 12.38 9.73 130 497035 12896 79234327
Eye disorder 12.36 9.73 210 496955 23202 79224021
Injection site induration 12.34 9.73 104 497061 9715 79237508
Post procedural hypothyroidism 12.31 9.73 9 497156 141 79247082
Breast pain 12.28 9.73 91 497074 8174 79239049
Head banging 12.28 9.73 16 497149 525 79246698
Lupus hepatitis 12.25 9.73 3 497162 0 79247223
Sinuplasty 12.25 9.73 3 497162 0 79247223
Radical mastectomy 12.25 9.73 3 497162 0 79247223
Eye pain 12.25 9.73 314 496851 37264 79209959
Duodenal ulcer haemorrhage 12.24 9.73 16 497149 7147 79240076
Hyperaesthesia teeth 12.23 9.73 32 497133 1814 79245409
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.21 9.73 4 497161 3725 79243498
Hyperprolactinaemia 12.17 9.73 7 497158 4669 79242554
Mole excision 12.15 9.73 9 497156 144 79247079
Colonoscopy 12.14 9.73 33 497132 1914 79245309
Graft versus host disease in gastrointestinal tract 12.14 9.73 13 497152 6343 79240880
Anal fissure 12.13 9.73 86 497079 7617 79239606
Feeling jittery 12.13 9.73 128 497037 12713 79234510
Intestinal stenosis 12.13 9.73 51 497114 3703 79243520
Product use issue 12.13 9.73 1490 495675 208332 79038891
Creatinine renal clearance increased 12.11 9.73 21 497144 892 79246331
Cardioactive drug level increased 12.11 9.73 4 497161 3705 79243518
Choking 12.08 9.73 122 497043 11979 79235244
Post procedural stroke 12.08 9.73 8 497157 106 79247117
Proctitis 12.06 9.73 75 497090 6357 79240866
Skin sensitisation 12.06 9.73 22 497143 973 79246250
Gingival operation 11.99 9.73 7 497158 73 79247150
Clonus 11.97 9.73 15 497150 6825 79240398
Hypogammaglobulinaemia 11.96 9.73 41 497124 12910 79234313
Behaviour disorder 11.96 9.73 13 497152 6300 79240923
Blood pressure systolic abnormal 11.95 9.73 61 497104 17186 79230037
Red blood cell count increased 11.95 9.73 55 497110 4153 79243070
Lipodystrophy acquired 11.95 9.73 6 497159 4319 79242904
Inadequate analgesia 11.94 9.73 7 497158 4622 79242601
Mass excision 11.93 9.73 13 497152 352 79246871
Dermatitis acneiform 11.91 9.73 28 497137 9965 79237258
Ventricular dysfunction 11.86 9.73 12 497153 6011 79241212
Ventricular extrasystoles 11.85 9.73 73 497092 19631 79227592
Eyelid disorder 11.82 9.73 33 497132 1945 79245278
Hyperparathyroidism secondary 11.80 9.73 40 497125 2620 79244603
Therapeutic response shortened 11.80 9.73 151 497014 15712 79231511
Hypophosphataemia 11.77 9.73 182 496983 19731 79227492
Dysarthria 11.77 9.73 326 496839 67296 79179927
Pulmonary congestion 11.75 9.73 110 497055 26990 79220233
Kounis syndrome 11.74 9.73 6 497159 4276 79242947
Groin pain 11.71 9.73 129 497036 12951 79234272
Alcohol interaction 11.71 9.73 8 497157 4866 79242357
Vasoplegia syndrome 11.70 9.73 4 497161 3626 79243597
Inability to afford medication 11.69 9.73 41 497124 2732 79244491
Fungal infection 11.67 9.73 342 496823 41406 79205817
Laryngitis 11.65 9.73 152 497013 15887 79231336
Open reduction of fracture 11.65 9.73 11 497154 250 79246973
Sickle cell anaemia with crisis 11.65 9.73 87 497078 7835 79239388
Intestinal obstruction 11.64 9.73 351 496814 42669 79204554
Sciatic nerve injury 11.61 9.73 16 497149 555 79246668
Ileostomy 11.59 9.73 30 497135 1690 79245533
Monoparesis 11.58 9.73 48 497117 3463 79243760
Long QT syndrome 11.57 9.73 12 497153 5943 79241280
Drug delivery device placement 11.56 9.73 10 497155 202 79247021
Congestive hepatopathy 11.56 9.73 7 497158 4540 79242683
Bronchial disorder 11.55 9.73 38 497127 2451 79244772
Nasal oedema 11.54 9.73 30 497135 1694 79245529
Apnoea 11.54 9.73 36 497129 11668 79235555
Respiratory tract malformation 11.53 9.73 8 497157 115 79247108
Tumour marker increased 11.52 9.73 55 497110 4217 79243006
Alcohol use 11.51 9.73 8 497157 4823 79242400
Obstructive airways disorder 11.50 9.73 267 496898 31192 79216031
Lymph node pain 11.45 9.73 28 497137 1522 79245701
Pancreatitis necrotising 11.45 9.73 5 497160 3903 79243320
Dairy intolerance 11.45 9.73 7 497158 80 79247143
Abdominoplasty 11.45 9.73 7 497158 80 79247143
Abnormal behaviour 11.41 9.73 159 497006 36262 79210961
Breast cancer stage I 11.41 9.73 15 497150 6685 79240538
Herpes zoster 11.40 9.73 699 496466 92384 79154839
Weight bearing difficulty 11.39 9.73 45 497120 3176 79244047
Pneumonia pseudomonal 11.39 9.73 12 497153 5899 79241324
Pseudomonal sepsis 11.38 9.73 13 497152 6161 79241062
Ischaemic cardiomyopathy 11.38 9.73 19 497146 7676 79239547
Compartment syndrome 11.36 9.73 9 497156 5073 79242150
Bacterial vaginosis 11.35 9.73 24 497141 1184 79246039
Intestinal resection 11.34 9.73 50 497115 3707 79243516
Endocrine ophthalmopathy 11.34 9.73 18 497147 710 79246513
Pancreatitis 11.33 9.73 333 496832 68242 79178981
Hypertriglyceridaemia 11.32 9.73 41 497124 12699 79234524
Generalised oedema 11.27 9.73 94 497071 23615 79223608
Hyperreflexia 11.24 9.73 22 497143 8363 79238860
Spinal pain 11.23 9.73 146 497019 15246 79231977
Nervous system disorder 11.23 9.73 110 497055 26746 79220477
Immune thrombocytopenia 11.22 9.73 65 497100 17740 79229483
Candida infection 11.22 9.73 169 496996 38045 79209178
Immunoglobulins increased 11.19 9.73 17 497148 645 79246578
Antineutrophil cytoplasmic antibody positive 11.19 9.73 25 497140 1281 79245942
Lower respiratory tract infection viral 11.19 9.73 24 497141 1196 79246027
Vaccination site reaction 11.18 9.73 8 497157 121 79247102
Laryngeal oedema 11.18 9.73 21 497144 8108 79239115
Premature delivery 11.17 9.73 93 497072 23374 79223849
Leukocytosis 11.16 9.73 197 496968 43258 79203965
Exostosis 11.11 9.73 157 497008 16701 79230522
Localised infection 11.11 9.73 310 496855 37265 79209958
Thyroxine free increased 11.03 9.73 24 497141 1208 79246015
Decreased immune responsiveness 11.00 9.73 65 497100 5410 79241813
Metastases to liver 11 9.73 118 497047 28196 79219027
Prostatic specific antigen increased 11.00 9.73 106 497059 10280 79236943
Neutrophil percentage increased 10.97 9.73 58 497107 4631 79242592
Second primary malignancy 10.97 9.73 49 497116 14301 79232922
Root canal infection 10.93 9.73 13 497152 388 79246835
Specific gravity urine increased 10.92 9.73 14 497151 452 79246771
Urinary retention 10.92 9.73 269 496896 56361 79190862
Drug specific antibody present 10.91 9.73 75 497090 6577 79240646
Oncologic complication 10.89 9.73 12 497153 329 79246894
Ligament rupture 10.88 9.73 46 497119 3348 79243875
Foetal death 10.87 9.73 21 497144 8023 79239200
C-reactive protein decreased 10.87 9.73 39 497126 2629 79244594
Type I hypersensitivity 10.86 9.73 7 497158 4391 79242832
Feeling cold 10.86 9.73 245 496920 28484 79218739
Therapy interrupted 10.84 9.73 264 496901 31077 79216146
Vasculitis 10.84 9.73 102 497063 25000 79222223
Pyelitis 10.84 9.73 12 497153 331 79246892
Ear discomfort 10.83 9.73 91 497074 8492 79238731
Premature baby 10.82 9.73 5 497160 3775 79243448
Cardiopulmonary failure 10.81 9.73 16 497149 6785 79240438
Neutrophil count decreased 10.80 9.73 477 496688 93482 79153741
Breast disorder 10.78 9.73 33 497132 2048 79245175
Apathy 10.73 9.73 43 497122 12934 79234289
Brain abscess 10.71 9.73 9 497156 4927 79242296
Endometrial hypertrophy 10.69 9.73 9 497156 175 79247048
Pneumonia fungal 10.69 9.73 35 497130 11175 79236048
Left ventricular hypertrophy 10.63 9.73 35 497130 11156 79236067
Stridor 10.59 9.73 11 497154 5442 79241781
Acute graft versus host disease in intestine 10.59 9.73 6 497159 4035 79243188
Organising pneumonia 10.53 9.73 34 497131 10905 79236318
Fear 10.52 9.73 87 497078 21899 79225324
Prostate cancer 10.51 9.73 145 497020 33123 79214100
Carcinoembryonic antigen increased 10.50 9.73 34 497131 2175 79245048
Lymphadenitis 10.50 9.73 57 497108 4598 79242625
Lacunar infarction 10.49 9.73 13 497152 5944 79241279
Right ventricular hypertrophy 10.47 9.73 28 497137 1609 79245614
Hyperuricaemia 10.46 9.73 38 497127 11761 79235462
Gingival discolouration 10.46 9.73 10 497155 231 79246992
Lupus vulgaris 10.46 9.73 45 497120 3301 79243922
Crepitations 10.46 9.73 30 497135 9987 79237236
Coeliac disease 10.44 9.73 36 497129 11315 79235908
Jaw disorder 10.43 9.73 60 497105 4946 79242277
Shoulder deformity 10.43 9.73 7 497158 95 79247128
Magnetic resonance imaging abnormal 10.41 9.73 46 497119 3413 79243810
Prerenal failure 10.41 9.73 5 497160 3693 79243530
Blood albumin abnormal 10.41 9.73 17 497148 687 79246536
Injection site joint pain 10.41 9.73 4 497161 14 79247209
Paradoxical drug reaction 10.39 9.73 18 497147 7167 79240056
Intestinal mass 10.37 9.73 24 497141 1259 79245964
Hypophosphataemic osteomalacia 10.36 9.73 12 497153 348 79246875
Chronic left ventricular failure 10.36 9.73 21 497144 1005 79246218
Venoocclusive disease 10.34 9.73 8 497157 4565 79242658
Invasive lobular breast carcinoma 10.28 9.73 17 497148 694 79246529
Decreased interest 10.26 9.73 48 497117 3649 79243574
Temperature intolerance 10.25 9.73 99 497066 9606 79237617
Spinal cord injury lumbar 10.24 9.73 6 497159 63 79247160
Gastric volvulus 10.20 9.73 4 497161 15 79247208
Thyroxine decreased 10.20 9.73 19 497146 854 79246369
Catheterisation venous 10.19 9.73 3 497162 3 79247220
Nail bed infection bacterial 10.19 9.73 3 497162 3 79247220
Medical device battery replacement 10.19 9.73 3 497162 3 79247220
Haemorrhage 10.19 9.73 464 496701 90654 79156569
Gingival pain 10.11 9.73 93 497072 8905 79238318
Initial insomnia 10.09 9.73 76 497089 6862 79240361
Unintended pregnancy 10.07 9.73 6 497159 3927 79243296
Hair disorder 10.07 9.73 22 497143 1110 79246113
Faeces hard 10.07 9.73 40 497125 2831 79244392
Pleural fibrosis 10.07 9.73 52 497113 4115 79243108
Eustachian tube obstruction 10.06 9.73 7 497158 101 79247122
Seborrhoeic keratosis 10.04 9.73 35 497130 2325 79244898
Skin injury 10.03 9.73 45 497120 3361 79243862
Nerve injury 10.02 9.73 96 497069 9296 79237927
Bone hypertrophy 10.02 9.73 15 497150 562 79246661
Azotaemia 10.01 9.73 23 497142 8253 79238970
Polyneuropathy idiopathic progressive 10.00 9.73 4 497161 16 79247207
Nightmare 9.96 9.73 108 497057 25753 79221470
Diffuse alveolar damage 9.96 9.73 5 497160 3599 79243624
Dyskinesia 9.96 9.73 208 496957 44565 79202658
Pruritus genital 9.96 9.73 8 497157 4478 79242745
Hepatic cancer 9.95 9.73 33 497132 10496 79236727
Ligament sprain 9.95 9.73 128 497037 13336 79233887
Infusion site mass 9.94 9.73 27 497138 1566 79245657
Medial tibial stress syndrome 9.92 9.73 8 497157 146 79247077
N-terminal prohormone brain natriuretic peptide increased 9.92 9.73 9 497156 4746 79242477
Regurgitation 9.91 9.73 39 497126 2748 79244475
Cyclic vomiting syndrome 9.89 9.73 7 497158 104 79247119
Cystic fibrosis respiratory infection suppression 9.88 9.73 13 497152 431 79246792
Bladder hypertrophy 9.86 9.73 16 497149 643 79246580
Muscle haemorrhage 9.84 9.73 15 497150 6285 79240938
Osteoporosis postmenopausal 9.81 9.73 4 497161 17 79247206
C-telopeptide increased 9.81 9.73 4 497161 17 79247206
Toe operation 9.80 9.73 15 497150 573 79246650
Stoma complication 9.79 9.73 18 497147 801 79246422
Primary progressive multiple sclerosis 9.78 9.73 7 497158 106 79247117
Infusion site erythema 9.75 9.73 96 497069 9364 79237859
Hordeolum 9.74 9.73 43 497122 3190 79244033
Colporrhaphy 9.74 9.73 3 497162 4 79247219
Skin burning sensation 9.73 9.73 126 497039 13146 79234077

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
FDA CS M0007651 Ergocalciferols
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175909 Provitamin D2 Compound
CHEBI has role CHEBI:33288 rodenticides
CHEBI has role CHEBI:50646 antiosteoporotic
CHEBI has role CHEBI:50733 Dietary Supplement
CHEBI has role CHEBI:76924 plant metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Familial x-linked hypophosphatemic vitamin D refractory rickets indication 82236004
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Vitamin Deficiency Prevention indication
Hyperparathyroidism Secondary to Chronic Renal Failure with Dialysis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Glucocorticoid Induced Osteoporosis indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Hyperparathyroidism Secondary to Chronic Renal Failure off-label use
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK

External reference:

IDSource
4017629 VUID
N0000146009 NUI
D00187 KEGG_DRUG
4017629 VANDF
4017649 VANDF
4021908 VANDF
C0014695 UMLSCUI
CHEBI:28934 CHEBI
D2V PDB_CHEM_ID
CHEMBL1536 ChEMBL_ID
DB00153 DRUGBANK_ID
5280793 PUBCHEM_CID
382 INN_ID
VS041H42XC UNII
DB11094 DRUGBANK_ID
11253 RXNORM
1067 MMSL
315714 MMSL
335232 MMSL
3554 MMSL
4671 MMSL
5688 MMSL
6150 MMSL
d03128 MMSL
001013 NDDF
11563006 SNOMEDCT_US
23433006 SNOMEDCT_US
30178006 SNOMEDCT_US
71516007 SNOMEDCT_US
D004872 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 10544-527 CAPSULE 1.25 mg ORAL ANDA 19 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 23155-809 CAPSULE 1.25 mg ORAL ANDA 16 sections
DRISDOL HUMAN PRESCRIPTION DRUG LABEL 1 30698-493 CAPSULE, LIQUID FILLED 1.25 mg ORAL NDA 19 sections
DRISDOL HUMAN PRESCRIPTION DRUG LABEL 1 30698-493 CAPSULE, LIQUID FILLED 1.25 mg ORAL NDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 33261-730 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 42291-266 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 20 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 42794-006 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 19 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 42806-547 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43063-711 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43353-219 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 43353-238 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 20 sections
VITAMIN D Human Prescription Drug Label 1 43353-828 CAPSULE 1.25 mg ORAL ANDA 19 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 50090-3201 CAPSULE 1.25 1 ORAL ANDA 15 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4382 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-4382 CAPSULE, LIQUID FILLED 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-5844 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 50090-5844 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 50268-297 CAPSULE 1.25 mg ORAL ANDA 15 sections
ERGOCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 51407-143 CAPSULE 1.25 mg ORAL ANDA 18 sections
ERGOCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 51407-143 CAPSULE 1.25 mg ORAL ANDA 18 sections
ERGOCALCIFEROL HUMAN PRESCRIPTION DRUG LABEL 1 51407-143 CAPSULE 1.25 mg ORAL ANDA 18 sections
Ergocalciferol Capsules, HUMAN PRESCRIPTION DRUG LABEL 1 51655-730 CAPSULE 1.25 mg ORAL ANDA 18 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 51655-774 CAPSULE 1.25 mg ORAL ANDA 15 sections
VITAMIN D HUMAN PRESCRIPTION DRUG LABEL 1 53217-287 CAPSULE 1.25 mg ORAL ANDA 16 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 54868-5799 CAPSULE 1.25 mg ORAL ANDA 11 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 60687-500 CAPSULE 1.25 mg ORAL ANDA 19 sections
Ergocalciferol HUMAN PRESCRIPTION DRUG LABEL 1 60687-500 CAPSULE 1.25 mg ORAL ANDA 19 sections