riboflavin Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
2834 83-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavine
  • beflavine
  • lactoflavin
  • lactoflavine
  • Vitamin B2
  • riboflavin (vit B2)
  • riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
  • Molecular weight: 376.37
  • Formula: C17H20N4O6
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 155.05
  • ALOGS: -2.76
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA04 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D003879 Dermatologic Agents
MeSH PA D006133 Growth Substances
MeSH PA D018977 Micronutrients
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:47868 photosensitizing agent
CHEBI has role CHEBI:77182 food colouring
CHEBI has role CHEBI:75769 B vitamin

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Glutaric aciduria, type 2 off-label use 22886006 DOID:0060358
Glutaric aciduria, type 1 off-label use 76175005
Migraine Prevention off-label use
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005 DOID:8677
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000 DOID:13580
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:2527
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002 DOID:1826
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.13 acidic
pKa2 11.89 acidic
pKa3 13.48 acidic
pKa4 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Riboflavin kinase Kinase WOMBAT-PK
Flavin reductase (NADPH) Enzyme WOMBAT-PK
Riboflavin-binding protein Unclassified Kd 8.30 CHEMBL

External reference:

IDSource
DB00140 DRUGBANK_ID
4017778 VUID
N0000146139 NUI
C0035527 UMLSCUI
D00050 KEGG_DRUG
4017633 VANDF
4017778 VANDF
329260009 SNOMEDCT_US
5062 MMSL
9346 RXNORM
13235001 SNOMEDCT_US
5422 MMSL
d00409 MMSL
5060 MMSL
5683 MMSL
N0000146013 NDFRT
N0000005897 NDFRT
N0000146139 NDFRT
001059 NDDF
CHEMBL1534 ChEMBL_ID
493570 PUBCHEM_CID
CHEMBL1397833 ChEMBL_ID
D012256 MESH_DESCRIPTOR_UI
TLM2976OFR UNII
419 INN_ID
CHEBI:17015 CHEBI
RBF PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PreferaOB plus DHA HUMAN PRESCRIPTION DRUG LABEL 12 0037-0083 KIT 1.60 mg ORAL Unapproved drug other 13 sections
PreferaOB HUMAN PRESCRIPTION DRUG LABEL 12 0037-0084 TABLET, COATED 1.60 mg ORAL Unapproved drug other 12 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 13 0178-0821 TABLET 3.40 mg ORAL Unapproved drug other 10 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 11 0178-0858 TABLET 3.40 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 12 0178-0859 TABLET 3.40 mg ORAL Unapproved drug other 8 sections
CitraNatal Assure HUMAN PRESCRIPTION DRUG LABEL 13 0178-0891 KIT 3.40 mg None unapproved drug other 12 sections
CitraNatal Assure HUMAN PRESCRIPTION DRUG LABEL 14 0178-0893 KIT 3.40 mg None Unapproved drug other 12 sections
CitraNatal DHA HUMAN PRESCRIPTION DRUG LABEL 14 0178-0894 KIT 3.40 mg None unapproved drug other 11 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 12 0178-0898 TABLET 3.40 mg ORAL Unapproved drug other 10 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 11 0642-0070 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 6 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 9 0642-0072 CAPSULE 1.80 mg ORAL UNAPPROVED DRUG OTHER 9 sections
Select-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 14 0642-0075 KIT 1.80 mg None Unapproved drug other 7 sections
Vitafol-OB Plus DHA HUMAN PRESCRIPTION DRUG LABEL 10 0642-0076 KIT 1.80 mg None Unapproved drug other 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 11 0642-0077 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Vitafol OB HUMAN PRESCRIPTION DRUG LABEL 9 0642-0079 TABLET 1.80 mg ORAL Unapproved drug other 11 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 12 0642-0092 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 15 0642-0093 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 12 0642-0096 KIT 1.80 mg None UNAPPROVED DRUG OTHER 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 13 0642-0120 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Strovite Forte HUMAN PRESCRIPTION DRUG LABEL 11 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Strovite One HUMAN PRESCRIPTION DRUG LABEL 16 0642-0207 TABLET 5 mg ORAL UNAPPROVED DRUG OTHER 10 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 11 0642-3010 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 6 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 11 0682-1570 CAPSULE 3.40 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 15 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 9 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 12 0813-0202 TABLET 1.60 mg ORAL UNAPPROVED DRUG OTHER 6 sections
O-Cal FA multivitamin HUMAN PRESCRIPTION DRUG LABEL 13 0813-9616 TABLET 3 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 10 10542-009 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 8 10542-010 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 9 10542-011 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections