riboflavin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	2834	83-88-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: riboflavine beflavine lactoflavin lactoflavine Vitamin B2 riboflavin (vit B2) riboflavin	Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE. Molecular weight: 376.37 Formula: C17H20N4O6 CLOGP: -0.73 LIPINSKI: 0 HAC: 10 HDO: 5 TPSA: 155.05 ALOGS: -2.76 ROTB: 5 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

riboflavine
beflavine
lactoflavin
lactoflavine
Vitamin B2
riboflavin (vit B2)
riboflavin

Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.

Molecular weight: 376.37
Formula: C17H20N4O6
CLOGP: -0.73
LIPINSKI: 0
HAC: 10
HDO: 5
TPSA: 155.05
ALOGS: -2.76
ROTB: 5

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
EoM (Fraction excreted unchanged in urine)	75 %	Benet LZ, Broccatelli F, Oprea TI
BDDCS (Biopharmaceutical Drug Disposition Classification System)	4	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	1.33 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
S (Water solubility)	0.09 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
Feb. 20, 1953	FDA	HOSPIRA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pemphigus	1777.11	10.31	4404	526666	179322	62778630
Systemic lupus erythematosus	1676.98	10.31	4671	526399	204247	62753705
Glossodynia	1484.22	10.31	4049	527021	174827	62783125
Hand deformity	1209.92	10.31	3495	527575	155962	62801990
Arthropathy	1122.03	10.31	4404	526666	230388	62727564
Abdominal discomfort	1042.12	10.31	5366	525704	315519	62642433
Alopecia	1032.13	10.31	5551	525519	331985	62625967
Wound	1002.99	10.31	3325	527745	159938	62798014
Completed suicide	958.42	10.31	67	531003	145606	62812346
Rheumatoid arthritis	892.96	10.31	4343	526727	249476	62708476

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	550.92	10.27	830	182399	37408	34736294
Drug abuse	377.49	10.27	40	183189	99056	34674646
Toxicity to various agents	303.94	10.27	362	182867	200000	34573702
Completed suicide	277.00	10.27	85	183144	98083	34675619
Foetal exposure during pregnancy	266.83	10.27	606	182623	37495	34736207
Arthralgia	230.59	10.27	1603	181626	168438	34605264
Psoriatic arthropathy	194.25	10.27	362	182867	19436	34754266
Drug interaction	185.58	10.27	588	182641	225358	34548344
Sickle cell anaemia with crisis	141.50	10.27	138	183091	3915	34769787
Joint swelling	138.79	10.27	652	182577	59238	34714464

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Rheumatoid arthritis	1219.58	9.99	3649	539514	204821	78996404
Completed suicide	1169.13	9.99	148	543015	245619	78955606
Toxicity to various agents	1019.99	9.99	826	542337	420714	78780511
Arthropathy	968.08	9.99	3028	540135	174083	79027142
Pemphigus	946.63	9.99	2094	541069	97488	79103737
Systemic lupus erythematosus	943.06	9.99	2356	540807	118793	79082432
Joint swelling	928.37	9.99	4160	539003	284486	78916739
Hand deformity	918.55	9.99	2123	541040	101796	79099429
Synovitis	890.95	9.99	2649	540514	148085	79053140
Glossodynia	825.68	9.99	2030	541133	101307	79099918

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	A11HA04	ALIMENTARY TRACT AND METABOLISM VITAMINS OTHER PLAIN VITAMIN PREPARATIONS Other plain vitamin preparations
ATC	S01XA26	SENSORY ORGANS OPHTHALMOLOGICALS OTHER OPHTHALMOLOGICALS Other ophthalmologicals
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:47868	photosensitising agent
CHEBI has role	CHEBI:67079	anti-inflammatory agents
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:76971	Escherichia coli metabolites
CHEBI has role	CHEBI:77182	food coloring

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Vitamin deficiency	indication	85670002
Mineral deficiency	indication	111379007
Vitamin Deficiency Prevention	indication
Mineral Deficiency Prevention	indication
Glutaric aciduria, type 2	off-label use	22886006	DOID:0060358
Glutaric aciduria, type 1	off-label use	76175005
Migraine Prevention	off-label use
Necrotizing enterocolitis in fetus OR newborn	contraindication	2707005
Alcoholism	contraindication	7200002
Peptic ulcer	contraindication	13200003	DOID:750

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.13	acidic
pKa2	11.89	acidic
pKa3	13.48	acidic
pKa4	2.49	Basic

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Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Flavin reductase (NADPH)	Enzyme	P30043	BLVRB_HUMAN			WOMBAT-PK
Riboflavin kinase	Kinase	Q969G6	RIFK_HUMAN			WOMBAT-PK
Riboflavin-binding protein	Unclassified		RBP_CHICK	Kd	8.30	CHEMBL

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External reference:

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ID	Source
RBF	PDB_CHEM_ID
001059	NDDF
13235001	SNOMEDCT_US
329260009	SNOMEDCT_US
4017633	VANDF
4017778	VUID
4017778	VANDF
4021901	VANDF
419	INN_ID
493570	PUBCHEM_CID

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
BACMIN	HUMAN PRESCRIPTION DRUG LABEL	19	0682-3001	TABLET, COATED	20 mg	ORAL	UNAPPROVED DRUG OTHER	10 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	3.40 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	3.40 mg	ORAL	unapproved drug other	11 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	3.40 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	3.40 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	3.40 mg	ORAL	Unapproved drug other	9 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	1.70 mg	ORAL	Unapproved drug other	7 sections
Dialyvite	HUMAN PRESCRIPTION DRUG LABEL	9	10542-010	TABLET, COATED	1.70 mg	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	1.70 mg	ORAL	Unapproved drug other	7 sections
Dialyvite 5000	HUMAN PRESCRIPTION DRUG LABEL	12	10542-011	TABLET, COATED	1.70 mg	ORAL	Unapproved drug other	7 sections

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