Stem definition | Drug id | CAS RN |
---|---|---|
2832 | 59-43-8 |
Dose | Unit | Route |
---|---|---|
50 | mg | O |
50 | mg | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 500 mg/mL | Bocci G, Oprea TI, Benet LZ |
EoM (Fraction excreted unchanged in urine) | 90 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 5.55 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 4.50 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 29, 1993 | FDA | HOSPIRA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Pemphigus | 1726.75 | 10.32 | 4403 | 535873 | 179323 | 62769423 |
Systemic lupus erythematosus | 1626.69 | 10.32 | 4671 | 535605 | 204247 | 62744499 |
Glossodynia | 1439.36 | 10.32 | 4048 | 536228 | 174828 | 62773918 |
Hand deformity | 1172.81 | 10.32 | 3495 | 536781 | 155962 | 62792784 |
Arthropathy | 1089.69 | 10.32 | 4416 | 535860 | 230376 | 62718370 |
Abdominal discomfort | 1010.41 | 10.32 | 5387 | 534889 | 315498 | 62633248 |
Alopecia | 1001.29 | 10.32 | 5575 | 534701 | 331961 | 62616785 |
Wound | 971.12 | 10.32 | 3327 | 536949 | 159936 | 62788810 |
Completed suicide | 941.64 | 10.32 | 80 | 540196 | 145593 | 62803153 |
Maternal exposure during pregnancy | 866.53 | 10.32 | 3939 | 536337 | 216123 | 62732623 |
Rheumatoid arthritis | 866.17 | 10.32 | 4359 | 535917 | 249460 | 62699286 |
Synovitis | 768.86 | 10.32 | 3390 | 536886 | 183528 | 62765218 |
Toxicity to various agents | 738.36 | 10.32 | 612 | 539664 | 246638 | 62702108 |
Anti-cyclic citrullinated peptide antibody positive | 733.79 | 10.32 | 2417 | 537859 | 113795 | 62834951 |
Pericarditis | 726.52 | 10.32 | 2617 | 537659 | 128962 | 62819784 |
Discomfort | 722.28 | 10.32 | 3080 | 537196 | 164294 | 62784452 |
Swelling | 719.98 | 10.32 | 4401 | 535875 | 270977 | 62677769 |
Contraindicated product administered | 689.46 | 10.32 | 3662 | 536614 | 213986 | 62734760 |
Infusion related reaction | 656.28 | 10.32 | 3947 | 536329 | 241574 | 62707172 |
Joint swelling | 650.51 | 10.32 | 4892 | 535384 | 322774 | 62625972 |
Pain | 565.23 | 10.32 | 9134 | 531142 | 731494 | 62217252 |
Death | 524.54 | 10.32 | 1546 | 538730 | 372835 | 62575911 |
Duodenal ulcer perforation | 461.22 | 10.32 | 1711 | 538565 | 85498 | 62863248 |
Rheumatoid factor positive | 452.24 | 10.32 | 1663 | 538613 | 82743 | 62866003 |
Helicobacter infection | 447.66 | 10.32 | 1768 | 538508 | 91017 | 62857729 |
Product use issue | 431.63 | 10.32 | 3283 | 536993 | 217237 | 62731509 |
Drug interaction | 399.42 | 10.32 | 845 | 539431 | 228286 | 62720460 |
Intentional overdose | 398.70 | 10.32 | 74 | 540202 | 74078 | 62874668 |
Hepatic enzyme increased | 393.55 | 10.32 | 3008 | 537268 | 199320 | 62749426 |
Drug abuse | 373.94 | 10.32 | 80 | 540196 | 72438 | 62876308 |
Arthralgia | 368.24 | 10.32 | 6846 | 533430 | 562864 | 62385882 |
Psoriatic arthropathy | 335.76 | 10.32 | 1606 | 538670 | 89914 | 62858832 |
Musculoskeletal stiffness | 331.05 | 10.32 | 2694 | 537582 | 181924 | 62766822 |
Therapeutic product effect decreased | 313.05 | 10.32 | 2756 | 537520 | 190431 | 62758315 |
Febrile neutropenia | 297.80 | 10.32 | 341 | 539935 | 118108 | 62830638 |
Drug intolerance | 295.69 | 10.32 | 3964 | 536312 | 304697 | 62644049 |
Exposure during pregnancy | 286.50 | 10.32 | 2284 | 537992 | 153263 | 62795483 |
Suicide attempt | 255.65 | 10.32 | 99 | 540177 | 60819 | 62887927 |
Treatment failure | 255.09 | 10.32 | 2703 | 537573 | 196340 | 62752406 |
Depressed level of consciousness | 245.83 | 10.32 | 110 | 540166 | 61968 | 62886778 |
Hip arthroplasty | 241.98 | 10.32 | 923 | 539353 | 46723 | 62902023 |
Knee arthroplasty | 234.53 | 10.32 | 999 | 539277 | 53207 | 62895539 |
Hypersensitivity | 222.83 | 10.32 | 3613 | 536663 | 289072 | 62659674 |
Overdose | 220.56 | 10.32 | 401 | 539875 | 114677 | 62834069 |
Malignant neoplasm progression | 217.91 | 10.32 | 226 | 540050 | 81895 | 62866851 |
Cardiac arrest | 211.06 | 10.32 | 287 | 539989 | 92258 | 62856488 |
Acute kidney injury | 205.74 | 10.32 | 1354 | 538922 | 262061 | 62686685 |
Rheumatic fever | 202.58 | 10.32 | 815 | 539461 | 42296 | 62906450 |
Disease progression | 197.96 | 10.32 | 472 | 539804 | 122286 | 62826460 |
Impaired healing | 196.01 | 10.32 | 1519 | 538757 | 101023 | 62847723 |
Nasopharyngitis | 186.90 | 10.32 | 3121 | 537155 | 251136 | 62697610 |
Neutropenia | 183.96 | 10.32 | 814 | 539462 | 174191 | 62774555 |
Constipation | 178.27 | 10.32 | 1151 | 539125 | 223792 | 62724954 |
Swollen joint count increased | 176.98 | 10.32 | 691 | 539585 | 35363 | 62913383 |
Sedation | 166.29 | 10.32 | 61 | 540215 | 38748 | 62909998 |
Blister | 162.48 | 10.32 | 1755 | 538521 | 128059 | 62820687 |
Folliculitis | 161.68 | 10.32 | 1089 | 539187 | 69228 | 62879518 |
Red blood cell sedimentation rate abnormal | 160.88 | 10.32 | 450 | 539826 | 19332 | 62929414 |
Muscle injury | 157.50 | 10.32 | 1024 | 539252 | 64321 | 62884425 |
Lactic acidosis | 152.91 | 10.32 | 67 | 540209 | 38220 | 62910526 |
Nausea | 150.21 | 10.32 | 5853 | 534423 | 848618 | 62100128 |
Fatigue | 147.97 | 10.32 | 9089 | 531187 | 878939 | 62069807 |
Bradycardia | 146.78 | 10.32 | 248 | 540028 | 72979 | 62875767 |
Cardiac failure | 141.12 | 10.32 | 346 | 539930 | 88796 | 62859950 |
Hypotension | 140.94 | 10.32 | 1561 | 538715 | 271043 | 62677703 |
Sleep disorder due to general medical condition, insomnia type | 139.40 | 10.32 | 840 | 539436 | 51377 | 62897369 |
Sickle cell anaemia with crisis | 137.97 | 10.32 | 210 | 540066 | 5793 | 62942953 |
Somnolence | 134.64 | 10.32 | 928 | 539348 | 177757 | 62770989 |
Drug hypersensitivity | 134.26 | 10.32 | 1849 | 538427 | 308838 | 62639908 |
Rash | 131.60 | 10.32 | 5931 | 534345 | 554940 | 62393806 |
Renal failure | 130.49 | 10.32 | 536 | 539740 | 117116 | 62831630 |
Irritable bowel syndrome | 128.80 | 10.32 | 1167 | 539109 | 81245 | 62867501 |
Hyponatraemia | 125.86 | 10.32 | 507 | 539769 | 111393 | 62837353 |
Respiratory arrest | 124.37 | 10.32 | 61 | 540215 | 32584 | 62916162 |
Sopor | 123.76 | 10.32 | 20 | 540256 | 22144 | 62926602 |
C-reactive protein abnormal | 123.34 | 10.32 | 742 | 539534 | 45354 | 62903392 |
Drug reaction with eosinophilia and systemic symptoms | 123.29 | 10.32 | 67 | 540209 | 33769 | 62914977 |
Electrocardiogram QT prolonged | 122.67 | 10.32 | 198 | 540078 | 59332 | 62889414 |
Rhabdomyolysis | 122.27 | 10.32 | 116 | 540160 | 43835 | 62904911 |
Neoplasm progression | 121.68 | 10.32 | 80 | 540196 | 36348 | 62912398 |
Hyperhidrosis | 121.65 | 10.32 | 488 | 539788 | 107348 | 62841398 |
Agitation | 119.19 | 10.32 | 203 | 540073 | 59554 | 62889192 |
Intentional self-injury | 117.69 | 10.32 | 36 | 540240 | 25651 | 62923095 |
Diarrhoea | 117.55 | 10.32 | 4937 | 535339 | 710429 | 62238317 |
Lower respiratory tract infection | 116.94 | 10.32 | 1676 | 538600 | 130631 | 62818115 |
Blood cholesterol increased | 116.58 | 10.32 | 1269 | 539007 | 92763 | 62855983 |
Asthenia | 115.09 | 10.32 | 2439 | 537837 | 381165 | 62567581 |
Osteoarthritis | 113.76 | 10.32 | 1277 | 538999 | 94066 | 62854680 |
Anxiety | 110.29 | 10.32 | 1251 | 539025 | 216290 | 62732456 |
Dyspnoea | 109.21 | 10.32 | 4561 | 535715 | 656752 | 62291994 |
Cardio-respiratory arrest | 107.79 | 10.32 | 217 | 540059 | 59742 | 62889004 |
Tremor | 107.57 | 10.32 | 671 | 539605 | 131568 | 62817178 |
Vomiting | 105.37 | 10.32 | 3800 | 536476 | 555817 | 62392929 |
Syncope | 103.77 | 10.32 | 580 | 539696 | 116805 | 62831941 |
Tachycardia | 103.26 | 10.32 | 586 | 539690 | 117570 | 62831176 |
Liver injury | 101.80 | 10.32 | 871 | 539405 | 59649 | 62889097 |
Condition aggravated | 100.05 | 10.32 | 4280 | 535996 | 397937 | 62550809 |
Arthritis | 98.70 | 10.32 | 1459 | 538817 | 114462 | 62834284 |
Serotonin syndrome | 98.53 | 10.32 | 61 | 540215 | 28621 | 62920125 |
Pregnancy | 97.31 | 10.32 | 591 | 539685 | 36245 | 62912501 |
Type 2 diabetes mellitus | 97.04 | 10.32 | 899 | 539377 | 62969 | 62885777 |
Psoriasis | 96.28 | 10.32 | 1148 | 539128 | 85809 | 62862937 |
Thrombocytopenia | 95.08 | 10.32 | 825 | 539451 | 150332 | 62798414 |
Cognitive disorder | 93.65 | 10.32 | 210 | 540066 | 55605 | 62893141 |
Hypoglycaemia | 90.53 | 10.32 | 239 | 540037 | 59826 | 62888920 |
Fibromyalgia | 90.49 | 10.32 | 1065 | 539211 | 79355 | 62869391 |
Anaemia | 87.82 | 10.32 | 1866 | 538410 | 291564 | 62657182 |
Intentional product misuse | 87.61 | 10.32 | 248 | 540028 | 60669 | 62888077 |
No adverse event | 86.92 | 10.32 | 136 | 540140 | 41269 | 62907477 |
Sedation complication | 85.50 | 10.32 | 9 | 540267 | 13813 | 62934933 |
Coma | 84.01 | 10.32 | 274 | 540002 | 64090 | 62884656 |
Renal impairment | 83.95 | 10.32 | 426 | 539850 | 87929 | 62860817 |
Hepatic function abnormal | 82.83 | 10.32 | 117 | 540159 | 37025 | 62911721 |
Drug resistance | 82.70 | 10.32 | 46 | 540230 | 22887 | 62925859 |
Live birth | 82.08 | 10.32 | 433 | 539843 | 25197 | 62923549 |
Orthostatic hypotension | 81.55 | 10.32 | 113 | 540163 | 36047 | 62912699 |
Macular degeneration | 80.78 | 10.32 | 54 | 540222 | 24322 | 62924424 |
Asthma | 80.31 | 10.32 | 696 | 539580 | 126865 | 62821881 |
Contusion | 79.33 | 10.32 | 1752 | 538524 | 148292 | 62800454 |
Intentional product use issue | 79.32 | 10.32 | 1529 | 538747 | 126363 | 62822383 |
Hyperglycaemia | 79.18 | 10.32 | 147 | 540129 | 41720 | 62907026 |
Drug dependence | 78.79 | 10.32 | 56 | 540220 | 24427 | 62924319 |
Peripheral swelling | 78.18 | 10.32 | 2882 | 537394 | 263060 | 62685686 |
Abortion spontaneous | 77.16 | 10.32 | 675 | 539601 | 46520 | 62902226 |
Joint effusion | 76.55 | 10.32 | 318 | 539958 | 16742 | 62932004 |
Ill-defined disorder | 76.38 | 10.32 | 1046 | 539230 | 80709 | 62868037 |
Multiple sclerosis relapse | 76.05 | 10.32 | 189 | 540087 | 48289 | 62900457 |
Multiple organ dysfunction syndrome | 75.18 | 10.32 | 240 | 540036 | 56512 | 62892234 |
Myalgia | 74.07 | 10.32 | 843 | 539433 | 145686 | 62803060 |
Drug ineffective for unapproved indication | 73.31 | 10.32 | 110 | 540166 | 33953 | 62914793 |
Drug withdrawal syndrome | 73.07 | 10.32 | 74 | 540202 | 27120 | 62921626 |
Creatinine renal clearance decreased | 72.67 | 10.32 | 24 | 540252 | 16284 | 62932462 |
Device expulsion | 72.08 | 10.32 | 116 | 540160 | 34806 | 62913940 |
Metabolic acidosis | 72.05 | 10.32 | 174 | 540102 | 44895 | 62903851 |
Blood pressure diastolic abnormal | 71.59 | 10.32 | 279 | 539997 | 14263 | 62934483 |
Respiratory failure | 71.35 | 10.32 | 540 | 539736 | 101318 | 62847428 |
Blood pressure systolic abnormal | 70.99 | 10.32 | 263 | 540013 | 13123 | 62935623 |
Blood pressure fluctuation | 70.88 | 10.32 | 653 | 539623 | 45664 | 62903082 |
Altered state of consciousness | 70.87 | 10.32 | 66 | 540210 | 25164 | 62923582 |
Dizziness | 70.79 | 10.32 | 2965 | 537311 | 426960 | 62521786 |
Neuropathy peripheral | 70.31 | 10.32 | 623 | 539653 | 113044 | 62835702 |
Product quality issue | 69.55 | 10.32 | 124 | 540152 | 35741 | 62913005 |
Seizure | 69.43 | 10.32 | 757 | 539519 | 131877 | 62816869 |
Hepatic failure | 69.39 | 10.32 | 123 | 540153 | 35533 | 62913213 |
Angioedema | 69.17 | 10.32 | 195 | 540081 | 47770 | 62900976 |
Metastases to bone | 69.07 | 10.32 | 47 | 540229 | 20972 | 62927774 |
Hepatocellular injury | 68.58 | 10.32 | 79 | 540197 | 27302 | 62921444 |
Chest discomfort | 67.46 | 10.32 | 604 | 539672 | 109365 | 62839381 |
Anaphylactic reaction | 67.26 | 10.32 | 311 | 539965 | 65789 | 62882957 |
Hypoxia | 67.15 | 10.32 | 271 | 540005 | 59521 | 62889225 |
Cardiac failure congestive | 67.15 | 10.32 | 485 | 539791 | 91948 | 62856798 |
Blood glucose increased | 67.05 | 10.32 | 427 | 539849 | 83329 | 62865417 |
Neutrophil count decreased | 66.32 | 10.32 | 251 | 540025 | 56155 | 62892591 |
Foot deformity | 66.19 | 10.32 | 435 | 539841 | 27418 | 62921328 |
Cytomegalovirus infection | 66.02 | 10.32 | 49 | 540227 | 20903 | 62927843 |
Drug ineffective | 65.99 | 10.32 | 9986 | 530290 | 1034779 | 61913967 |
Disability assessment scale score increased | 65.85 | 10.32 | 107 | 540169 | 3126 | 62945620 |
Cholestasis | 65.36 | 10.32 | 93 | 540183 | 29341 | 62919405 |
Palmar-plantar erythrodysaesthesia syndrome | 64.89 | 10.32 | 60 | 540216 | 22955 | 62925791 |
Red blood cell sedimentation rate increased | 64.26 | 10.32 | 614 | 539662 | 43368 | 62905378 |
Sinusitis | 64.12 | 10.32 | 2446 | 537830 | 224207 | 62724539 |
Balance disorder | 62.77 | 10.32 | 440 | 539836 | 83982 | 62864764 |
Hyperkalaemia | 62.56 | 10.32 | 243 | 540033 | 53960 | 62894786 |
Leukopenia | 62.40 | 10.32 | 393 | 539883 | 76897 | 62871849 |
Vision blurred | 62.19 | 10.32 | 492 | 539784 | 91432 | 62857314 |
Hallucination | 61.21 | 10.32 | 249 | 540027 | 54568 | 62894178 |
Ejection fraction decreased | 60.88 | 10.32 | 60 | 540216 | 22272 | 62926474 |
Basal cell carcinoma | 60.46 | 10.32 | 427 | 539849 | 27564 | 62921182 |
Osteonecrosis of jaw | 59.86 | 10.32 | 131 | 540145 | 34992 | 62913754 |
Dehydration | 59.82 | 10.32 | 1076 | 539200 | 172278 | 62776468 |
Product use in unapproved indication | 59.47 | 10.32 | 1119 | 539157 | 177961 | 62770785 |
Anaphylactic shock | 59.39 | 10.32 | 68 | 540208 | 23565 | 62925181 |
Encephalopathy | 57.94 | 10.32 | 154 | 540122 | 38466 | 62910280 |
Poisoning | 57.91 | 10.32 | 22 | 540254 | 13678 | 62935068 |
Feeling abnormal | 57.42 | 10.32 | 902 | 539374 | 147490 | 62801256 |
Diabetic ketoacidosis | 57.17 | 10.32 | 54 | 540222 | 20451 | 62928295 |
Injection site erythema | 56.99 | 10.32 | 1010 | 539266 | 82164 | 62866582 |
Loss of consciousness | 56.81 | 10.32 | 687 | 539589 | 117434 | 62831312 |
Grip strength decreased | 56.61 | 10.32 | 354 | 539922 | 21933 | 62926813 |
Insomnia | 56.41 | 10.32 | 1397 | 538879 | 213855 | 62734891 |
Blood creatine phosphokinase increased | 54.80 | 10.32 | 110 | 540166 | 30320 | 62918426 |
Blood pressure systolic increased | 54.78 | 10.32 | 631 | 539645 | 46766 | 62901980 |
Myocardial infarction | 54.76 | 10.32 | 564 | 539712 | 99329 | 62849417 |
Juvenile idiopathic arthritis | 54.53 | 10.32 | 100 | 540176 | 3226 | 62945520 |
Pulmonary fibrosis | 54.38 | 10.32 | 548 | 539728 | 39261 | 62909485 |
Weight increased | 54.34 | 10.32 | 2727 | 537549 | 258065 | 62690681 |
Mydriasis | 54.33 | 10.32 | 17 | 540259 | 11939 | 62936807 |
COVID-19 | 54.32 | 10.32 | 658 | 539618 | 112445 | 62836301 |
Cytokine release syndrome | 54.14 | 10.32 | 27 | 540249 | 14287 | 62934459 |
Infection | 53.81 | 10.32 | 2425 | 537851 | 226748 | 62721998 |
Restlessness | 53.44 | 10.32 | 106 | 540170 | 29347 | 62919399 |
Osteoporosis | 53.30 | 10.32 | 733 | 539543 | 56605 | 62892141 |
Stomatitis | 53.26 | 10.32 | 1552 | 538724 | 137173 | 62811573 |
Wrong technique in product usage process | 52.93 | 10.32 | 312 | 539964 | 62028 | 62886718 |
Blood calcium decreased | 52.61 | 10.32 | 90 | 540186 | 26361 | 62922385 |
Bone erosion | 52.47 | 10.32 | 293 | 539983 | 17424 | 62931322 |
Gamma-glutamyltransferase increased | 51.58 | 10.32 | 135 | 540141 | 33896 | 62914850 |
Hypokalaemia | 51.35 | 10.32 | 600 | 539676 | 103204 | 62845542 |
Shock | 51.24 | 10.32 | 75 | 540201 | 23388 | 62925358 |
Metastases to liver | 51.20 | 10.32 | 76 | 540200 | 23563 | 62925183 |
Suicidal ideation | 51.11 | 10.32 | 316 | 539960 | 62105 | 62886641 |
White blood cell count decreased | 51.01 | 10.32 | 854 | 539422 | 138250 | 62810496 |
Joint laxity | 50.80 | 10.32 | 82 | 540194 | 2382 | 62946364 |
Blood pressure decreased | 50.76 | 10.32 | 334 | 539942 | 64688 | 62884058 |
Extrapyramidal disorder | 50.33 | 10.32 | 25 | 540251 | 13259 | 62935487 |
Respiratory depression | 50.19 | 10.32 | 27 | 540249 | 13688 | 62935058 |
Disseminated intravascular coagulation | 49.87 | 10.32 | 53 | 540223 | 18998 | 62929748 |
Ventricular tachycardia | 49.65 | 10.32 | 58 | 540218 | 19921 | 62928825 |
Disturbance in attention | 49.53 | 10.32 | 163 | 540113 | 38026 | 62910720 |
Torsade de pointes | 49.28 | 10.32 | 26 | 540250 | 13325 | 62935421 |
Joint range of motion decreased | 48.51 | 10.32 | 455 | 539821 | 31973 | 62916773 |
Cerebral haemorrhage | 48.04 | 10.32 | 120 | 540156 | 30609 | 62918137 |
Caesarean section | 48.02 | 10.32 | 278 | 539998 | 16754 | 62931992 |
Dysphagia | 47.79 | 10.32 | 502 | 539774 | 88083 | 62860663 |
Joint destruction | 47.70 | 10.32 | 139 | 540137 | 6113 | 62942633 |
Platelet count decreased | 47.60 | 10.32 | 698 | 539578 | 115424 | 62833322 |
Drug level increased | 47.42 | 10.32 | 75 | 540201 | 22661 | 62926085 |
Premature labour | 46.95 | 10.32 | 221 | 540055 | 12283 | 62936463 |
Injection site reaction | 46.84 | 10.32 | 729 | 539547 | 57795 | 62890951 |
Drug tolerance decreased | 45.92 | 10.32 | 280 | 539996 | 17193 | 62931553 |
Urticaria | 45.64 | 10.32 | 1068 | 539208 | 164734 | 62784012 |
Loss of personal independence in daily activities | 45.53 | 10.32 | 1117 | 539159 | 96173 | 62852573 |
Inflammation | 45.47 | 10.32 | 967 | 539309 | 81306 | 62867440 |
Accidental exposure to product | 45.24 | 10.32 | 104 | 540172 | 27301 | 62921445 |
Palpitations | 45.13 | 10.32 | 681 | 539595 | 112089 | 62836657 |
Hypothermia | 45.12 | 10.32 | 30 | 540246 | 13551 | 62935195 |
Pulmonary embolism | 44.88 | 10.32 | 710 | 539566 | 115974 | 62832772 |
Myelosuppression | 44.14 | 10.32 | 84 | 540192 | 23619 | 62925127 |
Respiratory disorder | 43.96 | 10.32 | 177 | 540099 | 38905 | 62909841 |
Disorientation | 43.55 | 10.32 | 180 | 540096 | 39272 | 62909474 |
C-reactive protein increased | 43.02 | 10.32 | 1083 | 539193 | 93624 | 62855122 |
Muscle spasticity | 42.57 | 10.32 | 75 | 540201 | 21719 | 62927027 |
Neurotoxicity | 42.57 | 10.32 | 49 | 540227 | 16941 | 62931805 |
Abnormal behaviour | 42.52 | 10.32 | 73 | 540203 | 21353 | 62927393 |
Polyarthritis | 42.33 | 10.32 | 185 | 540091 | 9961 | 62938785 |
Mental status changes | 42.27 | 10.32 | 183 | 540093 | 39416 | 62909330 |
Injection site pruritus | 42.03 | 10.32 | 577 | 539699 | 44539 | 62904207 |
Fluid retention | 41.98 | 10.32 | 316 | 539960 | 59370 | 62889376 |
Akathisia | 41.57 | 10.32 | 13 | 540263 | 9133 | 62939613 |
Device difficult to use | 41.53 | 10.32 | 29 | 540247 | 12767 | 62935979 |
Emotional distress | 41.48 | 10.32 | 140 | 540136 | 32409 | 62916337 |
Blood alkaline phosphatase increased | 41.47 | 10.32 | 206 | 540070 | 42761 | 62905985 |
Speech disorder | 40.83 | 10.32 | 192 | 540084 | 40437 | 62908309 |
Unresponsive to stimuli | 40.71 | 10.32 | 149 | 540127 | 33667 | 62915079 |
Posterior reversible encephalopathy syndrome | 40.33 | 10.32 | 53 | 540223 | 17292 | 62931454 |
Flushing | 40.31 | 10.32 | 426 | 539850 | 74661 | 62874085 |
Vertigo | 39.82 | 10.32 | 322 | 539954 | 59565 | 62889181 |
Acute hepatic failure | 39.62 | 10.32 | 59 | 540217 | 18268 | 62930478 |
Ascites | 39.46 | 10.32 | 195 | 540081 | 40533 | 62908213 |
Chronic kidney disease | 39.18 | 10.32 | 226 | 540050 | 45172 | 62903574 |
Disability | 39.11 | 10.32 | 279 | 539997 | 18068 | 62930678 |
Depression | 38.93 | 10.32 | 1325 | 538951 | 195167 | 62753579 |
Pain in jaw | 38.91 | 10.32 | 214 | 540062 | 43282 | 62905464 |
Polyneuropathy | 38.85 | 10.32 | 40 | 540236 | 14549 | 62934197 |
Blood bilirubin increased | 38.82 | 10.32 | 173 | 540103 | 36967 | 62911779 |
Stress cardiomyopathy | 38.59 | 10.32 | 16 | 540260 | 9434 | 62939312 |
Thrombotic microangiopathy | 38.35 | 10.32 | 21 | 540255 | 10540 | 62938206 |
Dysarthria | 38.28 | 10.32 | 210 | 540066 | 42501 | 62906245 |
Blood pressure diastolic decreased | 38.28 | 10.32 | 327 | 539949 | 22379 | 62926367 |
Disease recurrence | 38.20 | 10.32 | 117 | 540159 | 27913 | 62920833 |
Gestational diabetes | 38.06 | 10.32 | 157 | 540119 | 8239 | 62940507 |
Foetal exposure during pregnancy | 38.05 | 10.32 | 428 | 539848 | 31534 | 62917212 |
Rheumatoid nodule | 37.81 | 10.32 | 263 | 540013 | 16892 | 62931854 |
Neck deformity | 37.62 | 10.32 | 66 | 540210 | 2055 | 62946691 |
Parkinsonism | 37.55 | 10.32 | 21 | 540255 | 10418 | 62938328 |
Diabetes mellitus inadequate control | 37.49 | 10.32 | 44 | 540232 | 15082 | 62933664 |
Schizophrenia | 37.30 | 10.32 | 19 | 540257 | 9933 | 62938813 |
Sepsis | 37.11 | 10.32 | 1005 | 539271 | 152118 | 62796628 |
Toxic skin eruption | 37.03 | 10.32 | 33 | 540243 | 12852 | 62935894 |
Hypomania | 36.98 | 10.32 | 5 | 540271 | 6325 | 62942421 |
Respiratory distress | 36.79 | 10.32 | 156 | 540120 | 33795 | 62914951 |
Hepatotoxicity | 36.66 | 10.32 | 176 | 540100 | 36865 | 62911881 |
Multiple fractures | 36.61 | 10.32 | 158 | 540118 | 8460 | 62940286 |
Exposure to toxic agent | 36.26 | 10.32 | 3 | 540273 | 5584 | 62943162 |
Withdrawal syndrome | 36.25 | 10.32 | 72 | 540204 | 19925 | 62928821 |
Product administration error | 36.17 | 10.32 | 86 | 540190 | 22311 | 62926435 |
Bone pain | 35.78 | 10.32 | 295 | 539981 | 54346 | 62894400 |
Adverse event | 35.71 | 10.32 | 789 | 539487 | 66770 | 62881976 |
Decreased appetite | 35.62 | 10.32 | 1759 | 538517 | 249293 | 62699453 |
Tuberculosis | 35.62 | 10.32 | 189 | 540087 | 11022 | 62937724 |
Psychotic disorder | 35.27 | 10.32 | 107 | 540169 | 25605 | 62923141 |
Pulmonary oedema | 35.14 | 10.32 | 298 | 539978 | 54575 | 62894171 |
Haematotoxicity | 34.99 | 10.32 | 18 | 540258 | 9358 | 62939388 |
Second primary malignancy | 34.92 | 10.32 | 12 | 540264 | 7941 | 62940805 |
Agranulocytosis | 34.91 | 10.32 | 104 | 540172 | 25030 | 62923716 |
Metastases to central nervous system | 34.82 | 10.32 | 36 | 540240 | 13069 | 62935677 |
Dyskinesia | 34.71 | 10.32 | 147 | 540129 | 31855 | 62916891 |
Cerebrovascular accident | 34.61 | 10.32 | 679 | 539597 | 107345 | 62841401 |
Brain oedema | 34.43 | 10.32 | 42 | 540234 | 14153 | 62934593 |
Pyrexia | 34.43 | 10.32 | 3492 | 536784 | 466986 | 62481760 |
Inappropriate antidiuretic hormone secretion | 34.18 | 10.32 | 49 | 540227 | 15413 | 62933333 |
Accidental overdose | 34.17 | 10.32 | 94 | 540182 | 23215 | 62925531 |
Joint stiffness | 34.06 | 10.32 | 523 | 539753 | 41346 | 62907400 |
Dysgeusia | 33.95 | 10.32 | 245 | 540031 | 46465 | 62902281 |
Blood creatinine increased | 33.95 | 10.32 | 534 | 539742 | 87310 | 62861436 |
Eosinophilia | 33.94 | 10.32 | 91 | 540185 | 22665 | 62926081 |
Arrhythmia | 33.93 | 10.32 | 188 | 540088 | 37952 | 62910794 |
Pancreatitis acute | 33.83 | 10.32 | 118 | 540158 | 27048 | 62921698 |
Aspartate aminotransferase increased | 33.82 | 10.32 | 552 | 539724 | 89725 | 62859021 |
Bronchospasm | 33.27 | 10.32 | 60 | 540216 | 17220 | 62931526 |
Gastrointestinal disorder | 33.05 | 10.32 | 1399 | 538877 | 129840 | 62818906 |
Maternal drugs affecting foetus | 33.00 | 10.32 | 109 | 540167 | 5133 | 62943613 |
Transplant rejection | 32.96 | 10.32 | 26 | 540250 | 10754 | 62937992 |
Miosis | 32.45 | 10.32 | 11 | 540265 | 7342 | 62941404 |
Hospitalisation | 32.28 | 10.32 | 519 | 539757 | 84562 | 62864184 |
Atrial fibrillation | 32.17 | 10.32 | 751 | 539525 | 115885 | 62832861 |
Tenderness | 31.90 | 10.32 | 313 | 539963 | 22265 | 62926481 |
Alanine aminotransferase increased | 31.83 | 10.32 | 657 | 539619 | 103113 | 62845633 |
Mania | 31.71 | 10.32 | 35 | 540241 | 12332 | 62936414 |
Haemorrhage | 31.63 | 10.32 | 349 | 539927 | 60673 | 62888073 |
Mobility decreased | 31.52 | 10.32 | 1296 | 538980 | 119863 | 62828883 |
Obstructive airways disorder | 31.46 | 10.32 | 82 | 540194 | 20617 | 62928129 |
Nodule | 31.44 | 10.32 | 295 | 539981 | 20731 | 62928015 |
Forced expiratory volume decreased | 31.34 | 10.32 | 3 | 540273 | 4965 | 62943781 |
Dystonia | 31.34 | 10.32 | 43 | 540233 | 13776 | 62934970 |
Panic attack | 31.30 | 10.32 | 92 | 540184 | 22239 | 62926507 |
Lupus-like syndrome | 31.11 | 10.32 | 230 | 540046 | 15065 | 62933681 |
Tumour lysis syndrome | 31.04 | 10.32 | 19 | 540257 | 8971 | 62939775 |
Off label use | 31.04 | 10.32 | 5156 | 535120 | 669306 | 62279440 |
Pulmonary arterial hypertension | 30.94 | 10.32 | 94 | 540182 | 22483 | 62926263 |
Colitis | 30.87 | 10.32 | 264 | 540012 | 48264 | 62900482 |
Irritability | 30.56 | 10.32 | 152 | 540124 | 31542 | 62917204 |
Atrioventricular block complete | 30.55 | 10.32 | 16 | 540260 | 8235 | 62940511 |
Laryngitis | 30.55 | 10.32 | 248 | 540028 | 16719 | 62932027 |
Maternal exposure before pregnancy | 30.49 | 10.32 | 137 | 540139 | 7466 | 62941280 |
Hemiparesis | 30.45 | 10.32 | 99 | 540177 | 23183 | 62925563 |
Device use error | 30.42 | 10.32 | 6 | 540270 | 5755 | 62942991 |
Ventricular septal defect | 30.26 | 10.32 | 94 | 540182 | 4284 | 62944462 |
General physical health deterioration | 30.21 | 10.32 | 2045 | 538231 | 199357 | 62749389 |
Depressed mood | 30.10 | 10.32 | 209 | 540067 | 39982 | 62908764 |
Acute generalised exanthematous pustulosis | 30.05 | 10.32 | 30 | 540246 | 11069 | 62937677 |
Dyspnoea exertional | 30.03 | 10.32 | 348 | 539928 | 59954 | 62888792 |
Face oedema | 30.01 | 10.32 | 81 | 540195 | 20131 | 62928615 |
Coagulopathy | 30.00 | 10.32 | 83 | 540193 | 20461 | 62928285 |
Neuroleptic malignant syndrome | 29.96 | 10.32 | 35 | 540241 | 12021 | 62936725 |
Pleural effusion | 29.82 | 10.32 | 586 | 539690 | 92624 | 62856122 |
Melaena | 29.63 | 10.32 | 145 | 540131 | 30220 | 62918526 |
Asphyxia | 29.54 | 10.32 | 8 | 540268 | 6173 | 62942573 |
Joint dislocation | 29.24 | 10.32 | 266 | 540010 | 18534 | 62930212 |
Injection site swelling | 29.21 | 10.32 | 568 | 539708 | 47004 | 62901742 |
Chronic sinusitis | 29.09 | 10.32 | 40 | 540236 | 12803 | 62935943 |
Proteinuria | 28.98 | 10.32 | 76 | 540200 | 19069 | 62929677 |
Ischaemic stroke | 28.96 | 10.32 | 69 | 540207 | 17888 | 62930858 |
Ventricular fibrillation | 28.90 | 10.32 | 35 | 540241 | 11832 | 62936914 |
Gastrointestinal haemorrhage | 28.89 | 10.32 | 501 | 539775 | 80675 | 62868071 |
Musculoskeletal pain | 28.76 | 10.32 | 1007 | 539269 | 91270 | 62857476 |
Enthesopathy | 28.60 | 10.32 | 147 | 540129 | 8467 | 62940279 |
Metastases to lung | 28.59 | 10.32 | 40 | 540236 | 12710 | 62936036 |
International normalised ratio increased | 28.45 | 10.32 | 255 | 540021 | 46170 | 62902576 |
Status epilepticus | 28.35 | 10.32 | 54 | 540222 | 15179 | 62933567 |
Heart rate decreased | 28.32 | 10.32 | 545 | 539731 | 45015 | 62903731 |
Procedural pain | 28.01 | 10.32 | 92 | 540184 | 21477 | 62927269 |
Hyperlipidaemia | 27.89 | 10.32 | 80 | 540196 | 19491 | 62929255 |
Pain in extremity | 27.81 | 10.32 | 3225 | 537051 | 328261 | 62620485 |
Latent tuberculosis | 27.81 | 10.32 | 66 | 540210 | 2561 | 62946185 |
Wheelchair user | 27.73 | 10.32 | 117 | 540159 | 6202 | 62942544 |
Substance abuse | 27.61 | 10.32 | 4 | 540272 | 4803 | 62943943 |
Cytopenia | 27.43 | 10.32 | 35 | 540241 | 11566 | 62937180 |
Haemophagocytic lymphohistiocytosis | 27.33 | 10.32 | 30 | 540246 | 10597 | 62938149 |
Sinus tachycardia | 27.24 | 10.32 | 110 | 540166 | 24158 | 62924588 |
Back pain | 27.19 | 10.32 | 1908 | 538368 | 262237 | 62686509 |
Ankylosing spondylitis | 26.99 | 10.32 | 167 | 540109 | 10307 | 62938439 |
Lymphocyte count decreased | 26.99 | 10.32 | 149 | 540127 | 30108 | 62918638 |
Prescribed underdose | 26.96 | 10.32 | 378 | 539898 | 29311 | 62919435 |
Erythema multiforme | 26.95 | 10.32 | 28 | 540248 | 10141 | 62938605 |
Device related infection | 26.91 | 10.32 | 105 | 540171 | 23287 | 62925459 |
Chest pain | 26.88 | 10.32 | 1533 | 538743 | 214426 | 62734320 |
Limb deformity | 26.80 | 10.32 | 85 | 540191 | 3917 | 62944829 |
Graft versus host disease | 26.74 | 10.32 | 12 | 540264 | 6751 | 62941995 |
Blood pressure diastolic increased | 26.68 | 10.32 | 161 | 540115 | 9849 | 62938897 |
Rhinitis allergic | 26.09 | 10.32 | 37 | 540239 | 11690 | 62937056 |
Aggression | 26.06 | 10.32 | 107 | 540169 | 23391 | 62925355 |
Aphasia | 26.01 | 10.32 | 169 | 540107 | 32831 | 62915915 |
Localised infection | 25.98 | 10.32 | 381 | 539895 | 29829 | 62918917 |
Tachypnoea | 25.94 | 10.32 | 69 | 540207 | 17233 | 62931513 |
Cerebral infarction | 25.76 | 10.32 | 110 | 540166 | 23783 | 62924963 |
Temperature regulation disorder | 25.66 | 10.32 | 10 | 540266 | 6122 | 62942624 |
Peripheral venous disease | 25.62 | 10.32 | 222 | 540054 | 15255 | 62933491 |
Nightmare | 25.53 | 10.32 | 81 | 540195 | 19113 | 62929633 |
Small for dates baby | 25.43 | 10.32 | 80 | 540196 | 3671 | 62945075 |
Paralysis | 25.41 | 10.32 | 28 | 540248 | 9872 | 62938874 |
Angina pectoris | 25.28 | 10.32 | 151 | 540125 | 29927 | 62918819 |
Personality disorder | 25.12 | 10.32 | 9 | 540267 | 5802 | 62942944 |
Bronchopulmonary aspergillosis | 24.95 | 10.32 | 22 | 540254 | 8613 | 62940133 |
Paradoxical drug reaction | 24.94 | 10.32 | 3 | 540273 | 4149 | 62944597 |
Acute graft versus host disease | 24.71 | 10.32 | 4 | 540272 | 4424 | 62944322 |
Acute myeloid leukaemia | 24.50 | 10.32 | 70 | 540206 | 17077 | 62931669 |
Deep vein thrombosis | 24.40 | 10.32 | 535 | 539741 | 83265 | 62865481 |
Facet joint syndrome | 24.39 | 10.32 | 182 | 540094 | 11956 | 62936790 |
Malignant mediastinal neoplasm | 24.37 | 10.32 | 44 | 540232 | 1402 | 62947344 |
Smear cervix abnormal | 23.93 | 10.32 | 67 | 540209 | 2879 | 62945867 |
Injection site bruising | 23.93 | 10.32 | 495 | 539781 | 41415 | 62907331 |
Premature rupture of membranes | 23.93 | 10.32 | 95 | 540181 | 4898 | 62943848 |
Obesity | 23.92 | 10.32 | 373 | 539903 | 29579 | 62919167 |
Anuria | 23.79 | 10.32 | 44 | 540232 | 12507 | 62936239 |
Pre-eclampsia | 23.78 | 10.32 | 146 | 540130 | 8987 | 62939759 |
Haemorrhage intracranial | 23.74 | 10.32 | 49 | 540227 | 13370 | 62935376 |
Haemoptysis | 23.73 | 10.32 | 145 | 540131 | 28581 | 62920165 |
Bone marrow failure | 23.60 | 10.32 | 149 | 540127 | 29141 | 62919605 |
Sleep apnoea syndrome | 23.58 | 10.32 | 148 | 540128 | 28985 | 62919761 |
Product dose omission issue | 23.54 | 10.32 | 1696 | 538580 | 232617 | 62716129 |
Nasal polyps | 23.44 | 10.32 | 11 | 540265 | 6028 | 62942718 |
Tenosynovitis | 23.43 | 10.32 | 199 | 540077 | 13596 | 62935150 |
Rash maculo-papular | 23.33 | 10.32 | 167 | 540109 | 31729 | 62917017 |
Purpura | 23.32 | 10.32 | 38 | 540238 | 11347 | 62937399 |
Dry skin | 23.28 | 10.32 | 342 | 539934 | 56545 | 62892201 |
Febrile bone marrow aplasia | 23.25 | 10.32 | 17 | 540259 | 7308 | 62941438 |
Breast cancer stage I | 23.18 | 10.32 | 15 | 540261 | 6874 | 62941872 |
Femur fracture | 23.13 | 10.32 | 491 | 539785 | 41265 | 62907481 |
Tenosynovitis stenosans | 23.04 | 10.32 | 72 | 540204 | 3292 | 62945454 |
Diabetes mellitus | 23.02 | 10.32 | 335 | 539941 | 55475 | 62893271 |
Malaise | 22.90 | 10.32 | 3146 | 537130 | 412808 | 62535938 |
Injection site pain | 22.76 | 10.32 | 1336 | 538940 | 128464 | 62820282 |
Neck mass | 22.75 | 10.32 | 75 | 540201 | 3528 | 62945218 |
Affective disorder | 22.64 | 10.32 | 12 | 540264 | 6134 | 62942612 |
Synovial cyst | 22.44 | 10.32 | 159 | 540117 | 10274 | 62938472 |
Multiple-drug resistance | 22.36 | 10.32 | 8 | 540268 | 5162 | 62943584 |
Cardiogenic shock | 22.26 | 10.32 | 78 | 540198 | 17854 | 62930892 |
Maternal exposure timing unspecified | 22.19 | 10.32 | 119 | 540157 | 6968 | 62941778 |
Complication of device insertion | 22.19 | 10.32 | 19 | 540257 | 7545 | 62941201 |
Red blood cell sedimentation rate | 22.18 | 10.32 | 91 | 540185 | 4763 | 62943983 |
Stevens-Johnson syndrome | 22.18 | 10.32 | 123 | 540153 | 24827 | 62923919 |
Retinitis | 22.17 | 10.32 | 108 | 540168 | 6088 | 62942658 |
Muscle twitching | 22.17 | 10.32 | 89 | 540187 | 19579 | 62929167 |
Complication of device removal | 22.17 | 10.32 | 8 | 540268 | 5134 | 62943612 |
Exostosis | 22.09 | 10.32 | 241 | 540035 | 17621 | 62931125 |
Sexual dysfunction | 22.08 | 10.32 | 5 | 540271 | 4354 | 62944392 |
Labelled drug-drug interaction medication error | 21.99 | 10.32 | 51 | 540225 | 13348 | 62935398 |
Muscle spasms | 21.94 | 10.32 | 1095 | 539181 | 155055 | 62793691 |
Rotator cuff repair | 21.93 | 10.32 | 53 | 540223 | 2081 | 62946665 |
Dislocation of vertebra | 21.83 | 10.32 | 137 | 540139 | 8498 | 62940248 |
Acute respiratory failure | 21.75 | 10.32 | 188 | 540088 | 34297 | 62914449 |
Infective pulmonary exacerbation of cystic fibrosis | 21.48 | 10.32 | 26 | 540250 | 8791 | 62939955 |
Dysmorphism | 21.46 | 10.32 | 55 | 540221 | 2241 | 62946505 |
Pulmonary hypertension | 21.41 | 10.32 | 207 | 540069 | 36916 | 62911830 |
Clostridium difficile colitis | 21.38 | 10.32 | 96 | 540180 | 20473 | 62928273 |
Glycosylated haemoglobin increased | 21.32 | 10.32 | 46 | 540230 | 12352 | 62936394 |
Abdominal pain | 21.29 | 10.32 | 2179 | 538097 | 291277 | 62657469 |
Wound infection | 21.25 | 10.32 | 277 | 539999 | 21133 | 62927613 |
Lip dry | 21.14 | 10.32 | 213 | 540063 | 15257 | 62933489 |
Arthritis infective | 21.12 | 10.32 | 110 | 540166 | 6368 | 62942378 |
Skin papilloma | 21.03 | 10.32 | 91 | 540185 | 4878 | 62943868 |
Developmental hip dysplasia | 20.93 | 10.32 | 40 | 540236 | 1332 | 62947414 |
Anti-cyclic citrullinated peptide antibody | 20.84 | 10.32 | 113 | 540163 | 6645 | 62942101 |
Genital haemorrhage | 20.80 | 10.32 | 19 | 540257 | 7313 | 62941433 |
Placental disorder | 20.71 | 10.32 | 42 | 540234 | 1462 | 62947284 |
Coronary artery disease | 20.65 | 10.32 | 176 | 540100 | 32201 | 62916545 |
Aspergillus infection | 20.65 | 10.32 | 23 | 540253 | 8070 | 62940676 |
Body temperature decreased | 20.64 | 10.32 | 264 | 540012 | 20055 | 62928691 |
Urinary retention | 20.57 | 10.32 | 162 | 540114 | 30139 | 62918607 |
Hypothyroidism | 20.46 | 10.32 | 248 | 540028 | 42384 | 62906362 |
Malignant melanoma | 20.45 | 10.32 | 166 | 540110 | 11190 | 62937556 |
Cardiotoxicity | 20.43 | 10.32 | 25 | 540251 | 8413 | 62940333 |
Synovial fluid analysis | 20.43 | 10.32 | 56 | 540220 | 2377 | 62946369 |
Schizoaffective disorder | 20.37 | 10.32 | 3 | 540273 | 3559 | 62945187 |
Crying | 20.25 | 10.32 | 116 | 540160 | 23227 | 62925519 |
Injection site rash | 20.23 | 10.32 | 247 | 540029 | 18562 | 62930184 |
Lip swelling | 20.20 | 10.32 | 168 | 540108 | 30895 | 62917851 |
Rash erythematous | 20.14 | 10.32 | 248 | 540028 | 42262 | 62906484 |
Hallucination, auditory | 20.11 | 10.32 | 50 | 540226 | 12774 | 62935972 |
Body height below normal | 20.10 | 10.32 | 52 | 540224 | 2131 | 62946615 |
Prescribed overdose | 20.03 | 10.32 | 405 | 539871 | 33748 | 62914998 |
Gastroenteritis viral | 20.03 | 10.32 | 298 | 539978 | 23402 | 62925344 |
Bradyphrenia | 19.91 | 10.32 | 18 | 540258 | 6962 | 62941784 |
Acute respiratory distress syndrome | 19.86 | 10.32 | 118 | 540158 | 23416 | 62925330 |
Skin exfoliation | 19.84 | 10.32 | 253 | 540023 | 42849 | 62905897 |
Cough | 19.72 | 10.32 | 2185 | 538091 | 290558 | 62658188 |
Pemphigoid | 19.71 | 10.32 | 20 | 540256 | 7324 | 62941422 |
Myoclonus | 19.71 | 10.32 | 69 | 540207 | 15799 | 62932947 |
Swollen tongue | 19.67 | 10.32 | 195 | 540081 | 34605 | 62914141 |
Acute graft versus host disease in skin | 19.53 | 10.32 | 3 | 540273 | 3449 | 62945297 |
Hallucination, visual | 19.50 | 10.32 | 91 | 540185 | 19207 | 62929539 |
Lethargy | 19.50 | 10.32 | 347 | 539929 | 55660 | 62893086 |
Dermatitis atopic | 19.41 | 10.32 | 33 | 540243 | 9691 | 62939055 |
Adjustment disorder with depressed mood | 19.38 | 10.32 | 151 | 540125 | 10053 | 62938693 |
Paraesthesia oral | 19.35 | 10.32 | 91 | 540185 | 19165 | 62929581 |
Hypomagnesaemia | 19.34 | 10.32 | 154 | 540122 | 28583 | 62920163 |
Therapeutic response decreased | 19.32 | 10.32 | 672 | 539604 | 60853 | 62887893 |
Abdominal distension | 19.32 | 10.32 | 575 | 539701 | 86040 | 62862706 |
Hemiplegia | 19.21 | 10.32 | 31 | 540245 | 9292 | 62939454 |
Skin ulcer | 19.17 | 10.32 | 491 | 539785 | 42554 | 62906192 |
Synovial disorder | 19.13 | 10.32 | 49 | 540227 | 1996 | 62946750 |
Nervousness | 19.05 | 10.32 | 170 | 540106 | 30809 | 62917937 |
Loose body in joint | 19.02 | 10.32 | 37 | 540239 | 1249 | 62947497 |
Pseudomonas infection | 18.96 | 10.32 | 42 | 540234 | 11171 | 62937575 |
Sinus bradycardia | 18.94 | 10.32 | 62 | 540214 | 14489 | 62934257 |
Cardiomyopathy | 18.93 | 10.32 | 81 | 540195 | 17503 | 62931243 |
Headache | 18.89 | 10.32 | 4946 | 535330 | 628295 | 62320451 |
Mental disorder | 18.81 | 10.32 | 136 | 540140 | 25783 | 62922963 |
Chills | 18.77 | 10.32 | 781 | 539495 | 112597 | 62836149 |
Lymphopenia | 18.77 | 10.32 | 86 | 540190 | 18241 | 62930505 |
Tardive dyskinesia | 18.74 | 10.32 | 27 | 540249 | 8475 | 62940271 |
Hyperprolactinaemia | 18.73 | 10.32 | 5 | 540271 | 3895 | 62944851 |
Jaundice | 18.66 | 10.32 | 159 | 540117 | 29092 | 62919654 |
Fear | 18.63 | 10.32 | 70 | 540206 | 15696 | 62933050 |
Erythema | 18.48 | 10.32 | 1267 | 539009 | 174484 | 62774262 |
Hallucinations, mixed | 18.43 | 10.32 | 9 | 540267 | 4820 | 62943926 |
Leukocytosis | 18.38 | 10.32 | 137 | 540139 | 25798 | 62922948 |
Pulmonary congestion | 18.28 | 10.32 | 81 | 540195 | 17337 | 62931409 |
Deep vein thrombosis postoperative | 18.26 | 10.32 | 162 | 540114 | 11207 | 62937539 |
Cyanosis | 18.23 | 10.32 | 78 | 540198 | 16857 | 62931889 |
Hepatitis acute | 18.16 | 10.32 | 31 | 540245 | 9089 | 62939657 |
Atrioventricular block | 18.16 | 10.32 | 23 | 540253 | 7624 | 62941122 |
Foetal anticonvulsant syndrome | 18.09 | 10.32 | 24 | 540252 | 581 | 62948165 |
Pancreatitis | 18.02 | 10.32 | 301 | 539975 | 48754 | 62899992 |
Lymphoedema | 18.01 | 10.32 | 46 | 540230 | 11646 | 62937100 |
Psychomotor hyperactivity | 17.98 | 10.32 | 40 | 540236 | 10623 | 62938123 |
Infusion site pain | 17.98 | 10.32 | 78 | 540198 | 16791 | 62931955 |
Therapy partial responder | 17.95 | 10.32 | 40 | 540236 | 10618 | 62938128 |
Systemic inflammatory response syndrome | 17.90 | 10.32 | 13 | 540263 | 5608 | 62943138 |
Acute chest syndrome | 17.86 | 10.32 | 28 | 540248 | 793 | 62947953 |
Anhedonia | 17.83 | 10.32 | 42 | 540234 | 10932 | 62937814 |
Spinal stenosis | 17.83 | 10.32 | 200 | 540076 | 14725 | 62934021 |
Tubulointerstitial nephritis | 17.76 | 10.32 | 98 | 540178 | 19805 | 62928941 |
Acute myocardial infarction | 17.75 | 10.32 | 181 | 540095 | 31943 | 62916803 |
Memory impairment | 17.73 | 10.32 | 716 | 539560 | 103542 | 62845204 |
Blood glucose decreased | 17.71 | 10.32 | 105 | 540171 | 20847 | 62927899 |
Shock haemorrhagic | 17.62 | 10.32 | 36 | 540240 | 9859 | 62938887 |
Clear cell renal cell carcinoma | 17.59 | 10.32 | 39 | 540237 | 1446 | 62947300 |
Cardiac failure acute | 17.51 | 10.32 | 34 | 540242 | 9489 | 62939257 |
Atrial septal defect | 17.49 | 10.32 | 110 | 540166 | 6828 | 62941918 |
Rheumatoid lung | 17.48 | 10.32 | 72 | 540204 | 3776 | 62944970 |
Circulatory collapse | 17.47 | 10.32 | 112 | 540164 | 21826 | 62926920 |
Jaundice cholestatic | 17.42 | 10.32 | 22 | 540254 | 7302 | 62941444 |
Vascular device infection | 17.35 | 10.32 | 22 | 540254 | 7290 | 62941456 |
Incorrect product administration duration | 17.35 | 10.32 | 46 | 540230 | 11500 | 62937246 |
Epstein-Barr virus infection | 17.32 | 10.32 | 26 | 540250 | 8024 | 62940722 |
Antinuclear antibody positive | 17.26 | 10.32 | 122 | 540154 | 7877 | 62940869 |
Transplant dysfunction | 17.24 | 10.32 | 10 | 540266 | 4862 | 62943884 |
Pericardial effusion | 17.17 | 10.32 | 168 | 540108 | 29890 | 62918856 |
Oliguria | 17.17 | 10.32 | 32 | 540244 | 9069 | 62939677 |
Hepatitis B reactivation | 17.14 | 10.32 | 3 | 540273 | 3134 | 62945612 |
Renal injury | 17.10 | 10.32 | 34 | 540242 | 9405 | 62939341 |
Delirium | 17.01 | 10.32 | 315 | 539961 | 50226 | 62898520 |
Ileus | 17.00 | 10.32 | 66 | 540210 | 14659 | 62934087 |
Ketoacidosis | 16.95 | 10.32 | 8 | 540268 | 4370 | 62944376 |
Sensitisation | 16.92 | 10.32 | 4 | 540272 | 3382 | 62945364 |
Multiple drug therapy | 16.90 | 10.32 | 5 | 540271 | 3641 | 62945105 |
Neutropenic colitis | 16.82 | 10.32 | 3 | 540273 | 3092 | 62945654 |
Tinnitus | 16.82 | 10.32 | 208 | 540068 | 35420 | 62913326 |
Hyperthyroidism | 16.79 | 10.32 | 66 | 540210 | 14607 | 62934139 |
Blood potassium decreased | 16.73 | 10.32 | 254 | 540022 | 41772 | 62906974 |
Muscular weakness | 16.61 | 10.32 | 861 | 539415 | 121492 | 62827254 |
Complication associated with device | 16.61 | 10.32 | 81 | 540195 | 16897 | 62931849 |
Colitis microscopic | 16.61 | 10.32 | 34 | 540242 | 9305 | 62939441 |
Paranoia | 16.45 | 10.32 | 48 | 540228 | 11631 | 62937115 |
Scleritis | 16.43 | 10.32 | 78 | 540198 | 4350 | 62944396 |
Dysuria | 16.29 | 10.32 | 196 | 540080 | 33542 | 62915204 |
Eating disorder | 16.23 | 10.32 | 95 | 540181 | 18921 | 62929825 |
Bradypnoea | 16.22 | 10.32 | 5 | 540271 | 3545 | 62945201 |
Haematoma | 16.17 | 10.32 | 204 | 540072 | 34616 | 62914130 |
Polyuria | 16.14 | 10.32 | 30 | 540246 | 8512 | 62940234 |
Congenital arterial malformation | 16.12 | 10.32 | 17 | 540259 | 320 | 62948426 |
Eosinophil count increased | 16.07 | 10.32 | 44 | 540232 | 10884 | 62937862 |
Bursitis | 16.06 | 10.32 | 421 | 539855 | 36620 | 62912126 |
Product administered to patient of inappropriate age | 16.05 | 10.32 | 4 | 540272 | 3264 | 62945482 |
Human antichimeric antibody positive | 15.96 | 10.32 | 41 | 540235 | 1673 | 62947073 |
Mucosal inflammation | 15.94 | 10.32 | 292 | 539984 | 46636 | 62902110 |
Polyhydramnios | 15.92 | 10.32 | 49 | 540227 | 2222 | 62946524 |
Antibody test positive | 15.90 | 10.32 | 55 | 540221 | 2652 | 62946094 |
Product preparation error | 15.89 | 10.32 | 17 | 540259 | 6075 | 62942671 |
Graft versus host disease in gastrointestinal tract | 15.86 | 10.32 | 4 | 540272 | 3237 | 62945509 |
Immune reconstitution inflammatory syndrome | 15.84 | 10.32 | 17 | 540259 | 6067 | 62942679 |
Urinary incontinence | 15.84 | 10.32 | 185 | 540091 | 31829 | 62916917 |
Sleep disorder due to a general medical condition | 15.82 | 10.32 | 52 | 540224 | 12136 | 62936610 |
Renal disorder | 15.76 | 10.32 | 192 | 540084 | 32782 | 62915964 |
Generalised oedema | 15.75 | 10.32 | 75 | 540201 | 15743 | 62933003 |
Pulmonary tuberculosis | 15.64 | 10.32 | 78 | 540198 | 4439 | 62944307 |
Myocarditis | 15.62 | 10.32 | 41 | 540235 | 10284 | 62938462 |
Cytomegalovirus viraemia | 15.60 | 10.32 | 15 | 540261 | 5634 | 62943112 |
Affect lability | 15.59 | 10.32 | 46 | 540230 | 11105 | 62937641 |
Skin cancer | 15.58 | 10.32 | 158 | 540118 | 11337 | 62937409 |
Proctitis | 15.56 | 10.32 | 14 | 540262 | 5427 | 62943319 |
Cyst | 15.53 | 10.32 | 186 | 540090 | 13913 | 62934833 |
Acute coronary syndrome | 15.47 | 10.32 | 40 | 540236 | 10086 | 62938660 |
Klebsiella infection | 15.39 | 10.32 | 31 | 540245 | 8535 | 62940211 |
Salivary hypersecretion | 15.32 | 10.32 | 26 | 540250 | 7640 | 62941106 |
Acidosis | 15.23 | 10.32 | 47 | 540229 | 11186 | 62937560 |
Hyperuricaemia | 15.14 | 10.32 | 14 | 540262 | 5356 | 62943390 |
Right ventricular failure | 15.13 | 10.32 | 85 | 540191 | 17103 | 62931643 |
Respiratory acidosis | 15.12 | 10.32 | 21 | 540255 | 6694 | 62942052 |
Body temperature increased | 15.08 | 10.32 | 224 | 540052 | 36968 | 62911778 |
Cholecystitis chronic | 15.03 | 10.32 | 42 | 540234 | 10319 | 62938427 |
Bundle branch block left | 14.99 | 10.32 | 23 | 540253 | 7036 | 62941710 |
Product prescribing error | 14.99 | 10.32 | 147 | 540129 | 26142 | 62922604 |
Hyperlactacidaemia | 14.98 | 10.32 | 3 | 540273 | 2846 | 62945900 |
Muscle rigidity | 14.97 | 10.32 | 49 | 540227 | 11451 | 62937295 |
Fracture delayed union | 14.92 | 10.32 | 50 | 540226 | 2372 | 62946374 |
Product adhesion issue | 14.91 | 10.32 | 11 | 540265 | 4708 | 62944038 |
Breast cancer female | 14.88 | 10.32 | 62 | 540214 | 13497 | 62935249 |
Ear infection | 14.78 | 10.32 | 428 | 539848 | 37785 | 62910961 |
Multiple allergies | 14.60 | 10.32 | 64 | 540212 | 13738 | 62935008 |
Stillbirth | 14.59 | 10.32 | 103 | 540173 | 6647 | 62942099 |
Atrial tachycardia | 14.59 | 10.32 | 9 | 540267 | 4231 | 62944515 |
Pulseless electrical activity | 14.58 | 10.32 | 26 | 540250 | 7495 | 62941251 |
Carotid artery thrombosis | 14.57 | 10.32 | 3 | 540273 | 2791 | 62945955 |
Rectal haemorrhage | 14.56 | 10.32 | 312 | 539964 | 48718 | 62900028 |
Hypertransaminasaemia | 14.56 | 10.32 | 21 | 540255 | 6588 | 62942158 |
Personality change | 14.54 | 10.32 | 23 | 540253 | 6950 | 62941796 |
Lupus vulgaris | 14.47 | 10.32 | 94 | 540182 | 5900 | 62942846 |
Tendonitis | 14.44 | 10.32 | 241 | 540035 | 19374 | 62929372 |
Injection site warmth | 14.42 | 10.32 | 195 | 540081 | 15000 | 62933746 |
Middle insomnia | 14.38 | 10.32 | 57 | 540219 | 12586 | 62936160 |
Paraesthesia | 14.35 | 10.32 | 1145 | 539131 | 155821 | 62792925 |
Myopathy | 14.35 | 10.32 | 48 | 540228 | 11143 | 62937603 |
Laryngospasm | 14.32 | 10.32 | 4 | 540272 | 3024 | 62945722 |
Starvation ketoacidosis | 14.32 | 10.32 | 9 | 540267 | 77 | 62948669 |
Aspiration | 14.29 | 10.32 | 46 | 540230 | 10805 | 62937941 |
Peripheral sensory neuropathy | 14.23 | 10.32 | 26 | 540250 | 7425 | 62941321 |
Subdural haematoma | 14.22 | 10.32 | 68 | 540208 | 14260 | 62934486 |
Cushingoid | 14.20 | 10.32 | 122 | 540154 | 8363 | 62940383 |
Breast feeding | 14.17 | 10.32 | 26 | 540250 | 839 | 62947907 |
Fear of injection | 14.16 | 10.32 | 107 | 540169 | 7057 | 62941689 |
Device dislocation | 14.13 | 10.32 | 145 | 540131 | 25560 | 62923186 |
Hepatitis cholestatic | 14.05 | 10.32 | 23 | 540253 | 6855 | 62941891 |
Blood parathyroid hormone decreased | 13.96 | 10.32 | 136 | 540140 | 9655 | 62939091 |
Fall | 13.95 | 10.32 | 3039 | 537237 | 389295 | 62559451 |
Electrocardiogram QRS complex prolonged | 13.95 | 10.32 | 18 | 540258 | 5920 | 62942826 |
Food allergy | 13.88 | 10.32 | 50 | 540226 | 11351 | 62937395 |
Injury | 13.82 | 10.32 | 759 | 539517 | 72488 | 62876258 |
Device breakage | 13.80 | 10.32 | 51 | 540225 | 11491 | 62937255 |
Postoperative wound infection | 13.78 | 10.32 | 148 | 540128 | 10777 | 62937969 |
Delusion | 13.78 | 10.32 | 54 | 540222 | 11963 | 62936783 |
Hypervolaemia | 13.74 | 10.32 | 165 | 540111 | 28248 | 62920498 |
Bone lesion | 13.64 | 10.32 | 18 | 540258 | 5863 | 62942883 |
Skin toxicity | 13.63 | 10.32 | 12 | 540264 | 4702 | 62944044 |
Colorectal cancer | 13.60 | 10.32 | 7 | 540269 | 3638 | 62945108 |
Presyncope | 13.58 | 10.32 | 161 | 540115 | 27624 | 62921122 |
Reversible cerebral vasoconstriction syndrome | 13.56 | 10.32 | 3 | 540273 | 2655 | 62946091 |
Respiration abnormal | 13.54 | 10.32 | 21 | 540255 | 6396 | 62942350 |
Exomphalos | 13.53 | 10.32 | 20 | 540256 | 537 | 62948209 |
Visual impairment | 13.50 | 10.32 | 584 | 539692 | 83862 | 62864884 |
Oedema peripheral | 13.48 | 10.32 | 1409 | 538867 | 188102 | 62760644 |
Hypophagia | 13.47 | 10.32 | 186 | 540090 | 31073 | 62917673 |
Pathogen resistance | 13.44 | 10.32 | 21 | 540255 | 6377 | 62942369 |
Granuloma skin | 13.44 | 10.32 | 120 | 540156 | 8317 | 62940429 |
Metastases to lymph nodes | 13.43 | 10.32 | 31 | 540245 | 8127 | 62940619 |
Dermatitis exfoliative | 13.40 | 10.32 | 16 | 540260 | 5443 | 62943303 |
Hyperthermia | 13.36 | 10.32 | 37 | 540239 | 9119 | 62939627 |
Pulmonary alveolar haemorrhage | 13.36 | 10.32 | 12 | 540264 | 4656 | 62944090 |
Coordination abnormal | 13.31 | 10.32 | 66 | 540210 | 13707 | 62935039 |
Head injury | 13.29 | 10.32 | 159 | 540117 | 27237 | 62921509 |
Abortion incomplete | 13.28 | 10.32 | 5 | 540271 | 3126 | 62945620 |
Illness | 13.21 | 10.32 | 317 | 539959 | 48742 | 62900004 |
Speech disorder developmental | 13.17 | 10.32 | 22 | 540254 | 658 | 62948088 |
Amylase increased | 13.16 | 10.32 | 21 | 540255 | 6324 | 62942422 |
Fracture | 13.12 | 10.32 | 237 | 540039 | 19347 | 62929399 |
Adenovirus infection | 13.11 | 10.32 | 7 | 540269 | 3564 | 62945182 |
Crohn's disease | 13.08 | 10.32 | 79 | 540197 | 4834 | 62943912 |
Chronic graft versus host disease | 13.08 | 10.32 | 5 | 540271 | 3097 | 62945649 |
Product substitution issue | 13.08 | 10.32 | 81 | 540195 | 15915 | 62932831 |
Treatment noncompliance | 13.07 | 10.32 | 231 | 540045 | 37094 | 62911652 |
Gastroschisis | 12.99 | 10.32 | 17 | 540259 | 406 | 62948340 |
Dementia | 12.98 | 10.32 | 100 | 540176 | 18694 | 62930052 |
Bundle branch block right | 12.98 | 10.32 | 14 | 540262 | 4984 | 62943762 |
Hypoglycaemic coma | 12.95 | 10.32 | 3 | 540273 | 2572 | 62946174 |
Short stature | 12.93 | 10.32 | 22 | 540254 | 668 | 62948078 |
Mood altered | 12.93 | 10.32 | 73 | 540203 | 14670 | 62934076 |
Subarachnoid haemorrhage | 12.92 | 10.32 | 70 | 540206 | 14213 | 62934533 |
Pulmonary haemorrhage | 12.89 | 10.32 | 26 | 540250 | 7155 | 62941591 |
Hypercholesterolaemia | 12.85 | 10.32 | 254 | 540022 | 21080 | 62927666 |
Blood urea increased | 12.83 | 10.32 | 153 | 540123 | 26226 | 62922520 |
Autism spectrum disorder | 12.83 | 10.32 | 25 | 540251 | 845 | 62947901 |
Pallor | 12.77 | 10.32 | 183 | 540093 | 30385 | 62918361 |
Nasal obstruction | 12.74 | 10.32 | 38 | 540238 | 1693 | 62947053 |
Nephropathy toxic | 12.61 | 10.32 | 40 | 540236 | 9439 | 62939307 |
HIV-associated neurocognitive disorder | 12.59 | 10.32 | 10 | 540266 | 128 | 62948618 |
Feeling hot | 12.58 | 10.32 | 329 | 539947 | 50025 | 62898721 |
Toxic encephalopathy | 12.53 | 10.32 | 23 | 540253 | 6556 | 62942190 |
Rebound effect | 12.52 | 10.32 | 12 | 540264 | 4514 | 62944232 |
Tumour marker increased | 12.50 | 10.32 | 14 | 540262 | 4901 | 62943845 |
Premature delivery | 12.50 | 10.32 | 342 | 539934 | 29939 | 62918807 |
Maternal exposure during breast feeding | 12.47 | 10.32 | 70 | 540206 | 4171 | 62944575 |
Visual acuity reduced | 12.46 | 10.32 | 122 | 540154 | 21704 | 62927042 |
Blood lactic acid increased | 12.43 | 10.32 | 26 | 540250 | 7060 | 62941686 |
Pregnancy with contraceptive device | 12.35 | 10.32 | 13 | 540263 | 4681 | 62944065 |
Epistaxis | 12.24 | 10.32 | 500 | 539776 | 72225 | 62876521 |
Lymph gland infection | 12.22 | 10.32 | 18 | 540258 | 482 | 62948264 |
Onychomycosis | 12.22 | 10.32 | 112 | 540164 | 7820 | 62940926 |
Cholestasis of pregnancy | 12.14 | 10.32 | 30 | 540246 | 1195 | 62947551 |
Intracranial pressure increased | 12.12 | 10.32 | 16 | 540260 | 5211 | 62943535 |
Hepatic cytolysis | 12.09 | 10.32 | 79 | 540197 | 15328 | 62933418 |
Haemorrhage in pregnancy | 12.09 | 10.32 | 40 | 540236 | 1885 | 62946861 |
Progressive multifocal leukoencephalopathy | 12.05 | 10.32 | 63 | 540213 | 12908 | 62935838 |
Body mass index decreased | 12.05 | 10.32 | 17 | 540259 | 437 | 62948309 |
Renal tubular necrosis | 12.01 | 10.32 | 56 | 540220 | 11822 | 62936924 |
Transaminases increased | 12.00 | 10.32 | 191 | 540085 | 31176 | 62917570 |
Inadequate analgesia | 11.99 | 10.32 | 5 | 540271 | 2938 | 62945808 |
Ulcer | 11.98 | 10.32 | 299 | 539977 | 25808 | 62922938 |
Joint noise | 11.94 | 10.32 | 71 | 540205 | 4321 | 62944425 |
Joint lock | 11.92 | 10.32 | 45 | 540231 | 2266 | 62946480 |
Dermatitis acneiform | 11.89 | 10.32 | 15 | 540261 | 4981 | 62943765 |
Sleep terror | 11.84 | 10.32 | 4 | 540272 | 2676 | 62946070 |
Sciatica | 11.82 | 10.32 | 379 | 539897 | 33945 | 62914801 |
Product physical issue | 11.80 | 10.32 | 15 | 540261 | 4965 | 62943781 |
Congenital cerebral cyst | 11.79 | 10.32 | 13 | 540263 | 258 | 62948488 |
Oligoarthritis | 11.77 | 10.32 | 19 | 540257 | 552 | 62948194 |
Disturbance in social behaviour | 11.75 | 10.32 | 10 | 540266 | 3983 | 62944763 |
Learning disorder | 11.74 | 10.32 | 21 | 540255 | 664 | 62948082 |
Ejection fraction | 11.71 | 10.32 | 3 | 540273 | 2403 | 62946343 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 11.69 | 10.32 | 5 | 540271 | 2894 | 62945852 |
Ankle arthroplasty | 11.68 | 10.32 | 38 | 540238 | 1775 | 62946971 |
Contrast media allergy | 11.68 | 10.32 | 3 | 540273 | 2398 | 62946348 |
Polydipsia | 11.67 | 10.32 | 8 | 540268 | 3556 | 62945190 |
Cardiac disorder | 11.66 | 10.32 | 336 | 539940 | 50480 | 62898266 |
Blood lactate dehydrogenase increased | 11.66 | 10.32 | 133 | 540143 | 22983 | 62925763 |
Pruritus genital | 11.66 | 10.32 | 4 | 540272 | 2650 | 62946096 |
Hypertelorism | 11.66 | 10.32 | 17 | 540259 | 451 | 62948295 |
Multiple sclerosis | 11.61 | 10.32 | 142 | 540134 | 24230 | 62924516 |
Hypoventilation | 11.60 | 10.32 | 14 | 540262 | 4740 | 62944006 |
Gestational hypertension | 11.59 | 10.32 | 46 | 540230 | 2371 | 62946375 |
Pneumonia viral | 11.57 | 10.32 | 32 | 540244 | 7890 | 62940856 |
Ileus paralytic | 11.54 | 10.32 | 13 | 540263 | 4538 | 62944208 |
Talipes | 11.52 | 10.32 | 34 | 540242 | 1506 | 62947240 |
Catheter site pain | 11.49 | 10.32 | 14 | 540262 | 4721 | 62944025 |
Blood iron increased | 11.49 | 10.32 | 34 | 540242 | 1508 | 62947238 |
Intervertebral disc degeneration | 11.47 | 10.32 | 193 | 540083 | 15539 | 62933207 |
Diabetes insipidus | 11.46 | 10.32 | 4 | 540272 | 2621 | 62946125 |
Foetal distress syndrome | 11.44 | 10.32 | 31 | 540245 | 1307 | 62947439 |
Squamous cell carcinoma | 11.39 | 10.32 | 118 | 540158 | 8514 | 62940232 |
Haemodynamic instability | 11.39 | 10.32 | 40 | 540236 | 9150 | 62939596 |
Hot flush | 11.31 | 10.32 | 340 | 539936 | 50819 | 62897927 |
Induced labour | 11.29 | 10.32 | 25 | 540251 | 926 | 62947820 |
Wrong product administered | 11.23 | 10.32 | 22 | 540254 | 6119 | 62942627 |
Bacteraemia | 11.20 | 10.32 | 94 | 540182 | 17254 | 62931492 |
Dactylitis | 11.18 | 10.32 | 48 | 540228 | 2564 | 62946182 |
Toxic epidermal necrolysis | 11.18 | 10.32 | 150 | 540126 | 25184 | 62923562 |
Panniculitis | 11.17 | 10.32 | 147 | 540129 | 11238 | 62937508 |
Device issue | 11.16 | 10.32 | 139 | 540137 | 23642 | 62925104 |
Skin plaque | 11.14 | 10.32 | 35 | 540241 | 8285 | 62940461 |
Myocardial ischaemia | 11.10 | 10.32 | 64 | 540212 | 12795 | 62935951 |
Plasma cell myeloma | 11.10 | 10.32 | 227 | 540049 | 35678 | 62913068 |
Catheter site erythema | 11.08 | 10.32 | 12 | 540264 | 4264 | 62944482 |
Ingrown hair | 11.05 | 10.32 | 19 | 540257 | 582 | 62948164 |
Hepatitis fulminant | 11.05 | 10.32 | 8 | 540268 | 3456 | 62945290 |
Nail injury | 11.04 | 10.32 | 20 | 540256 | 639 | 62948107 |
Uterine perforation | 11.03 | 10.32 | 27 | 540249 | 6936 | 62941810 |
Cyst rupture | 11.00 | 10.32 | 20 | 540256 | 641 | 62948105 |
Human anti-human antibody test | 10.98 | 10.32 | 16 | 540260 | 424 | 62948322 |
Alcoholic liver disease | 10.97 | 10.32 | 9 | 540267 | 121 | 62948625 |
Tongue disorder | 10.97 | 10.32 | 138 | 540138 | 10442 | 62938304 |
Serum ferritin increased | 10.94 | 10.32 | 90 | 540186 | 6092 | 62942654 |
Immunosuppression | 10.93 | 10.32 | 119 | 540157 | 8695 | 62940051 |
Hypernatraemia | 10.92 | 10.32 | 31 | 540245 | 7578 | 62941168 |
Lymphatic fistula | 10.88 | 10.32 | 22 | 540254 | 764 | 62947982 |
Bronchial secretion retention | 10.84 | 10.32 | 5 | 540271 | 2768 | 62945978 |
Terminal state | 10.82 | 10.32 | 3 | 540273 | 2279 | 62946467 |
Injection site haematoma | 10.79 | 10.32 | 97 | 540179 | 6735 | 62942011 |
Drug screen positive | 10.79 | 10.32 | 9 | 540267 | 3620 | 62945126 |
Immune effector cell-associated neurotoxicity syndrome | 10.78 | 10.32 | 3 | 540273 | 2274 | 62946472 |
Anger | 10.75 | 10.32 | 62 | 540214 | 12394 | 62936352 |
Neutrophilia | 10.73 | 10.32 | 13 | 540263 | 4393 | 62944353 |
Haematemesis | 10.72 | 10.32 | 188 | 540088 | 30224 | 62918522 |
Hereditary angioedema | 10.71 | 10.32 | 31 | 540245 | 7531 | 62941215 |
Infusion site erythema | 10.70 | 10.32 | 57 | 540219 | 11622 | 62937124 |
Cervical incompetence | 10.69 | 10.32 | 19 | 540257 | 598 | 62948148 |
Epilepsy | 10.63 | 10.32 | 164 | 540112 | 26901 | 62921845 |
Oropharyngeal pain | 10.60 | 10.32 | 938 | 539338 | 93549 | 62855197 |
Atrial flutter | 10.53 | 10.32 | 45 | 540231 | 9727 | 62939019 |
Infusion site swelling | 10.52 | 10.32 | 45 | 540231 | 9725 | 62939021 |
Glomerular filtration rate decreased | 10.51 | 10.32 | 69 | 540207 | 13372 | 62935374 |
Product residue present | 10.49 | 10.32 | 11 | 540265 | 3968 | 62944778 |
Acute pulmonary oedema | 10.45 | 10.32 | 35 | 540241 | 8123 | 62940623 |
International normalised ratio fluctuation | 10.44 | 10.32 | 4 | 540272 | 2474 | 62946272 |
Drug effective for unapproved indication | 10.43 | 10.32 | 8 | 540268 | 3356 | 62945390 |
Forceps delivery | 10.35 | 10.32 | 11 | 540265 | 209 | 62948537 |
Post-traumatic stress disorder | 10.32 | 10.32 | 18 | 540258 | 5233 | 62943513 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Rheumatoid arthritis | 507.39 | 10.27 | 832 | 196495 | 37406 | 34722198 |
Drug abuse | 379.79 | 10.27 | 54 | 197273 | 99042 | 34660562 |
Completed suicide | 302.93 | 10.27 | 89 | 197238 | 98079 | 34661525 |
Toxicity to various agents | 264.70 | 10.27 | 453 | 196874 | 199909 | 34559695 |
Foetal exposure during pregnancy | 240.34 | 10.27 | 609 | 196718 | 37492 | 34722112 |
Arthralgia | 214.87 | 10.27 | 1668 | 195659 | 168373 | 34591231 |
Psoriatic arthropathy | 180.11 | 10.27 | 366 | 196961 | 19432 | 34740172 |
Drug interaction | 145.68 | 10.27 | 718 | 196609 | 225228 | 34534376 |
Sickle cell anaemia with crisis | 132.91 | 10.27 | 138 | 197189 | 3915 | 34755689 |
Joint swelling | 124.60 | 10.27 | 667 | 196660 | 59223 | 34700381 |
Dysmorphism | 121.05 | 10.27 | 117 | 197210 | 3039 | 34756565 |
Psoriasis | 111.83 | 10.27 | 475 | 196852 | 38337 | 34721267 |
Musculoskeletal stiffness | 96.47 | 10.27 | 519 | 196808 | 46161 | 34713443 |
Intentional overdose | 88.48 | 10.27 | 70 | 197257 | 43604 | 34716000 |
Product use in unapproved indication | 85.99 | 10.27 | 356 | 196971 | 117143 | 34642461 |
Premature baby | 79.54 | 10.27 | 268 | 197059 | 19365 | 34740239 |
Enthesopathy | 76.00 | 10.27 | 111 | 197216 | 4502 | 34755102 |
Blood pressure fluctuation | 75.83 | 10.27 | 313 | 197014 | 24936 | 34734668 |
Death | 74.64 | 10.27 | 1696 | 195631 | 396353 | 34363251 |
Acute kidney injury | 72.03 | 10.27 | 1250 | 196077 | 303738 | 34455866 |
Tenosynovitis | 71.03 | 10.27 | 107 | 197220 | 4463 | 34755141 |
Synovitis | 70.79 | 10.27 | 207 | 197120 | 13859 | 34745745 |
Exposure during pregnancy | 69.50 | 10.27 | 155 | 197172 | 8779 | 34750825 |
Pain | 69.12 | 10.27 | 1576 | 195751 | 203099 | 34556505 |
Hepatic function abnormal | 68.39 | 10.27 | 90 | 197237 | 44273 | 34715331 |
Speech disorder developmental | 66.97 | 10.27 | 72 | 197255 | 2128 | 34757476 |
C-reactive protein abnormal | 62.10 | 10.27 | 146 | 197181 | 8564 | 34751040 |
Febrile neutropenia | 60.56 | 10.27 | 488 | 196839 | 136361 | 34623243 |
Arthropathy | 60.29 | 10.27 | 306 | 197021 | 26601 | 34733003 |
Foetal anticonvulsant syndrome | 57.20 | 10.27 | 50 | 197277 | 1137 | 34758467 |
Drug resistance | 57.14 | 10.27 | 38 | 197289 | 25889 | 34733715 |
Drug dependence | 55.42 | 10.27 | 34 | 197293 | 24183 | 34735421 |
Neonatal respiratory distress syndrome | 55.10 | 10.27 | 89 | 197238 | 3945 | 34755659 |
Blood pressure systolic increased | 54.95 | 10.27 | 266 | 197061 | 22686 | 34736918 |
Suicide attempt | 54.71 | 10.27 | 85 | 197242 | 39031 | 34720573 |
Maternal exposure during pregnancy | 54.65 | 10.27 | 99 | 197228 | 4819 | 34754785 |
Intentional product misuse | 53.98 | 10.27 | 110 | 197217 | 45501 | 34714103 |
Rhabdomyolysis | 53.34 | 10.27 | 201 | 197126 | 67962 | 34691642 |
Sopor | 53.15 | 10.27 | 4 | 197323 | 12132 | 34747472 |
Alanine aminotransferase abnormal | 52.90 | 10.27 | 95 | 197232 | 4593 | 34755011 |
Overdose | 52.59 | 10.27 | 300 | 197027 | 90759 | 34668845 |
Coma | 51.68 | 10.27 | 113 | 197214 | 45565 | 34714039 |
Hypospadias | 51.25 | 10.27 | 76 | 197251 | 3125 | 34756479 |
Multiple organ dysfunction syndrome | 51.12 | 10.27 | 240 | 197087 | 76326 | 34683278 |
Disease progression | 50.79 | 10.27 | 379 | 196948 | 107698 | 34651906 |
Atrial septal defect | 49.57 | 10.27 | 121 | 197206 | 7271 | 34752333 |
Arthritis | 47.79 | 10.27 | 322 | 197005 | 31024 | 34728580 |
Nasopharyngitis | 46.80 | 10.27 | 602 | 196725 | 69366 | 34690238 |
Learning disorder | 46.73 | 10.27 | 43 | 197284 | 1048 | 34758556 |
Autism spectrum disorder | 46.45 | 10.27 | 61 | 197266 | 2235 | 34757369 |
Cardiac failure | 46.27 | 10.27 | 313 | 197014 | 90935 | 34668669 |
Cryptorchism | 45.66 | 10.27 | 57 | 197270 | 1984 | 34757620 |
Maternal drugs affecting foetus | 45.57 | 10.27 | 81 | 197246 | 3884 | 34755720 |
Low birth weight baby | 45.34 | 10.27 | 122 | 197205 | 7783 | 34751821 |
Off label use | 45.25 | 10.27 | 1923 | 195404 | 417601 | 34342003 |
Peripheral swelling | 44.82 | 10.27 | 643 | 196684 | 75898 | 34683706 |
Hypoglycaemia neonatal | 43.99 | 10.27 | 54 | 197273 | 1847 | 34757757 |
Cytomegalovirus infection | 43.45 | 10.27 | 50 | 197277 | 26085 | 34733519 |
Lower respiratory tract infection | 42.40 | 10.27 | 315 | 197012 | 31322 | 34728282 |
Small for dates baby | 41.05 | 10.27 | 77 | 197250 | 3850 | 34755754 |
Blood pressure systolic abnormal | 40.76 | 10.27 | 77 | 197250 | 3871 | 34755733 |
Rheumatoid nodule | 40.23 | 10.27 | 65 | 197262 | 2882 | 34756722 |
Ventricular septal defect | 40.03 | 10.27 | 77 | 197250 | 3924 | 34755680 |
Tongue disorder | 39.71 | 10.27 | 91 | 197236 | 5248 | 34754356 |
Poisoning | 39.71 | 10.27 | 10 | 197317 | 12216 | 34747388 |
Maternal exposure during breast feeding | 39.31 | 10.27 | 46 | 197281 | 1495 | 34758109 |
Syndactyly | 38.37 | 10.27 | 35 | 197292 | 843 | 34758761 |
Haemoglobin decreased | 38.24 | 10.27 | 922 | 196405 | 119850 | 34639754 |
Drug reaction with eosinophilia and systemic symptoms | 36.25 | 10.27 | 83 | 197244 | 32929 | 34726675 |
Osteoarthritis | 35.74 | 10.27 | 219 | 197108 | 20423 | 34739181 |
Immune reconstitution inflammatory syndrome | 35.39 | 10.27 | 4 | 197323 | 8755 | 34750849 |
Pain in extremity | 34.82 | 10.27 | 948 | 196379 | 125565 | 34634039 |
Joint effusion | 34.81 | 10.27 | 85 | 197242 | 5108 | 34754496 |
Renal failure | 34.72 | 10.27 | 523 | 196804 | 130034 | 34629570 |
Blood pressure diastolic abnormal | 34.60 | 10.27 | 81 | 197246 | 4737 | 34754867 |
Respiratory arrest | 34.58 | 10.27 | 66 | 197261 | 27977 | 34731627 |
Appendicolith | 34.57 | 10.27 | 4 | 197323 | 8597 | 34751007 |
Hand deformity | 34.03 | 10.27 | 69 | 197258 | 3656 | 34755948 |
Developmental delay | 33.59 | 10.27 | 58 | 197269 | 2717 | 34756887 |
Heart rate decreased | 33.31 | 10.27 | 299 | 197028 | 31446 | 34728158 |
Blood pressure diastolic decreased | 33.24 | 10.27 | 120 | 197207 | 8974 | 34750630 |
Poisoning deliberate | 33.21 | 10.27 | 3 | 197324 | 7841 | 34751763 |
Renal impairment | 33.17 | 10.27 | 357 | 196970 | 94156 | 34665448 |
Somnolence | 32.76 | 10.27 | 436 | 196891 | 110680 | 34648924 |
Pathogen resistance | 32.29 | 10.27 | 7 | 197320 | 9475 | 34750129 |
Foot deformity | 32.28 | 10.27 | 76 | 197251 | 4461 | 34755143 |
Tendonitis | 32.06 | 10.27 | 119 | 197208 | 9021 | 34750583 |
Joint laxity | 32.03 | 10.27 | 23 | 197304 | 389 | 34759215 |
Grip strength decreased | 31.72 | 10.27 | 61 | 197266 | 3108 | 34756496 |
C-reactive protein increased | 31.47 | 10.27 | 454 | 196873 | 53644 | 34705960 |
Talipes | 31.28 | 10.27 | 46 | 197281 | 1877 | 34757727 |
Weight decreased | 31.23 | 10.27 | 1254 | 196073 | 175047 | 34584557 |
Exposure via breast milk | 31.15 | 10.27 | 47 | 197280 | 1963 | 34757641 |
Basal cell carcinoma | 29.99 | 10.27 | 202 | 197125 | 19456 | 34740148 |
Blood pressure increased | 28.90 | 10.27 | 676 | 196651 | 87426 | 34672178 |
Bradycardia | 28.88 | 10.27 | 279 | 197048 | 75139 | 34684465 |
Drug withdrawal syndrome | 28.79 | 10.27 | 42 | 197285 | 19792 | 34739812 |
Congenital hand malformation | 28.54 | 10.27 | 25 | 197302 | 570 | 34759034 |
Plagiocephaly | 28.27 | 10.27 | 24 | 197303 | 524 | 34759080 |
Depressed level of consciousness | 28.16 | 10.27 | 135 | 197192 | 42706 | 34716898 |
Altered state of consciousness | 28.12 | 10.27 | 54 | 197273 | 22839 | 34736765 |
Acute hepatic failure | 27.94 | 10.27 | 23 | 197304 | 14051 | 34745553 |
Knee arthroplasty | 27.87 | 10.27 | 99 | 197228 | 7345 | 34752259 |
Hypermobility syndrome | 27.52 | 10.27 | 20 | 197307 | 345 | 34759259 |
Pulmonary fibrosis | 27.45 | 10.27 | 188 | 197139 | 18208 | 34741396 |
Infusion related reaction | 26.90 | 10.27 | 435 | 196892 | 52622 | 34706982 |
Fall | 26.81 | 10.27 | 1401 | 195926 | 201484 | 34558120 |
Drug intolerance | 26.79 | 10.27 | 479 | 196848 | 59091 | 34700513 |
Suicidal ideation | 26.70 | 10.27 | 127 | 197200 | 40261 | 34719343 |
Dysgraphia | 26.64 | 10.27 | 47 | 197280 | 2240 | 34757364 |
Shock | 26.38 | 10.27 | 61 | 197266 | 24118 | 34735486 |
Red blood cell sedimentation rate increased | 26.27 | 10.27 | 112 | 197215 | 9050 | 34750554 |
Intellectual disability | 26.23 | 10.27 | 35 | 197292 | 1303 | 34758301 |
Jaundice neonatal | 26.06 | 10.27 | 35 | 197292 | 1311 | 34758293 |
Colitis ulcerative | 25.95 | 10.27 | 171 | 197156 | 16349 | 34743255 |
Palmar-plantar erythrodysaesthesia syndrome | 25.95 | 10.27 | 34 | 197293 | 16761 | 34742843 |
Caesarean section | 25.90 | 10.27 | 45 | 197282 | 2119 | 34757485 |
Finger deformity | 25.79 | 10.27 | 37 | 197290 | 1476 | 34758128 |
Body temperature decreased | 25.62 | 10.27 | 143 | 197184 | 12891 | 34746713 |
Substance abuse | 25.30 | 10.27 | 6 | 197321 | 7635 | 34751969 |
Musculoskeletal pain | 25.29 | 10.27 | 284 | 197043 | 31679 | 34727925 |
Astigmatism | 25.13 | 10.27 | 31 | 197296 | 1066 | 34758538 |
Acute chest syndrome | 25.06 | 10.27 | 27 | 197300 | 800 | 34758804 |
Venoocclusive liver disease | 24.95 | 10.27 | 7 | 197320 | 7959 | 34751645 |
Psychotic disorder | 24.85 | 10.27 | 64 | 197263 | 24388 | 34735216 |
Pancytopenia | 24.75 | 10.27 | 708 | 196619 | 94449 | 34665155 |
Malignant neoplasm progression | 24.68 | 10.27 | 349 | 196978 | 87697 | 34671907 |
Language disorder | 24.54 | 10.27 | 45 | 197282 | 2211 | 34757393 |
Hypoglycaemia | 24.52 | 10.27 | 194 | 197133 | 54446 | 34705158 |
Diaphragmatic disorder | 24.45 | 10.27 | 33 | 197294 | 1242 | 34758362 |
Angioedema | 24.43 | 10.27 | 118 | 197209 | 37256 | 34722348 |
Large for dates baby | 24.42 | 10.27 | 28 | 197299 | 890 | 34758714 |
Foetal growth restriction | 24.08 | 10.27 | 64 | 197263 | 4053 | 34755551 |
Wound | 24.05 | 10.27 | 155 | 197172 | 14709 | 34744895 |
Polyarthritis | 23.99 | 10.27 | 68 | 197259 | 4472 | 34755132 |
Anal fistula | 23.93 | 10.27 | 76 | 197251 | 5323 | 34754281 |
Rash maculo-papular | 23.50 | 10.27 | 82 | 197245 | 28369 | 34731235 |
Hyperglycaemia | 23.35 | 10.27 | 129 | 197198 | 39351 | 34720253 |
Mobility decreased | 23.07 | 10.27 | 266 | 197061 | 29862 | 34729742 |
Cardiogenic shock | 22.47 | 10.27 | 76 | 197251 | 26542 | 34733062 |
Tuberculosis | 22.43 | 10.27 | 102 | 197225 | 8475 | 34751129 |
Hydrops foetalis | 22.32 | 10.27 | 26 | 197301 | 841 | 34758763 |
Wrong technique in product usage process | 22.16 | 10.27 | 116 | 197211 | 35870 | 34723734 |
Ultrasound antenatal screen | 22.06 | 10.27 | 21 | 197306 | 535 | 34759069 |
No adverse event | 21.80 | 10.27 | 62 | 197265 | 22865 | 34736739 |
Inflammation | 21.75 | 10.27 | 250 | 197077 | 28045 | 34731559 |
Cardiac arrest | 21.67 | 10.27 | 397 | 196930 | 95762 | 34663842 |
Hypotonia neonatal | 21.63 | 10.27 | 32 | 197295 | 1313 | 34758291 |
Blood pressure diastolic increased | 21.60 | 10.27 | 70 | 197257 | 4955 | 34754649 |
Neck pain | 21.33 | 10.27 | 228 | 197099 | 25121 | 34734483 |
Selective eating disorder | 21.31 | 10.27 | 37 | 197290 | 1741 | 34757863 |
Ventricular fibrillation | 21.15 | 10.27 | 63 | 197264 | 22891 | 34736713 |
Hyperbilirubinaemia neonatal | 21.05 | 10.27 | 24 | 197303 | 758 | 34758846 |
Aspergillus infection | 20.85 | 10.27 | 23 | 197304 | 12231 | 34747373 |
Neurotoxicity | 20.82 | 10.27 | 44 | 197283 | 17966 | 34741638 |
Sedation | 20.58 | 10.27 | 56 | 197271 | 20950 | 34738654 |
Motor developmental delay | 20.57 | 10.27 | 22 | 197305 | 646 | 34758958 |
Knee deformity | 20.57 | 10.27 | 22 | 197305 | 646 | 34758958 |
Ankylosing spondylitis | 20.53 | 10.27 | 74 | 197253 | 5530 | 34754074 |
Pyrexia | 20.39 | 10.27 | 1611 | 195716 | 331402 | 34428202 |
Fatigue | 20.34 | 10.27 | 2389 | 194938 | 368264 | 34391340 |
Otitis media | 20.32 | 10.27 | 48 | 197279 | 2824 | 34756780 |
Dyspraxia | 20.24 | 10.27 | 18 | 197309 | 419 | 34759185 |
Haematocrit decreased | 20.19 | 10.27 | 274 | 197053 | 31942 | 34727662 |
Encephalitis toxic | 19.96 | 10.27 | 15 | 197312 | 273 | 34759331 |
Vitamin D deficiency | 19.90 | 10.27 | 82 | 197245 | 6526 | 34753078 |
Serum ferritin increased | 19.89 | 10.27 | 78 | 197249 | 6068 | 34753536 |
Joint stiffness | 19.87 | 10.27 | 117 | 197210 | 10756 | 34748848 |
Radiation inflammation | 19.81 | 10.27 | 25 | 197302 | 880 | 34758724 |
Trisomy 18 | 19.64 | 10.27 | 23 | 197304 | 748 | 34758856 |
Sleep disorder due to a general medical condition | 19.62 | 10.27 | 3 | 197324 | 5218 | 34754386 |
Skin cancer | 19.59 | 10.27 | 112 | 197215 | 10185 | 34749419 |
Aptyalism | 19.58 | 10.27 | 17 | 197310 | 383 | 34759221 |
Lactic acidosis | 19.29 | 10.27 | 116 | 197211 | 34656 | 34724948 |
Ear infection | 19.28 | 10.27 | 111 | 197216 | 10120 | 34749484 |
Nasal disorder | 19.16 | 10.27 | 37 | 197290 | 1891 | 34757713 |
Incorrect route of product administration | 19.14 | 10.27 | 34 | 197293 | 14811 | 34744793 |
Drug withdrawal syndrome neonatal | 18.92 | 10.27 | 54 | 197273 | 3565 | 34756039 |
Osteonecrosis of jaw | 18.82 | 10.27 | 46 | 197281 | 17843 | 34741761 |
Ear disorder | 18.75 | 10.27 | 34 | 197293 | 1656 | 34757948 |
Disseminated intravascular coagulation | 18.61 | 10.27 | 62 | 197265 | 21754 | 34737850 |
Neck mass | 18.60 | 10.27 | 33 | 197294 | 1580 | 34758024 |
Post procedural infection | 18.54 | 10.27 | 65 | 197262 | 4791 | 34754813 |
Drug ineffective for unapproved indication | 18.49 | 10.27 | 70 | 197257 | 23645 | 34735959 |
Foetal disorder | 18.37 | 10.27 | 23 | 197304 | 803 | 34758801 |
Hydrocele | 18.29 | 10.27 | 38 | 197289 | 2049 | 34757555 |
Second primary malignancy | 18.14 | 10.27 | 11 | 197316 | 7875 | 34751729 |
Congenital foot malformation | 18.12 | 10.27 | 17 | 197310 | 425 | 34759179 |
Cleft lip and palate | 18.10 | 10.27 | 24 | 197303 | 888 | 34758716 |
Back disorder | 18.07 | 10.27 | 80 | 197247 | 6571 | 34753033 |
Dyslexia | 18.00 | 10.27 | 15 | 197312 | 319 | 34759285 |
Cleft lip | 17.88 | 10.27 | 15 | 197312 | 322 | 34759282 |
Arthritis infective | 17.86 | 10.27 | 51 | 197276 | 3368 | 34756236 |
Vomiting | 17.71 | 10.27 | 1182 | 196145 | 246439 | 34513165 |
Joint range of motion decreased | 17.68 | 10.27 | 85 | 197242 | 7227 | 34752377 |
Limb reduction defect | 17.64 | 10.27 | 14 | 197313 | 277 | 34759327 |
Oropharyngeal pain | 17.64 | 10.27 | 290 | 197037 | 35195 | 34724409 |
Agranulocytosis | 17.50 | 10.27 | 72 | 197255 | 23749 | 34735855 |
Serotonin syndrome | 17.45 | 10.27 | 56 | 197271 | 19877 | 34739727 |
Malignant melanoma | 17.42 | 10.27 | 91 | 197236 | 7999 | 34751605 |
Umbilical hernia | 17.34 | 10.27 | 62 | 197265 | 4615 | 34754989 |
Red blood cell sedimentation rate | 17.31 | 10.27 | 27 | 197300 | 1161 | 34758443 |
Suspected suicide | 17.23 | 10.27 | 3 | 197324 | 4745 | 34754859 |
Respiratory disorder neonatal | 17.09 | 10.27 | 32 | 197295 | 1598 | 34758006 |
Poor venous access | 16.95 | 10.27 | 66 | 197261 | 5117 | 34754487 |
Strabismus | 16.94 | 10.27 | 33 | 197294 | 1698 | 34757906 |
Respiratory failure | 16.87 | 10.27 | 475 | 196852 | 108097 | 34651507 |
Haematochezia | 16.80 | 10.27 | 362 | 196965 | 46172 | 34713432 |
Crohn's disease | 16.78 | 10.27 | 47 | 197280 | 3070 | 34756534 |
Blood parathyroid hormone decreased | 16.71 | 10.27 | 30 | 197297 | 1450 | 34758154 |
Arthritis bacterial | 16.69 | 10.27 | 65 | 197262 | 5041 | 34754563 |
Acute graft versus host disease | 16.52 | 10.27 | 8 | 197319 | 6495 | 34753109 |
Decreased gait velocity | 16.50 | 10.27 | 11 | 197316 | 164 | 34759440 |
Medical device implantation | 16.49 | 10.27 | 19 | 197308 | 607 | 34758997 |
Infection | 16.38 | 10.27 | 648 | 196679 | 90267 | 34669337 |
Multiple congenital abnormalities | 16.37 | 10.27 | 18 | 197309 | 546 | 34759058 |
Kidney infection | 16.29 | 10.27 | 67 | 197260 | 5327 | 34754277 |
Influenza | 16.25 | 10.27 | 381 | 196946 | 49285 | 34710319 |
Therapeutic product effect decreased | 16.19 | 10.27 | 281 | 197046 | 34462 | 34725142 |
Localised infection | 16.13 | 10.27 | 161 | 197166 | 17426 | 34742178 |
Agitation neonatal | 16.10 | 10.27 | 25 | 197302 | 1071 | 34758533 |
Cellulitis | 16.06 | 10.27 | 402 | 196925 | 52549 | 34707055 |
Anal fissure | 16.01 | 10.27 | 57 | 197270 | 4233 | 34755371 |
Cystitis haemorrhagic | 16.00 | 10.27 | 6 | 197321 | 5673 | 34753931 |
Juvenile idiopathic arthritis | 15.99 | 10.27 | 34 | 197293 | 1863 | 34757741 |
Anaphylactic shock | 15.99 | 10.27 | 42 | 197285 | 15899 | 34743705 |
Cholestasis | 15.96 | 10.27 | 88 | 197239 | 26860 | 34732744 |
Gastrointestinal infection | 15.95 | 10.27 | 70 | 197257 | 5728 | 34753876 |
Hypertelorism | 15.90 | 10.27 | 18 | 197309 | 564 | 34759040 |
Lacrimal disorder | 15.88 | 10.27 | 14 | 197313 | 322 | 34759282 |
Congenital bladder anomaly | 15.85 | 10.27 | 13 | 197314 | 270 | 34759334 |
Granuloma skin | 15.83 | 10.27 | 27 | 197300 | 1252 | 34758352 |
Weight decrease neonatal | 15.78 | 10.27 | 14 | 197313 | 325 | 34759279 |
Sexual dysfunction | 15.64 | 10.27 | 8 | 197319 | 6295 | 34753309 |
Appendicitis | 15.64 | 10.27 | 38 | 197289 | 14769 | 34744835 |
Withdrawal syndrome | 15.63 | 10.27 | 29 | 197298 | 12426 | 34747178 |
Intentional self-injury | 15.62 | 10.27 | 34 | 197293 | 13737 | 34745867 |
Immunodeficiency | 15.60 | 10.27 | 67 | 197260 | 5431 | 34754173 |
Spinal disorder | 15.45 | 10.27 | 56 | 197271 | 4196 | 34755408 |
Pectus excavatum | 15.44 | 10.27 | 12 | 197315 | 230 | 34759374 |
Congenital anomaly | 15.42 | 10.27 | 28 | 197299 | 1365 | 34758239 |
Lung neoplasm malignant | 15.36 | 10.27 | 158 | 197169 | 17237 | 34742367 |
Hypertriglyceridaemia | 15.34 | 10.27 | 15 | 197312 | 8433 | 34751171 |
Skin injury | 15.31 | 10.27 | 38 | 197289 | 2307 | 34757297 |
Ankyloglossia congenital | 15.30 | 10.27 | 13 | 197314 | 284 | 34759320 |
Respiratory rate increased | 15.29 | 10.27 | 102 | 197225 | 9792 | 34749812 |
Neuroleptic malignant syndrome | 15.28 | 10.27 | 51 | 197276 | 17883 | 34741721 |
Proteinuria | 15.21 | 10.27 | 54 | 197273 | 18588 | 34741016 |
Akathisia | 15.19 | 10.27 | 14 | 197313 | 8095 | 34751509 |
Attention deficit hyperactivity disorder | 15.19 | 10.27 | 40 | 197287 | 2519 | 34757085 |
Joint injury | 15.05 | 10.27 | 96 | 197231 | 9077 | 34750527 |
Mastication disorder | 15.02 | 10.27 | 27 | 197300 | 1306 | 34758298 |
Renal aplasia | 14.96 | 10.27 | 20 | 197307 | 746 | 34758858 |
Acute generalised exanthematous pustulosis | 14.84 | 10.27 | 10 | 197317 | 6766 | 34752838 |
Erythrosis | 14.69 | 10.27 | 9 | 197318 | 115 | 34759489 |
Vitamin B12 deficiency | 14.57 | 10.27 | 53 | 197274 | 3978 | 34755626 |
Ventricular tachycardia | 14.57 | 10.27 | 89 | 197238 | 26490 | 34733114 |
Failure to anastomose | 14.46 | 10.27 | 11 | 197316 | 204 | 34759400 |
Sarcopenia | 14.35 | 10.27 | 15 | 197312 | 429 | 34759175 |
Cerebral haemorrhage | 14.33 | 10.27 | 127 | 197200 | 34810 | 34724794 |
Therapy partial responder | 14.32 | 10.27 | 20 | 197307 | 9596 | 34750008 |
Synovial cyst | 14.28 | 10.27 | 37 | 197290 | 2307 | 34757297 |
Cardiotoxicity | 14.27 | 10.27 | 7 | 197320 | 5641 | 34753963 |
Cerebral haemorrhage neonatal | 14.25 | 10.27 | 12 | 197315 | 259 | 34759345 |
Joint ankylosis | 14.22 | 10.27 | 29 | 197298 | 1543 | 34758061 |
Abdominal discomfort | 14.14 | 10.27 | 440 | 196887 | 59395 | 34700209 |
Neutropenia | 14.12 | 10.27 | 732 | 196595 | 156046 | 34603558 |
Haemangioma congenital | 14.12 | 10.27 | 16 | 197311 | 502 | 34759102 |
Adenovirus infection | 14.09 | 10.27 | 6 | 197321 | 5251 | 34754353 |
Microcephaly | 14.07 | 10.27 | 20 | 197307 | 791 | 34758813 |
Behaviour disorder | 14.06 | 10.27 | 60 | 197267 | 4850 | 34754754 |
Sinusitis | 13.97 | 10.27 | 319 | 197008 | 41083 | 34718521 |
Hepatic failure | 13.96 | 10.27 | 126 | 197201 | 34405 | 34725199 |
Stevens-Johnson syndrome | 13.90 | 10.27 | 56 | 197271 | 18583 | 34741021 |
Urticaria | 13.90 | 10.27 | 258 | 197069 | 62119 | 34697485 |
Transplant rejection | 13.85 | 10.27 | 23 | 197304 | 10288 | 34749316 |
Arthrodesis | 13.85 | 10.27 | 15 | 197312 | 447 | 34759157 |
Hyperthermia | 13.84 | 10.27 | 24 | 197303 | 10553 | 34749051 |
Abortion spontaneous | 13.80 | 10.27 | 14 | 197313 | 386 | 34759218 |
Aggression | 13.73 | 10.27 | 147 | 197180 | 38817 | 34720787 |
Drug ineffective | 13.67 | 10.27 | 2319 | 195008 | 454432 | 34305172 |
C-reactive protein decreased | 13.67 | 10.27 | 33 | 197294 | 1969 | 34757635 |
Oesophageal fibrosis | 13.59 | 10.27 | 10 | 197317 | 176 | 34759428 |
Posterior reversible encephalopathy syndrome | 13.56 | 10.27 | 22 | 197305 | 9932 | 34749672 |
Upper respiratory tract infection | 13.53 | 10.27 | 262 | 197065 | 32797 | 34726807 |
Product quality issue | 13.47 | 10.27 | 50 | 197277 | 16985 | 34742619 |
Hernia pain | 13.44 | 10.27 | 12 | 197315 | 281 | 34759323 |
Chronic graft versus host disease | 13.41 | 10.27 | 4 | 197323 | 4369 | 34755235 |
Latent tuberculosis | 13.35 | 10.27 | 26 | 197301 | 1337 | 34758267 |
Tooth malformation | 13.35 | 10.27 | 10 | 197317 | 181 | 34759423 |
Arnold-Chiari malformation | 13.34 | 10.27 | 13 | 197314 | 341 | 34759263 |
Anti-cyclic citrullinated peptide antibody positive | 13.25 | 10.27 | 31 | 197296 | 1812 | 34757792 |
Agitation | 13.23 | 10.27 | 236 | 197091 | 57163 | 34702441 |
BK virus infection | 13.20 | 10.27 | 8 | 197319 | 5730 | 34753874 |
Tachycardia | 13.13 | 10.27 | 371 | 196956 | 84401 | 34675203 |
Thrombotic microangiopathy | 13.12 | 10.27 | 25 | 197302 | 10605 | 34748999 |
Scoliosis | 13.01 | 10.27 | 40 | 197287 | 2753 | 34756851 |
Fistula discharge | 12.98 | 10.27 | 20 | 197307 | 851 | 34758753 |
Back pain | 12.97 | 10.27 | 825 | 196502 | 120964 | 34638640 |
Bronchopulmonary aspergillosis | 12.96 | 10.27 | 41 | 197286 | 14618 | 34744986 |
Progressive multifocal leukoencephalopathy | 12.91 | 10.27 | 22 | 197305 | 9742 | 34749862 |
Developmental coordination disorder | 12.90 | 10.27 | 10 | 197317 | 191 | 34759413 |
Patent ductus arteriosus | 12.89 | 10.27 | 45 | 197282 | 3309 | 34756295 |
Dysstasia | 12.86 | 10.27 | 115 | 197212 | 12080 | 34747524 |
Cardio-respiratory arrest | 12.82 | 10.27 | 227 | 197100 | 55046 | 34704558 |
Autoscopy | 12.74 | 10.27 | 11 | 197316 | 246 | 34759358 |
Blood test abnormal | 12.73 | 10.27 | 75 | 197252 | 6896 | 34752708 |
Bone cyst | 12.71 | 10.27 | 28 | 197299 | 1572 | 34758032 |
Injection site pain | 12.69 | 10.27 | 299 | 197028 | 38706 | 34720898 |
Hypertransaminasaemia | 12.65 | 10.27 | 8 | 197319 | 5598 | 34754006 |
Respiratory depression | 12.63 | 10.27 | 48 | 197279 | 16197 | 34743407 |
End stage renal disease | 12.63 | 10.27 | 19 | 197308 | 8842 | 34750762 |
Abdominal adhesions | 12.62 | 10.27 | 27 | 197300 | 1486 | 34758118 |
Bradycardia neonatal | 12.61 | 10.27 | 21 | 197306 | 955 | 34758649 |
Loss of personal independence in daily activities | 12.59 | 10.27 | 260 | 197067 | 32919 | 34726685 |
Asphyxia | 12.57 | 10.27 | 12 | 197315 | 6823 | 34752781 |
Septic arthritis staphylococcal | 12.50 | 10.27 | 15 | 197312 | 501 | 34759103 |
Maternal exposure timing unspecified | 12.48 | 10.27 | 13 | 197314 | 370 | 34759234 |
Foetal heart rate deceleration abnormality | 12.38 | 10.27 | 15 | 197312 | 506 | 34759098 |
Hepatitis E antibody positive | 12.37 | 10.27 | 11 | 197316 | 256 | 34759348 |
Diverticular perforation | 12.29 | 10.27 | 45 | 197282 | 3389 | 34756215 |
Communication disorder | 12.12 | 10.27 | 37 | 197290 | 2537 | 34757067 |
Nephrotic syndrome | 12.11 | 10.27 | 14 | 197313 | 7289 | 34752315 |
Alcoholic liver disease | 12.06 | 10.27 | 16 | 197311 | 592 | 34759012 |
Foetal distress syndrome | 12.04 | 10.27 | 22 | 197305 | 1078 | 34758526 |
Brain oedema | 11.98 | 10.27 | 39 | 197288 | 13782 | 34745822 |
Asthma | 11.97 | 10.27 | 169 | 197158 | 42487 | 34717117 |
Low set ears | 11.96 | 10.27 | 14 | 197313 | 455 | 34759149 |
Nerve compression | 11.76 | 10.27 | 43 | 197284 | 3236 | 34756368 |
Delirium | 11.75 | 10.27 | 176 | 197151 | 43815 | 34715789 |
Nail bed inflammation | 11.74 | 10.27 | 9 | 197318 | 169 | 34759435 |
Polydactyly | 11.72 | 10.27 | 23 | 197304 | 1190 | 34758414 |
Bronchiolitis | 11.68 | 10.27 | 42 | 197285 | 3134 | 34756470 |
Respiratory tract infection viral | 11.68 | 10.27 | 36 | 197291 | 2481 | 34757123 |
Panniculitis | 11.66 | 10.27 | 31 | 197296 | 1963 | 34757641 |
Hepatic enzyme increased | 11.64 | 10.27 | 296 | 197031 | 38784 | 34720820 |
Interstitial lung disease | 11.62 | 10.27 | 280 | 197047 | 65002 | 34694602 |
Haemangioma | 11.62 | 10.27 | 30 | 197297 | 1867 | 34757737 |
Drug level increased | 11.59 | 10.27 | 75 | 197252 | 22021 | 34737583 |
Nodule | 11.58 | 10.27 | 72 | 197255 | 6747 | 34752857 |
Maternal exposure before pregnancy | 11.56 | 10.27 | 18 | 197309 | 773 | 34758831 |
Cytomegalovirus chorioretinitis | 11.53 | 10.27 | 3 | 197324 | 3586 | 34756018 |
Cytomegalovirus viraemia | 11.52 | 10.27 | 15 | 197312 | 7415 | 34752189 |
Vascular insufficiency | 11.51 | 10.27 | 12 | 197315 | 342 | 34759262 |
Educational problem | 11.48 | 10.27 | 15 | 197312 | 547 | 34759057 |
Myelosuppression | 11.36 | 10.27 | 63 | 197264 | 19202 | 34740402 |
Blood insulin increased | 11.34 | 10.27 | 12 | 197315 | 348 | 34759256 |
Glycosylated haemoglobin increased | 11.34 | 10.27 | 30 | 197297 | 11330 | 34748274 |
Anal atresia | 11.34 | 10.27 | 11 | 197316 | 287 | 34759317 |
Hepatitis E virus test positive | 11.31 | 10.27 | 11 | 197316 | 288 | 34759316 |
Nephropathy toxic | 11.28 | 10.27 | 35 | 197292 | 12553 | 34747051 |
Neoplasm progression | 11.27 | 10.27 | 81 | 197246 | 23219 | 34736385 |
Oxygen saturation decreased | 11.23 | 10.27 | 390 | 196937 | 53428 | 34706176 |
Complications of transplanted kidney | 11.22 | 10.27 | 6 | 197321 | 4603 | 34755001 |
Obsessive-compulsive disorder | 11.16 | 10.27 | 9 | 197318 | 5555 | 34754049 |
Hepatic cirrhosis | 11.15 | 10.27 | 148 | 197179 | 17166 | 34742438 |
Endophthalmitis | 11.14 | 10.27 | 3 | 197324 | 3505 | 34756099 |
Blood creatine phosphokinase increased | 11.13 | 10.27 | 182 | 197145 | 44675 | 34714929 |
Chronic obstructive pulmonary disease | 11.10 | 10.27 | 358 | 196969 | 48560 | 34711044 |
Spina bifida | 11.10 | 10.27 | 12 | 197315 | 357 | 34759247 |
Haemolysis | 11.07 | 10.27 | 81 | 197246 | 8013 | 34751591 |
Abnormal behaviour | 11.04 | 10.27 | 89 | 197238 | 24880 | 34734724 |
Hepatic steatosis | 11.03 | 10.27 | 155 | 197172 | 18207 | 34741397 |
Weight increased | 10.98 | 10.27 | 636 | 196691 | 92397 | 34667207 |
Heart rate irregular | 10.98 | 10.27 | 137 | 197190 | 15670 | 34743934 |
Acute graft versus host disease in skin | 10.96 | 10.27 | 8 | 197319 | 5193 | 34754411 |
Nephrolithiasis | 10.96 | 10.27 | 236 | 197091 | 30097 | 34729507 |
Cholelithiasis | 10.94 | 10.27 | 174 | 197153 | 20974 | 34738630 |
Hypermetropia | 10.94 | 10.27 | 14 | 197313 | 500 | 34759104 |
Drug use disorder | 10.89 | 10.27 | 5 | 197322 | 4186 | 34755418 |
Ear malformation | 10.88 | 10.27 | 11 | 197316 | 302 | 34759302 |
Acute respiratory distress syndrome | 10.83 | 10.27 | 94 | 197233 | 25875 | 34733729 |
Nail pitting | 10.82 | 10.27 | 11 | 197316 | 304 | 34759300 |
Pulmonary alveolar haemorrhage | 10.81 | 10.27 | 16 | 197311 | 7496 | 34752108 |
Pleural fibrosis | 10.80 | 10.27 | 24 | 197303 | 1356 | 34758248 |
Gangrene neonatal | 10.77 | 10.27 | 9 | 197318 | 192 | 34759412 |
Inguinal hernia | 10.76 | 10.27 | 77 | 197250 | 7564 | 34752040 |
Psychomotor retardation | 10.76 | 10.27 | 45 | 197282 | 3605 | 34755999 |
Cerebral infarction | 10.74 | 10.27 | 101 | 197226 | 27354 | 34732250 |
Palindromic rheumatism | 10.73 | 10.27 | 9 | 197318 | 193 | 34759411 |
Nail bed bleeding | 10.73 | 10.27 | 12 | 197315 | 371 | 34759233 |
Cirrhosis alcoholic | 10.72 | 10.27 | 18 | 197309 | 824 | 34758780 |
Pleuritic pain | 10.71 | 10.27 | 44 | 197283 | 3497 | 34756107 |
Personality change | 10.71 | 10.27 | 8 | 197319 | 5131 | 34754473 |
Hepatitis | 10.66 | 10.27 | 85 | 197242 | 23819 | 34735785 |
Blood phosphorus increased | 10.58 | 10.27 | 17 | 197310 | 7704 | 34751900 |
Pharyngeal disorder | 10.55 | 10.27 | 17 | 197310 | 752 | 34758852 |
Necrotising fasciitis streptococcal | 10.53 | 10.27 | 8 | 197319 | 148 | 34759456 |
Scarlet fever | 10.52 | 10.27 | 7 | 197320 | 104 | 34759500 |
Rheumatoid lung | 10.51 | 10.27 | 19 | 197308 | 923 | 34758681 |
Blood albumin decreased | 10.47 | 10.27 | 120 | 197207 | 13452 | 34746152 |
Irritability | 10.46 | 10.27 | 89 | 197238 | 24601 | 34735003 |
Joint instability | 10.40 | 10.27 | 13 | 197314 | 453 | 34759151 |
Blood magnesium decreased | 10.40 | 10.27 | 67 | 197260 | 6356 | 34753248 |
Red blood cell sedimentation rate abnormal | 10.39 | 10.27 | 44 | 197283 | 3545 | 34756059 |
Haematotoxicity | 10.35 | 10.27 | 19 | 197308 | 8175 | 34751429 |
Melaena | 10.35 | 10.27 | 139 | 197188 | 35241 | 34724363 |
Rheumatoid vasculitis | 10.34 | 10.27 | 10 | 197317 | 260 | 34759344 |
Haemophagocytic lymphohistiocytosis | 10.31 | 10.27 | 38 | 197289 | 12935 | 34746669 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1190.55 | 10.08 | 163 | 563457 | 245604 | 78935164 |
Rheumatoid arthritis | 1153.30 | 10.08 | 3666 | 559954 | 204804 | 78975964 |
Toxicity to various agents | 934.64 | 10.08 | 961 | 562659 | 420579 | 78760189 |
Arthropathy | 911.98 | 10.08 | 3040 | 560580 | 174071 | 79006697 |
Pemphigus | 900.10 | 10.08 | 2099 | 561521 | 97483 | 79083285 |
Systemic lupus erythematosus | 885.86 | 10.08 | 2355 | 561265 | 118794 | 79061974 |
Joint swelling | 876.29 | 10.08 | 4199 | 559421 | 284447 | 78896321 |
Hand deformity | 866.59 | 10.08 | 2123 | 561497 | 101796 | 79078972 |
Synovitis | 832.39 | 10.08 | 2650 | 560970 | 148084 | 79032684 |
Glossodynia | 776.00 | 10.08 | 2029 | 561591 | 101308 | 79079460 |
Drug abuse | 757.37 | 10.08 | 121 | 563499 | 162570 | 79018198 |
Arthralgia | 691.85 | 10.08 | 6615 | 557005 | 565188 | 78615580 |
Anti-cyclic citrullinated peptide antibody positive | 665.03 | 10.08 | 1672 | 561948 | 81471 | 79099297 |
Wound | 650.79 | 10.08 | 2053 | 561567 | 114126 | 79066642 |
Maternal exposure during pregnancy | 616.95 | 10.08 | 2245 | 561375 | 134293 | 79046475 |
Pericarditis | 593.94 | 10.08 | 1853 | 561767 | 102383 | 79078385 |
Infusion related reaction | 571.89 | 10.08 | 3168 | 560452 | 227069 | 78953699 |
Abdominal discomfort | 546.75 | 10.08 | 3333 | 560287 | 247394 | 78933374 |
Pain | 505.62 | 10.08 | 7367 | 556253 | 696435 | 78484333 |
Discomfort | 496.18 | 10.08 | 1979 | 561641 | 123638 | 79057130 |
Swelling | 493.56 | 10.08 | 2914 | 560706 | 213797 | 78966971 |
Alopecia | 483.93 | 10.08 | 3043 | 560577 | 228312 | 78952456 |
Drug interaction | 482.13 | 10.08 | 1425 | 562195 | 413758 | 78767010 |
Therapeutic product effect decreased | 473.67 | 10.08 | 2352 | 561268 | 161511 | 79019257 |
Musculoskeletal stiffness | 424.96 | 10.08 | 2394 | 561226 | 172614 | 79008154 |
Duodenal ulcer perforation | 420.36 | 10.08 | 1223 | 562397 | 64988 | 79115780 |
Helicobacter infection | 416.39 | 10.08 | 1260 | 562360 | 68444 | 79112324 |
Contraindicated product administered | 411.32 | 10.08 | 2198 | 561422 | 155340 | 79025428 |
Rheumatoid factor positive | 398.99 | 10.08 | 1125 | 562495 | 58714 | 79122054 |
Death | 398.32 | 10.08 | 2361 | 561259 | 564153 | 78616615 |
Intentional overdose | 377.83 | 10.08 | 138 | 563482 | 105822 | 79074946 |
Drug intolerance | 362.12 | 10.08 | 3142 | 560478 | 260977 | 78919791 |
Nasopharyngitis | 361.62 | 10.08 | 3046 | 560574 | 250835 | 78929933 |
Psoriatic arthropathy | 361.02 | 10.08 | 1293 | 562327 | 76706 | 79104062 |
Hepatic enzyme increased | 347.53 | 10.08 | 2346 | 561274 | 180264 | 79000504 |
Febrile neutropenia | 318.22 | 10.08 | 727 | 562893 | 230272 | 78950496 |
Exposure during pregnancy | 300.89 | 10.08 | 1464 | 562156 | 99668 | 79081100 |
Impaired healing | 271.67 | 10.08 | 1284 | 562336 | 86371 | 79094397 |
Acute kidney injury | 263.29 | 10.08 | 2375 | 561245 | 517029 | 78663739 |
Hypersensitivity | 237.12 | 10.08 | 2865 | 560755 | 259374 | 78921394 |
Peripheral swelling | 234.88 | 10.08 | 2925 | 560695 | 266692 | 78914076 |
Depressed level of consciousness | 231.57 | 10.08 | 205 | 563415 | 96447 | 79084321 |
Muscle injury | 230.65 | 10.08 | 812 | 562808 | 47749 | 79133019 |
C-reactive protein abnormal | 229.94 | 10.08 | 809 | 562811 | 47558 | 79133210 |
Folliculitis | 227.81 | 10.08 | 884 | 562736 | 54496 | 79126272 |
Lower respiratory tract infection | 226.80 | 10.08 | 1628 | 561992 | 127592 | 79053176 |
Sinusitis | 221.21 | 10.08 | 2233 | 561387 | 193268 | 78987500 |
Irritable bowel syndrome | 220.77 | 10.08 | 949 | 562671 | 61292 | 79119476 |
Suicide attempt | 219.87 | 10.08 | 159 | 563461 | 82773 | 79097995 |
Treatment failure | 219.43 | 10.08 | 2001 | 561619 | 168485 | 79012283 |
Cardiac arrest | 210.90 | 10.08 | 575 | 563045 | 171521 | 79009247 |
Blister | 210.11 | 10.08 | 1506 | 562114 | 117970 | 79062798 |
Overdose | 209.26 | 10.08 | 638 | 562982 | 183568 | 78997200 |
Sickle cell anaemia with crisis | 202.98 | 10.08 | 265 | 563355 | 7657 | 79173111 |
Red blood cell sedimentation rate abnormal | 202.63 | 10.08 | 454 | 563166 | 20509 | 79160259 |
Sleep disorder due to general medical condition, insomnia type | 200.60 | 10.08 | 721 | 562899 | 42835 | 79137933 |
Knee arthroplasty | 195.02 | 10.08 | 711 | 562909 | 42537 | 79138231 |
Arthritis | 191.66 | 10.08 | 1430 | 562190 | 113450 | 79067318 |
Osteoarthritis | 186.35 | 10.08 | 1155 | 562465 | 86154 | 79094614 |
Product use issue | 182.93 | 10.08 | 2277 | 561343 | 207545 | 78973223 |
Hip arthroplasty | 180.36 | 10.08 | 610 | 563010 | 35146 | 79145622 |
Rhabdomyolysis | 177.40 | 10.08 | 284 | 563336 | 102847 | 79077921 |
Blood pressure fluctuation | 176.54 | 10.08 | 939 | 562681 | 66206 | 79114562 |
Weight increased | 173.70 | 10.08 | 2840 | 560780 | 274546 | 78906222 |
Malignant neoplasm progression | 171.41 | 10.08 | 448 | 563172 | 135542 | 79045226 |
Hepatic function abnormal | 165.76 | 10.08 | 163 | 563457 | 72944 | 79107824 |
Respiratory arrest | 163.75 | 10.08 | 102 | 563518 | 57448 | 79123320 |
Disease progression | 163.47 | 10.08 | 708 | 562912 | 183654 | 78997114 |
Cardiac failure | 161.46 | 10.08 | 557 | 563063 | 154285 | 79026483 |
Sopor | 159.40 | 10.08 | 22 | 563598 | 32988 | 79147780 |
Renal failure | 158.05 | 10.08 | 806 | 562814 | 200162 | 78980606 |
Neutropenia | 156.89 | 10.08 | 1290 | 562330 | 286420 | 78894348 |
Rheumatic fever | 151.31 | 10.08 | 495 | 563125 | 28030 | 79152738 |
Bradycardia | 150.73 | 10.08 | 474 | 563146 | 135083 | 79045685 |
Sedation | 149.01 | 10.08 | 91 | 563529 | 51804 | 79128964 |
Multiple organ dysfunction syndrome | 147.85 | 10.08 | 401 | 563219 | 119845 | 79060923 |
Drug reaction with eosinophilia and systemic symptoms | 147.09 | 10.08 | 142 | 563478 | 64102 | 79116666 |
Psoriasis | 144.25 | 10.08 | 1106 | 562514 | 88481 | 79092287 |
Lactic acidosis | 142.77 | 10.08 | 172 | 563448 | 70187 | 79110581 |
Drug resistance | 140.57 | 10.08 | 61 | 563559 | 42152 | 79138616 |
Contusion | 137.64 | 10.08 | 1633 | 561987 | 147143 | 79033625 |
Infection | 135.04 | 10.08 | 2430 | 561190 | 239282 | 78941486 |
Intentional product misuse | 134.60 | 10.08 | 295 | 563325 | 94870 | 79085898 |
Fibromyalgia | 132.20 | 10.08 | 843 | 562777 | 63497 | 79117271 |
Pregnancy | 131.84 | 10.08 | 454 | 563166 | 26397 | 79154371 |
Abortion spontaneous | 129.58 | 10.08 | 481 | 563139 | 29026 | 79151742 |
Blood pressure systolic increased | 129.31 | 10.08 | 864 | 562756 | 66122 | 79114646 |
Blood pressure systolic abnormal | 126.62 | 10.08 | 336 | 563284 | 16911 | 79163857 |
Swollen joint count increased | 126.26 | 10.08 | 403 | 563217 | 22524 | 79158244 |
Fatigue | 123.27 | 10.08 | 7876 | 555744 | 921851 | 78258917 |
Ill-defined disorder | 123.17 | 10.08 | 843 | 562777 | 65032 | 79115736 |
Cytomegalovirus infection | 122.13 | 10.08 | 75 | 563545 | 42569 | 79138199 |
Blood pressure diastolic abnormal | 122.11 | 10.08 | 355 | 563265 | 18847 | 79161921 |
Red blood cell sedimentation rate increased | 120.42 | 10.08 | 642 | 562978 | 45300 | 79135468 |
Cardio-respiratory arrest | 119.52 | 10.08 | 381 | 563239 | 108129 | 79072639 |
Poisoning deliberate | 118.71 | 10.08 | 3 | 563617 | 18825 | 79161943 |
Renal impairment | 118.33 | 10.08 | 643 | 562977 | 157140 | 79023628 |
Constipation | 117.99 | 10.08 | 1355 | 562265 | 281695 | 78899073 |
Somnolence | 114.64 | 10.08 | 1107 | 562513 | 237874 | 78942894 |
Condition aggravated | 114.61 | 10.08 | 4477 | 559143 | 496647 | 78684121 |
Joint effusion | 114.52 | 10.08 | 333 | 563287 | 17681 | 79163087 |
Hypoglycaemia | 113.10 | 10.08 | 355 | 563265 | 101239 | 79079529 |
Product use in unapproved indication | 112.51 | 10.08 | 1178 | 562442 | 249181 | 78931587 |
Neoplasm progression | 111.75 | 10.08 | 120 | 563500 | 51562 | 79129206 |
Coma | 111.13 | 10.08 | 353 | 563267 | 100296 | 79080472 |
Drug dependence | 109.57 | 10.08 | 77 | 563543 | 40692 | 79140076 |
Respiratory failure | 106.06 | 10.08 | 795 | 562825 | 180116 | 79000652 |
Poisoning | 104.48 | 10.08 | 25 | 563595 | 25247 | 79155521 |
Grip strength decreased | 104.10 | 10.08 | 366 | 563254 | 21503 | 79159265 |
Rash | 101.06 | 10.08 | 5026 | 558594 | 573332 | 78607436 |
Pain in extremity | 99.49 | 10.08 | 3323 | 560297 | 361215 | 78819553 |
Hypotension | 98.63 | 10.08 | 2364 | 561256 | 437953 | 78742815 |
Serotonin syndrome | 97.97 | 10.08 | 104 | 563516 | 44923 | 79135845 |
Hyperglycaemia | 96.22 | 10.08 | 222 | 563398 | 70113 | 79110655 |
Inflammation | 96.11 | 10.08 | 1050 | 562570 | 92703 | 79088065 |
C-reactive protein increased | 95.66 | 10.08 | 1360 | 562260 | 127667 | 79053101 |
Injection site erythema | 94.59 | 10.08 | 906 | 562714 | 77291 | 79103477 |
Intentional self-injury | 92.86 | 10.08 | 57 | 563563 | 32362 | 79148406 |
Agitation | 92.63 | 10.08 | 376 | 563244 | 99339 | 79081429 |
Thrombocytopenia | 92.28 | 10.08 | 1319 | 562301 | 263940 | 78916828 |
Osteoporosis | 91.57 | 10.08 | 676 | 562944 | 53436 | 79127332 |
Disseminated intravascular coagulation | 90.78 | 10.08 | 72 | 563548 | 35770 | 79144998 |
Tachycardia | 89.71 | 10.08 | 813 | 562807 | 176955 | 79003813 |
Blood pressure diastolic decreased | 89.50 | 10.08 | 437 | 563183 | 29779 | 79150989 |
Foot deformity | 89.17 | 10.08 | 372 | 563248 | 23702 | 79157066 |
Enthesopathy | 89.15 | 10.08 | 230 | 563390 | 11378 | 79169390 |
Altered state of consciousness | 89.04 | 10.08 | 107 | 563513 | 43715 | 79137053 |
Disability assessment scale score increased | 86.00 | 10.08 | 114 | 563506 | 3344 | 79177424 |
Rheumatoid nodule | 85.74 | 10.08 | 295 | 563325 | 17143 | 79163625 |
Musculoskeletal pain | 84.95 | 10.08 | 1101 | 562519 | 101253 | 79079515 |
Hepatic failure | 83.90 | 10.08 | 193 | 563427 | 61019 | 79119749 |
Stomatitis | 82.81 | 10.08 | 1478 | 562142 | 145279 | 79035489 |
Gastrointestinal disorder | 81.56 | 10.08 | 1265 | 562355 | 120940 | 79059828 |
Live birth | 79.35 | 10.08 | 302 | 563318 | 18442 | 79162326 |
Hyponatraemia | 78.57 | 10.08 | 840 | 562780 | 177008 | 79003760 |
Bone erosion | 78.42 | 10.08 | 291 | 563329 | 17556 | 79163212 |
Blood cholesterol increased | 77.85 | 10.08 | 920 | 562700 | 82800 | 79097968 |
Shock | 77.66 | 10.08 | 117 | 563503 | 43431 | 79137337 |
Injection site reaction | 77.64 | 10.08 | 657 | 562963 | 54128 | 79126640 |
Cholestasis | 77.47 | 10.08 | 157 | 563463 | 51952 | 79128816 |
Hyperhidrosis | 77.23 | 10.08 | 691 | 562929 | 150801 | 79029967 |
Juvenile idiopathic arthritis | 76.63 | 10.08 | 128 | 563492 | 4635 | 79176133 |
Heart rate decreased | 76.01 | 10.08 | 796 | 562824 | 69520 | 79111248 |
Tenosynovitis | 75.49 | 10.08 | 262 | 563358 | 15292 | 79165476 |
Sedation complication | 74.35 | 10.08 | 11 | 563609 | 15658 | 79165110 |
Angioedema | 72.97 | 10.08 | 283 | 563337 | 75752 | 79105016 |
Electrocardiogram QT prolonged | 71.86 | 10.08 | 361 | 563259 | 90025 | 79090743 |
Joint range of motion decreased | 71.43 | 10.08 | 441 | 563179 | 32841 | 79147927 |
Joint stiffness | 71.33 | 10.08 | 514 | 563106 | 40316 | 79140452 |
Ventricular tachycardia | 69.74 | 10.08 | 118 | 563502 | 41817 | 79138951 |
Respiratory depression | 69.35 | 10.08 | 56 | 563564 | 27574 | 79153194 |
Drug ineffective for unapproved indication | 69.06 | 10.08 | 163 | 563457 | 51075 | 79129693 |
Anaemia | 68.21 | 10.08 | 2515 | 561105 | 442500 | 78738268 |
Mobility decreased | 67.70 | 10.08 | 1227 | 562393 | 120948 | 79059820 |
Polyarthritis | 67.66 | 10.08 | 215 | 563405 | 11987 | 79168781 |
Syncope | 67.52 | 10.08 | 878 | 562742 | 178571 | 79002197 |
Injection site pruritus | 67.47 | 10.08 | 521 | 563099 | 41762 | 79139006 |
Joint destruction | 67.26 | 10.08 | 137 | 563483 | 5788 | 79174980 |
Anaphylactic shock | 66.84 | 10.08 | 94 | 563526 | 35902 | 79144866 |
Leukopenia | 66.84 | 10.08 | 515 | 563105 | 115998 | 79064770 |
Cerebral haemorrhage | 66.69 | 10.08 | 198 | 563422 | 57475 | 79123293 |
Hepatocellular injury | 66.08 | 10.08 | 149 | 563471 | 47444 | 79133324 |
Intentional product use issue | 66.07 | 10.08 | 1473 | 562147 | 150639 | 79030129 |
Cardiac failure congestive | 65.16 | 10.08 | 667 | 562953 | 141735 | 79039033 |
Metabolic acidosis | 64.82 | 10.08 | 331 | 563289 | 82198 | 79098570 |
Ventricular fibrillation | 64.81 | 10.08 | 78 | 563542 | 31848 | 79148920 |
Caesarean section | 64.22 | 10.08 | 215 | 563405 | 12320 | 79168448 |
Basal cell carcinoma | 62.15 | 10.08 | 465 | 563155 | 36910 | 79143858 |
Suspected suicide | 62.11 | 10.08 | 3 | 563617 | 10573 | 79170195 |
Palmar-plantar erythrodysaesthesia syndrome | 62.05 | 10.08 | 86 | 563534 | 33048 | 79147720 |
Neurotoxicity | 61.30 | 10.08 | 84 | 563536 | 32434 | 79148334 |
Drug withdrawal syndrome | 61.21 | 10.08 | 94 | 563526 | 34624 | 79146144 |
Myocardial infarction | 61.07 | 10.08 | 924 | 562696 | 183205 | 78997563 |
Localised infection | 60.52 | 10.08 | 464 | 563156 | 37111 | 79143657 |
Hyperkalaemia | 60.42 | 10.08 | 517 | 563103 | 113881 | 79066887 |
Injection site pain | 59.47 | 10.08 | 1267 | 562353 | 128571 | 79052197 |
Joint laxity | 59.42 | 10.08 | 78 | 563542 | 2266 | 79178502 |
Orthostatic hypotension | 59.21 | 10.08 | 201 | 563419 | 55963 | 79124805 |
Venoocclusive liver disease | 58.87 | 10.08 | 7 | 563613 | 11764 | 79169004 |
Pulmonary fibrosis | 58.85 | 10.08 | 522 | 563098 | 43590 | 79137178 |
Loss of personal independence in daily activities | 58.52 | 10.08 | 1035 | 562585 | 101545 | 79079223 |
Vomiting | 58.08 | 10.08 | 3989 | 559631 | 661839 | 78518929 |
Acute hepatic failure | 57.56 | 10.08 | 77 | 563543 | 30036 | 79150732 |
Hypoxia | 57.52 | 10.08 | 460 | 563160 | 102783 | 79077985 |
Cognitive disorder | 57.47 | 10.08 | 276 | 563344 | 69650 | 79111118 |
Drug ineffective | 56.42 | 10.08 | 8580 | 555040 | 1072333 | 78108435 |
Blood creatine phosphokinase increased | 56 | 10.08 | 258 | 563362 | 65832 | 79114936 |
Cardiogenic shock | 55.96 | 10.08 | 134 | 563486 | 41780 | 79138988 |
Tendonitis | 55.12 | 10.08 | 322 | 563298 | 23508 | 79157260 |
Aspergillus infection | 54.45 | 10.08 | 34 | 563586 | 19127 | 79161641 |
Blood pressure diastolic increased | 54.08 | 10.08 | 225 | 563395 | 14317 | 79166451 |
Agranulocytosis | 53.96 | 10.08 | 152 | 563468 | 44878 | 79135890 |
Gestational diabetes | 53.92 | 10.08 | 130 | 563490 | 6163 | 79174605 |
Mydriasis | 53.41 | 10.08 | 29 | 563591 | 17614 | 79163154 |
Immune reconstitution inflammatory syndrome | 52.86 | 10.08 | 16 | 563604 | 13825 | 79166943 |
Cerebral infarction | 52.68 | 10.08 | 157 | 563463 | 45519 | 79135249 |
Neutrophil count decreased | 52.64 | 10.08 | 418 | 563202 | 93541 | 79087227 |
Body temperature decreased | 52.36 | 10.08 | 398 | 563222 | 31747 | 79149021 |
Second primary malignancy | 52.31 | 10.08 | 18 | 563602 | 14332 | 79166436 |
Injection site swelling | 52.09 | 10.08 | 536 | 563084 | 46596 | 79134172 |
Nodule | 51.45 | 10.08 | 308 | 563312 | 22686 | 79158082 |
Disability | 50.99 | 10.08 | 248 | 563372 | 16872 | 79163896 |
Red blood cell sedimentation rate | 50.98 | 10.08 | 118 | 563502 | 5447 | 79175321 |
Creatinine renal clearance decreased | 50.92 | 10.08 | 36 | 563584 | 18966 | 79161802 |
Substance abuse | 50.86 | 10.08 | 7 | 563613 | 10519 | 79170249 |
Adverse event | 50.49 | 10.08 | 649 | 562971 | 59565 | 79121203 |
Type 2 diabetes mellitus | 49.74 | 10.08 | 620 | 563000 | 56502 | 79124266 |
No adverse event | 49.58 | 10.08 | 119 | 563501 | 37073 | 79143695 |
Tongue disorder | 49.47 | 10.08 | 213 | 563407 | 13762 | 79167006 |
Thrombotic microangiopathy | 49.24 | 10.08 | 42 | 563578 | 20127 | 79160641 |
Alanine aminotransferase abnormal | 48.95 | 10.08 | 156 | 563464 | 8711 | 79172057 |
Pathogen resistance | 48.91 | 10.08 | 20 | 563600 | 14322 | 79166446 |
Blood pressure increased | 48.32 | 10.08 | 1889 | 561731 | 209471 | 78971297 |
Abnormal behaviour | 48.18 | 10.08 | 117 | 563503 | 36304 | 79144464 |
Cytokine release syndrome | 48.13 | 10.08 | 115 | 563505 | 35883 | 79144885 |
Neuropathy peripheral | 47.91 | 10.08 | 706 | 562914 | 140599 | 79040169 |
Asphyxia | 47.66 | 10.08 | 12 | 563608 | 11708 | 79169060 |
Disturbance in attention | 47.52 | 10.08 | 191 | 563429 | 50610 | 79130158 |
Posterior reversible encephalopathy syndrome | 47.45 | 10.08 | 70 | 563550 | 26211 | 79154557 |
Torsade de pointes | 47.41 | 10.08 | 40 | 563580 | 19272 | 79161496 |
Myelosuppression | 46.84 | 10.08 | 138 | 563482 | 40158 | 79140610 |
Drug use disorder | 46.24 | 10.08 | 4 | 563616 | 8647 | 79172121 |
Wrong technique in product usage process | 45.99 | 10.08 | 319 | 563301 | 73556 | 79107212 |
Hallucination | 45.95 | 10.08 | 386 | 563234 | 85359 | 79095409 |
Ejection fraction decreased | 45.80 | 10.08 | 111 | 563509 | 34466 | 79146302 |
Bronchopulmonary aspergillosis | 45.75 | 10.08 | 54 | 563566 | 22240 | 79158528 |
Transplant rejection | 45.61 | 10.08 | 42 | 563578 | 19395 | 79161373 |
Appendicolith | 45.58 | 10.08 | 4 | 563616 | 8547 | 79172221 |
Neuroleptic malignant syndrome | 45.41 | 10.08 | 78 | 563542 | 27481 | 79153287 |
Osteonecrosis of jaw | 45.36 | 10.08 | 155 | 563465 | 43071 | 79137697 |
Femur fracture | 45.34 | 10.08 | 445 | 563175 | 38207 | 79142561 |
Psychotic disorder | 45.13 | 10.08 | 146 | 563474 | 41256 | 79139512 |
Tenderness | 45.04 | 10.08 | 304 | 563316 | 23338 | 79157430 |
Myalgia | 45.04 | 10.08 | 984 | 562636 | 184657 | 78996111 |
Brain oedema | 44.92 | 10.08 | 68 | 563552 | 25195 | 79155573 |
Haematotoxicity | 44.84 | 10.08 | 27 | 563593 | 15492 | 79165276 |
Restlessness | 44.63 | 10.08 | 173 | 563447 | 46319 | 79134449 |
Injection site bruising | 44.23 | 10.08 | 464 | 563156 | 40538 | 79140230 |
Acute graft versus host disease | 44.17 | 10.08 | 9 | 563611 | 10158 | 79170610 |
Ear infection | 44.16 | 10.08 | 404 | 563216 | 34028 | 79146740 |
Dyspnoea | 44.08 | 10.08 | 5345 | 558275 | 851680 | 78329088 |
Tremor | 44.05 | 10.08 | 892 | 562728 | 169191 | 79011577 |
Laryngitis | 44.00 | 10.08 | 227 | 563393 | 15812 | 79164956 |
Seizure | 43.80 | 10.08 | 1008 | 562612 | 187826 | 78992942 |
Sepsis | 43.41 | 10.08 | 1513 | 562107 | 267915 | 78912853 |
Drug level increased | 43.10 | 10.08 | 140 | 563480 | 39511 | 79141257 |
Unintentional medical device removal | 42.81 | 10.08 | 3 | 563617 | 7709 | 79173059 |
Disorientation | 42.66 | 10.08 | 264 | 563356 | 62512 | 79118256 |
Synovial cyst | 42.47 | 10.08 | 162 | 563458 | 9903 | 79170865 |
Withdrawal syndrome | 42.45 | 10.08 | 78 | 563542 | 26776 | 79153992 |
Oropharyngeal pain | 42.26 | 10.08 | 1042 | 562578 | 108311 | 79072457 |
Latent tuberculosis | 42.25 | 10.08 | 81 | 563539 | 3272 | 79177496 |
Nausea | 42.21 | 10.08 | 6028 | 557592 | 951168 | 78229600 |
Exposure to toxic agent | 42.16 | 10.08 | 7 | 563613 | 9151 | 79171617 |
Blood creatinine increased | 42.03 | 10.08 | 807 | 562813 | 154250 | 79026518 |
Blood glucose increased | 41.97 | 10.08 | 566 | 563054 | 114409 | 79066359 |
Encephalopathy | 41.97 | 10.08 | 291 | 563329 | 67106 | 79113662 |
Ascites | 41.93 | 10.08 | 337 | 563283 | 75225 | 79105543 |
Melaena | 41.93 | 10.08 | 255 | 563365 | 60635 | 79120133 |
Off label use | 41.90 | 10.08 | 5697 | 557923 | 901518 | 78279250 |
Exostosis | 41.76 | 10.08 | 232 | 563388 | 16626 | 79164142 |
Proteinuria | 41.75 | 10.08 | 106 | 563514 | 32396 | 79148372 |
Akathisia | 41.31 | 10.08 | 21 | 563599 | 13238 | 79167530 |
Hypokalaemia | 41.11 | 10.08 | 743 | 562877 | 143297 | 79037471 |
Acute respiratory distress syndrome | 41.02 | 10.08 | 166 | 563454 | 43901 | 79136867 |
Dehydration | 40.84 | 10.08 | 1390 | 562230 | 246797 | 78933971 |
Coronary artery disease | 40.62 | 10.08 | 283 | 563337 | 65191 | 79115577 |
Vision blurred | 40.23 | 10.08 | 517 | 563103 | 105381 | 79075387 |
Rash maculo-papular | 40.12 | 10.08 | 232 | 563388 | 55846 | 79124922 |
Neck mass | 39.92 | 10.08 | 93 | 563527 | 4311 | 79176457 |
Skin ulcer | 39.80 | 10.08 | 570 | 563050 | 53580 | 79127188 |
Aggression | 39.10 | 10.08 | 206 | 563414 | 50752 | 79130016 |
Fracture | 38.98 | 10.08 | 276 | 563344 | 21525 | 79159243 |
Suicidal ideation | 38.98 | 10.08 | 348 | 563272 | 75992 | 79104776 |
Hyperthermia | 38.86 | 10.08 | 42 | 563578 | 17995 | 79162773 |
Neck deformity | 38.84 | 10.08 | 56 | 563564 | 1781 | 79178987 |
Haemophagocytic lymphohistiocytosis | 38.61 | 10.08 | 59 | 563561 | 21778 | 79158990 |
Speech disorder | 38.55 | 10.08 | 226 | 563394 | 54219 | 79126549 |
Anaphylactic reaction | 38.40 | 10.08 | 392 | 563228 | 83351 | 79097417 |
Miosis | 38.39 | 10.08 | 33 | 563587 | 15756 | 79165012 |
Blood parathyroid hormone decreased | 38.39 | 10.08 | 162 | 563458 | 10374 | 79170394 |
Gamma-glutamyltransferase increased | 38.17 | 10.08 | 228 | 563392 | 54452 | 79126316 |
Acute chest syndrome | 38.11 | 10.08 | 51 | 563569 | 1510 | 79179258 |
Loss of consciousness | 37.96 | 10.08 | 900 | 562720 | 167043 | 79013725 |
Lupus-like syndrome | 37.93 | 10.08 | 196 | 563424 | 13661 | 79167107 |
Bursitis | 37.90 | 10.08 | 404 | 563216 | 35440 | 79145328 |
Joint injury | 37.85 | 10.08 | 363 | 563257 | 30972 | 79149796 |
Irritability | 37.66 | 10.08 | 156 | 563464 | 40988 | 79139780 |
Inappropriate antidiuretic hormone secretion | 37.66 | 10.08 | 81 | 563539 | 26232 | 79154536 |
Asthma | 37.57 | 10.08 | 700 | 562920 | 134395 | 79046373 |
Extrapyramidal disorder | 37.54 | 10.08 | 64 | 563556 | 22615 | 79158153 |
Ischaemic stroke | 37.40 | 10.08 | 115 | 563505 | 33016 | 79147752 |
Injection site rash | 37.34 | 10.08 | 236 | 563384 | 17718 | 79163050 |
Myoclonus | 37.27 | 10.08 | 88 | 563532 | 27572 | 79153196 |
Respiratory distress | 37.26 | 10.08 | 250 | 563370 | 58089 | 79122679 |
Tuberculosis | 36.88 | 10.08 | 208 | 563412 | 14990 | 79165778 |
Colorectal cancer | 36.85 | 10.08 | 8 | 563612 | 8639 | 79172129 |
Pyrexia | 36.74 | 10.08 | 4218 | 559402 | 674491 | 78506277 |
Eosinophilia | 36.67 | 10.08 | 180 | 563440 | 45165 | 79135603 |
Diabetic ketoacidosis | 36.04 | 10.08 | 122 | 563498 | 34000 | 79146768 |
Maternal exposure before pregnancy | 36.04 | 10.08 | 89 | 563531 | 4284 | 79176484 |
BK virus infection | 35.83 | 10.08 | 9 | 563611 | 8795 | 79171973 |
Wheelchair user | 35.80 | 10.08 | 110 | 563510 | 6022 | 79174746 |
Granuloma skin | 35.74 | 10.08 | 144 | 563476 | 9030 | 79171738 |
Arthritis infective | 35.62 | 10.08 | 134 | 563486 | 8137 | 79172631 |
Peripheral venous disease | 35.53 | 10.08 | 213 | 563407 | 15696 | 79165072 |
Multiple fractures | 35.37 | 10.08 | 131 | 563489 | 7895 | 79172873 |
Coagulopathy | 35.20 | 10.08 | 133 | 563487 | 35873 | 79144895 |
Acute generalised exanthematous pustulosis | 35.19 | 10.08 | 42 | 563578 | 17212 | 79163556 |
Facet joint syndrome | 34.58 | 10.08 | 165 | 563455 | 11137 | 79169631 |
Pre-eclampsia | 34.52 | 10.08 | 119 | 563501 | 6922 | 79173846 |
Stress cardiomyopathy | 34.32 | 10.08 | 18 | 563602 | 11148 | 79169620 |
Tachypnoea | 34.30 | 10.08 | 114 | 563506 | 31949 | 79148819 |
Pulmonary oedema | 34.22 | 10.08 | 429 | 563191 | 87825 | 79092943 |
Paradoxical drug reaction | 34.19 | 10.08 | 5 | 563615 | 7180 | 79173588 |
Anxiety | 34.18 | 10.08 | 1422 | 562198 | 247090 | 78933678 |
Disease recurrence | 34.01 | 10.08 | 178 | 563442 | 43931 | 79136837 |
Erythema multiforme | 33.87 | 10.08 | 45 | 563575 | 17606 | 79163162 |
Arrhythmia | 33.66 | 10.08 | 274 | 563346 | 60998 | 79119770 |
Ankylosing spondylitis | 33.66 | 10.08 | 173 | 563447 | 12032 | 79168736 |
Bronchospasm | 33.56 | 10.08 | 79 | 563541 | 24780 | 79155988 |
Lip dry | 33.52 | 10.08 | 205 | 563415 | 15213 | 79165555 |
Graft versus host disease | 33.48 | 10.08 | 34 | 563586 | 14992 | 79165776 |
Accidental overdose | 33.24 | 10.08 | 155 | 563465 | 39426 | 79141342 |
Atrial fibrillation | 33.08 | 10.08 | 1106 | 562514 | 196780 | 78983988 |
Clostridium difficile colitis | 33.04 | 10.08 | 117 | 563503 | 32166 | 79148602 |
Joint dislocation | 32.99 | 10.08 | 219 | 563401 | 16720 | 79164048 |
Smear cervix abnormal | 32.87 | 10.08 | 62 | 563558 | 2474 | 79178294 |
Limb deformity | 32.75 | 10.08 | 76 | 563544 | 3514 | 79177254 |
Hypothermia | 32.57 | 10.08 | 70 | 563550 | 22676 | 79158092 |
Premature labour | 32.14 | 10.08 | 131 | 563489 | 8259 | 79172509 |
Fear of injection | 32.12 | 10.08 | 121 | 563499 | 7353 | 79173415 |
Interstitial lung disease | 32.07 | 10.08 | 581 | 563039 | 112019 | 79068749 |
Maternal exposure timing unspecified | 32.06 | 10.08 | 102 | 563518 | 5690 | 79175078 |
Status epilepticus | 31.91 | 10.08 | 82 | 563538 | 24959 | 79155809 |
Panniculitis | 31.82 | 10.08 | 172 | 563448 | 12199 | 79168569 |
Therapeutic response decreased | 31.78 | 10.08 | 656 | 562964 | 66197 | 79114571 |
Forced expiratory volume decreased | 31.77 | 10.08 | 8 | 563612 | 7806 | 79172962 |
Cytopenia | 31.52 | 10.08 | 60 | 563560 | 20323 | 79160445 |
Pancreatitis acute | 31.47 | 10.08 | 213 | 563407 | 49391 | 79131377 |
Poor venous access | 31.42 | 10.08 | 228 | 563392 | 17921 | 79162847 |
Spinal stenosis | 31.26 | 10.08 | 205 | 563415 | 15586 | 79165182 |
Graft versus host disease in gastrointestinal tract | 31.25 | 10.08 | 4 | 563616 | 6352 | 79174416 |
Gastroenteritis viral | 31.16 | 10.08 | 290 | 563330 | 24541 | 79156227 |
Rotator cuff repair | 31.09 | 10.08 | 51 | 563569 | 1819 | 79178949 |
Chronic kidney disease | 31.02 | 10.08 | 308 | 563312 | 65846 | 79114922 |
Chest discomfort | 30.85 | 10.08 | 741 | 562879 | 137303 | 79043465 |
Premature rupture of membranes | 30.61 | 10.08 | 80 | 563540 | 3989 | 79176779 |
Anuria | 30.45 | 10.08 | 64 | 563556 | 20899 | 79159869 |
Asthenia | 30.43 | 10.08 | 3159 | 560461 | 508530 | 78672238 |
Blood calcium decreased | 30.16 | 10.08 | 119 | 563501 | 31700 | 79149068 |
Scleritis | 30.10 | 10.08 | 83 | 563537 | 4273 | 79176495 |
Adenovirus infection | 30.10 | 10.08 | 11 | 563609 | 8436 | 79172332 |
Retinitis | 29.99 | 10.08 | 98 | 563522 | 5545 | 79175223 |
Toxic skin eruption | 29.97 | 10.08 | 71 | 563549 | 22222 | 79158546 |
Premature delivery | 29.92 | 10.08 | 275 | 563345 | 23192 | 79157576 |
Mania | 29.80 | 10.08 | 52 | 563568 | 18208 | 79162560 |
Cytomegalovirus viraemia | 29.74 | 10.08 | 28 | 563592 | 12793 | 79167975 |
Malignant mediastinal neoplasm | 29.72 | 10.08 | 43 | 563577 | 1372 | 79179396 |
Hepatitis B reactivation | 29.66 | 10.08 | 4 | 563616 | 6104 | 79174664 |
Acute myeloid leukaemia | 29.60 | 10.08 | 115 | 563505 | 30770 | 79149998 |
Angina pectoris | 29.50 | 10.08 | 229 | 563391 | 51503 | 79129265 |
Ulcer | 29.47 | 10.08 | 333 | 563287 | 29639 | 79151129 |
Face oedema | 29.44 | 10.08 | 101 | 563519 | 28035 | 79152733 |
Deep vein thrombosis postoperative | 29.37 | 10.08 | 152 | 563468 | 10600 | 79170168 |
Dysarthria | 29.19 | 10.08 | 321 | 563299 | 67301 | 79113467 |
Haemoptysis | 29.15 | 10.08 | 254 | 563366 | 55745 | 79125023 |
Balance disorder | 29.13 | 10.08 | 507 | 563113 | 98350 | 79082418 |
Wound infection | 29.02 | 10.08 | 278 | 563342 | 23713 | 79157055 |
Platelet count decreased | 28.89 | 10.08 | 1104 | 562516 | 193560 | 78987208 |
Metastases to bone | 28.86 | 10.08 | 83 | 563537 | 24344 | 79156424 |
Adjustment disorder with depressed mood | 28.79 | 10.08 | 134 | 563486 | 8952 | 79171816 |
Pulmonary embolism | 28.78 | 10.08 | 959 | 562661 | 170695 | 79010073 |
Anti-cyclic citrullinated peptide antibody | 28.77 | 10.08 | 99 | 563521 | 5753 | 79175015 |
Bone disorder | 28.57 | 10.08 | 232 | 563388 | 18881 | 79161887 |
Product quality issue | 28.45 | 10.08 | 133 | 563487 | 33807 | 79146961 |
Skin papilloma | 28.44 | 10.08 | 99 | 563521 | 5787 | 79174981 |
Psychomotor hyperactivity | 28.40 | 10.08 | 47 | 563573 | 16802 | 79163966 |
Klebsiella infection | 28.25 | 10.08 | 42 | 563578 | 15678 | 79165090 |
Metastases to liver | 28.06 | 10.08 | 104 | 563516 | 28210 | 79152558 |
Tumour lysis syndrome | 27.81 | 10.08 | 82 | 563538 | 23857 | 79156911 |
Pulmonary alveolar haemorrhage | 27.79 | 10.08 | 24 | 563596 | 11433 | 79169335 |
Unresponsive to stimuli | 27.31 | 10.08 | 257 | 563363 | 55531 | 79125237 |
Foot fracture | 27.23 | 10.08 | 256 | 563364 | 21725 | 79159043 |
Blood pressure decreased | 27.15 | 10.08 | 517 | 563103 | 98949 | 79081819 |
Aphasia | 27.05 | 10.08 | 206 | 563414 | 46526 | 79134242 |
Weight decreased | 27.05 | 10.08 | 2887 | 560733 | 352311 | 78828457 |
Sciatica | 26.98 | 10.08 | 356 | 563264 | 32866 | 79147902 |
Nocardiosis | 26.92 | 10.08 | 4 | 563616 | 5675 | 79175093 |
Device difficult to use | 26.85 | 10.08 | 33 | 563587 | 13352 | 79167416 |
Tenosynovitis stenosans | 26.82 | 10.08 | 64 | 563556 | 3014 | 79177754 |
Haemorrhage intracranial | 26.75 | 10.08 | 95 | 563525 | 26098 | 79154670 |
Drug tolerance decreased | 26.62 | 10.08 | 170 | 563450 | 12808 | 79167960 |
Hypertransaminasaemia | 26.55 | 10.08 | 27 | 563593 | 11897 | 79168871 |
Pemphigoid | 26.49 | 10.08 | 42 | 563578 | 15273 | 79165495 |
Cystitis haemorrhagic | 26.44 | 10.08 | 16 | 563604 | 9156 | 79171612 |
Liver injury | 26.41 | 10.08 | 554 | 563066 | 56060 | 79124708 |
Sexual dysfunction | 26.19 | 10.08 | 11 | 563609 | 7752 | 79173016 |
Synovial fluid analysis | 26.14 | 10.08 | 54 | 563566 | 2305 | 79178463 |
Influenza | 25.87 | 10.08 | 1142 | 562478 | 128464 | 79052304 |
Temperature regulation disorder | 25.80 | 10.08 | 5 | 563615 | 5848 | 79174920 |
Cerebrovascular accident | 25.70 | 10.08 | 869 | 562751 | 154423 | 79026345 |
Emotional distress | 25.66 | 10.08 | 171 | 563449 | 39798 | 79140970 |
Chronic graft versus host disease | 25.61 | 10.08 | 8 | 563612 | 6773 | 79173995 |
Acute graft versus host disease in skin | 25.60 | 10.08 | 11 | 563609 | 7647 | 79173121 |
Delirium | 25.59 | 10.08 | 432 | 563188 | 84195 | 79096573 |
Dislocation of vertebra | 25.55 | 10.08 | 117 | 563503 | 7763 | 79173005 |
Accidental exposure to product | 25.52 | 10.08 | 124 | 563496 | 31198 | 79149570 |
Skin cancer | 25.50 | 10.08 | 188 | 563432 | 14852 | 79165916 |
Stevens-Johnson syndrome | 25.43 | 10.08 | 167 | 563453 | 38999 | 79141769 |
Dermatitis acneiform | 25.40 | 10.08 | 20 | 563600 | 9973 | 79170795 |
Acute myocardial infarction | 25.38 | 10.08 | 387 | 563233 | 76649 | 79104119 |
Shock haemorrhagic | 25.32 | 10.08 | 66 | 563554 | 19994 | 79160774 |
Blood bilirubin increased | 25.28 | 10.08 | 323 | 563297 | 65909 | 79114859 |
Labelled drug-drug interaction medication error | 25.21 | 10.08 | 105 | 563515 | 27545 | 79153223 |
Cyst | 25.20 | 10.08 | 176 | 563444 | 13664 | 79167104 |
Febrile bone marrow aplasia | 25.18 | 10.08 | 33 | 563587 | 12987 | 79167781 |
Breast cancer stage I | 25.13 | 10.08 | 8 | 563612 | 6692 | 79174076 |
Mental status changes | 25.02 | 10.08 | 328 | 563292 | 66631 | 79114137 |
Bradyphrenia | 24.96 | 10.08 | 23 | 563597 | 10617 | 79170151 |
Hyperuricaemia | 24.84 | 10.08 | 28 | 563592 | 11771 | 79168997 |
Lymphocyte count decreased | 24.83 | 10.08 | 214 | 563406 | 47075 | 79133693 |
Cardiotoxicity | 24.74 | 10.08 | 30 | 563590 | 12209 | 79168559 |
Rheumatoid lung | 24.64 | 10.08 | 76 | 563544 | 4169 | 79176599 |
Glycosylated haemoglobin increased | 24.59 | 10.08 | 63 | 563557 | 19197 | 79161571 |
Hepatotoxicity | 24.53 | 10.08 | 238 | 563382 | 51114 | 79129654 |
Haemoglobin decreased | 24.52 | 10.08 | 1855 | 561765 | 220264 | 78960504 |
White blood cell count decreased | 24.50 | 10.08 | 1084 | 562536 | 187204 | 78993564 |
Blood alkaline phosphatase increased | 24.48 | 10.08 | 310 | 563310 | 63354 | 79117414 |
Pulmonary arterial hypertension | 24.46 | 10.08 | 110 | 563510 | 28256 | 79152512 |
Oliguria | 24.36 | 10.08 | 49 | 563571 | 16260 | 79164508 |
Dystonia | 24.35 | 10.08 | 74 | 563546 | 21325 | 79159443 |
Fear | 24.33 | 10.08 | 77 | 563543 | 21909 | 79158859 |
Product administration error | 24.28 | 10.08 | 129 | 563491 | 31717 | 79149051 |
Ileus | 24.23 | 10.08 | 99 | 563521 | 26112 | 79154656 |
Herpes zoster | 24.17 | 10.08 | 844 | 562776 | 92239 | 79088529 |
Cardiac failure chronic | 23.91 | 10.08 | 26 | 563594 | 11109 | 79169659 |
Loose body in joint | 23.84 | 10.08 | 37 | 563583 | 1258 | 79179510 |
Multiple sclerosis relapse | 23.80 | 10.08 | 212 | 563408 | 46321 | 79134447 |
Malignant melanoma | 23.72 | 10.08 | 182 | 563438 | 14559 | 79166209 |
Gastrointestinal haemorrhage | 23.66 | 10.08 | 830 | 562790 | 146889 | 79033879 |
Obesity | 23.57 | 10.08 | 364 | 563256 | 34761 | 79146007 |
Mouth ulceration | 23.56 | 10.08 | 392 | 563228 | 38002 | 79142766 |
Urticaria | 23.53 | 10.08 | 1069 | 562551 | 184132 | 78996636 |
Diarrhoea | 23.50 | 10.08 | 5693 | 557927 | 874796 | 78305972 |
Antinuclear antibody positive | 23.28 | 10.08 | 114 | 563506 | 7776 | 79172992 |
Myocardial ischaemia | 23.20 | 10.08 | 97 | 563523 | 25422 | 79155346 |
Decreased appetite | 23.13 | 10.08 | 2094 | 561526 | 340324 | 78840444 |
Hemiplegia | 23.08 | 10.08 | 44 | 563576 | 14895 | 79165873 |
Fracture delayed union | 23.02 | 10.08 | 48 | 563572 | 2062 | 79178706 |
Nephropathy toxic | 22.96 | 10.08 | 71 | 563549 | 20348 | 79160420 |
Dyskinesia | 22.90 | 10.08 | 204 | 563416 | 44569 | 79136199 |
Synovial disorder | 22.69 | 10.08 | 46 | 563574 | 1937 | 79178831 |
Pancytopenia | 22.65 | 10.08 | 1409 | 562211 | 164336 | 79016432 |
Device use error | 22.49 | 10.08 | 11 | 563609 | 7090 | 79173678 |
Electrocardiogram QRS complex prolonged | 22.49 | 10.08 | 26 | 563594 | 10807 | 79169961 |
Infective pulmonary exacerbation of cystic fibrosis | 22.46 | 10.08 | 35 | 563585 | 12816 | 79167952 |
Immunodeficiency | 22.39 | 10.08 | 244 | 563376 | 21524 | 79159244 |
Hepatic cirrhosis | 22.39 | 10.08 | 359 | 563261 | 34547 | 79146221 |
Injection site warmth | 22.27 | 10.08 | 180 | 563440 | 14627 | 79166141 |
Therapy partial responder | 22.14 | 10.08 | 57 | 563563 | 17340 | 79163428 |
Metastases to central nervous system | 22.14 | 10.08 | 52 | 563568 | 16323 | 79164445 |
Vertigo | 22.09 | 10.08 | 349 | 563271 | 68733 | 79112035 |
Joint noise | 22.01 | 10.08 | 70 | 563550 | 3904 | 79176864 |
Blood lactic acid increased | 21.99 | 10.08 | 35 | 563585 | 12709 | 79168059 |
Affective disorder | 21.98 | 10.08 | 16 | 563604 | 8303 | 79172465 |
Pleural effusion | 21.95 | 10.08 | 822 | 562798 | 144440 | 79036328 |
Rhinorrhoea | 21.85 | 10.08 | 698 | 562922 | 75376 | 79105392 |
Hemiparesis | 21.82 | 10.08 | 144 | 563476 | 33589 | 79147179 |
Hyperbilirubinaemia | 21.80 | 10.08 | 94 | 563526 | 24424 | 79156344 |
Epstein-Barr virus infection | 21.80 | 10.08 | 43 | 563577 | 14373 | 79166395 |
Oral herpes | 21.80 | 10.08 | 293 | 563327 | 27161 | 79153607 |
Hyperthyroidism | 21.73 | 10.08 | 82 | 563538 | 22127 | 79158641 |
Pruritus genital | 21.63 | 10.08 | 3 | 563617 | 4483 | 79176285 |
Hallucination, visual | 21.53 | 10.08 | 139 | 563481 | 32590 | 79148178 |
Graft versus host disease in skin | 21.48 | 10.08 | 8 | 563612 | 6065 | 79174703 |
Hydrops foetalis | 21.47 | 10.08 | 27 | 563593 | 751 | 79180017 |
Finger deformity | 21.35 | 10.08 | 107 | 563513 | 7367 | 79173401 |
Polyneuropathy | 21.22 | 10.08 | 93 | 563527 | 24058 | 79156710 |
Sinus tachycardia | 21.22 | 10.08 | 163 | 563457 | 36745 | 79144023 |
Cardiac failure acute | 21.16 | 10.08 | 66 | 563554 | 18863 | 79161905 |
Haematocrit decreased | 20.99 | 10.08 | 575 | 563045 | 60737 | 79120031 |
Leukocytosis | 20.92 | 10.08 | 201 | 563419 | 43254 | 79137514 |
Cyanosis | 20.92 | 10.08 | 99 | 563521 | 25083 | 79155685 |
Multiple-drug resistance | 20.71 | 10.08 | 19 | 563601 | 8789 | 79171979 |
Ultrasound antenatal screen | 20.65 | 10.08 | 25 | 563595 | 668 | 79180100 |
Hyperprolactinaemia | 20.60 | 10.08 | 4 | 563616 | 4672 | 79176096 |
Haemodynamic instability | 20.58 | 10.08 | 59 | 563561 | 17323 | 79163445 |
Hyperammonaemia | 20.56 | 10.08 | 29 | 563591 | 11064 | 79169704 |
Hallucination, auditory | 20.51 | 10.08 | 76 | 563544 | 20617 | 79160151 |
Cleft lip and palate | 20.51 | 10.08 | 25 | 563595 | 673 | 79180095 |
Enterocolitis | 20.50 | 10.08 | 45 | 563575 | 14467 | 79166301 |
Bladder cancer | 20.49 | 10.08 | 70 | 563550 | 19456 | 79161312 |
Peripheral sensory neuropathy | 20.47 | 10.08 | 38 | 563582 | 12995 | 79167773 |
Anhedonia | 20.39 | 10.08 | 47 | 563573 | 14851 | 79165917 |
Endophthalmitis | 20.30 | 10.08 | 10 | 563610 | 6418 | 79174350 |
Transplant dysfunction | 20.26 | 10.08 | 13 | 563607 | 7208 | 79173560 |
Cytomegalovirus infection reactivation | 20.26 | 10.08 | 19 | 563601 | 8697 | 79172071 |
Pleuritic pain | 20.22 | 10.08 | 132 | 563488 | 10020 | 79170748 |
Septic shock | 20.12 | 10.08 | 688 | 562932 | 122113 | 79058655 |
Pancreatitis | 20.11 | 10.08 | 352 | 563268 | 68223 | 79112545 |
Bronchitis | 20.01 | 10.08 | 1122 | 562498 | 129522 | 79051246 |
Sinus bradycardia | 19.96 | 10.08 | 101 | 563519 | 25146 | 79155622 |
Palpitations | 19.91 | 10.08 | 713 | 562907 | 125897 | 79054871 |
Human antichimeric antibody positive | 19.89 | 10.08 | 39 | 563581 | 1602 | 79179166 |
Cytomegalovirus chorioretinitis | 19.82 | 10.08 | 7 | 563613 | 5483 | 79175285 |
Atrial tachycardia | 19.80 | 10.08 | 13 | 563607 | 7120 | 79173648 |
Virologic failure | 19.75 | 10.08 | 3 | 563617 | 4188 | 79176580 |
Respiratory disorder | 19.73 | 10.08 | 212 | 563408 | 44644 | 79136124 |
Potentiating drug interaction | 19.60 | 10.08 | 20 | 563600 | 8799 | 79171969 |
Haemorrhage | 19.57 | 10.08 | 492 | 563128 | 90626 | 79090142 |
Nasal polyps | 19.47 | 10.08 | 14 | 563606 | 7313 | 79173455 |
Jaundice cholestatic | 19.46 | 10.08 | 31 | 563589 | 11253 | 79169515 |
Flushing | 19.39 | 10.08 | 475 | 563145 | 87793 | 79092975 |
Lip swelling | 19.37 | 10.08 | 190 | 563430 | 40721 | 79140047 |
Ingrown hair | 19.32 | 10.08 | 25 | 563595 | 716 | 79180052 |
Sleep terror | 19.25 | 10.08 | 4 | 563616 | 4454 | 79176314 |
Product prescribing error | 19.23 | 10.08 | 213 | 563407 | 44600 | 79136168 |
Purpura | 19.17 | 10.08 | 72 | 563548 | 19455 | 79161313 |
Hepatitis fulminant | 19.14 | 10.08 | 14 | 563606 | 7248 | 79173520 |
Muscle twitching | 19.06 | 10.08 | 100 | 563520 | 24664 | 79156104 |
Multiple drug therapy | 19.04 | 10.08 | 3 | 563617 | 4075 | 79176693 |
Obstructive airways disorder | 19.01 | 10.08 | 137 | 563483 | 31322 | 79149446 |
Renal injury | 18.93 | 10.08 | 59 | 563561 | 16868 | 79163900 |
Progressive multifocal leukoencephalopathy | 18.92 | 10.08 | 78 | 563542 | 20522 | 79160246 |
Pulmonary congestion | 18.91 | 10.08 | 113 | 563507 | 26987 | 79153781 |
Eosinophil count increased | 18.86 | 10.08 | 60 | 563560 | 17045 | 79163723 |
Urinary retention | 18.82 | 10.08 | 284 | 563336 | 56346 | 79124422 |
Acute coronary syndrome | 18.80 | 10.08 | 81 | 563539 | 21052 | 79159716 |
Tubulointerstitial nephritis | 18.77 | 10.08 | 176 | 563444 | 38059 | 79142709 |
Oxygen saturation decreased | 18.75 | 10.08 | 1103 | 562517 | 127944 | 79052824 |
Pneumatosis intestinalis | 18.67 | 10.08 | 11 | 563609 | 6386 | 79174382 |
Post procedural infection | 18.56 | 10.08 | 141 | 563479 | 11243 | 79169525 |
Lower limb fracture | 18.53 | 10.08 | 248 | 563372 | 22967 | 79157801 |
Rash pruritic | 18.48 | 10.08 | 649 | 562971 | 70980 | 79109788 |
Metastases to lung | 18.47 | 10.08 | 66 | 563554 | 18097 | 79162671 |
Procedural pain | 18.45 | 10.08 | 92 | 563528 | 22992 | 79157776 |
Personality change | 18.44 | 10.08 | 27 | 563593 | 10143 | 79170625 |
Bone pain | 18.37 | 10.08 | 280 | 563340 | 55462 | 79125306 |
Body height below normal | 18.22 | 10.08 | 43 | 563577 | 2010 | 79178758 |
Maternal exposure during breast feeding | 18.20 | 10.08 | 52 | 563568 | 2733 | 79178035 |
Trisomy 18 | 18.20 | 10.08 | 22 | 563598 | 587 | 79180181 |
Ankle arthroplasty | 18.19 | 10.08 | 36 | 563584 | 1489 | 79179279 |
Respiratory acidosis | 18.18 | 10.08 | 32 | 563588 | 11168 | 79169600 |
Postoperative wound infection | 18.13 | 10.08 | 155 | 563465 | 12806 | 79167962 |
Pseudomonas infection | 18.06 | 10.08 | 81 | 563539 | 20822 | 79159946 |
Osteopenia | 18.04 | 10.08 | 204 | 563416 | 18160 | 79162608 |
Dysphagia | 18.04 | 10.08 | 693 | 562927 | 121443 | 79059325 |
Lymphopenia | 18.02 | 10.08 | 134 | 563486 | 30423 | 79150345 |
End stage renal disease | 18.01 | 10.08 | 37 | 563583 | 12183 | 79168585 |
Venoocclusive disease | 17.99 | 10.08 | 5 | 563615 | 4568 | 79176200 |
Hepatitis cholestatic | 17.93 | 10.08 | 45 | 563575 | 13807 | 79166961 |
Autoimmune disorder | 17.92 | 10.08 | 188 | 563432 | 16424 | 79164344 |
Rebound effect | 17.70 | 10.08 | 15 | 563605 | 7211 | 79173557 |
Oesophageal carcinoma | 17.69 | 10.08 | 32 | 563588 | 11052 | 79169716 |
General physical health deterioration | 17.69 | 10.08 | 2213 | 561407 | 273025 | 78907743 |
Aspartate aminotransferase increased | 17.66 | 10.08 | 800 | 562820 | 137841 | 79042927 |
Viral mutation identified | 17.65 | 10.08 | 3 | 563617 | 3855 | 79176913 |
Device related infection | 17.65 | 10.08 | 156 | 563464 | 34138 | 79146630 |
Subdural haematoma | 17.52 | 10.08 | 140 | 563480 | 31294 | 79149474 |
Hepatitis acute | 17.51 | 10.08 | 54 | 563566 | 15488 | 79165280 |
Bacteraemia | 17.48 | 10.08 | 148 | 563472 | 32676 | 79148092 |
Polyhydramnios | 17.47 | 10.08 | 38 | 563582 | 1682 | 79179086 |
Device expulsion | 17.44 | 10.08 | 109 | 563511 | 25752 | 79155016 |
Onychomycosis | 17.43 | 10.08 | 109 | 563511 | 8152 | 79172616 |
Drug tolerance | 17.40 | 10.08 | 113 | 563507 | 8562 | 79172206 |
Pulmonary haemorrhage | 17.39 | 10.08 | 50 | 563570 | 14667 | 79166101 |
Skin necrosis | 17.36 | 10.08 | 200 | 563420 | 17887 | 79162881 |
Injection site haemorrhage | 17.26 | 10.08 | 285 | 563335 | 27585 | 79153183 |
Gastric haemorrhage | 17.16 | 10.08 | 52 | 563568 | 14998 | 79165770 |
Parkinsonism | 17.04 | 10.08 | 60 | 563560 | 16524 | 79164244 |
Foot operation | 17.04 | 10.08 | 83 | 563537 | 5650 | 79175118 |
Breast feeding | 16.98 | 10.08 | 23 | 563597 | 689 | 79180079 |
Hypoalbuminaemia | 16.95 | 10.08 | 85 | 563535 | 21212 | 79159556 |
Blood lactate dehydrogenase increased | 16.88 | 10.08 | 186 | 563434 | 38984 | 79141784 |
Colitis ulcerative | 16.87 | 10.08 | 342 | 563278 | 34400 | 79146368 |
Short stature | 16.86 | 10.08 | 23 | 563597 | 694 | 79180074 |
Disturbance in social behaviour | 16.84 | 10.08 | 7 | 563613 | 4963 | 79175805 |
Acidosis | 16.82 | 10.08 | 77 | 563543 | 19685 | 79161083 |
Pulseless electrical activity | 16.81 | 10.08 | 48 | 563572 | 14112 | 79166656 |
Foetal distress syndrome | 16.74 | 10.08 | 19 | 563601 | 473 | 79180295 |
Glomerular filtration rate decreased | 16.74 | 10.08 | 93 | 563527 | 22609 | 79158159 |
Surgery | 16.73 | 10.08 | 325 | 563295 | 32441 | 79148327 |
Vascular stent thrombosis | 16.72 | 10.08 | 3 | 563617 | 3707 | 79177061 |
Musculoskeletal disorder | 16.66 | 10.08 | 228 | 563392 | 21220 | 79159548 |
Heart rate irregular | 16.64 | 10.08 | 324 | 563296 | 32355 | 79148413 |
Injury | 16.62 | 10.08 | 688 | 562932 | 76808 | 79103960 |
COVID-19 | 16.57 | 10.08 | 928 | 562692 | 156746 | 79024022 |
Rhinitis allergic | 16.55 | 10.08 | 39 | 563581 | 12230 | 79168538 |
Accidental death | 16.32 | 10.08 | 5 | 563615 | 4286 | 79176482 |
Mental disorder | 16.28 | 10.08 | 142 | 563478 | 31160 | 79149608 |
Hepatic cancer | 16.27 | 10.08 | 31 | 563589 | 10498 | 79170270 |
Placental disorder | 16.26 | 10.08 | 26 | 563594 | 907 | 79179861 |
Coordination abnormal | 16.24 | 10.08 | 65 | 563555 | 17247 | 79163521 |
Prescribed overdose | 16.16 | 10.08 | 366 | 563254 | 37517 | 79143251 |
Paralysis | 16.14 | 10.08 | 44 | 563576 | 13133 | 79167635 |
Blood urea increased | 16.10 | 10.08 | 245 | 563375 | 48545 | 79132223 |
Acute respiratory failure | 16.09 | 10.08 | 310 | 563310 | 59231 | 79121537 |
Haematuria | 16.07 | 10.08 | 367 | 563253 | 68469 | 79112299 |
Personality disorder | 16.00 | 10.08 | 12 | 563608 | 6134 | 79174634 |
Normal newborn | 15.99 | 10.08 | 95 | 563525 | 6977 | 79173791 |
Pharyngitis streptococcal | 15.98 | 10.08 | 130 | 563490 | 10584 | 79170184 |
Lipase increased | 15.98 | 10.08 | 61 | 563559 | 16405 | 79164363 |
Dysgeusia | 15.97 | 10.08 | 296 | 563324 | 56881 | 79123887 |
Device leakage | 15.89 | 10.08 | 33 | 563587 | 10823 | 79169945 |
Respiration abnormal | 15.84 | 10.08 | 19 | 563601 | 7769 | 79172999 |
Strongyloidiasis | 15.83 | 10.08 | 4 | 563616 | 3894 | 79176874 |
Endodontic procedure | 15.82 | 10.08 | 49 | 563571 | 2694 | 79178074 |
Intervertebral disc degeneration | 15.80 | 10.08 | 176 | 563444 | 15609 | 79165159 |
Fluid retention | 15.79 | 10.08 | 374 | 563246 | 69435 | 79111333 |
Dizziness | 15.73 | 10.08 | 3385 | 560235 | 523056 | 78657712 |
Injection site urticaria | 15.70 | 10.08 | 149 | 563471 | 12677 | 79168091 |
Alcoholic liver disease | 15.69 | 10.08 | 20 | 563600 | 564 | 79180204 |
Decreased gait velocity | 15.68 | 10.08 | 12 | 563608 | 177 | 79180591 |
Atrioventricular block | 15.66 | 10.08 | 49 | 563571 | 13992 | 79166776 |
Polyuria | 15.64 | 10.08 | 54 | 563566 | 14960 | 79165808 |
Amylase increased | 15.63 | 10.08 | 35 | 563585 | 11174 | 79169594 |
Neck pain | 15.59 | 10.08 | 667 | 562953 | 74750 | 79106018 |
Jaundice | 15.59 | 10.08 | 274 | 563346 | 53075 | 79127693 |
Coronary artery bypass | 15.57 | 10.08 | 12 | 563608 | 6050 | 79174718 |
Bradypnoea | 15.52 | 10.08 | 12 | 563608 | 6040 | 79174728 |
Ventricular arrhythmia | 15.52 | 10.08 | 24 | 563596 | 8816 | 79171952 |
Pain in jaw | 15.49 | 10.08 | 231 | 563389 | 45920 | 79134848 |
Radiation inflammation | 15.48 | 10.08 | 25 | 563595 | 880 | 79179888 |
Acute lymphocytic leukaemia recurrent | 15.45 | 10.08 | 7 | 563613 | 4717 | 79176051 |
Bone marrow failure | 15.41 | 10.08 | 261 | 563359 | 50846 | 79129922 |
Cushingoid | 15.40 | 10.08 | 118 | 563502 | 9434 | 79171334 |
Cholangitis | 15.40 | 10.08 | 43 | 563577 | 12733 | 79168035 |
Knee operation | 15.39 | 10.08 | 82 | 563538 | 5784 | 79174984 |
Right ventricular failure | 15.35 | 10.08 | 100 | 563520 | 23397 | 79157371 |
Pulmonary hypertension | 15.34 | 10.08 | 243 | 563377 | 47837 | 79132931 |
Antibody test positive | 15.30 | 10.08 | 49 | 563571 | 2743 | 79178025 |
Hypertriglyceridaemia | 15.27 | 10.08 | 43 | 563577 | 12697 | 79168071 |
Depression | 15.17 | 10.08 | 1322 | 562298 | 215468 | 78965300 |
Sickle cell anaemia | 15.16 | 10.08 | 21 | 563599 | 643 | 79180125 |
Skin toxicity | 15.15 | 10.08 | 22 | 563598 | 8292 | 79172476 |
Deformity | 15.13 | 10.08 | 118 | 563502 | 9487 | 79171281 |
Kidney transplant rejection | 15.12 | 10.08 | 31 | 563589 | 10215 | 79170553 |
Sleep disorder due to a general medical condition | 15.11 | 10.08 | 51 | 563569 | 14226 | 79166542 |
Bone cyst | 15.10 | 10.08 | 56 | 563564 | 3377 | 79177391 |
Type 1 diabetes mellitus | 15.03 | 10.08 | 16 | 563604 | 6903 | 79173865 |
Hypercapnia | 14.99 | 10.08 | 25 | 563595 | 8910 | 79171858 |
COVID-19 pneumonia | 14.95 | 10.08 | 131 | 563489 | 28718 | 79152050 |
Hypoxic-ischaemic encephalopathy | 14.94 | 10.08 | 20 | 563600 | 7800 | 79172968 |
Appendicitis | 14.89 | 10.08 | 86 | 563534 | 20708 | 79160060 |
Chronic sinusitis | 14.86 | 10.08 | 45 | 563575 | 12981 | 79167787 |
Acute graft versus host disease in intestine | 14.85 | 10.08 | 5 | 563615 | 4036 | 79176732 |
Prostatic specific antigen increased | 14.84 | 10.08 | 32 | 563588 | 10354 | 79170414 |
Diaphragmatic disorder | 14.83 | 10.08 | 36 | 563584 | 1714 | 79179054 |
Encephalitis toxic | 14.83 | 10.08 | 14 | 563606 | 279 | 79180489 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 14.82 | 10.08 | 4 | 563616 | 3725 | 79177043 |
Induced labour | 14.79 | 10.08 | 24 | 563596 | 848 | 79179920 |
Hypomania | 14.72 | 10.08 | 19 | 563601 | 7525 | 79173243 |
Blood phosphorus increased | 14.68 | 10.08 | 32 | 563588 | 10315 | 79170453 |
Haematoma | 14.64 | 10.08 | 270 | 563350 | 51925 | 79128843 |
Lacrimal disorder | 14.58 | 10.08 | 18 | 563602 | 491 | 79180277 |
Diabetes mellitus | 14.57 | 10.08 | 432 | 563188 | 77958 | 79102810 |
Stillbirth | 14.56 | 10.08 | 61 | 563559 | 3894 | 79176874 |
Heparin-induced thrombocytopenia | 14.54 | 10.08 | 29 | 563591 | 9653 | 79171115 |
International normalised ratio increased | 14.50 | 10.08 | 472 | 563148 | 84249 | 79096519 |
Diabetes mellitus inadequate control | 14.50 | 10.08 | 106 | 563514 | 24158 | 79156610 |
Kidney infection | 14.49 | 10.08 | 226 | 563394 | 21625 | 79159143 |
Hyperlactacidaemia | 14.47 | 10.08 | 11 | 563609 | 5584 | 79175184 |
Immunosuppressant drug level increased | 14.46 | 10.08 | 26 | 563594 | 9001 | 79171767 |
Erectile dysfunction | 14.44 | 10.08 | 54 | 563566 | 14610 | 79166158 |
Lymph gland infection | 14.42 | 10.08 | 19 | 563601 | 554 | 79180214 |
Chest pain | 14.38 | 10.08 | 1761 | 561859 | 280543 | 78900225 |
Hypernatraemia | 14.37 | 10.08 | 53 | 563567 | 14398 | 79166370 |
Pneumonia bacterial | 14.35 | 10.08 | 79 | 563541 | 19252 | 79161516 |
Drug screen positive | 14.35 | 10.08 | 13 | 563607 | 6050 | 79174718 |
Dry eye | 14.29 | 10.08 | 352 | 563268 | 36579 | 79144189 |
Product administered to patient of inappropriate age | 14.26 | 10.08 | 11 | 563609 | 5542 | 79175226 |
Lower respiratory tract congestion | 14.21 | 10.08 | 61 | 563559 | 3936 | 79176832 |
Paranoia | 14.11 | 10.08 | 80 | 563540 | 19352 | 79161416 |
Anticholinergic syndrome | 14.11 | 10.08 | 4 | 563616 | 3607 | 79177161 |
Red blood cell count decreased | 14.07 | 10.08 | 518 | 563102 | 56995 | 79123773 |
Anal fissure | 14.05 | 10.08 | 98 | 563522 | 7605 | 79173163 |
Renal disorder | 14.04 | 10.08 | 211 | 563409 | 41894 | 79138874 |
Tooth disorder | 14.01 | 10.08 | 262 | 563358 | 25971 | 79154797 |
Upper respiratory tract infection | 13.96 | 10.08 | 783 | 562837 | 90385 | 79090383 |
Hydrocephalus | 13.93 | 10.08 | 26 | 563594 | 8874 | 79171894 |
Diabetes insipidus | 13.93 | 10.08 | 10 | 563610 | 5227 | 79175541 |
Psychomotor skills impaired | 13.93 | 10.08 | 10 | 563610 | 5227 | 79175541 |
Foetal exposure during pregnancy | 13.89 | 10.08 | 79 | 563541 | 5711 | 79175057 |
Dactylitis | 13.87 | 10.08 | 47 | 563573 | 2710 | 79178058 |
Incorrect route of product administration | 13.83 | 10.08 | 169 | 563451 | 34760 | 79146008 |
Transaminases increased | 13.80 | 10.08 | 270 | 563350 | 51473 | 79129295 |
Osteoporotic fracture | 13.78 | 10.08 | 63 | 563557 | 4177 | 79176591 |
Joint lock | 13.68 | 10.08 | 52 | 563568 | 3173 | 79177595 |
Tuberculin test positive | 13.68 | 10.08 | 54 | 563566 | 3354 | 79177414 |
Type I hypersensitivity | 13.65 | 10.08 | 7 | 563613 | 4391 | 79176377 |
Salivary hypersecretion | 13.61 | 10.08 | 53 | 563567 | 14171 | 79166597 |
Spinal osteoarthritis | 13.58 | 10.08 | 181 | 563439 | 16746 | 79164022 |
Dry skin | 13.58 | 10.08 | 371 | 563249 | 67624 | 79113144 |
Persecutory delusion | 13.55 | 10.08 | 9 | 563611 | 4900 | 79175868 |
Bone density abnormal | 13.53 | 10.08 | 50 | 563570 | 3010 | 79177758 |
Hypoaesthesia | 13.52 | 10.08 | 1457 | 562163 | 177895 | 79002873 |
Complications of transplanted kidney | 13.52 | 10.08 | 15 | 563605 | 6351 | 79174417 |
Systemic inflammatory response syndrome | 13.51 | 10.08 | 39 | 563581 | 11426 | 79169342 |
Lymphatic fistula | 13.48 | 10.08 | 22 | 563598 | 781 | 79179987 |
Ileus paralytic | 13.45 | 10.08 | 30 | 563590 | 9590 | 79171178 |
Feeling abnormal | 13.44 | 10.08 | 956 | 562664 | 158243 | 79022525 |
Toxic encephalopathy | 13.42 | 10.08 | 39 | 563581 | 11401 | 79169367 |
Immunosuppression | 13.39 | 10.08 | 144 | 563476 | 12659 | 79168109 |
Atrioventricular block complete | 13.39 | 10.08 | 66 | 563554 | 16544 | 79164224 |
Wound infection pseudomonas | 13.37 | 10.08 | 33 | 563587 | 1588 | 79179180 |
Human herpesvirus 6 infection | 13.33 | 10.08 | 11 | 563609 | 5359 | 79175409 |
Hyperpyrexia | 13.33 | 10.08 | 14 | 563606 | 6078 | 79174690 |
Hypertonia | 13.31 | 10.08 | 19 | 563601 | 7213 | 79173555 |
Intracranial pressure increased | 13.31 | 10.08 | 24 | 563596 | 8298 | 79172470 |
Hypoventilation | 13.28 | 10.08 | 19 | 563601 | 7205 | 79173563 |
Gastric cancer | 13.23 | 10.08 | 33 | 563587 | 10146 | 79170622 |
Subarachnoid haemorrhage | 13.16 | 10.08 | 110 | 563510 | 24355 | 79156413 |
Pulmonary tuberculosis | 13.16 | 10.08 | 98 | 563522 | 7767 | 79173001 |
Coronary arterial stent insertion | 13.10 | 10.08 | 14 | 563606 | 6030 | 79174738 |
Toothache | 13.04 | 10.08 | 206 | 563414 | 19764 | 79161004 |
Clear cell renal cell carcinoma | 13.03 | 10.08 | 44 | 563576 | 2532 | 79178236 |
Ligament rupture | 13.00 | 10.08 | 53 | 563567 | 3341 | 79177427 |
Renal tubular disorder | 13.00 | 10.08 | 16 | 563604 | 6470 | 79174298 |
C-reactive protein decreased | 13.00 | 10.08 | 45 | 563575 | 2623 | 79178145 |
Walking aid user | 12.98 | 10.08 | 119 | 563501 | 10029 | 79170739 |
Drug dose omission by device | 12.97 | 10.08 | 15 | 563605 | 6235 | 79174533 |
Palmoplantar keratoderma | 12.97 | 10.08 | 5 | 563615 | 3711 | 79177057 |
Haemorrhage in pregnancy | 12.97 | 10.08 | 30 | 563590 | 1384 | 79179384 |
Laryngospasm | 12.96 | 10.08 | 6 | 563614 | 3991 | 79176777 |
Vascular purpura | 12.93 | 10.08 | 3 | 563617 | 3095 | 79177673 |
Cellulitis | 12.91 | 10.08 | 916 | 562704 | 108144 | 79072624 |
Hypothyroidism | 12.90 | 10.08 | 277 | 563343 | 52115 | 79128653 |
Hypophosphataemia | 12.88 | 10.08 | 85 | 563535 | 19828 | 79160940 |
Tooth abscess | 12.87 | 10.08 | 173 | 563447 | 16037 | 79164731 |
Skin neoplasm excision | 12.79 | 10.08 | 25 | 563595 | 1025 | 79179743 |
Acute myeloid leukaemia recurrent | 12.76 | 10.08 | 4 | 563616 | 3379 | 79177389 |
Metastasis | 12.74 | 10.08 | 18 | 563602 | 6862 | 79173906 |
Abortion incomplete | 12.73 | 10.08 | 3 | 563617 | 3061 | 79177707 |
Femoral hernia incarcerated | 12.72 | 10.08 | 22 | 563598 | 820 | 79179948 |
Myopathy | 12.69 | 10.08 | 89 | 563531 | 20474 | 79160294 |
Reversible cerebral vasoconstriction syndrome | 12.68 | 10.08 | 3 | 563617 | 3054 | 79177714 |
Injection site extravasation | 12.68 | 10.08 | 114 | 563506 | 9555 | 79171213 |
Carotid artery thrombosis | 12.66 | 10.08 | 3 | 563617 | 3050 | 79177718 |
C-reactive protein | 12.65 | 10.08 | 69 | 563551 | 4910 | 79175858 |
Tooth infection | 12.57 | 10.08 | 195 | 563425 | 18637 | 79162131 |
Angina unstable | 12.57 | 10.08 | 67 | 563553 | 16460 | 79164308 |
Cervical incompetence | 12.54 | 10.08 | 17 | 563603 | 510 | 79180258 |
Cell death | 12.46 | 10.08 | 9 | 563611 | 4690 | 79176078 |
Hyperlipidaemia | 12.43 | 10.08 | 121 | 563499 | 25972 | 79154796 |
Oligoarthritis | 12.38 | 10.08 | 20 | 563600 | 704 | 79180064 |
Sensitisation | 12.34 | 10.08 | 4 | 563616 | 3307 | 79177461 |
Myofascial pain syndrome | 12.32 | 10.08 | 37 | 563583 | 2000 | 79178768 |
Metastases to meninges | 12.32 | 10.08 | 5 | 563615 | 3596 | 79177172 |
Small for dates baby | 12.31 | 10.08 | 16 | 563604 | 460 | 79180308 |
Blood folate increased | 12.31 | 10.08 | 17 | 563603 | 519 | 79180249 |
Nightmare | 12.29 | 10.08 | 120 | 563500 | 25741 | 79155027 |
Joint warmth | 12.29 | 10.08 | 32 | 563588 | 1592 | 79179176 |
Visual acuity reduced | 12.28 | 10.08 | 141 | 563479 | 29328 | 79151440 |
Muscle spasticity | 12.27 | 10.08 | 95 | 563525 | 21380 | 79159388 |
Pulmonary function test abnormal | 12.27 | 10.08 | 7 | 563613 | 4137 | 79176631 |
Breast abscess | 12.26 | 10.08 | 30 | 563590 | 1436 | 79179332 |
Human anti-human antibody test | 12.18 | 10.08 | 15 | 563605 | 408 | 79180360 |
Immune effector cell-associated neurotoxicity syndrome | 12.18 | 10.08 | 14 | 563606 | 5834 | 79174934 |
Generalised oedema | 12.13 | 10.08 | 108 | 563512 | 23601 | 79157167 |
Abortion threatened | 12.13 | 10.08 | 15 | 563605 | 410 | 79180358 |
Osteonecrosis | 12.11 | 10.08 | 151 | 563469 | 30944 | 79149824 |
Drug hypersensitivity | 12.10 | 10.08 | 1891 | 561729 | 297025 | 78883743 |
Alcohol interaction | 12.08 | 10.08 | 10 | 563610 | 4864 | 79175904 |
Lip blister | 12.06 | 10.08 | 45 | 563575 | 2722 | 79178046 |
Generalised tonic-clonic seizure | 12.05 | 10.08 | 228 | 563392 | 43682 | 79137086 |
Cyst rupture | 12.05 | 10.08 | 19 | 563601 | 655 | 79180113 |
Hepatitis E antibody positive | 12.05 | 10.08 | 12 | 563608 | 256 | 79180512 |
Therapy non-responder | 11.93 | 10.08 | 781 | 562839 | 91524 | 79089244 |
Bacterial sepsis | 11.93 | 10.08 | 25 | 563595 | 8173 | 79172595 |
Epstein-Barr virus associated lymphoproliferative disorder | 11.92 | 10.08 | 5 | 563615 | 3527 | 79177241 |
Accidental exposure to product by child | 11.89 | 10.08 | 3 | 563617 | 2923 | 79177845 |
Anal fistula | 11.89 | 10.08 | 87 | 563533 | 6857 | 79173911 |
Drug abuser | 11.88 | 10.08 | 15 | 563605 | 5998 | 79174770 |
Hyperthermia malignant | 11.84 | 10.08 | 3 | 563617 | 2914 | 79177854 |
Steroid diabetes | 11.78 | 10.08 | 5 | 563615 | 3501 | 79177267 |
Neurologic neglect syndrome | 11.77 | 10.08 | 3 | 563617 | 2904 | 79177864 |
Nephrotic syndrome | 11.77 | 10.08 | 40 | 563580 | 11134 | 79169634 |
Peritoneal dialysis complication | 11.73 | 10.08 | 40 | 563580 | 2314 | 79178454 |
Threatened labour | 11.73 | 10.08 | 18 | 563602 | 606 | 79180162 |
Joint ankylosis | 11.71 | 10.08 | 38 | 563582 | 2142 | 79178626 |
Hypocalcaemia | 11.70 | 10.08 | 266 | 563354 | 49658 | 79131110 |
Drug specific antibody | 11.67 | 10.08 | 43 | 563577 | 2585 | 79178183 |
Spondylitis | 11.64 | 10.08 | 65 | 563555 | 4666 | 79176102 |
Nail injury | 11.64 | 10.08 | 18 | 563602 | 610 | 79180158 |
Placental insufficiency | 11.62 | 10.08 | 25 | 563595 | 1098 | 79179670 |
Oesophageal fibrosis | 11.61 | 10.08 | 10 | 563610 | 176 | 79180592 |
Incoherent | 11.58 | 10.08 | 23 | 563597 | 7669 | 79173099 |
Defaecation disorder | 11.49 | 10.08 | 19 | 563601 | 682 | 79180086 |
Respiratory tract infection viral | 11.49 | 10.08 | 60 | 563560 | 4199 | 79176569 |
Pneumonia aspiration | 11.48 | 10.08 | 373 | 563247 | 66594 | 79114174 |
Depressed mood | 11.45 | 10.08 | 258 | 563362 | 48222 | 79132546 |
Starvation ketoacidosis | 11.42 | 10.08 | 9 | 563611 | 139 | 79180629 |
Renal cancer | 11.41 | 10.08 | 46 | 563574 | 12180 | 79168588 |
Diplopia | 11.41 | 10.08 | 167 | 563453 | 33299 | 79147469 |
Left ventricular dysfunction | 11.37 | 10.08 | 85 | 563535 | 19276 | 79161492 |
Vascular device infection | 11.36 | 10.08 | 36 | 563584 | 10240 | 79170528 |
Skin injury | 11.36 | 10.08 | 51 | 563569 | 3355 | 79177413 |
Ventricular hypokinesia | 11.36 | 10.08 | 31 | 563589 | 9248 | 79171520 |
Road traffic accident | 11.35 | 10.08 | 396 | 563224 | 43268 | 79137500 |
Aphthous ulcer | 11.32 | 10.08 | 175 | 563445 | 16714 | 79164054 |
Psychiatric decompensation | 11.30 | 10.08 | 7 | 563613 | 3956 | 79176812 |
Tooth fracture | 11.29 | 10.08 | 128 | 563492 | 11402 | 79169366 |
Aplasia | 11.25 | 10.08 | 24 | 563596 | 7796 | 79172972 |
Gestational hypertension | 11.24 | 10.08 | 34 | 563586 | 1845 | 79178923 |
Panic attack | 11.24 | 10.08 | 113 | 563507 | 24103 | 79156665 |
Anger | 11.23 | 10.08 | 73 | 563547 | 17089 | 79163679 |
Chills | 11.22 | 10.08 | 977 | 562643 | 159257 | 79021511 |
Acute pulmonary oedema | 11.21 | 10.08 | 57 | 563563 | 14173 | 79166595 |
Lung opacity | 11.20 | 10.08 | 12 | 563608 | 5162 | 79175606 |
Mitochondrial toxicity | 11.19 | 10.08 | 4 | 563616 | 3110 | 79177658 |
Arthropod bite | 11.17 | 10.08 | 100 | 563520 | 8371 | 79172397 |
Renal tubular necrosis | 11.15 | 10.08 | 118 | 563502 | 24921 | 79155847 |
Acute lung injury | 11.11 | 10.08 | 4 | 563616 | 3096 | 79177672 |
Rash erythematous | 11.08 | 10.08 | 317 | 563303 | 57452 | 79123316 |
Pseudomembranous colitis | 11.05 | 10.08 | 13 | 563607 | 5361 | 79175407 |
Iodine allergy | 11.04 | 10.08 | 17 | 563603 | 574 | 79180194 |
Spinal disorder | 11.01 | 10.08 | 116 | 563504 | 10144 | 79170624 |
Genital haemorrhage | 10.96 | 10.08 | 17 | 563603 | 6238 | 79174530 |
Candida infection | 10.93 | 10.08 | 197 | 563423 | 38017 | 79142751 |
Adverse drug reaction | 10.92 | 10.08 | 574 | 563046 | 65818 | 79114950 |
Complication of device removal | 10.91 | 10.08 | 7 | 563613 | 3882 | 79176886 |
Sarcopenia | 10.91 | 10.08 | 15 | 563605 | 456 | 79180312 |
Delusion | 10.91 | 10.08 | 92 | 563528 | 20331 | 79160437 |
Benign ovarian tumour | 10.90 | 10.08 | 13 | 563607 | 342 | 79180426 |
Inadequate analgesia | 10.86 | 10.08 | 10 | 563610 | 4619 | 79176149 |
Hepatitis B | 10.84 | 10.08 | 27 | 563593 | 8305 | 79172463 |
Proctitis | 10.79 | 10.08 | 18 | 563602 | 6414 | 79174354 |
Hypercholesterolaemia | 10.77 | 10.08 | 226 | 563394 | 22869 | 79157899 |
Pleural fibrosis | 10.76 | 10.08 | 58 | 563562 | 4109 | 79176659 |
Cardiomyopathy | 10.73 | 10.08 | 141 | 563479 | 28633 | 79152135 |
Product monitoring error | 10.72 | 10.08 | 30 | 563590 | 8876 | 79171892 |
Hernia pain | 10.71 | 10.08 | 15 | 563605 | 464 | 79180304 |
Pulmonary pain | 10.71 | 10.08 | 61 | 563559 | 4412 | 79176356 |
Bronchial secretion retention | 10.70 | 10.08 | 8 | 563612 | 4096 | 79176672 |
Eyelid oedema | 10.68 | 10.08 | 55 | 563565 | 13632 | 79167136 |
Skin exfoliation | 10.65 | 10.08 | 302 | 563318 | 54798 | 79125970 |
Eye infection | 10.64 | 10.08 | 130 | 563490 | 11790 | 79168978 |
Foetal death | 10.63 | 10.08 | 95 | 563525 | 7949 | 79172819 |
Mass | 10.57 | 10.08 | 178 | 563442 | 17294 | 79163474 |
Lung transplant | 10.53 | 10.08 | 10 | 563610 | 4551 | 79176217 |
Neutropenic colitis | 10.50 | 10.08 | 15 | 563605 | 5692 | 79175076 |
Arthritis bacterial | 10.49 | 10.08 | 105 | 563515 | 9061 | 79171707 |
Complication of device insertion | 10.44 | 10.08 | 18 | 563602 | 6332 | 79174436 |
Serum ferritin increased | 10.41 | 10.08 | 111 | 563509 | 9736 | 79171032 |
Bone density increased | 10.41 | 10.08 | 20 | 563600 | 809 | 79179959 |
Presyncope | 10.41 | 10.08 | 216 | 563404 | 40838 | 79139930 |
Colitis microscopic | 10.38 | 10.08 | 40 | 563580 | 10728 | 79170040 |
Dermatitis allergic | 10.36 | 10.08 | 183 | 563437 | 17947 | 79162821 |
Upper respiratory tract inflammation | 10.35 | 10.08 | 8 | 563612 | 4027 | 79176741 |
Skin ulcer haemorrhage | 10.31 | 10.08 | 16 | 563604 | 544 | 79180224 |
Cirrhosis alcoholic | 10.31 | 10.08 | 23 | 563597 | 1036 | 79179732 |
Cartilage injury | 10.27 | 10.08 | 29 | 563591 | 1514 | 79179254 |
Paresis | 10.25 | 10.08 | 9 | 563611 | 4252 | 79176516 |
Device occlusion | 10.24 | 10.08 | 46 | 563574 | 11820 | 79168948 |
Intestinal stenosis | 10.21 | 10.08 | 53 | 563567 | 3701 | 79177067 |
Cryptococcosis | 10.20 | 10.08 | 6 | 563614 | 3487 | 79177281 |
Pancreatic steatosis | 10.18 | 10.08 | 24 | 563596 | 1121 | 79179647 |
Vacuum extractor delivery | 10.18 | 10.08 | 8 | 563612 | 123 | 79180645 |
Cholestasis of pregnancy | 10.15 | 10.08 | 22 | 563598 | 971 | 79179797 |
Paraesthesia oral | 10.15 | 10.08 | 94 | 563526 | 20377 | 79160391 |
CD4 lymphocytes decreased | 10.14 | 10.08 | 3 | 563617 | 2631 | 79178137 |
Hypogammaglobulinaemia | 10.13 | 10.08 | 52 | 563568 | 12899 | 79167869 |
Stress at work | 10.10 | 10.08 | 24 | 563596 | 1127 | 79179641 |
Hand fracture | 10.09 | 10.08 | 77 | 563543 | 6148 | 79174620 |
None
Source | Code | Description |
---|---|---|
ATC | A11DA01 | ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12 Vitamin B1, plain |
MeSH PA | D018977 | Micronutrients |
MeSH PA | D014803 | Vitamin B Complex |
MeSH PA | D014815 | Vitamins |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
CHEBI has role | CHEBI:76971 | Escherichia coli metabolites |
CHEBI has role | CHEBI:77746 | Homo sapiens metabolite |
CHEBI has role | CHEBI:71692 | insect repellents |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Korsakoff's psychosis | indication | 69482004 | DOID:10915 |
Pernicious anemia | indication | 84027009 | DOID:13381 |
Vitamin deficiency | indication | 85670002 | |
Mineral deficiency | indication | 111379007 | |
Cobalamin deficiency | indication | 190634004 | |
Thiamin deficiency | indication | 399357009 | DOID:0070313 |
Vitamin Deficiency Prevention | indication | ||
Mineral Deficiency Prevention | indication | ||
Prevention of Vitamin B12 Deficiency | indication | ||
Methylmalonic acidemia | off-label use | 42393006 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Alcoholism | contraindication | 7200002 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Chronic heart failure | contraindication | 48447003 | |
Gastrointestinal perforation | contraindication | 51875005 | |
Gastrectomy | contraindication | 53442002 | |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Hepatic failure | contraindication | 59927004 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Hemophilia | contraindication | 90935002 | |
Seizure disorder | contraindication | 128613002 | |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Impaired renal function disorder | contraindication | 197663003 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Pregnancy, function | contraindication | 289908002 | |
Panic disorder | contraindication | 371631005 | DOID:594 |
Cardiovascular event risk | contraindication | 395112001 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Smokes tobacco daily | contraindication | 449868002 | |
Acute Thromboembolic Stroke | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 4.94 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Thiamine transporter 1 | Transporter | WOMBAT-PK | |||||||
Transketolase | Enzyme | WOMBAT-PK | |||||||
Thiamin pyrophosphokinase 1 | Kinase | WOMBAT-PK | |||||||
Thiamine-triphosphatase | Enzyme | WOMBAT-PK | |||||||
Transketolase-like protein 1 | Enzyme | WOMBAT-PK | |||||||
Heat shock protein HSP 90-alpha | Cytosolic other | IC50 | 4.90 | CHEMBL | |||||
Thiamine transporter ThiT | Transporter | Kd | 9.91 | CHEMBL |
ID | Source |
---|---|
4017777 | VUID |
N0000146138 | NUI |
D08580 | KEGG_DRUG |
67-03-8 | SECONDARY_CAS_RN |
532-43-4 | SECONDARY_CAS_RN |
4017446 | VANDF |
4017474 | VANDF |
4017634 | VANDF |
4017777 | VANDF |
4021900 | VANDF |
C0039840 | UMLSCUI |
CHEBI:26948 | CHEBI |
VIB | PDB_CHEM_ID |
CHEMBL1547 | ChEMBL_ID |
CHEMBL1588 | ChEMBL_ID |
CHEMBL1200941 | ChEMBL_ID |
DB00152 | DRUGBANK_ID |
CHEMBL2104496 | ChEMBL_ID |
D013831 | MESH_DESCRIPTOR_UI |
C000712172 | MESH_SUPPLEMENTAL_RECORD_UI |
1130 | PUBCHEM_CID |
4629 | IUPHAR_LIGAND_ID |
432 | INN_ID |
X66NSO3N35 | UNII |
10454 | RXNORM |
1096 | MMSL |
15466 | MMSL |
41397 | MMSL |
5566 | MMSL |
5681 | MMSL |
7276 | MMSL |
d03130 | MMSL |
001061 | NDDF |
001062 | NDDF |
003860 | NDDF |
126228004 | SNOMEDCT_US |
126229007 | SNOMEDCT_US |
259659006 | SNOMEDCT_US |
30306003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
NataFort | HUMAN PRESCRIPTION DRUG LABEL | 10 | 0178-0716 | TABLET | 2 mg | ORAL | Unapproved drug other | 12 sections |
CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 3 mg | ORAL | unapproved drug other | 11 sections |
CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 4.54 mg | ORAL | unapproved drug other | 11 sections |
CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 3 mg | ORAL | unapproved drug other | 11 sections |
CitraNatal 90 DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0178-0821 | TABLET | 4.54 mg | ORAL | unapproved drug other | 11 sections |
CitraNatal 90 DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0829 | TABLET | 3 mg | ORAL | Unapproved drug other | 11 sections |
CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0178-0858 | TABLET | 3 mg | ORAL | Unapproved drug other | 12 sections |
CitraNatal Rx | HUMAN PRESCRIPTION DRUG LABEL | 14 | 0178-0859 | TABLET | 3 mg | ORAL | Unapproved drug other | 9 sections |
CitraNatal DHA | HUMAN OTC DRUG LABEL | 14 | 0178-0898 | TABLET | 3 mg | ORAL | Unapproved drug other | 11 sections |
THIAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9963 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 11 sections |
THIAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9963 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 11 sections |
THIAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9963 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 11 sections |
THIAMINE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0404-9963 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 11 sections |
Thiamine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6228 | INJECTION, SOLUTION | 100 mg | INTRAMUSCULAR | ANDA | 15 sections |
VitafolOne | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-0070 | CAPSULE, GELATIN COATED | 1.60 mg | ORAL | unapproved drug other | 14 sections |
Vitafol Caplet | HUMAN PRESCRIPTION DRUG LABEL | 12 | 0642-0072 | CAPSULE | 1.10 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0077 | TABLET, CHEWABLE | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Vitafol OB Caplet | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0079 | TABLET | 1.60 mg | ORAL | Unapproved drug other | 14 sections |
Vitafol OB Caplet | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0079 | TABLET | 1.60 mg | ORAL | Unapproved drug other | 14 sections |
Vitafol Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0092 | CAPSULE, LIQUID FILLED | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
Vitafol Ultra | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0093 | CAPSULE, LIQUID FILLED | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
Vitafol Ultra | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-0093 | CAPSULE, LIQUID FILLED | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
Select OB | HUMAN PRESCRIPTION DRUG LABEL | 15 | 0642-0120 | TABLET, CHEWABLE | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 13 sections |
Strovite Forte Caplet | HUMAN PRESCRIPTION DRUG LABEL | 19 | 0642-0204 | TABLET, COATED | 20 mg | ORAL | UNAPPROVED DRUG OTHER | 15 sections |
Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 20 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Strovite One Caplets | HUMAN PRESCRIPTION DRUG LABEL | 20 | 0642-0207 | TABLET | 20 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Reaphirm Plant Source DHA | HUMAN PRESCRIPTION DRUG LABEL | 16 | 0642-3010 | CAPSULE, GELATIN COATED | 1.60 mg | ORAL | unapproved drug other | 7 sections |
Vitafol Fe Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-7473 | CAPSULE, LIQUID FILLED | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Vitafol Fe Plus | HUMAN PRESCRIPTION DRUG LABEL | 17 | 0642-7473 | CAPSULE, LIQUID FILLED | 1.60 mg | ORAL | UNAPPROVED DRUG OTHER | 14 sections |
Marnatal F | HUMAN PRESCRIPTION DRUG LABEL | 13 | 0682-1570 | CAPSULE | 3 mg | ORAL | UNAPPROVED DRUG OTHER | 4 sections |