valganciclovir ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 2801 175865-59-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valganciclovir
  • valganciclovir hydrochloride
  • valganciclovir HCl
Valganciclovir is an L-valyl ester (prodrug) of ganciclovir that exists as a mixture of two diastereomers. After oral administration, both diastereomers are rapidly converted to ganciclovir by intestinal and hepatic esterases. Ganciclovir is a synthetic analogue of 2'-deoxyguanosine, which inhibits replication of human CMV in cell culture and in vivo.
  • Molecular weight: 354.37
  • Formula: C14H22N6O5
  • CLOGP: -1.60
  • LIPINSKI: 1
  • HAC: 11
  • HDO: 4
  • TPSA: 167.08
  • ALOGS: -1.89
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.90 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 70 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 84.66 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 61 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 29, 2001 FDA HOFFMANN LA ROCHE
Nov. 5, 2004 PMDA Tanabe Seiyaku Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1007.15 19.35 324 16241 20628 63451829
Leukopenia 486.80 19.35 283 16282 77007 63395450
Cytomegalovirus viraemia 485.92 19.35 137 16428 5512 63466945
Transplant rejection 469.96 19.35 155 16410 10625 63461832
Pathogen resistance 378.04 19.35 116 16449 6282 63466175
Drug resistance 362.63 19.35 157 16408 22776 63449681
Neutropenia 302.94 19.35 295 16270 174710 63297747
Off label use 231.93 19.35 528 16037 673934 62798523
BK virus infection 221.80 19.35 66 16499 3213 63469244
Kidney transplant rejection 212.81 19.35 68 16497 4203 63468254
Polyomavirus-associated nephropathy 178.00 19.35 49 16516 1799 63470658
Pancytopenia 164.72 19.35 162 16403 96771 63375686
Cytomegalovirus infection reactivation 164.69 19.35 55 16510 3908 63468549
Immunosuppressant drug level increased 161.22 19.35 53 16512 3585 63468872
Agranulocytosis 147.27 19.35 88 16477 25046 63447411
Epstein-Barr virus infection 139.99 19.35 59 16506 7991 63464466
Cytomegalovirus gastrointestinal infection 129.99 19.35 27 16538 283 63472174
Smooth muscle cell neoplasm 127.69 19.35 32 16533 809 63471648
Transplant dysfunction 124.02 19.35 47 16518 4825 63467632
Cytomegalovirus colitis 123.26 19.35 39 16526 2333 63470124
Encephalitis cytomegalovirus 119.28 19.35 28 16537 533 63471924
Post transplant lymphoproliferative disorder 115.43 19.35 45 16520 4986 63467471
Delayed graft function 105.35 19.35 29 16536 1064 63471393
Blood creatinine increased 101.87 19.35 120 16445 87724 63384733
Nocardiosis 100.65 19.35 32 16533 1944 63470513
Lung transplant rejection 100.57 19.35 27 16538 900 63471557
Acute kidney injury 96.16 19.35 212 16353 263203 63209254
Lymphocele 94.35 19.35 25 16540 792 63471665
Complications of transplanted kidney 93.44 19.35 32 16533 2454 63470003
Posterior reversible encephalopathy syndrome 92.01 19.35 57 16508 17288 63455169
Cytomegalovirus chorioretinitis 91.18 19.35 29 16536 1764 63470693
Thrombotic microangiopathy 86.30 19.35 46 16519 10515 63461942
Fatigue 86.22 19.35 64 16501 887964 62584493
Arthralgia 85.10 19.35 22 16543 569688 62902769
Graft versus host disease 83.54 19.35 39 16526 6724 63465733
Bronchopulmonary aspergillosis 83.17 19.35 42 16523 8593 63463864
Renal transplant failure 81.76 19.35 22 16543 740 63471717
Renal tubular necrosis 81.24 19.35 46 16519 11832 63460625
Pneumocystis jirovecii pneumonia 80.75 19.35 52 16513 16862 63455595
Ureaplasma infection 80.35 19.35 21 16544 630 63471827
Nephropathy toxic 79.47 19.35 42 16523 9437 63463020
Pneumonia cytomegaloviral 77.40 19.35 27 16538 2187 63470270
Thrombocytopenia 77.11 19.35 140 16425 151017 63321440
Hyperammonaemia 73.51 19.35 33 16532 5199 63467258
Human ehrlichiosis 72.23 19.35 15 16550 157 63472300
Klebsiella infection 71.94 19.35 38 16527 8528 63463929
Strongyloidiasis 71.03 19.35 22 16543 1226 63471231
Escherichia infection 70.41 19.35 43 16522 12711 63459746
Cytomegalovirus test positive 69.25 19.35 27 16538 2991 63469466
Enterococcal infection 66.43 19.35 35 16530 7813 63464644
Pain 65.99 19.35 58 16507 740570 62731887
Renal transplant 64.76 19.35 21 16544 1359 63471098
Renal impairment 64.16 19.35 96 16469 88259 63384198
Scedosporium infection 63.93 19.35 17 16548 546 63471911
Adenovirus infection 61.50 19.35 26 16539 3545 63468912
Polyomavirus viraemia 59.46 19.35 17 16548 717 63471740
Transplant failure 58 19.35 20 16545 1565 63470892
Aspergillus infection 57.13 19.35 32 16533 8061 63464396
Lymphopenia 56.27 19.35 43 16522 18284 63454173
Neutrophil Pelger-Huet anomaly present 55.74 19.35 11 16554 87 63472370
Viraemia 53.62 19.35 18 16547 1298 63471159
Septic shock 53.60 19.35 76 16489 66553 63405904
Intentional product use issue 53.57 19.35 109 16456 127783 63344674
Sepsis 52.13 19.35 120 16445 153003 63319454
Fall 51.58 19.35 19 16546 392315 63080142
Peripheral swelling 51.36 19.35 5 16560 265937 63206520
Graft loss 50.73 19.35 13 16552 360 63472097
Myelosuppression 50.54 19.35 45 16520 23658 63448799
Joint swelling 50.09 19.35 12 16553 327654 63144803
Adenoviral hepatitis 49.80 19.35 13 16552 388 63472069
Bone marrow failure 49.74 19.35 49 16516 29241 63443216
Epstein-Barr virus infection reactivation 49.37 19.35 15 16550 783 63471674
Swelling 48.68 19.35 7 16558 275371 63197086
No adverse event 48.67 19.35 57 16508 41348 63431109
Liver transplant rejection 48.25 19.35 17 16548 1418 63471039
Pseudomonas infection 47.50 19.35 32 16533 11181 63461276
Systemic candida 47.29 19.35 21 16544 3224 63469233
Infusion related reaction 46.41 19.35 5 16560 245516 63226941
Hypersensitivity 46.17 19.35 10 16555 292675 63179782
Urosepsis 45.23 19.35 38 16527 18486 63453971
SARS-CoV-2 RNA increased 45.08 19.35 9 16556 76 63472381
Product use in unapproved indication 44.92 19.35 125 16440 178955 63293502
Pyelonephritis 44.50 19.35 37 16528 17741 63454716
Cytopenia 44.17 19.35 31 16534 11570 63460887
Toxoplasmosis 43.53 19.35 16 16549 1507 63470950
Mucormycosis 43.19 19.35 19 16546 2852 63469605
Hepatocellular injury 43.17 19.35 44 16521 27337 63445120
Abdominal discomfort 43.07 19.35 15 16550 320870 63151587
Dizziness 42.81 19.35 30 16535 429895 63042562
Anaemia 42.44 19.35 170 16395 293260 63179197
Pneumonia fungal 42.44 19.35 23 16542 5432 63467025
Adrenal mass 42.25 19.35 14 16551 970 63471487
Oesophageal candidiasis 41.63 19.35 23 16542 5640 63466817
Bacterial infection 41.53 19.35 37 16528 19462 63452995
Pericarditis constrictive 41.40 19.35 11 16554 352 63472105
Parvovirus B19 infection 41.09 19.35 12 16553 546 63471911
Cholestasis 40.53 19.35 44 16521 29390 63443067
Proteus infection 40.37 19.35 14 16551 1114 63471343
Cryptococcosis 40.02 19.35 14 16551 1143 63471314
Cytomegalovirus oesophagitis 39.70 19.35 10 16555 258 63472199
Venoocclusive liver disease 39.33 19.35 21 16544 4814 63467643
Weight increased 38.97 19.35 10 16555 260782 63211675
Multiple organ dysfunction syndrome 38.82 19.35 60 16505 56692 63415765
Alopecia 38.56 19.35 20 16545 337516 63134941
Cervicitis 37.74 19.35 11 16554 497 63471960
Drug hypersensitivity 37.63 19.35 17 16548 310670 63161787
Drug level increased 36.69 19.35 37 16528 22699 63449758
Acinetobacter infection 35.75 19.35 14 16551 1569 63470888
Pleural mesothelioma malignant 35.74 19.35 7 16558 53 63472404
JC virus infection 35.54 19.35 15 16550 2036 63470421
Brain abscess 35.08 19.35 15 16550 2103 63470354
Cystitis haemorrhagic 33.80 19.35 18 16547 4105 63468352
Pyrexia 33.80 19.35 224 16341 470254 63002203
Urinary tract infection 33.30 19.35 147 16418 264537 63207920
Systemic lupus erythematosus 33.21 19.35 7 16558 208911 63263546
Renal artery stenosis 33.21 19.35 14 16551 1895 63470562
Pain in extremity 33.15 19.35 23 16542 331463 63140994
Aplasia pure red cell 32.37 19.35 18 16547 4469 63467988
Escherichia urinary tract infection 32.26 19.35 26 16539 11936 63460521
Drug intolerance 31.41 19.35 21 16544 308640 63163817
Product dose omission issue 31.34 19.35 11 16554 234302 63238155
Superinfection bacterial 31.05 19.35 10 16555 633 63471824
Drug interaction 30.92 19.35 130 16435 229001 63243456
Ascites 30.61 19.35 45 16520 40683 63431774
Parainfluenzae virus infection 30.55 19.35 14 16551 2313 63470144
Urate nephropathy 30.51 19.35 7 16558 120 63472337
Rash 30.45 19.35 63 16502 560808 62911649
Human herpesvirus 8 infection 30.29 19.35 8 16557 250 63472207
Epstein-Barr virus associated lymphoproliferative disorder 30.01 19.35 13 16552 1881 63470576
Tonic clonic movements 29.99 19.35 12 16553 1423 63471034
Mesothelioma malignant 29.61 19.35 6 16559 55 63472402
Cytomegalovirus enteritis 29.34 19.35 8 16557 283 63472174
Eye infection toxoplasmal 29.23 19.35 8 16557 287 63472170
Venous haemorrhage 29.18 19.35 8 16557 289 63472168
Septal panniculitis 28.87 19.35 6 16559 63 63472394
Dyspnoea 28.32 19.35 84 16481 661229 62811228
Escherichia sepsis 27.94 19.35 17 16548 4990 63467467
Complications of transplant surgery 27.93 19.35 7 16558 177 63472280
Pancreatic pseudoaneurysm 27.70 19.35 6 16559 78 63472379
Cytomegalovirus gastritis 27.67 19.35 7 16558 184 63472273
Superinfection viral 27.65 19.35 5 16560 23 63472434
Urinary tract infection bacterial 27.58 19.35 17 16548 5105 63467352
Cytomegalovirus hepatitis 27.52 19.35 8 16557 358 63472099
Colon injury 27.49 19.35 7 16558 189 63472268
Reticulocytopenia 27.42 19.35 6 16559 82 63472375
Insomnia 27.29 19.35 11 16554 215241 63257216
Febrile neutropenia 27.07 19.35 80 16485 118369 63354088
Hyperuricaemia 26.84 19.35 17 16548 5353 63467104
Epstein-Barr viraemia 26.63 19.35 10 16555 1000 63471457
Hydronephrosis 26.29 19.35 22 16543 10640 63461817
Diabetes mellitus 26.28 19.35 50 16515 55760 63416697
Hepatic necrosis 25.95 19.35 17 16548 5670 63466787
Feeling abnormal 25.67 19.35 4 16561 148388 63324069
Back pain 25.51 19.35 19 16546 264126 63208331
Citrobacter infection 25.50 19.35 8 16557 465 63471992
Urticaria 25.45 19.35 6 16559 165796 63306661
Respiratory failure 25.41 19.35 71 16494 101787 63370670
Muscle spasms 25.29 19.35 5 16560 156145 63316312
Central nervous system fungal infection 25.09 19.35 6 16559 124 63472333
Infection reactivation 24.96 19.35 10 16555 1189 63471268
Acute graft versus host disease 24.62 19.35 15 16550 4413 63468044
Microsporidia infection 24.60 19.35 7 16558 290 63472167
Liver transplant 24.60 19.35 12 16553 2279 63470178
Oral candidiasis 24.51 19.35 30 16535 22768 63449689
Herpes simplex 24.50 19.35 19 16546 8252 63464205
Rhinovirus infection 24.30 19.35 15 16550 4514 63467943
Pancreas transplant rejection 24.12 19.35 6 16559 147 63472310
Pulmonary mucormycosis 23.81 19.35 7 16558 326 63472131
Herpes simplex viraemia 23.75 19.35 7 16558 329 63472128
Heart transplant rejection 23.44 19.35 8 16557 607 63471850
Graft versus host disease in gastrointestinal tract 23.37 19.35 13 16552 3228 63469229
Malaise 23.16 19.35 46 16519 415908 63056549
Renal lymphocele 23.08 19.35 5 16560 65 63472392
Herpes simplex oesophagitis 22.99 19.35 6 16559 179 63472278
Bacteriuria 22.68 19.35 9 16556 1044 63471413
Nasopharyngitis 22.42 19.35 20 16545 254237 63218220
Bacteraemia 22.26 19.35 25 16540 17323 63455134
Disseminated cryptococcosis 21.97 19.35 7 16558 428 63472029
Contusion 21.93 19.35 6 16559 150038 63322419
Respiratory tract infection viral 21.89 19.35 11 16554 2226 63470231
Pericarditis 21.76 19.35 4 16561 131575 63340882
Pneumonia influenzal 21.62 19.35 10 16555 1687 63470770
Pulmonary alveolar haemorrhage 21.41 19.35 14 16551 4654 63467803
Calciphylaxis 21.28 19.35 12 16553 3060 63469397
Escherichia bacteraemia 21.19 19.35 13 16552 3870 63468587
Glomerulonephritis 21.02 19.35 10 16555 1796 63470661
Viral mutation identified 21.00 19.35 10 16555 1800 63470657
Renal failure 20.99 19.35 73 16492 117579 63354878
Genital lesion 20.99 19.35 6 16559 253 63472204
Hypercalcaemia 20.86 19.35 31 16534 28291 63444166
Complications of transplanted lung 20.76 19.35 6 16559 263 63472194
Hepatic cyst infection 20.74 19.35 5 16560 107 63472350
Anorexia nervosa 20.74 19.35 6 16559 264 63472193
Headache 20.72 19.35 90 16475 633151 62839306
Haemolytic uraemic syndrome 20.72 19.35 11 16554 2492 63469965
Hypertensive emergency 20.63 19.35 10 16555 1872 63470585
Haematotoxicity 20.38 19.35 18 16547 9358 63463099
Asterixis 20.21 19.35 9 16556 1390 63471067
Herpes simplex reactivation 20.14 19.35 7 16558 561 63471896
Hyperkalaemia 20.11 19.35 44 16521 54159 63418298
Coronavirus infection 20.04 19.35 13 16552 4265 63468192
Nephrogenic diabetes insipidus 19.97 19.35 8 16557 951 63471506
Immunosuppressant drug level decreased 19.94 19.35 8 16557 955 63471502
Delayed engraftment 19.70 19.35 5 16560 133 63472324
Obliterative bronchiolitis 19.62 19.35 10 16555 2085 63470372
Epstein-Barr virus test positive 19.48 19.35 7 16558 618 63471839
Serum sickness 19.35 19.35 11 16554 2849 63469608

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 832.90 16.08 401 25739 25734 34905057
Cytomegalovirus viraemia 644.07 16.08 233 25907 7197 34923594
Leukopenia 512.38 16.08 403 25737 62453 34868338
Transplant rejection 462.84 16.08 201 25939 10110 34920681
Drug resistance 349.24 16.08 226 25914 25701 34905090
Polyomavirus-associated nephropathy 243.86 16.08 96 26044 3748 34927043
Pathogen resistance 238.18 16.08 124 26016 9358 34921433
Neutropenia 220.94 16.08 409 25731 156369 34774422
Kidney transplant rejection 208.46 16.08 105 26035 7392 34923399
Complications of transplanted kidney 197.46 16.08 87 26053 4522 34926269
Cytomegalovirus colitis 196.00 16.08 75 26065 2709 34928082
Off label use 188.36 16.08 712 25428 418812 34511979
Nocardiosis 183.67 16.08 79 26061 3872 34926919
Delayed graft function 175.10 16.08 65 26075 2156 34928635
BK virus infection 173.24 16.08 85 26055 5653 34925138
Cytomegalovirus chorioretinitis 161.06 16.08 70 26070 3519 34927272
Post transplant lymphoproliferative disorder 160.01 16.08 84 26056 6444 34924347
Transplant dysfunction 153.55 16.08 62 26078 2587 34928204
Pneumonia cytomegaloviral 151.67 16.08 64 26076 2990 34927801
Cytomegalovirus infection reactivation 146.15 16.08 73 26067 5045 34925746
Pancytopenia 142.28 16.08 255 25885 94902 34835889
Immunosuppressant drug level increased 134.57 16.08 73 26067 5982 34924809
Encephalitis cytomegalovirus 130.05 16.08 38 26102 580 34930211
Epstein-Barr virus infection 116.34 16.08 72 26068 7556 34923235
Immune reconstitution inflammatory syndrome 112.06 16.08 74 26066 8685 34922106
Aspergillus infection 111.38 16.08 84 26056 12170 34918621
Cytomegalovirus syndrome 110.84 16.08 24 26116 93 34930698
Mucormycosis 108.57 16.08 63 26077 5879 34924912
Agranulocytosis 108.24 16.08 110 26030 23711 34907080
Pulmonary nocardiosis 107.65 16.08 36 26104 872 34929919
Human ehrlichiosis 106.05 16.08 29 26111 343 34930448
Cytomegalovirus enteritis 105.92 16.08 31 26109 476 34930315
Malacoplakia 99.84 16.08 29 26111 433 34930358
Cytomegalovirus gastrointestinal infection 99.56 16.08 25 26115 206 34930585
Thrombotic microangiopathy 96.90 16.08 73 26067 10557 34920234
Cytomegalovirus test positive 95.21 16.08 50 26090 3836 34926955
Renal impairment 88.65 16.08 209 25931 94304 34836487
Pneumocystis jirovecii pneumonia 80.53 16.08 86 26054 19624 34911167
Nephropathy toxic 79.93 16.08 70 26070 12518 34918273
Septic shock 79.83 16.08 170 25970 71664 34859127
Escherichia infection 78.22 16.08 58 26082 8187 34922604
Lung transplant rejection 76.74 16.08 27 26113 765 34930026
Enterococcal infection 76.27 16.08 60 26080 9246 34921545
Lymphopenia 75.23 16.08 76 26064 16259 34914532
Fall 75.02 16.08 29 26111 202856 34727935
Enterovirus infection 74.59 16.08 28 26112 958 34929833
Cryptococcosis 73.50 16.08 36 26104 2383 34928408
Fatigue 72.79 16.08 103 26037 370550 34560241
Klebsiella infection 69.91 16.08 55 26085 8476 34922315
Renal artery stenosis 69.75 16.08 34 26106 2227 34928564
Liver transplant rejection 68.80 16.08 33 26107 2086 34928705
Rectal prolapse 68.38 16.08 22 26118 470 34930321
Bone marrow failure 67.97 16.08 96 26044 29157 34901634
Cytomegalovirus oesophagitis 67.77 16.08 22 26118 484 34930307
Renal cyst haemorrhage 66.59 16.08 23 26117 616 34930175
Myelosuppression 66.55 16.08 77 26063 19188 34911603
Mycobacterium avium complex infection 66.37 16.08 34 26106 2477 34928314
Pseudomonas infection 65.21 16.08 62 26078 12320 34918471
Trichophytosis 64.96 16.08 19 26121 291 34930500
Polyomavirus viraemia 64.87 16.08 25 26115 920 34929871
Intraductal papillary mucinous neoplasm 62.58 16.08 21 26119 514 34930277
Glomerulosclerosis 60.64 16.08 23 26117 810 34929981
Dermatophytosis 60.41 16.08 17 26123 225 34930566
Intentional product use issue 60.13 16.08 136 26004 59680 34871111
Pain 56.98 16.08 42 26098 204633 34726158
Vena cava injury 54.71 16.08 17 26123 323 34930468
Somnolence 54.19 16.08 9 26131 111107 34819684
Candida infection 53.29 16.08 66 26074 17649 34913142
Myocardial infarction 52.43 16.08 13 26127 121072 34809719
Focal segmental glomerulosclerosis 52.31 16.08 27 26113 1998 34928793
Viral load increased 52.10 16.08 29 26111 2498 34928293
Disseminated varicella zoster virus infection 51.44 16.08 16 26124 305 34930486
Bronchopulmonary aspergillosis 51.31 16.08 59 26081 14600 34916191
SARS-CoV-2 antibody test positive 51.01 16.08 17 26123 407 34930384
Product use in unapproved indication 50.97 16.08 198 25942 117301 34813490
Toxoplasmosis 50.48 16.08 23 26117 1293 34929498
Product dose omission issue 49.65 16.08 14 26126 119697 34811094
Parvovirus B19 infection 49.51 16.08 20 26120 835 34929956
Abdominal wall haemorrhage 48.60 16.08 17 26123 473 34930318
Cytopenia 47.58 16.08 53 26087 12670 34918121
Actinic keratosis 47.57 16.08 34 26106 4533 34926258
Large intestinal ulcer 47.28 16.08 25 26115 1944 34928847
Subcapsular renal haematoma 47.06 16.08 16 26124 408 34930383
Pain in extremity 46.85 16.08 18 26122 126495 34804296
Brain abscess 46.39 16.08 29 26111 3096 34927695
Pyelonephritis fungal 46.15 16.08 11 26129 71 34930720
Dizziness 45.54 16.08 58 26082 218463 34712328
Thrombocytopenia 44.93 16.08 233 25907 156014 34774777
Vascular anastomotic haemorrhage 44.71 16.08 14 26126 273 34930518
Kidney fibrosis 44.39 16.08 25 26115 2203 34928588
Squamous cell carcinoma of skin 43.59 16.08 47 26093 10834 34919957
Renal tubular necrosis 43.33 16.08 56 26084 15624 34915167
Fungal skin infection 43.07 16.08 26 26114 2608 34928183
Carotid arteriosclerosis 42.95 16.08 23 26117 1835 34928956
Granulomatous dermatitis 41.40 16.08 13 26127 256 34930535
Perineal cyst 41.26 16.08 13 26127 259 34930532
Syncope 41.20 16.08 9 26131 91442 34839349
Lymphocele 40.64 16.08 20 26120 1337 34929454
Pyrexia 39.03 16.08 400 25740 332613 34598178
Infection reactivation 38.77 16.08 20 26120 1478 34929313
Pericarditis fungal 38.72 16.08 11 26129 151 34930640
Clostridium difficile colitis 38.58 16.08 53 26087 15677 34915114
Pneumocystis jirovecii infection 38.38 16.08 21 26119 1749 34929042
Escherichia urinary tract infection 38.32 16.08 27 26113 3519 34927272
Transplant failure 38.27 16.08 27 26113 3526 34927265
Hyperparathyroidism secondary 37.91 16.08 20 26120 1548 34929243
Graft versus host disease 37.77 16.08 43 26097 10526 34920265
Pulmonary mucormycosis 37.52 16.08 16 26124 767 34930024
Renal tubular injury 37.14 16.08 17 26123 966 34929825
Vascular compression 37.12 16.08 13 26127 363 34930428
Rash 36.94 16.08 69 26071 222683 34708108
Constipation 36.94 16.08 29 26111 136953 34793838
Haemophagocytic lymphohistiocytosis 36.89 16.08 47 26093 12926 34917865
Cystitis haemorrhagic 36.89 16.08 32 26108 5647 34925144
JC virus infection 36.63 16.08 22 26118 2186 34928605
Dyspnoea 36.27 16.08 152 25988 376630 34554161
Arthralgia 35.54 16.08 45 26095 169996 34760795
Nausea 35.32 16.08 133 26007 339775 34591016
Renal transplant failure 35.23 16.08 17 26123 1089 34929702
Disseminated cytomegaloviral infection 35.11 16.08 11 26129 215 34930576
Strongyloidiasis 34.90 16.08 23 26117 2688 34928103
Aortic dilatation 34.24 16.08 18 26122 1383 34929408
Hepatic artery thrombosis 34.10 16.08 11 26129 237 34930554
Staphylococcal mediastinitis 33.92 16.08 8 26132 49 34930742
Liver transplant 33.84 16.08 22 26118 2512 34928279
Anxiety 33.84 16.08 16 26124 99412 34831379
Botulism 33.72 16.08 10 26130 161 34930630
Rhinovirus infection 33.68 16.08 27 26113 4272 34926519
Fungal endocarditis 33.20 16.08 12 26128 368 34930423
Malaise 33.12 16.08 55 26085 185770 34745021
Gastroenteritis Escherichia coli 32.69 16.08 12 26128 385 34930406
Depression 32.47 16.08 16 26124 97082 34833709
Staphylococcal infection 32.35 16.08 74 26066 32686 34898105
Tubulointerstitial nephritis 32.17 16.08 57 26083 20967 34909824
Cytomegalovirus nephritis 31.85 16.08 9 26131 121 34930670
Blood creatinine increased 31.80 16.08 148 25992 94828 34835963
Asthenia 31.69 16.08 87 26053 245164 34685627
Mean cell volume increased 31.65 16.08 23 26117 3146 34927645
Retinal scar 31.42 16.08 11 26129 307 34930484
Gene mutation 31.35 16.08 17 26123 1391 34929400
Feeling abnormal 31.09 16.08 5 26135 63230 34867561
Hyperparathyroidism 30.70 16.08 16 26124 1208 34929583
Cardiac failure congestive 30.56 16.08 12 26128 83258 34847533
Viraemia 30.53 16.08 16 26124 1222 34929569
Hypogammaglobulinaemia 30.25 16.08 33 26107 7707 34923084
Cell-mediated cytotoxicity 30.25 16.08 7 26133 39 34930752
Granulomatous rosacea 30.23 16.08 9 26131 147 34930644
Gastritis fungal 30.12 16.08 8 26132 84 34930707
Cytomegalovirus gastritis 30.02 16.08 10 26130 239 34930552
Cutaneous nocardiosis 29.63 16.08 9 26131 158 34930633
Blood 25-hydroxycholecalciferol decreased 29.27 16.08 10 26130 259 34930532
Steroid diabetes 29.18 16.08 19 26121 2176 34928615
Headache 29.15 16.08 67 26073 200568 34730223
Gastrointestinal haemorrhage 28.95 16.08 15 26125 88462 34842329
Chronic papillomatous dermatitis 28.75 16.08 7 26133 50 34930741
Disseminated trichosporonosis 28.40 16.08 7 26133 53 34930738
Renal tubular acidosis 28.23 16.08 19 26121 2300 34928491
Cerebral toxoplasmosis 28.17 16.08 17 26123 1704 34929087
Hepatosplenomegaly 28.11 16.08 24 26116 4145 34926646
Hyperhidrosis 27.62 16.08 11 26129 75681 34855110
Cytomegalovirus hepatitis 27.39 16.08 11 26129 452 34930339
Aplasia pure red cell 27.26 16.08 28 26112 6104 34924687
Malignant neoplasm progression 27.25 16.08 16 26124 88030 34842761
Muscle spasms 27.20 16.08 11 26129 74990 34855801
Progressive multifocal leukoencephalopathy 27.17 16.08 35 26105 9729 34921062
Intervertebral disc space narrowing 27.06 16.08 14 26126 1041 34929750
Glomerulonephropathy 27.03 16.08 9 26131 215 34930576
Scrotal ulcer 26.94 16.08 11 26129 472 34930319
Multiple organ dysfunction syndrome 26.88 16.08 121 26019 76445 34854346
Diverticulum intestinal 26.81 16.08 23 26117 3998 34926793
Fungal infection 26.73 16.08 45 26095 15890 34914901
Epstein-Barr virus infection reactivation 26.46 16.08 14 26126 1090 34929701
Proteus infection 26.44 16.08 14 26126 1092 34929699
Swelling of eyelid 26.38 16.08 14 26126 1097 34929694
Penile ulceration 26.06 16.08 11 26129 514 34930277
Back pain 25.67 16.08 32 26108 121757 34809034
Protothecosis 25.55 16.08 6 26134 36 34930755
Heart transplant rejection 25.03 16.08 14 26126 1217 34929574
Peripheral swelling 25.00 16.08 13 26127 76528 34854263
Joint swelling 24.82 16.08 7 26133 59883 34870908
Urticaria 24.57 16.08 8 26132 62369 34868422
Nasopharyngitis 24.20 16.08 11 26129 69957 34860834
Epstein-Barr viraemia 24.20 16.08 14 26126 1298 34929493
Odynophagia 24.16 16.08 25 26115 5496 34925295
Aortic arteriosclerosis 24.00 16.08 23 26117 4613 34926178
Isosporiasis 23.47 16.08 7 26133 115 34930676
End stage renal disease 23.47 16.08 31 26109 8830 34921961
Graft loss 23.46 16.08 12 26128 871 34929920
Neutropenic colitis 23.06 16.08 19 26121 3125 34927666
Oesophagopleural fistula 23.04 16.08 6 26134 58 34930733
Myocarditis toxoplasmal 23.04 16.08 6 26134 58 34930733
Gait disturbance 22.97 16.08 18 26122 85122 34845669
No adverse event 22.87 16.08 52 26088 22875 34907916
Drug intolerance 22.83 16.08 8 26132 59562 34871229
Therapeutic product effect incomplete 22.70 16.08 5 26135 50536 34880255
Type 3 diabetes mellitus 22.58 16.08 5 26135 22 34930769
Encephalitis viral 22.53 16.08 13 26127 1199 34929592
Organising pneumonia 22.51 16.08 25 26115 5954 34924837
Eye infection toxoplasmal 22.49 16.08 8 26132 234 34930557
Human polyomavirus infection 22.39 16.08 11 26129 733 34930058
Optic discs blurred 22.17 16.08 6 26134 68 34930723
Immunosuppressant drug level decreased 22.12 16.08 13 26127 1241 34929550
Epistaxis 22.03 16.08 8 26132 58243 34872548
Pneumonia necrotising 21.97 16.08 11 26129 763 34930028
Biloma 21.94 16.08 6 26134 71 34930720
Bacterial toxaemia 21.91 16.08 7 26133 146 34930645
Pruritus 21.77 16.08 46 26094 141935 34788856
Agitation 21.51 16.08 8 26132 57391 34873400
Acute kidney injury 21.32 16.08 333 25807 304655 34626136
Graft versus host disease in skin 21.32 16.08 20 26120 3905 34926886
Immune recovery uveitis 21.29 16.08 5 26135 30 34930761
Blood creatine phosphokinase increased 21.05 16.08 4 26136 44853 34885938
Toxic optic neuropathy 21.00 16.08 11 26129 839 34929952
Lung transplant 20.92 16.08 15 26125 2009 34928782
Haemolytic anaemia 20.87 16.08 32 26108 10447 34920344
Anastomotic stenosis 20.87 16.08 8 26132 290 34930501
Left ventricular hypertrophy 20.85 16.08 28 26112 8102 34922689
Posterior reversible encephalopathy syndrome 20.68 16.08 31 26109 9923 34920868
Electrocardiogram QT prolonged 20.67 16.08 3 26137 40949 34889842
Erythrophagocytosis 20.63 16.08 5 26135 35 34930756
Pneumonia fungal 20.62 16.08 26 26114 7074 34923717
Osteomyelitis chronic 20.54 16.08 8 26132 303 34930488
Drug hypersensitivity 20.52 16.08 18 26122 80511 34850280
Staphylococcal skin infection 20.48 16.08 11 26129 883 34929908
Periorbital cellulitis 20.44 16.08 8 26132 307 34930484
Renal tubular atrophy 20.28 16.08 12 26128 1160 34929631
Restless legs syndrome 20.26 16.08 28 26112 8326 34922465
Rhabdomyolysis 20.24 16.08 13 26127 68150 34862641
Cutaneous mucormycosis 20.21 16.08 7 26133 189 34930602
Muscular weakness 20.19 16.08 15 26125 72882 34857909
Oedematous kidney 20.15 16.08 5 26135 39 34930752
Bacteraemia 19.97 16.08 45 26095 19672 34911119
Thrombotic thrombocytopenic purpura 19.92 16.08 18 26122 3352 34927439
Dehiscence 19.88 16.08 6 26134 103 34930688
Sepsis 19.86 16.08 201 25939 166360 34764431
Genitourinary tract infection 19.82 16.08 6 26134 104 34930687
Blood pressure increased 19.79 16.08 22 26118 88080 34842711
Spinal stenosis 19.78 16.08 22 26118 5247 34925544
Abdominal discomfort 19.78 16.08 10 26130 59825 34870966
Chest discomfort 19.77 16.08 8 26132 54522 34876269
Drug level increased 19.73 16.08 48 26092 22048 34908743
Blood pressure decreased 19.60 16.08 7 26133 51508 34879283
Death 19.54 16.08 197 25943 397852 34532939
IVth nerve paralysis 19.46 16.08 6 26134 111 34930680
Pneumonia pseudomonal 19.44 16.08 19 26121 3903 34926888
Blood glucose increased 19.43 16.08 13 26127 66705 34864086
Haemolytic uraemic syndrome 19.29 16.08 15 26125 2271 34928520
Cytomegalovirus gastroenteritis 19.21 16.08 7 26133 220 34930571
Brain herniation 19.09 16.08 19 26121 3989 34926802
Prophylaxis against transplant rejection 19.04 16.08 5 26135 50 34930741
Bronchial anastomosis complication 19.02 16.08 4 26136 13 34930778
Hypersensitivity 19.01 16.08 11 26129 61024 34869767
Spinal osteoarthritis 19.01 16.08 26 26114 7657 34923134
Disseminated aspergillosis 19.00 16.08 10 26130 770 34930021
Neutrophilic dermatosis 18.88 16.08 7 26133 231 34930560
Serum sickness 18.81 16.08 14 26126 1986 34928805
Trichophytic granuloma 18.78 16.08 5 26135 53 34930738
Oliguria 18.71 16.08 27 26113 8353 34922438
Meningitis cryptococcal 18.62 16.08 15 26125 2389 34928402
Klebsiella sepsis 18.58 16.08 14 26126 2023 34928768
Urogenital infection bacterial 18.53 16.08 5 26135 56 34930735
Renal tubular disorder 18.50 16.08 20 26120 4623 34926168
Hydronephrosis 18.40 16.08 30 26110 10316 34920475
American trypanosomiasis 18.36 16.08 7 26133 250 34930541
Musculoskeletal stiffness 18.36 16.08 6 26134 46674 34884117
Necrotising retinitis 18.28 16.08 10 26130 832 34929959
Infectious pleural effusion 18.27 16.08 15 26125 2455 34928336
Cerebrovascular accident 18.16 16.08 22 26118 84789 34846002
Abscess 18.03 16.08 32 26108 11785 34919006
Erythema 18.00 16.08 24 26116 88756 34842035
Activated partial thromboplastin time prolonged 17.95 16.08 27 26113 8668 34922123
Fusarium infection 17.81 16.08 11 26129 1149 34929642
Contusion 17.59 16.08 3 26137 36361 34894430
Alpha haemolytic streptococcal infection 17.52 16.08 11 26129 1183 34929608
Graft infection 17.49 16.08 8 26132 454 34930337
Blastomycosis 17.45 16.08 8 26132 456 34930335
Acinetobacter infection 17.41 16.08 11 26129 1196 34929595
Retinal artery occlusion 17.29 16.08 13 26127 1872 34928919
Gastric fistula 17.19 16.08 5 26135 75 34930716
Herpes simplex 17.18 16.08 21 26119 5538 34925253
Inappropriate schedule of product administration 17.01 16.08 13 26127 62283 34868508
Lymphorrhoea 17.01 16.08 5 26135 78 34930713
Post procedural bile leak 16.94 16.08 7 26133 310 34930481
Clostridium colitis 16.83 16.08 11 26129 1268 34929523
Mycobacterium fortuitum infection 16.82 16.08 6 26134 177 34930614
Hypoglycaemia 16.80 16.08 10 26130 54630 34876161
Paraspinal abscess 16.61 16.08 5 26135 85 34930706
Granuloma 16.58 16.08 16 26124 3235 34927556
Morganella infection 16.55 16.08 8 26132 514 34930277
Therapeutic product effect decreased 16.51 16.08 3 26137 34740 34896051
Hirsutism 16.45 16.08 6 26134 189 34930602
Renal and pancreas transplant rejection 16.38 16.08 4 26136 29 34930762
Cutaneous malacoplakia 16.24 16.08 5 26135 92 34930699

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cytomegalovirus infection 1470.00 15.25 608 38248 42036 79663496
Cytomegalovirus viraemia 1082.97 15.25 354 38502 12467 79693065
Leukopenia 949.66 15.25 631 38225 115882 79589650
Transplant rejection 799.55 15.25 315 38541 19122 79686410
Drug resistance 727.15 15.25 372 38484 41841 79663691
Pathogen resistance 588.22 15.25 232 38624 14110 79691422
Neutropenia 452.46 15.25 625 38231 287085 79418447
Polyomavirus-associated nephropathy 405.75 15.25 138 38718 5489 79700043
Kidney transplant rejection 400.06 15.25 160 38696 10086 79695446
BK virus infection 355.98 15.25 141 38715 8663 79696869
Cytomegalovirus colitis 322.57 15.25 111 38745 4574 79700958
Complications of transplanted kidney 289.36 15.25 111 38745 6255 79699277
Cytomegalovirus infection reactivation 288.72 15.25 121 38735 8595 79696937
Immunosuppressant drug level increased 281.32 15.25 120 38736 8907 79696625
Delayed graft function 280.52 15.25 93 38763 3414 79702118
Pancytopenia 278.05 15.25 372 38484 165373 79540159
Nocardiosis 272.44 15.25 103 38753 5576 79699956
Post transplant lymphoproliferative disorder 266.17 15.25 124 38732 11340 79694192
Transplant dysfunction 255.22 15.25 105 38751 7116 79698416
Cytomegalovirus chorioretinitis 246.93 15.25 95 38761 5395 79700137
Encephalitis cytomegalovirus 239.85 15.25 64 38792 1086 79704446
Epstein-Barr virus infection 236.32 15.25 123 38733 14293 79691239
Agranulocytosis 229.57 15.25 184 38672 44846 79660686
Cytomegalovirus syndrome 224.35 15.25 47 38809 254 79705278
Pneumonia cytomegaloviral 216.42 15.25 84 38772 4885 79700647
Mucormycosis 210.34 15.25 96 38760 8373 79697159
Cytomegalovirus gastrointestinal infection 210.01 15.25 49 38807 463 79705069
Human ehrlichiosis 180.18 15.25 44 38812 513 79705019
Aspergillus infection 178.24 15.25 113 38743 19048 79686484
Off label use 178.21 15.25 891 37965 906324 78799208
Nephropathy toxic 169.24 15.25 112 38744 20307 79685225
Thrombotic microangiopathy 165.64 15.25 110 38746 20059 79685473
Pneumocystis jirovecii pneumonia 157.56 15.25 129 38727 32379 79673153
Fatigue 155.89 15.25 135 38721 929592 78775940
Renal impairment 155.45 15.25 277 38579 157506 79548026
Escherichia infection 152.17 15.25 100 38756 17917 79687615
Pain 148.86 15.25 79 38777 703723 79001809
Enterococcal infection 147.27 15.25 93 38763 15567 79689965
Lung transplant rejection 144.37 15.25 46 38810 1485 79704047
Klebsiella infection 141.96 15.25 91 38765 15629 79689903
Arthralgia 136.66 15.25 54 38802 571749 79133783
Septic shock 133.20 15.25 225 38631 122576 79582956
Polyomavirus viraemia 131.47 15.25 44 38812 1663 79703869
Cryptococcosis 130.98 15.25 53 38803 3440 79702092
Cytomegalovirus test positive 130.86 15.25 62 38794 5885 79699647
Bronchopulmonary aspergillosis 126.33 15.25 97 38759 22197 79683335
Pulmonary nocardiosis 126.14 15.25 40 38816 1271 79704261
Cytomegalovirus enteritis 122.22 15.25 35 38821 779 79704753
Lymphopenia 121.00 15.25 108 38748 30449 79675083
Fall 118.20 15.25 45 38811 487584 79217948
Smooth muscle cell neoplasm 116.44 15.25 35 38821 927 79704605
Pseudomonas infection 116.37 15.25 90 38766 20813 79684719
Immune reconstitution inflammatory syndrome 112.47 15.25 75 38781 13766 79691766
Renal tubular necrosis 112.27 15.25 95 38761 24944 79680588
Graft versus host disease 111.56 15.25 77 38779 14949 79690583
Bone marrow failure 111.54 15.25 131 38725 50976 79654556
Renal artery stenosis 110.83 15.25 47 38809 3435 79702097
Blood creatinine increased 106.41 15.25 234 38622 154823 79550709
Completed suicide 105.87 15.25 3 38853 245764 79459768
Thrombocytopenia 104.42 15.25 325 38531 264934 79440598
Malacoplakia 102.95 15.25 29 38827 607 79704925
Strongyloidiasis 102.53 15.25 46 38810 3852 79701680
Renal transplant failure 100.27 15.25 37 38819 1870 79703662
Acute kidney injury 98.48 15.25 506 38350 518898 79186634
Myelosuppression 97.57 15.25 109 38747 40187 79665345
Product use in unapproved indication 96.00 15.25 304 38552 250055 79455477
Toxoplasmosis 94.56 15.25 39 38817 2658 79702874
Lymphocele 93.52 15.25 34 38822 1647 79703885
Dizziness 93.48 15.25 72 38784 526369 79179163
Parvovirus B19 infection 90.10 15.25 32 38824 1448 79704084
Cytomegalovirus oesophagitis 89.19 15.25 27 38829 733 79704799
Posterior reversible encephalopathy syndrome 88.76 15.25 85 38771 26196 79679336
Joint swelling 87.92 15.25 17 38839 288629 79416903
Mycobacterium avium complex infection 86.29 15.25 43 38813 4557 79700975
Liver transplant rejection 84.38 15.25 38 38818 3210 79702322
Brain abscess 83.42 15.25 43 38813 4893 79700639
Pain in extremity 82.84 15.25 37 38819 364501 79341031
Cytopenia 80.61 15.25 72 38784 20311 79685221
Malaise 78.38 15.25 74 38782 489795 79215737
Peripheral swelling 77.76 15.25 18 38838 269599 79435933
Hypersensitivity 76.65 15.25 17 38839 262222 79443310
Product dose omission issue 76.61 15.25 14 38842 247523 79458009
Renal cyst haemorrhage 74.46 15.25 23 38833 669 79704863
Trichophytosis 73.32 15.25 20 38836 370 79705162
Ureaplasma infection 72.75 15.25 25 38831 1025 79704507
Headache 72.50 15.25 130 38726 653642 79051890
Rash 71.59 15.25 107 38749 578251 79127281
Transplant failure 71.50 15.25 38 38818 4603 79700929
Dyspnoea 70.97 15.25 200 38656 856825 78848707
Cystitis haemorrhagic 70.45 15.25 48 38808 9124 79696408
Drug intolerance 69.77 15.25 21 38835 264098 79441434
Nasopharyngitis 69.25 15.25 19 38837 253862 79451670
JC virus infection 69.04 15.25 35 38821 3846 79701686
Squamous cell carcinoma of skin 68.63 15.25 56 38800 13977 79691555
Epstein-Barr virus infection reactivation 68.51 15.25 28 38828 1864 79703668
Pyrexia 68.49 15.25 564 38292 678145 79027387
Infusion related reaction 67.13 15.25 15 38841 230222 79475310
Proteus infection 65.46 15.25 28 38828 2090 79703442
Anxiety 65.21 15.25 20 38836 248492 79457040
Actinic keratosis 64.73 15.25 39 38817 6003 79699529
Multiple organ dysfunction syndrome 64.57 15.25 165 38691 120081 79585451
Sepsis 64.42 15.25 281 38575 269147 79436385
Enterovirus infection 64.37 15.25 27 38829 1920 79703612
Drug hypersensitivity 63.82 15.25 33 38823 298883 79406649
Viraemia 63.39 15.25 30 38826 2839 79702693
Intraductal papillary mucinous neoplasm 63.17 15.25 21 38835 777 79704755
Nausea 63.02 15.25 247 38609 956949 78748583
Pyelonephritis fungal 62.89 15.25 16 38840 223 79705309
Pulmonary mucormycosis 62.71 15.25 23 38833 1142 79704390
Aplasia pure red cell 62.68 15.25 42 38814 7768 79697764
Viral load increased 62.62 15.25 30 38826 2918 79702614
Abdominal discomfort 62.58 15.25 22 38834 250705 79454827
Infection reactivation 62.47 15.25 29 38827 2628 79702904
Focal segmental glomerulosclerosis 62.16 15.25 31 38825 3290 79702242
Pneumonia fungal 61.81 15.25 48 38808 11162 79694370
Vena cava injury 61.31 15.25 17 38839 335 79705197
Therapeutic product effect decreased 61.06 15.25 5 38851 163858 79541674
Cytomegalovirus gastritis 60.98 15.25 18 38838 447 79705085
Hydronephrosis 59.97 15.25 57 38799 17397 79688135
Glomerulosclerosis 59.84 15.25 22 38834 1100 79704432
Candida infection 59.73 15.25 83 38773 38131 79667401
Adenovirus infection 59.69 15.25 42 38814 8405 79697127
Pyelonephritis 59.68 15.25 61 38795 20327 79685205
Somnolence 59.59 15.25 21 38835 238960 79466572
Feeling abnormal 58.93 15.25 5 38851 159194 79546338
Drug level increased 58.83 15.25 84 38772 39567 79665965
Graft loss 57.66 15.25 21 38835 1022 79704510
SARS-CoV-2 antibody test positive 57.60 15.25 17 38839 422 79705110
Renal transplant 57.41 15.25 27 38829 2520 79703012
Disseminated cytomegaloviral infection 56.28 15.25 17 38839 458 79705074
Dermatophytosis 56.21 15.25 17 38839 460 79705072
Escherichia urinary tract infection 54.99 15.25 49 38807 13776 79691756
Rhinovirus infection 54.94 15.25 39 38817 7914 79697618
Alopecia 54.89 15.25 22 38834 231333 79474199
Back pain 54.67 15.25 41 38815 304139 79401393
Fungal skin infection 54.63 15.25 35 38821 6001 79699531
Urticaria 54.11 15.25 12 38844 185189 79520343
Asthma 53.61 15.25 3 38853 135092 79570440
Acinetobacter infection 52.21 15.25 26 38830 2751 79702781
Subcapsular renal haematoma 51.89 15.25 18 38838 759 79704773
Musculoskeletal stiffness 51.82 15.25 11 38845 174997 79530535
Cytomegalovirus hepatitis 51.73 15.25 18 38838 766 79704766
Hypogammaglobulinaemia 51.71 15.25 46 38810 12905 79692627
Pericarditis fungal 51.51 15.25 13 38843 175 79705357
Haemophagocytic lymphohistiocytosis 51.03 15.25 58 38798 21779 79683753
Depression 50.80 15.25 21 38835 216769 79488763
Death 50.73 15.25 127 38729 566387 79139145
Vascular anastomotic haemorrhage 50.63 15.25 14 38842 273 79705259
Abdominal wall haemorrhage 49.94 15.25 17 38839 677 79704855
Granulomatous rosacea 49.72 15.25 13 38843 203 79705329
Muscle spasms 49.70 15.25 12 38844 174718 79530814
Eye infection toxoplasmal 49.64 15.25 16 38840 536 79704996
Contusion 49.18 15.25 7 38849 148769 79556763
Kidney fibrosis 49.04 15.25 27 38829 3508 79702024
Liver transplant 48.55 15.25 29 38827 4394 79701138
Epstein-Barr viraemia 48.55 15.25 23 38833 2182 79703350
Myocardial infarction 47.96 15.25 15 38841 184114 79521418
Weight increased 47.81 15.25 39 38817 277347 79428185
Disseminated varicella zoster virus infection 47.49 15.25 16 38840 617 79704915
Pericarditis constrictive 47.27 15.25 16 38840 626 79704906
Scedosporium infection 47.21 15.25 20 38836 1458 79704074
Perineal cyst 46.89 15.25 13 38843 256 79705276
Pruritus 45.92 15.25 76 38780 394572 79310960
Clostridium difficile colitis 45.86 15.25 67 38789 32216 79673316
Rectal prolapse 45.76 15.25 22 38834 2156 79703376
Staphylococcal infection 45.76 15.25 93 38763 58202 79647330
Graft versus host disease in skin 44.79 15.25 31 38825 6042 79699490
Fungal infection 44.55 15.25 76 38780 41672 79663860
Carotid arteriosclerosis 44.49 15.25 23 38833 2633 79702899
Steroid diabetes 43.80 15.25 25 38831 3481 79702051
Oesophageal candidiasis 43.43 15.25 36 38820 9182 79696350
Oesophageal atresia 42.62 15.25 10 38846 97 79705435
Viral mutation identified 41.58 15.25 25 38831 3833 79701699
Hyperammonaemia 41.53 15.25 38 38818 11055 79694477
Gene mutation 41.40 15.25 22 38834 2664 79702868
Left ventricular hypertrophy 41.24 15.25 38 38818 11153 79694379
Respiratory failure 41.16 15.25 186 38670 180725 79524807
Granulomatous dermatitis 41.15 15.25 13 38843 408 79705124
Haemolytic anaemia 41.08 15.25 47 38809 17773 79687759
Injection site pain 40.90 15.25 7 38849 129831 79575701
Herpes simplex 40.36 15.25 39 38817 12148 79693384
Heart transplant rejection 40.29 15.25 18 38838 1492 79704040
Serum sickness 40.14 15.25 24 38832 3642 79701890
Fungal endocarditis 40.14 15.25 14 38842 600 79704932
Intentional overdose 40.12 15.25 3 38853 105957 79599575
Hepatic artery thrombosis 40.02 15.25 12 38844 315 79705217
Tubulointerstitial nephritis 40.01 15.25 69 38787 38166 79667366
Pneumocystis jirovecii infection 39.86 15.25 22 38834 2872 79702660
Systemic candida 39.79 15.25 30 38826 6676 79698856
Encephalitis viral 39.40 15.25 21 38835 2558 79702974
Hyperparathyroidism secondary 38.79 15.25 21 38835 2639 79702893
Neutrophil Pelger-Huet anomaly present 38.66 15.25 12 38844 355 79705177
Anaemia 38.59 15.25 358 38498 444657 79260875
Cervicitis 38.53 15.25 11 38845 242 79705290
Cerebral toxoplasmosis 38.26 15.25 20 38836 2342 79703190
Gait disturbance 37.23 15.25 28 38828 207478 79498054
Staphylococcal mediastinitis 37.20 15.25 8 38848 50 79705482
Vascular compression 37.19 15.25 13 38843 561 79704971
Aortic dilatation 37.16 15.25 18 38838 1794 79703738
Systemic lupus erythematosus 37.14 15.25 7 38849 121142 79584390
Renal tubular injury 37.02 15.25 17 38839 1502 79704030
Discomfort 36.97 15.25 8 38848 125609 79579923
Swelling 36.67 15.25 31 38825 216680 79488852
Syncope 36.54 15.25 21 38835 179428 79526104
SARS-CoV-2 RNA increased 36.17 15.25 9 38847 114 79705418
Blood pressure increased 36.05 15.25 30 38826 211330 79494202
Central nervous system fungal infection 35.99 15.25 12 38844 448 79705084
Mobility decreased 35.51 15.25 8 38848 122167 79583365
Hyperkalaemia 35.05 15.25 129 38727 114269 79591263
Toxic optic neuropathy 34.83 15.25 15 38841 1138 79704394
Acute graft versus host disease 34.54 15.25 33 38823 10134 79695398
Adenoviral hepatitis 34.53 15.25 14 38842 913 79704619
Arthritis 34.45 15.25 7 38849 114873 79590659
Teratogenicity 34.16 15.25 10 38846 241 79705291
Cytomegalovirus nephritis 33.87 15.25 9 38847 150 79705382
Renal tubular atrophy 33.78 15.25 17 38839 1839 79703693
No adverse event 33.65 15.25 63 38793 37129 79668403
Loss of personal independence in daily activities 33.50 15.25 5 38851 102575 79602957
Haemolytic uraemic syndrome 33.49 15.25 23 38833 4426 79701106
Hyperhidrosis 33.40 15.25 16 38840 151476 79554056
Chest discomfort 32.93 15.25 13 38843 138031 79567501
Penile ulceration 32.81 15.25 11 38845 418 79705114
Scrotal ulcer 32.78 15.25 11 38845 419 79705113
Cell-mediated cytotoxicity 32.65 15.25 7 38849 43 79705489
Psoriasis 32.64 15.25 3 38853 89584 79615948
Progressive multifocal leukoencephalopathy 32.57 15.25 45 38811 20555 79684977
Graft versus host disease in gastrointestinal tract 32.42 15.25 26 38830 6330 79699202
Hyperuricaemia 32.19 15.25 34 38822 11765 79693767
Cytomegalovirus gastroenteritis 31.96 15.25 11 38845 453 79705079
Large intestinal ulcer 31.93 15.25 23 38833 4774 79700758
Cerebrovascular accident 31.86 15.25 18 38838 155274 79550258
Gastroenteritis Escherichia coli 31.85 15.25 12 38844 643 79704889
Migraine 31.69 15.25 3 38853 87490 79618042
Osteoarthritis 31.61 15.25 3 38853 87306 79618226
Constipation 31.53 15.25 56 38800 282994 79422538
Cutaneous nocardiosis 31.23 15.25 9 38847 205 79705327
Muscular weakness 31.06 15.25 20 38836 160709 79544823
Disseminated cryptococcosis 31.06 15.25 16 38840 1818 79703714
Superinfection bacterial 30.83 15.25 15 38841 1509 79704023
Colitis 30.80 15.25 92 38764 73215 79632317
Urosepsis 30.63 15.25 50 38806 26445 79679087
Oral candidiasis 30.38 15.25 53 38803 29575 79675957
Adrenal mass 30.26 15.25 14 38842 1259 79704273
Bacteraemia 30.19 15.25 56 38800 32768 79672764
Cardiac failure congestive 29.95 15.25 16 38840 142386 79563146
Hyperparathyroidism 29.94 15.25 19 38837 3205 79702327
Blood 25-hydroxycholecalciferol decreased 29.85 15.25 10 38846 379 79705153
Botulism 29.80 15.25 10 38846 381 79705151
Escherichia sepsis 29.64 15.25 28 38828 8480 79697052
Suicide attempt 29.63 15.25 3 38853 82929 79622603
Febrile neutropenia 29.38 15.25 203 38653 230796 79474736
Chronic papillomatous dermatitis 29.37 15.25 7 38849 73 79705459
Colon injury 29.33 15.25 9 38847 256 79705276
Hepatosplenomegaly 29.22 15.25 24 38832 6045 79699487
Blister 28.92 15.25 11 38845 119465 79586067
Retinal scar 28.91 15.25 10 38846 418 79705114
Glomerulonephritis 28.85 15.25 19 38837 3414 79702118
Donor specific antibody present 28.84 15.25 9 38847 271 79705261
Brain herniation 28.79 15.25 26 38830 7437 79698095
Prophylaxis against transplant rejection 28.63 15.25 7 38849 82 79705450
Mean cell volume increased 28.59 15.25 24 38832 6229 79699303
Palpitations 28.48 15.25 13 38843 126597 79578935
General physical health deterioration 28.42 15.25 57 38799 275181 79430351
Guillain-Barre syndrome 28.40 15.25 28 38828 8937 79696595
Sleep disorder 28.38 15.25 4 38852 85673 79619859
Hepatocellular injury 28.37 15.25 68 38788 47525 79658007
Therapeutic product effect incomplete 28.23 15.25 17 38839 141628 79563904
Odynophagia 28.03 15.25 31 38825 11296 79694236
Maternal exposure during pregnancy 27.76 15.25 16 38840 136522 79569010
Glomerulonephropathy 27.69 15.25 9 38847 310 79705222
Pneumonia pseudomonal 27.67 15.25 23 38833 5888 79699644
Gastritis fungal 27.44 15.25 8 38848 190 79705342
Stomatitis 27.36 15.25 19 38837 146738 79558794
Microsporidia infection 27.33 15.25 12 38844 954 79704578
Blastomycosis 27.27 15.25 11 38845 708 79704824
Dry mouth 27.16 15.25 5 38851 88014 79617518
Chest pain 27.03 15.25 61 38795 282243 79423289
Immunosuppressant drug level decreased 26.96 15.25 15 38841 1989 79703543
Mycobacterium fortuitum infection 26.61 15.25 8 38848 212 79705320
Clostridium difficile infection 26.54 15.25 62 38794 42623 79662909
Granuloma 26.44 15.25 26 38830 8271 79697261
Protothecosis 26.39 15.25 6 38850 50 79705482
Neutropenic colitis 26.29 15.25 22 38834 5685 79699847
Diabetes mellitus 26.23 15.25 91 38765 78299 79627233
Wheezing 26.21 15.25 12 38844 116652 79588880
Intervertebral disc space narrowing 26.15 15.25 14 38842 1721 79703811
End stage renal disease 26.11 15.25 31 38825 12189 79693343
Electrocardiogram QT prolonged 26.10 15.25 6 38850 90380 79615152
Meningitis cryptococcal 26.10 15.25 18 38838 3488 79702044
Abdominal pain upper 26.10 15.25 43 38813 223776 79481756
Memory impairment 25.88 15.25 11 38845 111723 79593809
Trichophytic granuloma 25.68 15.25 6 38850 57 79705475
Escherichia bacteraemia 25.59 15.25 23 38833 6539 79698993
Disseminated tuberculosis 25.46 15.25 19 38837 4164 79701368
Epstein-Barr virus test positive 25.44 15.25 12 38844 1127 79704405
Prostatitis 25.38 15.25 19 38837 4183 79701349
Venoocclusive liver disease 25.38 15.25 30 38826 11741 79693791
Asthenia 25.33 15.25 146 38710 511543 79193989
Inappropriate schedule of product administration 25.31 15.25 17 38839 133611 79571921
Flushing 25.21 15.25 6 38850 88262 79617270
Myocarditis toxoplasmal 25.14 15.25 6 38850 63 79705469
Infectious pleural effusion 25.03 15.25 18 38838 3726 79701806
Chronic graft versus host disease 24.94 15.25 23 38833 6758 79698774
Bacterial sepsis 24.85 15.25 25 38831 8173 79697359
Optic discs blurred 24.72 15.25 6 38850 68 79705464
Alpha haemolytic streptococcal infection 24.68 15.25 15 38841 2345 79703187
Disseminated trichosporonosis 24.65 15.25 7 38849 151 79705381
Pneumonia necrotising 24.59 15.25 12 38844 1215 79704317
Bacterial toxaemia 24.43 15.25 7 38849 156 79705376
Blood pressure decreased 24.33 15.25 9 38847 99457 79606075
Hypoaesthesia 24.30 15.25 31 38825 179321 79526211
Complications of transplanted lung 24.20 15.25 9 38847 465 79705067
Rhabdomyolysis 24.13 15.25 10 38846 103121 79602411
Graft infection 23.97 15.25 10 38846 701 79704831
Pancreatic pseudoaneurysm 23.97 15.25 6 38850 78 79705454
Pleural mesothelioma malignant 23.94 15.25 7 38849 168 79705364
Renal tubular disorder 23.85 15.25 22 38834 6464 79699068
Urate nephropathy 23.67 15.25 7 38849 175 79705357
Epstein-Barr virus associated lymphoproliferative disorder 23.66 15.25 17 38839 3515 79702017
Obliterative bronchiolitis 23.62 15.25 16 38840 3012 79702520
Chronic allograft nephropathy 23.54 15.25 13 38843 1698 79703834
Pancreas transplant rejection 23.54 15.25 8 38848 317 79705215
Isosporiasis 23.45 15.25 7 38849 181 79705351
Insomnia 23.45 15.25 53 38803 245117 79460415
Immune recovery uveitis 23.42 15.25 5 38851 30 79705502
Oliguria 23.38 15.25 34 38822 16275 79689257
Complications of transplant surgery 23.37 15.25 10 38846 747 79704785
Anaphylactic reaction 23.32 15.25 6 38850 83737 79621795
Oropharyngeal candidiasis 23.22 15.25 13 38843 1744 79703788
Wrong technique in product usage process 23.22 15.25 4 38852 73871 79631661
Dyspepsia 23.17 15.25 12 38844 108675 79596857
Venous haemorrhage 22.87 15.25 8 38848 346 79705186
Confusional state 22.80 15.25 79 38777 317918 79387614
Cutaneous mucormycosis 22.65 15.25 7 38849 204 79705328
Bacterial pyelonephritis 22.60 15.25 9 38847 560 79704972
Erythrophagocytosis 22.51 15.25 5 38851 37 79705495
Balance disorder 22.47 15.25 10 38846 98847 79606685
Benign prostatic hyperplasia 22.44 15.25 28 38828 11584 79693948
Urogenital infection bacterial 22.42 15.25 6 38850 103 79705429
Oxygen saturation decreased 22.39 15.25 18 38838 129029 79576503
Parainfluenzae virus infection 22.32 15.25 20 38836 5662 79699870
Organising pneumonia 22.14 15.25 27 38829 10912 79694620
Diverticulum intestinal 22.07 15.25 24 38832 8581 79696951
Superinfection viral 22.06 15.25 5 38851 41 79705491
Urinary tract infection bacterial 22.02 15.25 21 38835 6435 79699097
Lung transplant 21.88 15.25 18 38838 4543 79700989
Neck pain 21.79 15.25 5 38851 75412 79630120
Renal failure 21.77 15.25 170 38686 200798 79504734
Renal lymphocele 21.70 15.25 6 38850 117 79705415
Reticulocytopenia 21.62 15.25 7 38849 238 79705294
Necrotising retinitis 21.48 15.25 11 38845 1234 79704298
Epistaxis 21.37 15.25 14 38842 111501 79594031
Hepatic enzyme increased 21.36 15.25 35 38821 182575 79522957
Bacteriuria 21.27 15.25 11 38845 1260 79704272
Bacterial infection 21.18 15.25 47 38809 31233 79674299
Type 3 diabetes mellitus 21.17 15.25 5 38851 50 79705482
Acute respiratory distress syndrome 21.12 15.25 58 38798 44009 79661523
Renal tubular acidosis 21.07 15.25 16 38840 3598 79701934
Septal panniculitis 21.02 15.25 6 38850 132 79705400
Cytokine release syndrome 20.99 15.25 51 38805 35947 79669585
Oesophagopleural fistula 20.91 15.25 5 38851 53 79705479
Activated partial thromboplastin time prolonged 20.89 15.25 30 38826 14198 79691334
Paraesthesia 20.43 15.25 34 38822 176289 79529243
Delayed engraftment 20.41 15.25 7 38849 285 79705247
Post procedural urine leak 20.37 15.25 6 38850 148 79705384
Pneumonia klebsiella 20.27 15.25 18 38838 5036 79700496
Biloma 20.25 15.25 6 38850 151 79705381
Tonic clonic movements 20.17 15.25 13 38843 2251 79703281
Angioedema 20.14 15.25 6 38850 76029 79629503
Cytomegalovirus test negative 19.88 15.25 3 38853 0 79705532
Drug level fluctuating 19.87 15.25 9 38847 770 79704762
Agitation 19.82 15.25 12 38844 99703 79605829
Loss of consciousness 19.82 15.25 32 38824 167911 79537621
IVth nerve paralysis 19.78 15.25 6 38850 164 79705368
Human polyomavirus infection 19.75 15.25 10 38846 1096 79704436
Impaired healing 19.71 15.25 9 38847 87646 79617886
Ascites 19.71 15.25 81 38775 75481 79630051
Aortic arteriosclerosis 19.68 15.25 23 38833 8895 79696637
Disseminated aspergillosis 19.65 15.25 10 38846 1108 79704424
Pneumonia pneumococcal 19.51 15.25 16 38840 4021 79701511
Dehiscence 19.34 15.25 6 38850 177 79705355
Pneumonia cryptococcal 19.32 15.25 11 38845 1524 79704008
Meningitis viral 19.17 15.25 12 38844 1976 79703556
COVID-19 pneumonia 19.15 15.25 43 38813 28806 79676726
American trypanosomiasis 19.06 15.25 7 38849 349 79705183
Cytomegalovirus myocarditis 19.03 15.25 4 38852 22 79705510
Staphylococcal skin infection 19.00 15.25 11 38845 1573 79703959
Malignant neoplasm progression 18.95 15.25 23 38833 135967 79569565
Perinephric collection 18.81 15.25 7 38849 362 79705170
Immunosuppressant drug level 18.74 15.25 4 38852 24 79705508
Thyroid tuberculosis 18.74 15.25 4 38852 24 79705508
Cytomegalovirus enterocolitis 18.55 15.25 11 38845 1644 79703888
Suicidal ideation 18.52 15.25 7 38849 76333 79629199
Wound complication 18.49 15.25 17 38839 4976 79700556
Abscess 18.46 15.25 37 38819 22914 79682618
Drug interaction 18.31 15.25 294 38562 414889 79290643
Periorbital cellulitis 18.31 15.25 9 38847 926 79704606
Periostitis 18.03 15.25 8 38848 652 79704880
Adverse drug reaction 18.02 15.25 5 38851 66387 79639145
Viral uveitis 18.01 15.25 5 38851 99 79705433
Ill-defined disorder 17.81 15.25 5 38851 65870 79639662
Enterobacter infection 17.81 15.25 16 38840 4546 79700986
Mesothelioma malignant 17.79 15.25 6 38850 232 79705300
Erythema 17.72 15.25 53 38803 223237 79482295
Post procedural bile leak 17.71 15.25 7 38849 427 79705105
Parvovirus infection 17.66 15.25 8 38848 685 79704847
Osteomyelitis chronic 17.54 15.25 8 38848 696 79704836
Fusarium infection 17.52 15.25 11 38845 1821 79703711
Pericarditis 17.51 15.25 15 38841 104221 79601311
Bicytopenia 17.48 15.25 16 38840 4654 79700878
Herpes simplex viraemia 17.45 15.25 7 38849 444 79705088
Retinal detachment 17.40 15.25 22 38834 9225 79696307
Anorexia nervosa 17.37 15.25 6 38850 250 79705282
Sinusitis 17.31 15.25 44 38812 195457 79510075
Hepatitis viral 17.26 15.25 9 38847 1049 79704483
Pneumonia influenzal 17.25 15.25 13 38843 2891 79702641
Medication error 17.15 15.25 6 38850 68636 79636896
Cutaneous malacoplakia 17.14 15.25 5 38851 119 79705413
Oesophageal ulcer 17.10 15.25 19 38837 6956 79698576
Herpes simplex reactivation 17.04 15.25 7 38849 472 79705060
Scopulariopsis infection 17.02 15.25 5 38851 122 79705410
Diffuse large B-cell lymphoma 16.94 15.25 25 38831 12124 79693408
Oesophagogastroscopy normal 16.59 15.25 3 38853 6 79705526
Hypervolaemia 16.46 15.25 52 38804 42638 79662894
Pulmonary interstitial emphysema syndrome 16.45 15.25 7 38849 516 79705016
Adenoviral haemorrhagic cystitis 16.42 15.25 7 38849 518 79705014
Anastomotic stenosis 16.41 15.25 7 38849 519 79705013
Renal and pancreas transplant rejection 16.35 15.25 4 38852 47 79705485
Heart rate increased 16.21 15.25 21 38835 120703 79584829
Cholestasis 16.15 15.25 59 38797 52050 79653482
Swelling of eyelid 16.14 15.25 14 38842 3797 79701735
Blood creatine phosphokinase increased 16.13 15.25 6 38850 66084 79639448
Dysgeusia 16.10 15.25 4 38852 57173 79648359
Type 2 diabetes mellitus 16.08 15.25 4 38852 57118 79648414
Klebsiella sepsis 15.95 15.25 13 38843 3239 79702293
Hypercalcaemia 15.92 15.25 48 38808 38382 79667150
Helicobacter infection 15.92 15.25 7 38849 69697 79635835
Retinal artery occlusion 15.80 15.25 13 38843 3281 79702251
Musculoskeletal pain 15.70 15.25 16 38840 102338 79603194
Neutrophilic dermatosis 15.64 15.25 7 38849 583 79704949
Intentional product misuse 15.62 15.25 14 38842 95151 79610381
Human herpesvirus 6 infection 15.59 15.25 16 38840 5354 79700178
Pseudomembranous colitis 15.58 15.25 16 38840 5358 79700174
Bronchial anastomosis complication 15.57 15.25 4 38852 58 79705474
Polycystic liver disease 15.50 15.25 5 38851 168 79705364
Gastroenteritis 15.49 15.25 44 38812 34038 79671494
Unevaluable event 15.44 15.25 4 38852 55581 79649951
Blood glucose increased 15.44 15.25 20 38836 114955 79590577
Disturbance in attention 15.43 15.25 3 38853 50798 79654734
Hepatic cyst infection 15.41 15.25 5 38851 171 79705361
Corynebacterium infection 15.28 15.25 9 38847 1329 79704203

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AB14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175461 Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
CHEBI has role CHEBI:36044 antiviral drugs
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Congenital cytomegalovirus infection indication 59527008
CMV Retinitis in AIDS Patients indication
Prevention of CMV Disease After Kidney-Pancreas Transplantation indication
Prevention of CMV Disease After Cardiac Transplantation indication
Prevention of CMV Disease After Kidney Transplantation indication
Prevention of Cytomegalovirus Disease off-label use
Dehydration contraindication 34095006
Acute nephropathy contraindication 58574008
Kidney disease contraindication 90708001 DOID:557
Anemia contraindication 271737000 DOID:2355
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449
Breastfeeding (mother) contraindication 413712001
Granulocytopenic disorder contraindication 417672002
Severe Bone Marrow Depression contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 11.83 acidic
pKa3 7.81 Basic
pKa4 3.68 Basic
pKa5 2.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA polymerase catalytic subunit Enzyme INHIBITOR DRUGBANK CHEMBL

External reference:

IDSource
4021263 VUID
N0000148704 NUI
D02495 KEGG_DRUG
4021263 VANDF
4021264 VANDF
4030204 VANDF
C0909381 UMLSCUI
CHEBI:63635 CHEBI
CHEMBL1201314 ChEMBL_ID
CHEMBL252321 ChEMBL_ID
CHEMBL400177 ChEMBL_ID
DB01610 DRUGBANK_ID
CHEMBL1200454 ChEMBL_ID
D000077562 MESH_DESCRIPTOR_UI
135413535 PUBCHEM_CID
4716 IUPHAR_LIGAND_ID
7650 INN_ID
GCU97FKN3R UNII
275891 RXNORM
15960 MMSL
231338 MMSL
d04755 MMSL
009135 NDDF
009136 NDDF
129476000 SNOMEDCT_US
395266000 SNOMEDCT_US
412326001 SNOMEDCT_US
175865-60-8 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Valcyte HUMAN PRESCRIPTION DRUG LABEL 1 0004-0038 TABLET, FILM COATED 450 mg ORAL NDA 31 sections
Valcyte HUMAN PRESCRIPTION DRUG LABEL 1 0004-0038 TABLET, FILM COATED 450 mg ORAL NDA 31 sections
Valcyte HUMAN PRESCRIPTION DRUG LABEL 1 0004-0039 POWDER, FOR SOLUTION 50 mg ORAL NDA 31 sections
Valcyte HUMAN PRESCRIPTION DRUG LABEL 1 0004-0039 POWDER, FOR SOLUTION 50 mg ORAL NDA 31 sections
Valganciclovir hydrochloride for Oral HUMAN PRESCRIPTION DRUG LABEL 1 0591-2579 POWDER, FOR SOLUTION 50 mg ORAL ANDA 29 sections
Valganciclovir hydrochloride for Oral HUMAN PRESCRIPTION DRUG LABEL 1 0591-2579 POWDER, FOR SOLUTION 50 mg ORAL ANDA 29 sections
Valganciclovir hydrochloride for Oral HUMAN PRESCRIPTION DRUG LABEL 1 0591-2579 POWDER, FOR SOLUTION 50 mg ORAL ANDA 29 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 0603-6330 TABLET, FILM COATED 450 mg ORAL ANDA 32 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 0904-6796 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 16714-765 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir Human Prescription Drug Label 1 27241-158 TABLET 450 mg ORAL ANDA 28 sections
Valganciclovir hydrochloride Human Prescription Drug Label 1 27241-159 POWDER, FOR SOLUTION 50 mg ORAL ANDA 28 sections
Valganciclovir Human Prescription Drug Label 1 31722-832 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
VALGANCICLOVIR HUMAN PRESCRIPTION DRUG LABEL 1 31722-837 POWDER, FOR SOLUTION 50 mg ORAL ANDA 27 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 42291-875 TABLET, FILM COATED 450 mg ORAL ANDA 29 sections
valganciclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43598-356 TABLET 450 mg ORAL ANDA 28 sections
valganciclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43598-356 TABLET 450 mg ORAL ANDA 28 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 48433-124 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 50268-787 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 55111-762 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir Human Prescription Drug Label 1 59651-444 FOR SOLUTION 50 mg ORAL ANDA 28 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 60429-846 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 60429-846 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 60687-765 POWDER, FOR SOLUTION 50 mg ORAL ANDA 29 sections
Valcyte HUMAN PRESCRIPTION DRUG LABEL 1 61269-480 TABLET, FILM COATED 450 mg ORAL NDA 31 sections
Valcyte HUMAN PRESCRIPTION DRUG LABEL 1 61269-485 POWDER, FOR SOLUTION 50 mg ORAL NDA 31 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 63629-2288 TABLET, FILM COATED 450 mg ORAL ANDA 31 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 63629-2288 TABLET, FILM COATED 450 mg ORAL ANDA 31 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 63739-076 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections
Valganciclovir HUMAN PRESCRIPTION DRUG LABEL 1 63739-076 TABLET, FILM COATED 450 mg ORAL ANDA 26 sections