All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

vidarabine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
arabinofuranosyl derivatives	2818	5536-17-4

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: vidarabine anhydrous vidarabine adenine arabinoside araadenosine arabinosyladenine vidarabin

A nucleoside antibiotic isolated from Streptomyces antibioticus. It has some antineoplastic properties and has broad spectrum activity against DNA viruses in cell cultures and significant antiviral activity against infections caused by a variety of viruses such as the herpes viruses, the VACCINIA VIRUS and varicella zoster virus. Molecular weight: 267.25 Formula: C10H13N5O4 CLOGP: -1.36 LIPINSKI: 0 HAC: 9 HDO: 4 TPSA: 139.54 ALOGS: -1.28 ROTB: 2 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.70	g	P

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	0 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
Nov. 26, 1976	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic encephalopathy	44.10	41.35	10	308	11430	79732640

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J05AB03	ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Nucleosides and nucleotides excl. reverse transcriptase inhibitors
ATC	S01AD06	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Antivirals
CHEBI has role	CHEBI:35610	antineoplastic agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000963	Antimetabolites
MeSH PA	D000998	Antiviral Agents
MeSH PA	D009676	Noxae

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Herpes simplex keratitis	indication	9389005
Herpes simplex dendritic keratitis	indication	29943008

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.67	acidic
pKa2	12.33	acidic
pKa3	13.34	acidic
pKa4	3.95	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Deoxycytidine kinase	Kinase	P27707	DCK_HUMAN					WOMBAT-PK
DNA polymerase alpha catalytic subunit	Enzyme	P09884	DPOLA_HUMAN					WOMBAT-PK
Ribonucleoside-diphosphate reductase large subunit	Enzyme	P23921	RIR1_HUMAN					WOMBAT-PK
Ribonucleoside-diphosphate reductase subunit M2	Enzyme	P31350	RIR2_HUMAN					WOMBAT-PK
Deoxyguanosine kinase, mitochondrial	Kinase	Q16854	DGUOK_HUMAN					WOMBAT-PK
Ribose-phosphate pyrophosphokinase 1	Kinase	P60891	PRPS1_HUMAN					WOMBAT-PK
Dipeptidyl peptidase 4	Enzyme	P27487	DPP4_HUMAN		IC50	7.21		CHEMBL
DNA polymerase catalytic subunit	Enzyme		DPOL_HHV11	INHIBITOR				CHEMBL	CHEMBL
Adenylate cyclase type V	Enzyme		ADCY5_RAT		IC50	4.09		CHEMBL
Adenosylhomocysteinase	Enzyme		SAHH_MOUSE		Ki	4.52		CHEMBL

External reference:

ID	Source
4018650	VUID
N0000146963	NUI
D00406	KEGG_DRUG
4018650	VANDF
C0042646	UMLSCUI
CHEBI:45327	CHEBI
RAB	PDB_CHEM_ID
CHEMBL1090	ChEMBL_ID
DB00194	DRUGBANK_ID
D014740	MESH_DESCRIPTOR_UI
21704	PUBCHEM_CID
4806	IUPHAR_LIGAND_ID
FA2DM6879K	UNII
11194	RXNORM
5673	MMSL
003014	NDDF
37306000	SNOMEDCT_US
373759007	SNOMEDCT_US
2842	INN_ID
24356-66-9	SECONDARY_CAS_RN

Pharmaceutical products:

None