toloxatone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 2702 | 29218-27-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
oxazolidinone derivative; psychotropic drug; structure
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 56 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 1.50 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 11 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.49 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 1.60 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Phaeochromocytoma | 30.99 | 24.60 | 3 | 3 | 516 | 63488500 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Phaeochromocytoma | 30.92 | 22.86 | 3 | 3 | 664 | 79743718 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N06AG03 | NERVOUS SYSTEM PSYCHOANALEPTICS ANTIDEPRESSANTS Monoamine oxidase A inhibitors |
| MeSH PA | D000928 | Antidepressive Agents |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D008996 | Monoamine Oxidase Inhibitors |
| MeSH PA | D011619 | Psychotropic Drugs |
| CHEBI has role | CHEBI:35469 | antidepressants |
| CHEBI has role | CHEBI:38623 | monoamine oxidase inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Depressive disorder | indication | 35489007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.77 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Amine oxidase [flavin-containing] A | Enzyme | INHIBITOR | Ki | 5.82 | CHEMBL | SCIENTIFIC LITERATURE | |||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 4.82 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 6.42 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 6.42 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 4.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D02559 | KEGG_DRUG |
| C0076804 | UMLSCUI |
| CHEBI:134870 | CHEBI |
| CHEMBL18116 | ChEMBL_ID |
| DB09245 | DRUGBANK_ID |
| 34521 | PUBCHEM_CID |
| C010798 | MESH_SUPPLEMENTAL_RECORD_UI |
| 3429 | INN_ID |
| 5T206015T5 | UNII |
| 38382 | RXNORM |
| 005364 | NDDF |
Pharmaceutical products:
None