moclobemide indications/contra

Stem definitionDrug idCAS RN
1825 71320-77-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • moclobamide
  • moclobemide
  • auromid
  • aurorix
  • moclaime
A reversible inhibitor of monoamine oxidase type A (RIMA) that has antidepressive properties.
  • Molecular weight: 268.74
  • Formula: C13H17ClN2O2
  • CLOGP: 2.17
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 41.57
  • ALOGS: -2.38
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.30 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1990 YEAR INTRODUCED

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Serotonin syndrome 169.77 156.79 26 46 5397 3380390

Pharmacologic Action:

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SourceCodeDescription
ATC N06AG02 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Monoamine oxidase A inhibitors
CHEBI has role CHEBI:35469 antidepressant
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D008996 Monoamine Oxidase Inhibitors
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Depressive disorder indication 35489007 DOID:2848

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.45 acidic
pKa2 6.83 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Amine oxidase [flavin-containing] A Enzyme INHIBITOR Ki 8.30 CHEMBL IUPHAR
Amine oxidase [flavin-containing] B Enzyme Ki 5.97 CHEMBL
5-hydroxytryptamine receptor 1A GPCR Kd 5.30 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 4.10 CHEMBL
Amine oxidase [flavin-containing] A Enzyme Ki 4.94 CHEMBL
Amine oxidase [flavin-containing] A Enzyme Ki 8.30 CHEMBL
Amine oxidase [flavin-containing] B Enzyme Ki 5.97 CHEMBL

External reference:

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IDSource
N0000166883 NUI
C0066673 UMLSCUI
7428 IUPHAR_LIGAND_ID
D02561 KEGG_DRUG
4235 PUBCHEM_CID
N0000166883 NDFRT
004179 NDDF
30121 RXNORM
321911007 SNOMEDCT_US
395800003 SNOMEDCT_US
CHEMBL86304 ChEMBL_ID
CHEBI:83531 CHEBI
DB01171 DRUGBANK_ID
PJ0Y7AZB63 UNII
4914 INN_ID
D020912 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None