pantoprazole Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 2054 102625-70-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pantoprazole
  • pantozol
  • pantoprazole sodium
  • controloc control
  • pantoprazole sodium hydrate
  • pantoprazole sodium sesquihydrate
Pantoprazole sodium is a proton pump inhibitor (PPI) that suppresses the final step in gastric acid production by covalently binding to the (H+, K+)-ATPase enzyme system at the secretory surface of the gastric parietal cell. This effect leads to inhibition of both basal and stimulated gastric acid secretion, irrespective of the stimulus. The binding to the (H+, K+)-ATPase results in a duration of antisecretory effect that persists longer than 24 hours.
  • Molecular weight: 383.37
  • Formula: C16H15F2N3O4S
  • CLOGP: 2.11
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 86.33
  • ALOGS: -2.89
  • ROTB: 7

Drug dosage:

DoseUnitRoute
40 mg O
40 mg P

Approvals:

DateAgencyCompanyOrphan
Feb. 2, 2000 FDA WYETH PHARMS INC

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypomagnesaemia 994.97 23.60 223 5726 3479 3376431
Drug interaction 582.92 23.60 270 5679 46542 3333368
Hypocalcaemia 574.28 23.60 157 5792 5664 3374246
Drug hypersensitivity 569.48 23.60 245 5704 35435 3344475
Hyponatraemia 454.14 23.60 173 5776 18186 3361724
Suicide attempt 386.93 23.60 148 5801 15699 3364211
Acute kidney injury 368.11 23.60 202 5747 49481 3330429
Drug ineffective 335.20 23.60 261 5688 115829 3264081
Diarrhoea 335.06 23.60 250 5699 104098 3275812
Vomiting 313.11 23.60 226 5723 89305 3290605
Nausea 303.57 23.60 258 5691 129387 3250523
Tubulointerstitial nephritis 299.99 23.60 89 5860 4297 3375613
Agranulocytosis 287.36 23.60 90 5859 5222 3374688
Toxic epidermal necrolysis 283.93 23.60 86 5863 4459 3375451
Hypokalaemia 263.45 23.60 108 5841 13697 3366213
Subacute cutaneous lupus erythematosus 259.39 23.60 49 5900 299 3379611
Drug reaction with eosinophilia and systemic symptoms 256.16 23.60 91 5858 7804 3372106
Pruritus 254.81 23.60 156 5793 46677 3333233
Thrombocytopenia 248.60 23.60 139 5810 35129 3344781
Dyspnoea 224.32 23.60 197 5752 102737 3277173
Stevens-Johnson syndrome 223.23 23.60 79 5870 6693 3373217
Hypotension 222.02 23.60 146 5803 49368 3330542
Drug screen positive 217.95 23.60 58 5891 1870 3378040
Gastrooesophageal reflux disease 194.52 23.60 83 5866 11608 3368302
Asthenia 184.94 23.60 146 5803 65519 3314391
Abdominal pain 184.79 23.60 127 5822 46098 3333812
Drug screen false positive 183.66 23.60 40 5909 534 3379376
Product substitution issue 181.62 23.60 70 5879 7530 3372380
Condition aggravated 181.34 23.60 118 5831 39115 3340795
Leukopenia 179.56 23.60 86 5863 15737 3364173
Jaundice 178.93 23.60 75 5874 10032 3369878
Dyspepsia 176.71 23.60 78 5871 11834 3368076
Pancytopenia 171.19 23.60 88 5861 18732 3361178
Intentional overdose 170.47 23.60 82 5867 15143 3364767
Dizziness 169.43 23.60 148 5801 76364 3303546
Completed suicide 157.12 23.60 99 5850 31015 3348895
Erythema 156.42 23.60 96 5853 28714 3351196
Somnolence 151.52 23.60 98 5851 32106 3347804
Abdominal pain upper 148.07 23.60 88 5861 24828 3355082
Hepatocellular injury 147.54 23.60 52 5897 4343 3375567
Rash 146.74 23.60 132 5817 70689 3309221
Pyrexia 146.48 23.60 140 5809 80975 3298935
Confusional state 146.09 23.60 102 5847 37896 3342014
Fall 144.68 23.60 121 5828 58762 3321148
Gamma-glutamyltransferase increased 142.57 23.60 62 5887 9066 3370844
Clostridium difficile colitis 142.15 23.60 46 5903 2957 3376953
Electrocardiogram QT prolonged 141.96 23.60 65 5884 10730 3369180
Malaise 139.98 23.60 124 5825 65053 3314857
Cholestasis 137.69 23.60 52 5897 5285 3374625
Hypoparathyroidism 136.30 23.60 26 5923 168 3379742
Chest pain 133.93 23.60 99 5850 40176 3339734
Renal failure 132.63 23.60 91 5858 32849 3347061
Fatigue 127.33 23.60 148 5801 107092 3272818
Hepatitis cholestatic 127.13 23.60 38 5911 1875 3378035
Rash maculo-papular 122.40 23.60 49 5900 5818 3374092
Paraesthesia 120.17 23.60 80 5869 27468 3352442
Pain 118.74 23.60 118 5831 71439 3308471
Angioedema 118.32 23.60 64 5885 15071 3364839
Anaemia 117.82 23.60 104 5845 54229 3325681
Clostridium test positive 115.21 23.60 27 5922 509 3379401
Alanine aminotransferase increased 113.71 23.60 73 5876 23567 3356343
Eosinophilia 113.22 23.60 44 5905 4829 3375081
Hepatic enzyme increased 113.20 23.60 60 5889 13565 3366345
Tetany 111.92 23.60 27 5922 579 3379331
Rash erythematous 111.16 23.60 50 5899 7912 3371998
Abdominal distension 110.57 23.60 59 5890 13517 3366393
Inappropriate antidiuretic hormone secretion 110.20 23.60 39 5910 3293 3376617
Weight decreased 110.09 23.60 88 5861 40023 3339887
Hepatitis 108.14 23.60 52 5897 9573 3370337
Clostridium difficile infection 107.70 23.60 38 5911 3180 3376730
Muscle spasms 107.48 23.60 74 5875 26829 3353081
Toxic skin eruption 102.27 23.60 36 5913 2992 3376918
Neutropenia 101.87 23.60 78 5871 33308 3346602
Arthralgia 98.37 23.60 99 5850 60762 3319148
Brain injury 94.97 23.60 29 5920 1538 3378372
Drug-induced liver injury 93.97 23.60 39 5910 5074 3374836
Liver injury 92.90 23.60 35 5914 3529 3376381
General physical health deterioration 92.66 23.60 61 5888 20528 3359382
Urticaria 91.78 23.60 69 5880 28658 3351252
Aspartate aminotransferase increased 91.26 23.60 61 5888 21052 3358858
Disorientation 88.29 23.60 46 5903 10033 3369877
Rhabdomyolysis 86.74 23.60 53 5896 15676 3364234
Overdose 85.70 23.60 71 5878 33907 3346003
Hypersensitivity 84.68 23.60 65 5884 27835 3352075
Toxicity to various agents 82.39 23.60 80 5869 46974 3332936
Atrial fibrillation 82.05 23.60 60 5889 23881 3356029
Loss of consciousness 79.83 23.60 63 5886 28084 3351826
Pruritus generalised 79.18 23.60 36 5913 5833 3374077
Headache 78.77 23.60 108 5841 91872 3288038
Multiple organ dysfunction syndrome 78.03 23.60 48 5901 14362 3365548
Blood alkaline phosphatase increased 77.94 23.60 43 5906 10510 3369400
Drug abuse 76.90 23.60 52 5897 18278 3361632
Haemoglobin decreased 75.75 23.60 63 5886 30231 3349679
Urinary incontinence 75.23 23.60 35 5914 5977 3373933
Acute generalised exanthematous pustulosis 74.88 23.60 26 5923 2073 3377837
Transaminases increased 74.01 23.60 36 5913 6788 3373122
Hyperhidrosis 73.81 23.60 56 5893 23554 3356356
Tremor 73.44 23.60 60 5889 28084 3351826
Pancreatitis 70.95 23.60 45 5904 14200 3365710
Hypertension 70.32 23.60 67 5882 38399 3341511
Dry mouth 69.73 23.60 39 5910 9783 3370127
Flatulence 69.36 23.60 33 5916 5926 3373984
Premature baby 68.99 23.60 35 5914 7218 3372692
Pseudomembranous colitis 68.96 23.60 20 5929 886 3379024
Decreased appetite 67.87 23.60 68 5881 41422 3338488
Tachycardia 67.73 23.60 53 5896 23318 3356592
Acute hepatic failure 67.58 23.60 29 5920 4094 3375816
Carcinoid tumour of the stomach 67.11 23.60 12 5937 51 3379859
Myalgia 66.61 23.60 60 5889 32015 3347895
Nikolsky's sign 63.83 23.60 14 5935 193 3379717
Colitis microscopic 62.21 23.60 18 5931 791 3379119
Hepatitis acute 62.14 23.60 23 5926 2205 3377705
Septic shock 61.94 23.60 39 5910 12145 3367765
Oedema peripheral 61.18 23.60 59 5890 34302 3345608
Foetal exposure during pregnancy 60.21 23.60 42 5907 15509 3364401
Blister 60.15 23.60 34 5915 8700 3371210
Blood bilirubin increased 59.42 23.60 36 5913 10473 3369437
Syncope 59.31 23.60 51 5898 25582 3354328
Blood pressure increased 59.25 23.60 48 5901 22182 3357728
Vertigo 58.55 23.60 37 5912 11595 3368315
Abdominal discomfort 57.26 23.60 44 5905 18840 3361070
Delirium 57.07 23.60 34 5915 9594 3370316
Hyperbilirubinaemia 56.90 23.60 24 5925 3247 3376663
Sopor 56.88 23.60 25 5924 3739 3376171
Skin test positive 56.56 23.60 14 5935 335 3379575
Sepsis 56.52 23.60 55 5894 32318 3347592
Heart rate increased 55.79 23.60 39 5910 14447 3365463
Dermatitis bullous 55.45 23.60 21 5928 2145 3377765
Dehydration 54.73 23.60 55 5894 33594 3346316
Pancreatitis acute 54.14 23.60 29 5920 6679 3373231
Hepatic steatosis 53.47 23.60 26 5923 4894 3375016
Orthostatic hypotension 52.90 23.60 26 5923 5010 3374900
Back pain 52.64 23.60 57 5892 37948 3341962
Chronic kidney disease 52.62 23.60 28 5921 6364 3373546
Musculoskeletal stiffness 52.43 23.60 37 5912 13913 3365997
Seizure 51.47 23.60 58 5891 40342 3339568
Constipation 51.28 23.60 51 5898 30761 3349149
Neonatal respiratory distress syndrome 51.23 23.60 18 5931 1486 3378424
Prurigo 51.19 23.60 13 5936 346 3379564
Coma 51.17 23.60 35 5914 12517 3367393
International normalised ratio increased 50.88 23.60 37 5912 14578 3365332
Medication error 50.53 23.60 34 5915 11837 3368073
Vitamin B12 deficiency 50.20 23.60 15 5934 738 3379172
Haemolysis 49.41 23.60 19 5930 2023 3377887
Gastrointestinal disorder 49.18 23.60 32 5917 10537 3369373
Melaena 49.09 23.60 28 5921 7284 3372626
Bradycardia 48.70 23.60 38 5911 16631 3363279
Palpitations 48.31 23.60 40 5909 19043 3360867
Hyperparathyroidism 48.29 23.60 14 5935 619 3379291
Vitamin D deficiency 48.25 23.60 18 5931 1763 3378147
Rectal haemorrhage 47.67 23.60 30 5919 9328 3370582
Selective eating disorder 47.59 23.60 15 5934 883 3379027
Chest discomfort 47.48 23.60 38 5911 17247 3362663
Hypergastrinaemia 47.42 23.60 8 5941 22 3379888
Cerebellar syndrome 46.82 23.60 15 5934 931 3378979
Hallucination, auditory 44.93 23.60 21 5928 3620 3376290
Muscular weakness 44.08 23.60 39 5910 20302 3359608
Foetal growth restriction 43.83 23.60 17 5932 1852 3378058
Therapy non-responder 43.72 23.60 30 5919 10779 3369131
Contusion 43.37 23.60 34 5915 14976 3364934
Dysphagia 43.22 23.60 38 5911 19613 3360297
Jaundice cholestatic 42.65 23.60 15 5934 1241 3378669
Eczema 42.43 23.60 21 5928 4105 3375805
Pulseless electrical activity 42.26 23.60 16 5933 1632 3378278
Depression 42.19 23.60 52 5897 39718 3340192
Aortic dissection 41.80 23.60 13 5936 732 3379178
Blood creatinine increased 41.73 23.60 39 5910 21779 3358131
Medication residue present 41.20 23.60 17 5932 2176 3377734
Occupational exposure to air contaminants 41.06 23.60 6 5943 3 3379907
Vitamin B12 decreased 40.84 23.60 11 5938 370 3379540
Dermatitis exfoliative 40.73 23.60 18 5931 2725 3377185
Intentional self-injury 40.68 23.60 22 5927 5163 3374747
Abnormal palmar/plantar creases 40.66 23.60 8 5941 62 3379848
Loss of personal independence in daily activities 40.34 23.60 22 5927 5248 3374662
Circulatory collapse 40.17 23.60 23 5926 6026 3373884
Dysgeusia 39.93 23.60 29 5920 11395 3368515
Polyneuropathy 39.84 23.60 17 5932 2365 3377545
Sinoatrial block 39.53 23.60 10 5939 262 3379648
Amnesia 39.26 23.60 28 5921 10698 3369212
Burning sensation 39.09 23.60 26 5923 8878 3371032
Gait disturbance 38.76 23.60 42 5907 27950 3351960
Pernicious anaemia 38.68 23.60 9 5940 164 3379746
Enterochromaffin cell hyperplasia 38.41 23.60 6 5943 8 3379902
Gastritis 38.38 23.60 23 5926 6554 3373356
Hepatitis toxic 38.12 23.60 13 5936 981 3378929
Hallucination, visual 37.95 23.60 20 5929 4456 3375454
Intentional product misuse 37.19 23.60 29 5920 12672 3367238
Gastroenteritis clostridial 37.05 23.60 8 5941 102 3379808
Fixed eruption 36.99 23.60 9 5940 200 3379710
Coeliac disease 36.84 23.60 13 5936 1086 3378824
Hepatotoxicity 36.64 23.60 21 5928 5510 3374400
Generalised tonic-clonic seizure 36.55 23.60 24 5925 8018 3371892
Anaphylactic reaction 36.49 23.60 29 5920 13025 3366885
Pseudomonas infection 36.45 23.60 15 5934 1906 3378004
Immune thrombocytopenic purpura 36.39 23.60 16 5933 2393 3377517
Rash pruritic 36.04 23.60 25 5924 9139 3370771
Anxiety 36.03 23.60 48 5901 39581 3340329
Exposure during pregnancy 35.81 23.60 40 5909 27523 3352387
Chvostek's sign 35.70 23.60 6 5943 16 3379894
Off label use 35.39 23.60 56 5893 53921 3325989
Lip erosion 35.35 23.60 9 5940 242 3379668
Pancoast's syndrome 35.33 23.60 5 5944 1 3379909
Insomnia 34.99 23.60 45 5904 35853 3344057
Hepatic failure 34.88 23.60 26 5923 10626 3369284
Paranoia 34.88 23.60 18 5931 3841 3376069
Drug level increased 34.86 23.60 19 5930 4526 3375384
Epilepsy 34.70 23.60 22 5927 6923 3372987
Gastrointestinal haemorrhage 34.49 23.60 37 5912 24337 3355573
Blood creatine phosphokinase increased 34.44 23.60 28 5921 12985 3366925
Swelling 34.42 23.60 33 5916 19011 3360899
Hypoglycaemia 34.14 23.60 29 5920 14289 3365621
Lip oedema 33.76 23.60 12 5937 1024 3378886
Liver disorder 33.58 23.60 25 5924 10198 3369712
Pain in extremity 33.57 23.60 52 5897 49160 3330750
Restlessness 33.32 23.60 22 5927 7416 3372494
Depressed level of consciousness 33.18 23.60 26 5923 11439 3368471
Eructation 33.17 23.60 13 5936 1456 3378454
Hypotonia neonatal 33.15 23.60 10 5939 508 3379402
Depressed mood 33.09 23.60 21 5928 6620 3373290
Cardiac failure 32.91 23.60 33 5916 20072 3359838
Torsade de pointes 32.89 23.60 16 5933 3013 3376897
Cough 32.79 23.60 46 5903 39812 3340098
Drug intolerance 32.52 23.60 26 5923 11772 3368138
Iron deficiency anaemia 32.23 23.60 15 5934 2560 3377350
Neuroendocrine tumour 32.13 23.60 8 5941 196 3379714
Death 32.12 23.60 100 5849 152224 3227686
Myoclonus 31.92 23.60 17 5932 3866 3376044
Mixed liver injury 31.89 23.60 9 5940 361 3379549
Unresponsive to stimuli 31.85 23.60 22 5927 7986 3371924
Glaucoma 31.79 23.60 15 5934 2641 3377269
Colitis 31.75 23.60 21 5928 7100 3372810
Urinary tract infection 31.67 23.60 40 5909 31288 3348622
Joint swelling 31.67 23.60 30 5919 17027 3362883
Hyperbilirubinaemia neonatal 31.22 23.60 8 5941 221 3379689
Cardiac arrest 31.04 23.60 37 5912 27282 3352628
Escherichia urinary tract infection 30.95 23.60 12 5937 1305 3378605
C-reactive protein increased 30.94 23.60 23 5926 9360 3370550
Wound treatment 30.60 23.60 7 5942 118 3379792
Diarrhoea haemorrhagic 30.40 23.60 13 5936 1818 3378092
Cerebellar ischaemia 29.79 23.60 6 5943 53 3379857
Therapeutic product cross-reactivity 29.65 23.60 8 5941 271 3379639
Intervertebral discitis 29.37 23.60 9 5940 482 3379428
Personality disorder 29.32 23.60 9 5940 485 3379425
Allergy test positive 29.12 23.60 6 5943 60 3379850
Respiratory failure 29.06 23.60 33 5916 23108 3356802
Dysmorphism 29.01 23.60 10 5939 779 3379131
Type I hypersensitivity 28.71 23.60 9 5940 520 3379390
Osteoporosis 28.68 23.60 17 5932 4748 3375162
Discomfort 28.48 23.60 19 5930 6517 3373393
Photosensitivity reaction 28.45 23.60 15 5934 3342 3376568
Nocturia 28.45 23.60 12 5937 1622 3378288
Skin hyperpigmentation 28.31 23.60 11 5938 1203 3378707
Glossodynia 28.31 23.60 13 5936 2151 3377759
Urinary retention 28.24 23.60 20 5929 7552 3372358
Blood magnesium decreased 28.24 23.60 12 5937 1652 3378258
Drug prescribing error 27.89 23.60 16 5933 4204 3375706
Myopathy 27.77 23.60 14 5935 2845 3377065
Diabetes mellitus 27.75 23.60 24 5925 12109 3367801
Aphasia 27.64 23.60 19 5930 6842 3373068
Purpura 27.40 23.60 14 5935 2926 3376984
Electrocardiogram QRS complex prolonged 27.21 23.60 11 5938 1335 3378575
Febrile neutropenia 27.18 23.60 29 5920 18946 3360964
Bradyphrenia 26.92 23.60 11 5938 1373 3378537
Leukaemoid reaction 26.70 23.60 6 5943 93 3379817
Lethargy 26.68 23.60 25 5924 13990 3365920
Visual impairment 26.48 23.60 25 5924 14121 3365789
Agitation 26.28 23.60 29 5920 19677 3360233
Clostridial infection 26.28 23.60 11 5938 1459 3378451
Immunosuppression 26.13 23.60 11 5938 1479 3378431
Cutaneous lupus erythematosus 26.03 23.60 9 5940 708 3379202
Hypoaesthesia oral 25.88 23.60 13 5936 2620 3377290
Tongue oedema 25.56 23.60 10 5939 1114 3378796
Haematuria 25.46 23.60 21 5928 9931 3369979
Pallor 25.46 23.60 17 5932 5838 3374072
Asthma 25.31 23.60 23 5926 12379 3367531
Chills 25.30 23.60 30 5919 21992 3357918
Klebsiella infection 25.29 23.60 10 5939 1146 3378764
Haematemesis 25.25 23.60 18 5931 6867 3373043
Myocardial infarction 25.15 23.60 43 5906 44090 3335820
Infection 24.98 23.60 32 5917 25370 3354540
Malnutrition 24.97 23.60 13 5936 2823 3377087
Skin exfoliation 24.94 23.60 19 5930 8018 3371892
Pneumonia 24.93 23.60 56 5893 70087 3309823
Maternal exposure during pregnancy 24.88 23.60 21 5928 10250 3369660
Listeria encephalitis 24.74 23.60 5 5944 45 3379865
Renal tubular disorder 24.70 23.60 10 5939 1219 3378691
Thrombosis 24.67 23.60 24 5925 14066 3365844
Arrhythmia 24.66 23.60 21 5928 10376 3369534
Mucosal erosion 24.63 23.60 7 5942 288 3379622
Hiatus hernia 24.39 23.60 13 5936 2961 3376949
Acute psychosis 24.27 23.60 9 5940 866 3379044
Lymphopenia 24.26 23.60 14 5935 3719 3376191
Nonspecific reaction 24.11 23.60 8 5941 555 3379355
Inflammation 23.90 23.60 18 5931 7467 3372443
Treatment failure 23.79 23.60 17 5932 6507 3373403
Rash generalised 23.70 23.60 20 5929 9762 3370148
Cerebrovascular accident 23.65 23.60 37 5912 35251 3344659

Pharmacologic Action:

SourceCodeDescription
ATC A02BC02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors
ATC A02BD04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
ATC A02BD11 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Combinations for eradication of Helicobacter pylori
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054328 Proton Pump Inhibitors
CHEBI has role CHEBI:49201 anti-ulcer drug
FDA EPC N0000175525 Proton Pump Inhibitor

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Multiple endocrine adenomas indication 60549007
Gastroesophageal reflux disease indication 235595009 DOID:8534
Maintenance of Healing Erosive Esophagitis indication
Gastric Hypersecretory Conditions indication
Upper gastrointestinal hemorrhage off-label use 37372002
Duodenal ulcer disease off-label use 51868009 DOID:1724
Gastric ulcer off-label use 397825006 DOID:10808
Pathological Gastric Hypersecretory Condition off-label use
Duodenal Ulcer due to H. Pylori off-label use
Prevention of NSAID-Induced Gastric Ulcer off-label use
Osteoporosis contraindication 64859006 DOID:11476
Pernicious anemia contraindication 84027009 DOID:13381
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.42 acidic
pKa2 3.58 Basic
pKa3 2.32 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 40MG BASE PROTONIX WYETH PHARMS INC N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7550153 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD
EQ 40MG BASE PROTONIX WYETH PHARMS INC N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7553498 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD
EQ 40MG BASE PROTONIX WYETH PHARMS INC N022020 Nov. 14, 2007 RX FOR SUSPENSION, DELAYED RELEASE ORAL 7838027 Sept. 30, 2024 EROSIVE ESOPHAGITIS, HYPERSECRETORY CONDITIONS INCLUDING ZOLLINGER-ELLISON SYNDROME, MAINTENANCE OF HEALING OF EROSIVE ESOPHAGITIS AND REDUCTION OF SYMPTOMS IN PATIENTS WITH GERD

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR CHEMBL CHEMBL
Solute carrier family 22 member 2 Transporter IC50 5.82 CHEMBL
Multidrug and toxin extrusion protein 2 Transporter IC50 4.36 CHEMBL
Multidrug and toxin extrusion protein 1 Transporter IC50 5.55 CHEMBL
Sodium/potassium-transporting ATPase subunit alpha-1 Transporter WOMBAT-PK
Fatty acid synthase Enzyme Ki 5.39 CHEMBL
Indoleamine 2,3-dioxygenase 2 Enzyme IC50 4.90 CHEMBL
Potassium-transporting ATPase Enzyme IC50 6 SCIENTIFIC LITERATURE

External reference:

IDSource
DB00213 DRUGBANK_ID
4021208 VUID
N0000148654 NUI
C0081876 UMLSCUI
7260 IUPHAR_LIGAND_ID
D02593 KEGG_DRUG
6871619Q5X UNII
164579-32-2 SECONDARY_CAS_RN
4021208 VANDF
130104 MMSL
N0000007399 NDFRT
N0000148654 NDFRT
006006 NDDF
d04514 MMSL
40790 RXNORM
317317009 SNOMEDCT_US
395821003 SNOMEDCT_US
CHEMBL1502 ChEMBL_ID
4679 PUBCHEM_CID
CHEMBL1200408 ChEMBL_ID
C064276 MESH_SUPPLEMENTAL_RECORD_UI
6548 INN_ID
CHEBI:7915 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-0841 TABLET, DELAYED RELEASE 40 mg ORAL NDA 20 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-0843 TABLET, DELAYED RELEASE 20 mg ORAL NDA 20 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-0844 GRANULE, DELAYED RELEASE 40 mg ORAL NDA 20 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-0923 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 18 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-0941 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 18 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-2001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 18 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 0008-4001 INJECTION, POWDER, FOR SOLUTION 40 mg INTRAVENOUS NDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0011 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-0012 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9284 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 17 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9300 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 40 mg INTRAVENOUS NDA 17 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6688 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0378-6689 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7629 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 17 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7916 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0615-7998 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0904-6474 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 18 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 13668-429 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 18 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 16590-635 TABLET, DELAYED RELEASE 20 mg ORAL NDA 18 sections
PROTONIX HUMAN PRESCRIPTION DRUG LABEL 1 16590-939 TABLET, DELAYED RELEASE 20 mg ORAL NDA 19 sections
Protonix HUMAN PRESCRIPTION DRUG LABEL 1 21695-108 TABLET, DELAYED RELEASE 40 mg ORAL NDA 17 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 21695-771 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 17 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 31722-712 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 19 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 31722-713 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 19 sections
Pantoprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 33342-019 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 19 sections
Pantoprazole sodium HUMAN PRESCRIPTION DRUG LABEL 1 33342-020 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 19 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 33358-536 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 17 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 35356-622 TABLET, DELAYED RELEASE 40 mg ORAL ANDA 17 sections
PANTOPRAZOLE SODIUM HUMAN PRESCRIPTION DRUG LABEL 1 35356-768 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 17 sections
Pantoprazole Sodium HUMAN PRESCRIPTION DRUG LABEL 1 42043-370 TABLET, DELAYED RELEASE 20 mg ORAL ANDA 18 sections