dexrabeprazole indications/contra

Stem definitionDrug idCAS RN
antiulcer, benzimidazole derivatives 4867 177795-60-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • E3810
  • dexrabeprazole
  • dexrabeprazole sodium
  • dexpure
  • Molecular weight: 359.44
  • Formula: C18H21N3O3S
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 77.10
  • ALOGS: -3.03
  • ROTB: 8

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A02BC07 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Proton pump inhibitors

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Peptic ulcer indication 13200003 DOID:750
Erosive esophagitis indication 40719004
Duodenal ulcer disease indication 51868009 DOID:1724
Zollinger-Ellison syndrome indication 53132006 DOID:0050782
Peptic reflux disease indication 57643001 DOID:13976
Gastroesophageal reflux disease indication 235595009 DOID:8534
Gastric ulcer indication 397825006 DOID:10808
Duodenal Ulcer due to H. Pylori indication
Pathological Gastric Hypersecretory Condition indication
Maintenance of Healing Erosive Esophagitis indication
Gastric Hypersecretory Conditions indication
Chronic heart failure contraindication 48447003
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Osteoporosis contraindication 64859006 DOID:11476
Oliguria contraindication 83128009
Atrophic gastritis contraindication 84568007 DOID:8929
Fracture of bone contraindication 125605004
Hypomagnesemia contraindication 190855004
Disease of liver contraindication 235856003 DOID:409
Edema contraindication 267038008
Upper gastrointestinal hemorrhage off-label use 37372002

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.23 acidic
pKa2 3.9 Basic
pKa3 2.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium-transporting ATPase Transporter INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
CHEBI:134729 CHEBI
CHEMBL1615209 ChEMBL_ID
5029 PUBCHEM_CID
RZX PDB_CHEM_ID

Pharmaceutical products:

None