amrubicin indications/contra

Stem definitionDrug idCAS RN
antineoplastics, daunorubicin derivatives 202 110267-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amrubicin hydrochloride
  • amrubicin HCl
  • amrubicin
; a 9-amino-anthracycline antibiotic
  • Molecular weight: 483.47
  • Formula: C25H25NO9
  • CLOGP: 0.03
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 176.61
  • ALOGS: -2.63
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Disease recurrence 189.21 74.86 29 54 5205 3380571

Pharmacologic Action:

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SourceCodeDescription
ATC L01DB10 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
Anthracyclines and related substances
MeSH PA D000970 Antineoplastic Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.12 acidic
pKa2 9.39 acidic
pKa3 10.45 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D08854 KEGG_DRUG
93N13LB4Z2 UNII
6802 INN_ID
3035016 PUBCHEM_CID
CHEMBL481958 ChEMBL_ID
CHEMBL1186894 ChEMBL_ID
DB06263 DRUGBANK_ID
110311-30-3 SECONDARY_CAS_RN
C055866 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135779 CHEBI

Pharmaceutical products:

None